The clustering evaluation can be used to scientifically classify the objects to be evaluated according to the information aggregation of various evaluation rules. In grey weighted clustering evaluation, the index clus...The clustering evaluation can be used to scientifically classify the objects to be evaluated according to the information aggregation of various evaluation rules. In grey weighted clustering evaluation, the index clustering rule relies on the construction of the whitenization weight function, while the existing construction method of the linear function lacks the construction mechanism analysis and validity explanation. A normative construction principle is put forward by analyzing the construction mechanism of the function. Through proving the normative principle of the function,the basic modal function(BMF) is proposed and characterized by different function forms. Then, a new type of the whitenization weight function and its grey clustering evaluation model algorithm are given by studying the mechanism and nature of the construction of different forms of the function. Finally, the comparative study for self-innovation capability of defense science and technology industry(DSTI) is taken as an example. The results show that the different construction ways of the function have an effect on the clustering result. The proposed construction mechanism can better explain the index clustering rules and evaluation effectiveness,which will perfect the theoretical system of grey clustering evaluation and be applied to practice effectively.展开更多
Establish an efficacy evaluation method for foundation products in vivo and vitro.The hiding power,whiteness,waterproof and anti-sweat effect were evaluated in vitro test,where CR ratio,Individual Type Angle (ITA°...Establish an efficacy evaluation method for foundation products in vivo and vitro.The hiding power,whiteness,waterproof and anti-sweat effect were evaluated in vitro test,where CR ratio,Individual Type Angle (ITA°) and chromatic aberration (E) were measured as evaluation indicators by standard black/white cardboard,artificial leather and artificial sweat.In clinical assessment,the anti-stain,waterproof,anti-sweat effect of the foundation products were evaluated through the ΔE change,before and after the treatment of products by staining,wetting,sweating in forearm skin.There were significant differences in CR ratio of different types of samples on standard black and white cardboards (P<0.05),ITA° of artificial leather has a significant increase after treatment (P<0.05),?E﹤1.5 in black cloth after dipping test,while ΔE﹤1.5 in leather after water and artificial sweat treatment.Clinical assessment showed that ?E ﹤50%,which had no significant difference in human skin color,before and after the test (P>0.05).The change trend of efficacy evaluation in vitro test was basically consistent with that of visual evaluation and clinical assessment,indicated that the efficacy evaluation methods of foundation products in vivo and vitro are intuitive,quantifiable,and can be used to evaluate the efficacy of foundation products.展开更多
The delicate balance of oral microbiota is frequently disrupted by exogenous discoloration and biofilm formation,thus requiring integrated antibacterial and whitening strategies.Conventional peroxide treatments often ...The delicate balance of oral microbiota is frequently disrupted by exogenous discoloration and biofilm formation,thus requiring integrated antibacterial and whitening strategies.Conventional peroxide treatments often damage the integrity of tooth enamel,while nanocatalysts pose cytotoxicity risks.In this work,we designed a biocompatible polydopamine-engineered barium titanate nanocomposite(BTO@PDA_(x)).By optimizing polydopamine(PDA)shell thickness,BTO@PDA_(0.5) exhibited superior excellent piezoelectric catalytic activity.Under ultrasound irradiation,PDA enhanced reactive oxygen species(ROS)generation by promoting charge carrier separation at the BTO interface,thereby accelerating chromogen degradation kinetics.Antibacterial assays and tooth whitening studies confirmed that BTO@PDA_(0.5) could effectively inhibit microorganisms and degrade pigments with extremely low cytotoxicity.This study designed a highly biocompatible organic-inorganic composite piezoelectric material,providing a new strategy for oral health care.展开更多
Herein,a new method was developed for efficient and lasting fluorescent whitening cotton fabric by synthesizing and using a vinyl-containing fluorescent whitening agent to covalently grafting onto fiber surfaces with ...Herein,a new method was developed for efficient and lasting fluorescent whitening cotton fabric by synthesizing and using a vinyl-containing fluorescent whitening agent to covalently grafting onto fiber surfaces with the assistance of electron beam irradiation.The results from FT-IR spectroscopic,X-ray photoelectron spectroscopic,and energy dispersive spectrometric analyses showed that the fluorescent whitening agent was successfully anchored on cotton fiber via radiation-induced grafting copolymerization.The optimized whiteness value at 110.81(that of raw cotton fabric,74.50)was achieved using just 0.3 wt% fluorescent whitening agent.Notably,the whiteness value of the treated cotton fabric remained 110+even after 100 equivalent home-washing cycles,substantiating its excellent washing durability.Skin stimulation experiments on rabbits showed that the primary stimulation index of all experimental groups was 0 and no abnormal clinical symptoms were found in all tested rabbits,demonstrating the outstanding skin safety.Furthermore,energy generated by irradiation grafting technology was much lower than that of traditional processes and water consumption greatly reduced.Even the effluent from this process completely met the discharge standard of industrial wastewater without any treatment.This study explores a new method for textile finishing via electron beam irradiation,providing a green and sustainable perspective for the textile industry.展开更多
Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuo...Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuous light exposure.This study aimed to investigate the morphological and functional alterations in BAT under continuous light conditions and to identify traditional Chinese medicine compounds capable of reversing these changes.Methods:A metabolic disorder model was established by subjecting mice to continuous light exposure for 5 weeks.During this period,body weight,food intake,and body fat percentage were monitored.Serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were measured to assess lipid metabolism.Histological changes in BAT were examined using H&E staining.The expression of the thermogenic marker uncoupling protein 1(UCP1)in BAT was determined by RT-qPCR and Western blot to evaluate thermogenic function.RNA sequencing(RNA-seq)was employed to identify differentially expressed genes(DEGs)involved in BAT whitening induced by prolonged continuous light exposure.DEGs were analyzed using the connectivity map(CMap)database to identify potential preventive and therapeutic compounds.The therapeutic efficacy of the selected compounds was subsequently evaluated using the above indicators,and key pathways were validated through western blot analysis.Results:After 5 weeks of continuous light exposure,mice exhibited increased body fat percentage and serum levels of TG,impaired mitochondrial function,reduced thermogenic capacity,and whitening of BAT.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analyses indicated that BAT whitening was primarily associated with the adenosine 5'-monophosphate-activated protein kinase(AMPK)signaling pathway,fatty acid metabolism,and circadian rhythm.Ten hub genes identified using Cytoscape were mainly related to AMPK signaling and heat shock proteins.In vivo experiments showed that cordycepin significantly attenuated the increase in body fat percentage caused by prolonged light exposure.This effect was mediated by activation of the AMPK/PGC-1α/UCP1 signaling pathway,which restored the multilocular morphology and thermogenic function of BAT.Conclusion:Cordycepin mitigates continuous light-induced BAT whitening and metabolic disturbances by activating the AMPK signaling pathway.展开更多
In order to explore the application of saussurea involucrata extract in skin care products,the skin care efficacy and safety of saussurea involucrata extract were verified through hyaluronidase inhibition test,zebrafi...In order to explore the application of saussurea involucrata extract in skin care products,the skin care efficacy and safety of saussurea involucrata extract were verified through hyaluronidase inhibition test,zebrafish repair efficacy evaluation,human immortalized epidermal cell anti-photodamage test,in vitro anti-glycation test,fibroblast proliferation test,zebrafish whitening test,human clinical trial and closed patch test.The results showed that 10%of the extract passed the closed patch test,indicating that it was mild and non-irritating.Saussurea involucrata extract can inhibit hyaluronidase activity and promote the production of blocking protein,indicating that it has soothing and repairing effect at the same time.The extract can significantly inhibit the glycosylation reaction,and can effectively resist the damage of blue light and ultraviolet,and has certain anti-glycosylation and antiphotodamage effects.The extract can promote the proliferation of 3T3 cells,and has certain firming and anti-wrinkle effect.The extract can effectively inhibit the melanin production of zebrafish and has certain whitening effect.The human clinical trial comparative test confirmed that the whitening effect of 10%saussurea involucrata extract is equivalent to 7%ascorbic acid.展开更多
Because the physiological characteristics and melanin regulation mechanism of zebrafish are highly similar with those of humans,it is of high reference value to use zebrafish model in the evaluation of cosmetic whiten...Because the physiological characteristics and melanin regulation mechanism of zebrafish are highly similar with those of humans,it is of high reference value to use zebrafish model in the evaluation of cosmetic whitening efficacy.In this study,zebrafish embryos are used as biological models to evaluate the whitening efficacy of six kinds of cosmetics raw materials,such as antioxidant,preservative and essence,and the formula of facial cleanser and facial mask products,and the limitations of the zebrafish melanin production grayscale detection method in practical application are discussed.The results show that the selection of different types of components can also reduce the production of melanin and show whitening effect.It can be seen that the gray scale method of melanin production in zebrafish is suitable for the evaluation of the efficacy of raw materials.In practical application,due to the complexity of the formula,the toxic effects of different types of ingredients may interfere with the melanin generation of zebrafish,affecting the judgment and evaluation of whitening efficacy.For the detection of whitening efficacy of products,a comprehensive evaluation system should be built together with other methods to accurately evaluate the whitening efficacy.展开更多
Background Thermogenic adipose tissue,both beige and brown,experiences whitening as animals are exposed to warmth and age,but the potential mechanisms are not fully understood.In this study,we employed singlenucleus R...Background Thermogenic adipose tissue,both beige and brown,experiences whitening as animals are exposed to warmth and age,but the potential mechanisms are not fully understood.In this study,we employed singlenucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes.Results Our histological studies and bulk transcriptome gene expression analysis confirmed that both perirenal and omental adipose tissues(pAT and oAT)exhibited progressive whitening in goats.Compared to the classic brown adipocytes in mice,goat thermogenic adipocytes were more closely related in gene expression patterns to human beige adipocytes,which was also confirmed by adipocyte type-and lineage-specific marker expression analysis.Furthermore,trajectory analysis revealed beige-and white-like adipocytes deriving from a common origin,coexisting and undergoing the transdifferentiation.In addition,differences in gene expression profiles and cell communication patterns(e.g.,FGF and CALCR signaling)between oAT and pAT suggested a lower thermogenic capacity of oAT than that of pAT.Conclusions We constructed a cell atlas of goat pAT and oAT and descripted the characteristics of thermogenic adipocytes during whitening progression.Altogether,our results make a significant contribution to the molecular and cellular mechanisms behind the whitening of thermogenic adipocytes,and providing new insights into obesity prevention in humans and cold adaptation in animals.展开更多
