Scopus recently releasedits 2024CiteScore metrics.The 2024 CiteScore for Animal Diseases is 3.6,representing a 50%increase compared to 2023.The journal's ranking has risen significantly:It ranks 38th out of 200 jo...Scopus recently releasedits 2024CiteScore metrics.The 2024 CiteScore for Animal Diseases is 3.6,representing a 50%increase compared to 2023.The journal's ranking has risen significantly:It ranks 38th out of 200 journals in the Veterinary category,marking the 81%and placing it in the Q1 zone.Simultaneously,it ranks 110th out of 509 journals in the Animal Science and Zoology category,placing it at the 78%and also within the Q1 zone.展开更多
[Objective]To screen sensitive drugs and their combinations against biofilm formation of Escherichia coli isolated from Tibetan pigs and Tibetan chickens.[Method]Semi-quantitative modified crystal violet staining and ...[Objective]To screen sensitive drugs and their combinations against biofilm formation of Escherichia coli isolated from Tibetan pigs and Tibetan chickens.[Method]Semi-quantitative modified crystal violet staining and the micro broth dilution method were employed to assess the biofilm-forming capacities of 152 E.coli,and their susceptibility to 12 commonly used antibiotics.Meanwhile,the checkerboard testing method was employed to evaluate the combined antibacterial activity of the sequential solvent fractions(methanol,dichloromethane,ethyl acetate,and petroleum ether)from four Tibetan veterinary medicinal plants(Spenceria ramalana Trimen,Thalictrum delawayi Franch.,Gentiana sino-ornata Balf.f.,Lonicera rupicola Hook.f.&Thomson),the ethyl acetate extract of two Enterococcus faecium and antibiotics with high resistance rates[chloramphenicol(CHL),oxytetracycline(OTC),ampicillin(AMP),and sulfamethoxazole(SMZ)]against ten selected multi-drug resistant E.coli(designated E1-E10).Lastly,the biofilm eradication of drug combinations on biofilms of E.coli E6 was examined.[Result]Most of the 152 E.coli exhibited moderate and no biofilm-forming capacities.The resistance rates to CHL,sulfamethazine(SM2),OTC,AMP,and SMZ exceeded 90%.In contrast,the resistance rates to difloxacin(DIF),ciprofloxacin(CIP),amikacin(AMK),ceftiofur(EFT),tobramycin(TOB),and ceftriaxone(CTR)were below 50%.Notably,the strains demonstrated a higher susceptibility to amikacin,with a drug resistance rate of only 19.90%.The MIC values for the E.coli E1-E10 were observed to range from 3.93 to 15.63 mg/mL for the methanol extract of S.ramalana,3.93 to 31.52 mg/mL for the ethyl acetate extract of T.delavayi,7.81 to 15.63 mg/mL for the methanol extract of G.sino-ornata,and 7.81 to 31.52 mg/mL for the ethyl acetate extract of L.rupicola.The ethyl acetate extracts from E.aecium S16 and S17 exhibited MIC values ranging from 0.42 to 13.38 mg/mL and from 0.45 to 3.63 mg/mL,respectively.The combinations of sequential solvent fractions derived from four Tibetan veterinary medicinal plants,the ethyl acetate extract of E.faecium,and antibiotics exhibiting high resistance rates demonstrated varying effects.At the MIC,all drug combinations showed a significant biofilm eradication effect compared to their single applications.The ethyl acetate extracts of L.rupicola and T.delavayi,combined with OTC and AMP,demonstrated a stronger inhibitory effect on E.coli E6 biofilm compared to other combinations.Specifically,the ethyl acetate extracts of L.rupicola and T.delavayi inhibited E.coli E6 biofilm by 48.92%and 42.58%in the presence of OTC,and by 48.58%and 47.84%in the presence of AMP,respectively.[Conclusion]The combined application of four selected Tibetan medicinal plants,probiotics,and antibacterial agents may offer a potential solution to address drug resistance and biofilm formation in E.coli isolated from Tibetan pigs and Tibetan chickens.展开更多
[Objective] This study aimed to investigate the treatment efficacy of tradi- tional Chinese veterinary medicine mycoplasma gatlisepticum infection spray against experimental mycoplasma gallisepticum infection. [Method...