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基于NV色心的钢轨裂纹检测分析
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作者 范华林 史红兵 +9 位作者 赵博文 董亮亮 程江辉 王仁涛 谢赛南 张鸣山 肖久华 张少春 沈忆华 周梦良 《无损检测》 2026年第1期70-73,79,共5页
目前大多使用人工检测和超声检测对钢轨进行在线检测,钢轨裂纹宽度及深度的检测精度为毫米级,对开口小、深度浅的微米级钢轨裂纹尚未有合适的检测方法。针对此不足,提出基于金刚石氮-空位(Nitrogen-vacancy,NV)色心的钢轨裂纹检测方法,... 目前大多使用人工检测和超声检测对钢轨进行在线检测,钢轨裂纹宽度及深度的检测精度为毫米级,对开口小、深度浅的微米级钢轨裂纹尚未有合适的检测方法。针对此不足,提出基于金刚石氮-空位(Nitrogen-vacancy,NV)色心的钢轨裂纹检测方法,并研制相应的漏磁-量子检测装置。针对钢轨表面的裂纹,使用永磁铁磁化钢轨表面,通过NV色心对磁的高灵敏度和高分辨率特性检测钢轨表面裂纹漏磁信号。选取锰钢钢轨,在表面设计并加工横向裂纹,配合设计的钢轨探伤车进行检测试验。试验结果表明,试验装置的测量灵敏度为7nT/√Hz,可以完成最小宽度为100 um,深度为100 um的钢轨表面裂纹检测。 展开更多
关键词 钢轨 裂纹检测 漏磁检测 nv色心
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用于金刚石NV色心量子磁强计的集成化光电系统研究
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作者 戴雨霖 徐南阳 田宇 《合肥工业大学学报(自然科学版)》 北大核心 2026年第1期62-66,101,共6页
基于金刚石的磁测量系统因其稳定性、矢量性和常温光学读出等性质,具有广泛的应用前景,而激光器和光电探测器是金刚石电子自旋量子态操控和读出的关键器件,其性能直接决定磁强计的灵敏度。文章设计了一套为金刚石氮空位(nitrogen-vacanc... 基于金刚石的磁测量系统因其稳定性、矢量性和常温光学读出等性质,具有广泛的应用前景,而激光器和光电探测器是金刚石电子自旋量子态操控和读出的关键器件,其性能直接决定磁强计的灵敏度。文章设计了一套为金刚石氮空位(nitrogen-vacancy,NV)色心磁强计定制的集成光电系统,包含超小型激光控制和光电探测模块。激光控制模块基于TPS54200芯片实现,输出光强可达700 mW;光电探测模块采用S13955-01光电二极管与AD8065运算放大器实现;两模块实物性能与商用器件相近,但结构更简单,体积和功耗显著降低。基于该集成系统,最终研制的小型化金刚石NV色心量子磁强计实现了nT/Hz^(1/2)量级的灵敏度,大幅超越此前μT/Hz^(1/2)量级的工作成果,有望应用于航空磁探等领域。 展开更多
关键词 金刚石 氮空位(nv)色心 磁强计 集成光电系统 激光控制 光电探测
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An investigation of nursing practices and processes and patient experiences in relation to virtual outpatient clinics in an acute care hospital–considerations for nurse managers
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作者 Elaine Harris Marian Hayden +4 位作者 Joanna Rea Patricia White Margaret McCann Leona Connolly Catherine McCabe 《Frontiers of Nursing》 2026年第1期33-42,共10页
Objective:Nurse-led virtual outpatient clinics are now a familiar component of healthcare delivery across many disciplines,including cancer care,or thopedics,rheumatology,and gastroenterology.However,establishing a nu... Objective:Nurse-led virtual outpatient clinics are now a familiar component of healthcare delivery across many disciplines,including cancer care,or thopedics,rheumatology,and gastroenterology.However,establishing a nurse-led vir tual clinic is challenging for nursing management,par ticularly regarding resources.We aimed to investigate nursing practices and processes and patient experiences in relation to vir tual outpatient clinics.Methods:This was a cross-sectional,descriptive study using mixed data collection methods.Patients(n=324)from 4 specialist clinics completed the Virtual Clinics Patient Satisfaction Questionnaire(VCSQ)survey.Five Nurse Specialists participated in a focus group interview.Results:Most participants(86.3%)reported being satisfied/very satisfied with the virtual clinics,particularly those that were nurse-led.Nurse specialists identified electronic health records(EHRs)and additional IT and administrative support as important for efficiency and effectiveness of the clinics.Conclusions:Nurse-led virtual clinics can be an effective and efficient way to provide care to patients.Nurse managers need to ensure supportive structures are in place,for example,dedicated administrators,IT support and infrastructure,education/training,and relevant policies/procedures.The success of nurse-led virtual services requires key infrastructure to support nursing staff and sustain this service. 展开更多
关键词 nursing informatics nursing management patient experiences virtual care remote health
