Introduction The generation of biological wastes such as cow dung and aloe vera waste(AVW)causes a serious ecological pollution.The microbial electrolytic cell coupled with anaerobic digestion(MEC-AD)system can make a...Introduction The generation of biological wastes such as cow dung and aloe vera waste(AVW)causes a serious ecological pollution.The microbial electrolytic cell coupled with anaerobic digestion(MEC-AD)system can make a rational utilization of these biodegradable organic wastes,which is of vital importance for alleviating environmental deterioration and reducing resource waste.Electrode materials and accelerants are the two major factors that affect methane production in the MEC-AD system.They affect microbial attachment and electron transfer in the MEC-AD system.Bio-based carbon materials are carbon materials prepared from biomass as raw materials.They have characteristics such as a rich pore structure,good chemical stability,biocompatibility,and controllable surface properties,which can be used as accelerants and electrodes in the MEC-AD system to optimize its performance.This study was to investigate the influence of biomass-derived carbon as an electrode and accelerant on the performance of the MEC-AD system,and the mechanism for increasing the production of biogas and methane was also analyzed,thus providing a basis for the multifunctional application of biomass-derived carbon in the MEC-AD system.Methods A series of experimental methods were adopted to study the MEC-AD system.Two types of bio-based carbon,i.e.,aloe vera waste derived spherical carbon(AVW-SC)and porous carbon(AVW-PC),were synthesized via hydrothermal carbonization.The raw AVW material was washed with water,dried,ground,and subjected to hydrothermal treatment to obtain AVW-SC.After activating AVW-SC with KOH,it was carbonized in a tube furnace to obtain AVW-PC.In the preparation of the electrodes,bio-based carbon(AVW-SC and AVW-PC)was mixed with 5%polytetrafluoroethylene powder in ethanol and deionized water,and then ground in a ball mill for 4 h to form a slurry.The slurry was evenly sprayed on the Ti mesh,dried and sintered in N2 atmosphere at 360℃to obtain Ti-SC and Ti-PC electrodes.Four groups of experiments were conducted to determine the optimal voltage,compare different carbon electrodes,and explore the optimal coating amount.The MEC-AD reactor adopted 500 mL wide-mouthed glass bottles with a working volume of 400 mL.Each MEC-AD system received a co-substrate mixture of cattle dung and aloe vera waste and inoculum of sewage sludge in a mass ratio of 3:7.Afterward,they were placed at(36±1)℃for 35 d.The biogas was collected by a water displacement method.The materials were analyzed by characterization techniques such as X-ray diffraction(XRD)and scanning electron microscopy(SEM),and electrochemical tests were conducted on different electrodes.The composition,pH,TS,VS,TCOD and nutrient content of biogas were analyzed by standard chemical methods.Microbial community analysis was conducted using high-throughput sequencing technology.The modified Gompertz model was adopted to predict the kinetic parameters,and the coulombic efficiency and methane recovery rate were calculated according to a specific formula.Results and discussion The result shows that AVW-SC is spherical and closely aggregated,while AVW-PC has a three-dimensional network structure,with average pore diameter of 9.77 nm.The electron exchange capacity(EEC)of AVW-PC(i.e.,0.75μmol·e-/g)is higher than that of AVW-SC(i.e.,0.15μmol·e-/g),indicating a better electron exchange capacity.These results indicate that AVW-PC provides more substrate and bacteria accumulation sites,and has better electron-donating and electron-accepting ability,thus improving the digestion efficiency.In the MEC-AD system,using Ti mesh as an electrode,the effect of different voltages(i.e.,0,0.4,0.6,0.8 V and 1.2 V)on the system performance is investigated,obtaining the optimum biogas production and organic matter degradation rate at 0.8 V.AVW-SC and AVW-PC are respectively coated on Ti mesh as electrodes.The results show that the MEC-AD system with AVW-PC coated Ti mesh as the electrode has a better performance.The electrochemical analysis shows that the electrode coated with AVW-PC has a larger specific capacitance and a smaller charge transfer resistance,indicating that AVW-PC can improve the electrochemical properties and electron transfer ability of MEC-AD system.The influence of coating amount(i.e.,0.025,0.05,0.10,0.15,and 0.20 g)of AVW-PC on the MEC-AD system is investigated.At a coating amount of AVW-PC of 0.1 g,the cumulative biogas production and methane content of the Ti_(0.8)-PC_90.1) group both reach the maximum values.Different doses of AVW-PC(i.e.,0.10%,0.15%,0.20%,and 0.25%)are added as accelerants in Ti_(0.8)-PC_90.1).At the addition amount of AVW-PC of 0.20%,the Ti_(0.8)-PC_90.1)/PC0.2 group performs the optimum biogas production(i.e.,633.63 mL/g VS),methane content(i.e.,65.85%),and total nutrient content of biogas residue(i.e.,42.30 g/kg).In Ti_(0.8)-PC_90.1)/PC0.2,Bacteroidales,Pseudomonadales,Oscillospirales,Methanobacteraceae,Methanospirillaceae,Methanosarcinacea and Methanosaetaceae significantly increase.The increase in microbial diversity promotes interspecific hydrogen transfer(IHT),interspecific acetic transfer(IAT),and direct interspecific electron transfer(DIET),thereby enhancing methanogenic efficiency.Conclusions AVW-SC and AVW-PC were utilized as electrodes and accelerants to enhance methane yield in MEC-AD system.The Ti mesh electrode coated with different concentrations of AVW-PC achieved the optimal biogas production at 