Objective:In traditional medicine,Asari Radix et Rhizoma(Xi Xin)is used to effectively treat respiratory diseases.However,the therapeutic portion of Xi Xin contains trace quantities of aristolochic acid I(AAI),which r...Objective:In traditional medicine,Asari Radix et Rhizoma(Xi Xin)is used to effectively treat respiratory diseases.However,the therapeutic portion of Xi Xin contains trace quantities of aristolochic acid I(AAI),which raises safety concerns.Furthermore,no compelling laboratory evidence confirms its safety.AAI-induced extensive renal tubular necrosis and inflammatory cell infiltration occurred primarily in the cortex and outer medulla.Accordingly,we examined the changes in metabolites within the aforementioned areas and thoroughly investigated the interactions between these differential metabolites and immune cells.Methods:We mapped the spatial distribution of the differential metabolites L-glutamic acid and glutamine in mouse kidneys and explored the underlying mechanisms using transcriptomics and flow cytometry,further validating these findings through co-culture experiments in vitro.Results:Administering 1 mg/kg AAI daily for 7 days(approximately 200 times the pharmacopeial Xi Xin dose)did not induce detectable levels of carcinogenic 7-(deoxyadenosin-N6-yl)-aristolactam I(dA-ALI)in mouse kidneys.However,dA-ALI was detected on the day after the administration of 10 mg/kg AAI.Mice with lipopolysaccharide-induced pneumonia exhibit increased tolerance to AAI-mediated nephrotoxicity.Based on integrated spatial metabolomics and renal transcriptomic analyses,increased tolerance to AAI-mediated nephrotoxicity may be related to glutamine-mediated oxidative stress regulation mechanisms.During pneumonia,mouse kidneys exhibit both immune and metabolic stress responses.Ly6C^(+)macrophages convert L-glutamic acid into glutamine,thereby reducing reactive oxygen species(ROS)levels in the extracellular matrix.This process,which is regulated by the ITGA5 receptor in renal tubular epithelial cells,modulates the pAkt/pNrf2/NQO1 pathway and reduces AAI-induced kidney damage.Conclusions:Collectively,our findings indicate that Xi Xin is safe at conventional clinical dosages,and its targeted use can further minimize potential risks.展开更多
Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different educ...Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different education stages is still limited.A new framework was established to evaluate the spatial heterogeneity and its influencing factors across all education stages(kindergarten,primary school,middle school,college)in 1100 schools at the urban scale of Xi’an,China.The research results show that:1)CGS is lower in the Baqiao district and higher in the Yanta and Xincheng districts of Xi’an City.‘Green wealthy schools are mainly concentrated in the Weiyang,Chang’an and Yanta districts.2)CGS of these schools in descending order is college(31.40%)>kindergarten(18.32%)>middle school(13.56%)>primary school(10.70%).3)Colleges have the most recreation sites(n(number)=2),the best education levels(11.93 yr),and the lowest housing prices(1.18×10^(4) yuan(RMB)/m^(2));middle schools have the highest public expenditures(3.97×10^(9) yuan/yr);primary schools have the highest CGS accessibility(travel time gap(TTG)=31.33).4)Multiscale Geographically Weighted Regression model and Spearman’s test prove that recreation sites have a significant positive impact on college green spaces(0.28–0.35),and education level has a significant positive impact on kindergarten green spaces(0.16–0.24).This research framework provides important insights for the assessment of school greening initiatives aimed at fostering healthier learning environments for future generations.展开更多
On February 17,2025,when China braves the economic headwinds and emerges from multiple challenges with hard-won feats,Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,also Chinese pre...On February 17,2025,when China braves the economic headwinds and emerges from multiple challenges with hard-won feats,Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,also Chinese president and chairman of the Central Military Commission,attended a symposium on private enterprises in Beijing and delivered an important speech.He stressed that on the new journey of the new era,the private economy has broad development prospects and immense potential,and it is the perfect time for private companies and entrepreneurs to fully demonstrate their prowess.展开更多
Chinese President Xi Jinping met with Singaporean Prime Minister Lawrence Wong in Beijing on June 24.Xi Jinping congratulated Wong on his second term in office.Noting that this year marks the 35th anniversary of diplo...Chinese President Xi Jinping met with Singaporean Prime Minister Lawrence Wong in Beijing on June 24.Xi Jinping congratulated Wong on his second term in office.Noting that this year marks the 35th anniversary of diplomatic relations between China and Singapore,Xi Jinping highlighted that the two sides have consistently upheld mutual understanding and respect,which has provided a solid foundation for the stable and healthy development of bilateral relations.Cooperation between the two countries has aligned with China’s development priorities at various stages,yielding substantial outcomes such as the Suzhou Industrial Park,significantly contributing to each country’s modernization efforts,and also setting a benchmark for cooperation among regional nations,Xi Jinping noted.展开更多
