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COUPLED THERMO-MECHANICAL ANALYSIS OF FUNCTIONALLY GRADIENT WEAK/MICRO-DISCONTINUOUS INTERFACE WITH GRADED FINITE ELEMENT METHOD 被引量:1
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作者 Zhiwen Gao Kang Yong Lee Youhe Zhou 《Acta Mechanica Solida Sinica》 SCIE EI 2012年第4期331-341,共11页
Coupled thermo-mechanical analysis of two bonded functionally graded materials subjected to thermal loads is conducted in this study with the graded finite element method. The thermal-mechanical properties of the bi-m... Coupled thermo-mechanical analysis of two bonded functionally graded materials subjected to thermal loads is conducted in this study with the graded finite element method. The thermal-mechanical properties of the bi-material interfaces are classified based on discontinuity degrees of their material properties and their derivatives at the interfaces. Numerical results indicate that discontinuity exerts remarkable effect on the temperature profile and stress value at the interface of two bonded functionally-graded materials. Under the thermal flux loading conditions, the stronger the interface discontinuity is, the smaller the heat flux is. 展开更多
关键词 functionally graded material thermo-mechanical analysis weak/micro discontin-uous graded finite element method
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STRESS INTENSITY FACTOR OF AN ANTI-PLANE CRACK PARALLEL TO THE WEAK/MICRO-DISCONTINUOUS INTERFACE IN A BI-FGM COMPOSITE 被引量:2
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作者 Yong-Dong Li Wei Tan Kang Yong Lee 《Acta Mechanica Solida Sinica》 SCIE EI 2008年第1期34-43,共10页
The problem considered is a mode Ⅲ crack lying parallel to the interface of an exponential-type functional graded material (FGM) strip bonded to a linear-type FGM substrate with infinite thickness. By applying the ... The problem considered is a mode Ⅲ crack lying parallel to the interface of an exponential-type functional graded material (FGM) strip bonded to a linear-type FGM substrate with infinite thickness. By applying the Fourier integral transform, the problem was reduced as a Cauchy singular integral equation with an unknown dislocation density function. The collocation method based on Chebyshev polynomials proposed by Erdogan and Gupta was used to solve the singular integral equation numerically. With the numerical solution, the effects of the geometrical and physical parameters on the stress intensity factor (SIF) were analyzed and the following conclusions were drawn: (a) The region affected by the interface or free surface varies with the material rigidity, and higher material rigidity will lead to bigger affected region. (b) The SIF of the crack in the affected region and parallel to the micro-discontinuous interface is lower than those of the weak discontinuous cases. Reducing the weak-discontinuity of the interface will be beneficial to decrease the SIF of the interface-parallel crack in the region affected by the interface. (c) The effect of the free surface on SIF is more remarkable than that of the interface, and the latter is still more notable than that of the material rigidity. When the effects of the interface and free surface are fixed, increase of the material rigidity will enhance the value of SIF. 展开更多
关键词 bi-FGM composite mode crack stress intensity factor weak/mico discontinuity the Cauchy singular integral equation
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人体手舟骨显微形态学特征的Micro CT成像技术分析
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作者 张德洲 吕远 +12 位作者 李琨 陈杰 杨向荣 赵海龙 张少杰 马渊 郝韵腾 杨洋 高明杰 王志强 李志军 史君 王星 《中国组织工程研究》 北大核心 2026年第21期5573-5581,共9页