0.8 V.Specifically,the Ti_(0.8)-PC_90.1) combination could generate the maximum total amount of biogas and methane proportion.The Ti_(0.8)-PC_90.1)/PC0.2 combination exhibited the optimum performance(i.e.,biogas yield of 633.63 mL/g VS,methane content of 65.85%and total nutritional content of 42.30 g/kg).High abundances of Bacteroidales,Pseudomonadales,Oscillospirales,Methanobacteraceae,Methanospirillaceae,Methanosarcinaceae,and Methanosaetaceae appeared in the Ti_(0.8)-PC_90.1)/PC0.2 group,compared to other groups.In addition,an increased microbial diversity led to an enhanced methane production through processes like DIET.This research could highlight the potential significance of AVW-PC as both electrode and accelerator for increasing methane production and provide a perspective for improving MEC-AD performance through multiple applications of biomass-derived carbon.展开更多
BACKGROUND Polycythemia vera(PV)is a myeloproliferative neoplasm characterized by excessive blood cell production,which increases the risk of thrombosis.Ropeginterferon alfa-2b(RI)offers potential advantages over stan...BACKGROUND Polycythemia vera(PV)is a myeloproliferative neoplasm characterized by excessive blood cell production,which increases the risk of thrombosis.Ropeginterferon alfa-2b(RI)offers potential advantages over standard therapy(ST;including phlebotomy,hydroxyurea,and aspirin)by achieving hematologic and molecular responses.However,its comparative efficacy and safety remain understudied.We hypothesized that RI would improve hematologic and molecular outcomes but may differ in safety profiles compared to ST.AIM To evaluate the efficacy and safety of RI vs ST in patients with PV,focusing on hematologic response,molecular response,adverse events(AEs),and thrombotic risk.METHODS This Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant meta-analysis included randomized controlled trials comparing RI to ST in adult PV patients.PubMed,EMBASE,ClinicalTrials.gov,and ScienceDirect were searched from inception to July 2025.Outcomes included complete hematological response(CHR),molecular response,AEs leading to discontinuation,JAK2V617F allele burden,thrombotic events,and phlebotomy frequency.Pooled odds ratios(ORs)and MD with 95%confidence intervals(95%CIs)were calculated using random-effects models.Risk of bias was assessed with Cochrane RoB 2;evidence certainty was evaluated via GRADE.RESULTS Five studies involving 477 RI and 456 ST patients were included.RI significantly improved CHR(OR=2.14,95%CI:1.18-3.88,P=0.002)and molecular response(OR=4.37,95%CI:0.99-19.38,P=0.05),with substantial heterogeneity(I²=76%and I²=93%,respectively).AEs leading to discontinuation were higher with RI(OR=3.89,95%CI:1.90-7.97,P=0.0002;I²=0%).No significant differences were observed in JAK2V617F allele burden(MD=-7.46,95%CI:-21.12 to 6.20,P=0.28;I²=90%)or thrombotic events(OR=0.93,95%CI:0.45-1.90,P=0.83;I²=0%).RI reduced phlebotomy frequency(MD=-1.52,95%CI:-2.37 to-0.67,P=0.0005;I²=0%).Most studies had low to moderate risk of bias;evidence certainty was moderate for CHR and AEs,low for molecular response and thrombotic events,and very low for allele burden.CONCLUSION RI offers superior hematologic and molecular responses compared to ST in PV but is associated with higher discontinuation rates due to AEs.Comparable thrombotic risk and reduced phlebotomy needs highlight its potential,though tolerability requires careful management.The high heterogeneity in certain outcomes and potential for publication bias warrant cautious interpretation of these findings.Further long-term studies are needed to optimize dosing and patient selection.展开更多
Thrombosis is a leading cause of mortality and morbidity in patients suffering from polycythemia vera(PV).Drug pair Salviae Miltiorrhizae Radix et Rhizoma(Danshen,DS)and Notoginseng Radix et Rhizoma(Sanqi,SQ)is common...Thrombosis is a leading cause of mortality and morbidity in patients suffering from polycythemia vera(PV).Drug pair Salviae Miltiorrhizae Radix et Rhizoma(Danshen,DS)and Notoginseng Radix et Rhizoma(Sanqi,SQ)is common traditional Chinese medicine(TCM)used in clinical practice to promote blood circulation and eliminate blood stasis.In this study,network pharmacology and molecular docking were used to analyze the potentially active ingredients and underlying mechanisms of drug pair DS-SQ against thrombosis after PV.These results show that 54 targets are related to both disease and the drug pair.Nineteen core targets,including IL-6 and AKT1,were screened.Luteolin and tanshinone IIa from DS as well as quercetin from SQ might be the major substances in the treatment of thrombosis after PV.KEGG enrichment analysis demonstrated that the lipid and atherosclerosis signaling pathway might play a significant role.These results provide valuable insights and a reference for the use of drug pair DS-SQ in management of thrombosis after PV and lay a foundation for further exploration of pharmacological effects.展开更多
[Objective]The aim was to commercialize micropropagation of pistachio and provide good foundations for varieties improvement. [Method]The seeds and stem-segments were used as explants in the tissue culture of Pistacia...[Objective]The aim was to commercialize micropropagation of pistachio and provide good foundations for varieties improvement. [Method]The seeds and stem-segments were used as explants in the tissue culture of Pistacia vera ＇Kerman＇,tissue culture condition and medium and transplant matrix were researched for micropropagation of pistachio,[Result]Mediums of 1/2DKW and 1/2DKW＋3.00 mg/L of 6-BA ＋0.05 mg/L of NAA were suitable medium for seed germination and axillary bud induction of pistachio; Proliferation coefficient was 3.6 on the medium of 1/2DKW ＋4.00 mg/L of 6-BA ＋ 0.05 mg/L of IBA; Rooting rate was up to 75% on the medium of 1/2DKW ＋ 5.00 mg/L of IBA ＋ 1.00 mg/L of NAA; The suitable transplantation matrix was 3/4 sand ＋ 1/4 vermiculite,and survival rate of plant with root was above 79%. [Conclusion]The pistachio （Kerman） tissue culture technology system was established.展开更多
