By considering numerical features, spatial variation, and spatial association, the spatial patterns of China's irrigation water withdrawals in 2001 and 2010 were explored at the regional, provincial, and prefectur...By considering numerical features, spatial variation, and spatial association, the spatial patterns of China's irrigation water withdrawals in 2001 and 2010 were explored at the regional, provincial, and prefectural scales. In addition, an overlay analysis was used to develop specific water-saving guidance for areas under different levels of water stress and with different degrees of irrigation water withdrawals. It was found that at the regional scale, irrigation water withdrawals were highest in the Middle-Lower Yangtze River region in both years, while at the provincial scale, the largest irrigation water withdrawals occurred in Xinjiang. During 2001–2010, the total of irrigation water withdrawals decreased; however, in the Northeast region, especially in Heilongjiang Province, it experienced a dramatic increase. The spatial variation was largest at the prefectural scale, with an apparent effect. The spatial association was globally negative at the provincial scale, and Xinjiang was the only significant high-low outlier. In contrast, the association displayed a significant positive relationship at the prefectural scale, and several clusters and outliers were detected. Finally, it was found that the water stress in the northern part of China worsened and water-saving irrigation techniques urgently need to be applied in the Northeast region, the Huang-Huai-Hai Plain region, and Gansu-Xinjiang region. This study verified that a multi-scale and aspect analysis of the spatial patterns of irrigation water withdrawals were essential and provided water-saving advice for different areas.展开更多
The amount of water withdrawn by wells is one of the quantitative variables that can be applied to estimate groundwater resources and further evaluate the human influence on groundwater systems. The accuracy for the c...The amount of water withdrawn by wells is one of the quantitative variables that can be applied to estimate groundwater resources and further evaluate the human influence on groundwater systems. The accuracy for the calculation of the amount of water withdrawal significantly influences the regional groundwater resource evaluation and management. However, the decentralized groundwater pumping, inefficient management, measurement errors and uncertainties have resulted in considerable errors in the groundwater withdrawal estimation. In this study, to improve the estimation of the groundwater withdrawal, an innovative approach was proposed using an inversion method based on a regional groundwater flow numerical model, and this method was then applied in the North China Plain. The principle of the method was matching the simulated water levels with the observation ones by adjusting the amount of groundwater withdrawal. In addition, uncertainty analysis of hydraulic conductivity and specific yield for the estimation of the groundwater withdrawal was conducted. By using the proposed inversion method, the estimated annual average groundwater withdrawal was approximately 24.92×10^9 m^3 in the North China Plain from 2002 to 2008. The inversion method also significantly improved the simulation results for both hydrograph and the flow field. Results of the uncertainty analysis showed that the hydraulic conductivity was more sensitive to the inversion results than the specific yield.展开更多
With an increase in population and economic development,water withdrawals are close to or even exceed the amount of water available in many regions of the world.Modelling water withdrawals could help water planners im...With an increase in population and economic development,water withdrawals are close to or even exceed the amount of water available in many regions of the world.Modelling water withdrawals could help water planners improve the efficiency of water use,water resources allocation,and management in order to alleviate water crises.However,minimal information has been obtained on how water withdrawals have changed over space and time,especially on a regional or local scale.This research proposes a data-driven framework to help estimate county-level distribution of water withdrawals.Using this framework,spatial statistical methods are used to estimate water withdrawals for agricultural,industrial,and domestic purposes in the Huaihe River watershed in China for the period 1978–2018.Total water withdrawals were found to have more than doubled,from 292.55×10^(8)m^(3) in 1978 to 642.93×10^(8)m^(3) in 2009,and decreased to 602.63×10^(8)m^(3) in 2018.Agricultural water increased from 208.17×10^(8)m^(3) in 1978 to 435.80×10^(8)m^(3) in 2009 and decreased to 360.84×10^(8)m^(3) in 2018.Industrial and domestic water usage constantly increased throughout the 1978–2018 period.In 1978,industrial and domestic demands were 20.35×10^(8)m^(3) and 60.04×10^(8)m^(3),respectively,and up until 2018,the figures were 105.58×10^(8)m^(3) and 136.20×10^(8)m^(3).From a spatial distribution perspective,Moran’s I statistical results show that the total water withdrawal has significant spatial autocorrelation during 1978–2018.The overall trend was a gradual increase in 1978–2010 with withdrawal beginning to decline in 2010–2018.The results of Getis-Ord G_(i)^(*)statistical calculations showed spatially contiguous clusters of total water withdrawal in the Huaihe River watershed during1978–2010,and the spatial agglomeration weakened from 2010 to 2018.This study provides a data-driven framework for assessing water withdrawals to enable a deeper understanding of competing water use among economic sectors as well as water withdrawal modelled with proper data resource and method.展开更多
Objectives:Non-suicidal self-injury(NSSI)represents a prominent and escalating concern within mental health,associated with considerable psychological and physical dangers.Peer victimization is identified as a signifi...Objectives:Non-suicidal self-injury(NSSI)represents a prominent and escalating concern within mental health,associated with considerable psychological and physical dangers.Peer victimization is identified as a significant predictor of NSSI behavior.Although prior research has explored the association between peer victimization and NSSI,the mechanisms underlying this relationship remain insufficiently understood.Utilizing social information processing theory frameworks,the present study seeks to examine the sequential mediating roles of a cognitive factor,future orientation,and a behavioral factor,social withdrawal,in middle school students.Methods:A cross-sectional survey was administered in China,involving 528 participants(261 females and 267 males;Meanage=13.71,standard deviation[SD]=0.93).Participants completed self-report measures assessing peer victimization via the Delaware Bullying Victimization Scale-Student Version,NSSI via the Adolescents Self-Harm Scale,future orientation via the Adolescent Future Orientation Questionnaire,and social withdrawal via the Social Withdrawal Questionnaire.Results:Findings indicated a significant positive correlation between peer victimization and NSSI(r=0.30,p<0.01).Additionally,future orientation and social withdrawal functioned as serial mediators,with an indirect effect of 0.01(95%CI:[0.01,0.02]),representing 2.70%of the total effect(𝛽=0.37,95%CI:[0.25,0.47]).Conclusions:The findings endorse a theoretical framework in which negative future outlook and social withdrawal are sequentially linked within the relationship between peer victimization and NSSI.Although the serial indirect effect observed is modest,it delineates a distinct associative pattern that characterizes adolescents subjected to victimization.These results carry practical significance for school-based intervention programs,indicating that targeting future perspectives and social connections may enhance strategies for preventing NSSI.展开更多
