Objectives:Postmenopausal women with stress urinary incontinence(SUI)exhibit low androgen expression.This study aimed to evaluate the efficacy and safety of vaginal androgen combined with pelvic floor muscle training(...Objectives:Postmenopausal women with stress urinary incontinence(SUI)exhibit low androgen expression.This study aimed to evaluate the efficacy and safety of vaginal androgen combined with pelvic floor muscle training(PFMT)in the treatment of SUI in postmenopausal women.Methods:Postmenopausal women with SUI were recruited from Hainan West Central Hospital between January 2024 and March 2025.Participants were randomly assigned in a double-blind manner to receive either vaginal androgen cream combined with PFMT(treatment group)or a visually identical placebo cream(without androgens)combined with PFMT(control group).The vaginal cream was applied to the vaginal wall at a dose of 0.5 g per application,twice weekly for a total of 10 applications,while PFMT was conducted for 8 weeks.The clinical efficacy and safety were compared between the two groups.Results:A total of 61 patients were finally enrolled,with 31 in the treatment group and 30 in the control group.At both 3-month and 6-month follow-ups,the treatment group demonstrated significantly lower values in daily pad usage(p<0.05),24-h pad test scores(p<0.05),and ICIQ-UI SF scores(p<0.05)compared to the control group.The improvement rate of urinary incontinence was significantly higher in the treatment group(p<0.05).Compared to baseline,the treatment group showed statistically significant reductions in all three outcome measures(all p<0.05).No severe adverse events were reported in either group during the treatment period.Conclusions:Androgen therapy combined with PFMT significantly improved the urinary incontinence remission rate in postmenopausal women with SUI,with no severe adverse effects observed.These findings suggest that androgen therapy may represent a novel therapeutic approach for SUI management in postmenopausal women.展开更多
Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure f...Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure from the living environment.This study included 1311 women in late pregnancy from the Zunyi birth cohort and measured the urinary concentrations of 10 hydroxylated PAH metabolites(OH-PAHs).Risk assessment was conducted based on the estimated daily intake to calculate the hazard quotient and hazard index(HI).A linear regression model was used to analyze the relationship between creatinine-adjusted OH-PAHs concentrations and living environment and lifestyle factors,while principal component analysis was applied to trace the sources of PAHs exposure.1-OHPYR was detected in all participants’urine,with naphthalene metabolites having the highest concentrations among creatinine-adjusted PAHs.OH-PAHs concentrations were associated with housing type,room number,cooking frequency,household size,exercise frequency,fuel type,distance from main road,and drinking water source.Pregnant women using traditional fuels and living in bungalows had higher health risks than those using clean energy and living in buildings.Those living within 100 m of a main road had higher HI than those farther away.Coal combustion was identified as the primary source of PAHs exposure.The study emphasizes the importance of reducing PAHs exposure,especially for pregnant women living in polluted environments.It recommends public health interventions such as improving indoor ventilation and providing clean energy to reduce related health risks.展开更多
Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 ...Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 high-risk pregnancy patients treated in our hospital from January 2023 to January 2024 were selected as the study subjects.These patients were randomly divided into an observation group and a control group(40 cases each)using a random number table.The control group received routine high-risk pregnancy nursing care,while the observation group received specialized maternal-infant separation nursing interventions in addition to routine care.The psychological and physiological states and nursing satisfaction of the two groups were compared before and after the intervention.Results:The SAS scores,SDS scores,and sleep quality scores of the observation group were significantly lower than those of the control group,with statistically significant differences(p<0.05).The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the initiation time of lactation was significantly earlier than that in the control group,with both differences being statistically significant(p<0.05).The nursing satisfaction of the observation group was significantly higher than that of the control group(80%vs.32/40),with a statistically significant difference(p<0.05).Conclusion:Maternal-infant separation exacerbates anxiety and depression in high-risk pregnancy patients,reduces sleep quality,increases the risk of postpartum hemorrhage,and delays the initiation of lactation.Specialized nursing interventions for maternal-infant separation can improve the physical and mental state of high-risk pregnancy patients,reduce the incidence of postpartum complications,and enhance nursing satisfaction,making them worthy of clinical application and promotion.展开更多
Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Accept...Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Acceptance Model(TAM). Employing quantitative research methods, the study conducted empirical tests based on 367 valid questionnaires using Partial Least Squares Structural Equation Modeling(PLS-SEM) via SmartPLS 4.0 software. Results indicate that significant associations exist between perceived ease of use, perceived usefulness, attitudes toward use, behavioral intention, and actual usage behavior. Specifically, the study finds that rural women's perceived ease of use of social media has a significant and positive influence on both perceived usefulness and attitudes toward use. Perceived usefulness further significantly promotes attitudes toward use and behavioral intention. Moreover, positive attitudes toward usage and strong behavioral intentions were effectively converted into actual social media usage behaviors. This study not only validates the applicability and explanatory power of the TAM model in understanding the digital behavior of Chinese rural women but also provides quantitative evidence for how social media enhances their “digital visibility.” These findings offer practical insights for governments and platform providers to optimize user experiences and strengthen digital skills training. Despite its limitations, including a cross-sectional design and a regional sample, this research holds significant theoretical and practical implications.展开更多