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Revealing the potential geographic convergence of global water scarcity risk and virtual water trade inequality:A three-module integrated analytical approach
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作者 Qiting Zuo Zhizhuo Zhang +2 位作者 Junxia Ma Qingsong Wu Yihu Ji 《Geography and Sustainability》 2026年第1期141-154,共14页
Unequal virtual water transfer may aggravate local water scarcity risk.However,the quantitative confirmation of a clear geographic convergence between virtual water transfer and water scarcity risk remains undetermine... Unequal virtual water transfer may aggravate local water scarcity risk.However,the quantitative confirmation of a clear geographic convergence between virtual water transfer and water scarcity risk remains undetermined.We present an analytical framework that reveals the spatial matching between global water scarcity risk and virtual water trade inequality.This framework integrates a three-dimensional water scarcity risk assessment,hybrid input-output analysis,pollution trade term construction,and geographic convergence identification.The framework is applied to 123 countries for long-term validation from 1991 to 2021.We show that despite global improvements in water efficiency and security,countries exceeding the maximum water vulnerability threshold have increased by 50%.South Asia is the largest net exporter of virtual water.Central Asia exhibits the most pronounced virtual water trade inequality.To achieve the same economic growth,Central Asia needs to pay several times the local water consumption costs of developed regions(15.9−83.6 times,2021).In the past 30 years,the average geographic convergence index exceeded 0.8.Countries facing severe water scarcity also exhibit pronounced inequalities in virtual water trade,indicating that a significant geographic convergence relationship exists.Effectively responding to this unsustainable relationship necessitates balancing both domestic resource risk management and global virtual water trade regulation. 展开更多
关键词 Water scarcity risk Virtual water transfer Global inequity Geographic convergence Water resources management
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Formulating an Innovative Gamified Personalized Learning Ecosystem Integrating 3D/VR Environments,Machine Learning,and Business Intelligence
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作者 Nymfodora-Maria Raftopoulou Petros L.Pallis 《Sociology Study》 2026年第1期13-32,共20页
Latest digital advancements have intensified the necessity for adaptive,data-driven and socially-centered learning ecosystems.This paper presents the formulation of a cross-platform,innovative,gamified and personalize... Latest digital advancements have intensified the necessity for adaptive,data-driven and socially-centered learning ecosystems.This paper presents the formulation of a cross-platform,innovative,gamified and personalized Learning Ecosystem,which integrates 3D/VR environments,as well as machine learning algorithms,and business intelligence frameworks to enhance learner-centered education and inferenced decision-making.This Learning System makes use of immersive,analytically assessed virtual learning spaces,therefore facilitating real-time monitoring of not just learning performance,but also overall engagement and behavioral patterns,via a comprehensive set of sustainability-oriented ESG-aligned Key Performance Indicators(KPIs).Machine