目的分析肥胖相关指标对中老年人认知功能的影响及其剂量-反应关系,为中老年人认知功能干预提供参考。方法选取“中国健康与营养调查”1997—2018年至少具有2轮完整数据的≥55岁中老年人作为研究对象。计算体质量指数(body mass index,B...目的分析肥胖相关指标对中老年人认知功能的影响及其剂量-反应关系,为中老年人认知功能干预提供参考。方法选取“中国健康与营养调查”1997—2018年至少具有2轮完整数据的≥55岁中老年人作为研究对象。计算体质量指数(body mass index,BMI)、体重调整腰围指数(weight-adjusted-waist index,WWI)和相对脂肪量指数(relative fat mass index,RFMI)。采用认知功能电话筛查量表的部分条目评估认知功能。采用多水平模型分析不同肥胖评估指标与认知功能的关系,并进行亚组分析。采用限制性立方样条回归模型分析肥胖相关指标与认知功能的剂量-反应关系。结果本研究共纳入5251人,有888人(16.91%)检出认知功能低下。调整所有协变量后,BMI(β=0.07,95%CI:0.04~0.10)和腰围(β=0.02,95%CI:0.01~0.03)均与中老年人总体认知功能评分呈正相关。与正常体质量组相比,低体质量中老年人总体认知评分降低0.43分(95%CI:-0.79~-0.07),而超重肥胖组增加0.34分(95%CI:0.13~0.55)。中心型肥胖组评分较正常组增加0.37分(95%CI:0.17~0.57)。相反,较高的WWI和RFMI(Q2~Q4)与总体认知评分呈负相关。超重肥胖或中心型肥胖的中老年人发生认知功能低下的可能性较对照组分别降低11%(95%CI:0.80~1.00)和15%(95%CI:0.76~0.94),且超重肥胖和中心型肥胖对女性作用明显,而中心型肥胖对男性无显著影响。低体质量(OR=1.37,95%CI:1.08~1.75)和高WWI(OR=1.21,95%CI:1.02~1.44)增加男性发生认知功能低下的可能性。BMI、腰围和WWI与中老年人认知功能存在剂量-反应关系,BMI和腰围在一定较高的范围内可改善认知功能,降低认知功能低下可能性,而WWI则相反。结论较高的BMI和腰围、超重肥胖和中心型肥胖有利于维护我国≥55岁中老年人认知功能、降低认知功能低下的可能性,而较高的WWI和RFMI是中老年人认知功能的危险因素。展开更多
Background: Obesity is associated with higher end-stage renal disease incidence, but associations with earlier forms of kidney disease remain incompletely characterized. Methods: We studied the association of body mas...Background: Obesity is associated with higher end-stage renal disease incidence, but associations with earlier forms of kidney disease remain incompletely characterized. Methods: We studied the association of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with rapid kidney function decline and incident chronic kidney disease in 4573 non-diabetic adults with eGFR ≥ 60 ml/min/1.73m2 at baseline from longitudinal Multi-Ethnic Study of Atherosclerosis cohort. Kidney function was estimated by creatinine and cystatin C. Multivariate analysis was adjusted for age, race, baseline eGFR, and hypertension. Results: Mean age was 60 years old, BMI 28 kg/m2, baseline eGFRCr 82 and eGFRCys 95 ml/min/1.73m2. Over 5 years of follow up, 25% experienced rapid decline in renal function by eGFRCr and 22% by eGFRCys. Incident chronic kidney disease (CKD) developed in 3.3% by eGFRCys, 11% by eGFRCr, and 2.4% by both makers. Compared to persons with BMI 25, overweight (BMI 25 - 30) persons had the?lowest risk of rapid decline by eGFRCr (0.84, 0.71 - 0.99). In contrast, higher BMI categories were associated with stepwise higher odds of rapid decline by eGFRCys, but remained significant only when BMI ≥ 35 kg/m2 (1.87, 1.41 - 2.48). Associations of BMI with incident CKD were insignificant after adjustment. Large WC and WHR were associated with increased risk of rapid decline only by eGFRCys, and of incident CKD only when defined by both filtration markers. Conclusions: Obesity may be a risk factor for kidney function decline, but associations vary by filtration marker used.展开更多
