Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly releva...Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their first- degree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands （19 patients and 41 unaffected parents） and two unrelated groups of normal controls （24 controls matched with patients and 26 controls matched with relatives）. The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global efficiency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic psychopathology.We also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that （1） the global efficiency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and （2） genetic vulnerability to schizophrenia may influence the anatomical organization of an individual＇s brain networks.展开更多
目的 探索生理性衰老受试者中大脑体积的变化以及全脑功能网络的特征性改变。方法 纳入正常中老年组志愿者组(50~80岁)42名(HC group 1,HCg1),中青年组(20~40岁)健康志愿者33名(HC group 2,HCg2)。通过基于体素的形态学分析,对T_(1)序...目的 探索生理性衰老受试者中大脑体积的变化以及全脑功能网络的特征性改变。方法 纳入正常中老年组志愿者组(50~80岁)42名(HC group 1,HCg1),中青年组(20~40岁)健康志愿者33名(HC group 2,HCg2)。通过基于体素的形态学分析,对T_(1)序列分割出的全脑皮质及白质体积进行组间比较。之后,对两组的静息态脑功能成像进行基于网络的分析,比较全脑功能网络与脑区的连接特征并对比功能连接均值。结果 在灰质体积分析中,HCg1较HCg2在双侧颞叶、额叶、小脑出现了显著的灰质体积减小(P<0.05,FDR多重比较校正P<0.01),白质体积的缩小发生在胼胝体体部及双侧穹窿脚。全脑网络连接均值比较中,HCg1表现出了更高的平均功能连接值(P<0.05,FDR多重比较校正P<0.01)。结论 不同年龄段皮质及白质形态出现多个区域的萎缩,提示衰老过程伴随着多种局部基础生理机能的降低。但通过全脑功能网络的连接特征说明,大脑前部代偿性的功能连接增强,可能是脑功能的强健性及脑储备能力出现的原因之一。展开更多
基金supported by grants from the National Basic Research Program of China (2011CB707805)the National Natural Science Foundation of China (81370032, 91232305, 81361120395, and 91432304)the International Science & Technology Cooperation Program of China (2010DFB30820)
文摘Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their first- degree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands （19 patients and 41 unaffected parents） and two unrelated groups of normal controls （24 controls matched with patients and 26 controls matched with relatives）. The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global efficiency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic psychopathology.We also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that （1） the global efficiency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and （2） genetic vulnerability to schizophrenia may influence the anatomical organization of an individual＇s brain networks.
文摘目的 探索生理性衰老受试者中大脑体积的变化以及全脑功能网络的特征性改变。方法 纳入正常中老年组志愿者组(50~80岁)42名(HC group 1,HCg1),中青年组(20~40岁)健康志愿者33名(HC group 2,HCg2)。通过基于体素的形态学分析,对T_(1)序列分割出的全脑皮质及白质体积进行组间比较。之后,对两组的静息态脑功能成像进行基于网络的分析,比较全脑功能网络与脑区的连接特征并对比功能连接均值。结果 在灰质体积分析中,HCg1较HCg2在双侧颞叶、额叶、小脑出现了显著的灰质体积减小(P<0.05,FDR多重比较校正P<0.01),白质体积的缩小发生在胼胝体体部及双侧穹窿脚。全脑网络连接均值比较中,HCg1表现出了更高的平均功能连接值(P<0.05,FDR多重比较校正P<0.01)。结论 不同年龄段皮质及白质形态出现多个区域的萎缩,提示衰老过程伴随着多种局部基础生理机能的降低。但通过全脑功能网络的连接特征说明,大脑前部代偿性的功能连接增强,可能是脑功能的强健性及脑储备能力出现的原因之一。
