The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic fu...The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic functions in the unit ball by radial derivative.Then we extend the Sharma's results.展开更多
This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based...This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based on the internal model principle,a distributed dynamic output feedback control law is proposed to achieve both robust output regulation of the closed-loop system and plant input sharing among the actuators.A practical example of five motors cooperatively driving an uncertain shaft under an external load torque is presented to show the effectiveness of the proposed control law.展开更多
To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on int...To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on integer linear programming(ILP)with flow balance constraints,ensuring the fair and efficient distribution of sub-areas among USVs and maintaining strong connectivity of assigned regions.In the established gridmap,a search-based path planning algorithm is performed on the sub-areas according to the allocation scheme.It uses the greedy algorithm and the A*algorithm to achieve complete coverage of the barrier-free area and obtain an efficient trajectory of each USV.The greedy algorithm enables fast local traversal of unvisited grids,while the A*algorithm ensures navigation to escape from deadlock areas and maintains global path continuity.The comparison of task allocation results proves that the task allocation algorithm based on ILP improves the mapping efficiency and task distribution fairness.The proposed allocation method and result analysis provide a certain reference for the practical application ofMulti-USV to perform survey tasks collaboratively.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framew...Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framework that jointly designs distributed observers and local controllers to ensure robust formation control in the presence of external disturbances and sensor malfunctions.Treating the spacecraft formation as a single interconnected system,each spacecraft constructs a distributed observer that estimates the overall system state by incorporating both its own measurements and the predicted control information shared among the spacecraft.Based on the observer estimates,a local control law is synthesized to maintain the desired formation.Rigorous theoretical analysis and numerical simulations demonstrate that the proposed integrated approach effectively guarantees formation stability and resilience against sensor failures and disturbances.展开更多
This paper is dedicated to fixed-time passivity and synchronization for multi-weighted spatiotemporal directed networks.First,to achieve fixed-time passivity,a type of decentralized power-law controller is developed,i...This paper is dedicated to fixed-time passivity and synchronization for multi-weighted spatiotemporal directed networks.First,to achieve fixed-time passivity,a type of decentralized power-law controller is developed,in which only one parameter needs to be adjusted in the power-law terms;this greatly decreases the inconvenience of parameter adjustment.Second,several fixed-time passivity criteria with LMI forms are derived by using a Gauss divergence theorem to deal with the spatial diffusion of nodes and by applying the Hölder’s inequality to dispose rigorously the power-law term greater than one in the designed control scheme;this improves the previous theoretical analysis.Additionally,the fixed-time synchronization of spatiotemporal directed networks with multi-weights is addressed as a direct result of fixed-time strict passivity.Finally,a numerical example is presented in order to show the validity of the theoretical analysis.展开更多
Driven by the trend of device miniaturization and high-density integration,the interaction between adjacent electrodes has become a critical factor affecting the interfacial reliability of thermoelectric(TE)structures...Driven by the trend of device miniaturization and high-density integration,the interaction between adjacent electrodes has become a critical factor affecting the interfacial reliability of thermoelectric(TE)structures.This study investigates the influence of adjoining electrode interactions on the interfacial response of a multi-electrode/TE substrate structure,including interfacial stresses and stress intensity factors at the electrode ends.To solve the corresponding boundary-value problem,the Fourier transforms are adopted to derive a governing integro-differential equation for the interfacial shear stress in multi-electrode systems,incorporating the TE effects as generalized forces on the right-hand side.The results show that both the interfacial tension and transverse stress in the electrodes are significantly affected by the presence of adjacent electrodes.The interaction between neighboring electrodes diminishes as their spacing increases or when an adhesive interlayer is introduced.Furthermore,the softer and thinner electrodes,the softer and thicker adhesive interlayer,and the smaller TE loads are found to be beneficial for improving the interfacial performance.These findings may contribute to the accurate measurement in surface sensors and layout design of multi-point health monitoring systems for TE structures.展开更多