背景:临床上,由于手舟骨的特殊解剖特点和内部骨小梁分布特征等往往使得骨折的治疗效果普遍不佳,常导致骨折不愈合和缺血性坏死,进而引发腕关节炎和功能丧失。目的:利用Micro CT技术对手舟骨标本进行扫描,分析其内部显微结构特征,测量... 背景:临床上,由于手舟骨的特殊解剖特点和内部骨小梁分布特征等往往使得骨折的治疗效果普遍不佳,常导致骨折不愈合和缺血性坏死,进而引发腕关节炎和功能丧失。目的:利用Micro CT技术对手舟骨标本进行扫描,分析其内部显微结构特征,测量各区域骨小梁显微结构参数值,以发现手舟骨骨小梁的区域差异,旨在为手舟骨骨折的预防、治疗及骨折机制研究提供科学依据。方法:选取5具成人尸体标本的双侧手舟骨(10例)进行Micro CT扫描,通过对手舟骨3个感兴趣区域(结节部、腰部、体部)内骨小梁的勾选与重建,详细观察手舟骨内部的显微形态特征,测量和比较各区域骨小梁显微结构参数值的差异。结果与结论:①Micro CT图像显示手舟骨表面皮质骨相对较薄,内部充满复杂的骨小梁微观结构;靠近皮质骨的板层状骨小梁相对密集,向内部延伸成杆状骨小梁;从矢状面、冠状面和横断面上观察,腰部内骨小梁分布较为稀疏,而体部和结节部内骨小梁分布则更为致密;②手舟骨结节部的骨体积分数、骨表面积、骨表面积组织体积比、骨小梁分离度、骨小梁数目、骨小梁连通性、骨小梁连接密度、分形维数、骨矿物质密度和骨矿物质含量在左右侧别间比较差异均有显著性意义(P<0.05);腰部和体部的各骨小梁显微结构参数值在左右侧别间比较差异均无显著性意义(P>0.05);③手舟骨的骨体积、骨体积分数、骨表面积、骨表面积组织体积比、骨表面积骨体积比、骨矿物质密度和骨矿物质含量在体部与结节部、腰部之间比较差异有显著性意义(P<0.05);手舟骨的骨小梁厚度在体部与结节部之间比较差异有显著性意义(P<0.05);手舟骨的骨小梁分离度、分形维数在体部与结节部、腰部,结节部与腰部之间差异有显著性意义(P<0.05);手舟骨的骨小梁数目、骨小梁连通性、骨小梁连接密度在腰部与结节部、体部之间比较差异有显著性意义(P<0.05);手舟骨的组织体积、各向异性程度在体部、结节部、腰部之间比较差异均无显著性意义(P>0.05);④结果显示,手舟骨的骨小梁显微结构参数值存在区域性差异,其中腰部的骨密度和强度较低,是最容易发生骨折的部位,该发现从骨小梁微观结构角度为理解手舟骨骨折机制提供了理论依据;同时,此次研究揭示的手舟骨不同部位的骨小梁结构特征也为设计针对性的内固定器械提供了理论依据。 展开更多
关键词 手舟骨 micro CT 显微形态 骨小梁 区域差异 骨小梁显微结构
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超声定量参数、sTWEAK联合预测急性心肌梗死患者并发心力衰竭价值
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作者 张曦 朱晓玲 《影像科学与光化学》 2026年第1期66-71,78,共7页
目的:探讨超声定量参数、可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)联合预测急性心肌梗死(AMI)患者并发心力衰竭(HF)价值,以辅助临床决策,降低HF发生风险。方法:选取2021年5月至2023年5月自贡市第四人民医院收治的116例AMI患者作为... 目的:探讨超声定量参数、可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)联合预测急性心肌梗死(AMI)患者并发心力衰竭(HF)价值,以辅助临床决策,降低HF发生风险。方法:选取2021年5月至2023年5月自贡市第四人民医院收治的116例AMI患者作为研究组(AMI患者组),另遵循1:1原则纳入同期116例冠脉造影正常者作为对照组(冠脉造影正常组)。比较两组入院即刻彩超参数[左心室射血分数(LVEF)、左室收缩末期内径(LVEDD)、室壁运动积分(WMS)]、实时心肌造影(MCE)参数[心肌血流量(A·β)、时间-强度曲线上升斜率(β)、灌注计分指数(PSI)]、sTWEAK,同时根据AMI发病3周内是否发生HF,分为HF亚组和非HF亚组,统计两亚组一般资料、入院即刻超声定量参数、sTWEAK,采用偏相关性分析超声定量参数、sTWEAK与HF之间关系,采用受试者操作特征曲线及曲线下面积(AUC)分析预测效能。结果:(1)研究组血清sT-WEAK表达及LVEDD、WMS较对照组高,A·β、β、PSI、LVEF较对照组低(P<0.05);(2)两组亚组梗死位置、多支血管闭塞(≥2支)、sTWEAK、MCE参数、彩超参数上存在显著差异(P<0.05);(3)控制梗死位置、多支血管闭塞(≥2支)等混杂因素后,sTWEAK与HF发生呈正相关,A·β、PSI、LVEF与HF发生呈负相关(P<0.05);(4)sTWEAK、A·β、PSI、LVEF四者联合预测HF的AUC最大,值为0.934,敏感度及特异度分别为87.50%、88.16%。结论:超声定量参数、sTWEAK在AMI患者中呈异常表达,四者联合可提高HF的预测效能,为临床决策提供依据,有助于降低HF发生风险。 展开更多
关键词 急性心肌梗死 心力衰竭 彩超 实时心肌造影 可溶性肿瘤坏死因子样凋亡弱诱导因子
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距骨不同区域骨小梁形态特征的Micro-CT评估
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作者 李磊 张凤珍 +10 位作者 尹兆正 伊钰营 申晓科 段博 王志强 任小燕 李琨 李志军 王奇娇 王星 张少杰 《中国组织工程研究》 北大核心 2026年第15期3946-3952,共7页
背景:距骨骨折治疗难度大,易出现多种并发症,导致预后不良,故需进一步了解距骨内骨小梁分布特征及其与骨折发生的关系。目的:利用Micro-CT技术对距骨标本进行扫描,观测骨小梁结构特征及形态计量学参数,探讨距骨不同区域的骨小梁差异,为... 背景:距骨骨折治疗难度大,易出现多种并发症,导致预后不良,故需进一步了解距骨内骨小梁分布特征及其与骨折发生的关系。目的:利用Micro-CT技术对距骨标本进行扫描,观测骨小梁结构特征及形态计量学参数,探讨距骨不同区域的骨小梁差异,为距骨骨折的预防、治疗及骨折机制研究提供依据。方法:选取53例成人距骨标本进行Micro-CT扫描,将影像资料导入Avata软件进行三维重建,通过对距骨头部、颈部、体部3个感兴趣区域内骨小梁的勾选与重建,观察其形态特征,并测量分析不同区域骨小梁形态计量学参数的差异。结果与结论:①距骨的Micro-CT扫描影像显示其头部和体部的皮质骨较薄,而颈部的皮质骨则相对较厚;颈部的骨小梁分布较为稀疏,而头部和体部的骨小梁则相对致密;②距骨骨小梁的骨体积、骨体积分数、骨小梁模式因子在头部与颈部、体部间比较差异均有显著性意义(P<0.05);距骨骨小梁的骨表面积、骨表面积组织体积比、骨小梁分离度、分形维数在颈部与头部、体部间比较差异均有显著性意义(P<0.05);距骨骨小梁的骨小梁厚度在体部与头部、颈部之间比较差异有显著性意义(P<0.05);距骨骨小梁的骨表面积骨体积比、骨小梁厚度、骨小梁连通性、骨小梁连接密度、各向异性程度、结构模型指数在颈部与头部、体部,头部与体部间比较差异均有显著性意义(P<0.05);③提示Micro-CT技术能够定量分析距骨不同区域骨小梁形态的计量学参数,距骨的骨小梁形态计量学参数存在区域性差异,颈部的骨小梁数量和强度较低,是最容易发生骨折的部位,从骨小梁分布特征说明了距骨骨折好发于颈部。 展开更多
关键词 距骨 micro-CT 骨小梁 区域差异 形态计量学参数
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McKean-Vlasov Backward Stochastic Differential Equations with Weak Monotonicity Coefficients
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作者 FU Zongkui FEI Dandan GUO Shanshan 《应用数学》 北大核心 2026年第1期98-107,共10页
This paper deals with Mckean-Vlasov backward stochastic differential equations with weak monotonicity coefficients.We first establish the existence and uniqueness of solutions to Mckean-Vlasov backward stochastic diff... This paper deals with Mckean-Vlasov backward stochastic differential equations with weak monotonicity coefficients.We first establish the existence and uniqueness of solutions to Mckean-Vlasov backward stochastic differential equations.Then we obtain a comparison theorem in one-dimensional situation. 展开更多
关键词 McKean-Vlasov backward stochastic differential equation weak monotonicity condition Comparison theorem
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Micro/nanoplastics and eye health:a review
