Background: Social determinants of health (SDOH) significantly influence diseases with environmental components, like vector-borne parasitic diseases. This study aims to examine how these factors influence vector-born...Background: Social determinants of health (SDOH) significantly influence diseases with environmental components, like vector-borne parasitic diseases. This study aims to examine how these factors influence vector-borne parasitic diseases (VBPDs) transmission in Chad and provide recommendations for policy improvements. Methods: The study adopts the WHO Conceptual Framework of SDOH to compare two regions in Southern Chad: Kouh-Est, which has an ongoing vector control program, and Grand-Sido, which lacks such a program. The study includes both nomadic and sedentary populations to provide a comprehensive understanding of the SDOH influencing VBPDs. Households were randomly selected. Data on sociodemographic characteristics, literacy, knowledge of VBPDs and protective measures, and access to education and health facilities were collected. Results: A total of 202 households from 17 villages, including 820 participants, were surveyed. Agriculture, livestock, and fishing were the main occupations, involving 84.1% of participants. Literacy was low, with 36.7% non-educated, 47.7% completing primary school, 14.5% secondary school, and only 0.3% reaching tertiary education. Most villages lacked schools beyond the primary level, and nomadic populations were significantly less educated than sedentary ones (p Conclusion: Educational deficiencies, lack of protective measures against vectors, inadequate healthcare resources, and lifestyle conditions aggravated by poor road infrastructure, limited transportation, and economic constraints contribute to worsened VBPDs outcomes in these rural populations. Addressing these systemic issues in the surveyed communities is essential for improving health equity and VBPDs outcomes in these regions specifically and in similar populations settings more broadly.展开更多
The notion of a sort of biorthogonal multiple vector-valued bivariate wavelet packets,which are associated with a quantity dilation matrix,is introduced.The biorthogonality property of the multiple vector-valued wavel...The notion of a sort of biorthogonal multiple vector-valued bivariate wavelet packets,which are associated with a quantity dilation matrix,is introduced.The biorthogonality property of the multiple vector-valued wavelet packets in higher dimensions is studied by means of Fourier transform and integral transform biorthogonality formulas concerning these wavelet packets are obtained.展开更多
This paper presents a method for seismic vulnerability analysis of bridge structures based on vector-valued intensity measure （viM）, which predicts the limit-state capacities efficiently with multi-intensity measure...This paper presents a method for seismic vulnerability analysis of bridge structures based on vector-valued intensity measure （viM）, which predicts the limit-state capacities efficiently with multi-intensity measures of seismic event. Accounting for the uncertainties of the bridge model, ten single-bent overpass bridge structures are taken as samples statistically using Latin hypercube sampling approach. 200 earthquake records are chosen randomly for the uncertainties of ground motions according to the site condition of the bridges. The uncertainties of structural capacity and seismic demand are evaluated with the ratios of demand to capacity in different damage state. By comparing the relative importance of different intensity measures, Sa（T1） and Sa（T2） are chosen as viM. Then, the vector-valued fragility functions of different bridge components are developed. Finally, the system-level vulnerability of the bridge based on viM is studied with Duunett- Sobel class correlation matrix which can consider the correlation effects of different bridge components. The study indicates that an increment IMs from a scalar IM to viM results in a significant reduction in the dispersion of fragility functions and in the uncertainties in evaluating earthquake risk. The feasibility and validity of the proposed vulnerability analysis method is validated and the bridge is more vulnerable than any components.展开更多
In this paper, the authors get the Coifman type weighted estimates and weak weighted LlogL estimates for vector-valued generalized commutators of multilinear fractional integral with w ∈ A∞. Furthermore, both the bo...In this paper, the authors get the Coifman type weighted estimates and weak weighted LlogL estimates for vector-valued generalized commutators of multilinear fractional integral with w ∈ A∞. Furthermore, both the boundedness of vector-valued multilinear frac- tional integral and the weak weighted LlogL estimates for vector-valued multilinear fractional integral are also obtained.展开更多
In this article, we consider the global chaotic synchronization of general cou- pled neural networks, in which subsystems have both discrete and distributed delays. Stochastic perturbations between subsystems are also...In this article, we consider the global chaotic synchronization of general cou- pled neural networks, in which subsystems have both discrete and distributed delays. Stochastic perturbations between subsystems are also considered. On the basis of two sim- ple adaptive pinning feedback control schemes, Lyapunov functional method, and stochas- tic analysis approach, several sufficient conditions are developed to guarantee global syn- chronization of the coupled neural networks with two kinds of delay couplings, even if only partial states of the nodes are coupled. The outer-coupling matrices may be symmetric or asymmetric. Unlike existing results that an isolate node is introduced as the pinning target, we pin to help the network realizing synchronization without introducing any iso- late node when the network is not synchronized. As a by product, sufficient conditions under which the network realizes synchronization without control are derived. Numerical simulations confirm the effectiveness of the obtained results.展开更多
