A deep-sea mining riser is a crucial component of the system used to lift seafloor mineral resources to the vessel.It is prone to damage and failure because of harsh environmental conditions and internal fluid erosion...A deep-sea mining riser is a crucial component of the system used to lift seafloor mineral resources to the vessel.It is prone to damage and failure because of harsh environmental conditions and internal fluid erosion.Furthermore,damage can impact the response characteristics of the riser,but varying environmental loadings easily mask it.Thus,distin-guishing between riser damage and environmental effects poses a considerable challenge.To address this issue,a cantilevered model is created for a deep-sea mining riser via the concentrated mass method,and a time-domain analytical strategy is developed.The vortex-induced vibration(VIV)response characteristics of the riser are initially examined,considering various damage conditions and flow velocities.The study results revealed four primary observations:(a)effective tension can serve as a reliable indicator for identifying damage at lower velocities;(b)there are noticeable differences in displacement between the healthy and damaged risers in the in-line direction rather than the cross-flow direction;(c)frequency characteristics can more effectively distinguish the damage conditions at high flow velocities,with the mean square frequency and frequency variance being more effective than the centroid frequency and root variance frequency;(d)displacement differences are more sensitive to damage occurring near the top and bottom of the riser,while both velocity variations and structural damage can influence displacements,especially in regions between modal nodes.The vibrational behavior and damage indicators are clarified for structural health monitoring of deep-sea mining risers during lifting operations.展开更多
Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response ...Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response of an underwater manipulator subjected to pulsating flow,focusing on how different postures affect the behavior of the system.The effects of pulsating parameters and manipulator arrangement on the hydrodynamic coefficient,vibration response,motion trajectory,and vortex shedding behaviors were analyzed.Results indicated that the cross flow vibration displacement in pulsating flow increased by 32.14%compared to uniform flow,inducing a shift in the motion trajectory from a crescent shape to a sideward vase shape.In the absence of interference between the upper and lower arms,the lift coefficient of the manipulator substantially increased with rising pulsating frequency,reaching a maximum increment of 67.0%.This increase in the lift coefficient led to a 67.05%rise in the vibration frequency of the manipulator in the in-line direction.As the pulsating amplitude increased,the drag coefficient of the underwater manipulator rose by 36.79%,but the vibration frequency in the cross-flow direction decreased by 56.26%.Additionally,when the upper and lower arms remained in a state of mutual interference,the cross-flow vibration amplitudes of the upper and lower arms were approximately 1.84 and 4.82 times higher in a circular-elliptical arrangement compared to an elliptical-circular arrangement,respectively.Consequently,the flow field shifted from a P+S pattern to a disordered pattern,disrupting the regularity of the motion trajectory.展开更多
BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary app...BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.展开更多
To achieve the goals of sustainable development of the energy system and the construction of a lowcarbon society,this study proposes a multi-energy storage collaborative optimization strategy for industrial park that ...To achieve the goals of sustainable development of the energy system and the construction of a lowcarbon society,this study proposes a multi-energy storage collaborative optimization strategy for industrial park that integrates the laddered carbon trading mechanism with demand response.Firstly,a dual dimensional DR model is constructed based on the characteristics of load elasticity.The alternativeDRenables flexible substitution of energy loads through complementary conversion of electricity/heat/cold multi-energy sources,while the price DR relies on timeof-use electricity price signals to guide load spatiotemporal migration;Secondly,the LCT mechanism is introduced to achieve optimal carbon emission costs through a tiered carbon quota allocation mechanism.On this basis,an optimization decision model is established with the core objective of maximizing the annual net profit of the park.The objective function takes into account energy sales revenue,generator unit costs,and investment and operation costs of multiple types of energy storage facilities.Themodel constraint system covers three key dimensions:dynamic operation constraints of power generation units,including unit output limits,ramping capability,and minimum start-stop time;the physical boundary of an electric/hot/cold multi-energy storage system involves energy storage capacity and charge/discharge efficiency;The multi-energy network coupling balance equation ensures that the energy conversion and transmission process satisfies the law of conservation of energy.Using CPLEX mathematical programming solver for simulation verification,construct an energy storage capacity configuration decision process that includes LCT-DR synergistic effect.The research results show that compared with the traditional single energy storage configuration mode,this strategy effectively enhances the economic feasibility and engineering practicality of industrial park operation by coordinating demand side resource scheduling and finely controlling carbon costs,while maintaining stable system operation.Its methodological framework provides a technical path that combines theoretical rigor and practical operability for the low-carbon transformation of regional integrated energy systems.展开更多
Foliar uptake of airborne metal(loid)s plays a crucial role in metal(loid)accumulation in plant organs and is influ-enced by the size and emission sources of aerosols.Given the high enrichment of toxic metal(loid)s in...Foliar uptake of airborne metal(loid)s plays a crucial role in metal(loid)accumulation in plant organs and is influ-enced by the size and emission sources of aerosols.Given the high enrichment of toxic metal(loid)s in submicron-scale particulates(PM1),this study established a PM1 exposure system to examine airborne metal(loid)accu-mulation and foliar physiological responses in Oryza sativa L.The results showed that the concentrations of Cu,Zn,As,Pb,and Cd in the leaves and grains were influenced not only by the airborne metal(loid)levels but also by the specific nature of the PM1 particles.The quantitative model for PM1-associated Pb entry into leaf tissue indicated that foliar Pb accumulation was primarily driven by particle adhesion,followed by hydrophilic pene-tration and trans-stomatal liquid film migration,accounting for 87%–89%of the total accumulation.The strong hygroscopicity and high Pb activity of PM1 emitted from waste incineration(WI)increased the Pb absorption coefficient via the hydrophilic and liquid film migration pathway.In contrast,the high hydrophobicity of PM1 from coal burning(CB)led to greater retention of Pb on leaf surfaces.Both foliar reactive oxygen metabolism and photosynthesis indices were sensitive to air pollution.Foliar metal(loid)accumulation and airborne PM1 concentration accounted for the variance in physiological responses in rice leaves.Our results also indicated that Pb was the key element in PM1 emissions from both coal burning(CB)and waste incineration(WI)responsible for significant physiological changes in rice leaves.展开更多
Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immun...Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immune tolerance of cancer cells.The classical theory holds that prostate apoptosis response-4(PAR-4)is a tumor suppressor protein.However,our recent research has found that PAR-4 has a biological function of promoting cancer in hepatocellular carcinoma(HCC),and our analysis shows that PAR-4 can be modified of lactic acid.These research evidences suggest that PAR-4 lactylation modification may drive immune tolerance in HCC.Therefore,inhibiting PAR-4 lactylation modification is very likely to increase the sensitivity of HCC to immunotherapy.展开更多
Based on Iwan′s wake oscillator model developed with the classical van der Pol equation, the differential equation for the response of the vortex-induced vibration (VIV) of the riser considering the effect of the int...Based on Iwan′s wake oscillator model developed with the classical van der Pol equation, the differential equation for the response of the vortex-induced vibration (VIV) of the riser considering the effect of the internal flowing fluid and the external marine environmental condition is derived. The effect of the internal flowing fluid on the response of VIV of the riser is studied by means of the Finite Element Method. The results show that the effect of the internal fluid velocity on the VIV of the riser is strong when the natural frequency of the riser is close to the vortex shedding frequency. In addition, the increase of the top tension can decrease the sensitivity of the riser to the internal fluid velocity.展开更多
Owing to the inherent limitation of the internal pulse ionization chamber within the AlphaGUARD PQ2000 radon monitor,that is,its inability to discriminate the energy levels of α particles,the ingress of^(220)Rn from ...Owing to the inherent limitation of the internal pulse ionization chamber within the AlphaGUARD PQ2000 radon monitor,that is,its inability to discriminate the energy levels of α particles,the ingress of^(220)Rn from the surrounding environment,along with its decay progeny,poses a substantive challenge in accurately determining the^(222)Rn concentration in the measurement outcomes.Among these,the protracted influence primarily stems from the two enduring decay progenies,namely^(212)Pb with a half-life of 10.64 h and^(212)Bi with a half-life of 60.54 min.This study explored the influence of^(220)Rn progeny on the measurement results of an AlphaGUARD PQ2000 radon monitor by developing a theoretical calculation model.The response coefficient related to the residual^(220)Rn progeny within the AlphaGUARD PQ2000 radon monitor was experimentally validated.In addition,this study investigated the effects of temperature and wind speed on the sensitivity of the instrument to^(220)Rn gas.The research findings revealed commendable agreement between the experimentally measured response coefficients of the residual^(220)Rn progeny and the corresponding values derived from the theoretical model.Notably,both the response coefficients of the AlphaGUARD PQ2000 radon monitor to^(220)Rn gas and its internal residual^(220)Rn progeny increased with elevated temperatures and increased wind speeds,providing a reference for correcting the impact of^(220)Rn and its progeny on the measurement results of^(222)Rn concentration obtained using the AlphaGUARD PQ2000 radon monitor.展开更多
Vortex-induced vibration(VIV)for flexible cylinders under combined uniform and oscillatory flow is a challenging and practical issue in ocean engineering.In this paper,a time domain numerical model is adopted to inves...Vortex-induced vibration(VIV)for flexible cylinders under combined uniform and oscillatory flow is a challenging and practical issue in ocean engineering.In this paper,a time domain numerical model is adopted to investigate the characteristics of cross-flow VIV response and fatigue damage under different combined flow cases.Firstly,the adopted VIV model and fatigue analysis procedure are validated well against the published experimental results of a4-m cylinder model under pure oscillatory flows.Then,forty-five combined flow cases of the same cylinder model are designed to reveal the VIV response characteristics with different non-dimensional oscillation period T^*and combined ratio r.The combined flow cases are classified into three categories to investigate the effect of r on cylinder’s dynamic response,and the effect of T*is described under long and short period cases.Finally,fatigue analysis is carried out to investigate how the structural fatigue damage varies with the variations of r and T^*.The captured characteristics of structural response and fatigue damage are explained through the VIV mechanism analysis.展开更多
The mechanical behavior,dynamic evolution,and flow-field distribution of a two-degree-of-freedom riserless drill string were simulated numerically by using FLUENT fluid simulation software with the user-defined functi...The mechanical behavior,dynamic evolution,and flow-field distribution of a two-degree-of-freedom riserless drill string were simulated numerically by using FLUENT fluid simulation software with the user-defined function embedded.The rotation angular velocities before and after the critical rotation angular velocity were used as independent variables,and the reduced velocity range was 3-14.Fluid-structure coupling was realized based on the dynamic overset grid and the SST k-ωturbulence model.Results reveal that the dynamic response of the riserless drill string was considerably affected by rotation and flow velocity,which are coupled with each other.The cross-flow average dimensionless displacement increased with the rotation angular velocity,and rotation considerably enhanced the in-line maximum average dimensionless displacement.However,the cross-flow amplitude caused by vortex-induced vibration was suppressed when the rotation angular velocity reached a certain value.The in-line and cross-flow frequencies were the same,thereby causing the trajectory to deviate from the standard'figure-eight'shape and become a closed circle shape.The vortex did not fall behind the cylinder at low reduced velocity with high-rotation angular velocity,and the structure of the near-wake vortex remained U-shaped.The wake of the cylinder was deflected along the cross-flow direction,thereby leading to vibration asymmetry and resulting in increased vibration instability and disordered vibration trajectories,especially at high-rotation angular velocities.展开更多
In offshore engineering, the phenomenon of free span often occurs, and the pipeline may have multiple free spans adjacent to each other, forming a multi-span pipeline. The interaction of different spans makes the stru...In offshore engineering, the phenomenon of free span often occurs, and the pipeline may have multiple free spans adjacent to each other, forming a multi-span pipeline. The interaction of different spans makes the structural vibration characteristics more complex, which may change the fatigue characteristics of the pipeline and affect the safety of the structure. In this paper, model tests were designed to explore the vortex-induced vibration(VIV) characteristics of multi-span pipelines and investigate the multi-span interaction mechanism. The experimental study mainly focused on the dynamic response of double-span pipelines, and further extended to triple-span pipelines, hoping that the results can be applied to more complex environment. The effects of span-length ratio, buried depth and axial force on VIV of the pipeline were investigated and discussed. The dynamic response of the pipeline varied with the span length. There was obvious interaction between different spans of multi-span pipelines, and the pipe-sediment interaction obviously affected the vibration characteristics of pipeline. The differences of pipeline burial depth and axial force changed the structural stiffness. With the increase of buried depth, the response amplitude presented a downward trend. The spanwise evolutions were asymmetric caused by the pipe-sediment interaction and multi-span interaction. The results can help to identify multi-span pipelines in engineering, and realize the prevention and control of free spans.展开更多
