Objective: To evaluate the essential oil composition and the anti-inflammatory activity of Cymbopogon validus(C. validus) leaves and flowers. Methods: A total of 300 g of fresh or dry(leaves and flowers) of C. validus...Objective: To evaluate the essential oil composition and the anti-inflammatory activity of Cymbopogon validus(C. validus) leaves and flowers. Methods: A total of 300 g of fresh or dry(leaves and flowers) of C. validus were cut into small pieces and subjected to hydro-distillation method for approximately 5 h using the Clevenger apparatus. The extracted essential oils were then used for testing the anti-inflammatory activity. The anti-inflammatory activity was evaluated by using egg-albumin induced paw edema. Results: The extracted oils had the following yields 2.2% for fresh leaves, 2.0% for dry leaves and 2.4% v/w for dry flowers. GCMS results revealed that the oils contained artemisia ketone(37.5%), linalool(3.2%-29.6%), northujane(4.4%-16.8%), verbenone(13.5%), naphthalene(1.7%-9.6%), δ-cadinene(0.5%-8.1%), hedycaryol(5.4%-7.6%) and α-eudesmol(6.5%-6.7%) as the major constituents. C. validus essential oils showed significant(P<0.05) anti-inflammatory effects from the first 30 min after albumin injection compared to aspirin which had a later onset of effect. Conclusions: The findings of this study show that the essential oil extracted from C. validus fresh or dry leaves and flowers have anti-inflammatory properties; that might be associated with the major components and the minor components found in the essential oils.展开更多
基金financially supported by Govan Mbeki Research and Development Centre (GMRDC) (UFH),Directorates of Research,Walter Sisulu University (WSU) and NRF-IKS (UID-82640)
文摘Objective: To evaluate the essential oil composition and the anti-inflammatory activity of Cymbopogon validus(C. validus) leaves and flowers. Methods: A total of 300 g of fresh or dry(leaves and flowers) of C. validus were cut into small pieces and subjected to hydro-distillation method for approximately 5 h using the Clevenger apparatus. The extracted essential oils were then used for testing the anti-inflammatory activity. The anti-inflammatory activity was evaluated by using egg-albumin induced paw edema. Results: The extracted oils had the following yields 2.2% for fresh leaves, 2.0% for dry leaves and 2.4% v/w for dry flowers. GCMS results revealed that the oils contained artemisia ketone(37.5%), linalool(3.2%-29.6%), northujane(4.4%-16.8%), verbenone(13.5%), naphthalene(1.7%-9.6%), δ-cadinene(0.5%-8.1%), hedycaryol(5.4%-7.6%) and α-eudesmol(6.5%-6.7%) as the major constituents. C. validus essential oils showed significant(P<0.05) anti-inflammatory effects from the first 30 min after albumin injection compared to aspirin which had a later onset of effect. Conclusions: The findings of this study show that the essential oil extracted from C. validus fresh or dry leaves and flowers have anti-inflammatory properties; that might be associated with the major components and the minor components found in the essential oils.