Signal to noise ratio （SNR） and resolution are two important but contradictory characteristics used to evaluate the quality of seismic data. For relatively preserving SNR while enhancing resolution, the signal purit...Signal to noise ratio （SNR） and resolution are two important but contradictory characteristics used to evaluate the quality of seismic data. For relatively preserving SNR while enhancing resolution, the signal purity spectrum is introduced, estimated, and used to define the desired output amplitude spectrum after deconvolution. Since a real reflectivity series is blue rather than white, the effects of white reflectivity hypothesis on wavelets are experimentally analyzed and color compensation is applied after spectrum whitening. Experiments on real seismic data indicate that the cascade of the two processing stages can improve the ability of seismic data to delineate the geological details.展开更多
The kernel of interval grey number is most likely the real number,which can be used to represent whitenization value of interval grey number.A novel method for calculating kernel of interval grey number is constructed...The kernel of interval grey number is most likely the real number,which can be used to represent whitenization value of interval grey number.A novel method for calculating kernel of interval grey number is constructed based on the geometric barycenter of whitenization weight function in the two-dimensional coordinate plane,and the calculation of kernel is converted to the calculation of barycenter in geometric figures.The method fully considers the effect of all information contained in whitenization weight function on the calculation result of kernel,and is the extension and perfection of the existing methods in the scope of application.展开更多
Deconvolution is widely used to increase the resolution of seismic data.To compare the resolution ability of conventional spectrum whitening deconvolution to thin layers with that of welldriven deconvolution,a complex...Deconvolution is widely used to increase the resolution of seismic data.To compare the resolution ability of conventional spectrum whitening deconvolution to thin layers with that of welldriven deconvolution,a complex sedimentary geological model was designed,and then the simulated seismic data were processed respectively by each of the two methods.The amplitude spectrum of seismic data was almost white after spectrum whitening,but the wavelet resolution was low.The amplitude spectrum after well-driven deconvolution deviated from white spectrum,but the wavelet resolution was high.Further analysis showed that if an actual reflectivity series could not well satisfy the hypothesis of white spectrum,spectrum whitening deconvolution had a potential risk of wavelet distortion,which might lead to a pitfall in high resolution seismic data interpretation.On the other hand,the wavelet after well-driven deconvolution had higher resolution both in the time and frequency domains.It is favorable for high resolution seismic interpretation and reservoir prediction.展开更多
Data processing of small samples is an important and valuable research problem in the electronic equipment test. Because it is difficult and complex to determine the probability distribution of small samples, it is di...Data processing of small samples is an important and valuable research problem in the electronic equipment test. Because it is difficult and complex to determine the probability distribution of small samples, it is difficult to use the traditional probability theory to process the samples and assess the degree of uncertainty. Using the grey relational theory and the norm theory, the grey distance information approach, which is based on the grey distance information quantity of a sample and the average grey distance information quantity of the samples, is proposed in this article. The definitions of the grey distance information quantity of a sample and the average grey distance information quantity of the samples, with their characteristics and algorithms, are introduced. The correlative problems, including the algorithm of estimated value, the standard deviation, and the acceptance and rejection criteria of the samples and estimated results, are also proposed. Moreover, the information whitening ratio is introduced to select the weight algorithm and to compare the different samples. Several examples are given to demonstrate the application of the proposed approach. The examples show that the proposed approach, which has no demand for the probability distribution of small samples, is feasible and effective.展开更多
The global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023,at around a 7%annual growth rate.The cosmetics industry is emerging as one of the fastest-growing industries ...The global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023,at around a 7%annual growth rate.The cosmetics industry is emerging as one of the fastest-growing industries of the past decade.Data shows that the Chinese cosmetics market was US$60 billion in 2021.It is expected to be the world’s number one consumer cosmetics market by 2050,with a size of approximately US$450 billion.The influence of social media and the internet has raised awareness of the risks associated with the usage of many chemicals in cosmetics and the health benefits of natural products derived from plants and other natural resources.As a result,the cosmetic industry is now paying more attention to natural products.The present review focus on the possible applications of natural products from various biological sources in skin care cosmetics,including topical care products,fragrances,moisturizers,UV protective,and anti-wrinkle products.In addition,the mechanisms of targets for evaluation of active ingredients in cosmetics and the possible benefits of these bioactive compounds in rejuvenation and health,and their potential role in cosmetics are also discussed.展开更多