Objective Accurately identifying the key influencing factors of psychological birth trauma in primiparous women is crucial for implementing effective preventive and intervention measures.This study aimed to develop an...Objective Accurately identifying the key influencing factors of psychological birth trauma in primiparous women is crucial for implementing effective preventive and intervention measures.This study aimed to develop and validate an interpretable machine learning prediction model for identifying the key influencing factors of psychological birth trauma in primiparous women.Methods A multicenter cross-sectional study was conducted on primiparous women in four tertiary hospitals in Sichuan Province,southwestern China,from December 2023 to March 2024.The Childbirth Trauma Index was used in assessing psychological birth trauma in primiparous women.Data were collected and randomly divided into a training set(80%,n=289)and a testing set(20%,n=73).Six different machine learning models were trained and tested.Training and prediction were conducted using six machine learning models included Linear Regression,Support Vector Regression,Multilayer Perceptron Regression,eXtreme Gradient Boosting Regression,Random Forest Regression,and Adaptive Boosting Regression.The optimal model was selected based on various performance metrics,and its predictive results were interpreted using SHapley Additive exPlanations(SHAP)and accumulated local effects(ALE).Results Among the six machine learning models,the Multilayer Perceptron Regression model exhibited the best overall performance in the testing set(MAE=3.977,MSE=24.832,R2=0.507,EVS=0.524,RMSE=4.983).In the testing set,the R2 and EVS of the Multilayer Perceptron Regression model increased by 8.3%and 1.2%,respectively,compared to the traditional linear regression model.Meanwhile,the MAE,MSE,and RMSE decreased by 0.4%,7.3%,and 3.7%,respectively,compared to the traditional linear regression model.The SHAP analysis indicated that intrapartum pain,anxiety,postpartum pain,resilience,and planned pregnancy are the most critical influencing factors of psychological birth trauma in primiparous women.The ALE analysis indicated that higher intrapartum pain,anxiety,and postpartum pain scores are risk factors,while higher resilience scores are protective factors.Conclusions Interpretable machine learning prediction models can identify the key influencing factors of psychological birth trauma in primiparous women.SHAP and ALE analyses based on the Multilayer Perceptron Regression model can help healthcare providers understand the complex decision-making logic within a prediction model.This study provides a scientific basis for the early prevention and personalized intervention of psychological birth trauma in primiparous women.展开更多
Objective:Pelvic floor dysfunction is common among pregnant and postpartum women and significantly impacts quality of life.This study aims to translate the German Pelvic Floor Questionnaire for Pregnant and Postpartum...Objective:Pelvic floor dysfunction is common among pregnant and postpartum women and significantly impacts quality of life.This study aims to translate the German Pelvic Floor Questionnaire for Pregnant and Postpartum Women into Chinese and to evaluate its reliability and validity in the Chinese population.Methods:The questionnaire was translated using the Brislin model.A cross-sectional study was conducted among pregnant and postpartum women to assess the content validity,construct validity,Cronbach’sαcoefficient,test-retest reliability,and split-half reliability of the Chinese version.Results:A total of 72 women were included,with 6.9% being pregnant and 93.1% postpartum;the age was(32.3±3.6)years.The Chinese version of the questionnaire contains 4 dimensions and 45 items.The content validity index of individual items ranged from 0.833 to 1.000,with a scale-level content validity index of 0.977 and intraclass correlation coefficients(ICCs)exceeding 0.90.The overall Cronbach’s α coefficient was 0.891,with subscale coefficients ranging from 0.732 to 0.884(all ICCs>0.70).The testretest reliability of the total scale was 0.833,and for the 4 dimensions,bladder,bowel,prolapse,and sexual function,the values were 0.776,0.579,0.732,and 0.645,respectively.The split-half reliability was 0.74.Conclusion:The Chinese version of the questionnaire demonstrated good reliability and validity,indicating its applicability in assessing pelvic floor dysfunction and associated risk factors during pregnancy and postpartum.展开更多
Introduction: Considering a disease of postmenopausal women, there is a noted trend of increasing breast cancer cases among premenopausal women. Our study aimed to determine the main risk factors for breast cancer in ...Introduction: Considering a disease of postmenopausal women, there is a noted trend of increasing breast cancer cases among premenopausal women. Our study aimed to determine the main risk factors for breast cancer in women aged 40 and under. Materials and Methods: This was a case-control study with exhaustive sampling of all respondents with histological proof over a 12-month period, matched by age. For all statistical tests, we used a significance threshold of 5%. Additionally provided are the ORs and their 95% confidence intervals, the mean, and standard deviation. Results: We collected 65 cases and 130 controls. The frequency of breast cancer in women aged 40 and under was 35.5%. The mean age was 35.6 ± 4.5 years among cases compared to 32.1 ± 7.9 years among controls. A significantly positive association was detected in both univariate and multivariate analysis between age and breast cancer [(OR) = 10.30;95% CI (1.99 - 53.23)] and [(OR) = 7.53;95% CI (1.82 - 31.23)];family history of breast cancer and breast cancer [(OR) = 9.99;95% CI (1.43 - 69.58)];smoking and breast cancer [OR = 13.11;95% CI (1.05 - 163.30)];sedentary lifestyle and breast cancer [OR = 3.36;95% CI (1.01 - 11.17)];and night work and breast cancer [(OR) = 72.05;95% CI (8.15 - 637.25)]. Conclusion: Earlier systematic screening and regular follow-up should be conducted in young women in our context.展开更多
Introduction: Access to the best quality of obstetrical care sometimes conceals acts and behaviors that fail to respect women’s physical, mental and social integrity. These negative experiences are referred to as obs...Introduction: Access to the best quality of obstetrical care sometimes conceals acts and behaviors that fail to respect women’s physical, mental and social integrity. These negative experiences are referred to as obstetrical violence. The aim of this study is to contribute to improving the quality of maternal health care. Patient and Method: This was a cross-sectional study with a quantitative component carried out in the obstetrics and gynecology department of the Maman Elisabeth Domitien University Hospital from November 1 to 30, 2024. All women in childbed seen for postnatal consultations within 42 days of delivery were included. Results: We included 109 women. Age ranged from 16 to 44 years with a mean of 26.9 (±6.02). The majority of women were living in common-law unions with 79.8% and 57.8% of mothers having a secondary education level. More than half of the participants (52.9%) said that they had not been prepared for childbirth during prenatal follow-up and 44.0% had not freely chosen their path of delivery. The vaginal route was the most observed route of delivery (97.3%). Of all vaginal deliveries, episiotomy was performed in 21.7% and uterine revision in 66.0%. For episiotomies, 26.1% of women in childbed were informed about its performance and 87.0% had had a bad experience with this event. For women who had undergone a uterine revision, 52.9% had been informed of its performance and 77.1% had a bad experience with the event. Women in childbed had been victims of inappropriate acts and verbal aggression in 18.4% and 14.7% respectively. Of all the participants, 45.0% said they had experienced the birth episode badly. Conclusion: This study has given us an idea of the subject. However, a large-scale study will enable us to understand the different facets of this subject.展开更多