FOR many people in Sweden and across the West,China’s political system and leadership remain distant,often mediated through headlines about trade disputes,human rights controversies,or great power rivalry.What is les...FOR many people in Sweden and across the West,China’s political system and leadership remain distant,often mediated through headlines about trade disputes,human rights controversies,or great power rivalry.What is less familiar are the internal logics,historical references,and developmental ambitions that shape the self-understanding of Chinese leaders and their vision for the country’s role in the world.展开更多
The governance of state-owned enterprises(SOEs)has long been central to political and institutional economic debates.Critics often associate SOEs with ine"ciency,rent-seeking and dogma,treating them as relics of ...The governance of state-owned enterprises(SOEs)has long been central to political and institutional economic debates.Critics often associate SOEs with ine"ciency,rent-seeking and dogma,treating them as relics of command economies.Yet in many developmental states,they have been engines of industrialisation,technological progress and national resilience.China provides perhaps the most striking example.Its SOEs have survived and evolved,some becoming globally competitive multinationals in energy,infrastructure and telecommunications.展开更多
President Xi Jinping’s second state visit to Cambodia in nine years is an important milestone in the development of bilateral relations and practical cooperation,which will endow new meaning to the China-Cambodia com...President Xi Jinping’s second state visit to Cambodia in nine years is an important milestone in the development of bilateral relations and practical cooperation,which will endow new meaning to the China-Cambodia community with a shared future.Strategic Guidance with Political Mutual Trust A high level of political mutual trust has paved the way for the development of China-Cambodia relations.展开更多
China celebrates its annual Youth Day on 4 May,honouring the legacy of the patriotic May Fourth Movement of 1919 that shaped modern Chinese history.On this occasion,Chinese President Xi Jinping extended festive greeti...China celebrates its annual Youth Day on 4 May,honouring the legacy of the patriotic May Fourth Movement of 1919 that shaped modern Chinese history.On this occasion,Chinese President Xi Jinping extended festive greetings to young people across the country and expressed high expectations for their contributions.展开更多
The urban fringe areas,situated between the urban-rural interface and critical ecological conservation zones,represent highly sensitive and rapidly evolving transitional zones within urban ecosystems,which are signifi...The urban fringe areas,situated between the urban-rural interface and critical ecological conservation zones,represent highly sensitive and rapidly evolving transitional zones within urban ecosystems,which are significantly impacted by the pressures of urban ex-pansion.However,current academic research on their spatial identification and ecological risks remains notably limited.This study fo-cused on Xi’an of China,utilizing multi-source data and the K-means algorithm to identify urban fringe areas during 2014-2022.Addi-tionally,this study assessed the landscape ecological risks from three perspectives,human activities,landscape fragmentation and ecolo-gical restoration in 2022.The results demonstrate that:1)Xi’an’s urban core and urban fringe areas significantly expanded between 2014 and 2022,growing from 145 to 471 km^(2) and 1319 to 1884 km^(2),respectively.The near urban core and mid-zone areas increased,while the near rural area initially decreased and then slightly recovered.2)Over half of the urban fringe area is at medium to high ecolo-gical risk,with higher risk zones concentrated near the urban core,and slight risk areas primarily along the Weihe River and northern edges.3)Landscape fragmentation and road network effects have become primary drivers in urban fringe areas,prompting a shift in their role from‘future expansion area’to‘ecological reserve area’to better support sustainable urban development.This study high-lights the spatial complexity and ecological significance of urban fringe areas,emphasizing their critical role in urban ecological man-agement.展开更多
With socialism with Chinese characteristics entering into a new era,the great rejuvenation of the Chinese nation is now on an irreversible course.China has come ever closer to the center stage of the world.Grasping th...With socialism with Chinese characteristics entering into a new era,the great rejuvenation of the Chinese nation is now on an irreversible course.China has come ever closer to the center stage of the world.Grasping the international landscape,the pulse of the times,the trends of the world,and with the progress of human development in mind,General Secretary Xi Jinping has put forward a series of original diplomatic concepts and major initiatives,creating the Xi Jinping Thought on Diplomacy.展开更多
