A team of researchers from the Department of Biomedical Engineering at Stanford University has announced the clinical validation of a flexible wearable biosensor that enables real-time monitoring of key metabolic biom...A team of researchers from the Department of Biomedical Engineering at Stanford University has announced the clinical validation of a flexible wearable biosensor that enables real-time monitoring of key metabolic biomarkers.The device,which integrates microfluidic technology,electrochemical sensing,and biocompatible materials,represents a significant advancement in point-of-care diagnostics and personalized medicine.展开更多
Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility,multi-functionality,and physiochemical pr...Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility,multi-functionality,and physiochemical properties similar to those of body tissues.However,the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process difficult.To overcome this issue,hydrophilic conductive polydopamine(PDA)-doped polypyrrole(PPy)nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel networks.This tech-nique creates a complete conductive network and allows visible light to pass through.The strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency,but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection,as evidenced by the experimental data.展开更多
Diabetes mellitus represents a major global health issue,driving the need for noninvasive alternatives to traditional blood glucose monitoring methods.Recent advancements in wearable technology have introduced skin-in...Diabetes mellitus represents a major global health issue,driving the need for noninvasive alternatives to traditional blood glucose monitoring methods.Recent advancements in wearable technology have introduced skin-interfaced biosensors capable of analyzing sweat and skin biomarkers,providing innovative solutions for diabetes diagnosis and monitoring.This review comprehensively discusses the current developments in noninvasive wearable biosensors,emphasizing simultaneous detection of biochemical biomarkers(such as glucose,cortisol,lactate,branched-chain amino acids,and cytokines)and physiological signals(including heart rate,blood pressure,and sweat rate)for accurate,personalized diabetes management.We explore innovations in multimodal sensor design,materials science,biorecognition elements,and integration techniques,highlighting the importance of advanced data analytics,artificial intelligence-driven predictive algorithms,and closed-loop therapeutic systems.Additionally,the review addresses ongoing challenges in biomarker validation,sensor stability,user compliance,data privacy,and regulatory considerations.A holistic,multimodal approach enabled by these next-generation wearable biosensors holds significant potential for improving patient outcomes and facilitating proactive healthcare interventions in diabetes management.展开更多
Wearable biosensors have received great interest as patient-friendly diagnostic technologies because of their high flexibility and conformability.The growing research and utilization of novel materials in designing we...Wearable biosensors have received great interest as patient-friendly diagnostic technologies because of their high flexibility and conformability.The growing research and utilization of novel materials in designing wearable biosensors have accelerated the development of point-of-care sensing platforms and implantable biomedical devices in human health care.Among numerous potential materials,conjugated polymers(CPs)are emerging as ideal choices for constructing high-performance wearable biosensors because of their outstanding conductive and mechanical properties.Recently,CPs have been extensively incorporated into various wearable biosensors to monitor a range of target biomolecules.However,fabricating highly reliable CP-based wearable biosensors for practical applications remains a significant challenge,necessitating novel developmental strategies for enhancing the viability of such biosensors.Accordingly,this review aims to provide consolidated scientific evidence by summarizing and evaluating recent studies focused on designing and fabricating CP-based wearable biosensors,thereby facilitating future research.Emphasizing the superior properties and benefits of CPs,this review aims to clarify their potential applicability within this field.Furthermore,the fundamentals and main components of CP-based wearable biosensors and their sensing mechanisms are discussed in detail.The recent advancements in CP nanostructures and hybridizations for improved sensing performance,along with recent innovations in next-generation wearable biosensors are highlighted.CPbased wearable biosensors have been—and will continue to be—an ideal platform for developing effective and user-friendly diagnostic technologies for human health monitoring.展开更多
Continuous drug monitoring is a promising alternative to current therapeutic drug monitoring strategies and has a strong potential to reshape our understanding of pharmacokinetic variability and to improve individuali...Continuous drug monitoring is a promising alternative to current therapeutic drug monitoring strategies and has a strong potential to reshape our understanding of pharmacokinetic variability and to improve individualised therapy.This review highlights recent advances in biosensing technologies that support continuous drug monitoring in real time.We focus primarily on aptamer-based biosensors,wearable and implantable devices.Emphasis is given to the approaches employed in constructing biosensors.We pay attention to sensors’biocompatibility,calibration performance,long-term characteristics stability and measurement quality.Last,we discuss the current challenges and issues to be addressed in continuous drug monitoring to make it a promising,future tool for individualised therapy.The ongoing efforts are expected to result in fully integrated implantable drug biosensing technology.Thus,we may anticipate an era of advanced healthcare in which wearable and implantable biochips will automatically adjust drug dosing in response to patient health conditions,thus enabling the management of diseases and enhancing individualised therapy.展开更多