The growing demand for brilliant smile and tooth whitening has led to the increasing significance of tooth whitening methods.However,the development of tooth whitening materials with high efficiency and safety has bee...The growing demand for brilliant smile and tooth whitening has led to the increasing significance of tooth whitening methods.However,the development of tooth whitening materials with high efficiency and safety has been considered to be an urgent challenge.Here,we report a novel tooth whitening strategy,which overcomes the limitation of conventional methods,shows excellent tooth whitening efficiency and safety,and even exhibits outstanding antibacterial activity.Inspired by stomata and chloroplasts in green leaves,we have developed an integrated two-phase free radical hydrogel(TP-GEL),which integrates solid-phase and liquid-phase free radical functional components fabricated by cold plasma technology.TP-GEL demonstrated safe and ultrafast tooth-whitening effect with or without visible light,which can be more significant than that of 30% H_(2)O_(2),the commonly whitening material in dental clinical practice.More importantly,we also avoid the damage to enamel,such as microhardness,roughness,surface morphology.Benefiting from free radicals,much higher antibacterial properties than commercial products(Chlorhexidine)was obtained.This research provides fundamental design criteria for the development of dual functional oral health care materials with advanced tooth whitening and antibacterial activity.展开更多
Speckle filtering is an indispensable pre-processing step for applications of polarimetric synthetic aperture radar （POLSAR）, such as terrain classification, target detection, etc. As one of the most typical methods...Speckle filtering is an indispensable pre-processing step for applications of polarimetric synthetic aperture radar （POLSAR）, such as terrain classification, target detection, etc. As one of the most typical methods, the polarimetric whitening filter （PWF） can be used to produce a minimum-speckle image by combining the complex elements of the scattering matrix, but polarimetric information is lost after the filtering process. A polarimetric filter based on subspaze decomposition which was proposed by Cu et al specializes in retrieving principle scattering characteristics, but the corresponding mean value of an image after filtering is not kept well. A new filter is proposed for improving the disadvantage based on subspace decomposition. Under the constraint that a weighted combination of the polarimetric SAR images equals to the output of the PWF, the Euclidean distance between an unfiltered parameter vector and a signal space vector is minimized so that noises can be reduced. It is also shown that the proposed method is equivalent to the subspace filter in the case of no constraint. Experimental results with the NASA/JPL airborne polarimetric SAR data demonstrate the effectiveness of the proposed method.展开更多
In this paper, the backdrop and significance of the research of germ-remaining rice whitener firstly were expatiated. Then, the study progress in China and overseas was summarized. Lastly, the research prospect of thi...In this paper, the backdrop and significance of the research of germ-remaining rice whitener firstly were expatiated. Then, the study progress in China and overseas was summarized. Lastly, the research prospect of this kind of whitener in China was analyzed. It is hoped that it can coach the design of germ-remaining rice whitener.展开更多
A sensitive method for simultaneous determination of six phenolic whitening agents, including arbutin, phenol, resorcinol, hydroquinone, kojic acid, and salicylic acid in cosmetics has been developed using micellar el...A sensitive method for simultaneous determination of six phenolic whitening agents, including arbutin, phenol, resorcinol, hydroquinone, kojic acid, and salicylic acid in cosmetics has been developed using micellar electrokinetic capillary chromatography with amperometric detection （MECC-AD）. Effects of several factors, such as the pH value and concentration of running buffer, potential applied to the working electrode, separation voltage, and injection time were investigated to obtain optimum conditions for separation and detection. With a 75 cm long fused-silica capillary tube, well-defined separation of six phenolic compounds was achieved in 10 mmol/L SDS/40 mmol/L H3BO3-Na2B407 running buffer （pH 9.0）. Good linear relationship was obtained for each analyte over three orders of magnitude with correlation coefficients （r2） between 0.9985 and 0.9994, and the detection limit （S/N = 3） ranged from 0.04 p^g/mL to 0.45 p^g/mL. The proposed method has been successfully applied for the determination of phenolic whitening agents in real cosmetic samples with satisfactory results, providing an alternative monitoring method for cosmetics safety regulation.展开更多
Hydroquinone is potentially carcinogenic and is known to be a skin and respiratory irritant.Hydroquinone is carcinogenic it has been banned in some countries because of fears of a cancer risk[1,2].Animal studies have ...Hydroquinone is potentially carcinogenic and is known to be a skin and respiratory irritant.Hydroquinone is carcinogenic it has been banned in some countries because of fears of a cancer risk[1,2].Animal studies have shown that topically applied retinoic acid can be photocarcinogenic[3].The aim of this study was qualitative and quantitative determination of hydroquinone and retinoic acid contents in facial whitening creams by colour reaction tests,FT-IR after TLC separation and HPLC.展开更多
