Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of life....Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of life.Despite ongoing research,its etiology and pathogenesis remain incompletely understood.Recent advancements in medical research highlight the critical role of drug combination therapies in managing IBD.This paper employs the strengths,weaknesses,opportunities,and threats framework to evaluate the four strategic elements(strengths,weaknesses,opportunities,and threats)pertaining to combination therapies for IBD.Among the strengths,the paper underscores the efficacy of multi-targeted strategies,the advancement of personalized medicine,and the mitigation of drug resistance.Nonetheless,the analysis identifies significant weaknesses,including the prohibitive cost of treatment,issues with patient compliance,and the necessity for comprehensive long-term safety data.The paper also delineates opportunities to augment therapeutic success through the incorporation of biomarkers,the application of artificial intelligence,and extensive international collaborative efforts.In contrast,the paper does not shy away from addressing the threats,which include the potential for therapeutic resistance and the logistical challenges inherent in global therapy deployment.These initiatives aim to refine future therapeutic practices,fostering safer,more effective,and personalized treatment paradigms for IBD patients.展开更多
On the basis of sufficient understanding about the general situation of the Lu＇an planning area, Anhui Province, this paper uses strengths weakness opportunity threats （SWOT） analysis to analyze the internal and ex...On the basis of sufficient understanding about the general situation of the Lu＇an planning area, Anhui Province, this paper uses strengths weakness opportunity threats （SWOT） analysis to analyze the internal and external factors of the development of the planning area itself; then it analyzes the industrial cluster situation in the planning area, and uses GIS space analysis to analyze the industry status of the planning area, integrating it with the geographic space expression to provide references for formulating the economic development program of the Lu＇an planning area.展开更多
pH-fixed titration method for the determination of weak acids and bases has been studied in this paper.It is not necessary to know the ionization constant of weak acid or base and the concentration of titrant. This me...pH-fixed titration method for the determination of weak acids and bases has been studied in this paper.It is not necessary to know the ionization constant of weak acid or base and the concentration of titrant. This method had been applied to determine phenol,4-aminoantipyrine and glycine,whose ionization constants range from 10^(-10)to 10^(-12).The results were satisfactory.展开更多
Bus and any other public transit connectivity issues facilitate an understanding of the importance of transit planning in enhancing existing or new transit services.Improving transit connectivity is one of the most vi...Bus and any other public transit connectivity issues facilitate an understanding of the importance of transit planning in enhancing existing or new transit services.Improving transit connectivity is one of the most vital tasks in transit-operations planning.A poor connection can cause some passengers to stop using the transit service.Service-design criteria always contain postulates to improve routing and scheduling coordination(intra-and inter-agency transfer centers/points and synchronized/timed transfers).Ostensibly the lack of well-defined connectivity measures precludes the weighing and quantifying of the result of any coordination effort.This work provides an initial methodological framework and concepts for(1)quantifying transit connectivity measures and(2)directions and tools for detecting weak segments in inter-route and inter-modal chains(paths)for possible revisions/changes.展开更多
The soft rock's heterogeneity and nonlinear mechanical behavior cause extremely difficult maintenance on the soft rock roadway. Aiming at the asymmetric deformation and destruction phenomenon appearing after excav...The soft rock's heterogeneity and nonlinear mechanical behavior cause extremely difficult maintenance on the soft rock roadway. Aiming at the asymmetric deformation and destruction phenomenon appearing after excavating and supporting the 7101 air return way in Meihe mine, this paper comprehensively adopted a variety of methods to analyze the roadway surrounding rock deformation rule, obtaining the roadway surrounding rock stress and plastic zone distribution rule under no supporting condition and the roadway surrounding rock deformation features under original symmetric supporting condition.Furthermore, this paper revealed the catastrophe mechanism, and proposed the concept of ‘‘weak structure'' and the disaster countermeasure of ‘‘overall stabilizing the roadway and strengthening the support of weak structure''. The industrial test shows that the disaster control technology can realize the coordination deformation of the supporting structure and roadway surrounding rock, thus significantly controlling the deformation of roadway surrounding rock.展开更多