Objective: This study aims to analyze the distribution of positive human papillomavirus (HPV) infections among women of appropriate age in Beiliu City during cervical cancer screening in 2024, providing data support f...Objective: This study aims to analyze the distribution of positive human papillomavirus (HPV) infections among women of appropriate age in Beiliu City during cervical cancer screening in 2024, providing data support for subsequent public health interventions. Methods: A retrospective analysis was conducted on the HPV test results from January 1, 2024, to November 30, 2024, at Beiliu Maternal and Child Health Hospital. We statistically analyzed the positive rates of different HPV genotypes and the co-infection status of multiple genotypes. Results: A total of 7558 individuals were tested, with 1103 positive cases identified, resulting in a positivity rate of 14.59%. Among these, HPV type 52 had the highest positive rate, accounting for 18.47%. The co-infection analysis showed that there were 788 cases with single genotype positivity, 236 with double genotype positivity, and 58 with triple genotype positivity, while cases with multiple genotypes simultaneously positive were relatively rare. Conclusion: The HPV infection rate among women of appropriate age in Beiliu City is relatively high, especially for high-risk HPV types. To reduce the future incidence of cervical cancer, it is recommended to enhance health education and vaccination efforts for this population.展开更多
As the 30th anniversary of the landmark Beijing Fourth World Conference on Women approaches,the forthcoming 2025 World Women's Summit in Beijing offers a timely platform to reaffirm commitments to women's well...As the 30th anniversary of the landmark Beijing Fourth World Conference on Women approaches,the forthcoming 2025 World Women's Summit in Beijing offers a timely platform to reaffirm commitments to women's well-being worldwide.In alignment with this milestone,Cancer Biology&Medicine is proud to present this special issue dedicated to accelerating the global elimination of cervical cancer.展开更多
BACKGROUND MicroRNAs play a key role in regulating gene expression in human cells.Singlenucleotide variants in these molecules have been linked to cancer development,particularly breast cancer(BrC).AIM To analyze the ...BACKGROUND MicroRNAs play a key role in regulating gene expression in human cells.Singlenucleotide variants in these molecules have been linked to cancer development,particularly breast cancer(BrC).AIM To analyze the association of three microRNA polymorphisms with the risk of BrC in women from western Mexico.METHODS This case-control study included 71 women diagnosed with BrC and 215 women without BrC.Genotypes were determined using a real-time polymerase chain reaction allelic discrimination assay.Multiple genetic models-dominant,recessive,over-dominant,additive,and multiple comparison-were applied to assess the risk.RESULTS The over-dominant model showed that the C/T genotype of MIR196A2(rs11614913)is a protective factor against the ductal histological subtype of BrC in women from western Mexico[odds ratio(OR)=0.4687,95%confidence interval(CI):0.2205-0.9963,P=0.0489].A protective effect was also observed for the C/A genotype(OR=0.2612,95%CI:0.0900-0.7582,P=0.0135)and A allele(OR=0.2826,95%CI:0.0993-0.8044,P=0.0179)of MIR618(rs2682818).No significant association was found between MIR200C(rs73262897)and BrC risk.CONCLUSION The C/T genotype of rs11614913 in MIR196A2,and C/A genotype and A allele of rs2682818 in MIR618,are associated with a protective effect against BrC in women from western Mexico.展开更多
Purpose: There is a significant rise in mortality rates from breast and cervical cancers in Low- and Middle-Income Countries. In Ghana, approximately 4482 women are diagnosed with these diseases at advanced stages. Un...Purpose: There is a significant rise in mortality rates from breast and cervical cancers in Low- and Middle-Income Countries. In Ghana, approximately 4482 women are diagnosed with these diseases at advanced stages. Unfortunately, the early detection rate for these cancers is low compared to other women’s health services. This situation underscores the need to identify the locations of reproductive-age women who have not been screened for these cancers, to implement targeted public health interventions. This study aims to pinpoint these women’s locations for tailored interventions. Method: Bivariate analysis assessed the relationship between the independent and outcome variables. Hot spot analysis and Kriging Ordinary interpolation were employed to pinpoint the locations of these women. Results: Breast cancer examination and cervical cancer test rates were low, with a strong association between the two screening services. Several significant variables were identified: place of residence (p Conclusion: Low participation in these screening services was related to women’s age and the outreach efforts of fieldworkers. Breast and cervical cancer screenings are interconnected and could be combined to improve attendance rates. The Community-based Health Planning and Services (CHPS) implementation strategy could be cost-effective for screening women through targeted interventions, especially in identified clusters.展开更多
The 19th century was a significant period for feminine literature.Louisa May Alcott,a representative female writer of the time,created numerous romance novels.Her masterpiece Little Women follows the growth experience...The 19th century was a significant period for feminine literature.Louisa May Alcott,a representative female writer of the time,created numerous romance novels.Her masterpiece Little Women follows the growth experiences of the four March sisters and illustrates their the pursuit of independence under family education.This paper will analyze how family education impacts the characters’growth and explore the formation of female independence.展开更多
Economic violence is a form of domestic violence that extends beyond physical harm,affecting victims’economic stability and independence.This situation perpetuates gender inequality and also reinforces the cycle of g...Economic violence is a form of domestic violence that extends beyond physical harm,affecting victims’economic stability and independence.This situation perpetuates gender inequality and also reinforces the cycle of gender-based violence.With definitions of economic violence broadening to encompass a range of coercive and manipulative behaviors-from financial abuse in domestic violence scenarios to the economic harassment faced by stay-at-home moms-understanding this form of exploitation is crucial for crafting effective interventions.This article aims to delve into various facets of economic violence,including its definition,prevalence,and the stark realities it creates for its victims.Following the search of international databases:Social Work Abstracts(EBSCO),Psychology Abstracts,Family and Women Studies Worldwide,Psychiatry Online,Psych INFO(including Psych ARTICLES),PubMed,Wiley,and Scopus,60 peer-reviewed articles that met all inclusion criteria were included in the paper.Our review clarifies that looking forward,the call for a comprehensive understanding of economic violence,enhanced legal frameworks,and the strengthening of supportive networks underscore the multidisciplinary approach required to combat this issue effectively.展开更多
