Between 2016 and 2024,the Chinese government incorporated several innovative drugs into the National Reimbursement Drug List(NRDL)through price negotiations.These negotiations led to significant price reductions,which...Between 2016 and 2024,the Chinese government incorporated several innovative drugs into the National Reimbursement Drug List(NRDL)through price negotiations.These negotiations led to significant price reductions,which in turn stimulated an increase in sales.This study aimed to assess the impact of this policy on the pricing,utilization,and overall expenditure of targeted lung cancer therapies included in the NRDL.Using an interrupted time series analysis of procurement data from 698 healthcare institutions,the study evaluated both immediate and long-term effects.In terms of immediate effects,price negotiations resulted in a significant decline in the defined daily dose cost(DDDc)for all targeted therapies(P<0.05).Regarding long-term trends,a significant shift was observed only in the pricing trajectory of Gefitinib,Icotinib,and Ensartinib(P<0.05).In terms of immediate effects on drug utilization,all targeted medicines experienced a substantial increase in volume(P<0.05),except for Gefitinib and Icotinib.Over the long term,the usage of all targeted therapies exhibited a significant upward trend(P<0.05).With respect to expenditure,the immediate impact of NRDL inclusion resulted in a significant increase in spending on Afatinib,Crizotinib,Osimertinib,Alectinib,and Ensartinib(P<0.05).Over time,total spending on targeted medicines showed a significant increase(P<0.05),except for Erlotinib.Overall,NRDL price negotiations successfully reduced the economic burden on lung cancer patients,improving both accessibility and affordability of targeted therapies in China.展开更多
Accurate short-term electricity price forecasts are essential for market participants to optimize bidding strategies,hedge risk and plan generation schedules.By leveraging advanced data analytics and machine learning ...Accurate short-term electricity price forecasts are essential for market participants to optimize bidding strategies,hedge risk and plan generation schedules.By leveraging advanced data analytics and machine learning methods,accurate and reliable price forecasts can be achieved.This study forecasts day-ahead prices in Türkiye’s electricity market using eXtreme Gradient Boosting(XGBoost).We benchmark XGBoost against four alternatives—Support Vector Machines(SVM),Long Short-Term Memory(LSTM),Random Forest(RF),and Gradient Boosting(GBM)—using 8760 hourly observations from 2023 provided by Energy Exchange Istanbul(EXIST).All models were trained on an identical chronological 80/20 train–test split,with hyperparameters tuned via 5-fold cross-validation on the training set.XGBoost achieved the best performance(Mean Absolute Error(MAE)=144.8 TRY/MWh,Root Mean Square Error(RMSE)=201.8 TRY/MWh,coefficient of determination(R^(2))=0.923)while training in 94 s.To enhance interpretability and identify key drivers,we employed Shapley Additive Explanations(SHAP),which highlighted a strong association between higher prices and increased natural-gas-based generation.The results provide a clear performance benchmark and practical guidance for selecting forecasting approaches in day-ahead electricity markets.展开更多
Accurate forecasting of crude oil futures prices is crucial for understanding global energy market dynamics and formulating effective macroeconomic and energy strategies.However,the strong nonlinearity and multi-scale...Accurate forecasting of crude oil futures prices is crucial for understanding global energy market dynamics and formulating effective macroeconomic and energy strategies.However,the strong nonlinearity and multi-scale temporal characteristics of crude oil prices pose significant challenges to traditional forecasting methods.To address these issues,this study proposes a hybrid CEEMDAN–HOA–Transformer–GRU model that integrates decomposition,complexity analysis,adaptive modeling,and intelligent optimization.Specifically,Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)is employed to decompose the original series into multi-scale components,after which entropy-based complexity analysis quantitatively evaluates each component.A differentiated modeling strategy is then applied:Transformer networks capture long-term dependencies in high-complexity components,while Gated Recurrent Units(GRU)model short-term dynamics in relatively simple components.To further enhance robustness,the Hiking Optimization Algorithm(HOA)is used for joint hyperparameter optimization across both base learners.Empirical analysis of WTI and Brent crude oil futures demonstrates the technical effectiveness of the framework.Compared with benchmark models,the proposed method reduces RMSE by 79.16% for WTI and 77.47% for Brent.Incorporating complexity analysis further decreases RMSE by 36.51%for WTI and 34.93%for Brent,confirming the superior nonlinear modeling capacity and generalization performance of the integrated framework.Overall,this study provides not only a technically reliable tool for modeling complex financial time series but also practical guidance for improving the accuracy and stability of crude oil price forecasting,thereby supporting market monitoring,risk management,and policy formulation.展开更多
This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data e...This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data exchanges transitioning from quasi-public to marketoriented operations.To address the complex dynamics among data exchanges,suppliers,and consumers,the authors develop a threestage Stackelberg game framework.In this model,the data exchange acts as a leader setting transaction commission rates,suppliers are intermediate leaders determining unit prices,and consumers are followers making purchasing decisions.Two pricing strategies are examined:the Independent Pricing Approach(IPA)and the novel Perfectly Competitive Pricing Approach(PCPA),which accounts for competition among data providers.Using backward induction,the study derives subgame-perfect equilibria and proves the existence and uniqueness of Stackelberg equilibria under both approaches.Extensive numerical simulations are carried out in the model,demonstrating that PCPA enhances data demander utility,encourages supplier competition,increases transaction volume,and improves the overall profitability and sustainability of data exchanges.Social welfare analysis further confirms PCPA’s superiority in promoting efficient and fair data markets.展开更多
Due to the centralization of charging stations(CSs),CSs are organized as charging station alliances(CSAs)in the commercial competition.Under this situation,this paper studies the profit-oriented dynamic pricing strate...Due to the centralization of charging stations(CSs),CSs are organized as charging station alliances(CSAs)in the commercial competition.Under this situation,this paper studies the profit-oriented dynamic pricing strategy of CSAs.As the practicability basis,a privacy-protected bidirectional real-time information interaction framework is designed,under which the status of EVs is utilized as the reference for pricing,and the prices of CSs are the reference for charging decisions.Based on this framework,the decision-making models of EVs and CSs are established,in which the uncertainty caused by the information asymmetry between EVs and CSs and the bounded rationality of EV users are integrated.To solve the pricing decision model,the evolutionary game theory is adopted to describe the dynamic pricing game among CSAs,the equilibrium of which gives the optimal pricing strategy.Finally,the case study conducted in an urban area of Shanghai,China,validates the practicability of the framework and the effectiveness of the dynamic pricing strategy.展开更多