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte...BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.展开更多
AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patie...AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients.展开更多
Multiple sclerosis is a severe autoimmune disorder that is mainly mediated by pathogenic cluster of CD4^(+)T cell subsets.Despite advancements in the management of multiple sclerosis,there is a critical need for more ...Multiple sclerosis is a severe autoimmune disorder that is mainly mediated by pathogenic cluster of CD4^(+)T cell subsets.Despite advancements in the management of multiple sclerosis,there is a critical need for more effective and safer treatments.In the present study,we administered Lycium barbarum glycopeptide to a mouse model of experimental autoimmune encephalomyelitis-an animal model of multiple sclerosis-and evaluated its effects on pathogenic CD4^(+)T cell activation both in vivo and in vitro.Lycium barbarum glycopeptide significantly mitigated the clinical severity of experimental autoimmune encephalomyelitis,as demonstrated by reduced demyelination and neuroinflammation.Moreover,Lycium barbarum glycopeptide treatment decreased the infiltration of peripheral leukocytes into the central nervous system and suppressed pro-inflammatory cytokine expression.Lycium barbarum glycopeptide also modulated pathogenic CD4^(+)T cell activation by inhibiting T helper 1/T helper 17 cell differentiation while promoting regulatory T cell expansion.Notably,no side effects were observed,suggesting the long-term safety and tolerability of Lycium barbarum glycopeptide.Furthermore,RNA sequencing data indicated that Lycium barbarum glycopeptide inhibits activator protein-1,an essential regulator of T cell activation and differentiation.This finding was supported by the reversal of T helper/T helper 17 cell response suppression upon AP-1 blockade.Collectively,these results highlight the potential of Lycium barbarum glycopeptide as an innovative therapeutic agent for CD4^(+)T cell-associated autoimmune or inflammatory diseases,such as multiple sclerosis.展开更多
Objective The purpose of this experiment was to investigate the effects of exogenous hormone factors on subculture multiplication and root induction of tis-suecultured seedlings in mulberry. [Method] The aseptic seedl...Objective The purpose of this experiment was to investigate the effects of exogenous hormone factors on subculture multiplication and root induction of tis-suecultured seedlings in mulberry. [Method] The aseptic seedlings of Guisangyou 12 were used as the materials and the comparative experiment on subculture multi-plication and root induction used different kinds,concentrations and combinations of exogenous hormones. [Result] The hormone combination of 0.1 mg/L IBA＋1.5 mg/L 6-BA＋0.03 mg/L TDZ showed the best effects to bud multiplication, and the multiple of bud multiplication was 5.28. The effects of NAA was better than IBA and IAA on root induction. The hormone combination of 2.0 mg/L NAA＋1.0 mg/L PP333 was most suitable to the root induction, in which the rooting rate arrived to 100%, the root number was 7.01 and the root length was 1.38 cm on average. [Conclusion] The results wil provide some technical reference for large-scale propagation of mul-berry seedlings in vitro.展开更多
[Objective] This study aimed to shorten the multiplication culture and root- ing culture periods of Rh. chrysanthum Pall. [Method] The Rh. chrysanthum Pall tis- sue culture plantlets collected from Changbai Mountain w...[Objective] This study aimed to shorten the multiplication culture and root- ing culture periods of Rh. chrysanthum Pall. [Method] The Rh. chrysanthum Pall tis- sue culture plantlets collected from Changbai Mountain were used as material, and the effects of different hormone combinations and coconut milk on the proliferation and differentiation of Rh. chrysanthum Pall tissue culture plantlets were investigated. In addition, the rooting medium and transplanting matrix for Rh. chrysanthum Pall tissue culture plantlets were explored. [Result] The medium composed of modified MS, iBA （3 mg/L） and ZT （1.5 mg/L） was the optimum medium for subculture mul- tiplication of Rh. chrysanthum Pall tissue culture plantlets. The multiplication multiple and average plant height were significantly improved by adding coconut milk into the medium （150 mg/L）. [Conclusion] For Rh. chrysanthum Pall tissue culture plantlets, the optimum rooting culture medium was composed of modified MS （1/4） and IBA （5.0 mg/L）, and the tissue culture plantlets began to root 8 d after the inoculation. The root induction treatment was carried out after a 15-d sand culture, and the suitable matrix was composed of tufty soil, humus soil and perlite （2：1：1） with a survival rate of 95.66%.展开更多