基金supported by the National Natural Science Foundation of China(71671090)the Aeronautical Science Foundation of China(2016ZG52068)+1 种基金the Liberal Arts and Social Sciences Foundation of the Ministry of Education(MOE)in China(15YJCZH189)the Qinglan Project for Excellent Youth or Middle-aged Academic Leaders in Jiangsu Province
文摘The clustering evaluation can be used to scientifically classify the objects to be evaluated according to the information aggregation of various evaluation rules. In grey weighted clustering evaluation, the index clustering rule relies on the construction of the whitenization weight function, while the existing construction method of the linear function lacks the construction mechanism analysis and validity explanation. A normative construction principle is put forward by analyzing the construction mechanism of the function. Through proving the normative principle of the function,the basic modal function(BMF) is proposed and characterized by different function forms. Then, a new type of the whitenization weight function and its grey clustering evaluation model algorithm are given by studying the mechanism and nature of the construction of different forms of the function. Finally, the comparative study for self-innovation capability of defense science and technology industry(DSTI) is taken as an example. The results show that the different construction ways of the function have an effect on the clustering result. The proposed construction mechanism can better explain the index clustering rules and evaluation effectiveness,which will perfect the theoretical system of grey clustering evaluation and be applied to practice effectively.
文摘Establish an efficacy evaluation method for foundation products in vivo and vitro.The hiding power,whiteness,waterproof and anti-sweat effect were evaluated in vitro test,where CR ratio,Individual Type Angle (ITA°) and chromatic aberration (E) were measured as evaluation indicators by standard black/white cardboard,artificial leather and artificial sweat.In clinical assessment,the anti-stain,waterproof,anti-sweat effect of the foundation products were evaluated through the ΔE change,before and after the treatment of products by staining,wetting,sweating in forearm skin.There were significant differences in CR ratio of different types of samples on standard black and white cardboards (P<0.05),ITA° of artificial leather has a significant increase after treatment (P<0.05),?E﹤1.5 in black cloth after dipping test,while ΔE﹤1.5 in leather after water and artificial sweat treatment.Clinical assessment showed that ?E ﹤50%,which had no significant difference in human skin color,before and after the test (P>0.05).The change trend of efficacy evaluation in vitro test was basically consistent with that of visual evaluation and clinical assessment,indicated that the efficacy evaluation methods of foundation products in vivo and vitro are intuitive,quantifiable,and can be used to evaluate the efficacy of foundation products.
基金supported by the National Key Research and Development Program of China(No.2022YFB3205602)the National Natural Science Foundation of China(Nos.52372174,and 32401198)+1 种基金Beijing Nova Programme Interdisciplinary Cooperation Project(No.20250484970)the Carbon Neutrality Research Institute Fund(No.CNIF20230204).
文摘The delicate balance of oral microbiota is frequently disrupted by exogenous discoloration and biofilm formation,thus requiring integrated antibacterial and whitening strategies.Conventional peroxide treatments often damage the integrity of tooth enamel,while nanocatalysts pose cytotoxicity risks.In this work,we designed a biocompatible polydopamine-engineered barium titanate nanocomposite(BTO@PDA_(x)).By optimizing polydopamine(PDA)shell thickness,BTO@PDA_(0.5) exhibited superior excellent piezoelectric catalytic activity.Under ultrasound irradiation,PDA enhanced reactive oxygen species(ROS)generation by promoting charge carrier separation at the BTO interface,thereby accelerating chromogen degradation kinetics.Antibacterial assays and tooth whitening studies confirmed that BTO@PDA_(0.5) could effectively inhibit microorganisms and degrade pigments with extremely low cytotoxicity.This study designed a highly biocompatible organic-inorganic composite piezoelectric material,providing a new strategy for oral health care.
基金supported by the National Natural Science Foundation of China(Nos.12075153 and 11875313)CNNC Key Laboratory on Uranium Extraction from Seawater(No.KLUES202205).
文摘Herein,a new method was developed for efficient and lasting fluorescent whitening cotton fabric by synthesizing and using a vinyl-containing fluorescent whitening agent to covalently grafting onto fiber surfaces with the assistance of electron beam irradiation.The results from FT-IR spectroscopic,X-ray photoelectron spectroscopic,and energy dispersive spectrometric analyses showed that the fluorescent whitening agent was successfully anchored on cotton fiber via radiation-induced grafting copolymerization.The optimized whiteness value at 110.81(that of raw cotton fabric,74.50)was achieved using just 0.3 wt% fluorescent whitening agent.Notably,the whiteness value of the treated cotton fabric remained 110+even after 100 equivalent home-washing cycles,substantiating its excellent washing durability.Skin stimulation experiments on rabbits showed that the primary stimulation index of all experimental groups was 0 and no abnormal clinical symptoms were found in all tested rabbits,demonstrating the outstanding skin safety.Furthermore,energy generated by irradiation grafting technology was much lower than that of traditional processes and water consumption greatly reduced.Even the effluent from this process completely met the discharge standard of industrial wastewater without any treatment.This study explores a new method for textile finishing via electron beam irradiation,providing a green and sustainable perspective for the textile industry.