Objective:This study aims to determine the effectiveness of giving a combination of Fe tablets and beetroot juice in increasing hemoglobin(Hb)levels of pregnant women with anemia in the Mataram City area.Methods:This ...Objective:This study aims to determine the effectiveness of giving a combination of Fe tablets and beetroot juice in increasing hemoglobin(Hb)levels of pregnant women with anemia in the Mataram City area.Methods:This study was designed with quasi-experimental design with pre-test and post-test with control design.The location of this study was conducted in the city of Mataram on pregnant women with anemia.The sample of this study was pregnant women with mild anemia based on inclusion and exclusion criteria,divided into 2 groups:a control group and a treatment group of 15 respondents each,bringing the total respondents to 30 people.Analysis of Hb level measurement results was carried out using the independent sample t-test.Results:The results obtained in the treatment group(combination of beet juice and Fe tablets)were the mean pre-test of 9.93 mg/dL and post-test of 11.90 mg/dL(P-value=0.000),which means there is effectiveness in increasing hemoglobin levels while in the control group.Comparison of increased Hb levels of the control group and significantly different treatments marked by a P value of 0.001.Conclusions:the combination of Fe tablets and beetroot juice is effective in increasing Hb levels of pregnant women with anemia in the Mataram City area.展开更多
Cervical cancer poses a serious threat to women’s health.Persistent high-risk HPV infection is a necessary factor for cervical cancer development and has become a serious public health threat to women.HPV vaccination...Cervical cancer poses a serious threat to women’s health.Persistent high-risk HPV infection is a necessary factor for cervical cancer development and has become a serious public health threat to women.HPV vaccination is an effective method of preventing HPV infections and related diseases,and it is the primary prophylactic measure for preventing diseases associated with HPV infection.The purpose of this project is to identify the reasons for the low HPV vaccination rate among women aged 30-49 years in Shenzhen,carry out targeted publicity and education on HPV screening and vaccination knowledge,improve the HPV infection screening rate and vaccination rate,reduce the occurrence of cervical cancer,and promote the reproductive health of women of childbearing age.Through lectures,posters,media and other forms of health education,let them understand the knowledge of cervical cancer and form a good healthy lifestyle.展开更多
Objective: To investigate the effect of a self-developed balance rhythm dance program on the rehabilitation of motor function and the reduction of fall risk in elderly women with diminished balance function. Methods: ...Objective: To investigate the effect of a self-developed balance rhythm dance program on the rehabilitation of motor function and the reduction of fall risk in elderly women with diminished balance function. Methods: Fifty elderly women with reduced balance function, admitted to the Qingbar Elderly Care Center of Chongqing Medical University from December 2022 to December 2023, were randomly selected and divided into two groups. The aerobic exercise group (25 patients) received traditional treatment and rehabilitation nursing, while the balance rhythm dance intervention group (25 patients) received the balance rhythm dance intervention in addition to traditional treatment and rehabilitation nursing. The Unified Parkinson’s Disease Rating Scale (UPDRS) and Berg Balance Scale (BBS) were used as evaluation indicators to compare the intervention effects between the two groups. Results: The data revealed that the balance rhythm dance intervention significantly improved the motor ability and balance function of elderly women in the intervention group (P < 0.01), with statistically significant differences observed. Conclusion: The balance rhythm dance program plays a critical role in promoting the rehabilitation of motor function and balance ability in elderly women, effectively enhancing their quality of life.展开更多
BACKGROUND Depression is one of the most common mental disorders,with high rates of disability,particularly among women.AIM To explore the effects of suggestion therapy on anxiety,mood,and sleep-quality in middle-aged...BACKGROUND Depression is one of the most common mental disorders,with high rates of disability,particularly among women.AIM To explore the effects of suggestion therapy on anxiety,mood,and sleep-quality in middle-aged women with depression treated with escitalopram.METHODS Overall,102 female patients with depression aged 35-49 years were divided into control and experimental groups.The control group received oral escitalopram therapy,starting at a dose of 5 mg/day,which was gradually increased to 10-20 mg/day after 1 week for a total of 8 weeks.The experimental group received the suggested therapy based on the control group.The Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),Profile of Mood States-Short Form,and Pittsburgh Sleep Quality Index(PSQI)were used to assess depression,anxiety,mood status,and sleep quality.RESULTS Before treatment,there were no significant differences in the SDS,SAS,Profile of Mood States,and PSQI scores between the two groups(P>0.05).After treatment,compared to the control group and baseline,the SDS,SAS,tension-anxiety,depression-dejection,and confusion-bewilderment scores in the experimental group significantly decreased(P<0.05),whereas sleep efficiency,sleep disturbance,hypnotics,and PSQI scores significantly increased(P<0.05).CONCLUSION Suggestion therapy combined with escitalopram treatment can reduce the severity of depression and anxiety,change mood status,and improve sleep quality in middle-aged women with depression.展开更多
Depression is the most common mental disorder among perinatal women,with its incidence showing an annual increasing trend.Depression poses severe harms to the health of mothers and infants,thus requiring high attentio...Depression is the most common mental disorder among perinatal women,with its incidence showing an annual increasing trend.Depression poses severe harms to the health of mothers and infants,thus requiring high attention from perinatal women themselves,their families,and society.Studies have shown that there are numerous influencing factors for depression in perinatal women,the most common of which include place of residence,monthly family income,recent appetite,mother-in-law and daughter-in-law relationship,personal history of anxiety and depression,obstetric complications during pregnancy,fear of childbirth,utilization of support,positive coping,and susceptible personality.Based on empirical research,this paper conducts an in-depth study and discussion on the current status of depression and its influencing factors in perinatal women,aiming to provide a basis for formulating scientific and effective preventive and intervention measures,and to contribute modestly to effectively reducing the adverse impact of depression on the physical and mental health of mothers and infants.展开更多
基金supported by Joint Program on Health Science&Technology Innovation of Hainan Province(WSJK2024QN093)Discipline Leader Development Program for Outstanding Talents of Hainan West Central Hospital.
