Chinese ferret badger（FB）-transmitted rabies is a serious threat to public health in southeast China. Although mostly associated with dogs, the rabies virus（RABV） presents genetic diversity and has a significantly...Chinese ferret badger（FB）-transmitted rabies is a serious threat to public health in southeast China. Although mostly associated with dogs, the rabies virus（RABV） presents genetic diversity and has a significantly wide host range in China. Instead of the dog-and wildlife-associated China ⅠI lineage in the past decades, the China Ⅰ lineage has become the main epidemic group hosted and transmitted by dogs. In this study, four new lineages, including 43 RABVs from FBs, have been classified within the dog-dominated China Ⅰ lineage since 2014. FBRABVs have been previously categorized in the China Ⅱ lineage. Moreover, FB-hosted viruses seem to have become the main independent FB-associated clade in the phylogenetic tree. This claim suggests that the increasing genetic diversity of RABVs in FBs is a result of the selective pressure from coexisting dog rabies. FB transmission has become complicated and serious with the coexistence of dog rabies. Therefore, apart from targeting FB rabies, priority should be provided by the appropriate state agencies to perform mass immunization of dog against rabies.展开更多
Objective:To analyze factors affecting the utilization of human immunodeficiency virus counseling and testing(HCT)service among human immunodeficiency virus risk groups at Hessa Air Genting Health Center,Asahan Regenc...Objective:To analyze factors affecting the utilization of human immunodeficiency virus counseling and testing(HCT)service among human immunodeficiency virus risk groups at Hessa Air Genting Health Center,Asahan Regency,North Sumatera,Indonesia.Methods:This quantitative unmatched case-control study was conducted from April 2024 to April 2025 at Hessa Air Genting Health Center,Asahan Regency,North Sumatra Province,Indonesia.Female sex workers and men who have sex with men were selected using purposive sampling based on predefined inclusion and exclusion criteria.Data were collected via questionnaires and analyzed using SPSS version 18.0,with univariate analysis,bivariate analysis(Chi-square test),and multivariate analysis(logistic regression analysis).Results:Comprehensive analysis of 75 cases and 75 controls was conducted to identify factors affecting the utilization of HCT services.Specifically,this study identified significant effects of knowledge(OR 3.2,95%CI 1.5-7.0,P=0.003),perception(OR 5.6,95%CI 2.5-12.5,P<0.001),information media(OR 3.1,95%CI 1.4-6.8,P=0.005),and health workers encouragement(OR 4.0,95%CI 1.5-10.4,P=0.005).In contrast,access to health services did not have a significant effect.Conclusions:Knowledge,perception,information media,and health worker encouragement had significant effects on HCT service utilization,with perception identified as the dominant factor.To improve utilization,strengthening positive perceptions,targeted training for healthcare workers,strengthened partnerships with local non-governmental organizations,and the use of social media for health promotion are recommended.展开更多
基金supported by the National Key Research and Development Program of China[2016YFD0500401,2016YFD0501000,2017YFD0502300,and 2017YFD0500600]
文摘Chinese ferret badger（FB）-transmitted rabies is a serious threat to public health in southeast China. Although mostly associated with dogs, the rabies virus（RABV） presents genetic diversity and has a significantly wide host range in China. Instead of the dog-and wildlife-associated China ⅠI lineage in the past decades, the China Ⅰ lineage has become the main epidemic group hosted and transmitted by dogs. In this study, four new lineages, including 43 RABVs from FBs, have been classified within the dog-dominated China Ⅰ lineage since 2014. FBRABVs have been previously categorized in the China Ⅱ lineage. Moreover, FB-hosted viruses seem to have become the main independent FB-associated clade in the phylogenetic tree. This claim suggests that the increasing genetic diversity of RABVs in FBs is a result of the selective pressure from coexisting dog rabies. FB transmission has become complicated and serious with the coexistence of dog rabies. Therefore, apart from targeting FB rabies, priority should be provided by the appropriate state agencies to perform mass immunization of dog against rabies.
文摘Objective:To analyze factors affecting the utilization of human immunodeficiency virus counseling and testing(HCT)service among human immunodeficiency virus risk groups at Hessa Air Genting Health Center,Asahan Regency,North Sumatera,Indonesia.Methods:This quantitative unmatched case-control study was conducted from April 2024 to April 2025 at Hessa Air Genting Health Center,Asahan Regency,North Sumatra Province,Indonesia.Female sex workers and men who have sex with men were selected using purposive sampling based on predefined inclusion and exclusion criteria.Data were collected via questionnaires and analyzed using SPSS version 18.0,with univariate analysis,bivariate analysis(Chi-square test),and multivariate analysis(logistic regression analysis).Results:Comprehensive analysis of 75 cases and 75 controls was conducted to identify factors affecting the utilization of HCT services.Specifically,this study identified significant effects of knowledge(OR 3.2,95%CI 1.5-7.0,P=0.003),perception(OR 5.6,95%CI 2.5-12.5,P<0.001),information media(OR 3.1,95%CI 1.4-6.8,P=0.005),and health workers encouragement(OR 4.0,95%CI 1.5-10.4,P=0.005).In contrast,access to health services did not have a significant effect.Conclusions:Knowledge,perception,information media,and health worker encouragement had significant effects on HCT service utilization,with perception identified as the dominant factor.To improve utilization,strengthening positive perceptions,targeted training for healthcare workers,strengthened partnerships with local non-governmental organizations,and the use of social media for health promotion are recommended.