With ever increasing water demands and the continuous intensification of water scarcity arising from China＇s industrialization, the country is struggling to harmonize its industrial development and water supply. This...With ever increasing water demands and the continuous intensification of water scarcity arising from China＇s industrialization, the country is struggling to harmonize its industrial development and water supply. This paper presents a systems analysis of water with- drawals by Chinese industry and investigates demand- driven industrial water uses embodied in final demand and interregional trade based on a multi-regional input-output model. In 2007, the Electric Power, Steam, and Hot Water Production and Supply sector ranks first in direct industrial water withdrawal （DWW）, and Construction has the largest embodied industrial water use （EWU）. Investment, consumption, and exports contribute to 34.6%, 33.3%, and 30.6% of the national total EWU, respectively. Specifically, 58.0%, 51.1%, 48.6%, 43.3%, and 37.5% of the regional EWUs respectively in Guangdong, Shanghai, Zhejiang, Jiangsu, and Fujian are attributed to international exports. The total interregional import/export of embodied water is equivalent to about 40% of the national total DWW, of which 55.5% is associated with the DWWs of Electric Power, Steam, and Hot Water Production and Supply. Jiangsu is the biggest interregional exporter and deficit receiver of embodied water, in contrast to Guangdong as the biggest interregional importer and surplus receiver. Without implementing effective water- saving measures and adjusting industrial structures, the regional imbalance between water availability and water demand tends to intensify considering the water impact of domestic trade of industrial products. Steps taken to improve water use efficiency in production, and to enhance embodied water saving in consumption are both of great significance for supporting China＇s water policies.展开更多
The microstructure of single crystal superalloy is relatively simple,consisting primarily ofγdendrites andγ/γ′eutectics.During the directional solidification process of Ni-based single crystal superalloys,withdraw...The microstructure of single crystal superalloy is relatively simple,consisting primarily ofγdendrites andγ/γ′eutectics.During the directional solidification process of Ni-based single crystal superalloys,withdrawal rate is a critical parameter affecting the spatial distribution ofγ/γ′eutectic along gravity direction.The results show that theγ/γ′eutectic fraction of the upper platform surface is always higher than that of the lower one,regardless of withdrawal rate.As the withdrawal rate decreases,there is a significant increase inγ/γ′eutectic fraction on the upper surface,while it decreases on the lower surface.The upward accumulation ofγ/γ′eutectic becomes more severe as the withdrawal rate decreases.It is also found that the percentage of Al+Ta is positively correlated with theγ/γ′eutectic fraction.Thermo-solute convection of Al and Ta solutes in the solidification front is the prime reason for the non-uniform distribution of eutectic.The non-uniform distribution ofγ/γ′eutectic cannot be eliminated even after subsequent solution heat treatment,resulting in excess eutectic on the upper surface and thus leading to the scrapping of the blade.展开更多
BACKGROUND Glucocorticoids(GC)are the cornerstone in the treatment of severe alcoholassociated hepatitis(SAH)but may be associated with adverse events.CASE SUMMARY We report a prospective series of patients with SAH w...BACKGROUND Glucocorticoids(GC)are the cornerstone in the treatment of severe alcoholassociated hepatitis(SAH)but may be associated with adverse events.CASE SUMMARY We report a prospective series of patients with SAH who were treated with GC and developed de novo arthropathy within 2 weeks of GC cessation.Five patients were included in this series,three of whom were women.All patients underwent ultrasound evaluation and were referred to the Rheumatology Clinics.Final diagnoses were:Arthralgia associated with GC cessation(n=3),polymyalgia rheumatica(n=1)and psoriatic arthritis(n=1).Joint soreness was the main symptom,whereas arthritis occurred rarely.Patients with arthralgia associated with GC cessation required longer regimes of GC and tapering strategies but remained free of symptoms and specific treatment in the long term.CONCLUSION De novo arthropathy may occur following GC for SAH.Close monitoring and tapering regimes are advised.展开更多
BACKGROUND Psychotic disorders are characterized by both positive symptoms(hallucinations,delusions)and negative symptoms(emotional blunting,anhedonia)that impair daily functioning.While antipsychotic drugs and psycho...BACKGROUND Psychotic disorders are characterized by both positive symptoms(hallucinations,delusions)and negative symptoms(emotional blunting,anhedonia)that impair daily functioning.While antipsychotic drugs and psychological interventions are effective when addressing positive symptoms,treatment of negative symptoms remains an ongoing challenge.Mindfulness-based interventions(MBIs)have been shown to reduce negative psychotic symptoms.However,as negative psychotic symptoms are assessed as a sole entity rather than a sum of manifestations,the effect of MBIs remains unclear.AIM To examine the effects of MBI in addition to integrated rehabilitation treatment(IRT)for people experiencing psychosis on each of the negative psychotic symptoms.METHODS A randomized controlled clinical trial with preintervention and postintervention measures was designed.The main outcome variable was negative psychotic symptoms assessed through the seven subscales of the Spanish version of the positive and negative syndrome scale.Data were analyzed using a repeated measures analysis of variance and reliable change index calculation.RESULTS There were no statistical differences between groups at the preintervention assessment.Statistically significant differences were found after MBI for the time in emotional withdrawal(F=37.75,P<0.001,η2=0.437)and social withdrawal(F=37.75,P<0.001,η2=0.437).CONCLUSION MBI added to IRT reduced the lack of interest and involvement with affective commitment to daily life activities,and interest and engagement in social activities increased.These negative psychotic symptoms were not improved by IRT alone.展开更多
BACKGROUND Adenoma detection rate(ADR),a key colonoscopy quality metric,varies with patient demographics and procedural factors.AIM To identify independent predictors of≥25%ADR,develop a risk model,and propose withdr...BACKGROUND Adenoma detection rate(ADR),a key colonoscopy quality metric,varies with patient demographics and procedural factors.AIM To identify independent predictors of≥25%ADR,develop a risk model,and propose withdrawal durations based on different insertion times.METHODS We retrospectively analyzed 830 cases using logistic regression and identified four key factors,validated in a prospective cohort of 5699 patients.Their importance was confirmed using random forest(RF),extreme gradient boosting(XGBoost)and light gradient boosting machine(LightGBM).Attempts to determine targetachieving withdrawal time by grouping cases based on insertion time and Cox regression were inconclusive.Using the 5699-case dataset,we developed a predictive model combining support vector machine(SVM)with XGBoost.We built a Shiny app using this model for clinical application.RESULTS Multivariate logistic regression identified age[odds ratio(OR)=1.05;95%confidence interval(CI):1.03-1.08;P<0.001],male(OR=1.79;95%CI:1.32-2.41;P=0.005),higher endoscopist experience(OR=1.79;95%CI:1.20-2.68;P=0.005),and longer withdrawal time(P<0.001)as independent risk factors for colorectal adenoma.A nomogram demonstrated strong discrimination[area under the curve(AUC)=0.720],with robust calibration and decision-curve performance.Feature importance via RF,XGBoost,and LightGBM confirmed key predictors.A hybrid model combining SVM regression for withdrawal-time estimation and XGBoost classification achieved stable results,with XGBoost reporting AUCs of 0.640 in training and 0.610 in testing,and similar validation outcomes.Deployed via a Shiny app for clinical use.However,model discrimination was modest(AUC:0.61-0.64),suggesting that clinical utility requires further refinement.CONCLUSION A hybrid SVM-XGBoost model using four key endoscopic factors was independently validated and is available as a Shiny app,delivering real-time decision support to streamline endoscopy and enhance clinical outcomes.展开更多
BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To e...BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To evaluate the outcomes of 5-ASA withdrawal due to non-adherence in UC patients while in remission on monotherapy.METHODS Adult patients with UC who were followed up between July 2019 and April 2025 were screened.Patients in remission receiving 5-ASA monotherapy who experienced treatment withdrawal due to non-adherence were included in this study.RESULTS Among 880 patients with UC,30(3.4%)had 5-ASA withdrawal due to nonadherence while in remission on monotherapy.Twelve patients(40%)had disease relapse after a median of 20 months.The rate of patients in remission was 89%in the first year,decreasing to 73%in the second year,and to 64%in the third year.There were no significant differences between patients with and without relapse in terms of demographics,disease extent,remission duration before 5-ASA withdrawal,previous medications,steroid dependence,5-ASA formulation,baseline inflammatory markers,or partial and endoscopic Mayo scores.Most patients(75%)who experienced relapse were successfully treated with 5-ASA monotherapy,while one-fourth of them required corticosteroids.No patients required biologic agents,hospitalization,or surgical intervention.CONCLUSION Intermittent therapy may be safe and feasible for UC patients,especially those in long-term remission,with treatment interruption up to one year considered acceptable.展开更多
This invited commentary discusses the recent study by Atay et al,which investigated relapse rates following the spontaneous withdrawal of maintenance 5-aminosalicylates in ulcerative colitis.The discussion focuses,in ...This invited commentary discusses the recent study by Atay et al,which investigated relapse rates following the spontaneous withdrawal of maintenance 5-aminosalicylates in ulcerative colitis.The discussion focuses,in this patient setting,on the possible reasons that might prompt clinicians to pursue such exit strategies,and on the importance of exercising caution in these decisions,given the extremely narrow subsets of patients for whom international guidelines allow any degree of leeway.展开更多
Existing literature indicates that prolonged insertion time is associated with procedural complexity and may influence adenoma detection.Xu et al recently reported that longer insertion time correlates with lower aden...Existing literature indicates that prolonged insertion time is associated with procedural complexity and may influence adenoma detection.Xu et al recently reported that longer insertion time correlates with lower adenoma detection,but this effect can be mitigated by sufficient withdrawal duration.Insertion time should not be regarded merely as a numeric variable but rather as a multidimensional marker of technical difficulty.Integrating the insertion-to-withdrawal ratio with composite indicators such as looping or bowel preparation quality may enhance predictive models of colonoscopy performance.Conceptualizing insertion time in this way provides a more nuanced understanding of its role in adenoma detection and highlights the need for improved frameworks that link procedural complexity with quality outcomes.展开更多
The research explores the long-term connection between Greece’s agricultural output,with a focus on both crop and livestock production,and crucial environmental factors like water usage and energy consumption.Through...The research explores the long-term connection between Greece’s agricultural output,with a focus on both crop and livestock production,and crucial environmental factors like water usage and energy consumption.Through linear regression analysis,the study investigates how these factors affect agricultural value-added,providing insights into the sustainability and efficiency of Greece’s farming sector.The results show a significant(p<0.05)positive relationship between crop production and agricultural value-added,as well as the significant influence of water usage and energy consumption on the productivity of both crops and livestock.For livestock farming,the analysis revealed a weaker contribution to agricultural value-added at the national level,likely due to structural inefficiencies in the sector.While livestock production benefits significantly from water and energy inputs,it does not have as substantial an economic impact compared to crop production.This research contributes to the field of agricultural economics by offering a historical perspective on how resource management influences agricultural performance over time.It highlights the significance of sustainable practices,especially in areas like the periphery of Western Macedonia,which are shifting from conventional energy sources like lignite to renewable energy.The findings advocate for policies that promote water conservation,energy efficiency,and smart agriculture to enhance productivity and support regional development.展开更多
BACKGROUND Despite therapeutic benefits,discontinuation of tirzepatide is common in randomized controlled trials(RCTs)due to adverse events(AEs)and other causes.No previous systematic reviews have explored the reasons...BACKGROUND Despite therapeutic benefits,discontinuation of tirzepatide is common in randomized controlled trials(RCTs)due to adverse events(AEs)and other causes.No previous systematic reviews have explored the reasons for discontinuing tirzepatide in the RCTs.AIM To explore the reasons for permanent discontinuation of tirzepatide vs controls[placebo,insulin,and glucagon-like peptide-1 receptor agonists(GLP-1Ras)]in RCTs.METHODS Relevant RCTs were systematically searched using related terms through multiple databases such as MEDLINE(via PubMed),Scopus,Cochrane Central Register,and ClinicalTrials.gov from their inception until June 20,2024.RevMan web was used to conduct meta-analysis using random-effects models.Outcomes were presented as risk ratios(RR)with 95%confidence intervals(CI).RESULTS Seventeen RCTs(n=14645),mostly having low risks of bias,were analyzed.Compared to placebo,the risk of permanent discontinuation of the study drug was substantially lower with tirzepatide 10 mg(RR:0.69,95%CI:0.51-0.93,P=0.02)and similar with tirzepatide 5 mg(RR:0.74,95%CI:0.47-1.17,P=0.20)and 15 mg(RR:0.94,95%CI:0.68-1.31,P=0.71).Tirzepatide had identical discontinuation risks when compared to insulin at 5 mg(RR:0.96,95%CI:0.75-1.24,P=0.77)and 10 mg(RR:1.19,95%CI:0.77-1.82,P=0.44)doses,whereas such risk was higher with tirzepatide 15 mg than insulin(RR:1.31,95%CI:1.03-1.67,P=0.03).Compared to GLP-1RA,the permanent discontinuation risk was similar with tirzepatide 5 mg(RR:0.98,95%CI:0.70-1.37,P=0.90)but was higher with tirzepatide 10 mg(RR:1.40,95%CI:1.03-1.90,P=0.03)and 15 mg(RR:1.70,95%CI:1.27-2.27,P=0.0004).Tirzepatide,at all doses,had higher risks of AE-related discontinuation than insulin;such risks were only greater with higher doses of tirzepatide than with placebo or GLP-1RA.Discontinuation risk due to withdrawal by the study subjects was lower with tirzepatide than with placebo or insulin.Compared to the placebo,tirzepatide(all doses)conferred a lower risk of study drug discontinuation due to other causes not specifically mentioned.CONCLUSION The discontinuation risk is not higher in tirzepatide group than in the placebo arm.Many factors other than AEs led to drug discontinuation in the included RCTs.展开更多