learning models support predictive analysis,personalized feedback,and hybrid recommendation mechanisms,whilst dedicated dashboards translate complex educational data into actionable insights for all Use Cases of the System(Educational Institutions,Educators and Learners).Additionally,the presented Learning System introduces a structured Mentoring and Consulting Subsystem,thence reinforcing human-centered guidance alongside automated intelligence.The Platform’s modular architecture and simulation-centered evaluation approach actively support personalized,and continuously optimized learning pathways.Thence,it exemplifies a mature,adaptive Learning Ecosystem,supporting immersive technologies,analytics,and pedagogical support,hence,contributing to contemporary digital learning innovation and sociotechnical transformation in education. 展开更多
关键词 gamified learning ecosystems learning analytics business intelligence personalized education virtual reality machine learning
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Design of Virtual Driving Test Environment for Collecting and Validating Bad Weather SiLS Data Based on Multi-Source Images Using DCU with V2X-Car Edge Cloud
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作者 Sun Park JongWon Kim 《Computers, Materials & Continua》 2026年第3期448-467,共20页
In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to... In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to dangerous situations.Furthermore,autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS.Driving simulators,which replicate driving conditions nearly identical to those in the real world,can drastically reduce the time and cost required for market entry validation;consequently,they have become widely used.In this paper,we design a virtual driving test environment capable of collecting and verifying SiLS data under adverse weather conditions using multi-source images.The proposed method generates a virtual testing environment that incorporates various events,including weather,time of day,and moving objects,that cannot be easily verified in real-world autonomous driving tests.By setting up scenario-based virtual environment events,multi-source image analysis and verification using real-world DCUs(Data Concentrator Units)with V2X-Car edge cloud can effectively address risk factors that may arise in real-world situations.We tested and validated the proposed method with scenarios employing V2X communication and multi-source image analysis. 展开更多
关键词 Virtual driving test DCU bad weather SiLS autonomous environment V2X-Car edge cloud
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褒贬反转构式“这NV的”的语篇承继关联及话语功能
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作者 朱敏 《语文学刊》 2025年第1期60-68,共9页
“这NV的”是一个将积极义和消极义集于一身的主观评价构式。它表示积极评价时是有标记的,而表示消极评价时是无标记的。从语篇承继关联的角度看,“这NV的”的语义整合可以分为四级,从低整合度到高整合度的承继过程体现了“渐变性”特... “这NV的”是一个将积极义和消极义集于一身的主观评价构式。它表示积极评价时是有标记的,而表示消极评价时是无标记的。从语篇承继关联的角度看,“这NV的”的语义整合可以分为四级,从低整合度到高整合度的承继过程体现了“渐变性”特征。补语的脱落、前景提示的消失、积极义的有标记性和消极义的无标记性都体现了语言经济性的特点。说话人使用“这NV的”来凸显某事态的主观超量特征,并体现出说话人爱憎分明的评价特点,表达出委婉含蓄的言外之意。 展开更多
关键词 “这nv的” 承继 理据 话语功能 语言经济性
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面向NV色心宽带微波传感系统的天线设计 被引量:2
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作者 柯冬倩 武炳地 马宗敏 《传感器与微系统》 北大核心 2025年第4期78-82,共5页
宽频带微波探测在无线通信、遥感以及医学成像等领域至关重要。金刚石氮-空位(NV)色心因其高稳定性和高灵敏度等优势成为微波检测的热门选择。但现在用于NV传感器的天线存在信号传输质量差和频带窄等问题。本文设计了多谐振频率环形天线... 宽频带微波探测在无线通信、遥感以及医学成像等领域至关重要。金刚石氮-空位(NV)色心因其高稳定性和高灵敏度等优势成为微波检测的热门选择。但现在用于NV传感器的天线存在信号传输质量差和频带窄等问题。本文设计了多谐振频率环形天线组,结合宽场成像技术与光学探测磁场共振(ODMR)技术构建了金刚石微波频谱检测系统,对磁场引起的ODMR共振频率的偏移进行空间编码进而探测微波。实验结果表明:所设计的天线组在增强电子自旋共振(ESR)对比度方面表现优异,达到13%,比传统宽频带螺旋天线提高了5.5%,并实现了2.2~10.0 GHz范围的微波频谱检测。该设计为NV量子传感器多频段微波探测技术的发展提供了新思路。 展开更多