A preliminary feasibility study was set up for the HNBM standard system. By introducing the set theory and basic methods of the solid geometry and adopting the Verman three-dimensional structure ideology innovatively,...A preliminary feasibility study was set up for the HNBM standard system. By introducing the set theory and basic methods of the solid geometry and adopting the Verman three-dimensional structure ideology innovatively, the standards system of Hainan National Breeding and Multiplication (HNBM) was studied with the four-dimensional structure and integration by combining with the time dimension. The four-dimensional structure standards system will be useful for guiding the construction of the HNBM standards system, carrying on the division of labor and realizing the dynamic development of the standards system. The standards set of HNBM helps to computer programming and information management.展开更多
[Objective] The aims was to explore PTGMS line purification and multipli- cation technology. [Method] Three commercial PTGMS lines, Annong 810S, P88S and C815S, were used in this study. In the first year, two sterile ...[Objective] The aims was to explore PTGMS line purification and multipli- cation technology. [Method] Three commercial PTGMS lines, Annong 810S, P88S and C815S, were used in this study. In the first year, two sterile line populations with same genetic background were multiplied by dividing seedling; meanwhile, se- lection and multiplication of the core individuals were conducted; within the year, the core seeds harvested were multiplied under the isolated condition in Hainan, and at the same time, superior individuals were selected and used as the seeds for two populations with same genetic background in the next year. In the second year, seeds harvested in Hainan were planted in Changsha, while the core individuals were selected and multiplied; the core seeds harvested were continued to multiply in Hainan. The above procedures were repeated in the following years. [Result] The test results showed that in two years the proportion of core individuals in the popu- lation of Annong 810S, P88S and C815S increased from 40.3%, 0.7% and 0.3% in the first year to 71.67%, 66.00% and 68.67% in the second year respectively. [Conclusion] This suggested that this method of purification and multiplication of the PTGMS lines for consecutive years can effectively control the drift of the critical sterility inducing temperature, and at the same time, core seeds with high purity and controlled inducing temperature can be harvested.展开更多
To resist the side chaimel attacks of elliptic curve cryptography, a new fast and secure point multiplication algorithm is proposed. The algorithm is based on a particular kind of addition chains involving only additi...To resist the side chaimel attacks of elliptic curve cryptography, a new fast and secure point multiplication algorithm is proposed. The algorithm is based on a particular kind of addition chains involving only additions, providing a natural protection against side channel attacks. Moreover, the new addition formulae that take into account the specific structure of those chains making point multiplication very efficient are proposed. The point multiplication algorithm only needs 1 719 multiplications for the SAC260 of 160-bit integers. For chains of length from 280 to 260, the proposed method outperforms all the previous methods with a gain of 26% to 31% over double-and add, 16% to22% over NAF, 7% to 13% over4-NAF and 1% to 8% over the present best algorithm--double-base chain.展开更多
Based on winter nursery and shuttle breeding, Hainan National Breeding and Multiplication （HNBM）, with off-season breeding and seed production as the essence, has become a national strategic resource. The way of HNB...Based on winter nursery and shuttle breeding, Hainan National Breeding and Multiplication （HNBM）, with off-season breeding and seed production as the essence, has become a national strategic resource. The way of HNBM rising to the national strategy was analyzed through the aspects of technology features, historical characteristics, irreplaceability, function and value hierarchy, and the key problems. As the major achievement of the practice of scientific research and historical selec- tion, HNBM played an irreplaceable role in the climatic conditions, scientific breed- ing, and seed production in disaster relief, protecting the safety of the seed industry and Iocational advantages. Based on the analysis on the functions, values and ex- isted problems of HNBM, the function and value hierarchical structure of HNBM was established through introducing concepts of value engineering, industrial clusters and regional economy. But to fully achieve the industrial clustering development and functional values of HNBM, it needed to solve the key problems existed in top-level planning, experimental bases, system design, hardware construction and ecological security. Some suggestions were put forward in this paper, including setting up key scientific research protection zones, improving the regulations and policies safeguard mechanism and management system of HNBM, drawing up and carrying out the base development planning of HNBM, and striving for financial support from national policies.展开更多
This article is devoted to characterizing the boundedness and compactness of multiplication operators from Hardy spaces to weighted Bergman spaces in the unit ball of ■.