文摘Objectives:Postmenopausal women with stress urinary incontinence(SUI)exhibit low androgen expression.This study aimed to evaluate the efficacy and safety of vaginal androgen combined with pelvic floor muscle training(PFMT)in the treatment of SUI in postmenopausal women.Methods:Postmenopausal women with SUI were recruited from Hainan West Central Hospital between January 2024 and March 2025.Participants were randomly assigned in a double-blind manner to receive either vaginal androgen cream combined with PFMT(treatment group)or a visually identical placebo cream(without androgens)combined with PFMT(control group).The vaginal cream was applied to the vaginal wall at a dose of 0.5 g per application,twice weekly for a total of 10 applications,while PFMT was conducted for 8 weeks.The clinical efficacy and safety were compared between the two groups.Results:A total of 61 patients were finally enrolled,with 31 in the treatment group and 30 in the control group.At both 3-month and 6-month follow-ups,the treatment group demonstrated significantly lower values in daily pad usage(p<0.05),24-h pad test scores(p<0.05),and ICIQ-UI SF scores(p<0.05)compared to the control group.The improvement rate of urinary incontinence was significantly higher in the treatment group(p<0.05).Compared to baseline,the treatment group showed statistically significant reductions in all three outcome measures(all p<0.05).No severe adverse events were reported in either group during the treatment period.Conclusions:Androgen therapy combined with PFMT significantly improved the urinary incontinence remission rate in postmenopausal women with SUI,with no severe adverse effects observed.These findings suggest that androgen therapy may represent a novel therapeutic approach for SUI management in postmenopausal women.
基金supported by the National Key R&D Program of China(Nos.2018YFC1004300 and 2018YFC1004302)the Science&Technology Program of Guizhou Province(Nos.QKHHBZ[2020]3002,QKHPTRC-GCC[2022]039-1 and QKHPTRCCXTD[2022]014)the Scientific Research Program of Guizhou Provincial Department of Education(No.QJJ[2023]019).
文摘Despite the widespread presence and frequent detection of polycyclic aromatic hydrocarbons(PAHs)in various aspects of life,there is limited research on their exposure levels in pregnant women and cumulative exposure from the living environment.This study included 1311 women in late pregnancy from the Zunyi birth cohort and measured the urinary concentrations of 10 hydroxylated PAH metabolites(OH-PAHs).Risk assessment was conducted based on the estimated daily intake to calculate the hazard quotient and hazard index(HI).A linear regression model was used to analyze the relationship between creatinine-adjusted OH-PAHs concentrations and living environment and lifestyle factors,while principal component analysis was applied to trace the sources of PAHs exposure.1-OHPYR was detected in all participants’urine,with naphthalene metabolites having the highest concentrations among creatinine-adjusted PAHs.OH-PAHs concentrations were associated with housing type,room number,cooking frequency,household size,exercise frequency,fuel type,distance from main road,and drinking water source.Pregnant women using traditional fuels and living in bungalows had higher health risks than those using clean energy and living in buildings.Those living within 100 m of a main road had higher HI than those farther away.Coal combustion was identified as the primary source of PAHs exposure.The study emphasizes the importance of reducing PAHs exposure,especially for pregnant women living in polluted environments.It recommends public health interventions such as improving indoor ventilation and providing clean energy to reduce related health risks.
文摘Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 high-risk pregnancy patients treated in our hospital from January 2023 to January 2024 were selected as the study subjects.These patients were randomly divided into an observation group and a control group(40 cases each)using a random number table.The control group received routine high-risk pregnancy nursing care,while the observation group received specialized maternal-infant separation nursing interventions in addition to routine care.The psychological and physiological states and nursing satisfaction of the two groups were compared before and after the intervention.Results:The SAS scores,SDS scores,and sleep quality scores of the observation group were significantly lower than those of the control group,with statistically significant differences(p<0.05).The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the initiation time of lactation was significantly earlier than that in the control group,with both differences being statistically significant(p<0.05).The nursing satisfaction of the observation group was significantly higher than that of the control group(80%vs.32/40),with a statistically significant difference(p<0.05).Conclusion:Maternal-infant separation exacerbates anxiety and depression in high-risk pregnancy patients,reduces sleep quality,increases the risk of postpartum hemorrhage,and delays the initiation of lactation.Specialized nursing interventions for maternal-infant separation can improve the physical and mental state of high-risk pregnancy patients,reduce the incidence of postpartum complications,and enhance nursing satisfaction,making them worthy of clinical application and promotion.
文摘Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Acceptance Model(TAM). Employing quantitative research methods, the study conducted empirical tests based on 367 valid questionnaires using Partial Least Squares Structural Equation Modeling(PLS-SEM) via SmartPLS 4.0 software. Results indicate that significant associations exist between perceived ease of use, perceived usefulness, attitudes toward use, behavioral intention, and actual usage behavior. Specifically, the study finds that rural women's perceived ease of use of social media has a significant and positive influence on both perceived usefulness and attitudes toward use. Perceived usefulness further significantly promotes attitudes toward use and behavioral intention. Moreover, positive attitudes toward usage and strong behavioral intentions were effectively converted into actual social media usage behaviors. This study not only validates the applicability and explanatory power of the TAM model in understanding the digital behavior of Chinese rural women but also provides quantitative evidence for how social media enhances their “digital visibility.” These findings offer practical insights for governments and platform providers to optimize user experiences and strengthen digital skills training. Despite its limitations, including a cross-sectional design and a regional sample, this research holds significant theoretical and practical implications.