A multidisciplinary approach-anatomy, histochemistry and phytochemistry-was used to investigate the leaf structure, the content and the storage location of barbaloin in the leaves of Aloe vera L. var. chinensis (Haw.)...A multidisciplinary approach-anatomy, histochemistry and phytochemistry-was used to investigate the leaf structure, the content and the storage location of barbaloin in the leaves of Aloe vera L. var. chinensis (Haw.) Berg. Xeromorphic characteristics including secondary thickened epidermal cell walls, thicker cuticle, ambiguous differentiation of spongy and palisade tissues in the chlorenchyma, and well-developed aquiferous tissue could be seen in the leaves. Several large parenchymatous cells were observed at the phloem pole of the first ring of vascular bundles. The secondary ring of vascular bundles in the leaf base and the stomata, which are surrounded by five cells, have some classification significance in this species. The density of vascular bundles, the content of barbaloin and the intensity of histochemical reaction differed among leaf numbers Ll (annual leaf), L2 (biennial leaf), L3 (triennial leaf) and L4 (quadrennial leaf), and in different parts of the leaf. These three factors were highest in the youngest leaf, Ll, and top parts of all the leaves and lowest in the basal parts and the oldest leaf, L4. The density of vascular bundles had a positive correlation to the content of barbaloin. The histochemical results revealed that the small sheath cells that surrounded the bundles might be the location of barbaloin synthesis and the large parenchymatous cells beneath the sheath might be the storage places of this metabolite.展开更多
[Objective] The paper was to study the occurrence rule of Pistacia vera leaf brown spot and the biological characteristics of its pathogen.[Method] The occurrence rule of P.vera leaf brown spot was investigated in fie...[Objective] The paper was to study the occurrence rule of Pistacia vera leaf brown spot and the biological characteristics of its pathogen.[Method] The occurrence rule of P.vera leaf brown spot was investigated in field.A fungus was isolated and purified from the diseased tissue of P.vera,its cultural trait and morphological characteristics were observed in indoor experiment,and the classification status was identified according to its morphology.The effects of different temperatures on mycelial growth of the pathogen,as well as the effects of different temperatures and humidity on spore germination of the pathogen were also studied.[Result] P.vera leaf brown spot was a fungal disease,which mainly infected the leaves and fruits of P.vera,causing leaf spot and blight.The disease had serious incidence in introduction place of P.vera in China.The fungal disease was identified to be Alternaria alternaria,the appropriate temperature for mycelial growth was 20-25 ℃,the appropriate temperature for spore germination was 25-30 ℃,and the appropriate relative humidity was over 95%.[Conclusion] Late spring and early summer,as well as late summer and early autumn are two peak periods for incidence of the disease,continuous rain in summer is the decisive condition for the infection and outbreak of P.vera leaf brown spot.展开更多
A reserved-phase HPLC method was developed for the determination of barbaloin in Aloe vera L. var. chinensis (Haw.) Berger and Aloe barbadensis Miller, and whether there was a close relationship between the contents o...A reserved-phase HPLC method was developed for the determination of barbaloin in Aloe vera L. var. chinensis (Haw.) Berger and Aloe barbadensis Miller, and whether there was a close relationship between the contents of barbaloin and their environments in which they were growing was decided. A Hypersil ODS column (4.6 mm×200 mm, 5 μm)was used with a mobile phase of methanol-water (40:60, containing 0.1% acetic acid), the flow rate being 1.0 mL·min -1, detection wavelength at 359 nm, and the column temperature being 30℃. The linear range of barbaloin was between 0.0726 and 0.726 μg with a correlation coefficient of 0.9998 and the regression equation being Y=1.9202×10 6X-1801.9. Barbaloin was stable in methanol in 48 h and the instrument precision was 1.2% while the method precision was 4.9%. The contents of barbaloin of 12 samples ranged from 6.160 to 319.1 μg·g -1. The method developed was fast and simple with good reproducibility. There was high correlation between the contents of barbaloin and their growing environments.展开更多
利用自主开发的确定论数值反应堆物理计算程序NECP-X对VERA(virtual environment for reactor application)9#基准题进行全堆芯精细建模计算,显式描述了堆芯格架、管座、端塞、压紧弹簧及气腔等结构,计算得到了整个寿期中的临界硼质量分...利用自主开发的确定论数值反应堆物理计算程序NECP-X对VERA(virtual environment for reactor application)9#基准题进行全堆芯精细建模计算,显式描述了堆芯格架、管座、端塞、压紧弹簧及气腔等结构,计算得到了整个寿期中的临界硼质量分数,给出了3维全堆芯棒功率分布、燃料有效温度分布及慢化剂温度分布,并将计算结果与实测值进行了比较。结果表明,整个寿期中临界硼质量分数的计算值与实测值的偏差小于2.5×10^(-5),计算精度较好;在整个寿期内,随着燃耗的加深,堆芯功率分布逐渐展平,燃料有效温度及慢化剂温度的分布逐渐变得均匀,符合物理规律及预期。展开更多