Based on a full vector-diffraction theory, a detailed theoretical study is carried out, aiming at providing a clear insight into the effects of different focusing and off-axis parabola parameters on far-field vector-d...Based on a full vector-diffraction theory, a detailed theoretical study is carried out, aiming at providing a clear insight into the effects of different focusing and off-axis parabola parameters on far-field vector-diffraction properties of an offaxis parabolic mirror in the presence of misalignments of the incoming beam. The physical origin of these effects is also explored. The results show that the far-field intensity profile is altered by the distortion-, coma-, and astigmatism-like aberrations, which are caused by oblique incidence rather than inherent aberrations for the off-axis configuration. The radius of 90% encircled energy also increases but does not change monotonically with incident beam size increasing, or rather,it first decreases and then increases. The focal shift strongly depends on the effective focal length and oblique incidence angle, but it is almost independent of the beam size, which affects the focusing spot patterns. The intensity distribution produces a higher astigmatic image with off-axis angle increasing. Coma-like aberration starts to become dominant with beam size increasing and results in larger curved propagation trajectory. The incident polarization also affects the intensity distribution. The variation in the Strehl ratio with oblique incidence angle strongly depends on the misalignment direction and beam size as well. In addition, we find that the difference in locus between the catacaustic and the diffraction focus in the meridian is small. But the locus of the sagittal foci is obviously different from the locus of the meridian foci and the catacaustic focus. Moreover, the peak intensity of the sagittal focus is maximum, and the ratio of the peak intensity to that in the meridian plane is approximately 1.5. Understanding these effects is valuable for assessing a practical focused intensity and describing the motion of charged particles under a strong electric field in ultraintense laser–matter interaction.展开更多
In this article, we consider a class of compound vector-valued problem on upper-half plane C＋, which consists of vector Riemann problem along a closed contour in C＋ with matrix coefficient in H61der class and vector...In this article, we consider a class of compound vector-valued problem on upper-half plane C＋, which consists of vector Riemann problem along a closed contour in C＋ with matrix coefficient in H61der class and vector Hilbert problem on the real axis with essential bounded measurable matrix coefficient. Under appropriate assumption we obtain its solution by use of Corona theorem and factorization of matrix functions in decomposed Banach algebras.展开更多
Objective:To evaluate the Anaplasma phagocytophilum(A.phagocytophilum),Ehrlichia canis(E.canis,Dirofilaria immitis(D.immitis)(canine heartworm),Borrelia burgdorferi(B.burgdorferi)infections in countryside dogs from Yu...Objective:To evaluate the Anaplasma phagocytophilum(A.phagocytophilum),Ehrlichia canis(E.canis,Dirofilaria immitis(D.immitis)(canine heartworm),Borrelia burgdorferi(B.burgdorferi)infections in countryside dogs from Yunnan,Hainan and Anhui provinces.Methods:Serum samples were collected from 26 dogs in Yunnan.Hainan and Anhui provinces.The samples were tested using a commercial ELISA rapid diagnostic assay kit(SNAP^(?)4Dx^(?);IDEXX Laboratories,Inc.U.S.A.).Meaiiwliile,indirect immunofluorescence assay(IFA)recommended by WHO was conducted to delect IgG to A.phagocytophilum.Two methods were analyzed and compared.Results:The number of serologically positive dogs for IgG to A.phagocytophilum was only 2which was from Hainan province and none of the 26 dogs responded positive for E.canu.D.immitis(canine heartworm,and B.burgdorferi by ELISA rapid diagnostic method.The number of serologically positive dogs for IgG to A.phagocytophilum was 13(50%)by IFA method.Data of the two methods were analyzed by statistical software and the difference was statistically significant(P=0.002).Conclusions:It can be concluded that IFA method was more sensitive than ELISA rapid diagnostic method.However,we need conduct further and intensive epidemiology survey on tick-born diseases pathogens including.4.phagocytophilum,E.canis,D.immitis(canine heartworm),and B.burgdorferi which have public health significance.展开更多