基金supported by the Sichuan Province Nursing Scientific Research Project Plan(H23022)the 2022 Municipal-University Science and Technology Strategic Cooperation Special Fund of Nanchong Science and Technology Bureau(22SXQT0222)。
文摘Objective Accurately identifying the key influencing factors of psychological birth trauma in primiparous women is crucial for implementing effective preventive and intervention measures.This study aimed to develop and validate an interpretable machine learning prediction model for identifying the key influencing factors of psychological birth trauma in primiparous women.Methods A multicenter cross-sectional study was conducted on primiparous women in four tertiary hospitals in Sichuan Province,southwestern China,from December 2023 to March 2024.The Childbirth Trauma Index was used in assessing psychological birth trauma in primiparous women.Data were collected and randomly divided into a training set(80%,n=289)and a testing set(20%,n=73).Six different machine learning models were trained and tested.Training and prediction were conducted using six machine learning models included Linear Regression,Support Vector Regression,Multilayer Perceptron Regression,eXtreme Gradient Boosting Regression,Random Forest Regression,and Adaptive Boosting Regression.The optimal model was selected based on various performance metrics,and its predictive results were interpreted using SHapley Additive exPlanations(SHAP)and accumulated local effects(ALE).Results Among the six machine learning models,the Multilayer Perceptron Regression model exhibited the best overall performance in the testing set(MAE=3.977,MSE=24.832,R2=0.507,EVS=0.524,RMSE=4.983).In the testing set,the R2 and EVS of the Multilayer Perceptron Regression model increased by 8.3%and 1.2%,respectively,compared to the traditional linear regression model.Meanwhile,the MAE,MSE,and RMSE decreased by 0.4%,7.3%,and 3.7%,respectively,compared to the traditional linear regression model.The SHAP analysis indicated that intrapartum pain,anxiety,postpartum pain,resilience,and planned pregnancy are the most critical influencing factors of psychological birth trauma in primiparous women.The ALE analysis indicated that higher intrapartum pain,anxiety,and postpartum pain scores are risk factors,while higher resilience scores are protective factors.Conclusions Interpretable machine learning prediction models can identify the key influencing factors of psychological birth trauma in primiparous women.SHAP and ALE analyses based on the Multilayer Perceptron Regression model can help healthcare providers understand the complex decision-making logic within a prediction model.This study provides a scientific basis for the early prevention and personalized intervention of psychological birth trauma in primiparous women.
基金supported by the Natural Science Foundation of Hunan Province(2024JJ6626)the Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control(HPKL202320),China.
文摘Objective:Pelvic floor dysfunction is common among pregnant and postpartum women and significantly impacts quality of life.This study aims to translate the German Pelvic Floor Questionnaire for Pregnant and Postpartum Women into Chinese and to evaluate its reliability and validity in the Chinese population.Methods:The questionnaire was translated using the Brislin model.A cross-sectional study was conducted among pregnant and postpartum women to assess the content validity,construct validity,Cronbach’sαcoefficient,test-retest reliability,and split-half reliability of the Chinese version.Results:A total of 72 women were included,with 6.9% being pregnant and 93.1% postpartum;the age was(32.3±3.6)years.The Chinese version of the questionnaire contains 4 dimensions and 45 items.The content validity index of individual items ranged from 0.833 to 1.000,with a scale-level content validity index of 0.977 and intraclass correlation coefficients(ICCs)exceeding 0.90.The overall Cronbach’s α coefficient was 0.891,with subscale coefficients ranging from 0.732 to 0.884(all ICCs>0.70).The testretest reliability of the total scale was 0.833,and for the 4 dimensions,bladder,bowel,prolapse,and sexual function,the values were 0.776,0.579,0.732,and 0.645,respectively.The split-half reliability was 0.74.Conclusion:The Chinese version of the questionnaire demonstrated good reliability and validity,indicating its applicability in assessing pelvic floor dysfunction and associated risk factors during pregnancy and postpartum.
文摘Introduction: Considering a disease of postmenopausal women, there is a noted trend of increasing breast cancer cases among premenopausal women. Our study aimed to determine the main risk factors for breast cancer in women aged 40 and under. Materials and Methods: This was a case-control study with exhaustive sampling of all respondents with histological proof over a 12-month period, matched by age. For all statistical tests, we used a significance threshold of 5%. Additionally provided are the ORs and their 95% confidence intervals, the mean, and standard deviation. Results: We collected 65 cases and 130 controls. The frequency of breast cancer in women aged 40 and under was 35.5%. The mean age was 35.6 ± 4.5 years among cases compared to 32.1 ± 7.9 years among controls. A significantly positive association was detected in both univariate and multivariate analysis between age and breast cancer [(OR) = 10.30;95% CI (1.99 - 53.23)] and [(OR) = 7.53;95% CI (1.82 - 31.23)];family history of breast cancer and breast cancer [(OR) = 9.99;95% CI (1.43 - 69.58)];smoking and breast cancer [OR = 13.11;95% CI (1.05 - 163.30)];sedentary lifestyle and breast cancer [OR = 3.36;95% CI (1.01 - 11.17)];and night work and breast cancer [(OR) = 72.05;95% CI (8.15 - 637.25)]. Conclusion: Earlier systematic screening and regular follow-up should be conducted in young women in our context.
文摘Introduction: Access to the best quality of obstetrical care sometimes conceals acts and behaviors that fail to respect women’s physical, mental and social integrity. These negative experiences are referred to as obstetrical violence. The aim of this study is to contribute to improving the quality of maternal health care. Patient and Method: This was a cross-sectional study with a quantitative component carried out in the obstetrics and gynecology department of the Maman Elisabeth Domitien University Hospital from November 1 to 30, 2024. All women in childbed seen for postnatal consultations within 42 days of delivery were included. Results: We included 109 women. Age ranged from 16 to 44 years with a mean of 26.9 (±6.02). The majority of women were living in common-law unions with 79.8% and 57.8% of mothers having a secondary education level. More than half of the participants (52.9%) said that they had not been prepared for childbirth during prenatal follow-up and 44.0% had not freely chosen their path of delivery. The vaginal route was the most observed route of delivery (97.3%). Of all vaginal deliveries, episiotomy was performed in 21.7% and uterine revision in 66.0%. For episiotomies, 26.1% of women in childbed were informed about its performance and 87.0% had had a bad experience with this event. For women who had undergone a uterine revision, 52.9% had been informed of its performance and 77.1% had a bad experience with the event. Women in childbed had been victims of inappropriate acts and verbal aggression in 18.4% and 14.7% respectively. Of all the participants, 45.0% said they had experienced the birth episode badly. Conclusion: This study has given us an idea of the subject. However, a large-scale study will enable us to understand the different facets of this subject.
