BACKGROUND There is a lack of integrated Chinese and Western medicine treatment regimens supported by high-level evidence-based medicine in the maintenance therapy phase of metastatic colorectal cancer(mCRC).Based on ...BACKGROUND There is a lack of integrated Chinese and Western medicine treatment regimens supported by high-level evidence-based medicine in the maintenance therapy phase of metastatic colorectal cancer(mCRC).Based on the traditional Chinese medicine theory of“Yin tumor”,we believe that“Yang does not transform Yin,and it is blocked in the intestines”is the core pathogenesis of mCRC.Based on the basic treatment principle of“warming Yang and dredging intestines”,we developed the Quxie Capsule.Previous randomized controlled clinical trials demonstrated that the Quxie Capsule can significantly prolong the overall survival of patients with mCRC,but it remains to be verified whether the combination of the“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong the efficacy and safety of the mCRC during the period of maintenance therapy.AIM To confirm and clinically validate that the combination of“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong progression-free survival(PFS)during maintenance treatment of mCRC.The safety of“warming Yang and dredging intestines method”prescription is also assessed.METHODS The study has a prospective,open-label,randomized,controlled study design.Patients have been recruited beginning November 2023 from Xiyuan Hospital of China Academy of Chinese Medical Sciences,Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Dongfang Hospital of Beijing University of Chinese Medicine,and Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine.The study period is from March 2024 to March 2026.After screening in outpatient clinics or wards,subjects who met the inclusion criteria are randomized into the treatment or control group in a 2:1 ratio.The treatment group receives the“warming Yang and dredging intestines method”formula combined with Western standard maintenance therapy.The control group receives Western standard maintenance therapy formulated by the investigators based on the Chinese Society of Clinical Oncology guidelines for colorectal cancer.All participants receive treatment until the occurrence of disease progression,death,or unmanageable adverse effects,with post-treatment monitoring continued until mortality.An independent panel of chief physicians with extensive clinical experience evaluates the progression of the disease.RESULTS This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.The goal is to provide a combined Chinese and Western medicine treatment option for clinical physicians and mCRC patients.Notably,with the actual sample size,this study has an 80%probability of detecting a significant difference if a true difference exists.Small sample sizes may lead to increased instability of the results of subgroup analyses,and may also result in findings that are only applicable to patients with characteristics highly similar to those of the present study population(e.g.,specific genotypes,therapeutic backgrounds,etc.),making it difficult to generalize to the broader mCRC population.In the future,it may be possible to expand the sample size based on this study to further validate the efficacy and safety of combining Chinese and Western medicine in the treatment of mCRC.Basic research on the therapeutic combination of warming Yang and dredging intestines method formula and standard Western regimen will be performed in parallel.CONCLUSION This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.展开更多
The method of warming the kidney and strengthening the spleen is widely used in the treatment of ulcerative colitis (UC) with significant curative effect.This paper reviews the relevant literature in recent years.
Soil microbes play important roles in terrestrial ecosystem carbon and nitrogen cycling. Climatic warming and elevated CO2 are two aspects of climatic change. In this study, we used a meta-analysis approach to synthes...Soil microbes play important roles in terrestrial ecosystem carbon and nitrogen cycling. Climatic warming and elevated CO2 are two aspects of climatic change. In this study, we used a meta-analysis approach to synthesise observations related to the effects of warming and elevated CO2 on soil microbial biomass and community structure. Ecosystem types were mainly grouped into forests and grasslands. Warming methods included open top chambers and infrared radiators. Experimental settings included all-day warming, daytime warming and nighttime warming. Warming increased soil actinomycetes and saprotrophic fungi, while elevated CO2 decreased soil gram-positive bacteria(G+). Mean annual temperature and mean annual precipitation were negatively correlated with warming effects on gram-negative bacteria(G–) and total phospholipid fatty acid(PLFA), respectively. Elevation was positively correlated with the warming effect on total PLFA, bacteria, G+ and G–. Grassland exhibited a positive response of total PLFA and actinomycetes to warming, while forest exhibited a positive response in the ratio of soil fungi to bacteria(F/B ratio) to warming. The open top chamber method increased G–, while the infrared radiator method decreased the F/B ratio. Daytime warming rather than all-day warming increased G–. Our findings indicated that the effects of warming on soil microbes differed with ecosystem types, warming methods, warming times, elevation and local climate conditions.展开更多
Objective： To observe the therapeutic effect of warm needling method for knee osteoarthritis. Methods： Three hundred cases were randomly divided into treatment group and control group, 150 cases respectively in each...Objective： To observe the therapeutic effect of warm needling method for knee osteoarthritis. Methods： Three hundred cases were randomly divided into treatment group and control group, 150 cases respectively in each group. The treatment group was treated by warm needling method, and the control group was treated by simple acupuncture. Their therapeutic effects were compared after 20 sessions of treatments. Results： The effective rate was 94.0% in the treatment group and 86.0% in the control group, with a significant difference between the two groups （P〈0.05）. Conclusion： The therapeutic effect is better in the warm needling group than in the control group in the treatment of knee osteoarthritis.展开更多