With the rhizomes obtained from the germination of Cymbidium sinense ~ Cymbidium goeringii seeds as a material, the effects of different basic media and different plant growth regulators on the multiplication and diff...With the rhizomes obtained from the germination of Cymbidium sinense ~ Cymbidium goeringii seeds as a material, the effects of different basic media and different plant growth regulators on the multiplication and differentiation of rhizomes and rooting and transplanting of seedlings were investigated. The results showed that the basal medium more suitable for the multiplication and differentiation of rhizomes was 1/2MS; the medium more suitable for the multiplication and differentiation of rhizomes of the hybrid orchid was 1/2MS ＋ 6 - BA 2.0 mg/L ＋ KT 0.5 mg/L ＋ NAA 0.05 mg/L; the medium more suitable for the rooting of the hybrid orchid was 1/2MS ＋ IBA 0.5 mg/L; and after training of seedlings, transplanting was performed onto moss, and after 25 d, the survival rate was 95.6%.展开更多
We developed a shoot multiplication protocol for Syringa reticulata Blume vat. mandshurica Hara from in vitro cultured seedlings that derived from in vitro germinated seeds. The shoots could be induced on Murashige an...We developed a shoot multiplication protocol for Syringa reticulata Blume vat. mandshurica Hara from in vitro cultured seedlings that derived from in vitro germinated seeds. The shoots could be induced on Murashige and Skoog （MS） medium with proper plant growth regulator combinations of 6-benzylaminopurine （BA） and indole-3-butyric acid （IBA）. The better medium for shoot multiplication and growth was MS ＋ 5 mg L-1 BA ＋ 0.5 mg L-1 IBA ＋ 20 g L-1 sucrose ＋ 7 g L-1 agar, and the corresponding shoot induction rate was 75 %. The plantlets grew well after rooting on I/2MS medium （macro-elements of MS medium are at half-strength） sup- plemented with 1 mg L-1 IBA, and the survival percentage was 〉80 % at 16 weeks after transplanting.展开更多
基金Supported by Natural Science Foundation of Guangdong Province in China(2018KTSCX161)。
文摘The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic functions in the unit ball by radial derivative.Then we extend the Sharma's results.
基金Supported by the Shenzhen Key Laboratory of Control Theory and Intelligent Systems (ZDSYS20220330161800001)the National Natural Science Foundation of China (62303207)the Guangdong Basic and Applied Basic Research Foundation (2024A1515010725)。
文摘This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based on the internal model principle,a distributed dynamic output feedback control law is proposed to achieve both robust output regulation of the closed-loop system and plant input sharing among the actuators.A practical example of five motors cooperatively driving an uncertain shaft under an external load torque is presented to show the effectiveness of the proposed control law.
基金supported in part by the International Science and Technology Project of Guangzhou Development District under Grant 2023GH08the Science and Technology Development Fund,MSAR,under Grants 0029/2022/AGJ and 0029/2023/RIA1the Program of Guangdong under Grant 2023A0505020003.
文摘To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on integer linear programming(ILP)with flow balance constraints,ensuring the fair and efficient distribution of sub-areas among USVs and maintaining strong connectivity of assigned regions.In the established gridmap,a search-based path planning algorithm is performed on the sub-areas according to the allocation scheme.It uses the greedy algorithm and the A*algorithm to achieve complete coverage of the barrier-free area and obtain an efficient trajectory of each USV.The greedy algorithm enables fast local traversal of unvisited grids,while the A*algorithm ensures navigation to escape from deadlock areas and maintains global path continuity.The comparison of task allocation results proves that the task allocation algorithm based on ILP improves the mapping efficiency and task distribution fairness.The proposed allocation method and result analysis provide a certain reference for the practical application ofMulti-USV to perform survey tasks collaboratively.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
基金supported by the National Natural Science Foundation of China(62088101,62522307,62273045,U2341213)Beijing Nova Program(20230484481)。
文摘Formation control of multiple spacecraft has attracted extensive research attention.However,achieving reliable performance under sensor failures remains a significant challenge.This paper develops an integrated framework that jointly designs distributed observers and local controllers to ensure robust formation control in the presence of external disturbances and sensor malfunctions.Treating the spacecraft formation as a single interconnected system,each spacecraft constructs a distributed observer that estimates the overall system state by incorporating both its own measurements and the predicted control information shared among the spacecraft.Based on the observer estimates,a local control law is synthesized to maintain the desired formation.Rigorous theoretical analysis and numerical simulations demonstrate that the proposed integrated approach effectively guarantees formation stability and resilience against sensor failures and disturbances.
基金supported by the National Natural Science Foundation of China(62373317)the Tianshan Talent Training Program(2022TSYCCX0013)+3 种基金the Key Project of Natural Science Foundation of Xinjiang(2021D01D10)the Basic Research Foundation for Universities of Xinjiang(XJEDU2023P023)the Xinjiang Key Laboratory of Applied Mathematics(XJDX1401)the Intelligent Control and Optimization Research Platform in Xinjiang University.