AIM： To compare the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing. METHODS： Male Spraque-Dawley rats （n=48） were divided into four groups. Group...AIM： To compare the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing. METHODS： Male Spraque-Dawley rats （n=48） were divided into four groups. Group 1 served as control group, group 2 as gastric ulcer group without treatment, groups 3 and 4 as gastric ulcer treatment groups with sucralfate and Aloe vera. The rats from each group were divided into 2 subgroups for study of leukocyte adherence, TNF-α and IL-10 levels and gastric ulcer healing on days 1 and 8 after induction of gastric ulcer by 20% acetic acid. RESULTS： On day 1 after induction of gastric ulcer, the leukocyte adherence in postcapillary venule was significantly （P〈 0.05） increased in the ulcer groups when compared to the control group. The level of TNF-α was elevated and the level of IL-10 was reduced. In the ulcer groups treated with sucralfate and Aloe vera, leukocyte adherence was reduced in postcapillary venule. The level of IL-10 was elevated, but the level of TNF-a had no significant difference. On day 8, the leukocyte adherence in postcapillary venule and the level of TNF-α were still increased and the level of IL-10 was reduced in the ulcer group without treatment. The ulcer treated with sucralfate and Aloe vera had lower leukocyte adherence in postcapillary venule and TNF-α level. The level of IL-10 was still elevated compared to the ulcer group without treatment. Furthermore, histopathological examination of stomach on days 1 and 8 after induction of gastric ulcer showed that gastric tissue was damaged with inflammation. In the ulcer groups treated with sucralfate and Aloe vera on days 1 and 8, gastric inflammation was reduced, epithelial cell proliferation was enhanced and gastric glands became elongated. The ulcer sizes were also reduced compared to the ulcer group without treatment. CONCLUSION： Administration of 20% acetic acid can induce gastric inflammation, increase leukocyte adherence in postcapillary venule and TNF-α level and reduce IL-10 level. Aloe vera treatment can reduce leukocyte adherence and TNF-αlevel, elevate IL-10 level and promote gastric ulcer healing.展开更多
OBJECTIVE: To investigate the use of Aloe vera(A.vera) for the treatment of gastroesophageal reflux disease(GERD) symptoms and compare its effects with those of omeprazole and ranitidine.METHODS: In this pilot, random...OBJECTIVE: To investigate the use of Aloe vera(A.vera) for the treatment of gastroesophageal reflux disease(GERD) symptoms and compare its effects with those of omeprazole and ranitidine.METHODS: In this pilot, randomized controlled trial, 79 subjects were allocated to A. vera syrup(standardized to 5.0 mg polysaccharide per m L of syrup)at a dose of 10 m L/d, omeprazole capsule(20 g/d)or ranitidine tablet(150 mg in a fasted state in the morning and 150 mg 30 min before sleep at night)for a period of 4 weeks. The frequencies of eight main symptoms of GERD(heartburn, food regurgitation, flatulence, belching, dysphagia, nausea,vomiting and acid regurgitation) were assessed at weeks 2 and 4 of the trial.RESULTS: A. vera was safe and well tolerated and reduced the frequencies of all the assessed GERD symptoms, with no adverse events requiring withdrawal.CONCLUSION: A. vera may provide a safe and effective treatment for reducing the symptoms of GERD.展开更多
为了验证反应堆物理软件和方法的计算能力,美国CASL(Consortium for Advanced Simulation of LWRs)项目提出了VERA(Virtual Environment for Reactor Application)堆芯物理基准题。该基准题以Watts Bar初始堆芯为模型,涵盖从二维单栅元...为了验证反应堆物理软件和方法的计算能力,美国CASL(Consortium for Advanced Simulation of LWRs)项目提出了VERA(Virtual Environment for Reactor Application)堆芯物理基准题。该基准题以Watts Bar初始堆芯为模型,涵盖从二维单栅元到三维全堆芯的燃耗及换料的十个基准问题。针对VERA基准题模型,利用COSINE软件包中的反应堆蒙特卡罗分析程序cosRMC进行临界计算,得到了有效增殖因子、组件功率分布、控制棒微积分价值和反应性系数等结果。通过与基准题中提供的KENO结果对比,两种蒙特卡罗程序的计算结果吻合良好。这表明cosRMC程序具有从组件到堆芯的计算能力,其临界计算精度基本与KENO程序相当。展开更多
The unique structural and physical properties of boron carbide, which make it suitable for a wide range of applications,demands the development of low-cost and green synthesis method. In the present work, the commonly...The unique structural and physical properties of boron carbide, which make it suitable for a wide range of applications,demands the development of low-cost and green synthesis method. In the present work, the commonly available leaves of aloe vera are hydrothermally treated to form the carbon precursor for the synthesis of boron carbide. The morphological characterization reveals the porous nature of the precursor turning into a tubular structure upon boron carbide formation.The structural characterization by x-ray diffraction and other spectroscopic techniques such as Fourier transform infrared,Raman, photoluminescence and uv-visible near-infrared spectroscopy confirm the formation of boron carbide. The thermogravimetric analysis of the sample is found to exhibit good thermal stability above 500 °C. When the sample is annealed to 600 °C, boron carbide with phase purity is obtained, which is confirmed through XRD and FTIR analyses. The optical emission properties of the sample are studied through CIE plot and power spectrum. Compared with other natural precursors for boron carbide, the aloe vera is found to give a good yield above 50%.展开更多