In recent years, analyses of sweat have become more popular since it doesn't require invasive sampling procedures. Although blood still remains the golden standards in clinical, analyses of other common body fluid...In recent years, analyses of sweat have become more popular since it doesn't require invasive sampling procedures. Although blood still remains the golden standards in clinical, analyses of other common body fluids,such as sweat, have become increasingly important. Because the compositions of sweat and blood are osmotically related, the content of certain metabolites in sweat can directly reflect the disease. Sweat detection can be used as an alternative to blood detection and allows continuous monitoring. Increased development of wearable sensors makes it possible for continuous sweat detection. Here, this paper gave a review about the sweat detection methods, such as fluorescence sensing, electrochemical sensing and colorimetric sensing. The advantages and disadvantages of each method and their developing trend in sweat detection were summarized. Then, for the problem of continuous sweat sampling, three methods(capillary force, hydrogel osmotic pump, evaporationdriven micropump) were introduced through different structures of microfluidic chip, and the level of sweat collection and transport achieved by related research was demonstrated. This review aims to provide guidance for future research in sweat detection and stimulate further interest in continuous monitoring of sweat using microfluidic chip.展开更多
In recent years,wearable electrochemical biosensors have received increasing attention,benefiting from the growing demand for continuous monitoring for personalized medicine and point-of-care medical assistance.Incorp...In recent years,wearable electrochemical biosensors have received increasing attention,benefiting from the growing demand for continuous monitoring for personalized medicine and point-of-care medical assistance.Incorporating electrochemical biosensing and corresponding power supply into everyday textiles could be a promising strategy for next-generation non-invasive and comfort interaction mode with healthcare.This review starts with the manufacturing and structural design of electrochemical biosensing textiles and discusses a series of wearable electrochemical biosensing textiles monitoring various biomarkers(e.g.,pH,electrolytes,metabolite,and cytokines)at the molecular level.The fiber-shaped or textile-based solar cells and aqueous batteries as corresponding energy harvesting and storage devices are further introduced as a complete power supply for electrochemical biosensing textiles.Finally,we discuss the challenges and prospects relating to sensing textile systems from wearability,durability,washability,sample collection and analysis,and clinical validation.展开更多
Continuous cortisol monitoring(CCM)is essential for stress management,providing physiological insights into psychology and physical health.However,promising platform for CCM urges the design of effective biorecognitio...Continuous cortisol monitoring(CCM)is essential for stress management,providing physiological insights into psychology and physical health.However,promising platform for CCM urges the design of effective biorecognition moieties and the skin integration of sophisticated functions.Herein,we present a computationally-assisted wearable system for CCM(CWSCCM)that leverages cutting-edge interdisciplinary technologies of in-situ regenerative molecularly imprinted polymers(MIP),signal amplifier organic electrochemical transistor(OECT),iontophoresis-based sweat induction,and microfluidic sweat sampling.The highly integrated system incorporated with OECT biosensor enables in-situ MIP regeneration,and offers continuous approach for cortisol monitoring,with an ultra-low limit of detection of0.36 nmol/L.We validated the capability of the CWSCCM for long-term cortisol circadian rhythm monitoring in human participants,which shows superior sensitivity,selectivity,and continuous monitoring capabilities.In conclusion,we demonstrated how computational chemistry and OECT technology can extend the capabilities of current wearable CCM,which could potentially advance closed-loop therapeutics applications.展开更多