文摘This paper is dedicated to fixed-time passivity and synchronization for multi-weighted spatiotemporal directed networks.First,to achieve fixed-time passivity,a type of decentralized power-law controller is developed,in which only one parameter needs to be adjusted in the power-law terms;this greatly decreases the inconvenience of parameter adjustment.Second,several fixed-time passivity criteria with LMI forms are derived by using a Gauss divergence theorem to deal with the spatial diffusion of nodes and by applying the Hölder’s inequality to dispose rigorously the power-law term greater than one in the designed control scheme;this improves the previous theoretical analysis.Additionally,the fixed-time synchronization of spatiotemporal directed networks with multi-weights is addressed as a direct result of fixed-time strict passivity.Finally,a numerical example is presented in order to show the validity of the theoretical analysis.
基金Project supported by the National Natural Science Foundation of China(Nos.12502117,12272269,11972257)the Natural Science Foundation of Ningxia of China(No.2024AAC03018)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Shanghai Gaofeng Project for University Academic Program Development。
文摘Driven by the trend of device miniaturization and high-density integration,the interaction between adjacent electrodes has become a critical factor affecting the interfacial reliability of thermoelectric(TE)structures.This study investigates the influence of adjoining electrode interactions on the interfacial response of a multi-electrode/TE substrate structure,including interfacial stresses and stress intensity factors at the electrode ends.To solve the corresponding boundary-value problem,the Fourier transforms are adopted to derive a governing integro-differential equation for the interfacial shear stress in multi-electrode systems,incorporating the TE effects as generalized forces on the right-hand side.The results show that both the interfacial tension and transverse stress in the electrodes are significantly affected by the presence of adjacent electrodes.The interaction between neighboring electrodes diminishes as their spacing increases or when an adhesive interlayer is introduced.Furthermore,the softer and thinner electrodes,the softer and thicker adhesive interlayer,and the smaller TE loads are found to be beneficial for improving the interfacial performance.These findings may contribute to the accurate measurement in surface sensors and layout design of multi-point health monitoring systems for TE structures.
基金Supported by Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau),No.2023MSXM060.
文摘BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.
文摘AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients.
基金supported by the National Natural Science Foundational of China,Nos.U24A20692(to CJZ),82371355(to CJZ),and 82101414(to MH)National NaturalScience Foundational of China for Excellent Young Scholars,No.82022019(to CJZ)+5 种基金Sichuan Special Fund for Distinguished Young Scholars,No.24NSFJQ0052(to CJZ)The Innovationand Entrepreneurial Team of Sichuan Tianfu Emei Program,No.CZ2024018(to CJZ)Funding for Distinguished Young Scholars of Sichuan Provincial People’sHospital,No.30420230005Funding for Distinguished Young Scholars of University of Electronic Science and Technology of China,No.A1098531023601381(toCJZ)Sichuan Science and Technology Support Project,No.2023YFS0212(to BH)Project of Sichuan Provincial Health Commission,No.19PJ265(to LD).
文摘Multiple sclerosis is a severe autoimmune disorder that is mainly mediated by pathogenic cluster of CD4^(+)T cell subsets.Despite advancements in the management of multiple sclerosis,there is a critical need for more effective and safer treatments.In the present study,we administered Lycium barbarum glycopeptide to a mouse model of experimental autoimmune encephalomyelitis-an animal model of multiple sclerosis-and evaluated its effects on pathogenic CD4^(+)T cell activation both in vivo and in vitro.Lycium barbarum glycopeptide significantly mitigated the clinical severity of experimental autoimmune encephalomyelitis,as demonstrated by reduced demyelination and neuroinflammation.Moreover,Lycium barbarum glycopeptide treatment decreased the infiltration of peripheral leukocytes into the central nervous system and suppressed pro-inflammatory cytokine expression.Lycium barbarum glycopeptide also modulated pathogenic CD4^(+)T cell activation by inhibiting T helper 1/T helper 17 cell differentiation while promoting regulatory T cell expansion.Notably,no side effects were observed,suggesting the long-term safety and tolerability of Lycium barbarum glycopeptide.Furthermore,RNA sequencing data indicated that Lycium barbarum glycopeptide inhibits activator protein-1,an essential regulator of T cell activation and differentiation.This finding was supported by the reversal of T helper/T helper 17 cell response suppression upon AP-1 blockade.Collectively,these results highlight the potential of Lycium barbarum glycopeptide as an innovative therapeutic agent for CD4^(+)T cell-associated autoimmune or inflammatory diseases,such as multiple sclerosis.
