The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use e...The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.展开更多
A complex system is inherently high-dimensional.Recent studies indicate that,even without complete knowledge of its evolutionary dynamics,the future behavior of such a system can be predicted using time-series data(da...A complex system is inherently high-dimensional.Recent studies indicate that,even without complete knowledge of its evolutionary dynamics,the future behavior of such a system can be predicted using time-series data(data-driven prediction).This suggests that the essential dynamics of a complex system can be captured through a low-dimensional representation.Virus evolution and climate change are two examples of complex,time-varying systems.In this article,we show that mutations in the spike protein provide valuable data for predicting SARS-CoV-2 variants,forecasting the possible emergence of the new macro-lineage Q in the near future.Our analysis also demonstrates that carbon dioxide concentration is a reliable indicator for predicting the evolution of the climate system,extending global surface air temperature(GSAT)forecasts through 2500.展开更多
The Taklimakan Desert,located in the heart of central Asia,covers approximately 330000 km^(2),making it China's largest desert and the world's second-largest shifting desert(Dong et al.,2024).With an average a...The Taklimakan Desert,located in the heart of central Asia,covers approximately 330000 km^(2),making it China's largest desert and the world's second-largest shifting desert(Dong et al.,2024).With an average annual precipitation of less than 100 mm and evaporation rates ranging from 2000 to 3000 mm(Yang et al.,2020),it is recognized as one of the driest regions on Earth,often referred to as the“sea of death”.展开更多
Extensive flooding swept across large areas of Central Asia,mainly over Kazakhstan and southwestern Russia,from late March to April 2024.It was reported to be the worst flooding in the area in the past 70 years and ca...Extensive flooding swept across large areas of Central Asia,mainly over Kazakhstan and southwestern Russia,from late March to April 2024.It was reported to be the worst flooding in the area in the past 70 years and caused widespread devastation to society and infrastructure.However,the drivers of this record-breaking flood remain unexplored.Here,we show that the record-breaking floods were contributed by both long-term climate warming and interannual variability,with multiple climatic drivers at play across the synoptic to seasonal timescales.First,the heavy snowmelt in March 2024 was associated with above-normal preceding winter snow accumulation.Second,extreme rainfall was at a record-high during March 2024,in line with its increasing trend under climate warming.Third,the snowmelt and extreme rainfall in March were compounded by record-high soil moisture conditions in the preceding winter,which was a result of interannual variability and related to excessive winter rainfall over Central Asia.As climate warming continues,the interplay between the increasing trend of extreme rainfall,interannual variations in soil moisture pre-conditions,as well as shifting timing and magnitudes of spring snowmelt,will further increase and complicate spring flooding risks.This is a growing and widespread challenge for the mid-to high-latitude regions.展开更多
Tree growth synchrony serves as a valuable ecological indicator of forest resilience to climate stress and disturbances.However,our understanding of how increasing temperature affects tree growth synchrony during rapi...Tree growth synchrony serves as a valuable ecological indicator of forest resilience to climate stress and disturbances.However,our understanding of how increasing temperature affects tree growth synchrony during rapidly and slowly warming periods in ecosystems with varying climatic conditions remains limited.By using tree-ring data from temperate broadleaf(Fraxinus mandshurica,Phellodendron amurense,Quercus mongolica,and Juglans mandshurica)and Korean pine(Pinus koraiensis)mixed forests in northeast China,we investigated the effects of climate change,particularly warming,on the growth synchrony of five dominant temperate tree species across contrasting warm-dry and cool-wet climate conditions.Results show that temperature over water availability was the primary factor driving the growth and growth synchrony of the five species.Growth synchrony was significantly higher in warm-dry than in cool-wet areas,primarily due to more uniform climate conditions and higher climate sensitivity in the former.Rapid warming from the 1960s to the 1990s significantly enhanced tree growth synchrony in both areas,followed by a marked reversal as temperatures exceeded a certain threshold or warming slowed down,particularly in the warm-dry area.The growth synchrony variation patterns of the five species were highly consistent over time,although broadleaves exhibited higher synchrony than conifers,suggesting potential risks to forest resilience and stability under future climate change scenarios.Growing season temperatures and non-growing season temperatures and precipitation had a stronger positive effect on tree growth in the cool-wet area compared to the warm-dry area.High relative humidity hindered growth in the cool-wet area but enhanced it in the warm-dry area.Overall,our study highlights that the diversity and sensitivity of climate-growth relationships directly determine spatiotemporal growth synchrony.Temperature,along with water availability,shape long-term forest dynamics by affecting tree growth and synchrony.These results provide crucial insights for forest management practice to enhance structural diversity and resilience capacity against climate changeinduced synchrony shifts.展开更多
Central Asia,located in the innermost part of the Eurasian continent,has experienced“warming and humidification”in recent decades,with potentially important implications for tree growth in alpine forests,which are c...Central Asia,located in the innermost part of the Eurasian continent,has experienced“warming and humidification”in recent decades,with potentially important implications for tree growth in alpine forests,which are critical for regional water reserves.We use nested principal component analysis to assess tree radial growth patterns and reveal significant positive trends since the 20th century across Central Asian alpine forests(0.076 per decade during 1900-2021,p=0.003).Regional hydroclimatic variations affect the greening of these alpine forests,especially with extreme droughts being the most damaging.Growth acceleration is driven by low-latitude warming,which enhances regional temperatures and precipitation.The warming ocean centers alter atmospheric circulation patterns,leading to more moisture being transported to the Central Asian alpine forests,thereby increasing regional precipitation and promoting tree growth.Our model projections indicate that growth rates will continue to rise in the future.However,unprecedented warming may eventually lead to growth deterioration if negative effects,such as insufficient precipitation,occur due to breakdown signs of positive feedback mechanisms,such as moisture transport driven by low-latitude warming.Our study highlights the beneficial,but not unlimited,influences of climate warming on tree growth in Central Asian alpine forests,with implications for the sustainability of water resources.However,as urban and agricultural demands escalate,a holistic,long-term perspective is recommended to mitigate the adverse effects of temperature increases.展开更多