文摘Objective: This study aims to analyze the distribution of positive human papillomavirus (HPV) infections among women of appropriate age in Beiliu City during cervical cancer screening in 2024, providing data support for subsequent public health interventions. Methods: A retrospective analysis was conducted on the HPV test results from January 1, 2024, to November 30, 2024, at Beiliu Maternal and Child Health Hospital. We statistically analyzed the positive rates of different HPV genotypes and the co-infection status of multiple genotypes. Results: A total of 7558 individuals were tested, with 1103 positive cases identified, resulting in a positivity rate of 14.59%. Among these, HPV type 52 had the highest positive rate, accounting for 18.47%. The co-infection analysis showed that there were 788 cases with single genotype positivity, 236 with double genotype positivity, and 58 with triple genotype positivity, while cases with multiple genotypes simultaneously positive were relatively rare. Conclusion: The HPV infection rate among women of appropriate age in Beiliu City is relatively high, especially for high-risk HPV types. To reduce the future incidence of cervical cancer, it is recommended to enhance health education and vaccination efforts for this population.
文摘As the 30th anniversary of the landmark Beijing Fourth World Conference on Women approaches,the forthcoming 2025 World Women's Summit in Beijing offers a timely platform to reaffirm commitments to women's well-being worldwide.In alignment with this milestone,Cancer Biology&Medicine is proud to present this special issue dedicated to accelerating the global elimination of cervical cancer.
基金Supported by Patronage of the Autonomous University of Nayarit,Quality Postgraduate Program with resources from the 15%Special Tax allocated to the UAN 2022.
文摘BACKGROUND MicroRNAs play a key role in regulating gene expression in human cells.Singlenucleotide variants in these molecules have been linked to cancer development,particularly breast cancer(BrC).AIM To analyze the association of three microRNA polymorphisms with the risk of BrC in women from western Mexico.METHODS This case-control study included 71 women diagnosed with BrC and 215 women without BrC.Genotypes were determined using a real-time polymerase chain reaction allelic discrimination assay.Multiple genetic models-dominant,recessive,over-dominant,additive,and multiple comparison-were applied to assess the risk.RESULTS The over-dominant model showed that the C/T genotype of MIR196A2(rs11614913)is a protective factor against the ductal histological subtype of BrC in women from western Mexico[odds ratio(OR)=0.4687,95%confidence interval(CI):0.2205-0.9963,P=0.0489].A protective effect was also observed for the C/A genotype(OR=0.2612,95%CI:0.0900-0.7582,P=0.0135)and A allele(OR=0.2826,95%CI:0.0993-0.8044,P=0.0179)of MIR618(rs2682818).No significant association was found between MIR200C(rs73262897)and BrC risk.CONCLUSION The C/T genotype of rs11614913 in MIR196A2,and C/A genotype and A allele of rs2682818 in MIR618,are associated with a protective effect against BrC in women from western Mexico.
文摘Purpose: There is a significant rise in mortality rates from breast and cervical cancers in Low- and Middle-Income Countries. In Ghana, approximately 4482 women are diagnosed with these diseases at advanced stages. Unfortunately, the early detection rate for these cancers is low compared to other women’s health services. This situation underscores the need to identify the locations of reproductive-age women who have not been screened for these cancers, to implement targeted public health interventions. This study aims to pinpoint these women’s locations for tailored interventions. Method: Bivariate analysis assessed the relationship between the independent and outcome variables. Hot spot analysis and Kriging Ordinary interpolation were employed to pinpoint the locations of these women. Results: Breast cancer examination and cervical cancer test rates were low, with a strong association between the two screening services. Several significant variables were identified: place of residence (p Conclusion: Low participation in these screening services was related to women’s age and the outreach efforts of fieldworkers. Breast and cervical cancer screenings are interconnected and could be combined to improve attendance rates. The Community-based Health Planning and Services (CHPS) implementation strategy could be cost-effective for screening women through targeted interventions, especially in identified clusters.
文摘The 19th century was a significant period for feminine literature.Louisa May Alcott,a representative female writer of the time,created numerous romance novels.Her masterpiece Little Women follows the growth experiences of the four March sisters and illustrates their the pursuit of independence under family education.This paper will analyze how family education impacts the characters’growth and explore the formation of female independence.
文摘Economic violence is a form of domestic violence that extends beyond physical harm,affecting victims’economic stability and independence.This situation perpetuates gender inequality and also reinforces the cycle of gender-based violence.With definitions of economic violence broadening to encompass a range of coercive and manipulative behaviors-from financial abuse in domestic violence scenarios to the economic harassment faced by stay-at-home moms-understanding this form of exploitation is crucial for crafting effective interventions.This article aims to delve into various facets of economic violence,including its definition,prevalence,and the stark realities it creates for its victims.Following the search of international databases:Social Work Abstracts(EBSCO),Psychology Abstracts,Family and Women Studies Worldwide,Psychiatry Online,Psych INFO(including Psych ARTICLES),PubMed,Wiley,and Scopus,60 peer-reviewed articles that met all inclusion criteria were included in the paper.Our review clarifies that looking forward,the call for a comprehensive understanding of economic violence,enhanced legal frameworks,and the strengthening of supportive networks underscore the multidisciplinary approach required to combat this issue effectively.