A three-dimensional numerical scheme was developed to investigate the vortex-induced vibration(VIV)of a catenary-type riser(CTR)in the in-line(IL)and cross-flow(CF)directions.By using the vector form intrinsic finite ...A three-dimensional numerical scheme was developed to investigate the vortex-induced vibration(VIV)of a catenary-type riser(CTR)in the in-line(IL)and cross-flow(CF)directions.By using the vector form intrinsic finite element method,the CTR was discretized into a finite number of spatial particles whose motions satisfy Newton’s second law.The Van der Pol oscillator was used to simulate the effect of vortex shedding.The coupling equations of structural vibration and wake oscillator were solved using an explicit central differential algorithm.The numerical model was verified with the published results.The VIV characteristics of the CTR subjected to uniform flows,including displacement,frequency,standing wave,traveling wave,motion trajectory,and energy transfer,were studied comprehensively.The numerical results revealed that the multimode property occurs in the CF-and IL-direction VIV responses of the CTR.An increase in the flow velocity has slight effects on the maximum VIV displacement.Due to structural nonlin-earity,the double-frequency relationship in the CF and IL directions is rarely captured.Therefore,the vibration trajectories display the shape of an inclined elliptical orbit.Moreover,the negative energy region is inconspicuous under the excitation of the uniform flow.展开更多
A numerical simulation analysis is conducted to examine the unsteady hydrodynamic characteristics of vortex-induced vibration(VIV)and the suppression effect of helical strakes on VIV in subsea pipelines.The analysis u...A numerical simulation analysis is conducted to examine the unsteady hydrodynamic characteristics of vortex-induced vibration(VIV)and the suppression effect of helical strakes on VIV in subsea pipelines.The analysis uses the standard k−εturbulence model for 4.5-and 12.75-inch pipes,and its accuracy is verified by comparing the results with large-scale hydrodynamic experiments.These experiments are designed to evaluate the suppression efficiency of VIV with and without helical strakes,focusing on displacement and drag coefficients under different flow conditions.Furthermore,the influence of important geometric parameters of the helical strakes on drag coefficients and VIV suppression efficiency at different flow rates is compared and discussed.Numerical results agree well with experimental data for drag coefficient and vortex shedding frequency.Spring-pipe self-excited vibration experimental tests reveal that the installation of helical strakes substantially reduces the drag coefficient of VIV within a certain flow rate range,achieving suppression efficiencies exceeding 90%with strake heights larger than 0.15D.Notably,the optimized parameter combination of helical strakes,with a pitch of 15D,a fin height of 0.2D,and 45°edge slopes,maintains high suppression efficiency,thereby exhibiting superior performance.This study provides a valuable reference for the design and application of helical strakes and VIV suppression in subsea engineering.展开更多
This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and stru...This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and structural response of the platform are studied,considering the actual platform motion and free surface rise under extreme sea states.First,the effects of the wave frequency and direction on the wave-induced loads and dynamic responses were examined.The motion at a wave direction angle of 0°is relatively low.On this basis,the angle constrained by the two sides of the Sharp Eagle floaters should be aligned with the main wave direction to avoid significant platform motion under extreme sea states.Additionally,the structural response of the platform,including the wave-absorbing floaters,is investigated.The results highlighted that the conditions or locations where yielding,buckling,and fatigue failures occur were different.In this context,the connection area of the Sharp Eagle floaters and platform is prone to yielding failure under oblique wave action,whereas the pontoon and side of the Sharp Eagle floaters are prone to buckling failure during significant vertical motion.Additionally,fatigue damage is most likely to occur at the connection between the middle column on both sides of the Sharp Eagle floaters and the pontoons.The findings of this paper revealed an intrinsic connection between wave-induced loads and the dynamic and structural responses of the platform,which provides a useful reference for the improved design of WECs.展开更多
The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and di...The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and discrete element method(DEM)was employed to investigate the mechanical behavior of asphalt pavement containing a pre-existing TD crack.The mesoscopic parameters of the model were calibrated based on the mixture modulus and the static mechanical response on the MLS66 test road.Finally,an analysis was performed to assess how variations in TD crack depth and longitudinal length affect the distribution patterns of transverse tensile stress,vertical shear stress,and vertical compressive stress.The results indicate that the vertical propagation of TD crack significantly increases both the tensile stress value and range on the middle surface,while the longitudinal development of TD crack has minimal impact.This phenomenon may result in more severe fatigue failure on the middle surface.With the vertical and longitudinal development of TD crack,the vertical shear stress and compressive stress show obvious"two-stage"characteristics.When the crack's vertical length reaches 40 mm,there is a sharp increase in stress on the upper surface.As the crack continues to propagate vertically,the growth of stress on the upper surface becomes negligible,while the stress in the middle and lower layers increased significantly.Conversely,for longitudinal development of TD crack,any changes in stress are insignificant when their length is less than 180 mm;however,as they continue to develop longitudinally beyond this threshold,there is a sharp increase in stress levels.These findings hold great significance for understanding pavement structure deterioration and maintenance behavior associated with TD crack.展开更多
BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing...BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing models is challenging due to the variety of diseases involved in gastrointestinal surgery and the com-plex factors contributing to patient stress responses.Moreover,stress responses are more severe in older adult patients.Therefore,precision medicine is required to improve the quality of nursing care and promote postoperative recovery in gastrointestinal surgery.and demonstrate nursing benefits through clinical practice.METHODS This randomized clinical trial first established an evidence-based nursing ERAS protocol in older adult patients based on literature related to perioperative nursing measures for gastrointestinal surgery stress response.Next,392 older adult patients who underwent gastrointestinal surgery and were admitted to our hospital between December 2021 and June 2023 were categorized into two groups to receive evidence-based(study group)or conventional(control group)ERAS nursing models,respectively.Intraoperative physiological parameters during surgery and postoperative recovery indicators were compared between the groups.RESULTS Among 64 domestic and international studies,the stress responses of older adult patients mainly included emotional anxiety,sleep disorders,gastrointestinal discomfort,physical weakness,pain,and swelling.The appropriate nursing interventions included comprehensive psychological counseling,pre-and postoperative nutritional support,temperature control,pain management,and rehabilitation training.Compared with the control group,the study group showed lower heart rate,mean arterial pressure,blood glucose level,and adrenaline level;shorter duration of drainage tube placement,time to first flatus,time to first ambulation,and postoperative hospital stay;lower anxiety scores on postoperative day 3;and lower incidences of postoperative infection,obstruction,poor wound healing,and gastrointestinal reactions were lower in the study group(all P<0.05).CONCLUSION The evidence-based nursing measures targeting stress responses based on the conventional ERAS nursing model resulted in stable intraoperative physiological parameters during surgery,promoted postoperative recovery,and reduced the incidence of complications.展开更多
The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increas...The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increased genomic instability and promoting tumor progression.Consequently,targeting DDR mechanisms has emerged as a promising therapeutic strategy in oncology.This review provides an overview of the major DDR pathways,highlighting the roles of key proteins involved in various DDR processes.A detailed understanding of these molecular mechanisms has paved the way for the development of targeted antitumor agents,including inhibitors of PARP1,ATM,ATR,CHK1,CHK2,DNA-PK,and WEE1.Additionally,the significant challenges in the development of DDR inhibitors are examined,including tumor microenvironment heterogeneity,resistance mechanisms,issues with selectivity and toxicity,and the complexities associated with clinical trial design.Finally,future directions and emerging strategies to improve DDR-targeted therapies are discussed.These strategies include biomarker-driven precision medicine,novel combination therapies,advanced drug delivery systems,and the potential application of artificial intelligence to optimize treatment outcomes.展开更多
The vibration response and noise caused by subway trains can affect the safety and comfort of superstructures.To study the dynamic response characteristics of subway stations and superstructures under train loads with...The vibration response and noise caused by subway trains can affect the safety and comfort of superstructures.To study the dynamic response characteristics of subway stations and superstructures under train loads with a hard combination,a numerical model is developed in this study.The indoor model test verified the accuracy of the numerical model.The influence laws of different hard combinations,train operating speeds and modes were studied and evaluated accordingly.The results show that the frequency corresponding to the peak vibration acceleration level of each floor of the superstructure property is concentrated at 10–20 Hz.The vibration response decreases in the high-frequency parts and increases in the lowfrequency parts with increasing distance from the source.Furthermore,the factors,such as train operating speed,operating mode,and hard combination type,will affect the vibration of the superstructure.The vibration response under the reversible operation of the train is greater than that of the unidirectional operation.The operating speed of the train is proportional to its vibration response.The vibration amplification area appears between the middle and the top of the superstructure at a higher train speed.Its vibration acceleration level will exceed the limit value of relevant regulations,and vibration-damping measures are required.Within the scope of application,this study provides some suggestions for constructing subway stations and superstructures.展开更多
Personalized drug response prediction from molecular data is an important challenge in precision medicine for treating cancer.Computational methods have been widely explored and have become increasingly accurate in re...Personalized drug response prediction from molecular data is an important challenge in precision medicine for treating cancer.Computational methods have been widely explored and have become increasingly accurate in recent years.However,the clinical application of prediction methods is still in its infancy due to large discrepancies between preclinial models and patients.We present a novel disentangled synthesis transfer network(DiSyn)for drug response prediction specifically designed for transfer learning from preclinical models to clinical patients.DiSyn uses a domain separation network(DSN)to disentangle drug response related features,employs data synthesis technology to increase the sample size and iteratively trains for better feature disentanglement.DiSyn is pretrained on large-scale unlabeled cancer samples and validated by three datasets,The Cancer Genome Atlas(TCGA),Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging And moLecular Analysis 2(I-SPY2)and Novartis Institutes for Biomedical Research Patient-Derived Xenograft Encyclopedia(NIBR PDXE),achieving competitive performance with the state-of-the-art methods on cancer patients and mice.Furthermore,the application of DiSyn to thousands of breast cancer patients show the heterogeneity in drug responses and demonstrate its potential value in biomarker discovery and drug combination prediction.展开更多
Macrophages undergo dynamic transitions between M1 and M2 states,exerting profound influences on both inflammatory and regenerative processes.The biocompatible and wound-healing properties of decellularized amniotic m...Macrophages undergo dynamic transitions between M1 and M2 states,exerting profound influences on both inflammatory and regenerative processes.The biocompatible and wound-healing properties of decellularized amniotic membrane(d AM)make it a subject of exploration for its potential impact on the anti-inflammatory response of macrophages.Experimental findings unequivocally demonstrate that d AM promotes anti-inflammatory M2 polarization of macrophage,with its cytokine-rich content posited as a potential mediator.The application of RNA sequencing unveils differential gene expression,implicating the hypoxia inducible factor-1α(HIF-1α)signaling pathway in this intricate interplay.Subsequent investigation further demonstrates that d AM facilitates anti-inflammatory M2 polarization of macrophage through the upregulation of epidermal growth factor(EGF),which,in turn,activates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway and stabilizes HIF-1α.This cascade results in a noteworthy augmentation of anti-inflammatory gene expression.This study significantly contributes to advancing our comprehension of d AM's immunomodulatory role in tissue repair,thereby suggesting promising therapeutic potential.展开更多
基金financially supported by the National Key Research and Development Program of China(Grant No.2023YFC2811600)the National Natural Science Foundation of China(Grant Nos.52301349 and 52088102)+1 种基金the Qingdao Post-Doctorate Science Fund(No.QDBSH20220202070)the Major Scientific and Technological Innovation Project of Shandong Province(Grant No.2019JZZY010820).