The change in interannual precipitation variability(P_(IAV)),especially the part driven by El Niño–Southern Oscillation over the Pacific,has sparked worldwide concern.However,it is plagued by substantial uncerta...The change in interannual precipitation variability(P_(IAV)),especially the part driven by El Niño–Southern Oscillation over the Pacific,has sparked worldwide concern.However,it is plagued by substantial uncertainty,such as model uncertainty,internal variability,and scenario uncertainty.Single-model initial-condition large ensembles(SMILEs)and a polynomial fitting method were suggested to separate these uncertainty sources.However,the applicability of a widely used polynomial fitting method in the uncertainty separation of P_(IAV)projection remains unknown.This study compares three sources of uncertainty estimated from five SMILEs and 28 models with one ensemble member in phase 6 of the Coupled Model Intercomparison Project(CMIP6).Results show that the internal uncertainty based on models with one ensemble member calculated using the polynomial fitting method is significantly underestimated compared to SMILEs.However,internal variability in CMIP6 as represented in the pre-industrial control run,aligns closely with SMILEs.At 1.5°C warming above the preindustrial level,internal variability dominates globally,masking the externally forced P_(IAV)signal.At 2.0°C warming,both internal and model uncertainties are significant over regions like Central Africa,the equatorial Indian Ocean,the Maritime Continent,and the Arctic,while internal variability still dominates elsewhere.In some regions,the forced signal becomes distinguishable from internal variability.This study reveals the limitations of the polynomial fitting method in separating P_(IAV)projection uncertainties and emphasizes the importance of SMILEs for accurately quantifying uncertainty sources.It also suggests that improving the intermodel agreement at warming levels of 1.5°C and 2.0°C will not substantially reduce uncertainty in most regions.展开更多
In August 2019,accompanied by an Arctic warming event,elevated thunderstorms crossed over the North Pole(NP)and produced lightning.The northernmost stroke occurred less than 50 km from the NP,marking the closest strok...In August 2019,accompanied by an Arctic warming event,elevated thunderstorms crossed over the North Pole(NP)and produced lightning.The northernmost stroke occurred less than 50 km from the NP,marking the closest stroke to the NP ever recorded.Using ERA5 reanalysis data and satellite observations,we investigated the background and development mechanism of this event.Warm and moist air from low latitudes was transported northward to the vicinity of the North Pole by the 850-h Pa jet,resulting in convergence.Through the combined effects of frontal lifting and the presence of underlying cold air,the warm and moist air was lifted to heights above the melting layer,triggering elevated thunderstorms above the frontal boundary.These findings describe a strong link between warming events and thunderstorms,revealing the formation mechanisms of elevated thunderstorms in the Arctic.In the context of rapid Arctic warming,this study provides preliminary insights into the meteorological conditions conducive to thunderstorm formation in the region.展开更多
There is a widespread policy assumption that anthropogenic greenhouse gases are the main driver of the observed 1°C rise in global surface air temperatures since‘pre-industrial’times.This paper demonstrates tha...There is a widespread policy assumption that anthropogenic greenhouse gases are the main driver of the observed 1°C rise in global surface air temperatures since‘pre-industrial’times.This paper demonstrates that the onset of the current warming trend began in the mid-19th century and is consistent with the rising phase of variable global warming and cooling cycles in both the Northern and Southern Hemispheres.Hemispheres.The last trough of the millennial cycle,the Little Ice Age,coincides approximately with the baseline of pre-industrial times used to calculate the impact of Anthropogenic Global Warming.Yet,half of the observed 20th century temperature rise occurred before 1950 when carbon dioxide levels remained low,with the remaining half happening at a similar rate of warming despite the much higher concentrations of greenhouse gases in the atmosphere.This study shows that when the amplitudes and rates of change of the long-term global cycles are considered,the anthropogenic component of warming can be reduced to 38%(using factors derived from the latest IPCC Working Group reports)to as little as 25%(using observational flux data of dominant Short Wave Absorbed Surface Radiation).These global climate cycles can be extrapolated into the future and the implications for policy of a large natural component to climate change are explored—in particular,the potential for mitigation strategies to have minimal impact and for the climate to cool consequent upon a cyclic down-phase.展开更多
The intensification of extreme precipitation(EP)under global warming presents a substantial risk to human safety and societal progress.Studying the specific impacts of global warming on rare EP events in China not onl...The intensification of extreme precipitation(EP)under global warming presents a substantial risk to human safety and societal progress.Studying the specific impacts of global warming on rare EP events in China not only enhances the comprehension of these shifts,but also paves the way for the development of proactive strategies to alleviate associated damages.Results from large-ensemble simulation data demonstrate that global warming has led to an enhancement in once-in-a-decade EP events in parts of western and central China over the past few decades,with the strengthening of the South Asia high(SAH)caused by global warming playing a dominant role.The strengthening of the SAH corresponds to an intensification and westward extension of the western Pacific subtropical high in the lower troposphere.The region between these two systems experiences enhanced upward motion and increased southwesterly water vapor transport,leading to a rise in climatological precipitation in western and central China,thereby raising the threshold for once-in-a-decade EP events.展开更多
The onset,cessation,and length of the rainy season are crucial for global water resources,agricultural practices,and food security.However,the response of precipitation seasonality to global warming remains uncertain....The onset,cessation,and length of the rainy season are crucial for global water resources,agricultural practices,and food security.However,the response of precipitation seasonality to global warming remains uncertain.In this study,we analyze how global warming levels(GWLs)of 1.5℃ and 2℃ could affect the timing of rainfall onset(RODs),rainfall cessation(RCDs),and the overall duration of the rainy season(LRS)over global land monsoon(GLM)regions using simulations from CMIP6 under the SSP2-4.5 and SSP5-8.5 scenarios.With high model consensus,our results reveal that RODs are projected to occur later over Southern Africa,North Africa,and South America,but earlier over South Asia and Australia,in a warmer climate.The projected early RODs in Australia are more pronounced at the 2℃ GWL under SSP5-8.5.On the other hand,early RCDs are projected over South America and East Asia,while late RCDs are projected over North Africa,with high inter-model agreement.These changes are associated with a future decrease in LRS in most GLM regions.Additionally,we found that continuous warming over 1.5℃ will further reduce the length of the rainy season,especially over the South America,North Africa,and Southern Africa monsoon regions.The findings underscore the urgent need to mitigate global warming.展开更多