文摘Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuous light exposure.This study aimed to investigate the morphological and functional alterations in BAT under continuous light conditions and to identify traditional Chinese medicine compounds capable of reversing these changes.Methods:A metabolic disorder model was established by subjecting mice to continuous light exposure for 5 weeks.During this period,body weight,food intake,and body fat percentage were monitored.Serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were measured to assess lipid metabolism.Histological changes in BAT were examined using H&E staining.The expression of the thermogenic marker uncoupling protein 1(UCP1)in BAT was determined by RT-qPCR and Western blot to evaluate thermogenic function.RNA sequencing(RNA-seq)was employed to identify differentially expressed genes(DEGs)involved in BAT whitening induced by prolonged continuous light exposure.DEGs were analyzed using the connectivity map(CMap)database to identify potential preventive and therapeutic compounds.The therapeutic efficacy of the selected compounds was subsequently evaluated using the above indicators,and key pathways were validated through western blot analysis.Results:After 5 weeks of continuous light exposure,mice exhibited increased body fat percentage and serum levels of TG,impaired mitochondrial function,reduced thermogenic capacity,and whitening of BAT.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analyses indicated that BAT whitening was primarily associated with the adenosine 5'-monophosphate-activated protein kinase(AMPK)signaling pathway,fatty acid metabolism,and circadian rhythm.Ten hub genes identified using Cytoscape were mainly related to AMPK signaling and heat shock proteins.In vivo experiments showed that cordycepin significantly attenuated the increase in body fat percentage caused by prolonged light exposure.This effect was mediated by activation of the AMPK/PGC-1α/UCP1 signaling pathway,which restored the multilocular morphology and thermogenic function of BAT.Conclusion:Cordycepin mitigates continuous light-induced BAT whitening and metabolic disturbances by activating the AMPK signaling pathway.
文摘In order to explore the application of saussurea involucrata extract in skin care products,the skin care efficacy and safety of saussurea involucrata extract were verified through hyaluronidase inhibition test,zebrafish repair efficacy evaluation,human immortalized epidermal cell anti-photodamage test,in vitro anti-glycation test,fibroblast proliferation test,zebrafish whitening test,human clinical trial and closed patch test.The results showed that 10%of the extract passed the closed patch test,indicating that it was mild and non-irritating.Saussurea involucrata extract can inhibit hyaluronidase activity and promote the production of blocking protein,indicating that it has soothing and repairing effect at the same time.The extract can significantly inhibit the glycosylation reaction,and can effectively resist the damage of blue light and ultraviolet,and has certain anti-glycosylation and antiphotodamage effects.The extract can promote the proliferation of 3T3 cells,and has certain firming and anti-wrinkle effect.The extract can effectively inhibit the melanin production of zebrafish and has certain whitening effect.The human clinical trial comparative test confirmed that the whitening effect of 10%saussurea involucrata extract is equivalent to 7%ascorbic acid.
文摘Because the physiological characteristics and melanin regulation mechanism of zebrafish are highly similar with those of humans,it is of high reference value to use zebrafish model in the evaluation of cosmetic whitening efficacy.In this study,zebrafish embryos are used as biological models to evaluate the whitening efficacy of six kinds of cosmetics raw materials,such as antioxidant,preservative and essence,and the formula of facial cleanser and facial mask products,and the limitations of the zebrafish melanin production grayscale detection method in practical application are discussed.The results show that the selection of different types of components can also reduce the production of melanin and show whitening effect.It can be seen that the gray scale method of melanin production in zebrafish is suitable for the evaluation of the efficacy of raw materials.In practical application,due to the complexity of the formula,the toxic effects of different types of ingredients may interfere with the melanin generation of zebrafish,affecting the judgment and evaluation of whitening efficacy.For the detection of whitening efficacy of products,a comprehensive evaluation system should be built together with other methods to accurately evaluate the whitening efficacy.
基金supported by the National Key Research and Development Programme of China(grant number 2021YFF1001000)the National Natural Science Foundation of China(grant number 32170627)+1 种基金the Postdoctoral Innovative Talents Support Program of China(grant number BX20200282)the Natural Science Foundation of Sichuan Province(grant number 23NSFSC1804).