文摘Introduction The generation of biological wastes such as cow dung and aloe vera waste(AVW)causes a serious ecological pollution.The microbial electrolytic cell coupled with anaerobic digestion(MEC-AD)system can make a rational utilization of these biodegradable organic wastes,which is of vital importance for alleviating environmental deterioration and reducing resource waste.Electrode materials and accelerants are the two major factors that affect methane production in the MEC-AD system.They affect microbial attachment and electron transfer in the MEC-AD system.Bio-based carbon materials are carbon materials prepared from biomass as raw materials.They have characteristics such as a rich pore structure,good chemical stability,biocompatibility,and controllable surface properties,which can be used as accelerants and electrodes in the MEC-AD system to optimize its performance.This study was to investigate the influence of biomass-derived carbon as an electrode and accelerant on the performance of the MEC-AD system,and the mechanism for increasing the production of biogas and methane was also analyzed,thus providing a basis for the multifunctional application of biomass-derived carbon in the MEC-AD system.Methods A series of experimental methods were adopted to study the MEC-AD system.Two types of bio-based carbon,i.e.,aloe vera waste derived spherical carbon(AVW-SC)and porous carbon(AVW-PC),were synthesized via hydrothermal carbonization.The raw AVW material was washed with water,dried,ground,and subjected to hydrothermal treatment to obtain AVW-SC.After activating AVW-SC with KOH,it was carbonized in a tube furnace to obtain AVW-PC.In the preparation of the electrodes,bio-based carbon(AVW-SC and AVW-PC)was mixed with 5%polytetrafluoroethylene powder in ethanol and deionized water,and then ground in a ball mill for 4 h to form a slurry.The slurry was evenly sprayed on the Ti mesh,dried and sintered in N2 atmosphere at 360℃to obtain Ti-SC and Ti-PC electrodes.Four groups of experiments were conducted to determine the optimal voltage,compare different carbon electrodes,and explore the optimal coating amount.The MEC-AD reactor adopted 500 mL wide-mouthed glass bottles with a working volume of 400 mL.Each MEC-AD system received a co-substrate mixture of cattle dung and aloe vera waste and inoculum of sewage sludge in a mass ratio of 3:7.Afterward,they were placed at(36±1)℃for 35 d.The biogas was collected by a water displacement method.The materials were analyzed by characterization techniques such as X-ray diffraction(XRD)and scanning electron microscopy(SEM),and electrochemical tests were conducted on different electrodes.The composition,pH,TS,VS,TCOD and nutrient content of biogas were analyzed by standard chemical methods.Microbial community analysis was conducted using high-throughput sequencing technology.The modified Gompertz model was adopted to predict the kinetic parameters,and the coulombic efficiency and methane recovery rate were calculated according to a specific formula.Results and discussion The result shows that AVW-SC is spherical and closely aggregated,while AVW-PC has a three-dimensional network structure,with average pore diameter of 9.77 nm.The electron exchange capacity(EEC)of AVW-PC(i.e.,0.75μmol·e-/g)is higher than that of AVW-SC(i.e.,0.15μmol·e-/g),indicating a better electron exchange capacity.These results indicate that AVW-PC provides more substrate and bacteria accumulation sites,and has better electron-donating and electron-accepting ability,thus improving the digestion efficiency.In the MEC-AD system,using Ti mesh as an electrode,the effect of different voltages(i.e.,0,0.4,0.6,0.8 V and 1.2 V)on the system performance is investigated,obtaining the optimum biogas production and organic matter degradation rate at 0.8 V.AVW-SC and AVW-PC are respectively coated on Ti mesh as electrodes.The results show that the MEC-AD system with AVW-PC coated Ti mesh as the electrode has a better performance.The electrochemical analysis shows that the electrode coated with AVW-PC has a larger specific capacitance and a smaller charge transfer resistance,indicating that AVW-PC can improve the electrochemical properties and electron transfer ability of MEC-AD system.The influence of coating amount(i.e.,0.025,0.05,0.10,0.15,and 0.20 g)of AVW-PC on the MEC-AD system is investigated.At a coating amount of AVW-PC of 0.1 g,the cumulative biogas production and methane content of the Ti_(0.8)-PC_90.1) group both reach the maximum values.Different doses of AVW-PC(i.e.,0.10%,0.15%,0.20%,and 0.25%)are added as accelerants in Ti_(0.8)-PC_90.1).At the addition amount of AVW-PC of 0.20%,the Ti_(0.8)-PC_90.1)/PC0.2 group performs the optimum biogas production(i.e.,633.63 mL/g VS),methane content(i.e.,65.85%),and total nutrient content of biogas residue(i.e.,42.30 g/kg).In Ti_(0.8)-PC_90.1)/PC0.2,Bacteroidales,Pseudomonadales,Oscillospirales,Methanobacteraceae,Methanospirillaceae,Methanosarcinacea and Methanosaetaceae significantly increase.The increase in microbial diversity promotes interspecific hydrogen transfer(IHT),interspecific acetic transfer(IAT),and direct interspecific electron transfer(DIET),thereby enhancing methanogenic efficiency.Conclusions AVW-SC and AVW-PC were utilized as electrodes and accelerants to enhance methane yield in MEC-AD system.The Ti mesh electrode coated with different concentrations of AVW-PC achieved the optimal biogas production at 0.8 V.Specifically,the Ti_(0.8)-PC_90.1) combination could generate the maximum total amount of biogas and methane proportion.The Ti_(0.8)-PC_90.1)/PC0.2 combination exhibited the optimum performance(i.e.,biogas yield of 633.63 mL/g VS,methane content of 65.85%and total nutritional content of 42.30 g/kg).High abundances of Bacteroidales,Pseudomonadales,Oscillospirales,Methanobacteraceae,Methanospirillaceae,Methanosarcinaceae,and Methanosaetaceae appeared in the Ti_(0.8)-PC_90.1)/PC0.2 group,compared to other groups.In addition,an increased microbial diversity led to an enhanced methane production through processes like DIET.This research could highlight the potential significance of AVW-PC as both electrode and accelerator for increasing methane production and provide a perspective for improving MEC-AD performance through multiple applications of biomass-derived carbon.