关键词 nv色心 宽带天线 微波检测 量子传感
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A Trusted Mobile Payment Environment Based on Trusted Computing and Virtualization Technology 被引量:2
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作者 WANG Juan LIN Wutao +3 位作者 LI Haoyu DU Bianxia MENG Ke WANG Jiang 《Wuhan University Journal of Natural Sciences》 CAS 2014年第5期379-384,共6页
In this paper, we propose a trusted mobile payment environment (TMPE) based on trusted computing and virtualization technology. There are a normal operating system (OS) and a trusted OS (TOS) in TMPE. We store t... In this paper, we propose a trusted mobile payment environment (TMPE) based on trusted computing and virtualization technology. There are a normal operating system (OS) and a trusted OS (TOS) in TMPE. We store the image of TOS in a memory card to hinder tampering. The integrity of TOS is protected by means of a trusted platform module (TPM). TOS can only be updated through a trusted third party. In addition, virtualization technology is applied to isolate TOS from normal OS. Users complete ordinary affairs in normal OS and security-sensitive affairs in TOS. TMPE can offer users a highly protected environment for mobile payment. Moreover, TMPE has good compatibility in different hardware architectures of mobile platforms. As the evaluation shows, TMPE satisfies the requirement of mobile payment well. 展开更多
关键词 trusted computing mobile payment virtualization mobile platform
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Security Challenges of Virtualization Hypervisors in Virtualized Hardware Environment 被引量:1
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作者 Gabriel Cephas Obasuyi Arif Sari 《International Journal of Communications, Network and System Sciences》 2015年第7期260-273,共14页
The concept of virtualization machines is not new, but it is increasing vastly and gaining popularity in the IT world. Hypervisors are also popular for security as a means of isolation. The virtualization of informati... The concept of virtualization machines is not new, but it is increasing vastly and gaining popularity in the IT world. Hypervisors are also popular for security as a means of isolation. The virtualization of information technology infrastructure creates the enablement of IT resources to be shared and used on several other devices and applications;this increases the growth of business needs. The environment created by virtualization is not restricted to any configuration physically or execution. The resources of a computer are shared logically. Hypervisors help in virtualization of hardware that is a software interact with the physical system, enabling or providing virtualized hardware environment to support multiple running operating system simultaneously utilizing one physical server. This paper explores the benefits, types and security issues of Virtualization Hypervisor in virtualized hardware environment. 展开更多
关键词 virtualization Hypervisors VIRTUAL MACHINE VIRTUAL MACHINE MONITOR SECURITY
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基于频率调制参数优化的高灵敏NV色心磁测量技术研究
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作者 郑斗斗 王珲 +3 位作者 高健 李洋 杨应杰 马宗敏 《量子光学学报》 北大核心 2025年第1期33-41,共9页