The dependence of energy metabolism on temperature is universally recognized as a critical physiological hallmark for evaluating the susceptibility of ectothermic organisms to global warming.However,the underlying phy...The dependence of energy metabolism on temperature is universally recognized as a critical physiological hallmark for evaluating the susceptibility of ectothermic organisms to global warming.However,the underlying physiological and biochemical bases of this temperature dependence remain largely unknown.In this study,we conducted a simulated climate warming experiment under seminatural enclosure conditions and compared the differences in resting metabolic rate (RMR) and key metabolic enzyme activities between the warming and control groups of Takydromus septentrionalis at various test temperatures.We found that the activities of hexokinase,lactate dehydrogenase,alanine aminotransferase and acetyl-CoA carboxylase of T.septentrionalis were not affected by climate warming,despite a decrease in RMR measured at high temperatures of 34°C and 38°C.Overall,these findings suggest that artificial warming simulating climate change can lead to a decline in RMR,but does not alter the activity of key metabolic enzymes.Our study provides insight into how climate warming influences the energy metabolism of lizards.展开更多
Global warming and nitrogen(N)deposition have a profound impact on greenhouse gas(GHG)fluxes and consequently,they also affect climate change.However,the global combined effects of warming and N addition on GHG fluxes...Global warming and nitrogen(N)deposition have a profound impact on greenhouse gas(GHG)fluxes and consequently,they also affect climate change.However,the global combined effects of warming and N addition on GHG fluxes remain to be fully understood.To address this knowledge gap,a globalmeta-analysis of 197 datasets was performed to assess the response of GHG fluxes to warming and N addition and their interactions under various climate and experimental conditions.The results indicate that warming significantly increased CO_(2)emissions,while N addition and the combined warming and N addition treatments had no impact on CO_(2)emissions.Moreover,both warming and N addition and their interactions exhibited positive effects on N_(2)O emissions.Under the combined warming and N addition treatments,warming was observed to exert a positive main effect on CO_(2)emissions,while N addition had a positive main effect on N_(2)O emissions.The interactive effects of warming and N addition exhibited antagonistic effects on CO_(2),N_(2)O,and CH_(4)emissions,with CH_(4)uptake dominated by additive effects.Furthermore,we identified biome and climate factors as the two treatments.These findings indicate that both warming and N addition substantially impact soil GHG fluxes and highlight the urgent need to investigate the influence of the combination of warming and N addition on terrestrial carbon and N cycling under ongoing global change.展开更多
Climate change is a natural phenomenon.Over the past billions of years,Earth’s climate has experienced many ice and warm periods.These changes have created various environments,directly benefiting and disadvantaging ...Climate change is a natural phenomenon.Over the past billions of years,Earth’s climate has experienced many ice and warm periods.These changes have created various environments,directly benefiting and disadvantaging certain species,eventually leding to extinction and evolutionary diversification through natural selection.However,rapid and drastic changes in Earth’s climate could be destructive and may lead to mass extinction.It is generally believed that four of the five mass extinction events were caused by drastic changes in the level of atmospheric greenhouse gases.In the recent period(the Anthropocene epoch),when human activi-ties began to significantly impact the Earth’s climate,numerous pieces of scientific evidence indicate that anthropogenic activities are associated with the extinction of plants and animals and may lead to the sixth mass extinction.However,some scientists deny the pos-sibility of the 6th mass extinction.Therefore,there is an urgent need to comprehensively review the impact of anthropogenic global warming on our natural environment.This article reviews the scientific evidence of the synergistic impact and chain effects of anthro-pogenic global warming on ecosystems and living organisms on Earth.It earnestly attempts to summarize relevant data published for specific research questions to improve the understanding of diverse evidence.This helps clarify the current state of research and rai-ses public awareness of the impact of anthropogenic global warming on all stakeholders on Earth.展开更多
Grazing management significantly influences greenhouse gas(GHG)emissions and the global warming potential(GWP)in grasslands.Yet,a limited understanding of the impact of grazing and grazing exclusion on GHG emis-sions ...Grazing management significantly influences greenhouse gas(GHG)emissions and the global warming potential(GWP)in grasslands.Yet,a limited understanding of the impact of grazing and grazing exclusion on GHG emis-sions and GWP in grasslands hinders progress towards grassland ecosystem sustainability and GHG mitigation.We conducted a global meta-analysis of 75 published studies to investigate the effects of grazing and grazing exclusion on methane(CH_(4)),carbon dioxide(CO_(2)),nitrous oxide(N_(2 )O),and GWP.Our results revealed that grazing and grazing exclusion significantly increased the CO_(2) and CH4 emissions,respectively.The responses of GHG emissions and GWP to grazing were regulated by grazing intensity and elevation.We also found that light grazing significantly decreased GWP but heavy grazing increased GWP.Reducing grazing intensity was a simple and effective method through stocking rate adjustment,which promised a large GHG mitigation poten-tial.Our results demonstrated that GHG emissions increased with elevation under grassland grazing,implying that irrational grazing in high-elevation grasslands promoted GHG emissions.In comparison with grazing,only long-term grazing exclusion reduced the GWP,and CH4 emissions enhanced with grazing exclusion duration.However,long-term grazing exclusion may shift economic demand and grazing burden to other areas.Overall,we suggested that regulating the grazing intensity,rather than grazing exclusion,was an effective way to re-duce GHG emissions.Our study contributed to the enhancement of sustainable grazing management practices for GHG balance and GWP in global grasslands,and offered a global picture for understanding the changes in GHG emissions and GWP under different grazing management regimes.展开更多
Global warming is primarily characterized by asymmetric temperature increases,with greater temperature rises in winter/spring and at night compared to summer/autumn and the daytime.We investigated the impact of winter...Global warming is primarily characterized by asymmetric temperature increases,with greater temperature rises in winter/spring and at night compared to summer/autumn and the daytime.We investigated the impact of winter night warming on the top expanded leaves of the spring wheat cultivar Yangmai 18 and the semi-winter wheat cultivar Yannong 19 during the 2020-2021 growing season.Results showed that the night-time mean temperature in the treatment group was 1.27°C higher than the ambient temperature,and winter night warming increased the yields of both wheat cultivars,the activities of sucrose synthase and sucrose phosphate synthase after anthesis,and the biosynthesis of sucrose and soluble sugars.Differentially expressed genes(DEGs)were identified using criteria of P-value<0.05 and fold change>2,and they were subjected to Gene Ontology(GO)annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses.Genes differentially expressed in wheat leaves treated with night warming were primarily associated with starch and sucrose metabolism,amino acid biosynthesis,carbon metabolism,plant hormone signal transduction,and amino sugar and nucleotide sugar metabolism.Comparisons between the groups identified 14 DEGs related to temperature.These results highlight the effects of winter night warming on wheat development from various perspectives.Our results provide new insights into the molecular mechanisms of the response of wheat to winter night warming and the candidate genes involved in this process.展开更多