Wearable sweat sensors that enable non-invasive sampling,efficient and rapid detection,and real-time monitoring capabilities have become an integral and critical component of human health management,with the potential...Wearable sweat sensors that enable non-invasive sampling,efficient and rapid detection,and real-time monitoring capabilities have become an integral and critical component of human health management,with the potential to provide meaningful clinical information related to physiologic diseases in the healthcare field.Here,a flexible nanoplasmonic paper-based sensor based on surface-enhanced Raman scattering(SERS)was developed,in which silver nanoparticles were loaded in the cellulose paper to enhance the Raman signals of targets via the generation of SERS“hotspots.”By incorporating the filter paper channel with a natural core absorbing liquid,the multifunctional chip is formed,which integrates the collection,transmission,and detection of trace sweat.This paperbased chip is soft and stretchable,and fits perfectly onto the human skin surface without causing any damage or irritation.Combined with a hand-held Raman spectrometer,quantitative detection of multiple sweat components can be achieved with the limit of detection of 17 and 1μmol/L for uric acid and glucose,respectively,and the measurable range is 4–7.5 for pH,enabling wearable and in-situ optical sensing for sweat markers under the condition of human physiology and pathology,within only 5 min for uric acid and glucose detection.This wearable biosensor would provide,to our knowledge,a new way for continuously monitoring the health status by collection and analysis of multiple components in human sweat,contributing to point-of-care testing and personalized medicine applications.展开更多
Wearable biosensors,which aim at providing continuous,real-time physiological information via monitoring and screening biomarkers in human body,are receiving increasing attention among various fields including dis-eas...Wearable biosensors,which aim at providing continuous,real-time physiological information via monitoring and screening biomarkers in human body,are receiving increasing attention among various fields including dis-ease treatment,diagnosis and self-health management.The ongoing development in this realm starves for the exploration of fully-integrated,non-invasive devices.In this paper,we review the latest achievements with break-through significance on the wearable biosensors.We start with the classification of different types of wearable electronic devices and analyze their characteristics and application values.Subsequently,we introduce a fully-integrated microneedle-based sensor and provide an in-depth look at its structure,subcomponents and in vivo performances.Finally,we put forward critical commentaries and clarify the direction of future researches.展开更多
Wearable and implantable biosensors have emerged as transformative tools in modern healthcare,enabling real-time monitoring of physiological parameters and continuous tracking of biomarkers such as glucose,lactate,and...Wearable and implantable biosensors have emerged as transformative tools in modern healthcare,enabling real-time monitoring of physiological parameters and continuous tracking of biomarkers such as glucose,lactate,and hormones,thereby facilitating early disease detection,personalized treatment plans,and proactive health management[1].The integration of such sensors into daily life holds the promise of revolutionizing patient care by providing immediate feedback and reducing the need for invasive procedures[2].展开更多
文摘A team of researchers from the Department of Biomedical Engineering at Stanford University has announced the clinical validation of a flexible wearable biosensor that enables real-time monitoring of key metabolic biomarkers.The device,which integrates microfluidic technology,electrochemical sensing,and biocompatible materials,represents a significant advancement in point-of-care diagnostics and personalized medicine.
基金the Beijing Municipal Natural Science Foundation (No. 7212206)the National Natural Science Foundation of China (Nos. 21774132, 22072155, 22002170, 21571025, and 21601025)Project of Young Science and Technology Star of Dalian (No. 2017RQ156).
文摘Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility,multi-functionality,and physiochemical properties similar to those of body tissues.However,the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process difficult.To overcome this issue,hydrophilic conductive polydopamine(PDA)-doped polypyrrole(PPy)nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel networks.This tech-nique creates a complete conductive network and allows visible light to pass through.The strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency,but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection,as evidenced by the experimental data.
文摘Diabetes mellitus represents a major global health issue,driving the need for noninvasive alternatives to traditional blood glucose monitoring methods.Recent advancements in wearable technology have introduced skin-interfaced biosensors capable of analyzing sweat and skin biomarkers,providing innovative solutions for diabetes diagnosis and monitoring.This review comprehensively discusses the current developments in noninvasive wearable biosensors,emphasizing simultaneous detection of biochemical biomarkers(such as glucose,cortisol,lactate,branched-chain amino acids,and cytokines)and physiological signals(including heart rate,blood pressure,and sweat rate)for accurate,personalized diabetes management.We explore innovations in multimodal sensor design,materials science,biorecognition elements,and integration techniques,highlighting the importance of advanced data analytics,artificial intelligence-driven predictive algorithms,and closed-loop therapeutic systems.Additionally,the review addresses ongoing challenges in biomarker validation,sensor stability,user compliance,data privacy,and regulatory considerations.A holistic,multimodal approach enabled by these next-generation wearable biosensors holds significant potential for improving patient outcomes and facilitating proactive healthcare interventions in diabetes management.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea Government(MSIT)(No.NRF-2021R1A2C2004109)the Korea Institute for Advancement of Technology(KIAT)grant funded by the Korea Government(MOTIE)(No.P0020612,2022 The Competency Development Program for Industry Specialist).