In this paper, the source localization by utilizing the measurements of a single electromagnetic （EM） vector-sensor is investigated in the framework of the geometric algebra of Euclidean 3-space. In order to describ...In this paper, the source localization by utilizing the measurements of a single electromagnetic （EM） vector-sensor is investigated in the framework of the geometric algebra of Euclidean 3-space. In order to describe the orthogonality among the electric and magnetic measurements, two multivectors of the geometric algebra of Euclidean 3-space （G3） are used to model the outputs of a spatially collocated EM vector-sensor. Two estimators for the wave propagation vector estimation are then formulated by the inner product between a vector and a bivector in the G3. Since the information used by the two estimators is different, a weighted inner product estimator is then proposed to fuse the two estimators together in the sense of the minimum mean square error （MMSE）. Analytical results show that the statistical performances of the weighted inner product estimator are always better than its traditional cross product counterpart. The efficacy of the weighted inner product estimator and the correctness of the analytical predictions are demonstrated by simulation results.展开更多
This paper proposes a vector-borne plant disease model with discontinuous treatment strategies. Constructing Lyapunov function and applying non-smooth theory to analyze discontinuous differential equations, the basic ...This paper proposes a vector-borne plant disease model with discontinuous treatment strategies. Constructing Lyapunov function and applying non-smooth theory to analyze discontinuous differential equations, the basic reproductive number R0 is proved, which determines whether the plant disease will be extinct or not. If R0 R0 > 1 , there exists a unique endemic equilibrium which is globally stable. The numerical simulations are provided to verify our theoretical results, which indicate that after infective individuals reach some level, strengthening treatment measures is proved to be beneficial in controlling disease transmission.展开更多
Let φ be an analytic self-map of the complex unit disk and X a Banach space. This paper studies the action of composition operator Cφ： f→foφ on the vector-valued Nevanlinna classes N（X） and Na（X）. Certain cri...Let φ be an analytic self-map of the complex unit disk and X a Banach space. This paper studies the action of composition operator Cφ： f→foφ on the vector-valued Nevanlinna classes N（X） and Na（X）. Certain criteria for such operators to be weakly compact are given. As a consequence, this paper shows that the composition operator Cφ is weakly compact on N（X） and Na（X） if and only if it is weakly compact on the vector-valued Hardy space H^1 （X） and Bergman space B1（X） respectively.展开更多
In the presence of spin and pseudospin （p-spin） symmetries, the approximate analytical bound states of the Dirac equation for scalar-vector-tensor Hulth6n potentials are obtained with any arbitrary spin-orbit coupli...In the presence of spin and pseudospin （p-spin） symmetries, the approximate analytical bound states of the Dirac equation for scalar-vector-tensor Hulth6n potentials are obtained with any arbitrary spin-orbit coupling number using the Pekeris approximation. The Hulth6n tensor interaction is studied instead of the commonly used Coulomb or linear terms. The generalized parametric Nikiforov-Uvarov （NU） method is used to obtain energy eigenvalues and corresponding wave functions in their closed forms. It is shown that tensor interaction removes degeneracy between spin and p-spin doublets. Some numerical results are also given.展开更多
In this paper, we have rigorously analyzed a model to find the effective control strategies on the transmission dynamics of a vector-borne disease. It is proved that the global dynamics of the disease are completely d...In this paper, we have rigorously analyzed a model to find the effective control strategies on the transmission dynamics of a vector-borne disease. It is proved that the global dynamics of the disease are completely determined by the basic reproduction number. The numerical simulations (using MatLab and Maple) of the model reveal that the precautionary measures at the aquatic and adult stage decrease the number of new cases of dengue virus. Numerical simulation indicates that if we take the precautionary measures seriously then it would be more effective than even giving the treatment to the infected individuals.展开更多
Vector-borne diseases are highly sensitive to environment and to environmental changes. Rift Valley Fever (RFV) is a mosquito-borne zootic virus associated with severe diseases in human beings and economic consequence...Vector-borne diseases are highly sensitive to environment and to environmental changes. Rift Valley Fever (RFV) is a mosquito-borne zootic virus associated with severe diseases in human beings and economic consequences to livestock sector. Animal and human movements have a fundamental impact on RVF transmission. In recent years, there has been a growing interest in the use of mathematics and agent based models to represent and analyze the dynamic of RFV transmission. However, no previous study has taken into consideration animal herds’ mobility and precipitation factors to understand the disease spread. This limitation underlines the necessity to use computational model approach based on multi-agent system in the study of vector-borne diseases transmission and diffusion. In this paper, a multi-agent system combining conceptual model expressiveness is used to study animal herds’ mobility and the precipitation parameter impact on the Rift Valley Fever outbreak in Ferlo Barkedji in Northern Senegal. Simulation scenarios with various parameters, including rain quality, hosts, vectors, camp dispersal around ponds, etc., are unrolled. The different results we have obtained show that the evolution of the number of infected hosts and infected vectors depend on the degree of animal herds’ mobility and on precipitations. Our model provides a framework that permits predicting the spread of the disease associated with the mobility of animal herds.展开更多