Recent studies identify large uncertainties in the projections of tropical cyclone(TC)activity due to discrepancies in tropical Pacific sea surface temperature(SST)warming patterns.While observational datasets consist...Recent studies identify large uncertainties in the projections of tropical cyclone(TC)activity due to discrepancies in tropical Pacific sea surface temperature(SST)warming patterns.While observational datasets consistently reveal a La Niña-like warming pattern[0.15℃-0.25℃(10 yr)^(−1) relative cooling in the eastern equatorial Pacific],over 80%of CMIP6 models project an erroneous El Niño-like trend.These discrepancies arise from biases in cloud feedbacks,Walker circulation strength,and oceanic upwelling processes.This review examines the key mechanisms shaping observed versus modeled warming patterns,evaluates the complex link between tropical SST patterns and TC activity,and explores the feasibility of storm-resolving models for improving TC projections.We propose that pattern-conditioned TC projections using convection-permitting models,alongside physics-informed interpretations,offer a path forward in reducing uncertainties in future climate predictions.展开更多
EC-Earth3P-HR reproduces well the observed Boreal Summer Intraseasonal Oscillation(BSISO)and its impacts on tropical cyclone genesis(TCG)in the western North Pacific(WNP).Hence,the historical simulation(1950-1979)and ...EC-Earth3P-HR reproduces well the observed Boreal Summer Intraseasonal Oscillation(BSISO)and its impacts on tropical cyclone genesis(TCG)in the western North Pacific(WNP).Hence,the historical simulation(1950-1979)and future projection under the SSP5-8.5 scenario(2020-2049)in EC-Earth3P-HR are adopted to explore possible changes in the BSISO’s modification of WNP TCG under global warming to enhance the understanding of TC activities in the WNP.Results show that the BSISO circulation in the WNP shifts northeastward under global warming.This leads to enhanced convection in a northwest-southeast-oriented band crossing the WNP.Along the band,the BSISO-related TCG anomalies are enhanced.Analyses of genesis potential index show that changes in the BSISO-related mid-tropospheric relative humidity play the dominant role in modifying the BSISO’s impacts on WNP TCG under global warming.The enhanced BSISO convection in the band moistens the middle troposphere,which helps reduce the entrainment of generally dry mid-tropospheric air in the updrafts and the modification of the boundary layer by the downdraft of generally dry mid-tropospheric air,leading to enhanced TCG.展开更多
BACKGROUND There is a lack of integrated Chinese and Western medicine treatment regimens supported by high-level evidence-based medicine in the maintenance therapy phase of metastatic colorectal cancer(mCRC).Based on ...BACKGROUND There is a lack of integrated Chinese and Western medicine treatment regimens supported by high-level evidence-based medicine in the maintenance therapy phase of metastatic colorectal cancer(mCRC).Based on the traditional Chinese medicine theory of“Yin tumor”,we believe that“Yang does not transform Yin,and it is blocked in the intestines”is the core pathogenesis of mCRC.Based on the basic treatment principle of“warming Yang and dredging intestines”,we developed the Quxie Capsule.Previous randomized controlled clinical trials demonstrated that the Quxie Capsule can significantly prolong the overall survival of patients with mCRC,but it remains to be verified whether the combination of the“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong the efficacy and safety of the mCRC during the period of maintenance therapy.AIM To confirm and clinically validate that the combination of“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong progression-free survival(PFS)during maintenance treatment of mCRC.The safety of“warming Yang and dredging intestines method”prescription is also assessed.METHODS The study has a prospective,open-label,randomized,controlled study design.Patients have been recruited beginning November 2023 from Xiyuan Hospital of China Academy of Chinese Medical Sciences,Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Dongfang Hospital of Beijing University of Chinese Medicine,and Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine.The study period is from March 2024 to March 2026.After screening in outpatient clinics or wards,subjects who met the inclusion criteria are randomized into the treatment or control group in a 2:1 ratio.The treatment group receives the“warming Yang and dredging intestines method”formula combined with Western standard maintenance therapy.The control group receives Western standard maintenance therapy formulated by the investigators based on the Chinese Society of Clinical Oncology guidelines for colorectal cancer.All participants receive treatment until the occurrence of disease progression,death,or unmanageable adverse effects,with post-treatment monitoring continued until mortality.An independent panel of chief physicians with extensive clinical experience evaluates the progression of the disease.RESULTS This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.The goal is to provide a combined Chinese and Western medicine treatment option for clinical physicians and mCRC patients.Notably,with the actual sample size,this study has an 80%probability of detecting a significant difference if a true difference exists.Small sample sizes may lead to increased instability of the results of subgroup analyses,and may also result in findings that are only applicable to patients with characteristics highly similar to those of the present study population(e.g.,specific genotypes,therapeutic backgrounds,etc.),making it difficult to generalize to the broader mCRC population.In the future,it may be possible to expand the sample size based on this study to further validate the efficacy and safety of combining Chinese and Western medicine in the treatment of mCRC.Basic research on the therapeutic combination of warming Yang and dredging intestines method formula and standard Western regimen will be performed in parallel.CONCLUSION This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.展开更多
Global warming has been reported to enhance thermal stratification and decrease the mixlayer depth(MLD)in waters due to higher surface water temperatures,especially in summer.Previous studies were conducted for indivi...Global warming has been reported to enhance thermal stratification and decrease the mixlayer depth(MLD)in waters due to higher surface water temperatures,especially in summer.Previous studies were conducted for individual cases or specific periods.At present,there is a lack of global assessments on the influence of climate warming in different seasons on thermal stratification.The ECMWF Reanalysis v5(ERA5)dataset was used to estimate the variability of water body mixing and its drivers in different seasons and regions.Results indicate that global warming could enhance thermal stratification and decrease the MLD globally in summer.Wind speed was the primary driver of MLD changes,followed by temperature.However,ice melt due to global warming enhanced the mixing in icecovered waters in the Northern Hemisphere,and early ice melt led to early mixing.Ice depth was the primary driver of MLD changes in the Northern Hemisphere due to delayed ice formation and earlier melting,while wind speed was the primary driver in other regions or during ice-free seasons.The enhanced mixing due to earlier ice melt out in late winter and early spring could promote water circulation and nutrient turnover,and replenish dissolved oxygen in deep water,thereby promoting the maximum biomass of cyanobacteria and advance harmful algal blooms.展开更多
基金supported by the Natural Science Fund of China(31771724)the Key Research and Development Project of Shaanxi Province(2024NC-ZDCYL-01-10).
文摘The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.