基金Supported by Post-graduate Innovation Program of Guangxi(YCSZ2013007)~~
文摘Objective The purpose of this experiment was to investigate the effects of exogenous hormone factors on subculture multiplication and root induction of tis-suecultured seedlings in mulberry. [Method] The aseptic seedlings of Guisangyou 12 were used as the materials and the comparative experiment on subculture multi-plication and root induction used different kinds,concentrations and combinations of exogenous hormones. [Result] The hormone combination of 0.1 mg/L IBA＋1.5 mg/L 6-BA＋0.03 mg/L TDZ showed the best effects to bud multiplication, and the multiple of bud multiplication was 5.28. The effects of NAA was better than IBA and IAA on root induction. The hormone combination of 2.0 mg/L NAA＋1.0 mg/L PP333 was most suitable to the root induction, in which the rooting rate arrived to 100%, the root number was 7.01 and the root length was 1.38 cm on average. [Conclusion] The results wil provide some technical reference for large-scale propagation of mul-berry seedlings in vitro.
基金Supported by Students'Innovation and Entrepreneurship Training Program of Yanbian University in 2015(ydbksky2015252)~~
文摘[Objective] This study aimed to shorten the multiplication culture and root- ing culture periods of Rh. chrysanthum Pall. [Method] The Rh. chrysanthum Pall tis- sue culture plantlets collected from Changbai Mountain were used as material, and the effects of different hormone combinations and coconut milk on the proliferation and differentiation of Rh. chrysanthum Pall tissue culture plantlets were investigated. In addition, the rooting medium and transplanting matrix for Rh. chrysanthum Pall tissue culture plantlets were explored. [Result] The medium composed of modified MS, iBA （3 mg/L） and ZT （1.5 mg/L） was the optimum medium for subculture mul- tiplication of Rh. chrysanthum Pall tissue culture plantlets. The multiplication multiple and average plant height were significantly improved by adding coconut milk into the medium （150 mg/L）. [Conclusion] For Rh. chrysanthum Pall tissue culture plantlets, the optimum rooting culture medium was composed of modified MS （1/4） and IBA （5.0 mg/L）, and the tissue culture plantlets began to root 8 d after the inoculation. The root induction treatment was carried out after a 15-d sand culture, and the suitable matrix was composed of tufty soil, humus soil and perlite （2：1：1） with a survival rate of 95.66%.
文摘A preliminary feasibility study was set up for the HNBM standard system. By introducing the set theory and basic methods of the solid geometry and adopting the Verman three-dimensional structure ideology innovatively, the standards system of Hainan National Breeding and Multiplication (HNBM) was studied with the four-dimensional structure and integration by combining with the time dimension. The four-dimensional structure standards system will be useful for guiding the construction of the HNBM standards system, carrying on the division of labor and realizing the dynamic development of the standards system. The standards set of HNBM helps to computer programming and information management.
基金Supported by National High Technology Research and Development Program of China(2010AA101305,2011AA10A101)National Science and Technology Supporting Project(2012BAD48G01)~~
文摘[Objective] The aims was to explore PTGMS line purification and multipli- cation technology. [Method] Three commercial PTGMS lines, Annong 810S, P88S and C815S, were used in this study. In the first year, two sterile line populations with same genetic background were multiplied by dividing seedling; meanwhile, se- lection and multiplication of the core individuals were conducted; within the year, the core seeds harvested were multiplied under the isolated condition in Hainan, and at the same time, superior individuals were selected and used as the seeds for two populations with same genetic background in the next year. In the second year, seeds harvested in Hainan were planted in Changsha, while the core individuals were selected and multiplied; the core seeds harvested were continued to multiply in Hainan. The above procedures were repeated in the following years. [Result] The test results showed that in two years the proportion of core individuals in the popu- lation of Annong 810S, P88S and C815S increased from 40.3%, 0.7% and 0.3% in the first year to 71.67%, 66.00% and 68.67% in the second year respectively. [Conclusion] This suggested that this method of purification and multiplication of the PTGMS lines for consecutive years can effectively control the drift of the critical sterility inducing temperature, and at the same time, core seeds with high purity and controlled inducing temperature can be harvested.