文摘A deep-sea mining riser is a crucial component of the system used to lift seafloor mineral resources to the vessel.It is prone to damage and failure because of harsh environmental conditions and internal fluid erosion.Furthermore,damage can impact the response characteristics of the riser,but varying environmental loadings easily mask it.Thus,distin-guishing between riser damage and environmental effects poses a considerable challenge.To address this issue,a cantilevered model is created for a deep-sea mining riser via the concentrated mass method,and a time-domain analytical strategy is developed.The vortex-induced vibration(VIV)response characteristics of the riser are initially examined,considering various damage conditions and flow velocities.The study results revealed four primary observations:(a)effective tension can serve as a reliable indicator for identifying damage at lower velocities;(b)there are noticeable differences in displacement between the healthy and damaged risers in the in-line direction rather than the cross-flow direction;(c)frequency characteristics can more effectively distinguish the damage conditions at high flow velocities,with the mean square frequency and frequency variance being more effective than the centroid frequency and root variance frequency;(d)displacement differences are more sensitive to damage occurring near the top and bottom of the riser,while both velocity variations and structural damage can influence displacements,especially in regions between modal nodes.The vibrational behavior and damage indicators are clarified for structural health monitoring of deep-sea mining risers during lifting operations.
基金Supported by the National Natural Science Foundation of China(No.51905211)A Project of the“20 Regulations for New Universities”Funding Program of Jinan(No.202228116).
文摘Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response of an underwater manipulator subjected to pulsating flow,focusing on how different postures affect the behavior of the system.The effects of pulsating parameters and manipulator arrangement on the hydrodynamic coefficient,vibration response,motion trajectory,and vortex shedding behaviors were analyzed.Results indicated that the cross flow vibration displacement in pulsating flow increased by 32.14%compared to uniform flow,inducing a shift in the motion trajectory from a crescent shape to a sideward vase shape.In the absence of interference between the upper and lower arms,the lift coefficient of the manipulator substantially increased with rising pulsating frequency,reaching a maximum increment of 67.0%.This increase in the lift coefficient led to a 67.05%rise in the vibration frequency of the manipulator in the in-line direction.As the pulsating amplitude increased,the drag coefficient of the underwater manipulator rose by 36.79%,but the vibration frequency in the cross-flow direction decreased by 56.26%.Additionally,when the upper and lower arms remained in a state of mutual interference,the cross-flow vibration amplitudes of the upper and lower arms were approximately 1.84 and 4.82 times higher in a circular-elliptical arrangement compared to an elliptical-circular arrangement,respectively.Consequently,the flow field shifted from a P+S pattern to a disordered pattern,disrupting the regularity of the motion trajectory.
文摘BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.
基金funded by Science and Technology Projects from State Grid Corporation of China,(Research on Adaptive Balance Optimization and Simulation Technology of Industrial community Energy System with High Proportion of Distributed Energy,No.:5100-202355752A-3-4-SY).
文摘To achieve the goals of sustainable development of the energy system and the construction of a lowcarbon society,this study proposes a multi-energy storage collaborative optimization strategy for industrial park that integrates the laddered carbon trading mechanism with demand response.Firstly,a dual dimensional DR model is constructed based on the characteristics of load elasticity.The alternativeDRenables flexible substitution of energy loads through complementary conversion of electricity/heat/cold multi-energy sources,while the price DR relies on timeof-use electricity price signals to guide load spatiotemporal migration;Secondly,the LCT mechanism is introduced to achieve optimal carbon emission costs through a tiered carbon quota allocation mechanism.On this basis,an optimization decision model is established with the core objective of maximizing the annual net profit of the park.The objective function takes into account energy sales revenue,generator unit costs,and investment and operation costs of multiple types of energy storage facilities.Themodel constraint system covers three key dimensions:dynamic operation constraints of power generation units,including unit output limits,ramping capability,and minimum start-stop time;the physical boundary of an electric/hot/cold multi-energy storage system involves energy storage capacity and charge/discharge efficiency;The multi-energy network coupling balance equation ensures that the energy conversion and transmission process satisfies the law of conservation of energy.Using CPLEX mathematical programming solver for simulation verification,construct an energy storage capacity configuration decision process that includes LCT-DR synergistic effect.The research results show that compared with the traditional single energy storage configuration mode,this strategy effectively enhances the economic feasibility and engineering practicality of industrial park operation by coordinating demand side resource scheduling and finely controlling carbon costs,while maintaining stable system operation.Its methodological framework provides a technical path that combines theoretical rigor and practical operability for the low-carbon transformation of regional integrated energy systems.
基金supported by the National Natural Science Foundation of China(Nos.42077367 and 21677123).
文摘Foliar uptake of airborne metal(loid)s plays a crucial role in metal(loid)accumulation in plant organs and is influ-enced by the size and emission sources of aerosols.Given the high enrichment of toxic metal(loid)s in submicron-scale particulates(PM1),this study established a PM1 exposure system to examine airborne metal(loid)accu-mulation and foliar physiological responses in Oryza sativa L.The results showed that the concentrations of Cu,Zn,As,Pb,and Cd in the leaves and grains were influenced not only by the airborne metal(loid)levels but also by the specific nature of the PM1 particles.The quantitative model for PM1-associated Pb entry into leaf tissue indicated that foliar Pb accumulation was primarily driven by particle adhesion,followed by hydrophilic pene-tration and trans-stomatal liquid film migration,accounting for 87%–89%of the total accumulation.The strong hygroscopicity and high Pb activity of PM1 emitted from waste incineration(WI)increased the Pb absorption coefficient via the hydrophilic and liquid film migration pathway.In contrast,the high hydrophobicity of PM1 from coal burning(CB)led to greater retention of Pb on leaf surfaces.Both foliar reactive oxygen metabolism and photosynthesis indices were sensitive to air pollution.Foliar metal(loid)accumulation and airborne PM1 concentration accounted for the variance in physiological responses in rice leaves.Our results also indicated that Pb was the key element in PM1 emissions from both coal burning(CB)and waste incineration(WI)responsible for significant physiological changes in rice leaves.
基金supported by the National Natural Science Foundation of China(Nos.82573045,82460602,82560459)the Hainan Provincial Graduate Student Innovative Research Project(No.Qhys2024-440).