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作者 Lun He Jiang Zheng +6 位作者 Xiao-Kun Han Tian-Yu Tao Jing Zeng Wei Luo Xin Chen Jun-Ming Wang Xiang-Yin Sha 《International Journal of Ophthalmology(English edition)》 2026年第2期405-413,共9页
Micro/nanoplastics(M/NPs)have become pervasive environmental pollutants,posing significant risks to human health through various exposure routes,including ingestion,inhalation,and direct contact.This review systematic... Micro/nanoplastics(M/NPs)have become pervasive environmental pollutants,posing significant risks to human health through various exposure routes,including ingestion,inhalation,and direct contact.This review systematically examined the potential impacts of M/NPs on ocular health,focusing on exposure pathways,toxicological mechanisms,and resultant damage to the eye.Ocular exposure to M/NPs can occur via direct contact and oral ingestion,with the latter potentially leading to the penetration of particles through ocular biological barriers into ocular tissues.The review highlighted that M/NPs can induce adverse effects on the ocular surface,elevate intraocular pressure,and cause abnormalities in the vitreous and retina.Mechanistically,oxidative stress and inflammation are central to M/NP-induced ocular damage,with smaller particles often exhibiting greater toxicity.Overall,this review underscored the potential risks of M/NPs to ocular health and emphasized the need for further research to elucidate exposure mechanisms,toxicological pathways,and mitigation strategies. 展开更多
关键词 micro/nanoplastics EXPOSURE OCULAR TOXICITY
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Superelastic and Washable Micro/Nanofibrous Sponges Based on Biomimetic Helical Fibers for Efficient Thermal Insulation
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作者 Fengjin Yang Zhifei Wang +7 位作者 Wei Zhang Sai Wang Yi‑Tao Liu Fei Wang Roman ASurmenev Jianyong Yu Shichao Zhang Bin Ding 《Nano-Micro Letters》 2026年第2期170-182,共13页
Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always... Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always struggle to balance mechanical properties and thermal insulation,resulting in their inability to meet the demands for both washing resistance and personal protection.Herein,inspired by the natural spring-like structures of cucumber tendrils,a superelastic and washable micro/nanofibrous sponge(MNFS)based on biomimetic helical fibers is directly prepared utilizing multiple-jet electrospinning technology for high-performance thermal insulation.By regulating the conductivity of polyvinylidene fluoride solution,multiple-jet ejection and multiple-stage whipping of jets are achieved,and further control of phase separation rates enables the rapid solidification of jets to form spring-like helical fibers,which are directly entangled to assemble MNFS.The resulting MNFS exhibits superelasticity that can withstand large tensile strain(200%),1000 cyclic tensile or compression deformations,and retain good resilience even in liquid nitrogen(-196℃).Furthermore,the MNFS shows efficient thermal insulation with low thermal conductivity(24.85 mW m^(-1)K^(-1)),close to the value of dry air,and remains structural stability even after cyclic washing.This work offers new possibilities for advanced fibrous sponges in transportation,environmental,and energy applications. 展开更多
关键词 ELECTROSPINNING micro/nanofibrous sponge Hierarchical structure SUPERELASTICITY Thermal insulation
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Micro/Nano‑Reconfigurable Robots for Intelligent Carbon Management in Confined‑Space Life‑Support Systems
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作者 Wei Lu Rimei Chen +5 位作者 Lianlong Zhan Qin Xiang Renting Huang Lei Wang Shuangfei Wang Hui He 《Nano-Micro Letters》 2026年第3期210-226,共17页
