BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentrax...BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.展开更多
When propagating through anisotropic rocks in the crust, shear-waves split into faster and slower components with almost orthogonal polarizations. For nearly vertical propagation the polarization of fast shear- wave ...When propagating through anisotropic rocks in the crust, shear-waves split into faster and slower components with almost orthogonal polarizations. For nearly vertical propagation the polarization of fast shear- wave （PFS） is parallel to both the strike of the cracks and the direction of maximum horizontal stress, therefore it is possible to use PFS to study stress in the crust. This study discusses several examples in which PFS is applied to deduce the compressive stress in North China, Longmenshan fault zone of east edge of Tibetan plateau and Yunnan zone of southeast edge of Tibetan plateau, also discusses temporal variations of PFS orientations of 1999 Xiuyan earthquake sequences of northeastern China. The results are consistent to those of other independent traditional stress measurements. There is a bridge between crustal PFS and the crustal principal compressive stress although there are many unclear disturbance sources. This study suggests the PFS results could be used to deduce regional and in situ principal compressive stress in the crust only if there are enough seismic stations and enough data. At least, PFS is a useful choice in the zone where there are a large number of dense seismic stations.展开更多
Using seismic data recorded by Yunnan Telemetry Seismic Network from January 1, 2000 to December 31, 2003, the dominant polarization directions of fast shear-waves are obtained at 10 digital seismic stations by SAM te...Using seismic data recorded by Yunnan Telemetry Seismic Network from January 1, 2000 to December 31, 2003, the dominant polarization directions of fast shear-waves are obtained at 10 digital seismic stations by SAM technique, a systematic analysis method on shear-wave splitting, in this study. The results show that dominant directions of polarizations of fast shear-waves at most stations are mainly at nearly N-S or NNW direction in Yunnan. The dominant polarization directions of fast shear-waves at stations located on the active faults are consistent with the strike of active faults, directions of regional principal compressive strains measured from GPS data, and basically consistent with regional principal compressive stress. Only a few of stations.show complicated polarization pattern of fast shear-waves, or are not consistent with the strike of active faults and the directions of principal GPS compressive strains, which are always located at junction of several faults. The result reflects complicated fault distribution and stress field. The dominant polarization direction of fast shear-wave indicates the direction of the in-situ maximum principal compressive stress is controlled by multiple tectonic aspects such as the regional stress field and faults.展开更多
Based on a dynamic analysis method and an explicit algorithm,a dynamic explicit finite element code was developed for modeling the fast upsetting process of block under drop hammer impact,in which the hammer velocity ...Based on a dynamic analysis method and an explicit algorithm,a dynamic explicit finite element code was developed for modeling the fast upsetting process of block under drop hammer impact,in which the hammer velocity during the deformation was calculated by energy conservation law according to the operating principle of hammer equipment.The stress wave propagation and its effect on the deformation were analyzed by the stress and strain distributions.Industrial pure lead,oxygen-free high-conductivity (OFHC) copper and 7039 aluminum alloy were chosen to investigate the effect of material parameters on the stress wave propagation.The results show that the stress wave propagates from top to bottom of block,and then reflects back when it reaches the bottom surface.After that,stress wave propagates and reflects repeatedly between the upper surface and bottom surface.The stress wave propagation has a significant effect on the deformation at the initial stage,and then becomes weak at the middle-final stage.When the ratio of elastic modulus or the slope of stress-strain curve to mass density becomes larger,the velocity of stress wave propagation increases,and the influence of stress wave on the deformation becomes small.展开更多
基金Supported by 2022 Educational Research Program for Young and Middle-aged Teachers in Fujian Province(Science and Technology),No.JAT220107.
文摘BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.
基金supported by International Science and Technology Cooperation Program of China(2010DFB20190)National Natural Science Foundation of China(41040034 and 41174042)the support by basic research project of Institute of Earthquake Science,China Earthquake Administration(2009IES0211)
文摘When propagating through anisotropic rocks in the crust, shear-waves split into faster and slower components with almost orthogonal polarizations. For nearly vertical propagation the polarization of fast shear- wave （PFS） is parallel to both the strike of the cracks and the direction of maximum horizontal stress, therefore it is possible to use PFS to study stress in the crust. This study discusses several examples in which PFS is applied to deduce the compressive stress in North China, Longmenshan fault zone of east edge of Tibetan plateau and Yunnan zone of southeast edge of Tibetan plateau, also discusses temporal variations of PFS orientations of 1999 Xiuyan earthquake sequences of northeastern China. The results are consistent to those of other independent traditional stress measurements. There is a bridge between crustal PFS and the crustal principal compressive stress although there are many unclear disturbance sources. This study suggests the PFS results could be used to deduce regional and in situ principal compressive stress in the crust only if there are enough seismic stations and enough data. At least, PFS is a useful choice in the zone where there are a large number of dense seismic stations.
基金National Natural Science Foundation of China (40274011).
文摘Using seismic data recorded by Yunnan Telemetry Seismic Network from January 1, 2000 to December 31, 2003, the dominant polarization directions of fast shear-waves are obtained at 10 digital seismic stations by SAM technique, a systematic analysis method on shear-wave splitting, in this study. The results show that dominant directions of polarizations of fast shear-waves at most stations are mainly at nearly N-S or NNW direction in Yunnan. The dominant polarization directions of fast shear-waves at stations located on the active faults are consistent with the strike of active faults, directions of regional principal compressive strains measured from GPS data, and basically consistent with regional principal compressive stress. Only a few of stations.show complicated polarization pattern of fast shear-waves, or are not consistent with the strike of active faults and the directions of principal GPS compressive strains, which are always located at junction of several faults. The result reflects complicated fault distribution and stress field. The dominant polarization direction of fast shear-wave indicates the direction of the in-situ maximum principal compressive stress is controlled by multiple tectonic aspects such as the regional stress field and faults.
文摘Based on a dynamic analysis method and an explicit algorithm,a dynamic explicit finite element code was developed for modeling the fast upsetting process of block under drop hammer impact,in which the hammer velocity during the deformation was calculated by energy conservation law according to the operating principle of hammer equipment.The stress wave propagation and its effect on the deformation were analyzed by the stress and strain distributions.Industrial pure lead,oxygen-free high-conductivity (OFHC) copper and 7039 aluminum alloy were chosen to investigate the effect of material parameters on the stress wave propagation.The results show that the stress wave propagates from top to bottom of block,and then reflects back when it reaches the bottom surface.After that,stress wave propagates and reflects repeatedly between the upper surface and bottom surface.The stress wave propagation has a significant effect on the deformation at the initial stage,and then becomes weak at the middle-final stage.When the ratio of elastic modulus or the slope of stress-strain curve to mass density becomes larger,the velocity of stress wave propagation increases,and the influence of stress wave on the deformation becomes small.