The accessibility of urban public transit directly influences residents’quality of life,travel behavior,and social equity.Its correlation with housing prices has garnered significant attention across disciplines such...The accessibility of urban public transit directly influences residents’quality of life,travel behavior,and social equity.Its correlation with housing prices has garnered significant attention across disciplines such as geography,economics,and urban planning.Although much existing research focuses on the impact of individual transportation facilities on housing prices,there is a notable gap in comprehensive analyses that assess the influence of overall urban transit accessibility on housing market dynamics.This study selected the main urban area of Hefei,China,as a case to investigate the spatial distribution of housing prices and evaluate public transit accessibility in 2022.Employing techniques such as the optimized parameter geographical detector and local spatial regression models,the study aimed to elucidate the effects and underlying mechanisms of urban transit accessibility on housing prices.The findings revealed that:1)housing prices in Hefei exhibited a clustered spatial pattern,with high prices concentrated in the city center and lower prices in peripheral areas,forming three distinct high-price hotspots with a‘belt-like’distribution;2)public transit accessibility showed a‘coreperiphery’structure,with accessibility declining in a‘circumferential’pattern around the city center.Based on the‘housing price-accessibility’dimension,four categories were identified:high price-high accessibility(37.25%),high price-low accessibility(19.07%),low price-high accessibility(21.95%),and low price-low accessibility(21.73%);3)the impact of transit accessibility on housing prices was spatially heterogeneous,with bus travel showing the strongest explanatory power(0.692),followed by automobile,subway,and bicycle travel.The interaction of these transportation modes generated a synergistic effect on housing price differentiation,with most influencing factors contributing more than 25%.These findings offer valuable insights for optimizing the spatial distribution of public transit infrastructure and improving both urban housing quality and residents’living standards.展开更多
Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot o...Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot objectively compare biddings: timber trade is a lottery game. Bucking is analyzed in terms of sawlog, pulp wood, log cylinder, sawn wood, value-weighted sawn wood, and chips. Sawn wood and its value are computed from top diameter of the sawlog. Profit maximization requires buyers to buck logs producing smaller than maximal value, causing dead weight loss. Nominal assortment prices have unpredictable relation to effective stumpage price. Assortment pricing does not meet requirements of market economy. If sawmills linked to pulp mills buck smaller sawlog percentages than independent sawmills, as generally believed, they use higher price for chips in their own harvests than they pay for independent sawmills, indicating imperfect competition for chips. Sawn wood potential pricing is suggested which gives prices for sawn wood and chips coming both from sawlogs and pulp wood in reference bucking which maximizes sawn wood for given minimum and maximum log length and minimum top diameter. Simple algorithm generates feasible bucking schedules from which optimum can be selected using any objective. Pricing produces unit price for all commercial wood utilizing ratio of theoretical sawn wood and commercial volume in stand. Unit price can be compared to stem pricing and could be compared to assortment pricing if assortment pricing would produce predictable sawlog percentages. Sawn wood potential pricing is concrete, transparent, easy to compute, considers stem size and tapering, reduces trading cost and is less risky to buyers than stem pricing. It meets requirements of market economy. Readers can repeat computations using open-source software Jlp22.展开更多
On the background of integrated ERP development, activity-value-flexibility management (AVFM) is defined. By using economic-value-added (EVA) and corporate value creation as the objective of AVFM, custom value deviati...On the background of integrated ERP development, activity-value-flexibility management (AVFM) is defined. By using economic-value-added (EVA) and corporate value creation as the objective of AVFM, custom value deviating rate, capital cost deviating rate, cash-flow-out per purchase deviating rate and cash-flow-in per sell deviating rate are developed to be the key responding variates for AVFM, and they also decide the rational quantity range for AVFM tactics. Method for rational AVFM tactics solution could be got by means of redesigning activity information process on integrated ERP.展开更多
Test Case Prioritization(TCP)techniques perform better than other regression test optimization techniques including Test Suite Reduction(TSR)and Test Case Selection(TCS).Many TCP techniques are available,and their per...Test Case Prioritization(TCP)techniques perform better than other regression test optimization techniques including Test Suite Reduction(TSR)and Test Case Selection(TCS).Many TCP techniques are available,and their performance is usually measured through a metric Average Percentage of Fault Detection(APFD).This metric is value-neutral because it only works well when all test cases have the same cost,and all faults have the same severity.Using APFD for performance evaluation of test case orders where test cases cost or faults severity varies is prone to produce false results.Therefore,using the right metric for performance evaluation of TCP techniques is very important to get reliable and correct results.In this paper,two value-based TCP techniques have been introduced using Genetic Algorithm(GA)including Value-Cognizant Fault Detection-Based TCP(VCFDB-TCP)and Value-Cognizant Requirements Coverage-Based TCP(VCRCB-TCP).Two novel value-based performance evaluation metrics are also introduced for value-based TCP including Average Percentage of Fault Detection per value(APFDv)and Average Percentage of Requirements Coverage per value(APRCv).Two case studies are performed to validate proposed techniques and performance evaluation metrics.The proposed GA-based techniques outperformed the existing state-of-the-art TCP techniques including Original Order(OO),Reverse Order(REV-O),Random Order(RO),and Greedy algorithm.展开更多
In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy sys...In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load aggregator.Owing to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption power.The price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption power.Mutual benefits and win-win situations are achieved between the upper and lower multistakeholders.Finally,CPLEX is used to iteratively solve the bilevel optimization model.The optimal solution is selected according to the joint optimal discrimination mechanism.Thesimulation results indicate that the sourceload coordinate operation can reduce the upper and lower operation costs.Using the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.展开更多