文摘Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immune tolerance of cancer cells.The classical theory holds that prostate apoptosis response-4(PAR-4)is a tumor suppressor protein.However,our recent research has found that PAR-4 has a biological function of promoting cancer in hepatocellular carcinoma(HCC),and our analysis shows that PAR-4 can be modified of lactic acid.These research evidences suggest that PAR-4 lactylation modification may drive immune tolerance in HCC.Therefore,inhibiting PAR-4 lactylation modification is very likely to increase the sensitivity of HCC to immunotherapy.
文摘Based on Iwan′s wake oscillator model developed with the classical van der Pol equation, the differential equation for the response of the vortex-induced vibration (VIV) of the riser considering the effect of the internal flowing fluid and the external marine environmental condition is derived. The effect of the internal flowing fluid on the response of VIV of the riser is studied by means of the Finite Element Method. The results show that the effect of the internal fluid velocity on the VIV of the riser is strong when the natural frequency of the riser is close to the vortex shedding frequency. In addition, the increase of the top tension can decrease the sensitivity of the riser to the internal fluid velocity.
基金supported by the National Natural Science Foundation of China(No.12175102)Hunan Provincial Natural Science Foundation(No.2022JJ40346)the 2022 Hunan Provincial University Student Innovation and Entrepreneurship Training Program(No.S202210555144).
文摘Owing to the inherent limitation of the internal pulse ionization chamber within the AlphaGUARD PQ2000 radon monitor,that is,its inability to discriminate the energy levels of α particles,the ingress of^(220)Rn from the surrounding environment,along with its decay progeny,poses a substantive challenge in accurately determining the^(222)Rn concentration in the measurement outcomes.Among these,the protracted influence primarily stems from the two enduring decay progenies,namely^(212)Pb with a half-life of 10.64 h and^(212)Bi with a half-life of 60.54 min.This study explored the influence of^(220)Rn progeny on the measurement results of an AlphaGUARD PQ2000 radon monitor by developing a theoretical calculation model.The response coefficient related to the residual^(220)Rn progeny within the AlphaGUARD PQ2000 radon monitor was experimentally validated.In addition,this study investigated the effects of temperature and wind speed on the sensitivity of the instrument to^(220)Rn gas.The research findings revealed commendable agreement between the experimentally measured response coefficients of the residual^(220)Rn progeny and the corresponding values derived from the theoretical model.Notably,both the response coefficients of the AlphaGUARD PQ2000 radon monitor to^(220)Rn gas and its internal residual^(220)Rn progeny increased with elevated temperatures and increased wind speeds,providing a reference for correcting the impact of^(220)Rn and its progeny on the measurement results of^(222)Rn concentration obtained using the AlphaGUARD PQ2000 radon monitor.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51909163 and 51979166)。
文摘Vortex-induced vibration(VIV)for flexible cylinders under combined uniform and oscillatory flow is a challenging and practical issue in ocean engineering.In this paper,a time domain numerical model is adopted to investigate the characteristics of cross-flow VIV response and fatigue damage under different combined flow cases.Firstly,the adopted VIV model and fatigue analysis procedure are validated well against the published experimental results of a4-m cylinder model under pure oscillatory flows.Then,forty-five combined flow cases of the same cylinder model are designed to reveal the VIV response characteristics with different non-dimensional oscillation period T^*and combined ratio r.The combined flow cases are classified into three categories to investigate the effect of r on cylinder’s dynamic response,and the effect of T*is described under long and short period cases.Finally,fatigue analysis is carried out to investigate how the structural fatigue damage varies with the variations of r and T^*.The captured characteristics of structural response and fatigue damage are explained through the VIV mechanism analysis.
基金supported by the National Natural Science Foundation of China(No.U2006226)the National Key Research and Development Program of China(No.2016YFC0303800)。
文摘The mechanical behavior,dynamic evolution,and flow-field distribution of a two-degree-of-freedom riserless drill string were simulated numerically by using FLUENT fluid simulation software with the user-defined function embedded.The rotation angular velocities before and after the critical rotation angular velocity were used as independent variables,and the reduced velocity range was 3-14.Fluid-structure coupling was realized based on the dynamic overset grid and the SST k-ωturbulence model.Results reveal that the dynamic response of the riserless drill string was considerably affected by rotation and flow velocity,which are coupled with each other.The cross-flow average dimensionless displacement increased with the rotation angular velocity,and rotation considerably enhanced the in-line maximum average dimensionless displacement.However,the cross-flow amplitude caused by vortex-induced vibration was suppressed when the rotation angular velocity reached a certain value.The in-line and cross-flow frequencies were the same,thereby causing the trajectory to deviate from the standard'figure-eight'shape and become a closed circle shape.The vortex did not fall behind the cylinder at low reduced velocity with high-rotation angular velocity,and the structure of the near-wake vortex remained U-shaped.The wake of the cylinder was deflected along the cross-flow direction,thereby leading to vibration asymmetry and resulting in increased vibration instability and disordered vibration trajectories,especially at high-rotation angular velocities.
基金financially supported by the National Natural Science Foundation of China (Grant Nos. 51979163 and U2106223)。
文摘In offshore engineering, the phenomenon of free span often occurs, and the pipeline may have multiple free spans adjacent to each other, forming a multi-span pipeline. The interaction of different spans makes the structural vibration characteristics more complex, which may change the fatigue characteristics of the pipeline and affect the safety of the structure. In this paper, model tests were designed to explore the vortex-induced vibration(VIV) characteristics of multi-span pipelines and investigate the multi-span interaction mechanism. The experimental study mainly focused on the dynamic response of double-span pipelines, and further extended to triple-span pipelines, hoping that the results can be applied to more complex environment. The effects of span-length ratio, buried depth and axial force on VIV of the pipeline were investigated and discussed. The dynamic response of the pipeline varied with the span length. There was obvious interaction between different spans of multi-span pipelines, and the pipe-sediment interaction obviously affected the vibration characteristics of pipeline. The differences of pipeline burial depth and axial force changed the structural stiffness. With the increase of buried depth, the response amplitude presented a downward trend. The spanwise evolutions were asymmetric caused by the pipe-sediment interaction and multi-span interaction. The results can help to identify multi-span pipelines in engineering, and realize the prevention and control of free spans.