[Objective] This study aimed to investigate the treatment efficacy of tradi- tional Chinese veterinary medicine mycoplasma gatlisepticum infection spray against experimental mycoplasma gallisepticum infection. [Method] Experimental chickens in- fected with mycoplasma gallisepticum were used as models to investigate the treat- ment efficacy of different doses of traditional Chinese veterinary medicine mycoplas- ma gallisepticum infection spray. [Result] Medication with traditional Chinese veteri- nary medicine mycoplasma gallisepticum infection spray for continuous 5 d showed certain treatment efficacy against mycoplasma gallisepticum infection. The relative weight gain rate of 0.5 and 1.0 g/m3 dose groups was significantly higher than the infection control group （P〈0.01）; the cure rate of mycoplasma gallisepticum infection spray groups was significantly higher than the infection control group （P〈0.01） and showed no significant difference compared with Taimiaoling control group （P〉0.05）; the mortality rate showed no significant difference among various groups （P〉0.05）, indicating that traditional Chinese veterinary medicine mycoplasma gallisepticum in- fection spray has relatively ideal treatment efficacy against mycoplasma gallisepticum infection. [Conclusion] This study provided reference for treatment of chickens infect- ed with mycoplasma gallisepticum.展开更多
With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug del...With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug delivery systems, transdermal patch can maintain stable and effective plasma concentration and therapeutic effect in vivo for a long time after skin dressing delivery, which provides a safe and effective drug-delivery way for the therapy and prevention of some chronic diseases and partial analgesia in a simple and convenient way. Veterinary drug transdermal preparations have been developed both at home and abroad, and satisfactory results have been achieved in the experimental application. Based on the study of veterinary transdermal patches at home and abroad, this paper systematically describes the development and characteristics of transdermal patches, the factors affecting skin permeation and the evaluation this type of preparations in veterinary drugs.展开更多
Albendazole is a benzimidazole derivative with broad spectrum of activity against nematodes and cestodes infections in animals. Bulk of the needed drugs in West African sub-region is imported and adulteration in drug ...Albendazole is a benzimidazole derivative with broad spectrum of activity against nematodes and cestodes infections in animals. Bulk of the needed drugs in West African sub-region is imported and adulteration in drug trade is common. This study was aimed at examining the quality of nine brands of veterinary albendazole boluses commonly used in Nigeria. Bolus weight uniformity, assay, hardness, friability, disintegration time, and dissolution profiles of the brands （250 mg/bolus） were tested according to the official specifications. All the brands tested failed bolus weight uniformity test except brands C and H. The percent albendazole in brands A, B, C and F were within official specification whereas D, E, G, H and I failed. None of the brands passed hardness test. All the products passed friability test except brand E. All the test brands disintegrated within the specified time except B and H. Only brands B, C, E and I passed the dissolution test. Consequently, only brands B and C could be interchanged with the reference. There is need for routine quality control and post market surveillance of veterinary drugs in Nigeria.展开更多
This study explored the removal of five veterinary pharmaceuticals （VPs） （sulfamethoxazole （SMETOX）, trimethoprim （TMP）, ciprofloxacin （CIPRO）, dexamethasone （DEXA） and febantel （FEBA）） from different wa...This study explored the removal of five veterinary pharmaceuticals （VPs） （sulfamethoxazole （SMETOX）, trimethoprim （TMP）, ciprofloxacin （CIPRO）, dexamethasone （DEXA） and febantel （FEBA）） from different water matrices （Milli-Q water, model water, tap water and real pharmaceutical wastewater using four types of nanofiltration （NF） membranes （NF90, NF270, NF and HL） and two reverse osmosis （RO） membranes （LFC-1 and XLE）. All VPs were added to different water matrices at a concentration of 10 mg/L. Rejections of VPs and water flux were measured. The rejection increased with increase of molecular weight. The highest rejections were obtained with RO membranes （LFC-1, XLE） and tight NF （NF90） membrane. In general, the rejection of VPs was higher in model water and tap water than in Milli-Q water, but the water flux was lower. This was mainly explained by ion adsorption inside the membranes pores. Narrower pore size counteracted the effect of presence of low concentration of natural organic matter （NOM） in tap water. The NOM was assumed to enhance the adsorption of VPs onto membrane surface, increased the size exclusion and electrostatic repulsion also appeared during the transport. Investigated water matrices had influence on water flux decline due to their complexity.展开更多