BACKGROUND Colonic diverticular bleeding(CDB)is a leading cause of gastrointestinal blee-ding-related hospitalizations in Japan and is increasingly recognized as a signifi-cant burden in the United States.Identifying ...BACKGROUND Colonic diverticular bleeding(CDB)is a leading cause of gastrointestinal blee-ding-related hospitalizations in Japan and is increasingly recognized as a signifi-cant burden in the United States.Identifying the stigmata of a recent hemorrhage(SRH)during colonoscopy enables targeted hemostasis and reduces rebleeding.However,no benchmark exists for an appropriate observation duration,resulting in operator-dependent variation.Short observation periods may lead to missed SRH,whereas unnecessarily prolonged procedures,particularly in older patients,can increase patient burden and limit endoscopy unit availability.METHODS We retrospectively analyzed patients with acute hematochezia who underwent an initial colonoscopy between January 2017 and December 2024 at a Japanese tertiary hospital.The Observation time was measured from scope insertion to SRH detection(excluding therapeutic time)or withdrawal.The primary outcome,the“5%plateau time”,was defined as the point when the proportion of patients newly identified with SRH in each 5-minute interval consistently dropped below 5%.Computed tomography(CT)-based stratified analyses were performed by endoscopists who conducted≥10%of procedures.RESULTS Of the 1039 patients who underwent colonoscopy,845(mean age 77±11 years;64.5%male)were included.Nine board-certified endoscopists performed the procedures.SRH was detected in 286 patients(33.8%),with a median detection time of 19 minutes(interquartile range,12-28 minutes).The overall 5%plateau time was 40 minutes and varied according to the CT findings:40,35,and 30 minutes for no extravasation,right-sided extravasation,and left-sided extravasation,respectively.This time point corresponded to when 80%-90%of SRH cases were detected.De-spite variations in SRH detection rates and observation durations among endoscopists,the 5%plateau time was consistently approximately 40 minutes.CONCLUSION Although it varied according to the CT findings,the overall 5%plateau time was 40 minutes.This offers a practical benchmark for the minimum observation time without SRH detection.展开更多
This review examines the mechanisms of anxiety and depression in menopausal syndrome from an integrated physiological to psychological perspective.Fluctuations in estrogen and progesterone levels during menopause affe...This review examines the mechanisms of anxiety and depression in menopausal syndrome from an integrated physiological to psychological perspective.Fluctuations in estrogen and progesterone levels during menopause affect neurotransmitter systems(including serotonin,norepinephrine,and dopamine),hypothalamic-pituitary-adrenal axis function,inflammatory processes,and neurotrophic factor expression,collectively diminishing the resilience of emotional regulation neural circuits.Simultaneously,vasomotor symptoms(such as hot flashes and night sweats),sleep disruption,genetic susceptibility,and epigenetic modifications interact with mood disorders,while psychosocial factors(such as midlife stressors and role transitions)and cognitive factors(including negative schemas about aging,attentional bias toward threats,and difficulties in emotional regulation)further shape women’s experiences of menopausal changes.Clinical practice should adopt a biopsychosocial model,employing personalized multimodal approaches through hormone therapy,antidepressants,psychotherapy,and lifestyle adjustments,while future research should focus on developing biomarkers,utilizing advanced technologies,and developing targeted interventions to support women’s psychological wellbeing during menopause.展开更多
Using data from the 11th to 14th Five-Year Plan periods(2006-2025),this study applies a Difference-in-Differences(DID)approach to assess the impact of industrial policy withdrawal.Industries that have faced policy wit...Using data from the 11th to 14th Five-Year Plan periods(2006-2025),this study applies a Difference-in-Differences(DID)approach to assess the impact of industrial policy withdrawal.Industries that have faced policy withdrawal for over a decade are categorized as the treatment group,while consistently supported industries form the control group.The analysis examines how withdrawal affects firm total factor productivity(TFP)and investment behavior.The results show that policy withdrawal boosts firm TFP by reducing over-investment and improving the efficiency of R&D spending.This effect is particularly evident in industries with strong,competitive leading firms.Additionally,in regions with lower levels of marketization,timely policy withdrawal plays a key role in curbing over-investment.This study also highlights a dual effect of policy withdrawal:while it fosters corporate social responsibility,it may also encourage financial speculation.These findings suggest that the implementation of industrial policy should provide“timely assistance”over a limited timeframe rather than long-term support to well-established industries.As industries mature,policy support should be gradually reduced or phased out to avoid over-investment and enhance firm efficiency.展开更多
To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine in...To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine injection. The withdrawal syndromes were recorded and an HPLC-UV method was set up to quantify the plasma levels of morphine and morphine-3-glucuronide（M3G）. In the spontaneous withdrawal study, 97 rats were treated with progressive morphine for 28 d to develop physical dependence. The spontaneous withdrawal syndromes were recorded and plasma levels of morphine and M3G were determined after the last injection. No significant differences were observed in withdrawal syndrome of naloxone precipitating. More severe spontaneous withdrawal syndromes were produced by chronic morphine injection in male rats than in female rats（P0.05）. Higher maximum plasma concentration（Cmax） of morphine was measured in male rats than female rats, while female rats had higher Cmax of M3G than male rats in both acute and chronic morphine administration. Our results indicated that sex differences existed in withdrawal syndrome of morphine-dependent rats, and the pharmacokinetics of morphine showed sex difference by both acute and chronic administration. There might be a relationship between the severity of withdrawal syndrome and the plasma concentrations of morphine, M3G, and the ratio of morphine to M3G（M3G/MOR）.展开更多
Nb-16Si-24Ti-10Cr-2A1-2Hf alloy was directionally solidified with withdrawal rates of 1.2, 6, 18, 36 and 50 mrn/min and then heat treated at 1400, 1450 and 1500℃with withdrawal rate of 50 mm/min for 10 h. The effects...Nb-16Si-24Ti-10Cr-2A1-2Hf alloy was directionally solidified with withdrawal rates of 1.2, 6, 18, 36 and 50 mrn/min and then heat treated at 1400, 1450 and 1500℃with withdrawal rate of 50 mm/min for 10 h. The effects of withdrawal rate and heat treatment temperature on the microstructure were studied. The microstructure of directionally solidified alloy was composed of the primary NbsSi3, Nbss/NbsSi3 eutectic cells and Cr2Nb, which distribute paralleled to the growth direction. The microstructure becomes more refined with the increasing withdrawal rate, accompany with the evolution of eutectic cells morphology. After heat treatment, Nbss phase connects and forms a continuous matrix, and the Cr2Nb phase becomes smaller and distributes more dispersedly. After heat treatment at 1450 ℃ for 10 h, the alloy achieves balance between the optimization of microstructure and alleviation of solute segregation.展开更多
基金Under the auspices of National Science and Technology Support Projects of China(No.2014BAL01B01C)
文摘By considering numerical features, spatial variation, and spatial association, the spatial patterns of China's irrigation water withdrawals in 2001 and 2010 were explored at the regional, provincial, and prefectural scales. In addition, an overlay analysis was used to develop specific water-saving guidance for areas under different levels of water stress and with different degrees of irrigation water withdrawals. It was found that at the regional scale, irrigation water withdrawals were highest in the Middle-Lower Yangtze River region in both years, while at the provincial scale, the largest irrigation water withdrawals occurred in Xinjiang. During 2001–2010, the total of irrigation water withdrawals decreased; however, in the Northeast region, especially in Heilongjiang Province, it experienced a dramatic increase. The spatial variation was largest at the prefectural scale, with an apparent effect. The spatial association was globally negative at the provincial scale, and Xinjiang was the only significant high-low outlier. In contrast, the association displayed a significant positive relationship at the prefectural scale, and several clusters and outliers were detected. Finally, it was found that the water stress in the northern part of China worsened and water-saving irrigation techniques urgently need to be applied in the Northeast region, the Huang-Huai-Hai Plain region, and Gansu-Xinjiang region. This study verified that a multi-scale and aspect analysis of the spatial patterns of irrigation water withdrawals were essential and provided water-saving advice for different areas.