Investors should always argue about management fees because of their impact on net performance that can be substantial.This especially for investments,like real estate,which require intensive management.However,differ...Investors should always argue about management fees because of their impact on net performance that can be substantial.This especially for investments,like real estate,which require intensive management.However,different from traditional mutual funds that are usually related to the gross value of the assets under management,but similar to other financial industry sectors(e.g.hedge funds and private equity funds),REIT managers’compensation structure typically provides a basically fixed payment based alternatively on gross asset value(GAV)or net asset value(NAV).In addition,managers usually also gain a performance fee.The paper analyses how the two alternative compensation schemes influence REITs’investment decisions and capital structure and,consequently,REITs’share value and performance.The final issue addressed is whether—and under which conditions—one compensation scheme is superior to the other.Due to the(usual)market price discount on NAVs,both fee structures incentivise managers to leverage—even in a tax-free environment—in order to maximize the management fees.However,the leverage motivation is stronger for GAV-based than for NAV-based REITs,which are also expected to be more selective in investment decisions.Overall,considering initial fee percentage,GAV-based REITs are expected to execute higher management fees than NAV-based REITs due to the relevant leverage effect.Moreover,debt recourse produces different effects on share value if measured upon market price or net asset value.The empirical analysis focuses on public Italian REITs(2002-2012).The results seem to support the theoretical expectations.GAV-based REITs experience higher debt trends and levels than NAV-based REITs.At the same time,GAV-based REITs register lower real estate asset returns gross and net of management fees for both current and growth yields.Differences in the returns lead to permanent higher performances over total return indexes of NAV-based REITs compared to GAV-based REITs.展开更多
Objective To evaluate the effect of pharmacist-driven antimicrobial stewardship based on value-based healthcare in a tertiary hospital in China.Methods The application of plan-do-check-action(PDCA)cycle and antimicrob...Objective To evaluate the effect of pharmacist-driven antimicrobial stewardship based on value-based healthcare in a tertiary hospital in China.Methods The application of plan-do-check-action(PDCA)cycle and antimicrobial stewardship(AMS)were respectively used to improve the rational use of antimicrobial agents in prophylactic and therapeutic.Data were collected and the effect was assessed during the management period(2016-2019).Results and Conclusion From 2016(before implementation)to 2019(after implementation),the rational use of antibiotics were obviously enhanced in outpatients,inpatients,and emergency department.For instance,the utilization rate in type I incision operation was decreased from 26.42%to 14.60%(P=0.000),the daily doses of antibiotic per 100 patient-days decreased from 49.34±2.97 to 35.89±4.96(P=0.000),and the average antibiotic expenditures dropped from 948.53 yuan to 526.30 yuan(P=0.000).There was no significant change in infection rate,nosocomial mortality rate,and the length of hospital stay.After the implementation of clinical pharmacist-driven antimicrobial stewardship based on value-based healthcare,the consumption and cost of antibacterial have been greatly reduced.Therefore,the pharmacist-driven antimicrobial stewardship increases its value。展开更多
The basic framework of price policies for promoting renewable power de- velopment in China is introduced. The background, concept and implementation of price policies, focused on wind power, biomass power and solar po...The basic framework of price policies for promoting renewable power de- velopment in China is introduced. The background, concept and implementation of price policies, focused on wind power, biomass power and solar power, are summarized in the article. The experiences and lessons of implementation of these price policies are analyzed. It is concluded that reasonable price policy is quite effective for promoting re- newable power development. According to the requirement of China's renewable power development, the suggestions for improving renewable power pricing mechanism and price incentive policies are proposed.展开更多
In essence,the negotiation of license fees on standard essential patent(SEP)belongs to a kind of market be⁃havior,and the pricing right should be given to the market subjects under the requirements of patent law.In re...In essence,the negotiation of license fees on standard essential patent(SEP)belongs to a kind of market be⁃havior,and the pricing right should be given to the market subjects under the requirements of patent law.In recent years,the frequent disputes on SEP license fees witnessed in the industrial and academic worlds,together with the lack of systematic supporting functions like FRAND,make SEP pricing excessively reliant on judicial judgment in practice.Fortunately,a variety of pricing methods have been proposed by theoretical research and practiced in judicial cases,which provide possible solutions for the license fee pricing of SEP from the operational level.In this paper,by focusing on the characteristics of the existing SEP pricing methods in the academic fields and judicial system,the dispute caused by license fees of SEP is clarified firstly,then by combining and interpreting twelve existing pricing methods of license fee of SEP with academic literature and judicial cases,four categories of methods are composed based on the application stages and calculation logic.Thirdly,the application barriers and dilemmas caused by the inherent limita⁃tions of the four categories of methods are analyzed,and the possible ways to put these methods into practice are ex⁃plored.Lastly,suggestions are presented from the aspects of preconditions for application,pricing stages,dispute reso⁃lution mechanisms,and comprehensive applications.The purpose of this paper is to provide enlightenment for getting back on track with the pricing right and further optimization of the pricing mechanism of license fees of SEP.展开更多
Understanding how renewable energy generation affects electricity prices is essential for designing efficient and sustainable electricity markets.However,most existing studies rely on regression-based approaches that ...Understanding how renewable energy generation affects electricity prices is essential for designing efficient and sustainable electricity markets.However,most existing studies rely on regression-based approaches that capture correlations but fail to identify causal relationships,particularly in the presence of non-linearities and confounding factors.This limits their value for informing policy and market design in the context of the energy transition.To address this gap,we propose a novel causal inference framework based on local partially linear double machine learning(DML).Our method isolates the true impact of predicted wind and solar power generation on electricity prices by controlling for high-dimensional confounders and allowing for non-linear,context-dependent effects.This represents a substantial methodological advancement over standard econometric techniques.Applying this framework to the UK electricity market over the period 2018-2024,we produce the first robust causal estimates of how renewables affect dayahead wholesale electricity prices.We find that wind power exerts a U-shaped causal effect:at low penetration levels,a 1 GWh increase reduces prices by up to£7/MWh,the effect weakens at mid-levels,and intensifies again at higher penetration.Solar power consistently reduces prices at low penetration levels,up to£9/MWh per additional GWh,but its marginal effect diminishes quickly.Importantly,the magnitude of these effects has increased over time,reflecting the growing influence of renewables on price formation as their share in the energy mix rises.These findings offer a sound empirical basis for improving the design of support schemes,refining capacity planning,and enhancing electricity market efficiency.By providing a robust causal understanding of renewable impacts,our study contributes both methodological innovation and actionable insights to guide future energy policy.展开更多