文摘BACKGROUND Polycythemia vera(PV)is a myeloproliferative neoplasm characterized by excessive blood cell production,which increases the risk of thrombosis.Ropeginterferon alfa-2b(RI)offers potential advantages over standard therapy(ST;including phlebotomy,hydroxyurea,and aspirin)by achieving hematologic and molecular responses.However,its comparative efficacy and safety remain understudied.We hypothesized that RI would improve hematologic and molecular outcomes but may differ in safety profiles compared to ST.AIM To evaluate the efficacy and safety of RI vs ST in patients with PV,focusing on hematologic response,molecular response,adverse events(AEs),and thrombotic risk.METHODS This Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant meta-analysis included randomized controlled trials comparing RI to ST in adult PV patients.PubMed,EMBASE,ClinicalTrials.gov,and ScienceDirect were searched from inception to July 2025.Outcomes included complete hematological response(CHR),molecular response,AEs leading to discontinuation,JAK2V617F allele burden,thrombotic events,and phlebotomy frequency.Pooled odds ratios(ORs)and MD with 95%confidence intervals(95%CIs)were calculated using random-effects models.Risk of bias was assessed with Cochrane RoB 2;evidence certainty was evaluated via GRADE.RESULTS Five studies involving 477 RI and 456 ST patients were included.RI significantly improved CHR(OR=2.14,95%CI:1.18-3.88,P=0.002)and molecular response(OR=4.37,95%CI:0.99-19.38,P=0.05),with substantial heterogeneity(I²=76%and I²=93%,respectively).AEs leading to discontinuation were higher with RI(OR=3.89,95%CI:1.90-7.97,P=0.0002;I²=0%).No significant differences were observed in JAK2V617F allele burden(MD=-7.46,95%CI:-21.12 to 6.20,P=0.28;I²=90%)or thrombotic events(OR=0.93,95%CI:0.45-1.90,P=0.83;I²=0%).RI reduced phlebotomy frequency(MD=-1.52,95%CI:-2.37 to-0.67,P=0.0005;I²=0%).Most studies had low to moderate risk of bias;evidence certainty was moderate for CHR and AEs,low for molecular response and thrombotic events,and very low for allele burden.CONCLUSION RI offers superior hematologic and molecular responses compared to ST in PV but is associated with higher discontinuation rates due to AEs.Comparable thrombotic risk and reduced phlebotomy needs highlight its potential,though tolerability requires careful management.The high heterogeneity in certain outcomes and potential for publication bias warrant cautious interpretation of these findings.Further long-term studies are needed to optimize dosing and patient selection.
基金supported by grant from the Project of the National Natural Science Foundation of China(Grant No.82060028)funded by the Yunnan Blood Disease Clinical Medical Center(Grant No.2023YJZX-XY05)+2 种基金the Yunnan Health Commission(L2019003)to TSthe Yunnan Provincial Key Laboratory of Clinical Virology(Grant No.202205AG070005)the Yunnan Provincial Key Laboratory of Innovative Application of Traditional Chinese Medicine.
文摘Thrombosis is a leading cause of mortality and morbidity in patients suffering from polycythemia vera(PV).Drug pair Salviae Miltiorrhizae Radix et Rhizoma(Danshen,DS)and Notoginseng Radix et Rhizoma(Sanqi,SQ)is common traditional Chinese medicine(TCM)used in clinical practice to promote blood circulation and eliminate blood stasis.In this study,network pharmacology and molecular docking were used to analyze the potentially active ingredients and underlying mechanisms of drug pair DS-SQ against thrombosis after PV.These results show that 54 targets are related to both disease and the drug pair.Nineteen core targets,including IL-6 and AKT1,were screened.Luteolin and tanshinone IIa from DS as well as quercetin from SQ might be the major substances in the treatment of thrombosis after PV.KEGG enrichment analysis demonstrated that the lipid and atherosclerosis signaling pathway might play a significant role.These results provide valuable insights and a reference for the use of drug pair DS-SQ in management of thrombosis after PV and lay a foundation for further exploration of pharmacological effects.