Objective： In order to compare the therapeutic effects between warming needle moxibustion plus Tuina therapy and single Tuina therapy for shoulder periarthritis. Methods： By random single blind control method, 80 ca...Objective： In order to compare the therapeutic effects between warming needle moxibustion plus Tuina therapy and single Tuina therapy for shoulder periarthritis. Methods： By random single blind control method, 80 cases were divided randomly into Group A （single Tuina group） and Group B （warming needle method plus Tuina group）, 40 cases in each group. Results： The effective rate was 95.0% in Group B and 85.0% in Group A, without significant difference （P〉0.05） in comparison between two groups. In assessment of Visual Analogue Scale, there was obvious decrease in both groups before and after the treatments （P〈0.01）. In comparison of VAS score differences between the two groups after the treatments, there was remarkable significant difference （P〈0.01）. Conclusion： Warming needle moxibustion plus Tuina is better than single Tuina therapy in stopping pain.展开更多
Objective： To observe the clinical efficacy of warm acupuncture in the treatment of diabetic peripheral neuropathy and its effects on the conduction velocity of the tibial nerve and common fibular nerve. Methods： Fi...Objective： To observe the clinical efficacy of warm acupuncture in the treatment of diabetic peripheral neuropathy and its effects on the conduction velocity of the tibial nerve and common fibular nerve. Methods： Fifty-two subjects were evenly randomized into two groups and treated by conventional therapy; in addition, the control group was given mecobalamin injection at 500μg, once a day for four weeks, and treatment group was given warm acupuncture, 6 times a week for 4 weeks. The clinical efficacy and the conduction velocity of the tibial nerve and common fibular nerve were observed and compared between the two groups. Results： After four-week treatments, the total effective rate was 88.5% in the treatment group and 61.5% in the control group, with a higher rate in the treatment group than in the control group （P〈0.05）; the conduction velocity of tibial nerve and common fibular nerve was higher in both groups （P〈0.05）, with higher conduction velocity in the treatment group than in the control group （P〈0.05）. Conclusion： Warm acupuncture is quite effective to treat diabetic peripheral neuropathy and to improve nerve velocity.展开更多
基金Supported by the National Natural Science Foundation of China,No.82174461Capacity Enhancement Program of Xiyuan Hospital,China Academy of Traditional Chinese Medicine,No.XYZX0201-22Science and Technology Innovation Project of China Academy of Traditional Chinese Medicine,No.CI2021A01811.
文摘BACKGROUND There is a lack of integrated Chinese and Western medicine treatment regimens supported by high-level evidence-based medicine in the maintenance therapy phase of metastatic colorectal cancer(mCRC).Based on the traditional Chinese medicine theory of“Yin tumor”,we believe that“Yang does not transform Yin,and it is blocked in the intestines”is the core pathogenesis of mCRC.Based on the basic treatment principle of“warming Yang and dredging intestines”,we developed the Quxie Capsule.Previous randomized controlled clinical trials demonstrated that the Quxie Capsule can significantly prolong the overall survival of patients with mCRC,but it remains to be verified whether the combination of the“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong the efficacy and safety of the mCRC during the period of maintenance therapy.AIM To confirm and clinically validate that the combination of“warming Yang and dredging intestines method”prescription with Western medicine standard regimen can prolong progression-free survival(PFS)during maintenance treatment of mCRC.The safety of“warming Yang and dredging intestines method”prescription is also assessed.METHODS The study has a prospective,open-label,randomized,controlled study design.Patients have been recruited beginning November 2023 from Xiyuan Hospital of China Academy of Chinese Medical Sciences,Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Dongfang Hospital of Beijing University of Chinese Medicine,and Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine.The study period is from March 2024 to March 2026.After screening in outpatient clinics or wards,subjects who met the inclusion criteria are randomized into the treatment or control group in a 2:1 ratio.The treatment group receives the“warming Yang and dredging intestines method”formula combined with Western standard maintenance therapy.The control group receives Western standard maintenance therapy formulated by the investigators based on the Chinese Society of Clinical Oncology guidelines for colorectal cancer.All participants receive treatment until the occurrence of disease progression,death,or unmanageable adverse effects,with post-treatment monitoring continued until mortality.An independent panel of chief physicians with extensive clinical experience evaluates the progression of the disease.RESULTS This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.The goal is to provide a combined Chinese and Western medicine treatment option for clinical physicians and mCRC patients.Notably,with the actual sample size,this study has an 80%probability of detecting a significant difference if a true difference exists.Small sample sizes may lead to increased instability of the results of subgroup analyses,and may also result in findings that are only applicable to patients with characteristics highly similar to those of the present study population(e.g.,specific genotypes,therapeutic backgrounds,etc.),making it difficult to generalize to the broader mCRC population.In the future,it may be possible to expand the sample size based on this study to further validate the efficacy and safety of combining Chinese and Western medicine in the treatment of mCRC.Basic research on the therapeutic combination of warming Yang and dredging intestines method formula and standard Western regimen will be performed in parallel.CONCLUSION This study aims to clarify whether the combination of warming Yang and dredging intestines method formula with standard Western medicine regimens can prolong PFS during maintenance therapy for mCRC and whether the treatment has a favorable safety profile.