Strategically coupling nanoparticle hybrids and internal thermosensitive molecular switches establishes an innovative paradigm for constructing micro/nanoscale-reconfigurable robots,facilitating energyefficient CO_(2)... Strategically coupling nanoparticle hybrids and internal thermosensitive molecular switches establishes an innovative paradigm for constructing micro/nanoscale-reconfigurable robots,facilitating energyefficient CO_(2) management in life-support systems of confined space.Here,a micro/nano-reconfigurable robot is constructed from the CO_(2) molecular hunters,temperature-sensitive molecular switch,solar photothermal conversion,and magnetically-driven function engines.The molecular hunters within the molecular extension state can capture 6.19 mmol g^(−1) of CO_(2) to form carbamic acid and ammonium bicarbonate.Interestingly,the molecular switch of the robot activates a molecular curling state that facilitates CO_(2) release through nano-reconfiguration,which is mediated by the temperature-sensitive curling of Pluronic F127 molecular chains during the photothermal desorption.Nano-reconfiguration of robot alters the amino microenvironment,including increasing surface electrostatic potential of the amino group and decreasing overall lowest unoccupied molecular orbital energy level.This weakened the nucleophilic attack ability of the amino group toward the adsorption product derivatives,thereby inhibiting the side reactions that generate hard-to-decompose urea structures,achieving the lowest regeneration temperature of 55℃ reported to date.The engine of the robot possesses non-contact magnetically-driven micro-reconfiguration capability to achieve efficient photothermal regeneration while avoiding local overheating.Notably,the robot successfully prolonged the survival time of mice in the sealed container by up to 54.61%,effectively addressing the issue of carbon suffocation in confined spaces.This work significantly enhances life-support systems for deep-space exploration,while stimulating innovations in sustainable carbon management technologies for terrestrial extreme environments. 展开更多
关键词 micro/nano RECONFIGURABLE Robot Confined space CO_(2)management Efficient regeneration
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CO_(2)nanobubble-enhanced cement-fly ash backfill:Optimizing aggregate gradation and microstructure
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作者 Xiaoxiao Cao Haoyan Lyu +4 位作者 Yanlong Chen Jiangyu Wu Hideki Shimada Takashi Sasaoka Akihiro Hamanaka 《International Journal of Minerals,Metallurgy and Materials》 2026年第1期129-140,共12页
Mine filling materials urgently need to improve mechanical properties and achieve low-carbon transformation.This study explores the mechanism of the synergistic effect of optimizing aggregate fractal grading and intro... Mine filling materials urgently need to improve mechanical properties and achieve low-carbon transformation.This study explores the mechanism of the synergistic effect of optimizing aggregate fractal grading and introducing CO_(2)nanobubble technology to improve the performance of cement-fly ash-based backfill materials(CFB).The properties including fluidity,setting time,uniaxial compressive strength,elastic modulus,porosity,microstructure and CO_(2)storage performance were systematically studied through methods such as fluidity evaluation,time test,uniaxial compression test,mercury intrusion porosimetry(MIP),scanning electron microscopy-energy dispersive spectroscopy analysis(SEM-EDS),and thermogravimetric-differential thermogravimetric analysis(TG-DTG).The experimental results show that the density and strength of the material are significantly improved under the synergistic effect of fractal dimension and CO_(2)nanobubbles.When the fractal dimension reaches 2.65,the mass ratio of coarse and fine aggregates reaches the optimal balance,and the structural density is greatly improved at the same time.At this time,the uniaxial compressive strength and elastic modulus reach their peak values,with increases of up to 13.46%and 27.47%,respectively.CO_(2)nanobubbles enhance the material properties by promoting hydration reaction and carbonization.At the microscopic level,CO_(2)nanobubble water promotes the formation of