基金Natural science foundation of Inner Mongolia(2024LHMS06018)The basic scientific research funding for directly affiliated universities in the Inner Mongolia(JY20250094)。
文摘A complex system is inherently high-dimensional.Recent studies indicate that,even without complete knowledge of its evolutionary dynamics,the future behavior of such a system can be predicted using time-series data(data-driven prediction).This suggests that the essential dynamics of a complex system can be captured through a low-dimensional representation.Virus evolution and climate change are two examples of complex,time-varying systems.In this article,we show that mutations in the spike protein provide valuable data for predicting SARS-CoV-2 variants,forecasting the possible emergence of the new macro-lineage Q in the near future.Our analysis also demonstrates that carbon dioxide concentration is a reliable indicator for predicting the evolution of the climate system,extending global surface air temperature(GSAT)forecasts through 2500.
基金supported by the National Natural Science Foundation of China(No.42072211)the National Natural Science Foundation of China(No.42401048)the Third Xinjiang Scientific Expedition and Research Program(No.2021xjkk0302)。
文摘The Taklimakan Desert,located in the heart of central Asia,covers approximately 330000 km^(2),making it China's largest desert and the world's second-largest shifting desert(Dong et al.,2024).With an average annual precipitation of less than 100 mm and evaporation rates ranging from 2000 to 3000 mm(Yang et al.,2020),it is recognized as one of the driest regions on Earth,often referred to as the“sea of death”.
基金jointly supported by the National Natural Science Foundation of China(Grant Nos.42422502,42275038)the China Meteorological Administration Climate Change Special Program(Grant No.QBZ202306)。
文摘Extensive flooding swept across large areas of Central Asia,mainly over Kazakhstan and southwestern Russia,from late March to April 2024.It was reported to be the worst flooding in the area in the past 70 years and caused widespread devastation to society and infrastructure.However,the drivers of this record-breaking flood remain unexplored.Here,we show that the record-breaking floods were contributed by both long-term climate warming and interannual variability,with multiple climatic drivers at play across the synoptic to seasonal timescales.First,the heavy snowmelt in March 2024 was associated with above-normal preceding winter snow accumulation.Second,extreme rainfall was at a record-high during March 2024,in line with its increasing trend under climate warming.Third,the snowmelt and extreme rainfall in March were compounded by record-high soil moisture conditions in the preceding winter,which was a result of interannual variability and related to excessive winter rainfall over Central Asia.As climate warming continues,the interplay between the increasing trend of extreme rainfall,interannual variations in soil moisture pre-conditions,as well as shifting timing and magnitudes of spring snowmelt,will further increase and complicate spring flooding risks.This is a growing and widespread challenge for the mid-to high-latitude regions.
基金supported by the National Natural Science Foundation of China(Nos.42107476 and 42177421)the China Postdoctoral International Exchange Fellowship Program(No.PC2021099)+1 种基金the Science and Technology Innovation Program of Hunan Province(No.2020RC2058)the China Scholarship Council(CSC,No.202206600004,to D.Yuan).
文摘Tree growth synchrony serves as a valuable ecological indicator of forest resilience to climate stress and disturbances.However,our understanding of how increasing temperature affects tree growth synchrony during rapidly and slowly warming periods in ecosystems with varying climatic conditions remains limited.By using tree-ring data from temperate broadleaf(Fraxinus mandshurica,Phellodendron amurense,Quercus mongolica,and Juglans mandshurica)and Korean pine(Pinus koraiensis)mixed forests in northeast China,we investigated the effects of climate change,particularly warming,on the growth synchrony of five dominant temperate tree species across contrasting warm-dry and cool-wet climate conditions.Results show that temperature over water availability was the primary factor driving the growth and growth synchrony of the five species.Growth synchrony was significantly higher in warm-dry than in cool-wet areas,primarily due to more uniform climate conditions and higher climate sensitivity in the former.Rapid warming from the 1960s to the 1990s significantly enhanced tree growth synchrony in both areas,followed by a marked reversal as temperatures exceeded a certain threshold or warming slowed down,particularly in the warm-dry area.The growth synchrony variation patterns of the five species were highly consistent over time,although broadleaves exhibited higher synchrony than conifers,suggesting potential risks to forest resilience and stability under future climate change scenarios.Growing season temperatures and non-growing season temperatures and precipitation had a stronger positive effect on tree growth in the cool-wet area compared to the warm-dry area.High relative humidity hindered growth in the cool-wet area but enhanced it in the warm-dry area.Overall,our study highlights that the diversity and sensitivity of climate-growth relationships directly determine spatiotemporal growth synchrony.Temperature,along with water availability,shape long-term forest dynamics by affecting tree growth and synchrony.These results provide crucial insights for forest management practice to enhance structural diversity and resilience capacity against climate changeinduced synchrony shifts.
基金supported by Excellent Research Group Program for Tibetan Plateau Earth System(continuation grant NSFC project No.41988101)the National Natural Science Foundation of China(Nos.U1803341 and 32061123008)+1 种基金the National Key R&D Program of China(No.2018YFA0606401)the National Youth Talent Support Program.
文摘Central Asia,located in the innermost part of the Eurasian continent,has experienced“warming and humidification”in recent decades,with potentially important implications for tree growth in alpine forests,which are critical for regional water reserves.We use nested principal component analysis to assess tree radial growth patterns and reveal significant positive trends since the 20th century across Central Asian alpine forests(0.076 per decade during 1900-2021,p=0.003).Regional hydroclimatic variations affect the greening of these alpine forests,especially with extreme droughts being the most damaging.Growth acceleration is driven by low-latitude warming,which enhances regional temperatures and precipitation.The warming ocean centers alter atmospheric circulation patterns,leading to more moisture being transported to the Central Asian alpine forests,thereby increasing regional precipitation and promoting tree growth.Our model projections indicate that growth rates will continue to rise in the future.However,unprecedented warming may eventually lead to growth deterioration if negative effects,such as insufficient precipitation,occur due to breakdown signs of positive feedback mechanisms,such as moisture transport driven by low-latitude warming.Our study highlights the beneficial,but not unlimited,influences of climate warming on tree growth in Central Asian alpine forests,with implications for the sustainability of water resources.However,as urban and agricultural demands escalate,a holistic,long-term perspective is recommended to mitigate the adverse effects of temperature increases.
基金funded by the National Natural Science Foundation of China(Grant No.42425504).