金刚石氮空位(NV)色心在磁场测量领域展现出显著的高灵敏度和高分辨率等优势。为了解决传统的光探测磁共振(ODMR)方法无法实现待测磁场高灵敏度实时检测等问题,近年来基于微波频率调制技术的NV色心磁测量方法受到广泛关注和研究,然而最... 金刚石氮空位(NV)色心在磁场测量领域展现出显著的高灵敏度和高分辨率等优势。为了解决传统的光探测磁共振(ODMR)方法无法实现待测磁场高灵敏度实时检测等问题,近年来基于微波频率调制技术的NV色心磁测量方法受到广泛关注和研究,然而最优调制频率和调制频偏参数不明晰成为了限制NV色心磁强计灵敏度的重要因素之一。本文通过建立解调信号模型,结合仿真得到了理论最优调制频偏参数。经过实验验证,得到最佳调制频率参数为500 Hz及1 kHz至2 kHz范围,调制频偏为8 MHz,由于色心浓度及微波不均匀导致的共振谱展宽限制了其与理论结果的匹配度,但调制频偏参数的变化趋势在仿真和实验结果中表现一致。本研究为NV色心磁强计的灵敏度指标提升提供了理论指导和实验经验。 展开更多
关键词 nv色心 调制频率 调制频偏 灵敏度
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金刚石中的NV色心制备和应用研究
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作者 伍正新 满卫东 +4 位作者 贾元波 梁凯 范冰庆 付萍 赵洪阳 《广州化工》 2025年第6期45-48,共4页
金刚石中的氮空位(NV)中心是一种固态缺陷量子比特,在室温下具有良好的相干时间,可用于多种量子传感器和生物领域的应用。在量子计算和通信中也具有潜在的应用价值。量子控制在很大程度上取决于NV中心的电子结构和状态的复杂细节,这些... 金刚石中的氮空位(NV)中心是一种固态缺陷量子比特,在室温下具有良好的相干时间,可用于多种量子传感器和生物领域的应用。在量子计算和通信中也具有潜在的应用价值。量子控制在很大程度上取决于NV中心的电子结构和状态的复杂细节,这些状态之间的辐射和非辐射速率,以及这些状态与外部自旋、电场、磁场和应变场以及温度的耦合。近年来,量子传感器测温的灵敏度随着NV色心制备工艺的优化而得到巨大提升,在显微成像领域也取得很大成果。本文首先介绍了NV色心的结构和基本特性,并对其制备方法和应用研究进行了总结。 展开更多
关键词 金刚石 nv色心 量子比特 量子传感
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基于 NV 色心的弱磁场扫描成像实验
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作者 袁竟程 王涛 +2 位作者 张军伟 刘心宇 杜关祥 《佳木斯大学学报(自然科学版)》 2025年第2期174-176,33,共4页
为适应当下芯片复杂度、集成度提升的发展趋势,亟需一种高分辨精密磁场成像系统。基于NV色心实现的新式磁场扫描系统可在室温下完成高分辨率、高灵敏度的弱磁场扫描成像,且测量过程不产生电磁干扰,填补了传统磁场测量技术的空白。设计... 为适应当下芯片复杂度、集成度提升的发展趋势,亟需一种高分辨精密磁场成像系统。基于NV色心实现的新式磁场扫描系统可在室温下完成高分辨率、高灵敏度的弱磁场扫描成像,且测量过程不产生电磁干扰,填补了传统磁场测量技术的空白。设计了两个基于NV色心的弱磁场扫描实验,以期为NV色心磁场扫描成像装置的研发提供参考。 展开更多
关键词 nv色心 磁成像 脉冲光探测磁共振 拉比振荡
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Resource Virtualization Model Using Hybrid-graph Representation and Converging Algorithm for Cloud Computing
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作者 Quan Liang Yuan-Zhuo Wang Yong-Hui Zhang 《International Journal of Automation and computing》 EI CSCD 2013年第6期597-606,共10页
Cloud computing can provide a great capacity for massive computing, storage as well as processing. The capacity comes from the cloud computing system itself, which can be likened to a virtualized resource pool that su... Cloud computing can provide a great capacity for massive computing, storage as well as processing. The capacity comes from the cloud computing system itself, which can be likened to a virtualized resource pool that supports virtualization applications as well as load migration. Based on the existing technologies, the paper proposes a resource virtualization model (RVM) utilizing a hybrid-graph structure. The hybrid-graph structure can formally represent the critical entities such as private clouds, nodes within the private clouds, and resource including its type and quantity. It also provides a clear description of the logical relationship and the dynamic expansion among them as well. Moreover, based on the RVM, a resource converging algorithm and a maintaining algorithm of the resource pool which can timely reflect the dynamic variation of the private cloud and resource are presented. The algorithms collect resources and put them into the private cloud resource pools and global resource pools, and enable a real-time maintenance for the dynamic variation of resource to ensure the continuity and reliability. Both of the algorithms use a queue structure to accomplish functions of resource converging. Finally, a simulation platform of cloud computing is designed to test the algorithms proposed in the paper. The results show the correctness and the reliability of the algorithms. 展开更多
关键词 Cloud computing resource virtualization hybrid graph resource converging simulation.