C-S-H(hydrated calcium silicate),C-A-S-H(hydrated calcium aluminium silicate)gel and CaCO_(3),which is the main way to enhance the performance.Thermogravimetric studies have shown that when the fractal dimension is 2.65,the dehydration of hydration products and the decarbonization process of CaCO_(3)are most obvious,and CO_(2)nanobubble water promotes the carbonization reaction,making it surpass the natural state.The CO_(2)sequestration quality of cement-fly ash-based materials treated with CO_(2)nanobubble water at different fractal dimensions increased by 12.4wt%to 99.8wt%.The results not only provide scientific insights for the design and implementation of low-carbon filling materials,but also provide a solid theoretical basis for strengthening green mining practices and promoting sustainable resource utilization. 展开更多
关键词 cement-fly ash-based backfill CO_(2)nanobubble fractal dimension macro and micro performance carbon sequestration
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Adaptive Grid-Interface Control for Power Coordination in Multi-Microgrid Energy Networks
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作者 Sk.A.Shezan 《Energy Engineering》 2026年第1期91-114,共24页
Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency devia... Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency deviations,voltage fluctuations,and poor reactive power coordination,posing serious challenges to grid stability.Conventional Interconnection FlowControllers(IFCs)primarily regulate active power flowand fail to effectively handle dynamic frequency variations or reactive power sharing in multi-microgrid networks.To overcome these limitations,this study proposes an enhanced Interconnection Flow Controller(e-IFC)that integrates frequency response balancing and an Interconnection Reactive Power Flow Controller(IRFC)within a unified adaptive control structure.The proposed e-IFC is implemented and analyzed in DIgSILENT PowerFactory to evaluate its performance under various grid disturbances,including frequency drops,load changes,and reactive power fluctuations.Simulation results reveal that the e-IFC achieves 27.4% higher active power sharing accuracy,19.6% lower reactive power deviation,and 18.2% improved frequency stability compared to the conventional IFC.The adaptive controller ensures seamless transitions between grid-connected and islanded modes and maintains stable operation even under communication delays and data noise.Overall,the proposed e-IFCsignificantly enhances active-reactive power coordination and dynamic stability in renewable-integrated multi-microgrid systems.Future research will focus on coupling the e-IFC with tertiary-level optimization frameworks and conducting hardware-in-the-loop validation to enable its application in large-scale smart microgrid environments. 展开更多
关键词 Active power flow control interconnection flow controller(IFC) frequency response micro grid stability reactive power management
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Steady‑state microbunching based on transverse‑longitudinal coupling
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作者 Xiu‑Jie Deng Alexander Wu Chao +3 位作者 Wen‑Hui Huang Zi‑Zheng Li Zhi‑Long Pan Chuan‑Xiang Tang 《Nuclear Science and Techniques》 2026年第1期1-49,共49页
In this study,three specific scenarios of a novel accelerator light source mechanism called steady-state microbunching(SSMB)were studied:longitudinal weak focusing,longitudinal strong focusing,and generalized longitud... In this study,three specific scenarios of a novel accelerator light source mechanism called steady-state microbunching(SSMB)were studied:longitudinal weak focusing,longitudinal strong focusing,and generalized longitudinal strong focusing(GLSF).At present,GLSF is the most promising method for realizing high-power short-wavelength coherent radiation with mild requirements on modulation laser power.Its essence is to exploit the ultrasmall natural vertical emittance of an electron beam in a planar storage ring for efficient