基金Supported by Beijing Natural Science Foundation (6072005)Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality(PXM2009-014207-076874)~~
文摘[Objective]The aim was to commercialize micropropagation of pistachio and provide good foundations for varieties improvement. [Method]The seeds and stem-segments were used as explants in the tissue culture of Pistacia vera ＇Kerman＇,tissue culture condition and medium and transplant matrix were researched for micropropagation of pistachio,[Result]Mediums of 1/2DKW and 1/2DKW＋3.00 mg/L of 6-BA ＋0.05 mg/L of NAA were suitable medium for seed germination and axillary bud induction of pistachio; Proliferation coefficient was 3.6 on the medium of 1/2DKW ＋4.00 mg/L of 6-BA ＋ 0.05 mg/L of IBA; Rooting rate was up to 75% on the medium of 1/2DKW ＋ 5.00 mg/L of IBA ＋ 1.00 mg/L of NAA; The suitable transplantation matrix was 3/4 sand ＋ 1/4 vermiculite,and survival rate of plant with root was above 79%. [Conclusion]The pistachio （Kerman） tissue culture technology system was established.
文摘A multidisciplinary approach-anatomy, histochemistry and phytochemistry-was used to investigate the leaf structure, the content and the storage location of barbaloin in the leaves of Aloe vera L. var. chinensis (Haw.) Berg. Xeromorphic characteristics including secondary thickened epidermal cell walls, thicker cuticle, ambiguous differentiation of spongy and palisade tissues in the chlorenchyma, and well-developed aquiferous tissue could be seen in the leaves. Several large parenchymatous cells were observed at the phloem pole of the first ring of vascular bundles. The secondary ring of vascular bundles in the leaf base and the stomata, which are surrounded by five cells, have some classification significance in this species. The density of vascular bundles, the content of barbaloin and the intensity of histochemical reaction differed among leaf numbers Ll (annual leaf), L2 (biennial leaf), L3 (triennial leaf) and L4 (quadrennial leaf), and in different parts of the leaf. These three factors were highest in the youngest leaf, Ll, and top parts of all the leaves and lowest in the basal parts and the oldest leaf, L4. The density of vascular bundles had a positive correlation to the content of barbaloin. The histochemical results revealed that the small sheath cells that surrounded the bundles might be the location of barbaloin synthesis and the large parenchymatous cells beneath the sheath might be the storage places of this metabolite.
基金Supported by "948" Projects of State Forestry Administration "Introduction of Fine Varieties and Cultivation and Management Techniques of Pistacia vera" (96-4-71-02)~~
文摘[Objective] The paper was to study the occurrence rule of Pistacia vera leaf brown spot and the biological characteristics of its pathogen.[Method] The occurrence rule of P.vera leaf brown spot was investigated in field.A fungus was isolated and purified from the diseased tissue of P.vera,its cultural trait and morphological characteristics were observed in indoor experiment,and the classification status was identified according to its morphology.The effects of different temperatures on mycelial growth of the pathogen,as well as the effects of different temperatures and humidity on spore germination of the pathogen were also studied.[Result] P.vera leaf brown spot was a fungal disease,which mainly infected the leaves and fruits of P.vera,causing leaf spot and blight.The disease had serious incidence in introduction place of P.vera in China.The fungal disease was identified to be Alternaria alternaria,the appropriate temperature for mycelial growth was 20-25 ℃,the appropriate temperature for spore germination was 25-30 ℃,and the appropriate relative humidity was over 95%.[Conclusion] Late spring and early summer,as well as late summer and early autumn are two peak periods for incidence of the disease,continuous rain in summer is the decisive condition for the infection and outbreak of P.vera leaf brown spot.
文摘A reserved-phase HPLC method was developed for the determination of barbaloin in Aloe vera L. var. chinensis (Haw.) Berger and Aloe barbadensis Miller, and whether there was a close relationship between the contents of barbaloin and their environments in which they were growing was decided. A Hypersil ODS column (4.6 mm×200 mm, 5 μm)was used with a mobile phase of methanol-water (40:60, containing 0.1% acetic acid), the flow rate being 1.0 mL·min -1, detection wavelength at 359 nm, and the column temperature being 30℃. The linear range of barbaloin was between 0.0726 and 0.726 μg with a correlation coefficient of 0.9998 and the regression equation being Y=1.9202×10 6X-1801.9. Barbaloin was stable in methanol in 48 h and the instrument precision was 1.2% while the method precision was 4.9%. The contents of barbaloin of 12 samples ranged from 6.160 to 319.1 μg·g -1. The method developed was fast and simple with good reproducibility. There was high correlation between the contents of barbaloin and their growing environments.