A lab-scale intermittently aerated sequencing batch reactor（IASBR）was applied to treat anaerobically digested swine wastewater（ADSW）to explore the removal characteristics of veterinary antibiotics.The removal rate...A lab-scale intermittently aerated sequencing batch reactor（IASBR）was applied to treat anaerobically digested swine wastewater（ADSW）to explore the removal characteristics of veterinary antibiotics.The removal rates of 11 veterinary antibiotics in the reactor were investigated under different chemical organic demand（COD）volumetric loadings,solid retention times（SRT）and ratios of COD to total nitrogen（TN）or COD/TN.Both sludge sorption and biodegradation were found to be the major contributors to the removal of veterinary antibiotics.Mass balance analysis revealed that greater than 60%of antibiotics in the influent were biodegraded in the IASBR,whereas averagely 24%were adsorbed by sludge under the condition that sludge sorption gradually reached its equilibrium.Results showed that the removal of antibiotics was greatly influenced by chemical oxygen demand（COD）volumetric loadings,which could achieve up to 85.1%±1.4%at 0.17±0.041 kg COD/m-3/day,while dropped to 75.9%±1.3%and 49.3%±12.1%when COD volumetric loading increased to 0.65±0.032 and1.07±0.073 kg COD/m-3/day,respectively.Tetracyclines,the dominant antibiotics in ADSW,were removed by 87.9%in total at the lowest COD loading,of which 30.4%were contributed by sludge sorption and 57.5%by biodegradation,respectively.In contrast,sulfonamides were removed about 96.2%,almost by biodegradation.Long SRT seemed to have little obvious impact on antibiotics removal,while a shorter SRT of 30–40 day could reduce the accumulated amount of antibiotics and the balanced antibiotics sorption capacity of sludge.Influent COD/TN ratio was found not a key impact factor for veterinary antibiotics removal in this work.展开更多
Artemisinin,a constituent of Artemisia annua L.,is a well-known antimalarial drug.Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo.Herbal extracts of A.annua inhibit the growth of cancer cell lin...Artemisinin,a constituent of Artemisia annua L.,is a well-known antimalarial drug.Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo.Herbal extracts of A.annua inhibit the growth of cancer cell lines.Here,we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma.The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A.annua.One cat and one dog with fibrosarcoma survived 40 and 37 months,respectively,without tumor relapse.Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months,respectively.A.annua was well tolerated without noticeable side effects.These four cases indicate that A.annua may be a promising herbal drug for cancer therapy.展开更多
As an important guarantee for the prevention and control of animal diseases,veterinary drugs have important functions in improving animal production performance and product quality and maintaining ecological balance.T...As an important guarantee for the prevention and control of animal diseases,veterinary drugs have important functions in improving animal production performance and product quality and maintaining ecological balance.They are an important guarantee for the healthy development of animal husbandry,food safety and public health.However,the irrational use and abuse of veterinary drugs and feed pharmaceutical additives are widespread,causing harmful substances in animal foods and damage to human health,and threatening the sustainable development of the environment and animal husbandry as well.In order to ensure human health,it is urgent to develop a simple,rapid,high-sensitivity,high-throughput and low-cost veterinary drug residue detection technology.In this paper,the sample pretreatment methods and detection techniques for the analysis of veterinary drug residues in animal foods were reviewed.展开更多
文摘Scopus recently releasedits 2024CiteScore metrics.The 2024 CiteScore for Animal Diseases is 3.6,representing a 50%increase compared to 2023.The journal's ranking has risen significantly:It ranks 38th out of 200 journals in the Veterinary category,marking the 81%and placing it in the Q1 zone.Simultaneously,it ranks 110th out of 509 journals in the Animal Science and Zoology category,placing it at the 78%and also within the Q1 zone.