The complexity of idioms poses challenges to online translation.From the perspective of online translation,this study conducts an in-depth exploration of idiom translation strategies by taking Xi Jinping:The Governanc...The complexity of idioms poses challenges to online translation.From the perspective of online translation,this study conducts an in-depth exploration of idiom translation strategies by taking Xi Jinping:The Governance of China(Volume IV)as the research object and extracts 649 idioms from this work,conducting 1,947 translation queries on three major platforms.It helps to reveal the strategic differences and effectiveness of online translation in handling idioms and emphasizes the importance of cultural adaptability in translation practice,which provides theoretical support and practical guidance for optimizing online translation technology and improving the quality of idiom translation into English.展开更多
Xi Jinping Thought on Ecological Civilization contains new concepts,ideas,and strategies that feature Chinese characteristics and the spirit of the times and promote the progress of human civilization.Xi Jinping Thoug...Xi Jinping Thought on Ecological Civilization contains new concepts,ideas,and strategies that feature Chinese characteristics and the spirit of the times and promote the progress of human civilization.Xi Jinping Thought on Ecological Civilization is also the fundamental guide for compliance and action in terms of China’s practices in building an ecological civilization in the new era.Since the 18th National Congress of the Communist Party of China(CPC),Xi Jinping,general secretary of the Communist Party of China Central Committee,has made several inspection tours to Sichuan and given a series of important instructions on green development and building an ecological civilization in Sichuan province.This paper reviews the contemporary meaning and theoretical significance of Xi Jinping Thought on Ecological Civilization and uses them to systematically examine the overall performance of building a beautiful Sichuan,following the guidance of Xi Jinping’s important instructions for the governance of Sichuan.This paper selects and analyzes typical cases that demonstrate the national effect in Sichuan to summarize Sichuan’s unique experiences in the practice of Xi Jinping Thought on Ecological Civilization.展开更多
Ancient poetry is an irreplaceable component of Chinese culture and an invaluable asset in China’s cultural heritage.With the rapid development of globalization and informatization,Chinese poem is attracting more and...Ancient poetry is an irreplaceable component of Chinese culture and an invaluable asset in China’s cultural heritage.With the rapid development of globalization and informatization,Chinese poem is attracting more and more interests and focuses as one part of China’s cultural soft power which plays an important role on spreading traditional Chinese culture.Systemic functional linguistics mainly explores the essence,entailment,system and structure of language from the perspective of social culture,especially the relationship between context and discourse.Therefore,the paper applies the register theory to Chinese poem translations of Xu Yuanchong and Yang Xianyi of“Chun Ye Xi Yu”in order to compare two translated texts from three aspects of field,tenor,and mode,and examine the expression of the connotation of the original poem between the two translations.展开更多
基金supported by the Consulting Project Funds of the Chinese Academy of Engineering(2023-XZ-88,China)Key Program of the National Natural Science Foundation of China(81721002 and 82230118,China)Key Program of the National Natural Science Foundation of China Regional Union Fund(U23A20519,China).
文摘Objective:In traditional medicine,Asari Radix et Rhizoma(Xi Xin)is used to effectively treat respiratory diseases.However,the therapeutic portion of Xi Xin contains trace quantities of aristolochic acid I(AAI),which raises safety concerns.Furthermore,no compelling laboratory evidence confirms its safety.AAI-induced extensive renal tubular necrosis and inflammatory cell infiltration occurred primarily in the cortex and outer medulla.Accordingly,we examined the changes in metabolites within the aforementioned areas and thoroughly investigated the interactions between these differential metabolites and immune cells.Methods:We mapped the spatial distribution of the differential metabolites L-glutamic acid and glutamine in mouse kidneys and explored the underlying mechanisms using transcriptomics and flow cytometry,further validating these findings through co-culture experiments in vitro.Results:Administering 1 mg/kg AAI daily for 7 days(approximately 200 times the pharmacopeial Xi Xin dose)did not induce detectable levels of carcinogenic 7-(deoxyadenosin-N6-yl)-aristolactam I(dA-ALI)in mouse kidneys.However,dA-ALI was detected on the day after the administration of 10 mg/kg AAI.Mice with lipopolysaccharide-induced pneumonia exhibit increased tolerance to AAI-mediated nephrotoxicity.Based on integrated spatial metabolomics and renal transcriptomic analyses,increased tolerance to AAI-mediated nephrotoxicity may be related to glutamine-mediated oxidative stress regulation mechanisms.During pneumonia,mouse kidneys exhibit both immune and metabolic stress responses.Ly6C^(+)macrophages convert L-glutamic acid into glutamine,thereby reducing reactive oxygen species(ROS)levels in the extracellular matrix.This process,which is regulated by the ITGA5 receptor in renal tubular epithelial cells,modulates the pAkt/pNrf2/NQO1 pathway and reduces AAI-induced kidney damage.Conclusions:Collectively,our findings indicate that Xi Xin is safe at conventional clinical dosages,and its targeted use can further minimize potential risks.