基金The National Natural Science Foundation of China (No.60473029,60673072).
文摘To resist the side chaimel attacks of elliptic curve cryptography, a new fast and secure point multiplication algorithm is proposed. The algorithm is based on a particular kind of addition chains involving only additions, providing a natural protection against side channel attacks. Moreover, the new addition formulae that take into account the specific structure of those chains making point multiplication very efficient are proposed. The point multiplication algorithm only needs 1 719 multiplications for the SAC260 of 160-bit integers. For chains of length from 280 to 260, the proposed method outperforms all the previous methods with a gain of 26% to 31% over double-and add, 16% to22% over NAF, 7% to 13% over4-NAF and 1% to 8% over the present best algorithm--double-base chain.
基金Supported by the Natural Science Foundation of Hainan Province(313114)the Sanya Science Project(2013YD89)the Social Science Project(SYSK14-08)~~
文摘Based on winter nursery and shuttle breeding, Hainan National Breeding and Multiplication （HNBM）, with off-season breeding and seed production as the essence, has become a national strategic resource. The way of HNBM rising to the national strategy was analyzed through the aspects of technology features, historical characteristics, irreplaceability, function and value hierarchy, and the key problems. As the major achievement of the practice of scientific research and historical selec- tion, HNBM played an irreplaceable role in the climatic conditions, scientific breed- ing, and seed production in disaster relief, protecting the safety of the seed industry and Iocational advantages. Based on the analysis on the functions, values and ex- isted problems of HNBM, the function and value hierarchical structure of HNBM was established through introducing concepts of value engineering, industrial clusters and regional economy. But to fully achieve the industrial clustering development and functional values of HNBM, it needed to solve the key problems existed in top-level planning, experimental bases, system design, hardware construction and ecological security. Some suggestions were put forward in this paper, including setting up key scientific research protection zones, improving the regulations and policies safeguard mechanism and management system of HNBM, drawing up and carrying out the base development planning of HNBM, and striving for financial support from national policies.
基金Supported by the National Natural Science Foundation of China(11601400 and 11771441)the Fundamental Research Funds for the Central Universities(2017IB012 and 2017IVB064)
文摘This article is devoted to characterizing the boundedness and compactness of multiplication operators from Hardy spaces to weighted Bergman spaces in the unit ball of ■.
基金Supported by Technical Research and Development and Demonstration Promotion Fund of Beijing Vocational College of Agriculture(XY-YF-13-05)
文摘With the rhizomes obtained from the germination of Cymbidium sinense ~ Cymbidium goeringii seeds as a material, the effects of different basic media and different plant growth regulators on the multiplication and differentiation of rhizomes and rooting and transplanting of seedlings were investigated. The results showed that the basal medium more suitable for the multiplication and differentiation of rhizomes was 1/2MS; the medium more suitable for the multiplication and differentiation of rhizomes of the hybrid orchid was 1/2MS ＋ 6 - BA 2.0 mg/L ＋ KT 0.5 mg/L ＋ NAA 0.05 mg/L; the medium more suitable for the rooting of the hybrid orchid was 1/2MS ＋ IBA 0.5 mg/L; and after training of seedlings, transplanting was performed onto moss, and after 25 d, the survival rate was 95.6%.
基金supported by the Special Funding for Distinguished Researchers by Northeast Forestry University,China
文摘We developed a shoot multiplication protocol for Syringa reticulata Blume vat. mandshurica Hara from in vitro cultured seedlings that derived from in vitro germinated seeds. The shoots could be induced on Murashige and Skoog （MS） medium with proper plant growth regulator combinations of 6-benzylaminopurine （BA） and indole-3-butyric acid （IBA）. The better medium for shoot multiplication and growth was MS ＋ 5 mg L-1 BA ＋ 0.5 mg L-1 IBA ＋ 20 g L-1 sucrose ＋ 7 g L-1 agar, and the corresponding shoot induction rate was 75 %. The plantlets grew well after rooting on I/2MS medium （macro-elements of MS medium are at half-strength） sup- plemented with 1 mg L-1 IBA, and the survival percentage was 〉80 % at 16 weeks after transplanting.