基金Supported by Project of Sichuan Provincial Department of Science and Technology(2016KZ0007)Science and Technology Project of Sichuan Province(2022JDRC0121)+1 种基金Innovative Research Projects for Postgraduate at Southwest Minzu University(CX2020SZ49)Sichuan Provincial Department of Science and Technology(2023NSFSC0179)。
文摘[Objective]To screen sensitive drugs and their combinations against biofilm formation of Escherichia coli isolated from Tibetan pigs and Tibetan chickens.[Method]Semi-quantitative modified crystal violet staining and the micro broth dilution method were employed to assess the biofilm-forming capacities of 152 E.coli,and their susceptibility to 12 commonly used antibiotics.Meanwhile,the checkerboard testing method was employed to evaluate the combined antibacterial activity of the sequential solvent fractions(methanol,dichloromethane,ethyl acetate,and petroleum ether)from four Tibetan veterinary medicinal plants(Spenceria ramalana Trimen,Thalictrum delawayi Franch.,Gentiana sino-ornata Balf.f.,Lonicera rupicola Hook.f.&Thomson),the ethyl acetate extract of two Enterococcus faecium and antibiotics with high resistance rates[chloramphenicol(CHL),oxytetracycline(OTC),ampicillin(AMP),and sulfamethoxazole(SMZ)]against ten selected multi-drug resistant E.coli(designated E1-E10).Lastly,the biofilm eradication of drug combinations on biofilms of E.coli E6 was examined.[Result]Most of the 152 E.coli exhibited moderate and no biofilm-forming capacities.The resistance rates to CHL,sulfamethazine(SM2),OTC,AMP,and SMZ exceeded 90%.In contrast,the resistance rates to difloxacin(DIF),ciprofloxacin(CIP),amikacin(AMK),ceftiofur(EFT),tobramycin(TOB),and ceftriaxone(CTR)were below 50%.Notably,the strains demonstrated a higher susceptibility to amikacin,with a drug resistance rate of only 19.90%.The MIC values for the E.coli E1-E10 were observed to range from 3.93 to 15.63 mg/mL for the methanol extract of S.ramalana,3.93 to 31.52 mg/mL for the ethyl acetate extract of T.delavayi,7.81 to 15.63 mg/mL for the methanol extract of G.sino-ornata,and 7.81 to 31.52 mg/mL for the ethyl acetate extract of L.rupicola.The ethyl acetate extracts from E.aecium S16 and S17 exhibited MIC values ranging from 0.42 to 13.38 mg/mL and from 0.45 to 3.63 mg/mL,respectively.The combinations of sequential solvent fractions derived from four Tibetan veterinary medicinal plants,the ethyl acetate extract of E.faecium,and antibiotics exhibiting high resistance rates demonstrated varying effects.At the MIC,all drug combinations showed a significant biofilm eradication effect compared to their single applications.The ethyl acetate extracts of L.rupicola and T.delavayi,combined with OTC and AMP,demonstrated a stronger inhibitory effect on E.coli E6 biofilm compared to other combinations.Specifically,the ethyl acetate extracts of L.rupicola and T.delavayi inhibited E.coli E6 biofilm by 48.92%and 42.58%in the presence of OTC,and by 48.58%and 47.84%in the presence of AMP,respectively.[Conclusion]The combined application of four selected Tibetan medicinal plants,probiotics,and antibacterial agents may offer a potential solution to address drug resistance and biofilm formation in E.coli isolated from Tibetan pigs and Tibetan chickens.
