目的:揭示印度藏药材的品种及主治特点,以及与中国同品种的药名和临床应用异同。方法:从印度出版的Materia Medica of Tibetan Medicine和《世界植物速查辞典》《中国民族药辞典》《藏药晶镜本草》《晶珠本草》中提取和发掘印度和中国...目的:揭示印度藏药材的品种及主治特点,以及与中国同品种的药名和临床应用异同。方法:从印度出版的Materia Medica of Tibetan Medicine和《世界植物速查辞典》《中国民族药辞典》《藏药晶镜本草》《晶珠本草》中提取和发掘印度和中国使用的藏药材的信息,包括药材藏文名、梵文名、拉丁学名、药材类型、科属名、性味、药用部位和治疗用途等,建立数据库并进行统计和对比分析。结果:本书共收载568味药材,植物类、动物类、矿物类和其它类药材的占比依次为70.07%、10.92%、6.69%和12.32%,涉及161个科和316个属;中国三本专著中记载的同品种共有158味。记载了药性的药材共有228味,其中同品种药材有50味(药性相似的有25味,不相似的有25味)。记载了药味的药材有296味,其中同品种药材有74味(药味相似的有46味,部分相似的有4味,不相似的有24味)。药材的梵文名与印度撰写的藏语发音相似的有181味药材,不相似的有347味;中国藏语发音和印度撰写的藏语发音相似的有91味,不相似的有66味;三种发音均相似的有13味同品种药材,均不相似的有49味。常用药用部位有动物肉类、果实类、根和根茎类、花类、叶类、树皮类和种子类等,而中国使用同品种的药用部位有一定的差异,主要为果实类、种子类、根类、叶类和树皮类等。多用于治疗消化系统疾病、某些传染病和寄生虫病等,常见主治的症状有便秘、中毒和溃疡等,而中国使用同品种的主治有一定的差异,主要用于消化系统疾病、呼吸系统疾病、皮肤和皮下组织疾病等常见主治的症状有消化不良、腹泻和咳嗽等。结论:印度藏药材的品种较丰富,与中国使用的同品种在药性、药味、药用部位及主治等方面均有差异,有助于扩大藏药材的应用价值,藏药材的发音研究提示其来源和使用交流情况。展开更多
Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesi...Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.展开更多
Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal ...Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.展开更多
The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuli...The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuling Mountain Area from various perspectives, including geographical indication products, geographical indication trademarks, China s geographical indication products mutually recognized and protected with the EU, geographical indication standards, and the exclusive geographical indication logo. It studies the regional public brand characteristics of Chinese authentic medicinal herbs, based on hometown of authentic Chinese medicinal herbs, advantageous regions of characteristic agricultural products, important agricultural cultural heritage, national famous and excellent new agricultural products, national characteristic agricultural products, geographical indication Chinese well-known trademarks, advantageous regions of characteristic agricultural products, and regional public brands of agricultural products. It analyzes the main problems in the protection of geographical indications and the creation of regional public brands, and proposes suggestions for building high-quality authentic medicinal herb bases, developing new quality productivity in the authentic medicinal herb industry, implementing regional brand strategies for authentic medicinal herbs, constructing a new development pattern of dual circulation authentic medicinal herbs, etc.展开更多
Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developme...Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.展开更多
The number of patients with low back pain has increased due to changes in living and working habits.It has become one of the most common diseases in Chinese and Thai clinics.Treatment with Thai traditional medicine ca...The number of patients with low back pain has increased due to changes in living and working habits.It has become one of the most common diseases in Chinese and Thai clinics.Treatment with Thai traditional medicine can effectively alleviate and manage low back pain.This paper aims to summarize the clinical efficacy and distinctive features of Thai traditional medicine(TTM)in managing low back pain.By reviewing recent literature on TTM treatments,including Thai massage,herbal hot massage,and Thai herbal medicine,the paper aims to lay a foundation for TTM treatment in the world and to promote the convergence and development of traditional Chinese and Thai traditional medicine treatment.Additionally,it advocates for the integration and advancement of both Chinese and Thai traditional medical practices,while also encouraging the dissemination of traditional medicine to other countries globally.展开更多
Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、...Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。展开更多
This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the...This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the types,quantities,and shapes of medicinal ingots recorded in Huo Ji Dang(活计档Archives of Imperial Workshops)during the 13-year Yongzheng reign,and by combining these records with existing ingot-related molds,physical specimens,and other collections in the Palace Museum,this research finds that:the Yongzheng Emperor incorporated ingots into the production list of the Imperial Workshop and established standardized preparation procedures,making them a technical practice for displaying imperial power;the fixed system of rewarding ingots during the Dragon Boat Festival turned ingots into a product of Manchu-Han cultural integration and formed a custom;the evolution of ingot equipment was dynamically related to military activities in the mid-Qing dynasty,confirming its function in court politics;and the integration of the preparation and packaging process of ingots into the power operation system,and transforming TCM-related knowledge and technology into means of exercising power,constructed a materialized path for imperial power to regulate the bureaucratic system and social order.The conclusion reveals the inherent logic of the Qing court:establishing authoritative identity through material culture.展开更多
Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelect...Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelectronic devices are now utilized as independent therapeutic interventions or as adjunct treatments,and their applications continue to expand.This article briefly outlines the discovery process of several common electrophysiological signals in the human body and focuses on diverse electrical stimulation technologies.Their applications in the nervous system,cancer treatment,tissue regeneration and repair,and cardiovascular therapy are discussed,along with the underlying mechanisms of action.Furthermore,the rapid development of artificial intelligence and technological innovation has significantly broadened the scope and application of bioelectronic medicine.Finally,the current limitations and future prospects of bioelectronic medicine are explored.展开更多
Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philologica...Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.展开更多
Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for...Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.展开更多
With the advancement of the Belt and Road Initiative and increasing activity in high-altitude regions,the incidence of high-altitude-related diseases has steadily increased.Notably,the prevention and treatment of high...With the advancement of the Belt and Road Initiative and increasing activity in high-altitude regions,the incidence of high-altitude-related diseases has steadily increased.Notably,the prevention and treatment of high-altitude brain injuries remain particularly challenging,making them a key focus of current medical research.The low-pressure and low-oxygen environments at high altitudes significantly increase the risk of hypoxic brain injury.Consequently,understanding the mechanisms that drive these injuries and developing targeted treatments are crucial for maintaining the health of individuals who rapidly ascend to high altitudes.This review examines the mechanisms underlying high-altitude brain injury,outlines the development and evaluation of commonly used animal models for altitude stress,and explores potential therapeutic approaches to support effective prevention and treatment strategies for these conditions.展开更多
This paper divides the centuries-long communication of traditional Chinese medicine(TCM)in France into three progressive stages:the first stage(17th to 19th centuries),characterized by academic recognition and knowled...This paper divides the centuries-long communication of traditional Chinese medicine(TCM)in France into three progressive stages:the first stage(17th to 19th centuries),characterized by academic recognition and knowledge transmission;the second stage(mid-19th century to late 20th century),focusing on clinical verification and school-based innovation;and the third stage(late 20th century to the present),marked by cultural integration and pluralistic coexistence within systems.The introduction of TCM in France is a process of cross-cultural adaptation and coexistence driven by specific health needs in French society,such as chronic disease management and complementary therapies.The French medical community and sociocultural context have not only verified and interpreted TCM through an empirical scientific perspective,but also realized creative localization by developing indigenous schools such as electroacupuncture and auricular acupuncture.Eventually,through institutional measures including national certification,terminology standardization,and networked healthcare services,TCM has been deeply integrated into France’s medical system and social context,forming a stable ecosystem of cross-cultural adaptation and pluralistic coexistence.The French experience,which takes aligning with local health needs as the starting point,stimulating localized cultural innovation as the core,and promoting systematic integration into local systems as the support,presents a picture of traditional medicine serving modern society,the improvement of global health,as well as mutual learning and symbiosis among different civilizations.展开更多
This paper provides a comprehensive summary of the historical background,formulation principles,chemical constituents,pharmacological mechanisms,clinical applications,and quality evaluation of Baatar-7(also referred t...This paper provides a comprehensive summary of the historical background,formulation principles,chemical constituents,pharmacological mechanisms,clinical applications,and quality evaluation of Baatar-7(also referred to as Babu-7 or Qixiong Wan).The findings underscore its potential for broader clinical use and further development through modern pharmaceutical technologies.展开更多
Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cel...Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cell therapy and tissue regeneration.However,cellular senescence induced by replication or external stimuli can impair MSC proliferation and differentiation,making it crucial to develop interventions that delay or reverse the senescence process.From a traditional Chinese medicine perspective,senescence stems from spleen and stomach deficiency,kidney deficiency,and related factors;thus,medicines that tonify the kidney and promote Qi and blood circulation play vital roles in anti-senescence therapy.Chinese medicine,characterized by low toxicity and multi-target,multi-functional properties,has become prominent in anti-senescence research.This paper examines the MSC senescence process by discussing its causes,characteristics,and mechanisms,then summarizes how active ingredients in herbal medicines and natural compounds reverse MSC senescence,facilitating the discovery of additional anti-senescence Chinese medicines and their effective components.展开更多
Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remai...Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remain elusive.Repetitive transcranial magnetic stimulation(rTMS)has emerged as a promising non-invasive intervention;however,its clinical application has been hindered by inconsistent protocols and a lack of mechanistic understanding.A recent landmark study published in Brain Stimulation by Chen et al.addressed these challenges by combining a high-dose intermittent theta-burst stimulation(iTBS)protocol with concurrent transcranial magnetic stimulation-electroencephalography(TMS-EEG).This commentary provides an in-depth analysis of their findings,highlighting the restoration of cerebello-cortical inhibition(CBI)as a key therapeutic mechanism.Furthermore,we discuss the broader implications of this work,proposing that future translational research should integrate accelerated iTBS(aiTBS)paradigms,cortical response measurements(CRM),and individualized neuro-navigation to establish a new era of precision neuromodulation for ataxia.展开更多
The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pat...The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.展开更多
[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD...[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD)based on network pharmacology.[Methods]Firstly,we reviewed the existing research progress on each constituent drug of the Jineijin Shanzha Patch for FD improvement.Following this,identified overlapping genes were utilized to construct both a"Drug-Active Component-FD Target"network and a Protein-Protein Interaction(PPI)network specific to the patch.In addition,Gene Ontology(GO)analysis was carried out.[Results]We identified that the 13 herbs in the Jineijin Shanzha Patch are mainly used for food stagnation,qi stagnation,and spleen deficiency.Screening revealed 43 active patch components,1414 FD-related targets,and 284 shared targets between them.The PPI network analysis further identified the top 10 core targets from these shared targets.From the"Drug-Active Component-FD Target"network,we identified the core elements.These included the herbal components Vignae Semen(from Liushenqu),Crataegi Fructus,and Pseudostellariae Radix;the active components quercetin,genistein,and apigenin;and the key targets CASP3,BCL2,and CASP9.GO analysis of the 284 overlapping targets indicated that the Jineijin Shanzha Patch may exert its therapeutic effects via regulation of biological processes such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway.[Conclusions]The main active components of the Jineijin Shanzha Patch(quercetin,genistein,and apigenin)may improve FD by modulating signaling pathways such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway,thereby acting on key targets including CASP3,BCL2,and CASP9.展开更多
Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish ...Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.展开更多
文摘目的:揭示印度藏药材的品种及主治特点,以及与中国同品种的药名和临床应用异同。方法:从印度出版的Materia Medica of Tibetan Medicine和《世界植物速查辞典》《中国民族药辞典》《藏药晶镜本草》《晶珠本草》中提取和发掘印度和中国使用的藏药材的信息,包括药材藏文名、梵文名、拉丁学名、药材类型、科属名、性味、药用部位和治疗用途等,建立数据库并进行统计和对比分析。结果:本书共收载568味药材,植物类、动物类、矿物类和其它类药材的占比依次为70.07%、10.92%、6.69%和12.32%,涉及161个科和316个属;中国三本专著中记载的同品种共有158味。记载了药性的药材共有228味,其中同品种药材有50味(药性相似的有25味,不相似的有25味)。记载了药味的药材有296味,其中同品种药材有74味(药味相似的有46味,部分相似的有4味,不相似的有24味)。药材的梵文名与印度撰写的藏语发音相似的有181味药材,不相似的有347味;中国藏语发音和印度撰写的藏语发音相似的有91味,不相似的有66味;三种发音均相似的有13味同品种药材,均不相似的有49味。常用药用部位有动物肉类、果实类、根和根茎类、花类、叶类、树皮类和种子类等,而中国使用同品种的药用部位有一定的差异,主要为果实类、种子类、根类、叶类和树皮类等。多用于治疗消化系统疾病、某些传染病和寄生虫病等,常见主治的症状有便秘、中毒和溃疡等,而中国使用同品种的主治有一定的差异,主要用于消化系统疾病、呼吸系统疾病、皮肤和皮下组织疾病等常见主治的症状有消化不良、腹泻和咳嗽等。结论:印度藏药材的品种较丰富,与中国使用的同品种在药性、药味、药用部位及主治等方面均有差异,有助于扩大藏药材的应用价值,藏药材的发音研究提示其来源和使用交流情况。
基金supported by the National Natural Science Foundation of China(No.82360238,82071245)。
文摘Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
文摘Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.