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金刚石NV-色心中近红外光对自旋电荷态转换的影响研究
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作者 胡钧 钱鹏 +2 位作者 张恒 张杨 马钰 《合肥工业大学学报(自然科学版)》 北大核心 2025年第8期1112-1116,共5页
文章利用近红外光对532 nm激光照射金刚石氮空位(nitrogen-vacancy,NV)色心产生的荧光时间轨迹进行调制,发现不同电子自旋初态下的调制深度并不相同;由于589 nm激光只激发处于负电性电荷态的色心(NV-色心),进而研究不同功率的589 nm激... 文章利用近红外光对532 nm激光照射金刚石氮空位(nitrogen-vacancy,NV)色心产生的荧光时间轨迹进行调制,发现不同电子自旋初态下的调制深度并不相同;由于589 nm激光只激发处于负电性电荷态的色心(NV-色心),进而研究不同功率的589 nm激光单独激发色心和加入近红外光共同激发色心导致的电荷态布居变化。实验结果表明,近红外光能够加快NV-色心电离的过程,但是不同电子自旋初态导致的电离速率有所差异,造成该差异的原因可能是近红外光对NV-色心自旋单态的电离比激发态的电离具有更高的效率。文章研究结果对基于金刚石NV-色心的自旋量子态读出和量子精密测量具有重要意义。 展开更多
关键词 氮空位(nv)色心 电荷态 近红外光 自旋态
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Investigating the Implications of Virtualization for Digital Forensics
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作者 Song Zheng Jin Bo +1 位作者 Zhu Yinghong Sun Yongqing 《China Communications》 SCIE CSCD 2010年第6期100-106,共7页
Research in virtualization technology has gained significant developments in recent years, which brings not only opportunities to the forensic community, but challenges as well. This paper discusses the potential role... Research in virtualization technology has gained significant developments in recent years, which brings not only opportunities to the forensic community, but challenges as well. This paper discusses the potential roles of virtualization in digital forensics, examines the recent progresses which use the virtualization techniques to support modem computer forensics. The influences on digital forensics caused by virtualization technology are identified. Tools and methods in common digital forensic practices are analyzed, and experiences of our practice and reflections in this field are shared. 展开更多
关键词 digital forensics virtualization forensic image booting virtual machine introspection
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基于金刚石NV色心系综的电子自旋能级测量
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作者 于同坡 林辉 +3 位作者 范经纬 张霆 李中军 陈冰 《大学物理》 2025年第12期9-15,28,共8页
本文设计并实现了一种基于NV色心系综的量子化能级测量实验装置,结合光探测磁共振(ODMR)技术,相较于传统电子自旋共振(ESR)实验依赖的大功率微波源与高灵敏度探测器,本方案通过纳米金刚石团簇与共聚焦显微系统,实现了低成本高灵敏度测量... 本文设计并实现了一种基于NV色心系综的量子化能级测量实验装置,结合光探测磁共振(ODMR)技术,相较于传统电子自旋共振(ESR)实验依赖的大功率微波源与高灵敏度探测器,本方案通过纳米金刚石团簇与共聚焦显微系统,实现了低成本高灵敏度测量.通过使用纳米金刚石团簇增强荧光信号,结合共聚焦显微系统与微波扫频技术,实现了室温下电子自旋能级的塞曼效应及温度响应观测.本实验方案适用于大学物理教学,可帮助学生理解量子能级测量原理及固态量子传感技术. 展开更多
关键词 量子化能级 nv色心 光探测磁共振 塞曼效应 教学实验
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A Concurrent Security Monitoring Method for Virtualization Environments
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作者 TIAN Donghai JIA Xiaoqi +1 位作者 CHEN Junhua HU Changzhen 《China Communications》 SCIE CSCD 2016年第1期113-123,共11页
Recently,virtualization technologies have been widely used in industry.In order to monitor the security of target systems in virtualization environments,conventional methods usually put the security monitoring mechani... Recently,virtualization technologies have been widely used in industry.In order to monitor the security of target systems in virtualization environments,conventional methods usually put the security monitoring mechanism into the normal functionality of the target systems.However,these methods are either prone to be tempered by attackers or introduce considerable performance overhead for target systems.To address these problems,in this paper,we present a concurrent security monitoring method which decouples traditional serial mechanisms,including security event collector and analyzer,into two concurrent components.On one hand,we utilize the SIM framework to deploy the event collector into the target virtual machine.On the other hand,we combine the virtualization technology and multi-core technology to put the event analyzer into a trusted execution environment.To address the synchronization problem between these two concurrent components,we make use of Lamport's ring buffer algorithm.Based on the Xen hypervisor,we have implemented a prototype system named COMO.The experimental results show that COMO can monitor the security of the target virtual machine concurrently within a little performance overhead. 展开更多
关键词 security virtualization technology concurrent monitoring
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Unveiling and swift diagnosing chronic wound healing with artificial intelligence assistance 被引量:1