基金supported by the National Key R&D Program of China(No.2022YFB2602800)the National Science Foundation of China(No.51979257)+3 种基金the Basic Funding of the Central Public Research Institutes(Nos.TKS20210101,TKS20220103,TKS20230102)the Fundamental Research Funds for the Central Universities(No.202413018)the postdoctoral project of Shandong(No.SDCX-ZG-202400218)the postdoctoral project of Qingdao(No.QDBSH20240101013).
文摘A three-dimensional numerical scheme was developed to investigate the vortex-induced vibration(VIV)of a catenary-type riser(CTR)in the in-line(IL)and cross-flow(CF)directions.By using the vector form intrinsic finite element method,the CTR was discretized into a finite number of spatial particles whose motions satisfy Newton’s second law.The Van der Pol oscillator was used to simulate the effect of vortex shedding.The coupling equations of structural vibration and wake oscillator were solved using an explicit central differential algorithm.The numerical model was verified with the published results.The VIV characteristics of the CTR subjected to uniform flows,including displacement,frequency,standing wave,traveling wave,motion trajectory,and energy transfer,were studied comprehensively.The numerical results revealed that the multimode property occurs in the CF-and IL-direction VIV responses of the CTR.An increase in the flow velocity has slight effects on the maximum VIV displacement.Due to structural nonlin-earity,the double-frequency relationship in the CF and IL directions is rarely captured.Therefore,the vibration trajectories display the shape of an inclined elliptical orbit.Moreover,the negative energy region is inconspicuous under the excitation of the uniform flow.
基金Supported by the National Natural Science Foundation of China (Grant No. 52222111)the National Science and Technology Major Project of China “Key Technologies and Equipment for Deepwater Dry Oil and Gas Production and Processing Platforms”(No. 2024ZD1403300)+1 种基金Subproject 5 “Research on Safety Risk Assessment Technology System for Deepwater Dry Oil and Gas Production and Processing Platforms”(No. 2024ZD1403305)the China Scholarship Council (202306440019)。
文摘A numerical simulation analysis is conducted to examine the unsteady hydrodynamic characteristics of vortex-induced vibration(VIV)and the suppression effect of helical strakes on VIV in subsea pipelines.The analysis uses the standard k−εturbulence model for 4.5-and 12.75-inch pipes,and its accuracy is verified by comparing the results with large-scale hydrodynamic experiments.These experiments are designed to evaluate the suppression efficiency of VIV with and without helical strakes,focusing on displacement and drag coefficients under different flow conditions.Furthermore,the influence of important geometric parameters of the helical strakes on drag coefficients and VIV suppression efficiency at different flow rates is compared and discussed.Numerical results agree well with experimental data for drag coefficient and vortex shedding frequency.Spring-pipe self-excited vibration experimental tests reveal that the installation of helical strakes substantially reduces the drag coefficient of VIV within a certain flow rate range,achieving suppression efficiencies exceeding 90%with strake heights larger than 0.15D.Notably,the optimized parameter combination of helical strakes,with a pitch of 15D,a fin height of 0.2D,and 45°edge slopes,maintains high suppression efficiency,thereby exhibiting superior performance.This study provides a valuable reference for the design and application of helical strakes and VIV suppression in subsea engineering.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3003805)Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.2022356)Guangzhou Basic and Applied Basic Research Project(Grant No.2023A04J0955).
文摘This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and structural response of the platform are studied,considering the actual platform motion and free surface rise under extreme sea states.First,the effects of the wave frequency and direction on the wave-induced loads and dynamic responses were examined.The motion at a wave direction angle of 0°is relatively low.On this basis,the angle constrained by the two sides of the Sharp Eagle floaters should be aligned with the main wave direction to avoid significant platform motion under extreme sea states.Additionally,the structural response of the platform,including the wave-absorbing floaters,is investigated.The results highlighted that the conditions or locations where yielding,buckling,and fatigue failures occur were different.In this context,the connection area of the Sharp Eagle floaters and platform is prone to yielding failure under oblique wave action,whereas the pontoon and side of the Sharp Eagle floaters are prone to buckling failure during significant vertical motion.Additionally,fatigue damage is most likely to occur at the connection between the middle column on both sides of the Sharp Eagle floaters and the pontoons.The findings of this paper revealed an intrinsic connection between wave-induced loads and the dynamic and structural responses of the platform,which provides a useful reference for the improved design of WECs.
基金supported by National Key R&D Program of China(Grant No.2021YFB2601200)Open Fund of National Engineering Research Center of Highway Maintenance Technology(Changsha University of Science&Technology)(No.kfj230207).
文摘The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and discrete element method(DEM)was employed to investigate the mechanical behavior of asphalt pavement containing a pre-existing TD crack.The mesoscopic parameters of the model were calibrated based on the mixture modulus and the static mechanical response on the MLS66 test road.Finally,an analysis was performed to assess how variations in TD crack depth and longitudinal length affect the distribution patterns of transverse tensile stress,vertical shear stress,and vertical compressive stress.The results indicate that the vertical propagation of TD crack significantly increases both the tensile stress value and range on the middle surface,while the longitudinal development of TD crack has minimal impact.This phenomenon may result in more severe fatigue failure on the middle surface.With the vertical and longitudinal development of TD crack,the vertical shear stress and compressive stress show obvious"two-stage"characteristics.When the crack's vertical length reaches 40 mm,there is a sharp increase in stress on the upper surface.As the crack continues to propagate vertically,the growth of stress on the upper surface becomes negligible,while the stress in the middle and lower layers increased significantly.Conversely,for longitudinal development of TD crack,any changes in stress are insignificant when their length is less than 180 mm;however,as they continue to develop longitudinally beyond this threshold,there is a sharp increase in stress levels.These findings hold great significance for understanding pavement structure deterioration and maintenance behavior associated with TD crack.