Under assumption of existence of extremely large gravitational vector field, this paper proposes a road map for building an Axiomatic Eddington Affine Unification theory yielding both Maxwell’s electromagnetism and V...Under assumption of existence of extremely large gravitational vector field, this paper proposes a road map for building an Axiomatic Eddington Affine Unification theory yielding both Maxwell’s electromagnetism and Vector-metric theory of gravitation, in which inverse of the square-magnitude of the vector serves as Newton’s gravitational constant. The dependence of the vector’s magnitude with distance may offer an explanation of both Pioneer anomaly and “star rotation abnormality” in some Galaxies. In addition, the theory provides formalism for a classical description of atomic particles (such as protons and electrons) with highly non-linear equations and highly localized solutions. The existence of large Gravitational vector field can, for some variables (sub-fields), lead to elliptical type?differential equations (unlike in Maxwell’s electromagnetism, which is hyperbolic ), that by its nature forbids the existence independent waves and their propagation. Proposed Unified field description might provide the avenue for smooth transition to the world Quantum physics.展开更多
OBJECTIVE： In the present study, we systemically evaluated the ability of two bioactive compounds from traditional Chinese medicine, celastrol and pristimerin, to enhance recombinant adeno-associated virus （rAAV） s...OBJECTIVE： In the present study, we systemically evaluated the ability of two bioactive compounds from traditional Chinese medicine, celastrol and pristimerin, to enhance recombinant adeno-associated virus （rAAV） serotype vector-mediated transgene expression both in human cell lines in vitro, and in murine hepatocytes in vivo. METHODS： Human cell lines were infected with rAAV vectors with either mock treatment or treatment with celastrol or pristimerin. The transgene expression, percentage of nuclear translocated viral genomes and the ubiquitination of intracellular proteins were investigated post-treatment. In addition, nonobese diabetic/severe combined immunodeficient gamma （NSG） mice were tail vain-injected with rAAV vectors and co-administered with either dimethyl sulfoxide, celastrol, pristimerin or a positive control, bortezomib. The transgene expression in liver was detected and compared over time. RESULTS： We observed that treatment with pristimerin, at as low as 1 IJmol/L concentration, significantly enhanced rAAV2 vector-mediated transgene expression in vitro, and intraperitoneal co- administration with pristimerin at 4 mg/（kg.d） for 3 d dramatically facilitated viral transduction in murine hepatocytes in vivo. The transduction efficiency of the tyrosine-mutant rAAV2 vectors as well as that of rAAV8 vectors carrying oversized transgene cassette was also augmented significantly by pristimerin. The underlying molecular mechanisms by which pristimerin mediated the observed increase in the transduction efficiency of rAAV vectors include both inhibition of proteasomal degradation of the intracellular proteins and enhanced nuclear translocation of the vector genomes. CONCLUSION： These studies suggest the potential beneficial use of pristimerin and pristimerincontaining herb extract in future liver-targeted gene therapy with rAAV vectors.展开更多
We obtained a number of inequalities and laws of large numbers for two parameter vector valued martingales.In the other direction we characterized p smoothness and q convexity of Banach spaces by using the...We obtained a number of inequalities and laws of large numbers for two parameter vector valued martingales.In the other direction we characterized p smoothness and q convexity of Banach spaces by using these inequalities and laws of large numbers for two parameter vector valued martingales.展开更多
BACKGROUND:Systemic administration of CTLA4Ig has been applied in inducing immunological tolerance of hepatocyte implants,but has potential for systemic immune inhibition.This study was designed to induce hepatocyte i...BACKGROUND:Systemic administration of CTLA4Ig has been applied in inducing immunological tolerance of hepatocyte implants,but has potential for systemic immune inhibition.This study was designed to induce hepatocyte immunological tolerance by locally expressing CTLA4Ig in an attempt to improve the effectiveness of cell transplantation.METHODS:A normal human liver cell line(L02) was transfected with adenovirus vector containing the CTLA4Ig gene(Ad-CTLA4Ig-EGFP) in vitro,and the expression of CTLA4Ig by transfected cells was assessed by fluorescent imaging and immunocytochemical staining.Transfected cells then were injected into the spleen of Sprague-Dawley rats,the survival of cells was determined by immunohistochemistry,and the immune status was examined through CD4 + and CD69 + T cellcounts and ELISA detection of IL-2 in peripheral blood.RESULTS:L02 cells expressed CTLA4Ig in the cytoplasm for >4 weeks.Surviving L02 cells were observed in the experimental group at 3 and 4 weeks post-transplantation,while none was detected in the control group.Furthermore,the percentages of CD4 + and CD4 + CD69 + T cells in the CTLA4-transfected group were 24.5% and 45.1%,markedly lower than those in the control group at 4 weeks post-transplantation(P<0.01).Furthermore,the IL-2 level was also lower in the CTLA4transfected group than in the control group.CONCLUSION:Adenovirus-mediated CTLA4Ig gene transfer into human hepatocytes has the potential to become an effective method of inducing immunological tolerance in hepatocyte transplantation.展开更多
Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons, even leading to the permanent loss of function. Gene therapy via gene replacement or ...Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons, even leading to the permanent loss of function. Gene therapy via gene replacement or gene correction provides the potential for transformative therapies to delay or possibly stop further progression of the neurodegenerative disease in affected patients. Adeno-associated virus has been the vector of choice in recent clinical trials of therapies for neurodegenerative diseases due to its safety and efficiency in mediating gene transfer to the central nervous system. This review aims to discuss and summarize the progress and clinical applications of adeno-associated virus in neurodegenerative disease in central nervous system. Results from some clinical trials and successful cases of central neurodegenerative diseases deserve further study and exploration.展开更多
文摘Background: Social determinants of health (SDOH) significantly influence diseases with environmental components, like vector-borne parasitic diseases. This study aims to examine how these factors influence vector-borne parasitic diseases (VBPDs) transmission in Chad and provide recommendations for policy improvements. Methods: The study adopts the WHO Conceptual Framework of SDOH to compare two regions in Southern Chad: Kouh-Est, which has an ongoing vector control program, and Grand-Sido, which lacks such a program. The study includes both nomadic and sedentary populations to provide a comprehensive understanding of the SDOH influencing VBPDs. Households were randomly selected. Data on sociodemographic characteristics, literacy, knowledge of VBPDs and protective measures, and access to education and health facilities were collected. Results: A total of 202 households from 17 villages, including 820 participants, were surveyed. Agriculture, livestock, and fishing were the main occupations, involving 84.1% of participants. Literacy was low, with 36.7% non-educated, 47.7% completing primary school, 14.5% secondary school, and only 0.3% reaching tertiary education. Most villages lacked schools beyond the primary level, and nomadic populations were significantly less educated than sedentary ones (p Conclusion: Educational deficiencies, lack of protective measures against vectors, inadequate healthcare resources, and lifestyle conditions aggravated by poor road infrastructure, limited transportation, and economic constraints contribute to worsened VBPDs outcomes in these rural populations. Addressing these systemic issues in the surveyed communities is essential for improving health equity and VBPDs outcomes in these regions specifically and in similar populations settings more broadly.
基金Supported by Natural Science Foundation of Henan Province（0511013500）
文摘The notion of a sort of biorthogonal multiple vector-valued bivariate wavelet packets,which are associated with a quantity dilation matrix,is introduced.The biorthogonality property of the multiple vector-valued wavelet packets in higher dimensions is studied by means of Fourier transform and integral transform biorthogonality formulas concerning these wavelet packets are obtained.
基金National Program on Key Basic Research Project of China(973)under Grant No.2011CB013603National Natural Science Foundation of China under Grant Nos.51378341,91315301Tianjin Municipal Natural Science Foundation under Grant No.13JCQNJC07200
文摘This paper presents a method for seismic vulnerability analysis of bridge structures based on vector-valued intensity measure （viM）, which predicts the limit-state capacities efficiently with multi-intensity measures of seismic event. Accounting for the uncertainties of the bridge model, ten single-bent overpass bridge structures are taken as samples statistically using Latin hypercube sampling approach. 200 earthquake records are chosen randomly for the uncertainties of ground motions according to the site condition of the bridges. The uncertainties of structural capacity and seismic demand are evaluated with the ratios of demand to capacity in different damage state. By comparing the relative importance of different intensity measures, Sa（T1） and Sa（T2） are chosen as viM. Then, the vector-valued fragility functions of different bridge components are developed. Finally, the system-level vulnerability of the bridge based on viM is studied with Duunett- Sobel class correlation matrix which can consider the correlation effects of different bridge components. The study indicates that an increment IMs from a scalar IM to viM results in a significant reduction in the dispersion of fragility functions and in the uncertainties in evaluating earthquake risk. The feasibility and validity of the proposed vulnerability analysis method is validated and the bridge is more vulnerable than any components.
基金Supported by the National Natural Science Foundation of China(11271330,11226104,11226108)the Jiangxi Natural Science Foundation of China(20114BAB211007)the Science Foundation of Jiangxi Education Department(GJJ13703)
文摘In this paper, the authors get the Coifman type weighted estimates and weak weighted LlogL estimates for vector-valued generalized commutators of multilinear fractional integral with w ∈ A∞. Furthermore, both the boundedness of vector-valued multilinear frac- tional integral and the weak weighted LlogL estimates for vector-valued multilinear fractional integral are also obtained.