This study aims to assess the small ruminant value chain in Al-Ruwaished District,Jordan,to identify the potential intervention areas that could improve the production efficiency and guarantee the sustainability of th...This study aims to assess the small ruminant value chain in Al-Ruwaished District,Jordan,to identify the potential intervention areas that could improve the production efficiency and guarantee the sustainability of the small ruminant sector in this area.Sheep breeding is the source of livelihood for most of the people in Al-Ruwaished District,which is characterized by the large number of sheep and goats.We surveyed 5.0% of the small ruminant holders in the study area and conducted individual interviews and surveys with the potential actors in the value chain to undertake a small ruminant value chain analysis.From the survey,we found that the small ruminant value chain consists of five core functions,namely,input supply,production management,marketing,processing,and consumption.Despite the stable impression given by the large number of holdings in the small ruminant sector,the surveyed results show a clear fragility in the value chain of small ruminants in this area.The small ruminant production system is negatively impacted by climate change,especially continuous drought.In addition,the high prices of feed that the farmer cannot afford with clear and real absence of the governmental and non-governmental support activities also impact the development of the value chain.The results of strengths,weaknesses,opportunities,and threats(SWOT)analysis reveal that the major constraints faced by this value chain could be divided into external and internal threats.Specifically,the most prominent external threats are the nature of the desert land and continuous drought,while the major internal threats are the absence of appropriate infrastructure,shortage of inputs,and weakness in the production management and marketing.We proposed solutions to these challenges to ensure the sustainability and effectiveness of the sector,such as the formulation of emergency response plans to severe weather,qualifying farmers’skills,and establishment of agricultural cooperative societies.展开更多
This paper mainly investigates the application of predator-prey systems.By deriving the first-order principles of the stochastic partial differential equa-tions,we analyzed the stability of the model at the equilibriu...This paper mainly investigates the application of predator-prey systems.By deriving the first-order principles of the stochastic partial differential equa-tions,we analyzed the stability of the model at the equilibrium point.The co-efficients of the outgoing amplitude equation were deduced using the Wake-field nonlinear analysis.The model was numerically simulated by setting pa-rameters using the nine-point difference method,and the simulation results are in agreement with the numerical results.In addition,a marine predator-prey model combining the fear effect and refuge environment is proposed in this paper,and the pattern formation mechanism of species coexistence is re-vealed through theoretical analysis and numerical simulation.展开更多
文摘Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of life.Despite ongoing research,its etiology and pathogenesis remain incompletely understood.Recent advancements in medical research highlight the critical role of drug combination therapies in managing IBD.This paper employs the strengths,weaknesses,opportunities,and threats framework to evaluate the four strategic elements(strengths,weaknesses,opportunities,and threats)pertaining to combination therapies for IBD.Among the strengths,the paper underscores the efficacy of multi-targeted strategies,the advancement of personalized medicine,and the mitigation of drug resistance.Nonetheless,the analysis identifies significant weaknesses,including the prohibitive cost of treatment,issues with patient compliance,and the necessity for comprehensive long-term safety data.The paper also delineates opportunities to augment therapeutic success through the incorporation of biomarkers,the application of artificial intelligence,and extensive international collaborative efforts.In contrast,the paper does not shy away from addressing the threats,which include the potential for therapeutic resistance and the logistical challenges inherent in global therapy deployment.These initiatives aim to refine future therapeutic practices,fostering safer,more effective,and personalized treatment paradigms for IBD patients.
基金Supported by the National Natural Science Foundation of China(41101407)the Natural Science Foundation of Hubei Province(2014CFB377,2010CDZ005)
文摘On the basis of sufficient understanding about the general situation of the Lu＇an planning area, Anhui Province, this paper uses strengths weakness opportunity threats （SWOT） analysis to analyze the internal and external factors of the development of the planning area itself; then it analyzes the industrial cluster situation in the planning area, and uses GIS space analysis to analyze the industry status of the planning area, integrating it with the geographic space expression to provide references for formulating the economic development program of the Lu＇an planning area.