基金supported by the National Basic Research Program of China (No. 2010CB428804)the Public Welfare Industry Special Funds for Scientific Research from Ministry of Land and Resources of China (No. 201211079-4).
文摘The amount of water withdrawn by wells is one of the quantitative variables that can be applied to estimate groundwater resources and further evaluate the human influence on groundwater systems. The accuracy for the calculation of the amount of water withdrawal significantly influences the regional groundwater resource evaluation and management. However, the decentralized groundwater pumping, inefficient management, measurement errors and uncertainties have resulted in considerable errors in the groundwater withdrawal estimation. In this study, to improve the estimation of the groundwater withdrawal, an innovative approach was proposed using an inversion method based on a regional groundwater flow numerical model, and this method was then applied in the North China Plain. The principle of the method was matching the simulated water levels with the observation ones by adjusting the amount of groundwater withdrawal. In addition, uncertainty analysis of hydraulic conductivity and specific yield for the estimation of the groundwater withdrawal was conducted. By using the proposed inversion method, the estimated annual average groundwater withdrawal was approximately 24.92×10^9 m^3 in the North China Plain from 2002 to 2008. The inversion method also significantly improved the simulation results for both hydrograph and the flow field. Results of the uncertainty analysis showed that the hydraulic conductivity was more sensitive to the inversion results than the specific yield.
基金Under the auspices of the National Natural Science Foundation of China(No.71203200)the National Social Science Fund Project(No.20&ZD138)+1 种基金the National Science and Technology Platform Construction Project(No.2005DKA32300)the Major Research Projects of the Ministry of Education(No.16JJD770019)。
文摘With an increase in population and economic development,water withdrawals are close to or even exceed the amount of water available in many regions of the world.Modelling water withdrawals could help water planners improve the efficiency of water use,water resources allocation,and management in order to alleviate water crises.However,minimal information has been obtained on how water withdrawals have changed over space and time,especially on a regional or local scale.This research proposes a data-driven framework to help estimate county-level distribution of water withdrawals.Using this framework,spatial statistical methods are used to estimate water withdrawals for agricultural,industrial,and domestic purposes in the Huaihe River watershed in China for the period 1978–2018.Total water withdrawals were found to have more than doubled,from 292.55×10^(8)m^(3) in 1978 to 642.93×10^(8)m^(3) in 2009,and decreased to 602.63×10^(8)m^(3) in 2018.Agricultural water increased from 208.17×10^(8)m^(3) in 1978 to 435.80×10^(8)m^(3) in 2009 and decreased to 360.84×10^(8)m^(3) in 2018.Industrial and domestic water usage constantly increased throughout the 1978–2018 period.In 1978,industrial and domestic demands were 20.35×10^(8)m^(3) and 60.04×10^(8)m^(3),respectively,and up until 2018,the figures were 105.58×10^(8)m^(3) and 136.20×10^(8)m^(3).From a spatial distribution perspective,Moran’s I statistical results show that the total water withdrawal has significant spatial autocorrelation during 1978–2018.The overall trend was a gradual increase in 1978–2010 with withdrawal beginning to decline in 2010–2018.The results of Getis-Ord G_(i)^(*)statistical calculations showed spatially contiguous clusters of total water withdrawal in the Huaihe River watershed during1978–2010,and the spatial agglomeration weakened from 2010 to 2018.This study provides a data-driven framework for assessing water withdrawals to enable a deeper understanding of competing water use among economic sectors as well as water withdrawal modelled with proper data resource and method.
基金supported by 2024 The Basic Ability Improvement Project for Young and Middle-aged Teachers of Colleges and Universities in Guangxi(No.2024KY0165)2024 Guangxi Minzu University General Research Project(Humanities and Social Sciences Category,No.2024MDSKYB20)2022 Annual Teaching and Research Project of Shiyuan College of Nanning Normal University(No.2022JY13).
文摘Objectives:Non-suicidal self-injury(NSSI)represents a prominent and escalating concern within mental health,associated with considerable psychological and physical dangers.Peer victimization is identified as a significant predictor of NSSI behavior.Although prior research has explored the association between peer victimization and NSSI,the mechanisms underlying this relationship remain insufficiently understood.Utilizing social information processing theory frameworks,the present study seeks to examine the sequential mediating roles of a cognitive factor,future orientation,and a behavioral factor,social withdrawal,in middle school students.Methods:A cross-sectional survey was administered in China,involving 528 participants(261 females and 267 males;Meanage=13.71,standard deviation[SD]=0.93).Participants completed self-report measures assessing peer victimization via the Delaware Bullying Victimization Scale-Student Version,NSSI via the Adolescents Self-Harm Scale,future orientation via the Adolescent Future Orientation Questionnaire,and social withdrawal via the Social Withdrawal Questionnaire.Results:Findings indicated a significant positive correlation between peer victimization and NSSI(r=0.30,p<0.01).Additionally,future orientation and social withdrawal functioned as serial mediators,with an indirect effect of 0.01(95%CI:[0.01,0.02]),representing 2.70%of the total effect(𝛽=0.37,95%CI:[0.25,0.47]).Conclusions:The findings endorse a theoretical framework in which negative future outlook and social withdrawal are sequentially linked within the relationship between peer victimization and NSSI.Although the serial indirect effect observed is modest,it delineates a distinct associative pattern that characterizes adolescents subjected to victimization.These results carry practical significance for school-based intervention programs,indicating that targeting future perspectives and social connections may enhance strategies for preventing NSSI.