基金Supported by the Project of National Social Science Fund of China (22CMZ015).
文摘The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuling Mountain Area from various perspectives, including geographical indication products, geographical indication trademarks, China s geographical indication products mutually recognized and protected with the EU, geographical indication standards, and the exclusive geographical indication logo. It studies the regional public brand characteristics of Chinese authentic medicinal herbs, based on hometown of authentic Chinese medicinal herbs, advantageous regions of characteristic agricultural products, important agricultural cultural heritage, national famous and excellent new agricultural products, national characteristic agricultural products, geographical indication Chinese well-known trademarks, advantageous regions of characteristic agricultural products, and regional public brands of agricultural products. It analyzes the main problems in the protection of geographical indications and the creation of regional public brands, and proposes suggestions for building high-quality authentic medicinal herb bases, developing new quality productivity in the authentic medicinal herb industry, implementing regional brand strategies for authentic medicinal herbs, constructing a new development pattern of dual circulation authentic medicinal herbs, etc.
文摘Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.
基金the grants from the National Administration of Traditional Chinese Medicine Project for Enhancing Innovation Capabilities in Chinese Medicine(No.BJTH 2024-02F-0009)Shanghai Municipal Health Commission Seed Program for Research and Transformation of Medical New Technologies(No.2024ZZ1006)Shanghai Three-year Action Plan to Further Accelerate the Inheritance and Innovative Development of Traditional Chinese Medicine(No.2025-2027)(3-1-1).
文摘The number of patients with low back pain has increased due to changes in living and working habits.It has become one of the most common diseases in Chinese and Thai clinics.Treatment with Thai traditional medicine can effectively alleviate and manage low back pain.This paper aims to summarize the clinical efficacy and distinctive features of Thai traditional medicine(TTM)in managing low back pain.By reviewing recent literature on TTM treatments,including Thai massage,herbal hot massage,and Thai herbal medicine,the paper aims to lay a foundation for TTM treatment in the world and to promote the convergence and development of traditional Chinese and Thai traditional medicine treatment.Additionally,it advocates for the integration and advancement of both Chinese and Thai traditional medical practices,while also encouraging the dissemination of traditional medicine to other countries globally.
文摘Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。
文摘This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the types,quantities,and shapes of medicinal ingots recorded in Huo Ji Dang(活计档Archives of Imperial Workshops)during the 13-year Yongzheng reign,and by combining these records with existing ingot-related molds,physical specimens,and other collections in the Palace Museum,this research finds that:the Yongzheng Emperor incorporated ingots into the production list of the Imperial Workshop and established standardized preparation procedures,making them a technical practice for displaying imperial power;the fixed system of rewarding ingots during the Dragon Boat Festival turned ingots into a product of Manchu-Han cultural integration and formed a custom;the evolution of ingot equipment was dynamically related to military activities in the mid-Qing dynasty,confirming its function in court politics;and the integration of the preparation and packaging process of ingots into the power operation system,and transforming TCM-related knowledge and technology into means of exercising power,constructed a materialized path for imperial power to regulate the bureaucratic system and social order.The conclusion reveals the inherent logic of the Qing court:establishing authoritative identity through material culture.
基金supported by the National Natural Science Foundation of China[grant numbers 82350003 and 92049201].
文摘Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelectronic devices are now utilized as independent therapeutic interventions or as adjunct treatments,and their applications continue to expand.This article briefly outlines the discovery process of several common electrophysiological signals in the human body and focuses on diverse electrical stimulation technologies.Their applications in the nervous system,cancer treatment,tissue regeneration and repair,and cardiovascular therapy are discussed,along with the underlying mechanisms of action.Furthermore,the rapid development of artificial intelligence and technological innovation has significantly broadened the scope and application of bioelectronic medicine.Finally,the current limitations and future prospects of bioelectronic medicine are explored.