文摘The change in interannual precipitation variability(P_(IAV)),especially the part driven by El Niño–Southern Oscillation over the Pacific,has sparked worldwide concern.However,it is plagued by substantial uncertainty,such as model uncertainty,internal variability,and scenario uncertainty.Single-model initial-condition large ensembles(SMILEs)and a polynomial fitting method were suggested to separate these uncertainty sources.However,the applicability of a widely used polynomial fitting method in the uncertainty separation of P_(IAV)projection remains unknown.This study compares three sources of uncertainty estimated from five SMILEs and 28 models with one ensemble member in phase 6 of the Coupled Model Intercomparison Project(CMIP6).Results show that the internal uncertainty based on models with one ensemble member calculated using the polynomial fitting method is significantly underestimated compared to SMILEs.However,internal variability in CMIP6 as represented in the pre-industrial control run,aligns closely with SMILEs.At 1.5°C warming above the preindustrial level,internal variability dominates globally,masking the externally forced P_(IAV)signal.At 2.0°C warming,both internal and model uncertainties are significant over regions like Central Africa,the equatorial Indian Ocean,the Maritime Continent,and the Arctic,while internal variability still dominates elsewhere.In some regions,the forced signal becomes distinguishable from internal variability.This study reveals the limitations of the polynomial fitting method in separating P_(IAV)projection uncertainties and emphasizes the importance of SMILEs for accurately quantifying uncertainty sources.It also suggests that improving the intermodel agreement at warming levels of 1.5°C and 2.0°C will not substantially reduce uncertainty in most regions.
基金supported by the National Key Research and Development Program of China(2023YFC3007703)National Natural Science Foundation of China(Grant Nos.41675066,42394122)+1 种基金CAS Project of Stable Support for Youth Team in Basic Research Field(YSRR-018)the Chinese Meridian Project。
文摘In August 2019,accompanied by an Arctic warming event,elevated thunderstorms crossed over the North Pole(NP)and produced lightning.The northernmost stroke occurred less than 50 km from the NP,marking the closest stroke to the NP ever recorded.Using ERA5 reanalysis data and satellite observations,we investigated the background and development mechanism of this event.Warm and moist air from low latitudes was transported northward to the vicinity of the North Pole by the 850-h Pa jet,resulting in convergence.Through the combined effects of frontal lifting and the presence of underlying cold air,the warm and moist air was lifted to heights above the melting layer,triggering elevated thunderstorms above the frontal boundary.These findings describe a strong link between warming events and thunderstorms,revealing the formation mechanisms of elevated thunderstorms in the Arctic.In the context of rapid Arctic warming,this study provides preliminary insights into the meteorological conditions conducive to thunderstorm formation in the region.
文摘There is a widespread policy assumption that anthropogenic greenhouse gases are the main driver of the observed 1°C rise in global surface air temperatures since‘pre-industrial’times.This paper demonstrates that the onset of the current warming trend began in the mid-19th century and is consistent with the rising phase of variable global warming and cooling cycles in both the Northern and Southern Hemispheres.Hemispheres.The last trough of the millennial cycle,the Little Ice Age,coincides approximately with the baseline of pre-industrial times used to calculate the impact of Anthropogenic Global Warming.Yet,half of the observed 20th century temperature rise occurred before 1950 when carbon dioxide levels remained low,with the remaining half happening at a similar rate of warming despite the much higher concentrations of greenhouse gases in the atmosphere.This study shows that when the amplitudes and rates of change of the long-term global cycles are considered,the anthropogenic component of warming can be reduced to 38%(using factors derived from the latest IPCC Working Group reports)to as little as 25%(using observational flux data of dominant Short Wave Absorbed Surface Radiation).These global climate cycles can be extrapolated into the future and the implications for policy of a large natural component to climate change are explored—in particular,the potential for mitigation strategies to have minimal impact and for the climate to cool consequent upon a cyclic down-phase.
基金supported by the National Natural Science Foundation of China[grant number 42088101]the National Key Research and Development Program of China[grant number 2022YFF0801702]。
文摘The intensification of extreme precipitation(EP)under global warming presents a substantial risk to human safety and societal progress.Studying the specific impacts of global warming on rare EP events in China not only enhances the comprehension of these shifts,but also paves the way for the development of proactive strategies to alleviate associated damages.Results from large-ensemble simulation data demonstrate that global warming has led to an enhancement in once-in-a-decade EP events in parts of western and central China over the past few decades,with the strengthening of the South Asia high(SAH)caused by global warming playing a dominant role.The strengthening of the SAH corresponds to an intensification and westward extension of the western Pacific subtropical high in the lower troposphere.The region between these two systems experiences enhanced upward motion and increased southwesterly water vapor transport,leading to a rise in climatological precipitation in western and central China,thereby raising the threshold for once-in-a-decade EP events.
基金supported by the Australian Research Council(Grant No.CE230100012)。
文摘The onset,cessation,and length of the rainy season are crucial for global water resources,agricultural practices,and food security.However,the response of precipitation seasonality to global warming remains uncertain.In this study,we analyze how global warming levels(GWLs)of 1.5℃ and 2℃ could affect the timing of rainfall onset(RODs),rainfall cessation(RCDs),and the overall duration of the rainy season(LRS)over global land monsoon(GLM)regions using simulations from CMIP6 under the SSP2-4.5 and SSP5-8.5 scenarios.With high model consensus,our results reveal that RODs are projected to occur later over Southern Africa,North Africa,and South America,but earlier over South Asia and Australia,in a warmer climate.The projected early RODs in Australia are more pronounced at the 2℃ GWL under SSP5-8.5.On the other hand,early RCDs are projected over South America and East Asia,while late RCDs are projected over North Africa,with high inter-model agreement.These changes are associated with a future decrease in LRS in most GLM regions.Additionally,we found that continuous warming over 1.5℃ will further reduce the length of the rainy season,especially over the South America,North Africa,and Southern Africa monsoon regions.The findings underscore the urgent need to mitigate global warming.
基金supported by the National Natural Science Foundation of China (Grant Nos.32330067,31971419,32311530110,and 32171486)。
文摘The dependence of energy metabolism on temperature is universally recognized as a critical physiological hallmark for evaluating the susceptibility of ectothermic organisms to global warming.However,the underlying physiological and biochemical bases of this temperature dependence remain largely unknown.In this study,we conducted a simulated climate warming experiment under seminatural enclosure conditions and compared the differences in resting metabolic rate (RMR) and key metabolic enzyme activities between the warming and control groups of Takydromus septentrionalis at various test temperatures.We found that the activities of hexokinase,lactate dehydrogenase,alanine aminotransferase and acetyl-CoA carboxylase of T.septentrionalis were not affected by climate warming,despite a decrease in RMR measured at high temperatures of 34°C and 38°C.Overall,these findings suggest that artificial warming simulating climate change can lead to a decline in RMR,but does not alter the activity of key metabolic enzymes.Our study provides insight into how climate warming influences the energy metabolism of lizards.