文摘Wearable biosensors have received great interest as patient-friendly diagnostic technologies because of their high flexibility and conformability.The growing research and utilization of novel materials in designing wearable biosensors have accelerated the development of point-of-care sensing platforms and implantable biomedical devices in human health care.Among numerous potential materials,conjugated polymers(CPs)are emerging as ideal choices for constructing high-performance wearable biosensors because of their outstanding conductive and mechanical properties.Recently,CPs have been extensively incorporated into various wearable biosensors to monitor a range of target biomolecules.However,fabricating highly reliable CP-based wearable biosensors for practical applications remains a significant challenge,necessitating novel developmental strategies for enhancing the viability of such biosensors.Accordingly,this review aims to provide consolidated scientific evidence by summarizing and evaluating recent studies focused on designing and fabricating CP-based wearable biosensors,thereby facilitating future research.Emphasizing the superior properties and benefits of CPs,this review aims to clarify their potential applicability within this field.Furthermore,the fundamentals and main components of CP-based wearable biosensors and their sensing mechanisms are discussed in detail.The recent advancements in CP nanostructures and hybridizations for improved sensing performance,along with recent innovations in next-generation wearable biosensors are highlighted.CPbased wearable biosensors have been—and will continue to be—an ideal platform for developing effective and user-friendly diagnostic technologies for human health monitoring.
基金supported by the start-up funds from Westlake University to CenBRAIN lab and Bright Dream Joint Institute for Intelligent Robotics.
文摘Continuous drug monitoring is a promising alternative to current therapeutic drug monitoring strategies and has a strong potential to reshape our understanding of pharmacokinetic variability and to improve individualised therapy.This review highlights recent advances in biosensing technologies that support continuous drug monitoring in real time.We focus primarily on aptamer-based biosensors,wearable and implantable devices.Emphasis is given to the approaches employed in constructing biosensors.We pay attention to sensors’biocompatibility,calibration performance,long-term characteristics stability and measurement quality.Last,we discuss the current challenges and issues to be addressed in continuous drug monitoring to make it a promising,future tool for individualised therapy.The ongoing efforts are expected to result in fully integrated implantable drug biosensing technology.Thus,we may anticipate an era of advanced healthcare in which wearable and implantable biochips will automatically adjust drug dosing in response to patient health conditions,thus enabling the management of diseases and enhancing individualised therapy.
基金supported by the National Key Research and Development Program of China (No. 2020YFC2004600, No. 2018YFE0205000)the National Natural Science Foundation of China (No. 81571766)+1 种基金the Natural Science Foundation of Tianjin (No. 17JCYBJC24400)the 111 Project of China (No. B07014)。
文摘In recent years, analyses of sweat have become more popular since it doesn't require invasive sampling procedures. Although blood still remains the golden standards in clinical, analyses of other common body fluids,such as sweat, have become increasingly important. Because the compositions of sweat and blood are osmotically related, the content of certain metabolites in sweat can directly reflect the disease. Sweat detection can be used as an alternative to blood detection and allows continuous monitoring. Increased development of wearable sensors makes it possible for continuous sweat detection. Here, this paper gave a review about the sweat detection methods, such as fluorescence sensing, electrochemical sensing and colorimetric sensing. The advantages and disadvantages of each method and their developing trend in sweat detection were summarized. Then, for the problem of continuous sweat sampling, three methods(capillary force, hydrogel osmotic pump, evaporationdriven micropump) were introduced through different structures of microfluidic chip, and the level of sweat collection and transport achieved by related research was demonstrated. This review aims to provide guidance for future research in sweat detection and stimulate further interest in continuous monitoring of sweat using microfluidic chip.
基金National Natural Science Foundation of China,Grant/Award Number:52103300Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2023A1515010572Shenzhen Science and Technology Program,Grant/Award Numbers:JCYJ20210324132806017,GXWD20220811163904001。
文摘In recent years,wearable electrochemical biosensors have received increasing attention,benefiting from the growing demand for continuous monitoring for personalized medicine and point-of-care medical assistance.Incorporating electrochemical biosensing and corresponding power supply into everyday textiles could be a promising strategy for next-generation non-invasive and comfort interaction mode with healthcare.This review starts with the manufacturing and structural design of electrochemical biosensing textiles and discusses a series of wearable electrochemical biosensing textiles monitoring various biomarkers(e.g.,pH,electrolytes,metabolite,and cytokines)at the molecular level.The fiber-shaped or textile-based solar cells and aqueous batteries as corresponding energy harvesting and storage devices are further introduced as a complete power supply for electrochemical biosensing textiles.Finally,we discuss the challenges and prospects relating to sensing textile systems from wearability,durability,washability,sample collection and analysis,and clinical validation.