microbunching formation,like a partial transverse-longitudinal emittance exchange in the optical laser wavelength range.Based on an in-depth investigation of related beam physics,a solution for a GLSF SSMB storage ring that can deliver 1 kW average-power EUV light is presented.The work in this paper,such as the generalized Courant–Snyder formalism,analysis of theoretical minimum emittances,transverse-longitudinal coupling dynamics,and derivation of the bunching factor and modulation strengths for laser-induced microbunching schemes,is expected to be useful not only for the development of SSMB but also for future accelerator light sources in general that demand increasingly precise electron beam phase space manipulations. 展开更多
关键词 Steady-state microbunching Extreme ultraviolet ARPES Generalized Courant-Snyder formalism Theoretical minimum emittances Longitudinal weak focusing Longitudinal strong focusing Generalized longitudinal strong focusing Transverse-longitudinal coupling Damping wiggler
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超声引导下甲状腺结节细针穿刺活检联合microRNA-221检测对甲状腺肿瘤检出率及肿瘤良恶性分级的价值研究
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作者 徐斌胜 占承志 汪倩 《影像科学与光化学》 2026年第1期87-93,共7页
目的:分析超声引导下甲状腺结节细针穿刺活检联合微小核糖核酸-221(microRNA-221)检测对甲状腺肿瘤的检出效能及对肿瘤良恶性分级的价值。方法:选取甲状腺肿瘤患者120例,分为良性组和恶性组,手术前均行超声引导下甲状腺结节细针穿刺活检... 目的:分析超声引导下甲状腺结节细针穿刺活检联合微小核糖核酸-221(microRNA-221)检测对甲状腺肿瘤的检出效能及对肿瘤良恶性分级的价值。方法:选取甲状腺肿瘤患者120例,分为良性组和恶性组,手术前均行超声引导下甲状腺结节细针穿刺活检,并检测microRNA-221表达。比较两组超声引导下细针穿刺活检结果、microRNA-221表达;比较不同超声表现及超声引导下细针穿刺活检分级患者microRNA-221表达;分析各指标单独及联合鉴别甲状腺肿瘤良恶性分级的效能。结果:有42例甲状腺恶性肿瘤、78例甲状腺良性肿瘤;两组超声引导下细针穿刺活检分级比较差异有统计学意义(P<0.05),恶性组Ⅱ级占比低于良性组(P<0.05),Ⅳ级、Ⅴ级、Ⅵ级占比均高于良性组(P<0.05),形态不规则、边界模糊、不均匀低回声、微小钙化患者血清、组织microRNA-221表达均更高(P<0.05),且恶性组血清、组织microRNA-221表达均高于良性组(P<0.05);超声引导下细针穿刺活检分级越高,血清、组织microRNA-221表达也越高;超声引导下细针穿刺活检、血清及组织microRNA-221表达结合诊断甲状腺肿瘤良恶性分级的灵敏度、准确率和AUC均高于单独诊断,特异度与单独诊断基本一致。结论:超声引导下甲状腺结节细针穿刺活检联合血清、组织microRNA-221检测可提高对甲状腺肿瘤良恶性分级的诊断灵敏度、准确率,且效能优于单一诊断。 展开更多
关键词 超声 甲状腺结节 细针穿刺活检 微小核糖核酸-221 甲状腺肿瘤 良恶性分级
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基于专利视角的Micro LED产业技术态势分析
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作者 胡思思 李贞贞 《世界科技研究与发展》 2025年第5期651-662,共12页
Micro LED作为新一代显示技术,凭借高亮度、高分辨率、低功耗等特性成为全球显示产业竞争焦点。本文基于专利计量与BERTopic模型方法,对全球Micro LED技术开展专利分析,从技术分布、创新主体、技术主题、法律状态、价值分布等多个维度,... Micro LED作为新一代显示技术,凭借高亮度、高分辨率、低功耗等特性成为全球显示产业竞争焦点。本文基于专利计量与BERTopic模型方法,对全球Micro LED技术开展专利分析,从技术分布、创新主体、技术主题、法律状态、价值分布等多个维度,系统梳理了该领域的发展现状与趋势。研究表明:中国的专利申请量占据全球主导地位,但高价值专利仍集中于美国和日本等发达国家;显示设备、量子点/全彩化、显示应用、材料与元器件、芯片及显示屏六大领域是专利技术重点细分方向;巨量转移、全彩显示等关键技术仍处于突破阶段,产业生态需进一步完善;光电子与集成电路、人工智能等电子信息技术的深度融合进一步驱动Micro LED技术向高精度、高集成度方向发展。基于分析结果,本文从核心技术突破、产学研协同机制、差异化应用场景、国际竞争力提升等方面提出建议,为中国Micro LED产业高质量发展提供参考。 展开更多
关键词 micro LED 专利分析 BERTopic 巨量转移 全彩显示
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The Quantification of Micro-structural Damage of Weak Muddy Intercalation in Dry-wet Cycles Combining in-situ SEM and DIP 被引量:1
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作者 HE Leping ZHONG Lin +3 位作者 HU Qijun GU Yucheng ZENG Junsen TANG Wei 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2019年第6期1396-1399,共4页
In order to reflect truly the damage evolution mechanism of weak muddy intercalation in dry-wet cycles, two typical weak muddy intercalations were selected for dry-wet cycles. The mineral changes of specimens were ana... In order to reflect truly the damage evolution mechanism of weak muddy intercalation in dry-wet cycles, two typical weak muddy intercalations were selected for dry-wet cycles. The mineral changes of specimens were analyzed via X-ray diffraction after dry-wet cycles. By combining in-situ SEM and digital image processing(DIP), the damage evolution process and damage characteristic parameters of each stage were obtained. The experimental results indicate that the hydration and dissolution of minerals can not be a determinant factor in structure damage. The micro-structural damage is due to disintegration of mineral aggregates, leading to changes in the number and size of cracks and pores. The damage degree of specimens is related to its initial structure, and the micro-structural damage intensifies and finally tends to stabilize with cycle times increased. 展开更多