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作者 Jiliang Deng Guoliang Shi +5 位作者 Zhihang Ye Quan Xiao Xiaoting Zhang Lei Ren Fangyu Yang Miao Wang 《Chinese Chemical Letters》 2025年第3期469-475,共7页
Histopathological analysis of chronic wounds is crucial for clinicians to accurately assess wound healing progress and detect potential malignancy.However,traditional pathological tissue sections require specific stai... Histopathological analysis of chronic wounds is crucial for clinicians to accurately assess wound healing progress and detect potential malignancy.However,traditional pathological tissue sections require specific staining procedures involving carcinogenic chemicals.This study proposes an interdisciplinary approach merging materials science,medicine,and artificial intelligence(AI)to develop a virtual staining technique and intelligent evaluation model based on deep learning for chronic wound tissue pathology.This innovation aims to enhance clinical diagnosis and treatment by offering personalized AI-driven therapeutic strategies.By establishing a mouse model of chronic wounds and using a series of hydrogel wound dressings,tissue pathology sections were periodically collected for manual staining and healing assessment.We focused on leveraging the pix2pix image translation framework within deep learning networks.Through CNN models implemented in Python using PyTorch,our study involves learning and feature extraction for region segmentation of pathological slides.Comparative analysis between virtual staining and manual staining results,along with healing diagnosis conclusions,aims to optimize AI models.Ultimately,this approach integrates new metrics such as image recognition,quantitative analysis,and digital diagnostics to formulate an intelligent wound assessment model,facilitating smart monitoring and personalized treatment of wounds.In blind evaluation by pathologists,minimal disparities were found between virtual and conventional histologically stained images of murine wound tissue.The evaluation used pathologists’average scores on real stained images as a benchmark.The scores for virtual stained images were 71.1%for cellular features,75.4%for tissue structures,and 77.8%for overall assessment.Metrics such as PSNR(20.265)and SSIM(0.634)demonstrated our algorithms’superior performance over existing networks.Eight pathological features such as epidermis,hair follicles,and granulation tissue can be accurately identified,and the images were found to be more faithful to the actual tissue feature distribution when compared to manually annotated data. 展开更多
关键词 Chronic wound Virtual pathological staining AI-assisted diagnostic and therapeutic Gel dressings
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Three-dimensional localization of the individual shallow NV center in diamond using a gold tip
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作者 Jiarui Qi Xinghang Chen +1 位作者 Mengqi Wang Ya Wang 《中国科学技术大学学报》 北大核心 2025年第4期35-39,34,I0002,共7页
This work presents a method for the three-dimensional localization of individual shallow NV center in diamond,leveraging the near-field quenching effect of a gold tip.Our experimental setup involves the use of an atom... This work presents a method for the three-dimensional localization of individual shallow NV center in diamond,leveraging the near-field quenching effect of a gold tip.Our experimental setup involves the use of an atomic force microscope to precisely move the gold tip close to the NV center,while simultaneously employing a home-made confocal microscope to monitor the fluorescence of the NV center.This approach allows for lateral super-resolution,achieving a full width at half maximum(FWHM)of 38.0 nm and a location uncertainty of 0.7 nm.Additionally,we show the potential of this method for determining the depth of the NV centers.We also attempt to determine the depth of the NV centers in combination with finite-difference time-domain(FDTD)simulations.Compared to other depth determination methods,this approach allows for simultaneous lateral and longitudinal localization of individual NV centers,and holds promise for facilitating manipulation of the local environment surrounding the NV center. 展开更多
关键词 nv center super-resolution localization atom force microscopy
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