基金supported by The China Ethnic Medicine Association Research Grant(No.2023MY055-81)Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences(2023GLLHD177,2023GLLH0174)Inner Mongolia Autonomous Region Regional Medical Center for Specialized Care(2025).
文摘Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.
基金supported by the National Natural Science Foundation of China(No.82203343)the National Postdoctoral Program for Innovative Talents of China(No.BX20220273)+3 种基金China Postdoctoral Science Foundation(No.2022M712874)Henan Province Key Research and Development Promotion Special Project(Science and Technology)in 2023(No.232102311007)Henan Province Key Scientific Research Project of Colleges and Universities in 2023(No.23A310007)the Outstanding Youth Project of Henan Provincial Natural Science Foundation(No.252300421123)。
文摘Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.
基金financially supported by Beijing Natural Science Foundation(L232085,L222126).
文摘With the advancement of the Belt and Road Initiative and increasing activity in high-altitude regions,the incidence of high-altitude-related diseases has steadily increased.Notably,the prevention and treatment of high-altitude brain injuries remain particularly challenging,making them a key focus of current medical research.The low-pressure and low-oxygen environments at high altitudes significantly increase the risk of hypoxic brain injury.Consequently,understanding the mechanisms that drive these injuries and developing targeted treatments are crucial for maintaining the health of individuals who rapidly ascend to high altitudes.This review examines the mechanisms underlying high-altitude brain injury,outlines the development and evaluation of commonly used animal models for altitude stress,and explores potential therapeutic approaches to support effective prevention and treatment strategies for these conditions.
文摘This paper divides the centuries-long communication of traditional Chinese medicine(TCM)in France into three progressive stages:the first stage(17th to 19th centuries),characterized by academic recognition and knowledge transmission;the second stage(mid-19th century to late 20th century),focusing on clinical verification and school-based innovation;and the third stage(late 20th century to the present),marked by cultural integration and pluralistic coexistence within systems.The introduction of TCM in France is a process of cross-cultural adaptation and coexistence driven by specific health needs in French society,such as chronic disease management and complementary therapies.The French medical community and sociocultural context have not only verified and interpreted TCM through an empirical scientific perspective,but also realized creative localization by developing indigenous schools such as electroacupuncture and auricular acupuncture.Eventually,through institutional measures including national certification,terminology standardization,and networked healthcare services,TCM has been deeply integrated into France’s medical system and social context,forming a stable ecosystem of cross-cultural adaptation and pluralistic coexistence.The French experience,which takes aligning with local health needs as the starting point,stimulating localized cultural innovation as the core,and promoting systematic integration into local systems as the support,presents a picture of traditional medicine serving modern society,the improvement of global health,as well as mutual learning and symbiosis among different civilizations.
基金Supported by National Natural Science Foundation of China(82374346)Double Hundred Outstanding Young and Middle-aged Medical and Health Talents of Wuxi City(BJ2023071)Scientific Research Project of Wuxi Municipal Health Commission(Q202358).
文摘This paper provides a comprehensive summary of the historical background,formulation principles,chemical constituents,pharmacological mechanisms,clinical applications,and quality evaluation of Baatar-7(also referred to as Babu-7 or Qixiong Wan).The findings underscore its potential for broader clinical use and further development through modern pharmaceutical technologies.
基金supported by Zhejiang Provincial Natural Science Foundation of China(No.LQ23H290006)the National Natural Science Foundation of China(No.82204781)+2 种基金the Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province(No.2020E10021)Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents(No.ZWB-2020-18)Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project(No.2023ZR119).
文摘Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cell therapy and tissue regeneration.However,cellular senescence induced by replication or external stimuli can impair MSC proliferation and differentiation,making it crucial to develop interventions that delay or reverse the senescence process.From a traditional Chinese medicine perspective,senescence stems from spleen and stomach deficiency,kidney deficiency,and related factors;thus,medicines that tonify the kidney and promote Qi and blood circulation play vital roles in anti-senescence therapy.Chinese medicine,characterized by low toxicity and multi-target,multi-functional properties,has become prominent in anti-senescence research.This paper examines the MSC senescence process by discussing its causes,characteristics,and mechanisms,then summarizes how active ingredients in herbal medicines and natural compounds reverse MSC senescence,facilitating the discovery of additional anti-senescence Chinese medicines and their effective components.