基金Under the auspices of Natural Science Basic Research Plan in Shaanxi Province of China(No.2024JC-YBMS-196)。
文摘Increased exposure to campus green spaces can make a positive contribution to the healthy development of students.However,understanding of the current supply of campus green space(CGS)and its drivers at different education stages is still limited.A new framework was established to evaluate the spatial heterogeneity and its influencing factors across all education stages(kindergarten,primary school,middle school,college)in 1100 schools at the urban scale of Xi’an,China.The research results show that:1)CGS is lower in the Baqiao district and higher in the Yanta and Xincheng districts of Xi’an City.‘Green wealthy schools are mainly concentrated in the Weiyang,Chang’an and Yanta districts.2)CGS of these schools in descending order is college(31.40%)>kindergarten(18.32%)>middle school(13.56%)>primary school(10.70%).3)Colleges have the most recreation sites(n(number)=2),the best education levels(11.93 yr),and the lowest housing prices(1.18×10^(4) yuan(RMB)/m^(2));middle schools have the highest public expenditures(3.97×10^(9) yuan/yr);primary schools have the highest CGS accessibility(travel time gap(TTG)=31.33).4)Multiscale Geographically Weighted Regression model and Spearman’s test prove that recreation sites have a significant positive impact on college green spaces(0.28–0.35),and education level has a significant positive impact on kindergarten green spaces(0.16–0.24).This research framework provides important insights for the assessment of school greening initiatives aimed at fostering healthier learning environments for future generations.
文摘On February 17,2025,when China braves the economic headwinds and emerges from multiple challenges with hard-won feats,Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,also Chinese president and chairman of the Central Military Commission,attended a symposium on private enterprises in Beijing and delivered an important speech.He stressed that on the new journey of the new era,the private economy has broad development prospects and immense potential,and it is the perfect time for private companies and entrepreneurs to fully demonstrate their prowess.
文摘Chinese President Xi Jinping met with Singaporean Prime Minister Lawrence Wong in Beijing on June 24.Xi Jinping congratulated Wong on his second term in office.Noting that this year marks the 35th anniversary of diplomatic relations between China and Singapore,Xi Jinping highlighted that the two sides have consistently upheld mutual understanding and respect,which has provided a solid foundation for the stable and healthy development of bilateral relations.Cooperation between the two countries has aligned with China’s development priorities at various stages,yielding substantial outcomes such as the Suzhou Industrial Park,significantly contributing to each country’s modernization efforts,and also setting a benchmark for cooperation among regional nations,Xi Jinping noted.
文摘FOR many people in Sweden and across the West,China’s political system and leadership remain distant,often mediated through headlines about trade disputes,human rights controversies,or great power rivalry.What is less familiar are the internal logics,historical references,and developmental ambitions that shape the self-understanding of Chinese leaders and their vision for the country’s role in the world.
文摘The governance of state-owned enterprises(SOEs)has long been central to political and institutional economic debates.Critics often associate SOEs with ine"ciency,rent-seeking and dogma,treating them as relics of command economies.Yet in many developmental states,they have been engines of industrialisation,technological progress and national resilience.China provides perhaps the most striking example.Its SOEs have survived and evolved,some becoming globally competitive multinationals in energy,infrastructure and telecommunications.
文摘President Xi Jinping’s second state visit to Cambodia in nine years is an important milestone in the development of bilateral relations and practical cooperation,which will endow new meaning to the China-Cambodia community with a shared future.Strategic Guidance with Political Mutual Trust A high level of political mutual trust has paved the way for the development of China-Cambodia relations.
文摘China celebrates its annual Youth Day on 4 May,honouring the legacy of the patriotic May Fourth Movement of 1919 that shaped modern Chinese history.On this occasion,Chinese President Xi Jinping extended festive greetings to young people across the country and expressed high expectations for their contributions.