基金supported by the National Natural Science Foundation of China(82302345)the Natural Science Foundation Key Project of Zhejiang Province(Z24C130012)。
文摘Continuous cortisol monitoring(CCM)is essential for stress management,providing physiological insights into psychology and physical health.However,promising platform for CCM urges the design of effective biorecognition moieties and the skin integration of sophisticated functions.Herein,we present a computationally-assisted wearable system for CCM(CWSCCM)that leverages cutting-edge interdisciplinary technologies of in-situ regenerative molecularly imprinted polymers(MIP),signal amplifier organic electrochemical transistor(OECT),iontophoresis-based sweat induction,and microfluidic sweat sampling.The highly integrated system incorporated with OECT biosensor enables in-situ MIP regeneration,and offers continuous approach for cortisol monitoring,with an ultra-low limit of detection of0.36 nmol/L.We validated the capability of the CWSCCM for long-term cortisol circadian rhythm monitoring in human participants,which shows superior sensitivity,selectivity,and continuous monitoring capabilities.In conclusion,we demonstrated how computational chemistry and OECT technology can extend the capabilities of current wearable CCM,which could potentially advance closed-loop therapeutics applications.
基金National Natural Science Foundation of China(12374405)Provincial Science Foundation for Distinguished Young Scholars of Fujian(2024J010024)+3 种基金Fuzhou Science and Technology Major Project(2023-ZD-004)Natural Science Foundation of Fujian Province(2023J011267)Joint Funds for the Innovation of Science and Technology,Fujian(2021Y9196)Major Research Projects for Young and Middle-Aged Researchers of Fujian Provincial Health Commission(2021ZQNZD010)。
文摘Wearable sweat sensors that enable non-invasive sampling,efficient and rapid detection,and real-time monitoring capabilities have become an integral and critical component of human health management,with the potential to provide meaningful clinical information related to physiologic diseases in the healthcare field.Here,a flexible nanoplasmonic paper-based sensor based on surface-enhanced Raman scattering(SERS)was developed,in which silver nanoparticles were loaded in the cellulose paper to enhance the Raman signals of targets via the generation of SERS“hotspots.”By incorporating the filter paper channel with a natural core absorbing liquid,the multifunctional chip is formed,which integrates the collection,transmission,and detection of trace sweat.This paperbased chip is soft and stretchable,and fits perfectly onto the human skin surface without causing any damage or irritation.Combined with a hand-held Raman spectrometer,quantitative detection of multiple sweat components can be achieved with the limit of detection of 17 and 1μmol/L for uric acid and glucose,respectively,and the measurable range is 4–7.5 for pH,enabling wearable and in-situ optical sensing for sweat markers under the condition of human physiology and pathology,within only 5 min for uric acid and glucose detection.This wearable biosensor would provide,to our knowledge,a new way for continuously monitoring the health status by collection and analysis of multiple components in human sweat,contributing to point-of-care testing and personalized medicine applications.
基金supported by the National Natural Science Foun-dation of China(Grant 82102511)the Natural Science Foundation of Jiangsu(Grants BK20210021 and BK20210010)Research Project of Jiangsu Province Health Committee(Grant M2021031).
文摘Wearable biosensors,which aim at providing continuous,real-time physiological information via monitoring and screening biomarkers in human body,are receiving increasing attention among various fields including dis-ease treatment,diagnosis and self-health management.The ongoing development in this realm starves for the exploration of fully-integrated,non-invasive devices.In this paper,we review the latest achievements with break-through significance on the wearable biosensors.We start with the classification of different types of wearable electronic devices and analyze their characteristics and application values.Subsequently,we introduce a fully-integrated microneedle-based sensor and provide an in-depth look at its structure,subcomponents and in vivo performances.Finally,we put forward critical commentaries and clarify the direction of future researches.
文摘Wearable and implantable biosensors have emerged as transformative tools in modern healthcare,enabling real-time monitoring of physiological parameters and continuous tracking of biomarkers such as glucose,lactate,and hormones,thereby facilitating early disease detection,personalized treatment plans,and proactive health management[1].The integration of such sensors into daily life holds the promise of revolutionizing patient care by providing immediate feedback and reducing the need for invasive procedures[2].