文摘Background Thermogenic adipose tissue,both beige and brown,experiences whitening as animals are exposed to warmth and age,but the potential mechanisms are not fully understood.In this study,we employed singlenucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes.Results Our histological studies and bulk transcriptome gene expression analysis confirmed that both perirenal and omental adipose tissues(pAT and oAT)exhibited progressive whitening in goats.Compared to the classic brown adipocytes in mice,goat thermogenic adipocytes were more closely related in gene expression patterns to human beige adipocytes,which was also confirmed by adipocyte type-and lineage-specific marker expression analysis.Furthermore,trajectory analysis revealed beige-and white-like adipocytes deriving from a common origin,coexisting and undergoing the transdifferentiation.In addition,differences in gene expression profiles and cell communication patterns(e.g.,FGF and CALCR signaling)between oAT and pAT suggested a lower thermogenic capacity of oAT than that of pAT.Conclusions We constructed a cell atlas of goat pAT and oAT and descripted the characteristics of thermogenic adipocytes during whitening progression.Altogether,our results make a significant contribution to the molecular and cellular mechanisms behind the whitening of thermogenic adipocytes,and providing new insights into obesity prevention in humans and cold adaptation in animals.
基金supported by the National Natural Science Foundation of China(Grant No.41174117)PetroChina Innovation Foundation(Grant No.2010D-5006-0301)
文摘Signal to noise ratio （SNR） and resolution are two important but contradictory characteristics used to evaluate the quality of seismic data. For relatively preserving SNR while enhancing resolution, the signal purity spectrum is introduced, estimated, and used to define the desired output amplitude spectrum after deconvolution. Since a real reflectivity series is blue rather than white, the effects of white reflectivity hypothesis on wavelets are experimentally analyzed and color compensation is applied after spectrum whitening. Experiments on real seismic data indicate that the cascade of the two processing stages can improve the ability of seismic data to delineate the geological details.
基金Supported by the National Natural Science Foundation of China(71271226,70971064,71101159)the Humanities and Social Science Foundation of Ministry of Education(11YJC630273,12YJC630140)+4 种基金the Program for Chongqing Innovation Team in University(KJTD201313)the Science and Technology Research Projects of Chongqing Education Commission(KJ120706)the Open Foundation of Chongqing Key Laboratory of Electronic Commerce and Supply Chain System(2012ECSC0101)the Special Fund of Chongqing Key Laboratory of Electronic Commerce and Supply Chain System(2012ECSC0217)the Chongqing City Board of Education Science and Technology Research Projects(1202010)
文摘The kernel of interval grey number is most likely the real number,which can be used to represent whitenization value of interval grey number.A novel method for calculating kernel of interval grey number is constructed based on the geometric barycenter of whitenization weight function in the two-dimensional coordinate plane,and the calculation of kernel is converted to the calculation of barycenter in geometric figures.The method fully considers the effect of all information contained in whitenization weight function on the calculation result of kernel,and is the extension and perfection of the existing methods in the scope of application.
基金supported by National 973 Key Basic Research Development Program(No.2007CB209608)National 863 High Technology Research Development Program(No.2007AA06Z218)
文摘Deconvolution is widely used to increase the resolution of seismic data.To compare the resolution ability of conventional spectrum whitening deconvolution to thin layers with that of welldriven deconvolution,a complex sedimentary geological model was designed,and then the simulated seismic data were processed respectively by each of the two methods.The amplitude spectrum of seismic data was almost white after spectrum whitening,but the wavelet resolution was low.The amplitude spectrum after well-driven deconvolution deviated from white spectrum,but the wavelet resolution was high.Further analysis showed that if an actual reflectivity series could not well satisfy the hypothesis of white spectrum,spectrum whitening deconvolution had a potential risk of wavelet distortion,which might lead to a pitfall in high resolution seismic data interpretation.On the other hand,the wavelet after well-driven deconvolution had higher resolution both in the time and frequency domains.It is favorable for high resolution seismic interpretation and reservoir prediction.
文摘Data processing of small samples is an important and valuable research problem in the electronic equipment test. Because it is difficult and complex to determine the probability distribution of small samples, it is difficult to use the traditional probability theory to process the samples and assess the degree of uncertainty. Using the grey relational theory and the norm theory, the grey distance information approach, which is based on the grey distance information quantity of a sample and the average grey distance information quantity of the samples, is proposed in this article. The definitions of the grey distance information quantity of a sample and the average grey distance information quantity of the samples, with their characteristics and algorithms, are introduced. The correlative problems, including the algorithm of estimated value, the standard deviation, and the acceptance and rejection criteria of the samples and estimated results, are also proposed. Moreover, the information whitening ratio is introduced to select the weight algorithm and to compare the different samples. Several examples are given to demonstrate the application of the proposed approach. The examples show that the proposed approach, which has no demand for the probability distribution of small samples, is feasible and effective.
基金funding from the National Natural Science Foundation of China (Grant Numbers 21961142008,22177138).