Stock price prediction is a typical complex time series prediction problem characterized by dynamics,nonlinearity,and complexity.This paper introduces a generative adversarial network model that incorporates an attent...Stock price prediction is a typical complex time series prediction problem characterized by dynamics,nonlinearity,and complexity.This paper introduces a generative adversarial network model that incorporates an attention mechanism(GAN-LSTM-Attention)to improve the accuracy of stock price prediction.Firstly,the generator of this model combines the Long and Short-Term Memory Network(LSTM),the Attention Mechanism and,the Fully-Connected Layer,focusing on generating the predicted stock price.The discriminator combines the Convolutional Neural Network(CNN)and the Fully-Connected Layer to discriminate between real stock prices and generated stock prices.Secondly,to evaluate the practical application ability and generalization ability of the GAN-LSTM-Attention model,four representative stocks in the United States of America(USA)stock market,namely,Standard&Poor’s 500 Index stock,Apple Incorporatedstock,AdvancedMicroDevices Incorporatedstock,and Google Incorporated stock were selected for prediction experiments,and the prediction performance was comprehensively evaluated by using the three evaluation metrics,namely,mean absolute error(MAE),root mean square error(RMSE),and coefficient of determination(R2).Finally,the specific effects of the attention mechanism,convolutional layer,and fully-connected layer on the prediction performance of the model are systematically analyzed through ablation study.The results of experiment show that the GAN-LSTM-Attention model exhibits excellent performance and robustness in stock price prediction.展开更多
At the beginning of 2025,China’s national carbon market carbon price trend exhibited a continuous unilateral downward trajectory,representing a departure from the overall steady upward trend in carbon prices since th...At the beginning of 2025,China’s national carbon market carbon price trend exhibited a continuous unilateral downward trajectory,representing a departure from the overall steady upward trend in carbon prices since the carbon market launched in 2021.The analysis suggests that the primary reason for the recent decline in carbon prices is the reversal of supply and demand dynamics in the carbon market,with increased quota supply amid a sluggish economy.It is expected that downward pressure on carbon prices will persist in the short term,but with more industries being included and continued policy optimization and improvement,a rise in China’s medium-to long-term carbon prices is highly probable.Recommendations for enterprises involved in carbon asset operations and management:first,refining carbon asset reserves and trading strategies;second,accelerating internal CCER project development;third,exploring carbon financial instrument applications;fourth,establishing and improving internal carbon pricing mechanisms;fifth,proactively planning for new industry inclusion.展开更多
Nodal pricing is a critical mechanism in electricity markets,utilized to determine the cost of power transmission to various nodes within a distribution network.As power systems evolve to incorporate higher levels of ...Nodal pricing is a critical mechanism in electricity markets,utilized to determine the cost of power transmission to various nodes within a distribution network.As power systems evolve to incorporate higher levels of renewable energy and face increasing demand fluctuations,traditional nodal pricing models often fall short to meet these new challenges.This research introduces a novel enhanced nodal pricing mechanism for distribution networks,integrating advanced optimization techniques and hybrid models to overcome these limitations.The primary objective is to develop a model that not only improves pricing accuracy but also enhances operational efficiency and system reliability.This study leverages cutting-edge hybrid algorithms,combining elements of machine learning with conventional optimization methods,to achieve superior performance.Key findings demonstrate that the proposed hybrid nodal pricing model significantly reduces pricing errors and operational costs compared to conventional methods.Through extensive simulations and comparative analysis,the model exhibits enhanced performance under varying load conditions and increased levels of renewable energy integration.The results indicate a substantial improvement in pricing precision and network stability.This study contributes to the ongoing discourse on optimizing electricity market mechanisms and provides actionable insights for policymakers and utility operators.By addressing the complexities of modern power distribution systems,our research offers a robust solution that enhances the efficiency and reliability of power distribution networks,marking a significant advancement in the field.展开更多
The nonlinearity of hedonic datasets demands flexible automated valuation models to appraise housing prices accurately,and artificial intelligence models have been employed in mass appraisal to this end.However,they h...The nonlinearity of hedonic datasets demands flexible automated valuation models to appraise housing prices accurately,and artificial intelligence models have been employed in mass appraisal to this end.However,they have been referred to as“blackbox”models owing to difficulties associated with interpretation.In this study,we compared the results of traditional hedonic pricing models with those of machine learning algorithms,e.g.,random forest and deep neural network models.Commonly implemented measures,e.g.,Gini importance and permutation importance,provide only the magnitude of each explanatory variable’s importance,which results in ambiguous interpretability.To address this issue,we employed the SHapley Additive exPlanation(SHAP)method and explored its effectiveness through comparisons with traditionally explainable measures in hedonic pricing models.The results demonstrated that(1)the random forest model with the SHAP method could be a reliable instrument for appraising housing prices with high accuracy and sufficient interpretability,(2)the interpretable results retrieved from the SHAP method can be consolidated by the support of statistical evidence,and(3)housing characteristics and local amenities are primary contributors in property valuation,which is consistent with the findings of previous studies.Thus,our novel methodological framework and robust findings provide informative insights into the use of machine learning methods in property valuation based on the comparative analysis.展开更多
基金Research on Innovative Method of Drug Rational Use Supervision Decision Based on Big Data of Medical Insurance(Grant No.82273899)。
文摘Between 2016 and 2024,the Chinese government incorporated several innovative drugs into the National Reimbursement Drug List(NRDL)through price negotiations.These negotiations led to significant price reductions,which in turn stimulated an increase in sales.This study aimed to assess the impact of this policy on the pricing,utilization,and overall expenditure of targeted lung cancer therapies included in the NRDL.Using an interrupted time series analysis of procurement data from 698 healthcare institutions,the study evaluated both immediate and long-term effects.In terms of immediate effects,price negotiations resulted in a significant decline in the defined daily dose cost(DDDc)for all targeted therapies(P<0.05).Regarding long-term trends,a significant shift was observed only in the pricing trajectory of Gefitinib,Icotinib,and Ensartinib(P<0.05).In terms of immediate effects on drug utilization,all targeted medicines experienced a substantial increase in volume(P<0.05),except for Gefitinib and Icotinib.Over the long term,the usage of all targeted therapies exhibited a significant upward trend(P<0.05).With respect to expenditure,the immediate impact of NRDL inclusion resulted in a significant increase in spending on Afatinib,Crizotinib,Osimertinib,Alectinib,and Ensartinib(P<0.05).Over time,total spending on targeted medicines showed a significant increase(P<0.05),except for Erlotinib.Overall,NRDL price negotiations successfully reduced the economic burden on lung cancer patients,improving both accessibility and affordability of targeted therapies in China.