基金Supported by Project of Hebei Science and Technology Department(08820412D, 12820421D)Project of Shijiazhuang Municipal Science and Technology Bureau (07150193A)PhD Fund of Hebei Normal University of Science and Technology (2007YB002)~~
文摘[Objective] This study aimed to investigate the treatment efficacy of tradi- tional Chinese veterinary medicine mycoplasma gatlisepticum infection spray against experimental mycoplasma gallisepticum infection. [Method] Experimental chickens in- fected with mycoplasma gallisepticum were used as models to investigate the treat- ment efficacy of different doses of traditional Chinese veterinary medicine mycoplas- ma gallisepticum infection spray. [Result] Medication with traditional Chinese veteri- nary medicine mycoplasma gallisepticum infection spray for continuous 5 d showed certain treatment efficacy against mycoplasma gallisepticum infection. The relative weight gain rate of 0.5 and 1.0 g/m3 dose groups was significantly higher than the infection control group （P〈0.01）; the cure rate of mycoplasma gallisepticum infection spray groups was significantly higher than the infection control group （P〈0.01） and showed no significant difference compared with Taimiaoling control group （P〉0.05）; the mortality rate showed no significant difference among various groups （P〉0.05）, indicating that traditional Chinese veterinary medicine mycoplasma gallisepticum in- fection spray has relatively ideal treatment efficacy against mycoplasma gallisepticum infection. [Conclusion] This study provided reference for treatment of chickens infect- ed with mycoplasma gallisepticum.
基金Supported by the Program for Technology Research and Development and Its Demonstration and Popularization of Beijing Vocational College of Agriculture(XY-YF-15-08)~~
文摘With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug delivery systems, transdermal patch can maintain stable and effective plasma concentration and therapeutic effect in vivo for a long time after skin dressing delivery, which provides a safe and effective drug-delivery way for the therapy and prevention of some chronic diseases and partial analgesia in a simple and convenient way. Veterinary drug transdermal preparations have been developed both at home and abroad, and satisfactory results have been achieved in the experimental application. Based on the study of veterinary transdermal patches at home and abroad, this paper systematically describes the development and characteristics of transdermal patches, the factors affecting skin permeation and the evaluation this type of preparations in veterinary drugs.
文摘Albendazole is a benzimidazole derivative with broad spectrum of activity against nematodes and cestodes infections in animals. Bulk of the needed drugs in West African sub-region is imported and adulteration in drug trade is common. This study was aimed at examining the quality of nine brands of veterinary albendazole boluses commonly used in Nigeria. Bolus weight uniformity, assay, hardness, friability, disintegration time, and dissolution profiles of the brands （250 mg/bolus） were tested according to the official specifications. All the brands tested failed bolus weight uniformity test except brands C and H. The percent albendazole in brands A, B, C and F were within official specification whereas D, E, G, H and I failed. None of the brands passed hardness test. All the products passed friability test except brand E. All the test brands disintegrated within the specified time except B and H. Only brands B, C, E and I passed the dissolution test. Consequently, only brands B and C could be interchanged with the reference. There is need for routine quality control and post market surveillance of veterinary drugs in Nigeria.