基金supported by Ningxia Key Research and Development Fund Project of China(No.2023BCF01048)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2023-JC-YB-182).
文摘Global warming and nitrogen(N)deposition have a profound impact on greenhouse gas(GHG)fluxes and consequently,they also affect climate change.However,the global combined effects of warming and N addition on GHG fluxes remain to be fully understood.To address this knowledge gap,a globalmeta-analysis of 197 datasets was performed to assess the response of GHG fluxes to warming and N addition and their interactions under various climate and experimental conditions.The results indicate that warming significantly increased CO_(2)emissions,while N addition and the combined warming and N addition treatments had no impact on CO_(2)emissions.Moreover,both warming and N addition and their interactions exhibited positive effects on N_(2)O emissions.Under the combined warming and N addition treatments,warming was observed to exert a positive main effect on CO_(2)emissions,while N addition had a positive main effect on N_(2)O emissions.The interactive effects of warming and N addition exhibited antagonistic effects on CO_(2),N_(2)O,and CH_(4)emissions,with CH_(4)uptake dominated by additive effects.Furthermore,we identified biome and climate factors as the two treatments.These findings indicate that both warming and N addition substantially impact soil GHG fluxes and highlight the urgent need to investigate the influence of the combination of warming and N addition on terrestrial carbon and N cycling under ongoing global change.
基金supported by the Scientific Research Capacity Building Project for Beibu Gulf Marine Ecological Environment Field Observation and Research Station of Guangxi(No.23-026-271)the Key Research Base of Humanities and Social Sciences in Guangxi Universities‘Beibu Gulf Ocean Development Research Center’the Pinglu Canal and Beibu Gulf Coastal Ecosystem Observation and Research Station of Guangxi.
文摘Climate change is a natural phenomenon.Over the past billions of years,Earth’s climate has experienced many ice and warm periods.These changes have created various environments,directly benefiting and disadvantaging certain species,eventually leding to extinction and evolutionary diversification through natural selection.However,rapid and drastic changes in Earth’s climate could be destructive and may lead to mass extinction.It is generally believed that four of the five mass extinction events were caused by drastic changes in the level of atmospheric greenhouse gases.In the recent period(the Anthropocene epoch),when human activi-ties began to significantly impact the Earth’s climate,numerous pieces of scientific evidence indicate that anthropogenic activities are associated with the extinction of plants and animals and may lead to the sixth mass extinction.However,some scientists deny the pos-sibility of the 6th mass extinction.Therefore,there is an urgent need to comprehensively review the impact of anthropogenic global warming on our natural environment.This article reviews the scientific evidence of the synergistic impact and chain effects of anthro-pogenic global warming on ecosystems and living organisms on Earth.It earnestly attempts to summarize relevant data published for specific research questions to improve the understanding of diverse evidence.This helps clarify the current state of research and rai-ses public awareness of the impact of anthropogenic global warming on all stakeholders on Earth.
基金supported by National Natural Science Foundation of China(Grant No.72394401).
文摘Grazing management significantly influences greenhouse gas(GHG)emissions and the global warming potential(GWP)in grasslands.Yet,a limited understanding of the impact of grazing and grazing exclusion on GHG emis-sions and GWP in grasslands hinders progress towards grassland ecosystem sustainability and GHG mitigation.We conducted a global meta-analysis of 75 published studies to investigate the effects of grazing and grazing exclusion on methane(CH_(4)),carbon dioxide(CO_(2)),nitrous oxide(N_(2 )O),and GWP.Our results revealed that grazing and grazing exclusion significantly increased the CO_(2) and CH4 emissions,respectively.The responses of GHG emissions and GWP to grazing were regulated by grazing intensity and elevation.We also found that light grazing significantly decreased GWP but heavy grazing increased GWP.Reducing grazing intensity was a simple and effective method through stocking rate adjustment,which promised a large GHG mitigation poten-tial.Our results demonstrated that GHG emissions increased with elevation under grassland grazing,implying that irrational grazing in high-elevation grasslands promoted GHG emissions.In comparison with grazing,only long-term grazing exclusion reduced the GWP,and CH4 emissions enhanced with grazing exclusion duration.However,long-term grazing exclusion may shift economic demand and grazing burden to other areas.Overall,we suggested that regulating the grazing intensity,rather than grazing exclusion,was an effective way to re-duce GHG emissions.Our study contributed to the enhancement of sustainable grazing management practices for GHG balance and GWP in global grasslands,and offered a global picture for understanding the changes in GHG emissions and GWP under different grazing management regimes.
基金supported by the Natural Science Foundation of Anhui Province,China(2008085qc118)the National Natural Science Foundation of China(U19A2021)+1 种基金the Major Science and Technology Special Project of Anhui Province,China(S202003a06020035)the Jiangsu Collaborative Innovation Center for Modern Crop Production,China(JCIC-MCP)。
文摘Global warming is primarily characterized by asymmetric temperature increases,with greater temperature rises in winter/spring and at night compared to summer/autumn and the daytime.We investigated the impact of winter night warming on the top expanded leaves of the spring wheat cultivar Yangmai 18 and the semi-winter wheat cultivar Yannong 19 during the 2020-2021 growing season.Results showed that the night-time mean temperature in the treatment group was 1.27°C higher than the ambient temperature,and winter night warming increased the yields of both wheat cultivars,the activities of sucrose synthase and sucrose phosphate synthase after anthesis,and the biosynthesis of sucrose and soluble sugars.Differentially expressed genes(DEGs)were identified using criteria of P-value<0.05 and fold change>2,and they were subjected to Gene Ontology(GO)annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses.Genes differentially expressed in wheat leaves treated with night warming were primarily associated with starch and sucrose metabolism,amino acid biosynthesis,carbon metabolism,plant hormone signal transduction,and amino sugar and nucleotide sugar metabolism.Comparisons between the groups identified 14 DEGs related to temperature.These results highlight the effects of winter night warming on wheat development from various perspectives.Our results provide new insights into the molecular mechanisms of the response of wheat to winter night warming and the candidate genes involved in this process.