基金supported by the National Natural Science Foundation of China under Grant No. 60874088 and No. 11072059the Scientific Research Fund of Yunnan Province under Grant No. 2010ZC150the Scientific Research Fund of Yunnan Provincial Education Department under Grant No. 07Y10085
文摘In this article, we consider the global chaotic synchronization of general cou- pled neural networks, in which subsystems have both discrete and distributed delays. Stochastic perturbations between subsystems are also considered. On the basis of two sim- ple adaptive pinning feedback control schemes, Lyapunov functional method, and stochas- tic analysis approach, several sufficient conditions are developed to guarantee global syn- chronization of the coupled neural networks with two kinds of delay couplings, even if only partial states of the nodes are coupled. The outer-coupling matrices may be symmetric or asymmetric. Unlike existing results that an isolate node is introduced as the pinning target, we pin to help the network realizing synchronization without introducing any iso- late node when the network is not synchronized. As a by product, sufficient conditions under which the network realizes synchronization without control are derived. Numerical simulations confirm the effectiveness of the obtained results.
基金Project supported by the Science Foundation for Youth Scholars of Minjiang University,China(Grant No.Mj9n201602)the National Science and Technology Major Project of the Ministry of Science and Technology of China。
文摘Based on a full vector-diffraction theory, a detailed theoretical study is carried out, aiming at providing a clear insight into the effects of different focusing and off-axis parabola parameters on far-field vector-diffraction properties of an offaxis parabolic mirror in the presence of misalignments of the incoming beam. The physical origin of these effects is also explored. The results show that the far-field intensity profile is altered by the distortion-, coma-, and astigmatism-like aberrations, which are caused by oblique incidence rather than inherent aberrations for the off-axis configuration. The radius of 90% encircled energy also increases but does not change monotonically with incident beam size increasing, or rather,it first decreases and then increases. The focal shift strongly depends on the effective focal length and oblique incidence angle, but it is almost independent of the beam size, which affects the focusing spot patterns. The intensity distribution produces a higher astigmatic image with off-axis angle increasing. Coma-like aberration starts to become dominant with beam size increasing and results in larger curved propagation trajectory. The incident polarization also affects the intensity distribution. The variation in the Strehl ratio with oblique incidence angle strongly depends on the misalignment direction and beam size as well. In addition, we find that the difference in locus between the catacaustic and the diffraction focus in the meridian is small. But the locus of the sagittal foci is obviously different from the locus of the meridian foci and the catacaustic focus. Moreover, the peak intensity of the sagittal focus is maximum, and the ratio of the peak intensity to that in the meridian plane is approximately 1.5. Understanding these effects is valuable for assessing a practical focused intensity and describing the motion of charged particles under a strong electric field in ultraintense laser–matter interaction.
基金supported by the National Natural Science Foundation of China(10471107)RFDP of Higher Education(20060486001)
文摘In this article, we consider a class of compound vector-valued problem on upper-half plane C＋, which consists of vector Riemann problem along a closed contour in C＋ with matrix coefficient in H61der class and vector Hilbert problem on the real axis with essential bounded measurable matrix coefficient. Under appropriate assumption we obtain its solution by use of Corona theorem and factorization of matrix functions in decomposed Banach algebras.
基金supported by the National Basic Research Program of China(973 Program)2010CB530200(2010CB530206)the China-US Collaborative Program on Emerging and Re-emerging Infectious Disease(No.1U2GGH000018-01)
文摘Objective:To evaluate the Anaplasma phagocytophilum(A.phagocytophilum),Ehrlichia canis(E.canis,Dirofilaria immitis(D.immitis)(canine heartworm),Borrelia burgdorferi(B.burgdorferi)infections in countryside dogs from Yunnan,Hainan and Anhui provinces.Methods:Serum samples were collected from 26 dogs in Yunnan.Hainan and Anhui provinces.The samples were tested using a commercial ELISA rapid diagnostic assay kit(SNAP^(?)4Dx^(?);IDEXX Laboratories,Inc.U.S.A.).Meaiiwliile,indirect immunofluorescence assay(IFA)recommended by WHO was conducted to delect IgG to A.phagocytophilum.Two methods were analyzed and compared.Results:The number of serologically positive dogs for IgG to A.phagocytophilum was only 2which was from Hainan province and none of the 26 dogs responded positive for E.canu.D.immitis(canine heartworm,and B.burgdorferi by ELISA rapid diagnostic method.The number of serologically positive dogs for IgG to A.phagocytophilum was 13(50%)by IFA method.Data of the two methods were analyzed by statistical software and the difference was statistically significant(P=0.002).Conclusions:It can be concluded that IFA method was more sensitive than ELISA rapid diagnostic method.However,we need conduct further and intensive epidemiology survey on tick-born diseases pathogens including.4.phagocytophilum,E.canis,D.immitis(canine heartworm),and B.burgdorferi which have public health significance.