基金supported by the Croatian Ministry of Science, Education and Sports Projects: 125-1253008-3009 membrane and adsorption processes for removal of organic compounds in water treatment, 125-1253008-1350 advanced analytical methods for pharmaceuticals determination in the environmentUKF project 05/08: Reduction of environmental risks posed by pharmaceuticals and their degradation products in process wastewaters, through RO/NF membrane treatment (REPHAD)
文摘This study explored the removal of five veterinary pharmaceuticals （VPs） （sulfamethoxazole （SMETOX）, trimethoprim （TMP）, ciprofloxacin （CIPRO）, dexamethasone （DEXA） and febantel （FEBA）） from different water matrices （Milli-Q water, model water, tap water and real pharmaceutical wastewater using four types of nanofiltration （NF） membranes （NF90, NF270, NF and HL） and two reverse osmosis （RO） membranes （LFC-1 and XLE）. All VPs were added to different water matrices at a concentration of 10 mg/L. Rejections of VPs and water flux were measured. The rejection increased with increase of molecular weight. The highest rejections were obtained with RO membranes （LFC-1, XLE） and tight NF （NF90） membrane. In general, the rejection of VPs was higher in model water and tap water than in Milli-Q water, but the water flux was lower. This was mainly explained by ion adsorption inside the membranes pores. Narrower pore size counteracted the effect of presence of low concentration of natural organic matter （NOM） in tap water. The NOM was assumed to enhance the adsorption of VPs onto membrane surface, increased the size exclusion and electrostatic repulsion also appeared during the transport. Investigated water matrices had influence on water flux decline due to their complexity.
文摘A lab-scale intermittently aerated sequencing batch reactor（IASBR）was applied to treat anaerobically digested swine wastewater（ADSW）to explore the removal characteristics of veterinary antibiotics.The removal rates of 11 veterinary antibiotics in the reactor were investigated under different chemical organic demand（COD）volumetric loadings,solid retention times（SRT）and ratios of COD to total nitrogen（TN）or COD/TN.Both sludge sorption and biodegradation were found to be the major contributors to the removal of veterinary antibiotics.Mass balance analysis revealed that greater than 60%of antibiotics in the influent were biodegraded in the IASBR,whereas averagely 24%were adsorbed by sludge under the condition that sludge sorption gradually reached its equilibrium.Results showed that the removal of antibiotics was greatly influenced by chemical oxygen demand（COD）volumetric loadings,which could achieve up to 85.1%±1.4%at 0.17±0.041 kg COD/m-3/day,while dropped to 75.9%±1.3%and 49.3%±12.1%when COD volumetric loading increased to 0.65±0.032 and1.07±0.073 kg COD/m-3/day,respectively.Tetracyclines,the dominant antibiotics in ADSW,were removed by 87.9%in total at the lowest COD loading,of which 30.4%were contributed by sludge sorption and 57.5%by biodegradation,respectively.In contrast,sulfonamides were removed about 96.2%,almost by biodegradation.Long SRT seemed to have little obvious impact on antibiotics removal,while a shorter SRT of 30–40 day could reduce the accumulated amount of antibiotics and the balanced antibiotics sorption capacity of sludge.Influent COD/TN ratio was found not a key impact factor for veterinary antibiotics removal in this work.
文摘Artemisinin,a constituent of Artemisia annua L.,is a well-known antimalarial drug.Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo.Herbal extracts of A.annua inhibit the growth of cancer cell lines.Here,we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma.The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A.annua.One cat and one dog with fibrosarcoma survived 40 and 37 months,respectively,without tumor relapse.Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months,respectively.A.annua was well tolerated without noticeable side effects.These four cases indicate that A.annua may be a promising herbal drug for cancer therapy.
基金Supported by National Beef Industrial Technology System(CARS-38)Basic Science Research Fund(1610322018002)
文摘As an important guarantee for the prevention and control of animal diseases,veterinary drugs have important functions in improving animal production performance and product quality and maintaining ecological balance.They are an important guarantee for the healthy development of animal husbandry,food safety and public health.However,the irrational use and abuse of veterinary drugs and feed pharmaceutical additives are widespread,causing harmful substances in animal foods and damage to human health,and threatening the sustainable development of the environment and animal husbandry as well.In order to ensure human health,it is urgent to develop a simple,rapid,high-sensitivity,high-throughput and low-cost veterinary drug residue detection technology.In this paper,the sample pretreatment methods and detection techniques for the analysis of veterinary drug residues in animal foods were reviewed.