文摘The method of warming the kidney and strengthening the spleen is widely used in the treatment of ulcerative colitis (UC) with significant curative effect.This paper reviews the relevant literature in recent years.
基金National Natural Science Foundation of China(31600432,41571042)The National Key Research Projects of China(2017YFA0604801)+2 种基金The Youth Innovation Research Team Project of Key Laboratory of Ecosystem Network Observation and Modeling(LENOM2016Q0002)Chinese Academy of Science Western Light Talents Program(Response of livestock carrying capability to climatic change and grazing in the alpine meadow of Northern Tibetan Plateau)Tibet Science and Technology Major Projects of Pratacultural Industry
文摘Soil microbes play important roles in terrestrial ecosystem carbon and nitrogen cycling. Climatic warming and elevated CO2 are two aspects of climatic change. In this study, we used a meta-analysis approach to synthesise observations related to the effects of warming and elevated CO2 on soil microbial biomass and community structure. Ecosystem types were mainly grouped into forests and grasslands. Warming methods included open top chambers and infrared radiators. Experimental settings included all-day warming, daytime warming and nighttime warming. Warming increased soil actinomycetes and saprotrophic fungi, while elevated CO2 decreased soil gram-positive bacteria(G+). Mean annual temperature and mean annual precipitation were negatively correlated with warming effects on gram-negative bacteria(G–) and total phospholipid fatty acid(PLFA), respectively. Elevation was positively correlated with the warming effect on total PLFA, bacteria, G+ and G–. Grassland exhibited a positive response of total PLFA and actinomycetes to warming, while forest exhibited a positive response in the ratio of soil fungi to bacteria(F/B ratio) to warming. The open top chamber method increased G–, while the infrared radiator method decreased the F/B ratio. Daytime warming rather than all-day warming increased G–. Our findings indicated that the effects of warming on soil microbes differed with ecosystem types, warming methods, warming times, elevation and local climate conditions.
基金Planned Project of Shanghai Commission of Science and Technology (08DZ1973200)Scientific Research Fund for Chinese Medicine of Shanghai Municipal Health Bureau(2008L010A)
文摘Objective： To observe the therapeutic effect of warm needling method for knee osteoarthritis. Methods： Three hundred cases were randomly divided into treatment group and control group, 150 cases respectively in each group. The treatment group was treated by warm needling method, and the control group was treated by simple acupuncture. Their therapeutic effects were compared after 20 sessions of treatments. Results： The effective rate was 94.0% in the treatment group and 86.0% in the control group, with a significant difference between the two groups （P〈0.05）. Conclusion： The therapeutic effect is better in the warm needling group than in the control group in the treatment of knee osteoarthritis.
文摘Objective： In order to compare the therapeutic effects between warming needle moxibustion plus Tuina therapy and single Tuina therapy for shoulder periarthritis. Methods： By random single blind control method, 80 cases were divided randomly into Group A （single Tuina group） and Group B （warming needle method plus Tuina group）, 40 cases in each group. Results： The effective rate was 95.0% in Group B and 85.0% in Group A, without significant difference （P〉0.05） in comparison between two groups. In assessment of Visual Analogue Scale, there was obvious decrease in both groups before and after the treatments （P〈0.01）. In comparison of VAS score differences between the two groups after the treatments, there was remarkable significant difference （P〈0.01）. Conclusion： Warming needle moxibustion plus Tuina is better than single Tuina therapy in stopping pain.
文摘Objective： To observe the clinical efficacy of warm acupuncture in the treatment of diabetic peripheral neuropathy and its effects on the conduction velocity of the tibial nerve and common fibular nerve. Methods： Fifty-two subjects were evenly randomized into two groups and treated by conventional therapy; in addition, the control group was given mecobalamin injection at 500μg, once a day for four weeks, and treatment group was given warm acupuncture, 6 times a week for 4 weeks. The clinical efficacy and the conduction velocity of the tibial nerve and common fibular nerve were observed and compared between the two groups. Results： After four-week treatments, the total effective rate was 88.5% in the treatment group and 61.5% in the control group, with a higher rate in the treatment group than in the control group （P〈0.05）; the conduction velocity of tibial nerve and common fibular nerve was higher in both groups （P〈0.05）, with higher conduction velocity in the treatment group than in the control group （P〈0.05）. Conclusion： Warm acupuncture is quite effective to treat diabetic peripheral neuropathy and to improve nerve velocity.