基金supported by Muhammadiyah Research Grant (RisetMu) Batch Ⅵ (No. 1687.186/PD/I.3/D/2022)
文摘Objective:This study aims to determine the effectiveness of giving a combination of Fe tablets and beetroot juice in increasing hemoglobin(Hb)levels of pregnant women with anemia in the Mataram City area.Methods:This study was designed with quasi-experimental design with pre-test and post-test with control design.The location of this study was conducted in the city of Mataram on pregnant women with anemia.The sample of this study was pregnant women with mild anemia based on inclusion and exclusion criteria,divided into 2 groups:a control group and a treatment group of 15 respondents each,bringing the total respondents to 30 people.Analysis of Hb level measurement results was carried out using the independent sample t-test.Results:The results obtained in the treatment group(combination of beet juice and Fe tablets)were the mean pre-test of 9.93 mg/dL and post-test of 11.90 mg/dL(P-value=0.000),which means there is effectiveness in increasing hemoglobin levels while in the control group.Comparison of increased Hb levels of the control group and significantly different treatments marked by a P value of 0.001.Conclusions:the combination of Fe tablets and beetroot juice is effective in increasing Hb levels of pregnant women with anemia in the Mataram City area.
基金supported by Shenzhen Bao’an District of Medical and Health Research Project(2023JD212)Shenzhen Bao’an District of Traditional Chinese Medicine Clinical Research Project(2023ZYYLCZX-12)+2 种基金Shenzhen“Medical and Health Three Projects”Project Grant(SZZYSM 202106003)Shenzhen Pingshan District of Health System Research Project(Project No:2024334)Weifang Health Committee Scientific Research Project(wfwsjk-2023-170).
文摘Cervical cancer poses a serious threat to women’s health.Persistent high-risk HPV infection is a necessary factor for cervical cancer development and has become a serious public health threat to women.HPV vaccination is an effective method of preventing HPV infections and related diseases,and it is the primary prophylactic measure for preventing diseases associated with HPV infection.The purpose of this project is to identify the reasons for the low HPV vaccination rate among women aged 30-49 years in Shenzhen,carry out targeted publicity and education on HPV screening and vaccination knowledge,improve the HPV infection screening rate and vaccination rate,reduce the occurrence of cervical cancer,and promote the reproductive health of women of childbearing age.Through lectures,posters,media and other forms of health education,let them understand the knowledge of cervical cancer and form a good healthy lifestyle.
基金Chongqing Sports Scientific Research Project“Research and Development of Balance Rhythm Dance and Its Application in Reducing Fall Risk in Older Women”(Project No.D202209)Chongqing Nursing Vocational College College-level Project“Research on the Talent Training Model of Field Engineers in the Intelligent Health Care Sector Based on Rehabilitation Assistive Devices under the‘Integration of Science and Education’Approach”(Project No.Y202307)+1 种基金Chongqing Science and Technology Bureau Research Project“Investigating the Impact of Electro-acupuncture Applied to Antagonist Muscles on Walking Ability in Stroke Patients with Hemiplegia Based on the Principle of Reciprocal Inhibition”(Project No.CSTC2019JXJL130019)Chongqing Traditional Chinese Medicine Hospital Research Project“The Alterations in the Pelvic Floor Muscle Group Following Acupuncture Treatment for Postpartum Stress Urinary Incontinence Were Evaluated Using SWE Technology”(Project No.jxyn2021-2-23)。
文摘Objective: To investigate the effect of a self-developed balance rhythm dance program on the rehabilitation of motor function and the reduction of fall risk in elderly women with diminished balance function. Methods: Fifty elderly women with reduced balance function, admitted to the Qingbar Elderly Care Center of Chongqing Medical University from December 2022 to December 2023, were randomly selected and divided into two groups. The aerobic exercise group (25 patients) received traditional treatment and rehabilitation nursing, while the balance rhythm dance intervention group (25 patients) received the balance rhythm dance intervention in addition to traditional treatment and rehabilitation nursing. The Unified Parkinson’s Disease Rating Scale (UPDRS) and Berg Balance Scale (BBS) were used as evaluation indicators to compare the intervention effects between the two groups. Results: The data revealed that the balance rhythm dance intervention significantly improved the motor ability and balance function of elderly women in the intervention group (P < 0.01), with statistically significant differences observed. Conclusion: The balance rhythm dance program plays a critical role in promoting the rehabilitation of motor function and balance ability in elderly women, effectively enhancing their quality of life.
文摘BACKGROUND Depression is one of the most common mental disorders,with high rates of disability,particularly among women.AIM To explore the effects of suggestion therapy on anxiety,mood,and sleep-quality in middle-aged women with depression treated with escitalopram.METHODS Overall,102 female patients with depression aged 35-49 years were divided into control and experimental groups.The control group received oral escitalopram therapy,starting at a dose of 5 mg/day,which was gradually increased to 10-20 mg/day after 1 week for a total of 8 weeks.The experimental group received the suggested therapy based on the control group.The Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),Profile of Mood States-Short Form,and Pittsburgh Sleep Quality Index(PSQI)were used to assess depression,anxiety,mood status,and sleep quality.RESULTS Before treatment,there were no significant differences in the SDS,SAS,Profile of Mood States,and PSQI scores between the two groups(P>0.05).After treatment,compared to the control group and baseline,the SDS,SAS,tension-anxiety,depression-dejection,and confusion-bewilderment scores in the experimental group significantly decreased(P<0.05),whereas sleep efficiency,sleep disturbance,hypnotics,and PSQI scores significantly increased(P<0.05).CONCLUSION Suggestion therapy combined with escitalopram treatment can reduce the severity of depression and anxiety,change mood status,and improve sleep quality in middle-aged women with depression.
基金Study on the Construction of a Perinatal Depression Risk Prediction Model Based on Artificial Neural Network,2023 Xiangjiao Tong(Project No.:361-23c0467)。
文摘Depression is the most common mental disorder among perinatal women,with its incidence showing an annual increasing trend.Depression poses severe harms to the health of mothers and infants,thus requiring high attention from perinatal women themselves,their families,and society.Studies have shown that there are numerous influencing factors for depression in perinatal women,the most common of which include place of residence,monthly family income,recent appetite,mother-in-law and daughter-in-law relationship,personal history of anxiety and depression,obstetric complications during pregnancy,fear of childbirth,utilization of support,positive coping,and susceptible personality.Based on empirical research,this paper conducts an in-depth study and discussion on the current status of depression and its influencing factors in perinatal women,aiming to provide a basis for formulating scientific and effective preventive and intervention measures,and to contribute modestly to effectively reducing the adverse impact of depression on the physical and mental health of mothers and infants.