文摘利用自主开发的确定论数值反应堆物理计算程序NECP-X对VERA(virtual environment for reactor application)9#基准题进行全堆芯精细建模计算,显式描述了堆芯格架、管座、端塞、压紧弹簧及气腔等结构,计算得到了整个寿期中的临界硼质量分数,给出了3维全堆芯棒功率分布、燃料有效温度分布及慢化剂温度分布,并将计算结果与实测值进行了比较。结果表明,整个寿期中临界硼质量分数的计算值与实测值的偏差小于2.5×10^(-5),计算精度较好;在整个寿期内,随着燃耗的加深,堆芯功率分布逐渐展平,燃料有效温度及慢化剂温度的分布逐渐变得均匀,符合物理规律及预期。
基金Supported by Rajadapiseksompoj Research Fund, Faculty of Medicine and Research Fund by Graduate School, Chulalongkom University
文摘AIM： To compare the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing. METHODS： Male Spraque-Dawley rats （n=48） were divided into four groups. Group 1 served as control group, group 2 as gastric ulcer group without treatment, groups 3 and 4 as gastric ulcer treatment groups with sucralfate and Aloe vera. The rats from each group were divided into 2 subgroups for study of leukocyte adherence, TNF-α and IL-10 levels and gastric ulcer healing on days 1 and 8 after induction of gastric ulcer by 20% acetic acid. RESULTS： On day 1 after induction of gastric ulcer, the leukocyte adherence in postcapillary venule was significantly （P〈 0.05） increased in the ulcer groups when compared to the control group. The level of TNF-α was elevated and the level of IL-10 was reduced. In the ulcer groups treated with sucralfate and Aloe vera, leukocyte adherence was reduced in postcapillary venule. The level of IL-10 was elevated, but the level of TNF-a had no significant difference. On day 8, the leukocyte adherence in postcapillary venule and the level of TNF-α were still increased and the level of IL-10 was reduced in the ulcer group without treatment. The ulcer treated with sucralfate and Aloe vera had lower leukocyte adherence in postcapillary venule and TNF-α level. The level of IL-10 was still elevated compared to the ulcer group without treatment. Furthermore, histopathological examination of stomach on days 1 and 8 after induction of gastric ulcer showed that gastric tissue was damaged with inflammation. In the ulcer groups treated with sucralfate and Aloe vera on days 1 and 8, gastric inflammation was reduced, epithelial cell proliferation was enhanced and gastric glands became elongated. The ulcer sizes were also reduced compared to the ulcer group without treatment. CONCLUSION： Administration of 20% acetic acid can induce gastric inflammation, increase leukocyte adherence in postcapillary venule and TNF-α level and reduce IL-10 level. Aloe vera treatment can reduce leukocyte adherence and TNF-αlevel, elevate IL-10 level and promote gastric ulcer healing.
基金Supported by the Clinical Trial Research CenterTehranIran
文摘OBJECTIVE: To investigate the use of Aloe vera(A.vera) for the treatment of gastroesophageal reflux disease(GERD) symptoms and compare its effects with those of omeprazole and ranitidine.METHODS: In this pilot, randomized controlled trial, 79 subjects were allocated to A. vera syrup(standardized to 5.0 mg polysaccharide per m L of syrup)at a dose of 10 m L/d, omeprazole capsule(20 g/d)or ranitidine tablet(150 mg in a fasted state in the morning and 150 mg 30 min before sleep at night)for a period of 4 weeks. The frequencies of eight main symptoms of GERD(heartburn, food regurgitation, flatulence, belching, dysphagia, nausea,vomiting and acid regurgitation) were assessed at weeks 2 and 4 of the trial.RESULTS: A. vera was safe and well tolerated and reduced the frequencies of all the assessed GERD symptoms, with no adverse events requiring withdrawal.CONCLUSION: A. vera may provide a safe and effective treatment for reducing the symptoms of GERD.
文摘为了验证反应堆物理软件和方法的计算能力,美国CASL(Consortium for Advanced Simulation of LWRs)项目提出了VERA(Virtual Environment for Reactor Application)堆芯物理基准题。该基准题以Watts Bar初始堆芯为模型,涵盖从二维单栅元到三维全堆芯的燃耗及换料的十个基准问题。针对VERA基准题模型,利用COSINE软件包中的反应堆蒙特卡罗分析程序cosRMC进行临界计算,得到了有效增殖因子、组件功率分布、控制棒微积分价值和反应性系数等结果。通过与基准题中提供的KENO结果对比,两种蒙特卡罗程序的计算结果吻合良好。这表明cosRMC程序具有从组件到堆芯的计算能力,其临界计算精度基本与KENO程序相当。
基金support from UGC-SAP (DRS, Phase Ⅲ) with Sanction order No. F.510/3/DRS-Ⅲ/2015(SAPI)UGC-MRP with F. No. 43-539/2014 (SR)FD Diary No.3668
文摘The unique structural and physical properties of boron carbide, which make it suitable for a wide range of applications,demands the development of low-cost and green synthesis method. In the present work, the commonly available leaves of aloe vera are hydrothermally treated to form the carbon precursor for the synthesis of boron carbide. The morphological characterization reveals the porous nature of the precursor turning into a tubular structure upon boron carbide formation.The structural characterization by x-ray diffraction and other spectroscopic techniques such as Fourier transform infrared,Raman, photoluminescence and uv-visible near-infrared spectroscopy confirm the formation of boron carbide. The thermogravimetric analysis of the sample is found to exhibit good thermal stability above 500 °C. When the sample is annealed to 600 °C, boron carbide with phase purity is obtained, which is confirmed through XRD and FTIR analyses. The optical emission properties of the sample are studied through CIE plot and power spectrum. Compared with other natural precursors for boron carbide, the aloe vera is found to give a good yield above 50%.