基金supported by grants from the Open Research Fund of the Zhejiang Key Laboratory of Precision Psychiatry(2025A2)the Natural Science Foundation of Zhejiang Province(LY23C090002)。
文摘Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remain elusive.Repetitive transcranial magnetic stimulation(rTMS)has emerged as a promising non-invasive intervention;however,its clinical application has been hindered by inconsistent protocols and a lack of mechanistic understanding.A recent landmark study published in Brain Stimulation by Chen et al.addressed these challenges by combining a high-dose intermittent theta-burst stimulation(iTBS)protocol with concurrent transcranial magnetic stimulation-electroencephalography(TMS-EEG).This commentary provides an in-depth analysis of their findings,highlighting the restoration of cerebello-cortical inhibition(CBI)as a key therapeutic mechanism.Furthermore,we discuss the broader implications of this work,proposing that future translational research should integrate accelerated iTBS(aiTBS)paradigms,cortical response measurements(CRM),and individualized neuro-navigation to establish a new era of precision neuromodulation for ataxia.
基金supported by the National Natural Science Foundation of China(82574477)the Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Plan(QN202426)+5 种基金Jiangsu Province“333 High-level Talents Training Project”((2024)3-0189)Youth Talent Support Project of the Jiangsu Association for Science and Technology(TJ-2023-053)Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials(KF202401)Fundamental Research Program of Shanxi Province(202403021221211)the research project supported by the Shanxi Scholarship Council of China(No.2023-158)Open Project of Key Laboratory of Tibetan Medicine Basic Research,Ministry of Education.
文摘The global prevalence of metabolic-associated fatty liver disease(MAFLD)is on the rise,seriously threatening human health.Currently,no specific approved drugs are available for its treatment.This paper reviews the pathogenesis of MAFLD,covering aspects like lipid accumulation and insulin resistance,oxidative stress,endoplasmic reticulum stress(ERS),lipotoxicity-induced hepatocyte damage,and fibrosis.It also elaborates on multiple treatment approaches for MAFLD,including metabolic regulation,improvement of the gut-liver axis interaction,modulation of immune and inflammatory pathways,enhancement of the adipose tissue-liver interaction,alleviation of fibrosis,prevention of hepatocyte injury,and traditional Chinese medicine(TCM)external therapies.Additionally,natural product research advancements,individual Chinese medicine components,and mixed herbal formulas for MAFLD treatment is provided.Many natural products and traditional Chinese medicines exhibit favorable effects in regulating lipid metabolism,anti-inflammation,and anti-oxidation,offering new directions and potential drug options for MAFLD treatment.This is expected to provide a reference for future clinical treatment and drug development.
基金Supported by Putuo District Science and Technology R&D Platform Project,Shanghai(2024QX04).
文摘[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD)based on network pharmacology.[Methods]Firstly,we reviewed the existing research progress on each constituent drug of the Jineijin Shanzha Patch for FD improvement.Following this,identified overlapping genes were utilized to construct both a"Drug-Active Component-FD Target"network and a Protein-Protein Interaction(PPI)network specific to the patch.In addition,Gene Ontology(GO)analysis was carried out.[Results]We identified that the 13 herbs in the Jineijin Shanzha Patch are mainly used for food stagnation,qi stagnation,and spleen deficiency.Screening revealed 43 active patch components,1414 FD-related targets,and 284 shared targets between them.The PPI network analysis further identified the top 10 core targets from these shared targets.From the"Drug-Active Component-FD Target"network,we identified the core elements.These included the herbal components Vignae Semen(from Liushenqu),Crataegi Fructus,and Pseudostellariae Radix;the active components quercetin,genistein,and apigenin;and the key targets CASP3,BCL2,and CASP9.GO analysis of the 284 overlapping targets indicated that the Jineijin Shanzha Patch may exert its therapeutic effects via regulation of biological processes such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway.[Conclusions]The main active components of the Jineijin Shanzha Patch(quercetin,genistein,and apigenin)may improve FD by modulating signaling pathways such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway,thereby acting on key targets including CASP3,BCL2,and CASP9.
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
基金General Program of National Natural Science Foundation of China(82474390)Construction Project of Pudong New Area Famous TCM Studios(National Pilot Zone for TCM Development,Shanghai)(PDZY-2025-0716)Shanghai Municipal Science and Technology Program Project Shanghai Key Laboratory of Health Identification and Assessment(21DZ2271000).
文摘Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.