基金supported partly by the AORI visiting professorship programsupported in part by a Moonshot R&D grant(Grant No.JPMJMS2282-02)from the Japan Science and Technology Agency+1 种基金the JSPS Core-to-Core Program,“International Core-to-Core Project on Global Storm Resolving Analysis”(Grant No.JPJSCCA20220001)JSPS KAKENHI(Grant Nos.20B202,20H05728,and 24K00703)。
文摘Recent studies identify large uncertainties in the projections of tropical cyclone(TC)activity due to discrepancies in tropical Pacific sea surface temperature(SST)warming patterns.While observational datasets consistently reveal a La Niña-like warming pattern[0.15℃-0.25℃(10 yr)^(−1) relative cooling in the eastern equatorial Pacific],over 80%of CMIP6 models project an erroneous El Niño-like trend.These discrepancies arise from biases in cloud feedbacks,Walker circulation strength,and oceanic upwelling processes.This review examines the key mechanisms shaping observed versus modeled warming patterns,evaluates the complex link between tropical SST patterns and TC activity,and explores the feasibility of storm-resolving models for improving TC projections.We propose that pattern-conditioned TC projections using convection-permitting models,alongside physics-informed interpretations,offer a path forward in reducing uncertainties in future climate predictions.
基金financially supported by the National Natural Science Foundation of China[grant number 42088101]。
文摘EC-Earth3P-HR reproduces well the observed Boreal Summer Intraseasonal Oscillation(BSISO)and its impacts on tropical cyclone genesis(TCG)in the western North Pacific(WNP).Hence,the historical simulation(1950-1979)and future projection under the SSP5-8.5 scenario(2020-2049)in EC-Earth3P-HR are adopted to explore possible changes in the BSISO’s modification of WNP TCG under global warming to enhance the understanding of TC activities in the WNP.Results show that the BSISO circulation in the WNP shifts northeastward under global warming.This leads to enhanced convection in a northwest-southeast-oriented band crossing the WNP.Along the band,the BSISO-related TCG anomalies are enhanced.Analyses of genesis potential index show that changes in the BSISO-related mid-tropospheric relative humidity play the dominant role in modifying the BSISO’s impacts on WNP TCG under global warming.The enhanced BSISO convection in the band moistens the middle troposphere,which helps reduce the entrainment of generally dry mid-tropospheric air in the updrafts and the modification of the boundary layer by the downdraft of generally dry mid-tropospheric air,leading to enhanced TCG.
基金Supported by the National Natural Science Foundation of China,No.82174461Capacity Enhancement Program of Xiyuan Hospital,China Academy of Traditional Chinese Medicine,No.XYZX0201-22Science and Technology Innovation Project of China Academy of Traditional Chinese Medicine,No.CI2021A01811.
文摘BACKGROUND There is a lack of integrated Chinese and Western medicine treatment regimens supported by high-level evidence-based medicine in the maintenance therapy phase of metastatic colorectal cancer(mCRC).Based on the traditional Chinese medicine theory of“Yin tumor”,we believe that“Yang does not transform Yin,and it is blocked in the intestines”is the core pathogenesis of mCRC.Based on the basic treatment principle of“warming Yang and dredging intestines”,we developed the Quxie Capsule.Previous randomized controlled clinical trials demonstrated that the Quxie Capsule can significantly prolong the overall survival of patients with mCRC,but it remains to be verified whether the combination of the“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong the efficacy and safety of the mCRC during the period of maintenance therapy.AIM To confirm and clinically validate that the combination of“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong progression-free survival(PFS)during maintenance treatment of mCRC.The safety of“warming Yang and dredging intestines method”prescription is also assessed.METHODS The study has a prospective,open-label,randomized,controlled study design.Patients have been recruited beginning November 2023 from Xiyuan Hospital of China Academy of Chinese Medical Sciences,Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Dongfang Hospital of Beijing University of Chinese Medicine,and Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine.The study period is from March 2024 to March 2026.After screening in outpatient clinics or wards,subjects who met the inclusion criteria are randomized into the treatment or control group in a 2:1 ratio.The treatment group receives the“warming Yang and dredging intestines method”formula combined with Western standard maintenance therapy.The control group receives Western standard maintenance therapy formulated by the investigators based on the Chinese Society of Clinical Oncology guidelines for colorectal cancer.All participants receive treatment until the occurrence of disease progression,death,or unmanageable adverse effects,with post-treatment monitoring continued until mortality.An independent panel of chief physicians with extensive clinical experience evaluates the progression of the disease.RESULTS This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.The goal is to provide a combined Chinese and Western medicine treatment option for clinical physicians and mCRC patients.Notably,with the actual sample size,this study has an 80%probability of detecting a significant difference if a true difference exists.Small sample sizes may lead to increased instability of the results of subgroup analyses,and may also result in findings that are only applicable to patients with characteristics highly similar to those of the present study population(e.g.,specific genotypes,therapeutic backgrounds,etc.),making it difficult to generalize to the broader mCRC population.In the future,it may be possible to expand the sample size based on this study to further validate the efficacy and safety of combining Chinese and Western medicine in the treatment of mCRC.Basic research on the therapeutic combination of warming Yang and dredging intestines method formula and standard Western regimen will be performed in parallel.CONCLUSION This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.
基金Supported by the 14th Five-Year National Key Research and Development Program of China(No.2022YFC3202004)the National Natural Science Foundation of China(No.42220104010)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20220041)the Young Scientists Group Project of Nanjing Institute of Geography and Limnology,Chinese Academy of Sciences,China(No.E1SL002)。
文摘Global warming has been reported to enhance thermal stratification and decrease the mixlayer depth(MLD)in waters due to higher surface water temperatures,especially in summer.Previous studies were conducted for individual cases or specific periods.At present,there is a lack of global assessments on the influence of climate warming in different seasons on thermal stratification.The ECMWF Reanalysis v5(ERA5)dataset was used to estimate the variability of water body mixing and its drivers in different seasons and regions.Results indicate that global warming could enhance thermal stratification and decrease the MLD globally in summer.Wind speed was the primary driver of MLD changes,followed by temperature.However,ice melt due to global warming enhanced the mixing in icecovered waters in the Northern Hemisphere,and early ice melt led to early mixing.Ice depth was the primary driver of MLD changes in the Northern Hemisphere due to delayed ice formation and earlier melting,while wind speed was the primary driver in other regions or during ice-free seasons.The enhanced mixing due to earlier ice melt out in late winter and early spring could promote water circulation and nutrient turnover,and replenish dissolved oxygen in deep water,thereby promoting the maximum biomass of cyanobacteria and advance harmful algal blooms.