基金This study has been supported by the National Natural Science Foundation of China （Grant No. 71403270）, the Foundation of State Key Laboratory of Coal Resources and Safe Mining, China University of Mining ＆ Technology （Grant No. SKLCRSM14KFA03）, and the Specialized Research Fund for the Doctoral Program of Higher Education of China （Grant No. 20120023120002）.
文摘With ever increasing water demands and the continuous intensification of water scarcity arising from China＇s industrialization, the country is struggling to harmonize its industrial development and water supply. This paper presents a systems analysis of water with- drawals by Chinese industry and investigates demand- driven industrial water uses embodied in final demand and interregional trade based on a multi-regional input-output model. In 2007, the Electric Power, Steam, and Hot Water Production and Supply sector ranks first in direct industrial water withdrawal （DWW）, and Construction has the largest embodied industrial water use （EWU）. Investment, consumption, and exports contribute to 34.6%, 33.3%, and 30.6% of the national total EWU, respectively. Specifically, 58.0%, 51.1%, 48.6%, 43.3%, and 37.5% of the regional EWUs respectively in Guangdong, Shanghai, Zhejiang, Jiangsu, and Fujian are attributed to international exports. The total interregional import/export of embodied water is equivalent to about 40% of the national total DWW, of which 55.5% is associated with the DWWs of Electric Power, Steam, and Hot Water Production and Supply. Jiangsu is the biggest interregional exporter and deficit receiver of embodied water, in contrast to Guangdong as the biggest interregional importer and surplus receiver. Without implementing effective water- saving measures and adjusting industrial structures, the regional imbalance between water availability and water demand tends to intensify considering the water impact of domestic trade of industrial products. Steps taken to improve water use efficiency in production, and to enhance embodied water saving in consumption are both of great significance for supporting China＇s water policies.
基金Shenzhen Science and Technology Program(JSGG20220831092800001)。
文摘The microstructure of single crystal superalloy is relatively simple,consisting primarily ofγdendrites andγ/γ′eutectics.During the directional solidification process of Ni-based single crystal superalloys,withdrawal rate is a critical parameter affecting the spatial distribution ofγ/γ′eutectic along gravity direction.The results show that theγ/γ′eutectic fraction of the upper platform surface is always higher than that of the lower one,regardless of withdrawal rate.As the withdrawal rate decreases,there is a significant increase inγ/γ′eutectic fraction on the upper surface,while it decreases on the lower surface.The upward accumulation ofγ/γ′eutectic becomes more severe as the withdrawal rate decreases.It is also found that the percentage of Al+Ta is positively correlated with theγ/γ′eutectic fraction.Thermo-solute convection of Al and Ta solutes in the solidification front is the prime reason for the non-uniform distribution of eutectic.The non-uniform distribution ofγ/γ′eutectic cannot be eliminated even after subsequent solution heat treatment,resulting in excess eutectic on the upper surface and thus leading to the scrapping of the blade.
基金Supported by the Instituto de Salud Carlos III,No.PI22/00910.
文摘BACKGROUND Glucocorticoids(GC)are the cornerstone in the treatment of severe alcoholassociated hepatitis(SAH)but may be associated with adverse events.CASE SUMMARY We report a prospective series of patients with SAH who were treated with GC and developed de novo arthropathy within 2 weeks of GC cessation.Five patients were included in this series,three of whom were women.All patients underwent ultrasound evaluation and were referred to the Rheumatology Clinics.Final diagnoses were:Arthralgia associated with GC cessation(n=3),polymyalgia rheumatica(n=1)and psoriatic arthritis(n=1).Joint soreness was the main symptom,whereas arthritis occurred rarely.Patients with arthralgia associated with GC cessation required longer regimes of GC and tapering strategies but remained free of symptoms and specific treatment in the long term.CONCLUSION De novo arthropathy may occur following GC for SAH.Close monitoring and tapering regimes are advised.
基金Supported by the R+D Project funded by the Spanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033 and by FEDER,EU,No.PID2021-122987OA-I00.
文摘BACKGROUND Psychotic disorders are characterized by both positive symptoms(hallucinations,delusions)and negative symptoms(emotional blunting,anhedonia)that impair daily functioning.While antipsychotic drugs and psychological interventions are effective when addressing positive symptoms,treatment of negative symptoms remains an ongoing challenge.Mindfulness-based interventions(MBIs)have been shown to reduce negative psychotic symptoms.However,as negative psychotic symptoms are assessed as a sole entity rather than a sum of manifestations,the effect of MBIs remains unclear.AIM To examine the effects of MBI in addition to integrated rehabilitation treatment(IRT)for people experiencing psychosis on each of the negative psychotic symptoms.METHODS A randomized controlled clinical trial with preintervention and postintervention measures was designed.The main outcome variable was negative psychotic symptoms assessed through the seven subscales of the Spanish version of the positive and negative syndrome scale.Data were analyzed using a repeated measures analysis of variance and reliable change index calculation.RESULTS There were no statistical differences between groups at the preintervention assessment.Statistically significant differences were found after MBI for the time in emotional withdrawal(F=37.75,P<0.001,η2=0.437)and social withdrawal(F=37.75,P<0.001,η2=0.437).CONCLUSION MBI added to IRT reduced the lack of interest and involvement with affective commitment to daily life activities,and interest and engagement in social activities increased.These negative psychotic symptoms were not improved by IRT alone.
基金Supported by the Young and Middle-Aged Talents Program of Wuxi Health Commission,No.BJ2020011Cohort Research Program of Wuxi Medical Center,Nanjing Medical University,No.WMCC202314Wuxi People’s Hospital 2024“Wild Goose Array Talent”Reserve Discipline Leader,No.2024-YZ-HBDTR-YC-2024.
