Fish (Rita rita) were exposed to an anionic detergent, dodecylbenzene sodium sulfonate, at a concentration of 6.9mg/liter (96-hr LC_(50) of the detergent).A series of histochemical techniques, used in this study for t...Fish (Rita rita) were exposed to an anionic detergent, dodecylbenzene sodium sulfonate, at a concentration of 6.9mg/liter (96-hr LC_(50) of the detergent).A series of histochemical techniques, used in this study for the demonstration of various protein constituents, indicated a gradual decrease in the intensity of staining reactions of the cytoplasmic material, suggesting a loss of protein moieties from the club cells and the epithelial cells of the opercular epidermis as a result of detergent exposure. 1990 Academic Press.Inc.展开更多
Rita rita exposed to a concentration of 6.9 mg per liter(96-h LC_(50)of an anionic detergent, dodecylbenzene sodium sulfonate)exhibited a gradual decrease in the lipid moieties of the epi- thelial cells,club cells,and...Rita rita exposed to a concentration of 6.9 mg per liter(96-h LC_(50)of an anionic detergent, dodecylbenzene sodium sulfonate)exhibited a gradual decrease in the lipid moieties of the epi- thelial cells,club cells,and goblet mucous cells lining the gill arch and gill filament epithelium. However,in time,no reaction of any of the lipid moieties could be observed,indicating the absence of the same,using various histochemical techniques.The results are discussed in light of the mechanistic understanding of detergent action.1989 Academic Press,Inc.展开更多
Sliding is one of the principal failure types of caisson breakwaters and is an essential content of stability examination in caisson breakwater design. Herein, the mass-spring-dashpot model of caisson-base system is u...Sliding is one of the principal failure types of caisson breakwaters and is an essential content of stability examination in caisson breakwater design. Herein, the mass-spring-dashpot model of caisson-base system is used to simulate the vibrating-sliding motion of the caisson under various types of breaking wave impact forces, i.e., single peak impact force, double peak impact force, and shock-damping oscillation impact force. The effects of various breaking wave impacts and the sliding motion on the dynamic response behaviors of caisson breakwaters are investigated and the calculation of relevant system parameters is discussed. It is shown that the dynamic responses of the caisson are significantly different under different types of breaking wave impact forces even when the amplitudes of impact forces are equal. The amplitude of dynamic response of the caisson is lower under single peak impact excitation than that under double peak impact or shock-damping oscillation impact excitation. Though the displacement of the caisson is large due to sliding, the rotation, the sliding force and the overturning moment of the caisson are significantly reduced.展开更多
Craniofacial development relies on the migration of cranial neural crest cells(CNCCs)to the first and second pharyngeal arches,followed by their differentiation into various cell types during embryogenesis.Although th...Craniofacial development relies on the migration of cranial neural crest cells(CNCCs)to the first and second pharyngeal arches,followed by their differentiation into various cell types during embryogenesis.Although the CNCC migration has been well-studied,the role of the niche in relation to CNCC remains unclear.Variants in FOXI3 have been implicated in craniofacial microsomia(CFM),yet the molecular mechanisms remain unexplored.FOXI3 is expressed in the ectoderm and auricle epidermis,but not in CNCCs or cartilage.Deletion of Foxi3 in the mouse CNCCs did not disrupt mandible and auricular development,further confirming that FOXI3 does not directly regulate CNCCs.However,Foxi3 deficiency in the ectoderm reduced the production of chondrogenesis-related cytokines derived from ectodermal cells,such as TGF-β1.This impairment affected CNCC proliferation through cell communication,subsequently altering the development of the mandible and auricle.These results emphasize the critical role of FOXI3 in establishing the microenvironment supporting CNCC function.Furthermore,FOXI3 directly regulates target genes associated with translation,thereby orchestrating cytokine production in epidermal cells.The validation using auricle sample from a CFM patient carrying FOXI3 mutation further supports our findings.These insights highlight the function of FOXI3 in creating the niche necessary for CNCC development and provide a basis for understanding the molecular mechanisms driving CFM pathogenesis.展开更多
Generally Fibonacci series and Lucas series are the same, they converge to golden ratio. After I read Fibonacci series, I thought, is there or are there any series which converges to golden ratio. Because of that I ex...Generally Fibonacci series and Lucas series are the same, they converge to golden ratio. After I read Fibonacci series, I thought, is there or are there any series which converges to golden ratio. Because of that I explored the inter relations of Fibonacci series when I was intent on Fibonacci series in my difference parallelogram. In which, I found there is no degeneration on Fibonacci series. In my thought, Pascal triangle seemed like a lower triangular matrix, so I tried to find the inverse for that. In inverse form, there is no change against original form of Pascal elements matrix. One day I played with ring magnets, which forms hexagonal shapes. Number of rings which forms Hexagonal shape gives Hex series. In this paper, I give the general formula for generating various types of Fibonacci series and its non-degeneration, how Pascal elements maintain its identities and which shapes formed by hex numbers by difference and matrices.展开更多
文摘Fish (Rita rita) were exposed to an anionic detergent, dodecylbenzene sodium sulfonate, at a concentration of 6.9mg/liter (96-hr LC_(50) of the detergent).A series of histochemical techniques, used in this study for the demonstration of various protein constituents, indicated a gradual decrease in the intensity of staining reactions of the cytoplasmic material, suggesting a loss of protein moieties from the club cells and the epithelial cells of the opercular epidermis as a result of detergent exposure. 1990 Academic Press.Inc.