关键词 dry-wet cycles weak muddy intercalation in-situ SEM digital image processing microstructural damage
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Micro LED表面缺陷的快速高精度检测 被引量:3
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作者 赵天元 董登峰 +2 位作者 王国名 王博 周维虎 《光学精密工程》 北大核心 2025年第9期1434-1445,共12页
为了满足Micro LED缺陷检测对实时性和高精度的要求,结合轻量化的设计和增强的特征提取能力,提出了一种快速高精度的检测算法LED-YOLO。该方法通过设计图像采集系统并结合多种数据增广策略,模拟工业环境中的实际干扰,增强了训练数据的... 为了满足Micro LED缺陷检测对实时性和高精度的要求,结合轻量化的设计和增强的特征提取能力,提出了一种快速高精度的检测算法LED-YOLO。该方法通过设计图像采集系统并结合多种数据增广策略,模拟工业环境中的实际干扰,增强了训练数据的多样性。针对Micro LED缺陷的低区分度问题,提出了轻量级动态融合模块(Lightweight Dynamic Fusion Module,LDFM),该模块结合动态卷积、深度卷积和通道混合操作,在保持模型轻量化的同时,提升了特征表达能力。为了进一步加强缺陷区域的关注,设计了增强协调注意力模块(Enhanced Coordinate Attention Module,ECAM),通过结合通道和空间注意力机制及残差连接,增强了特征提取的准确性。最后,考虑到Micro LED图像的纵横比变化较小,引入动态聚焦机制,提出了DIoU_W回归损失函数,显著提高了模型的收敛速度和稳定性。实验结果表明,LED-YOLO的检测准确率、召回率、mAP、F1值均优于目前最先进的YOLOv11s模型,在参数量减少1.6 M的情况下,检测速度和检测精度均有明显提升,可以有效满足实际Micro LED面板制造过程的质量检验需求。 展开更多
关键词 深度学习 micro LED 缺陷检测 动态卷积 注意力机制
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TWEAK、KIM-1及RPR与系统性红斑狼疮患儿疾病活动程度、肾损伤的相关性分析 被引量:1
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作者 赵申 李俊杰 《中国免疫学杂志》 北大核心 2025年第3期675-679,共5页
目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另... 目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另收集同期40例健康体检新生儿作为对照组;将SLE患儿根据系统性红斑狼疮疾病活动指数(SLEDAI)评分分为(≤9分)24例和高疾病活动度组(>9分)18例,根据是否伴有肾脏损害分为LN组31例和非LN组11例。检测所有受试对象红细胞分布宽度(RDW)和血小板计数(PLT),并计算RPR;ELISA法检测血清TWEAK、KIM-1水平。结果:SLE组血清TWEAK、KIM-1及RPR水平均显著高于对照组(P<0.05);高疾病活动度组SLE患儿血清TWEAK、KIM-1及RPR水平均显著高于低疾病活动度组(P<0.05);LN组患儿血清TWEAK、KIM-1及RPR水平均显著高于非LN组(P<0.05)。相关性分析显示,RPR与SLEDAI评分呈显著正相关(P<0.05),TWEAK、KIM-1与24 h尿蛋白呈显著正相关(P<0.05)。RPR评估SLE高疾病活动度的AUC为0.744(95%CI 0.657~0.818),显著大于TWEAK、KIM-1评估的AUC分别为0.678(95%CI:0.588~0.760)和0.598(95%CI:0.505~0.686,P<0.05);TWEAK和KIM-1预测LN的AUC分别为0.847(95%CI:0.773~0.905)和0.773(95%CI:0.690~0.842),显著大于RPR预测的AUC为0.645(95%CI:0.555~0.727,P<0.05)。结论:SLE患儿存在TWEAK、KIM-1及RPR水平变化,其中RPR对SLE疾病活动度具有较高的诊断效能,而TWEAK和KIM-1对LN预测价值较高。 展开更多
关键词 系统性红斑狼疮 肿瘤坏死因素样凋亡微弱诱导剂 肾损伤因子1 红细胞分布宽度/血小板比值 疾病活动度 狼疮性肾炎
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Microscopic sand production simulation and visual sanding pattern description in weakly consolidated sandstone reservoirs 被引量:5
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作者 Chang-Yin Dong Bo Zhou +4 位作者 Fan-Sheng Huang Lei Zhang Yi-Zhong Zhao Yang Song Jun-Yu Deng 《Petroleum Science》 SCIE CAS CSCD 2022年第1期279-295,共17页
To visually describe the sanding pattern,this study constructs a new particle-scale microstructure model of weakly consolidated formation,and develop the corresponding methodology to simulate the sanding process and p... To visually describe the sanding pattern,this study constructs a new particle-scale microstructure model of weakly consolidated formation,and develop the corresponding methodology to simulate the sanding process and predict sand cavity shape.The microstructure model is a particle-objective model,which focuses on the random sedimentation of every sand grain.In the microstructure,every particle has its own size,sphericity and inclination angle.It is used to simulate the actual structure of cemented granular materials,which considers the heterogeneity and randomness of reservoir properties,provides the initial status for subsequent sanding simulation.With the particle detachment criteria,the microscopic simulation of sanding can be visually implemented to investigate the pattern and cavity shapes caused by sand production.The results indicate that sanding always starts initially from the borehole border,and then extends along the weakly consolidated plane,showing obvious characteristic of randomness.Three typical microscopic sanding patterns,concerning pore liquefaction,pseudo wormhole and continuous collapse,are proposed to illustrate the sanding mechanism in weakly consolidated reservoirs.The nonuniformity of sanding performance depends on the heterogeneous distribution of reservoir properties,such as rock strength and particle size.Finally,the three sanding patterns are verified by visually experimental work.The proposed integrated methodology is capable of predicting and describing the sanding cavity shape of an oil well after long-term sanding production,and providing the focus objective of future sand control measure. 展开更多