基金National Natural Science Foundation of China(61171127)National Basic Research Program of China(2011CB302903)
文摘In this paper, the source localization by utilizing the measurements of a single electromagnetic （EM） vector-sensor is investigated in the framework of the geometric algebra of Euclidean 3-space. In order to describe the orthogonality among the electric and magnetic measurements, two multivectors of the geometric algebra of Euclidean 3-space （G3） are used to model the outputs of a spatially collocated EM vector-sensor. Two estimators for the wave propagation vector estimation are then formulated by the inner product between a vector and a bivector in the G3. Since the information used by the two estimators is different, a weighted inner product estimator is then proposed to fuse the two estimators together in the sense of the minimum mean square error （MMSE）. Analytical results show that the statistical performances of the weighted inner product estimator are always better than its traditional cross product counterpart. The efficacy of the weighted inner product estimator and the correctness of the analytical predictions are demonstrated by simulation results.
文摘This paper proposes a vector-borne plant disease model with discontinuous treatment strategies. Constructing Lyapunov function and applying non-smooth theory to analyze discontinuous differential equations, the basic reproductive number R0 is proved, which determines whether the plant disease will be extinct or not. If R0 R0 > 1 , there exists a unique endemic equilibrium which is globally stable. The numerical simulations are provided to verify our theoretical results, which indicate that after infective individuals reach some level, strengthening treatment measures is proved to be beneficial in controlling disease transmission.
文摘Let φ be an analytic self-map of the complex unit disk and X a Banach space. This paper studies the action of composition operator Cφ： f→foφ on the vector-valued Nevanlinna classes N（X） and Na（X）. Certain criteria for such operators to be weakly compact are given. As a consequence, this paper shows that the composition operator Cφ is weakly compact on N（X） and Na（X） if and only if it is weakly compact on the vector-valued Hardy space H^1 （X） and Bergman space B1（X） respectively.
文摘In the presence of spin and pseudospin （p-spin） symmetries, the approximate analytical bound states of the Dirac equation for scalar-vector-tensor Hulth6n potentials are obtained with any arbitrary spin-orbit coupling number using the Pekeris approximation. The Hulth6n tensor interaction is studied instead of the commonly used Coulomb or linear terms. The generalized parametric Nikiforov-Uvarov （NU） method is used to obtain energy eigenvalues and corresponding wave functions in their closed forms. It is shown that tensor interaction removes degeneracy between spin and p-spin doublets. Some numerical results are also given.
文摘In this paper, we have rigorously analyzed a model to find the effective control strategies on the transmission dynamics of a vector-borne disease. It is proved that the global dynamics of the disease are completely determined by the basic reproduction number. The numerical simulations (using MatLab and Maple) of the model reveal that the precautionary measures at the aquatic and adult stage decrease the number of new cases of dengue virus. Numerical simulation indicates that if we take the precautionary measures seriously then it would be more effective than even giving the treatment to the infected individuals.
文摘Vector-borne diseases are highly sensitive to environment and to environmental changes. Rift Valley Fever (RFV) is a mosquito-borne zootic virus associated with severe diseases in human beings and economic consequences to livestock sector. Animal and human movements have a fundamental impact on RVF transmission. In recent years, there has been a growing interest in the use of mathematics and agent based models to represent and analyze the dynamic of RFV transmission. However, no previous study has taken into consideration animal herds’ mobility and precipitation factors to understand the disease spread. This limitation underlines the necessity to use computational model approach based on multi-agent system in the study of vector-borne diseases transmission and diffusion. In this paper, a multi-agent system combining conceptual model expressiveness is used to study animal herds’ mobility and the precipitation parameter impact on the Rift Valley Fever outbreak in Ferlo Barkedji in Northern Senegal. Simulation scenarios with various parameters, including rain quality, hosts, vectors, camp dispersal around ponds, etc., are unrolled. The different results we have obtained show that the evolution of the number of infected hosts and infected vectors depend on the degree of animal herds’ mobility and on precipitations. Our model provides a framework that permits predicting the spread of the disease associated with the mobility of animal herds.
文摘Under assumption of existence of extremely large gravitational vector field, this paper proposes a road map for building an Axiomatic Eddington Affine Unification theory yielding both Maxwell’s electromagnetism and Vector-metric theory of gravitation, in which inverse of the square-magnitude of the vector serves as Newton’s gravitational constant. The dependence of the vector’s magnitude with distance may offer an explanation of both Pioneer anomaly and “star rotation abnormality” in some Galaxies. In addition, the theory provides formalism for a classical description of atomic particles (such as protons and electrons) with highly non-linear equations and highly localized solutions. The existence of large Gravitational vector field can, for some variables (sub-fields), lead to elliptical type?differential equations (unlike in Maxwell’s electromagnetism, which is hyperbolic ), that by its nature forbids the existence independent waves and their propagation. Proposed Unified field description might provide the avenue for smooth transition to the world Quantum physics.