文摘Accurate short-term electricity price forecasts are essential for market participants to optimize bidding strategies,hedge risk and plan generation schedules.By leveraging advanced data analytics and machine learning methods,accurate and reliable price forecasts can be achieved.This study forecasts day-ahead prices in Türkiye’s electricity market using eXtreme Gradient Boosting(XGBoost).We benchmark XGBoost against four alternatives—Support Vector Machines(SVM),Long Short-Term Memory(LSTM),Random Forest(RF),and Gradient Boosting(GBM)—using 8760 hourly observations from 2023 provided by Energy Exchange Istanbul(EXIST).All models were trained on an identical chronological 80/20 train–test split,with hyperparameters tuned via 5-fold cross-validation on the training set.XGBoost achieved the best performance(Mean Absolute Error(MAE)=144.8 TRY/MWh,Root Mean Square Error(RMSE)=201.8 TRY/MWh,coefficient of determination(R^(2))=0.923)while training in 94 s.To enhance interpretability and identify key drivers,we employed Shapley Additive Explanations(SHAP),which highlighted a strong association between higher prices and increased natural-gas-based generation.The results provide a clear performance benchmark and practical guidance for selecting forecasting approaches in day-ahead electricity markets.
基金funded by the Henan Provincial Natural Science Foundation(grant no.242300421257).
文摘Accurate forecasting of crude oil futures prices is crucial for understanding global energy market dynamics and formulating effective macroeconomic and energy strategies.However,the strong nonlinearity and multi-scale temporal characteristics of crude oil prices pose significant challenges to traditional forecasting methods.To address these issues,this study proposes a hybrid CEEMDAN–HOA–Transformer–GRU model that integrates decomposition,complexity analysis,adaptive modeling,and intelligent optimization.Specifically,Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)is employed to decompose the original series into multi-scale components,after which entropy-based complexity analysis quantitatively evaluates each component.A differentiated modeling strategy is then applied:Transformer networks capture long-term dependencies in high-complexity components,while Gated Recurrent Units(GRU)model short-term dynamics in relatively simple components.To further enhance robustness,the Hiking Optimization Algorithm(HOA)is used for joint hyperparameter optimization across both base learners.Empirical analysis of WTI and Brent crude oil futures demonstrates the technical effectiveness of the framework.Compared with benchmark models,the proposed method reduces RMSE by 79.16% for WTI and 77.47% for Brent.Incorporating complexity analysis further decreases RMSE by 36.51%for WTI and 34.93%for Brent,confirming the superior nonlinear modeling capacity and generalization performance of the integrated framework.Overall,this study provides not only a technically reliable tool for modeling complex financial time series but also practical guidance for improving the accuracy and stability of crude oil price forecasting,thereby supporting market monitoring,risk management,and policy formulation.
基金supported by the National Natural Science Foundation of China[grant numbers 12171158,12371474 and 12571510]Fundamental Research Funds for the Central Universities[grant number 2025ECNU-WLJC006].
文摘This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data exchanges transitioning from quasi-public to marketoriented operations.To address the complex dynamics among data exchanges,suppliers,and consumers,the authors develop a threestage Stackelberg game framework.In this model,the data exchange acts as a leader setting transaction commission rates,suppliers are intermediate leaders determining unit prices,and consumers are followers making purchasing decisions.Two pricing strategies are examined:the Independent Pricing Approach(IPA)and the novel Perfectly Competitive Pricing Approach(PCPA),which accounts for competition among data providers.Using backward induction,the study derives subgame-perfect equilibria and proves the existence and uniqueness of Stackelberg equilibria under both approaches.Extensive numerical simulations are carried out in the model,demonstrating that PCPA enhances data demander utility,encourages supplier competition,increases transaction volume,and improves the overall profitability and sustainability of data exchanges.Social welfare analysis further confirms PCPA’s superiority in promoting efficient and fair data markets.
基金sponsored in part by the National Natural Science Foundation of China(52167014)in part by the Science and Technology Commission of Shanghai Municipality(23XD1422000,23QB1400500).