文摘The global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023,at around a 7%annual growth rate.The cosmetics industry is emerging as one of the fastest-growing industries of the past decade.Data shows that the Chinese cosmetics market was US$60 billion in 2021.It is expected to be the world’s number one consumer cosmetics market by 2050,with a size of approximately US$450 billion.The influence of social media and the internet has raised awareness of the risks associated with the usage of many chemicals in cosmetics and the health benefits of natural products derived from plants and other natural resources.As a result,the cosmetic industry is now paying more attention to natural products.The present review focus on the possible applications of natural products from various biological sources in skin care cosmetics,including topical care products,fragrances,moisturizers,UV protective,and anti-wrinkle products.In addition,the mechanisms of targets for evaluation of active ingredients in cosmetics and the possible benefits of these bioactive compounds in rejuvenation and health,and their potential role in cosmetics are also discussed.
基金financially supported by the Peking University Biomed-X Foundation,China。
文摘The growing demand for brilliant smile and tooth whitening has led to the increasing significance of tooth whitening methods.However,the development of tooth whitening materials with high efficiency and safety has been considered to be an urgent challenge.Here,we report a novel tooth whitening strategy,which overcomes the limitation of conventional methods,shows excellent tooth whitening efficiency and safety,and even exhibits outstanding antibacterial activity.Inspired by stomata and chloroplasts in green leaves,we have developed an integrated two-phase free radical hydrogel(TP-GEL),which integrates solid-phase and liquid-phase free radical functional components fabricated by cold plasma technology.TP-GEL demonstrated safe and ultrafast tooth-whitening effect with or without visible light,which can be more significant than that of 30% H_(2)O_(2),the commonly whitening material in dental clinical practice.More importantly,we also avoid the damage to enamel,such as microhardness,roughness,surface morphology.Benefiting from free radicals,much higher antibacterial properties than commercial products(Chlorhexidine)was obtained.This research provides fundamental design criteria for the development of dual functional oral health care materials with advanced tooth whitening and antibacterial activity.
基金supported by the National Natural Science Foundation of China (40571099)the Research Fund for the Doctoral Program of Higher Education of China.
文摘Speckle filtering is an indispensable pre-processing step for applications of polarimetric synthetic aperture radar （POLSAR）, such as terrain classification, target detection, etc. As one of the most typical methods, the polarimetric whitening filter （PWF） can be used to produce a minimum-speckle image by combining the complex elements of the scattering matrix, but polarimetric information is lost after the filtering process. A polarimetric filter based on subspaze decomposition which was proposed by Cu et al specializes in retrieving principle scattering characteristics, but the corresponding mean value of an image after filtering is not kept well. A new filter is proposed for improving the disadvantage based on subspace decomposition. Under the constraint that a weighted combination of the polarimetric SAR images equals to the output of the PWF, the Euclidean distance between an unfiltered parameter vector and a signal space vector is minimized so that noises can be reduced. It is also shown that the proposed method is equivalent to the subspace filter in the case of no constraint. Experimental results with the NASA/JPL airborne polarimetric SAR data demonstrate the effectiveness of the proposed method.
文摘In this paper, the backdrop and significance of the research of germ-remaining rice whitener firstly were expatiated. Then, the study progress in China and overseas was summarized. Lastly, the research prospect of this kind of whitener in China was analyzed. It is hoped that it can coach the design of germ-remaining rice whitener.
基金supported by the Natural Science Foundation of China(No.21205042)the Special Funds for the Development of Major Scientific Instruments and Equipment(No. 2011YQ15007205)
文摘A sensitive method for simultaneous determination of six phenolic whitening agents, including arbutin, phenol, resorcinol, hydroquinone, kojic acid, and salicylic acid in cosmetics has been developed using micellar electrokinetic capillary chromatography with amperometric detection （MECC-AD）. Effects of several factors, such as the pH value and concentration of running buffer, potential applied to the working electrode, separation voltage, and injection time were investigated to obtain optimum conditions for separation and detection. With a 75 cm long fused-silica capillary tube, well-defined separation of six phenolic compounds was achieved in 10 mmol/L SDS/40 mmol/L H3BO3-Na2B407 running buffer （pH 9.0）. Good linear relationship was obtained for each analyte over three orders of magnitude with correlation coefficients （r2） between 0.9985 and 0.9994, and the detection limit （S/N = 3） ranged from 0.04 p^g/mL to 0.45 p^g/mL. The proposed method has been successfully applied for the determination of phenolic whitening agents in real cosmetic samples with satisfactory results, providing an alternative monitoring method for cosmetics safety regulation.
文摘Hydroquinone is potentially carcinogenic and is known to be a skin and respiratory irritant.Hydroquinone is carcinogenic it has been banned in some countries because of fears of a cancer risk[1,2].Animal studies have shown that topically applied retinoic acid can be photocarcinogenic[3].The aim of this study was qualitative and quantitative determination of hydroquinone and retinoic acid contents in facial whitening creams by colour reaction tests,FT-IR after TLC separation and HPLC.