文摘BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing models is challenging due to the variety of diseases involved in gastrointestinal surgery and the com-plex factors contributing to patient stress responses.Moreover,stress responses are more severe in older adult patients.Therefore,precision medicine is required to improve the quality of nursing care and promote postoperative recovery in gastrointestinal surgery.and demonstrate nursing benefits through clinical practice.METHODS This randomized clinical trial first established an evidence-based nursing ERAS protocol in older adult patients based on literature related to perioperative nursing measures for gastrointestinal surgery stress response.Next,392 older adult patients who underwent gastrointestinal surgery and were admitted to our hospital between December 2021 and June 2023 were categorized into two groups to receive evidence-based(study group)or conventional(control group)ERAS nursing models,respectively.Intraoperative physiological parameters during surgery and postoperative recovery indicators were compared between the groups.RESULTS Among 64 domestic and international studies,the stress responses of older adult patients mainly included emotional anxiety,sleep disorders,gastrointestinal discomfort,physical weakness,pain,and swelling.The appropriate nursing interventions included comprehensive psychological counseling,pre-and postoperative nutritional support,temperature control,pain management,and rehabilitation training.Compared with the control group,the study group showed lower heart rate,mean arterial pressure,blood glucose level,and adrenaline level;shorter duration of drainage tube placement,time to first flatus,time to first ambulation,and postoperative hospital stay;lower anxiety scores on postoperative day 3;and lower incidences of postoperative infection,obstruction,poor wound healing,and gastrointestinal reactions were lower in the study group(all P<0.05).CONCLUSION The evidence-based nursing measures targeting stress responses based on the conventional ERAS nursing model resulted in stable intraoperative physiological parameters during surgery,promoted postoperative recovery,and reduced the incidence of complications.
文摘The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increased genomic instability and promoting tumor progression.Consequently,targeting DDR mechanisms has emerged as a promising therapeutic strategy in oncology.This review provides an overview of the major DDR pathways,highlighting the roles of key proteins involved in various DDR processes.A detailed understanding of these molecular mechanisms has paved the way for the development of targeted antitumor agents,including inhibitors of PARP1,ATM,ATR,CHK1,CHK2,DNA-PK,and WEE1.Additionally,the significant challenges in the development of DDR inhibitors are examined,including tumor microenvironment heterogeneity,resistance mechanisms,issues with selectivity and toxicity,and the complexities associated with clinical trial design.Finally,future directions and emerging strategies to improve DDR-targeted therapies are discussed.These strategies include biomarker-driven precision medicine,novel combination therapies,advanced drug delivery systems,and the potential application of artificial intelligence to optimize treatment outcomes.
基金National Natural Science Foundation of China under Grant No.51578463。
文摘The vibration response and noise caused by subway trains can affect the safety and comfort of superstructures.To study the dynamic response characteristics of subway stations and superstructures under train loads with a hard combination,a numerical model is developed in this study.The indoor model test verified the accuracy of the numerical model.The influence laws of different hard combinations,train operating speeds and modes were studied and evaluated accordingly.The results show that the frequency corresponding to the peak vibration acceleration level of each floor of the superstructure property is concentrated at 10–20 Hz.The vibration response decreases in the high-frequency parts and increases in the lowfrequency parts with increasing distance from the source.Furthermore,the factors,such as train operating speed,operating mode,and hard combination type,will affect the vibration of the superstructure.The vibration response under the reversible operation of the train is greater than that of the unidirectional operation.The operating speed of the train is proportional to its vibration response.The vibration amplification area appears between the middle and the top of the superstructure at a higher train speed.Its vibration acceleration level will exceed the limit value of relevant regulations,and vibration-damping measures are required.Within the scope of application,this study provides some suggestions for constructing subway stations and superstructures.
基金supported by the National Natural Science Foun-dation of China(Grant Nos.:32170680 and T2122018)the Natural Science Foundation of Shanghai,China(Grant No.:21ZR1476000)the CAS Youth Innovation Promotion Association,China(Grant No.:Y2022076).
文摘Personalized drug response prediction from molecular data is an important challenge in precision medicine for treating cancer.Computational methods have been widely explored and have become increasingly accurate in recent years.However,the clinical application of prediction methods is still in its infancy due to large discrepancies between preclinial models and patients.We present a novel disentangled synthesis transfer network(DiSyn)for drug response prediction specifically designed for transfer learning from preclinical models to clinical patients.DiSyn uses a domain separation network(DSN)to disentangle drug response related features,employs data synthesis technology to increase the sample size and iteratively trains for better feature disentanglement.DiSyn is pretrained on large-scale unlabeled cancer samples and validated by three datasets,The Cancer Genome Atlas(TCGA),Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging And moLecular Analysis 2(I-SPY2)and Novartis Institutes for Biomedical Research Patient-Derived Xenograft Encyclopedia(NIBR PDXE),achieving competitive performance with the state-of-the-art methods on cancer patients and mice.Furthermore,the application of DiSyn to thousands of breast cancer patients show the heterogeneity in drug responses and demonstrate its potential value in biomarker discovery and drug combination prediction.
基金supported by the National Natural Science Foundation of China(No.82302772)Guizhou Basic Research Project(No.ZK[2023]General 201)partially supported by Wuhan Kangchuang Biotechnology Co.,Ltd。
文摘Macrophages undergo dynamic transitions between M1 and M2 states,exerting profound influences on both inflammatory and regenerative processes.The biocompatible and wound-healing properties of decellularized amniotic membrane(d AM)make it a subject of exploration for its potential impact on the anti-inflammatory response of macrophages.Experimental findings unequivocally demonstrate that d AM promotes anti-inflammatory M2 polarization of macrophage,with its cytokine-rich content posited as a potential mediator.The application of RNA sequencing unveils differential gene expression,implicating the hypoxia inducible factor-1α(HIF-1α)signaling pathway in this intricate interplay.Subsequent investigation further demonstrates that d AM facilitates anti-inflammatory M2 polarization of macrophage through the upregulation of epidermal growth factor(EGF),which,in turn,activates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway and stabilizes HIF-1α.This cascade results in a noteworthy augmentation of anti-inflammatory gene expression.This study significantly contributes to advancing our comprehension of d AM's immunomodulatory role in tissue repair,thereby suggesting promising therapeutic potential.