文摘Due to the centralization of charging stations(CSs),CSs are organized as charging station alliances(CSAs)in the commercial competition.Under this situation,this paper studies the profit-oriented dynamic pricing strategy of CSAs.As the practicability basis,a privacy-protected bidirectional real-time information interaction framework is designed,under which the status of EVs is utilized as the reference for pricing,and the prices of CSs are the reference for charging decisions.Based on this framework,the decision-making models of EVs and CSs are established,in which the uncertainty caused by the information asymmetry between EVs and CSs and the bounded rationality of EV users are integrated.To solve the pricing decision model,the evolutionary game theory is adopted to describe the dynamic pricing game among CSAs,the equilibrium of which gives the optimal pricing strategy.Finally,the case study conducted in an urban area of Shanghai,China,validates the practicability of the framework and the effectiveness of the dynamic pricing strategy.
基金Under the auspices of the National Natural Science Foundation of China(No.42271224,41901193)Ministry of Edu cation Humanities and Social Sciences Research Planning Fund Project of China(No.24YJAZH190)+1 种基金Anhui Province Excellent Youth Research Project in Universities(No.2022AH030019)Anhui Social Sciences Innovation Development Research Project(No.2024CXQ503)。
文摘The accessibility of urban public transit directly influences residents’quality of life,travel behavior,and social equity.Its correlation with housing prices has garnered significant attention across disciplines such as geography,economics,and urban planning.Although much existing research focuses on the impact of individual transportation facilities on housing prices,there is a notable gap in comprehensive analyses that assess the influence of overall urban transit accessibility on housing market dynamics.This study selected the main urban area of Hefei,China,as a case to investigate the spatial distribution of housing prices and evaluate public transit accessibility in 2022.Employing techniques such as the optimized parameter geographical detector and local spatial regression models,the study aimed to elucidate the effects and underlying mechanisms of urban transit accessibility on housing prices.The findings revealed that:1)housing prices in Hefei exhibited a clustered spatial pattern,with high prices concentrated in the city center and lower prices in peripheral areas,forming three distinct high-price hotspots with a‘belt-like’distribution;2)public transit accessibility showed a‘coreperiphery’structure,with accessibility declining in a‘circumferential’pattern around the city center.Based on the‘housing price-accessibility’dimension,four categories were identified:high price-high accessibility(37.25%),high price-low accessibility(19.07%),low price-high accessibility(21.95%),and low price-low accessibility(21.73%);3)the impact of transit accessibility on housing prices was spatially heterogeneous,with bus travel showing the strongest explanatory power(0.692),followed by automobile,subway,and bicycle travel.The interaction of these transportation modes generated a synergistic effect on housing price differentiation,with most influencing factors contributing more than 25%.These findings offer valuable insights for optimizing the spatial distribution of public transit infrastructure and improving both urban housing quality and residents’living standards.
文摘Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot objectively compare biddings: timber trade is a lottery game. Bucking is analyzed in terms of sawlog, pulp wood, log cylinder, sawn wood, value-weighted sawn wood, and chips. Sawn wood and its value are computed from top diameter of the sawlog. Profit maximization requires buyers to buck logs producing smaller than maximal value, causing dead weight loss. Nominal assortment prices have unpredictable relation to effective stumpage price. Assortment pricing does not meet requirements of market economy. If sawmills linked to pulp mills buck smaller sawlog percentages than independent sawmills, as generally believed, they use higher price for chips in their own harvests than they pay for independent sawmills, indicating imperfect competition for chips. Sawn wood potential pricing is suggested which gives prices for sawn wood and chips coming both from sawlogs and pulp wood in reference bucking which maximizes sawn wood for given minimum and maximum log length and minimum top diameter. Simple algorithm generates feasible bucking schedules from which optimum can be selected using any objective. Pricing produces unit price for all commercial wood utilizing ratio of theoretical sawn wood and commercial volume in stand. Unit price can be compared to stem pricing and could be compared to assortment pricing if assortment pricing would produce predictable sawlog percentages. Sawn wood potential pricing is concrete, transparent, easy to compute, considers stem size and tapering, reduces trading cost and is less risky to buyers than stem pricing. It meets requirements of market economy. Readers can repeat computations using open-source software Jlp22.
基金Supported by the National Natural Science Foundation of China (No. 70031020)
文摘On the background of integrated ERP development, activity-value-flexibility management (AVFM) is defined. By using economic-value-added (EVA) and corporate value creation as the objective of AVFM, custom value deviating rate, capital cost deviating rate, cash-flow-out per purchase deviating rate and cash-flow-in per sell deviating rate are developed to be the key responding variates for AVFM, and they also decide the rational quantity range for AVFM tactics. Method for rational AVFM tactics solution could be got by means of redesigning activity information process on integrated ERP.
文摘Test Case Prioritization(TCP)techniques perform better than other regression test optimization techniques including Test Suite Reduction(TSR)and Test Case Selection(TCS).Many TCP techniques are available,and their performance is usually measured through a metric Average Percentage of Fault Detection(APFD).This metric is value-neutral because it only works well when all test cases have the same cost,and all faults have the same severity.Using APFD for performance evaluation of test case orders where test cases cost or faults severity varies is prone to produce false results.Therefore,using the right metric for performance evaluation of TCP techniques is very important to get reliable and correct results.In this paper,two value-based TCP techniques have been introduced using Genetic Algorithm(GA)including Value-Cognizant Fault Detection-Based TCP(VCFDB-TCP)and Value-Cognizant Requirements Coverage-Based TCP(VCRCB-TCP).Two novel value-based performance evaluation metrics are also introduced for value-based TCP including Average Percentage of Fault Detection per value(APFDv)and Average Percentage of Requirements Coverage per value(APRCv).Two case studies are performed to validate proposed techniques and performance evaluation metrics.The proposed GA-based techniques outperformed the existing state-of-the-art TCP techniques including Original Order(OO),Reverse Order(REV-O),Random Order(RO),and Greedy algorithm.