目的探究活血止痛膏联合推拿对气滞血瘀型急性腰扭伤患者临床症状、腰功能以及生活质量的影响。方法2021年1月—2023年1月期间,在医院随机选取气滞血瘀型急性腰扭伤患者98例,采用随机数字表法分为观察组51例和对照组47例。所有患者均行...目的探究活血止痛膏联合推拿对气滞血瘀型急性腰扭伤患者临床症状、腰功能以及生活质量的影响。方法2021年1月—2023年1月期间,在医院随机选取气滞血瘀型急性腰扭伤患者98例,采用随机数字表法分为观察组51例和对照组47例。所有患者均行常规治疗,对照组在其基础上联合推拿治疗,观察组在对照组基础上联合活血止痛膏治疗。对比两组治疗疗效及安全性,治疗前后对患者进行中医证候评分、腰椎活动度(ROM)检测,同时采用腰痛评分标准(the oswestry disability index,ODI)、简明健康状况调查表(short form 36 health survey questionnaire,SF-36)对所有患者进行评估。结果观察组治疗总有效率高于对照组(90.20%vs 74.47%)(P<0.05),两组均未发生严重不良反应。治疗后,观察组中医证候“腰部活动受限、肌肉痉挛、肿胀以及腰痛”得分均低于对照组(P<0.05)。治疗后,观察组左右侧屈、前屈角度均大于对照组(P<0.05),两组后伸角度无差异(P>0.05)。治疗后,观察组ODI得分低于对照组,SF-36高于对照组,差异具有统计学意义(P<0.05)。结论活血止痛膏联合推拿治疗气滞血瘀型急性腰扭伤,能够有效缓解病症,改善患者腰功能障碍,提高患者的生活质量,且安全性较好。展开更多
目的:观察利拉鲁肽对初诊肥胖2型糖尿病患者腰围和胰岛功能的影响。方法:选取体重指数(body mass index,BMI)≥28 kg/m^2初诊2型糖尿病患者38例,应用利拉鲁肽注射液治疗24周,比较治疗前后患者的空腹血糖(fasting blood glucose,FBG),餐...目的:观察利拉鲁肽对初诊肥胖2型糖尿病患者腰围和胰岛功能的影响。方法:选取体重指数(body mass index,BMI)≥28 kg/m^2初诊2型糖尿病患者38例,应用利拉鲁肽注射液治疗24周,比较治疗前后患者的空腹血糖(fasting blood glucose,FBG),餐后2 h血糖(2 h blood glucose,2h PG)、糖化血红蛋白(hemoglobin a1c,Hb Alc)、甘油三酯(triacylglyceride,TG)、低密度脂蛋白(low density lipoprotein cholesterol,L-DLC)、BMI、腰围(waist circumference,WC)、空腹胰岛素(fasting insulin,FIns)、胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR)、胰岛素敏感指数(homeostasis model assessment index ofβcell,HOMA-β)。结果:与治疗前比较,患者的FBG、Hb A1c、TG、BMI、HOMA-IR均下降(P<0.05)。治疗后的HOMA-β与治疗前相比升高(P<0.05)。结论:对初诊肥胖的2型糖尿病患者,利拉鲁肽能够有效控制血糖、减小腰围、减轻胰岛素抵抗、提高胰岛素敏感性、改善胰岛β细胞功能。展开更多
文摘目的分析肥胖相关指标对中老年人认知功能的影响及其剂量-反应关系,为中老年人认知功能干预提供参考。方法选取“中国健康与营养调查”1997—2018年至少具有2轮完整数据的≥55岁中老年人作为研究对象。计算体质量指数(body mass index,BMI)、体重调整腰围指数(weight-adjusted-waist index,WWI)和相对脂肪量指数(relative fat mass index,RFMI)。采用认知功能电话筛查量表的部分条目评估认知功能。采用多水平模型分析不同肥胖评估指标与认知功能的关系,并进行亚组分析。采用限制性立方样条回归模型分析肥胖相关指标与认知功能的剂量-反应关系。结果本研究共纳入5251人,有888人(16.91%)检出认知功能低下。调整所有协变量后,BMI(β=0.07,95%CI:0.04~0.10)和腰围(β=0.02,95%CI:0.01~0.03)均与中老年人总体认知功能评分呈正相关。与正常体质量组相比,低体质量中老年人总体认知评分降低0.43分(95%CI:-0.79~-0.07),而超重肥胖组增加0.34分(95%CI:0.13~0.55)。中心型肥胖组评分较正常组增加0.37分(95%CI:0.17~0.57)。相反,较高的WWI和RFMI(Q2~Q4)与总体认知评分呈负相关。超重肥胖或中心型肥胖的中老年人发生认知功能低下的可能性较对照组分别降低11%(95%CI:0.80~1.00)和15%(95%CI:0.76~0.94),且超重肥胖和中心型肥胖对女性作用明显,而中心型肥胖对男性无显著影响。低体质量(OR=1.37,95%CI:1.08~1.75)和高WWI(OR=1.21,95%CI:1.02~1.44)增加男性发生认知功能低下的可能性。BMI、腰围和WWI与中老年人认知功能存在剂量-反应关系,BMI和腰围在一定较高的范围内可改善认知功能,降低认知功能低下可能性,而WWI则相反。结论较高的BMI和腰围、超重肥胖和中心型肥胖有利于维护我国≥55岁中老年人认知功能、降低认知功能低下的可能性,而较高的WWI和RFMI是中老年人认知功能的危险因素。