关键词 weakly consolidated reservoir Particle-scale microstructure model microcosmic sanding process simulation Visual sanding cavity description Sanding prediction Sand control optimization
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Effect of a weak magnetic field on ductile-brittle transition in micro-cutting of single-crystal calcium fluoride 被引量:1
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作者 Yunfa Guo Yan Jin Lee +3 位作者 Yu Zhang Anastassia Sorkin Sergei Manzhos Hao Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第17期96-113,共18页
Magneto-plasticity occurs when a weak magnetic field alters material plasticity and offers a viable solution to enhance ductile-mode cutting of brittle materials.This study demonstrates the susceptibility of non-magne... Magneto-plasticity occurs when a weak magnetic field alters material plasticity and offers a viable solution to enhance ductile-mode cutting of brittle materials.This study demonstrates the susceptibility of non-magnetic single-crystal calcium fluoride(CaF_(2))to the magneto-plastic effect.The influence of magneto-plasticity on CaF_(2) was confirmed in micro-deformation tests under a weak magnetic field of 20 mT.The surface pile-up effect was weakened by 10-15 nm along with an enlarged plastic zone and suppressed crack propagation under the influence of the magnetic field.Micro-cutting tests along different crystal orientations on the(111)plane of CaF_(2) revealed an increase in the ductile-brittle transition of the machined surface with the aid of magneto-plasticity where the largest increase in ductile-brittle transition occurred along the[112]orientation from 512 nm to a range of 664-806 nm.Meanwhile,the subsurface damage layer was concurrently thinner under magnetic influence.An anisotropic influence of the magnetic field relative to the single-crystal orientation and the cutting direction was also observed.An analytical model was derived to determine an orientation factor M that successfully describes the anisotropy while considering the single-crystal dislocation behaviour,material fracture toughness,and the orientation of the magnetic field.Previously suggested theoretical mechanism of magneto-plasticity via formation of non-singlet electronic states in defected configurations was confirmed with density functional theory calculations.The successful findings on the influence of a weak magnetic field on plasticity present an opportunity for the adoption of magnetic-assisted micro-cutting of non-magnetic materials. 展开更多
关键词 Magneto-plasticity weak magnetic field Brittle material Ductile-brittle transition micro-CUTTING
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基于量子点颜色转换层的Micro LED研究进展
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作者 程旭东 陈祖康 +3 位作者 张针霖 朱艳青 徐刚 徐雪青 《新能源进展》 北大核心 2025年第1期107-120,共14页
微发光二极管(Micro LED)显示器是由微米级半导体发光像元阵列所组成的新型显示技术,是显示技术与LED技术复合集成的综合性技术。与液晶显示器和有机发光二极管显示器相比,Micro LED具有对比度高、功耗低、寿命长、响应时间短等优点。然... 微发光二极管(Micro LED)显示器是由微米级半导体发光像元阵列所组成的新型显示技术,是显示技术与LED技术复合集成的综合性技术。与液晶显示器和有机发光二极管显示器相比,Micro LED具有对比度高、功耗低、寿命长、响应时间短等优点。然而,由于LED芯片尺寸缩小至20μm以下,导致其吸收截面减小,使得传统的荧光粉颜色转换技术无法提供足够的亮度和产量,以满足高分辨率显示的需求。而量子点材料凭借其高量子产率、宽色域、颜色可调等优点,有望成为代替荧光粉的最佳材料。结合了量子点颜色转换技术的Micro LED光电器件具有高亮度、高效率和宽色域的优势,在显示领域具有广阔的应用前景。目前许多学界和产业界的研究者对全彩显示的Micro LED进行了深入研究,逐步实现了Micro LED的商业化。简要回顾了广泛应用于显示领域的量子点材料合成和优异性能的重要研究成果,然后以印刷技术、光刻技术、微流控技术、激光写入技术这四种效果突出的颜色转换层沉积工艺分类总结了基于量子点颜色转换技术Micro LED的全彩显示策略与性能优劣。最后,对基于量子点颜色转换层的Micro LED光电器件的应用前景进行了展望。 展开更多
关键词 量子点 micro LED 颜色转换层 全彩显示
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