基金supported by the Central Government Guides Local Science and Technology Development Fund Project(2023ZY0020)Key R&D and Achievement Transformation Project in InnerMongolia Autonomous Region(2022YFHH0019)+3 种基金the Fundamental Research Funds for Inner Mongolia University of Science&Technology(2022053)Natural Science Foundation of Inner Mongolia(2022LHQN05002)National Natural Science Foundation of China(52067018)Metallurgical Engineering First-Class Discipline Construction Project in Inner Mongolia University of Science and Technology,Control Science and Engineering Quality Improvement and Cultivation Discipline Project in Inner Mongolia University of Science and Technology。
文摘In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load aggregator.Owing to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption power.The price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption power.Mutual benefits and win-win situations are achieved between the upper and lower multistakeholders.Finally,CPLEX is used to iteratively solve the bilevel optimization model.The optimal solution is selected according to the joint optimal discrimination mechanism.Thesimulation results indicate that the sourceload coordinate operation can reduce the upper and lower operation costs.Using the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.
文摘Investors should always argue about management fees because of their impact on net performance that can be substantial.This especially for investments,like real estate,which require intensive management.However,different from traditional mutual funds that are usually related to the gross value of the assets under management,but similar to other financial industry sectors(e.g.hedge funds and private equity funds),REIT managers’compensation structure typically provides a basically fixed payment based alternatively on gross asset value(GAV)or net asset value(NAV).In addition,managers usually also gain a performance fee.The paper analyses how the two alternative compensation schemes influence REITs’investment decisions and capital structure and,consequently,REITs’share value and performance.The final issue addressed is whether—and under which conditions—one compensation scheme is superior to the other.Due to the(usual)market price discount on NAVs,both fee structures incentivise managers to leverage—even in a tax-free environment—in order to maximize the management fees.However,the leverage motivation is stronger for GAV-based than for NAV-based REITs,which are also expected to be more selective in investment decisions.Overall,considering initial fee percentage,GAV-based REITs are expected to execute higher management fees than NAV-based REITs due to the relevant leverage effect.Moreover,debt recourse produces different effects on share value if measured upon market price or net asset value.The empirical analysis focuses on public Italian REITs(2002-2012).The results seem to support the theoretical expectations.GAV-based REITs experience higher debt trends and levels than NAV-based REITs.At the same time,GAV-based REITs register lower real estate asset returns gross and net of management fees for both current and growth yields.Differences in the returns lead to permanent higher performances over total return indexes of NAV-based REITs compared to GAV-based REITs.
基金the project:the Science and Technology Planning Project of Zhuhai City of China(No.20191206F060001)。
文摘Objective To evaluate the effect of pharmacist-driven antimicrobial stewardship based on value-based healthcare in a tertiary hospital in China.Methods The application of plan-do-check-action(PDCA)cycle and antimicrobial stewardship(AMS)were respectively used to improve the rational use of antimicrobial agents in prophylactic and therapeutic.Data were collected and the effect was assessed during the management period(2016-2019).Results and Conclusion From 2016(before implementation)to 2019(after implementation),the rational use of antibiotics were obviously enhanced in outpatients,inpatients,and emergency department.For instance,the utilization rate in type I incision operation was decreased from 26.42%to 14.60%(P=0.000),the daily doses of antibiotic per 100 patient-days decreased from 49.34±2.97 to 35.89±4.96(P=0.000),and the average antibiotic expenditures dropped from 948.53 yuan to 526.30 yuan(P=0.000).There was no significant change in infection rate,nosocomial mortality rate,and the length of hospital stay.After the implementation of clinical pharmacist-driven antimicrobial stewardship based on value-based healthcare,the consumption and cost of antibacterial have been greatly reduced.Therefore,the pharmacist-driven antimicrobial stewardship increases its value。
文摘The basic framework of price policies for promoting renewable power de- velopment in China is introduced. The background, concept and implementation of price policies, focused on wind power, biomass power and solar power, are summarized in the article. The experiences and lessons of implementation of these price policies are analyzed. It is concluded that reasonable price policy is quite effective for promoting re- newable power development. According to the requirement of China's renewable power development, the suggestions for improving renewable power pricing mechanism and price incentive policies are proposed.
基金Hierarchical Identification and Cross-Layer Correlation of Key Core Technologies from the Perspective of Industrial Chain Structure (National Social Science Fund of China, 24BTQ067)Chongqing Education Commission (CEC) Funding:Research on the Co-governance Mechanism of Patent Quality Based on the Dual-Filter Perspective(24SKGH213)Chongqing Graduate Education and Teaching Funding:Research on the Interdisciplinary Law of Intellectual Property and Optimization of Graduate Talent Training Mode(yjg213122)。
文摘In essence,the negotiation of license fees on standard essential patent(SEP)belongs to a kind of market be⁃havior,and the pricing right should be given to the market subjects under the requirements of patent law.In recent years,the frequent disputes on SEP license fees witnessed in the industrial and academic worlds,together with the lack of systematic supporting functions like FRAND,make SEP pricing excessively reliant on judicial judgment in practice.Fortunately,a variety of pricing methods have been proposed by theoretical research and practiced in judicial cases,which provide possible solutions for the license fee pricing of SEP from the operational level.In this paper,by focusing on the characteristics of the existing SEP pricing methods in the academic fields and judicial system,the dispute caused by license fees of SEP is clarified firstly,then by combining and interpreting twelve existing pricing methods of license fee of SEP with academic literature and judicial cases,four categories of methods are composed based on the application stages and calculation logic.Thirdly,the application barriers and dilemmas caused by the inherent limita⁃tions of the four categories of methods are analyzed,and the possible ways to put these methods into practice are ex⁃plored.Lastly,suggestions are presented from the aspects of preconditions for application,pricing stages,dispute reso⁃lution mechanisms,and comprehensive applications.The purpose of this paper is to provide enlightenment for getting back on track with the pricing right and further optimization of the pricing mechanism of license fees of SEP.