文摘BACKGROUND Adenoma detection rate(ADR),a key colonoscopy quality metric,varies with patient demographics and procedural factors.AIM To identify independent predictors of≥25%ADR,develop a risk model,and propose withdrawal durations based on different insertion times.METHODS We retrospectively analyzed 830 cases using logistic regression and identified four key factors,validated in a prospective cohort of 5699 patients.Their importance was confirmed using random forest(RF),extreme gradient boosting(XGBoost)and light gradient boosting machine(LightGBM).Attempts to determine targetachieving withdrawal time by grouping cases based on insertion time and Cox regression were inconclusive.Using the 5699-case dataset,we developed a predictive model combining support vector machine(SVM)with XGBoost.We built a Shiny app using this model for clinical application.RESULTS Multivariate logistic regression identified age[odds ratio(OR)=1.05;95%confidence interval(CI):1.03-1.08;P<0.001],male(OR=1.79;95%CI:1.32-2.41;P=0.005),higher endoscopist experience(OR=1.79;95%CI:1.20-2.68;P=0.005),and longer withdrawal time(P<0.001)as independent risk factors for colorectal adenoma.A nomogram demonstrated strong discrimination[area under the curve(AUC)=0.720],with robust calibration and decision-curve performance.Feature importance via RF,XGBoost,and LightGBM confirmed key predictors.A hybrid model combining SVM regression for withdrawal-time estimation and XGBoost classification achieved stable results,with XGBoost reporting AUCs of 0.640 in training and 0.610 in testing,and similar validation outcomes.Deployed via a Shiny app for clinical use.However,model discrimination was modest(AUC:0.61-0.64),suggesting that clinical utility requires further refinement.CONCLUSION A hybrid SVM-XGBoost model using four key endoscopic factors was independently validated and is available as a Shiny app,delivering real-time decision support to streamline endoscopy and enhance clinical outcomes.
文摘BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To evaluate the outcomes of 5-ASA withdrawal due to non-adherence in UC patients while in remission on monotherapy.METHODS Adult patients with UC who were followed up between July 2019 and April 2025 were screened.Patients in remission receiving 5-ASA monotherapy who experienced treatment withdrawal due to non-adherence were included in this study.RESULTS Among 880 patients with UC,30(3.4%)had 5-ASA withdrawal due to nonadherence while in remission on monotherapy.Twelve patients(40%)had disease relapse after a median of 20 months.The rate of patients in remission was 89%in the first year,decreasing to 73%in the second year,and to 64%in the third year.There were no significant differences between patients with and without relapse in terms of demographics,disease extent,remission duration before 5-ASA withdrawal,previous medications,steroid dependence,5-ASA formulation,baseline inflammatory markers,or partial and endoscopic Mayo scores.Most patients(75%)who experienced relapse were successfully treated with 5-ASA monotherapy,while one-fourth of them required corticosteroids.No patients required biologic agents,hospitalization,or surgical intervention.CONCLUSION Intermittent therapy may be safe and feasible for UC patients,especially those in long-term remission,with treatment interruption up to one year considered acceptable.
文摘This invited commentary discusses the recent study by Atay et al,which investigated relapse rates following the spontaneous withdrawal of maintenance 5-aminosalicylates in ulcerative colitis.The discussion focuses,in this patient setting,on the possible reasons that might prompt clinicians to pursue such exit strategies,and on the importance of exercising caution in these decisions,given the extremely narrow subsets of patients for whom international guidelines allow any degree of leeway.
文摘Existing literature indicates that prolonged insertion time is associated with procedural complexity and may influence adenoma detection.Xu et al recently reported that longer insertion time correlates with lower adenoma detection,but this effect can be mitigated by sufficient withdrawal duration.Insertion time should not be regarded merely as a numeric variable but rather as a multidimensional marker of technical difficulty.Integrating the insertion-to-withdrawal ratio with composite indicators such as looping or bowel preparation quality may enhance predictive models of colonoscopy performance.Conceptualizing insertion time in this way provides a more nuanced understanding of its role in adenoma detection and highlights the need for improved frameworks that link procedural complexity with quality outcomes.
文摘The research explores the long-term connection between Greece’s agricultural output,with a focus on both crop and livestock production,and crucial environmental factors like water usage and energy consumption.Through linear regression analysis,the study investigates how these factors affect agricultural value-added,providing insights into the sustainability and efficiency of Greece’s farming sector.The results show a significant(p<0.05)positive relationship between crop production and agricultural value-added,as well as the significant influence of water usage and energy consumption on the productivity of both crops and livestock.For livestock farming,the analysis revealed a weaker contribution to agricultural value-added at the national level,likely due to structural inefficiencies in the sector.While livestock production benefits significantly from water and energy inputs,it does not have as substantial an economic impact compared to crop production.This research contributes to the field of agricultural economics by offering a historical perspective on how resource management influences agricultural performance over time.It highlights the significance of sustainable practices,especially in areas like the periphery of Western Macedonia,which are shifting from conventional energy sources like lignite to renewable energy.The findings advocate for policies that promote water conservation,energy efficiency,and smart agriculture to enhance productivity and support regional development.
文摘BACKGROUND Despite therapeutic benefits,discontinuation of tirzepatide is common in randomized controlled trials(RCTs)due to adverse events(AEs)and other causes.No previous systematic reviews have explored the reasons for discontinuing tirzepatide in the RCTs.AIM To explore the reasons for permanent discontinuation of tirzepatide vs controls[placebo,insulin,and glucagon-like peptide-1 receptor agonists(GLP-1Ras)]in RCTs.METHODS Relevant RCTs were systematically searched using related terms through multiple databases such as MEDLINE(via PubMed),Scopus,Cochrane Central Register,and ClinicalTrials.gov from their inception until June 20,2024.RevMan web was used to conduct meta-analysis using random-effects models.Outcomes were presented as risk ratios(RR)with 95%confidence intervals(CI).RESULTS Seventeen RCTs(n=14645),mostly having low risks of bias,were analyzed.Compared to placebo,the risk of permanent discontinuation of the study drug was substantially lower with tirzepatide 10 mg(RR:0.69,95%CI:0.51-0.93,P=0.02)and similar with tirzepatide 5 mg(RR:0.74,95%CI:0.47-1.17,P=0.20)and 15 mg(RR:0.94,95%CI:0.68-1.31,P=0.71).Tirzepatide had identical discontinuation risks when compared to insulin at 5 mg(RR:0.96,95%CI:0.75-1.24,P=0.77)and 10 mg(RR:1.19,95%CI:0.77-1.82,P=0.44)doses,whereas such risk was higher with tirzepatide 15 mg than insulin(RR:1.31,95%CI:1.03-1.67,P=0.03).Compared to GLP-1RA,the permanent discontinuation risk was similar with tirzepatide 5 mg(RR:0.98,95%CI:0.70-1.37,P=0.90)but was higher with tirzepatide 10 mg(RR:1.40,95%CI:1.03-1.90,P=0.03)and 15 mg(RR:1.70,95%CI:1.27-2.27,P=0.0004).Tirzepatide,at all doses,had higher risks of AE-related discontinuation than insulin;such risks were only greater with higher doses of tirzepatide than with placebo or GLP-1RA.Discontinuation risk due to withdrawal by the study subjects was lower with tirzepatide than with placebo or insulin.Compared to the placebo,tirzepatide(all doses)conferred a lower risk of study drug discontinuation due to other causes not specifically mentioned.CONCLUSION The discontinuation risk is not higher in tirzepatide group than in the placebo arm.Many factors other than AEs led to drug discontinuation in the included RCTs.