文摘pH-fixed titration method for the determination of weak acids and bases has been studied in this paper.It is not necessary to know the ionization constant of weak acid or base and the concentration of titrant. This method had been applied to determine phenol,4-aminoantipyrine and glycine,whose ionization constants range from 10^(-10)to 10^(-12).The results were satisfactory.
文摘Bus and any other public transit connectivity issues facilitate an understanding of the importance of transit planning in enhancing existing or new transit services.Improving transit connectivity is one of the most vital tasks in transit-operations planning.A poor connection can cause some passengers to stop using the transit service.Service-design criteria always contain postulates to improve routing and scheduling coordination(intra-and inter-agency transfer centers/points and synchronized/timed transfers).Ostensibly the lack of well-defined connectivity measures precludes the weighing and quantifying of the result of any coordination effort.This work provides an initial methodological framework and concepts for(1)quantifying transit connectivity measures and(2)directions and tools for detecting weak segments in inter-route and inter-modal chains(paths)for possible revisions/changes.
基金provided by the National Natural Science Foundation of China(Nos.51204166 and51174195)the Jiangsu Province ordinary university graduate research innovation projects(No.CXZZ12_0954)
文摘The soft rock's heterogeneity and nonlinear mechanical behavior cause extremely difficult maintenance on the soft rock roadway. Aiming at the asymmetric deformation and destruction phenomenon appearing after excavating and supporting the 7101 air return way in Meihe mine, this paper comprehensively adopted a variety of methods to analyze the roadway surrounding rock deformation rule, obtaining the roadway surrounding rock stress and plastic zone distribution rule under no supporting condition and the roadway surrounding rock deformation features under original symmetric supporting condition.Furthermore, this paper revealed the catastrophe mechanism, and proposed the concept of ‘‘weak structure'' and the disaster countermeasure of ‘‘overall stabilizing the roadway and strengthening the support of weak structure''. The industrial test shows that the disaster control technology can realize the coordination deformation of the supporting structure and roadway surrounding rock, thus significantly controlling the deformation of roadway surrounding rock.
文摘This study aims to assess the small ruminant value chain in Al-Ruwaished District,Jordan,to identify the potential intervention areas that could improve the production efficiency and guarantee the sustainability of the small ruminant sector in this area.Sheep breeding is the source of livelihood for most of the people in Al-Ruwaished District,which is characterized by the large number of sheep and goats.We surveyed 5.0% of the small ruminant holders in the study area and conducted individual interviews and surveys with the potential actors in the value chain to undertake a small ruminant value chain analysis.From the survey,we found that the small ruminant value chain consists of five core functions,namely,input supply,production management,marketing,processing,and consumption.Despite the stable impression given by the large number of holdings in the small ruminant sector,the surveyed results show a clear fragility in the value chain of small ruminants in this area.The small ruminant production system is negatively impacted by climate change,especially continuous drought.In addition,the high prices of feed that the farmer cannot afford with clear and real absence of the governmental and non-governmental support activities also impact the development of the value chain.The results of strengths,weaknesses,opportunities,and threats(SWOT)analysis reveal that the major constraints faced by this value chain could be divided into external and internal threats.Specifically,the most prominent external threats are the nature of the desert land and continuous drought,while the major internal threats are the absence of appropriate infrastructure,shortage of inputs,and weakness in the production management and marketing.We proposed solutions to these challenges to ensure the sustainability and effectiveness of the sector,such as the formulation of emergency response plans to severe weather,qualifying farmers’skills,and establishment of agricultural cooperative societies.
文摘This paper mainly investigates the application of predator-prey systems.By deriving the first-order principles of the stochastic partial differential equa-tions,we analyzed the stability of the model at the equilibrium point.The co-efficients of the outgoing amplitude equation were deduced using the Wake-field nonlinear analysis.The model was numerically simulated by setting pa-rameters using the nine-point difference method,and the simulation results are in agreement with the numerical results.In addition,a marine predator-prey model combining the fear effect and refuge environment is proposed in this paper,and the pattern formation mechanism of species coexistence is re-vealed through theoretical analysis and numerical simulation.