基金Under the auspices of National Natural Science Foundation of China(No.42271214)National Key R&D Program of China(No.2022YFC3800700)+1 种基金Key Research Program of Gansu Province(No.23ZDKA0004)Key Program of Natural Science Foundation of Gansu Province(No.21JR7RA281,24JRRA250)。
文摘The urban fringe areas,situated between the urban-rural interface and critical ecological conservation zones,represent highly sensitive and rapidly evolving transitional zones within urban ecosystems,which are significantly impacted by the pressures of urban ex-pansion.However,current academic research on their spatial identification and ecological risks remains notably limited.This study fo-cused on Xi’an of China,utilizing multi-source data and the K-means algorithm to identify urban fringe areas during 2014-2022.Addi-tionally,this study assessed the landscape ecological risks from three perspectives,human activities,landscape fragmentation and ecolo-gical restoration in 2022.The results demonstrate that:1)Xi’an’s urban core and urban fringe areas significantly expanded between 2014 and 2022,growing from 145 to 471 km^(2) and 1319 to 1884 km^(2),respectively.The near urban core and mid-zone areas increased,while the near rural area initially decreased and then slightly recovered.2)Over half of the urban fringe area is at medium to high ecolo-gical risk,with higher risk zones concentrated near the urban core,and slight risk areas primarily along the Weihe River and northern edges.3)Landscape fragmentation and road network effects have become primary drivers in urban fringe areas,prompting a shift in their role from‘future expansion area’to‘ecological reserve area’to better support sustainable urban development.This study high-lights the spatial complexity and ecological significance of urban fringe areas,emphasizing their critical role in urban ecological man-agement.
文摘With socialism with Chinese characteristics entering into a new era,the great rejuvenation of the Chinese nation is now on an irreversible course.China has come ever closer to the center stage of the world.Grasping the international landscape,the pulse of the times,the trends of the world,and with the progress of human development in mind,General Secretary Xi Jinping has put forward a series of original diplomatic concepts and major initiatives,creating the Xi Jinping Thought on Diplomacy.
基金funded by Innovation Training Project for University Students of Nanjing University of Aeronautics and Astronautics in 2024:“Research on Strategies for English Translation of Idioms Based on Online Translation-A Case Study of Xi Jinping:The Governance of China(Volume Ⅳ)”(No.:2024CX012008).
文摘The complexity of idioms poses challenges to online translation.From the perspective of online translation,this study conducts an in-depth exploration of idiom translation strategies by taking Xi Jinping:The Governance of China(Volume IV)as the research object and extracts 649 idioms from this work,conducting 1,947 translation queries on three major platforms.It helps to reveal the strategic differences and effectiveness of online translation in handling idioms and emphasizes the importance of cultural adaptability in translation practice,which provides theoretical support and practical guidance for optimizing online translation technology and improving the quality of idiom translation into English.
文摘Xi Jinping Thought on Ecological Civilization contains new concepts,ideas,and strategies that feature Chinese characteristics and the spirit of the times and promote the progress of human civilization.Xi Jinping Thought on Ecological Civilization is also the fundamental guide for compliance and action in terms of China’s practices in building an ecological civilization in the new era.Since the 18th National Congress of the Communist Party of China(CPC),Xi Jinping,general secretary of the Communist Party of China Central Committee,has made several inspection tours to Sichuan and given a series of important instructions on green development and building an ecological civilization in Sichuan province.This paper reviews the contemporary meaning and theoretical significance of Xi Jinping Thought on Ecological Civilization and uses them to systematically examine the overall performance of building a beautiful Sichuan,following the guidance of Xi Jinping’s important instructions for the governance of Sichuan.This paper selects and analyzes typical cases that demonstrate the national effect in Sichuan to summarize Sichuan’s unique experiences in the practice of Xi Jinping Thought on Ecological Civilization.
文摘Ancient poetry is an irreplaceable component of Chinese culture and an invaluable asset in China’s cultural heritage.With the rapid development of globalization and informatization,Chinese poem is attracting more and more interests and focuses as one part of China’s cultural soft power which plays an important role on spreading traditional Chinese culture.Systemic functional linguistics mainly explores the essence,entailment,system and structure of language from the perspective of social culture,especially the relationship between context and discourse.Therefore,the paper applies the register theory to Chinese poem translations of Xu Yuanchong and Yang Xianyi of“Chun Ye Xi Yu”in order to compare two translated texts from three aspects of field,tenor,and mode,and examine the expression of the connotation of the original poem between the two translations.