文摘BACKGROUND Colonic diverticular bleeding(CDB)is a leading cause of gastrointestinal blee-ding-related hospitalizations in Japan and is increasingly recognized as a signifi-cant burden in the United States.Identifying the stigmata of a recent hemorrhage(SRH)during colonoscopy enables targeted hemostasis and reduces rebleeding.However,no benchmark exists for an appropriate observation duration,resulting in operator-dependent variation.Short observation periods may lead to missed SRH,whereas unnecessarily prolonged procedures,particularly in older patients,can increase patient burden and limit endoscopy unit availability.METHODS We retrospectively analyzed patients with acute hematochezia who underwent an initial colonoscopy between January 2017 and December 2024 at a Japanese tertiary hospital.The Observation time was measured from scope insertion to SRH detection(excluding therapeutic time)or withdrawal.The primary outcome,the“5%plateau time”,was defined as the point when the proportion of patients newly identified with SRH in each 5-minute interval consistently dropped below 5%.Computed tomography(CT)-based stratified analyses were performed by endoscopists who conducted≥10%of procedures.RESULTS Of the 1039 patients who underwent colonoscopy,845(mean age 77±11 years;64.5%male)were included.Nine board-certified endoscopists performed the procedures.SRH was detected in 286 patients(33.8%),with a median detection time of 19 minutes(interquartile range,12-28 minutes).The overall 5%plateau time was 40 minutes and varied according to the CT findings:40,35,and 30 minutes for no extravasation,right-sided extravasation,and left-sided extravasation,respectively.This time point corresponded to when 80%-90%of SRH cases were detected.De-spite variations in SRH detection rates and observation durations among endoscopists,the 5%plateau time was consistently approximately 40 minutes.CONCLUSION Although it varied according to the CT findings,the overall 5%plateau time was 40 minutes.This offers a practical benchmark for the minimum observation time without SRH detection.
基金Supported by Zhejiang Provincial Medical and Health Science and Technology Program,No.2025KY196.
文摘This review examines the mechanisms of anxiety and depression in menopausal syndrome from an integrated physiological to psychological perspective.Fluctuations in estrogen and progesterone levels during menopause affect neurotransmitter systems(including serotonin,norepinephrine,and dopamine),hypothalamic-pituitary-adrenal axis function,inflammatory processes,and neurotrophic factor expression,collectively diminishing the resilience of emotional regulation neural circuits.Simultaneously,vasomotor symptoms(such as hot flashes and night sweats),sleep disruption,genetic susceptibility,and epigenetic modifications interact with mood disorders,while psychosocial factors(such as midlife stressors and role transitions)and cognitive factors(including negative schemas about aging,attentional bias toward threats,and difficulties in emotional regulation)further shape women’s experiences of menopausal changes.Clinical practice should adopt a biopsychosocial model,employing personalized multimodal approaches through hormone therapy,antidepressants,psychotherapy,and lifestyle adjustments,while future research should focus on developing biomarkers,utilizing advanced technologies,and developing targeted interventions to support women’s psychological wellbeing during menopause.
基金supported by the Major Project of the Beijing Social Science Fund“Research on Constructing a New Development Pattern and the Coordinated Development of the Beijing-Tianjin-Hebei Region”(20ZDA31).
文摘Using data from the 11th to 14th Five-Year Plan periods(2006-2025),this study applies a Difference-in-Differences(DID)approach to assess the impact of industrial policy withdrawal.Industries that have faced policy withdrawal for over a decade are categorized as the treatment group,while consistently supported industries form the control group.The analysis examines how withdrawal affects firm total factor productivity(TFP)and investment behavior.The results show that policy withdrawal boosts firm TFP by reducing over-investment and improving the efficiency of R&D spending.This effect is particularly evident in industries with strong,competitive leading firms.Additionally,in regions with lower levels of marketization,timely policy withdrawal plays a key role in curbing over-investment.This study also highlights a dual effect of policy withdrawal:while it fosters corporate social responsibility,it may also encourage financial speculation.These findings suggest that the implementation of industrial policy should provide“timely assistance”over a limited timeframe rather than long-term support to well-established industries.As industries mature,policy support should be gradually reduced or phased out to avoid over-investment and enhance firm efficiency.
基金National Science and Technology Support Program of China(Grant No.2008BAI49B01)the National Basic Research Program of China(Grant No.2009CB522000)
文摘To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine injection. The withdrawal syndromes were recorded and an HPLC-UV method was set up to quantify the plasma levels of morphine and morphine-3-glucuronide（M3G）. In the spontaneous withdrawal study, 97 rats were treated with progressive morphine for 28 d to develop physical dependence. The spontaneous withdrawal syndromes were recorded and plasma levels of morphine and M3G were determined after the last injection. No significant differences were observed in withdrawal syndrome of naloxone precipitating. More severe spontaneous withdrawal syndromes were produced by chronic morphine injection in male rats than in female rats（P0.05）. Higher maximum plasma concentration（Cmax） of morphine was measured in male rats than female rats, while female rats had higher Cmax of M3G than male rats in both acute and chronic morphine administration. Our results indicated that sex differences existed in withdrawal syndrome of morphine-dependent rats, and the pharmacokinetics of morphine showed sex difference by both acute and chronic administration. There might be a relationship between the severity of withdrawal syndrome and the plasma concentrations of morphine, M3G, and the ratio of morphine to M3G（M3G/MOR）.
基金Project(51101005)supported by the National Natural Science Foundation of China
文摘Nb-16Si-24Ti-10Cr-2A1-2Hf alloy was directionally solidified with withdrawal rates of 1.2, 6, 18, 36 and 50 mrn/min and then heat treated at 1400, 1450 and 1500℃with withdrawal rate of 50 mm/min for 10 h. The effects of withdrawal rate and heat treatment temperature on the microstructure were studied. The microstructure of directionally solidified alloy was composed of the primary NbsSi3, Nbss/NbsSi3 eutectic cells and Cr2Nb, which distribute paralleled to the growth direction. The microstructure becomes more refined with the increasing withdrawal rate, accompany with the evolution of eutectic cells morphology. After heat treatment, Nbss phase connects and forms a continuous matrix, and the Cr2Nb phase becomes smaller and distributes more dispersedly. After heat treatment at 1450 ℃ for 10 h, the alloy achieves balance between the optimization of microstructure and alleviation of solute segregation.