文摘Background: Obesity is associated with higher end-stage renal disease incidence, but associations with earlier forms of kidney disease remain incompletely characterized. Methods: We studied the association of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with rapid kidney function decline and incident chronic kidney disease in 4573 non-diabetic adults with eGFR ≥ 60 ml/min/1.73m2 at baseline from longitudinal Multi-Ethnic Study of Atherosclerosis cohort. Kidney function was estimated by creatinine and cystatin C. Multivariate analysis was adjusted for age, race, baseline eGFR, and hypertension. Results: Mean age was 60 years old, BMI 28 kg/m2, baseline eGFRCr 82 and eGFRCys 95 ml/min/1.73m2. Over 5 years of follow up, 25% experienced rapid decline in renal function by eGFRCr and 22% by eGFRCys. Incident chronic kidney disease (CKD) developed in 3.3% by eGFRCys, 11% by eGFRCr, and 2.4% by both makers. Compared to persons with BMI 25, overweight (BMI 25 - 30) persons had the?lowest risk of rapid decline by eGFRCr (0.84, 0.71 - 0.99). In contrast, higher BMI categories were associated with stepwise higher odds of rapid decline by eGFRCys, but remained significant only when BMI ≥ 35 kg/m2 (1.87, 1.41 - 2.48). Associations of BMI with incident CKD were insignificant after adjustment. Large WC and WHR were associated with increased risk of rapid decline only by eGFRCys, and of incident CKD only when defined by both filtration markers. Conclusions: Obesity may be a risk factor for kidney function decline, but associations vary by filtration marker used.
文摘目的探究活血止痛膏联合推拿对气滞血瘀型急性腰扭伤患者临床症状、腰功能以及生活质量的影响。方法2021年1月—2023年1月期间,在医院随机选取气滞血瘀型急性腰扭伤患者98例,采用随机数字表法分为观察组51例和对照组47例。所有患者均行常规治疗,对照组在其基础上联合推拿治疗,观察组在对照组基础上联合活血止痛膏治疗。对比两组治疗疗效及安全性,治疗前后对患者进行中医证候评分、腰椎活动度(ROM)检测,同时采用腰痛评分标准(the oswestry disability index,ODI)、简明健康状况调查表(short form 36 health survey questionnaire,SF-36)对所有患者进行评估。结果观察组治疗总有效率高于对照组(90.20%vs 74.47%)(P<0.05),两组均未发生严重不良反应。治疗后,观察组中医证候“腰部活动受限、肌肉痉挛、肿胀以及腰痛”得分均低于对照组(P<0.05)。治疗后,观察组左右侧屈、前屈角度均大于对照组(P<0.05),两组后伸角度无差异(P>0.05)。治疗后,观察组ODI得分低于对照组,SF-36高于对照组,差异具有统计学意义(P<0.05)。结论活血止痛膏联合推拿治疗气滞血瘀型急性腰扭伤,能够有效缓解病症,改善患者腰功能障碍,提高患者的生活质量,且安全性较好。
文摘目的:观察利拉鲁肽对初诊肥胖2型糖尿病患者腰围和胰岛功能的影响。方法:选取体重指数(body mass index,BMI)≥28 kg/m^2初诊2型糖尿病患者38例,应用利拉鲁肽注射液治疗24周,比较治疗前后患者的空腹血糖(fasting blood glucose,FBG),餐后2 h血糖(2 h blood glucose,2h PG)、糖化血红蛋白(hemoglobin a1c,Hb Alc)、甘油三酯(triacylglyceride,TG)、低密度脂蛋白(low density lipoprotein cholesterol,L-DLC)、BMI、腰围(waist circumference,WC)、空腹胰岛素(fasting insulin,FIns)、胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR)、胰岛素敏感指数(homeostasis model assessment index ofβcell,HOMA-β)。结果:与治疗前比较,患者的FBG、Hb A1c、TG、BMI、HOMA-IR均下降(P<0.05)。治疗后的HOMA-β与治疗前相比升高(P<0.05)。结论:对初诊肥胖的2型糖尿病患者,利拉鲁肽能够有效控制血糖、减小腰围、减轻胰岛素抵抗、提高胰岛素敏感性、改善胰岛β细胞功能。