基金supported in part by the Alex's Lemonade Foundation,and Bankhead-Coley Cancer Research Program,Florida Department of Health(to CL), Public Health Service grants R01 HL-097088 and R21 EB-015684 from the National Institutes of Health,and an institutional grant from the Children's Miracle Network (to AS,CL and GA)supported in part by the state-sponsored program for Graduate Students from China Scholarship Council,Government of China, and the National Natural Science Foundation of China (No.30730114)
文摘OBJECTIVE： In the present study, we systemically evaluated the ability of two bioactive compounds from traditional Chinese medicine, celastrol and pristimerin, to enhance recombinant adeno-associated virus （rAAV） serotype vector-mediated transgene expression both in human cell lines in vitro, and in murine hepatocytes in vivo. METHODS： Human cell lines were infected with rAAV vectors with either mock treatment or treatment with celastrol or pristimerin. The transgene expression, percentage of nuclear translocated viral genomes and the ubiquitination of intracellular proteins were investigated post-treatment. In addition, nonobese diabetic/severe combined immunodeficient gamma （NSG） mice were tail vain-injected with rAAV vectors and co-administered with either dimethyl sulfoxide, celastrol, pristimerin or a positive control, bortezomib. The transgene expression in liver was detected and compared over time. RESULTS： We observed that treatment with pristimerin, at as low as 1 IJmol/L concentration, significantly enhanced rAAV2 vector-mediated transgene expression in vitro, and intraperitoneal co- administration with pristimerin at 4 mg/（kg.d） for 3 d dramatically facilitated viral transduction in murine hepatocytes in vivo. The transduction efficiency of the tyrosine-mutant rAAV2 vectors as well as that of rAAV8 vectors carrying oversized transgene cassette was also augmented significantly by pristimerin. The underlying molecular mechanisms by which pristimerin mediated the observed increase in the transduction efficiency of rAAV vectors include both inhibition of proteasomal degradation of the intracellular proteins and enhanced nuclear translocation of the vector genomes. CONCLUSION： These studies suggest the potential beneficial use of pristimerin and pristimerincontaining herb extract in future liver-targeted gene therapy with rAAV vectors.
文摘We obtained a number of inequalities and laws of large numbers for two parameter vector valued martingales.In the other direction we characterized p smoothness and q convexity of Banach spaces by using these inequalities and laws of large numbers for two parameter vector valued martingales.
基金supported by a grant from the National Basic Research of China(973 Program 2007CB512903)
文摘BACKGROUND:Systemic administration of CTLA4Ig has been applied in inducing immunological tolerance of hepatocyte implants,but has potential for systemic immune inhibition.This study was designed to induce hepatocyte immunological tolerance by locally expressing CTLA4Ig in an attempt to improve the effectiveness of cell transplantation.METHODS:A normal human liver cell line(L02) was transfected with adenovirus vector containing the CTLA4Ig gene(Ad-CTLA4Ig-EGFP) in vitro,and the expression of CTLA4Ig by transfected cells was assessed by fluorescent imaging and immunocytochemical staining.Transfected cells then were injected into the spleen of Sprague-Dawley rats,the survival of cells was determined by immunohistochemistry,and the immune status was examined through CD4 + and CD69 + T cellcounts and ELISA detection of IL-2 in peripheral blood.RESULTS:L02 cells expressed CTLA4Ig in the cytoplasm for >4 weeks.Surviving L02 cells were observed in the experimental group at 3 and 4 weeks post-transplantation,while none was detected in the control group.Furthermore,the percentages of CD4 + and CD4 + CD69 + T cells in the CTLA4-transfected group were 24.5% and 45.1%,markedly lower than those in the control group at 4 weeks post-transplantation(P<0.01).Furthermore,the IL-2 level was also lower in the CTLA4transfected group than in the control group.CONCLUSION:Adenovirus-mediated CTLA4Ig gene transfer into human hepatocytes has the potential to become an effective method of inducing immunological tolerance in hepatocyte transplantation.
文摘Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons, even leading to the permanent loss of function. Gene therapy via gene replacement or gene correction provides the potential for transformative therapies to delay or possibly stop further progression of the neurodegenerative disease in affected patients. Adeno-associated virus has been the vector of choice in recent clinical trials of therapies for neurodegenerative diseases due to its safety and efficiency in mediating gene transfer to the central nervous system. This review aims to discuss and summarize the progress and clinical applications of adeno-associated virus in neurodegenerative disease in central nervous system. Results from some clinical trials and successful cases of central neurodegenerative diseases deserve further study and exploration.