文摘Understanding how renewable energy generation affects electricity prices is essential for designing efficient and sustainable electricity markets.However,most existing studies rely on regression-based approaches that capture correlations but fail to identify causal relationships,particularly in the presence of non-linearities and confounding factors.This limits their value for informing policy and market design in the context of the energy transition.To address this gap,we propose a novel causal inference framework based on local partially linear double machine learning(DML).Our method isolates the true impact of predicted wind and solar power generation on electricity prices by controlling for high-dimensional confounders and allowing for non-linear,context-dependent effects.This represents a substantial methodological advancement over standard econometric techniques.Applying this framework to the UK electricity market over the period 2018-2024,we produce the first robust causal estimates of how renewables affect dayahead wholesale electricity prices.We find that wind power exerts a U-shaped causal effect:at low penetration levels,a 1 GWh increase reduces prices by up to£7/MWh,the effect weakens at mid-levels,and intensifies again at higher penetration.Solar power consistently reduces prices at low penetration levels,up to£9/MWh per additional GWh,but its marginal effect diminishes quickly.Importantly,the magnitude of these effects has increased over time,reflecting the growing influence of renewables on price formation as their share in the energy mix rises.These findings offer a sound empirical basis for improving the design of support schemes,refining capacity planning,and enhancing electricity market efficiency.By providing a robust causal understanding of renewable impacts,our study contributes both methodological innovation and actionable insights to guide future energy policy.
基金funded by the project supported by the Natural Science Foundation of Heilongjiang Provincial(Grant Number LH2023F033)the Science and Technology Innovation Talent Project of Harbin(Grant Number 2022CXRCCG006).
文摘Stock price prediction is a typical complex time series prediction problem characterized by dynamics,nonlinearity,and complexity.This paper introduces a generative adversarial network model that incorporates an attention mechanism(GAN-LSTM-Attention)to improve the accuracy of stock price prediction.Firstly,the generator of this model combines the Long and Short-Term Memory Network(LSTM),the Attention Mechanism and,the Fully-Connected Layer,focusing on generating the predicted stock price.The discriminator combines the Convolutional Neural Network(CNN)and the Fully-Connected Layer to discriminate between real stock prices and generated stock prices.Secondly,to evaluate the practical application ability and generalization ability of the GAN-LSTM-Attention model,four representative stocks in the United States of America(USA)stock market,namely,Standard&Poor’s 500 Index stock,Apple Incorporatedstock,AdvancedMicroDevices Incorporatedstock,and Google Incorporated stock were selected for prediction experiments,and the prediction performance was comprehensively evaluated by using the three evaluation metrics,namely,mean absolute error(MAE),root mean square error(RMSE),and coefficient of determination(R2).Finally,the specific effects of the attention mechanism,convolutional layer,and fully-connected layer on the prediction performance of the model are systematically analyzed through ablation study.The results of experiment show that the GAN-LSTM-Attention model exhibits excellent performance and robustness in stock price prediction.
文摘At the beginning of 2025,China’s national carbon market carbon price trend exhibited a continuous unilateral downward trajectory,representing a departure from the overall steady upward trend in carbon prices since the carbon market launched in 2021.The analysis suggests that the primary reason for the recent decline in carbon prices is the reversal of supply and demand dynamics in the carbon market,with increased quota supply amid a sluggish economy.It is expected that downward pressure on carbon prices will persist in the short term,but with more industries being included and continued policy optimization and improvement,a rise in China’s medium-to long-term carbon prices is highly probable.Recommendations for enterprises involved in carbon asset operations and management:first,refining carbon asset reserves and trading strategies;second,accelerating internal CCER project development;third,exploring carbon financial instrument applications;fourth,establishing and improving internal carbon pricing mechanisms;fifth,proactively planning for new industry inclusion.
文摘Nodal pricing is a critical mechanism in electricity markets,utilized to determine the cost of power transmission to various nodes within a distribution network.As power systems evolve to incorporate higher levels of renewable energy and face increasing demand fluctuations,traditional nodal pricing models often fall short to meet these new challenges.This research introduces a novel enhanced nodal pricing mechanism for distribution networks,integrating advanced optimization techniques and hybrid models to overcome these limitations.The primary objective is to develop a model that not only improves pricing accuracy but also enhances operational efficiency and system reliability.This study leverages cutting-edge hybrid algorithms,combining elements of machine learning with conventional optimization methods,to achieve superior performance.Key findings demonstrate that the proposed hybrid nodal pricing model significantly reduces pricing errors and operational costs compared to conventional methods.Through extensive simulations and comparative analysis,the model exhibits enhanced performance under varying load conditions and increased levels of renewable energy integration.The results indicate a substantial improvement in pricing precision and network stability.This study contributes to the ongoing discourse on optimizing electricity market mechanisms and provides actionable insights for policymakers and utility operators.By addressing the complexities of modern power distribution systems,our research offers a robust solution that enhances the efficiency and reliability of power distribution networks,marking a significant advancement in the field.
基金supported by the National Research Foundation of Korea grant funded by the Korea government(MSIT)(RS-2025-16067531:Kwangwon Ahn)Hankuk University of Foreign Studies Research Fund(0f 2025:Sihyun An).
文摘The nonlinearity of hedonic datasets demands flexible automated valuation models to appraise housing prices accurately,and artificial intelligence models have been employed in mass appraisal to this end.However,they have been referred to as“blackbox”models owing to difficulties associated with interpretation.In this study,we compared the results of traditional hedonic pricing models with those of machine learning algorithms,e.g.,random forest and deep neural network models.Commonly implemented measures,e.g.,Gini importance and permutation importance,provide only the magnitude of each explanatory variable’s importance,which results in ambiguous interpretability.To address this issue,we employed the SHapley Additive exPlanation(SHAP)method and explored its effectiveness through comparisons with traditionally explainable measures in hedonic pricing models.The results demonstrated that(1)the random forest model with the SHAP method could be a reliable instrument for appraising housing prices with high accuracy and sufficient interpretability,(2)the interpretable results retrieved from the SHAP method can be consolidated by the support of statistical evidence,and(3)housing characteristics and local amenities are primary contributors in property valuation,which is consistent with the findings of previous studies.Thus,our novel methodological framework and robust findings provide informative insights into the use of machine learning methods in property valuation based on the comparative analysis.