文摘Rita rita exposed to a concentration of 6.9 mg per liter(96-h LC_(50)of an anionic detergent, dodecylbenzene sodium sulfonate)exhibited a gradual decrease in the lipid moieties of the epi- thelial cells,club cells,and goblet mucous cells lining the gill arch and gill filament epithelium. However,in time,no reaction of any of the lipid moieties could be observed,indicating the absence of the same,using various histochemical techniques.The results are discussed in light of the mechanistic understanding of detergent action.1989 Academic Press,Inc.
基金This project was financially supported by the National Natural Science Foundation of China(Grant No.50279027)
文摘Sliding is one of the principal failure types of caisson breakwaters and is an essential content of stability examination in caisson breakwater design. Herein, the mass-spring-dashpot model of caisson-base system is used to simulate the vibrating-sliding motion of the caisson under various types of breaking wave impact forces, i.e., single peak impact force, double peak impact force, and shock-damping oscillation impact force. The effects of various breaking wave impacts and the sliding motion on the dynamic response behaviors of caisson breakwaters are investigated and the calculation of relevant system parameters is discussed. It is shown that the dynamic responses of the caisson are significantly different under different types of breaking wave impact forces even when the amplitudes of impact forces are equal. The amplitude of dynamic response of the caisson is lower under single peak impact excitation than that under double peak impact or shock-damping oscillation impact excitation. Though the displacement of the caisson is large due to sliding, the rotation, the sliding force and the overturning moment of the caisson are significantly reduced.
基金supported by the National Natural Science Foundation of China(No.82271889,82572117,82371173,82172105)the National Key Research and Development Program of China(No.2021YFC2701000)Shanghai Natural Science Foundation(23ZR1409400,24ZR1409400)。
文摘Craniofacial development relies on the migration of cranial neural crest cells(CNCCs)to the first and second pharyngeal arches,followed by their differentiation into various cell types during embryogenesis.Although the CNCC migration has been well-studied,the role of the niche in relation to CNCC remains unclear.Variants in FOXI3 have been implicated in craniofacial microsomia(CFM),yet the molecular mechanisms remain unexplored.FOXI3 is expressed in the ectoderm and auricle epidermis,but not in CNCCs or cartilage.Deletion of Foxi3 in the mouse CNCCs did not disrupt mandible and auricular development,further confirming that FOXI3 does not directly regulate CNCCs.However,Foxi3 deficiency in the ectoderm reduced the production of chondrogenesis-related cytokines derived from ectodermal cells,such as TGF-β1.This impairment affected CNCC proliferation through cell communication,subsequently altering the development of the mandible and auricle.These results emphasize the critical role of FOXI3 in establishing the microenvironment supporting CNCC function.Furthermore,FOXI3 directly regulates target genes associated with translation,thereby orchestrating cytokine production in epidermal cells.The validation using auricle sample from a CFM patient carrying FOXI3 mutation further supports our findings.These insights highlight the function of FOXI3 in creating the niche necessary for CNCC development and provide a basis for understanding the molecular mechanisms driving CFM pathogenesis.
文摘Generally Fibonacci series and Lucas series are the same, they converge to golden ratio. After I read Fibonacci series, I thought, is there or are there any series which converges to golden ratio. Because of that I explored the inter relations of Fibonacci series when I was intent on Fibonacci series in my difference parallelogram. In which, I found there is no degeneration on Fibonacci series. In my thought, Pascal triangle seemed like a lower triangular matrix, so I tried to find the inverse for that. In inverse form, there is no change against original form of Pascal elements matrix. One day I played with ring magnets, which forms hexagonal shapes. Number of rings which forms Hexagonal shape gives Hex series. In this paper, I give the general formula for generating various types of Fibonacci series and its non-degeneration, how Pascal elements maintain its identities and which shapes formed by hex numbers by difference and matrices.
