A scheme based on irregular V-shaped silicon nanoantennas is proposed to optimize transverse unidirectional scattering under plane wave irradiation.Traditional methods of designing regular shapes offer fewer parameter...A scheme based on irregular V-shaped silicon nanoantennas is proposed to optimize transverse unidirectional scattering under plane wave irradiation.Traditional methods of designing regular shapes offer fewer parameters and higher search efficiency.However,due to the limitations of regular shapes,it is challenging to meet high-precision design requirements.Irregular shape design allows for a broader range of adjustments,but the complexity of shape parameters leads to lower search efficiency and a higher likelihood of converging to local optima.展开更多
This study examines the “V + Dào” construction as a state change event through the lens of the Event Integration Hypothesis. It focuses on how these constructions represent state changes, exploring distinctions...This study examines the “V + Dào” construction as a state change event through the lens of the Event Integration Hypothesis. It focuses on how these constructions represent state changes, exploring distinctions between “change” and “stasis”. Using a corpus-based approach, the analysis covers the semantic and syntactic features of “V + Dào” constructions and their event integration patterns. The findings highlight the distribution of agency, animacy, and support relations in state change events, emphasizing the complex interaction of internal and external event integrations and their correlation with the conceptual primitives of change and transition. This study offers insights into the lexicalization and grammaticalization processes of the “V + Dào” construction, and potentially the broader verb-complement constructions in Mandarin.展开更多
In this study,the apsidal motion analyses of the eclipsing binary systems V398 Lac,V2544 Cyg,and V785 Cas are presented.The(O-C)diagrams of the selected systems were constructed using all available and reliable times ...In this study,the apsidal motion analyses of the eclipsing binary systems V398 Lac,V2544 Cyg,and V785 Cas are presented.The(O-C)diagrams of the selected systems were constructed using all available and reliable times of minimum light compiled from the literature.As a result,the apsidal motion periods were determined to be 353±50 yr,43.3±5.1 yr and 83.4±8.5 yr,respectively.Furthermore,the TESS light curves of the three systems were analyzed to derive their photometric and absolute parameters.The component masses were determined as follows:for V398 Lac,M_(1)=3.83±0.35 M_(⊙)and M2=3.27±0.35 M_(⊙);for V2544 Cyg,M_(1)=1.75±0.38 M_(⊙)and M2=1.40±0.38 M_(⊙);for V785 Cas,M_(1)=5.64±0.41 M_(⊙)and M2=5.18±0.41 M_(⊙).The parameters related to apsidal motion,as well as the observational and theoretical internal structure constants(K_(2,obs) and K_(2,teo))were calculated for studied binaries.The relativistic contribution to the observed apsidal motion rate was found to be relatively small,constituting less than approximately 5%of the total rate in each system.The theoretical internal structure constants were derived from the evolutionary models,assuming a standard chemical composition of(X,Z)=(0.70,0.01).展开更多
BACKGROUND High levels of acetaminophen(APAP)consumption can result in significant liver toxicity.Mogroside V(MV)is a bioactive,plant-derived triterpenoid known for its various pharmacological activities.However,the i...BACKGROUND High levels of acetaminophen(APAP)consumption can result in significant liver toxicity.Mogroside V(MV)is a bioactive,plant-derived triterpenoid known for its various pharmacological activities.However,the impact of MV on acute liver injury(ALI)is unknown.AIM To investigate the hepatoprotective potential of MV against liver damage caused by APAP and to examine the underlying mechanisms.METHODS Mice were divided into three groups:Saline,APAP and APAP+MV.MV(10 mg/kg)was given intraperitoneally one hour before APAP(300 mg/kg)administration.Twenty-four hours after APAP exposure,serum transaminase levels,liver necrotic area,inflammatory responses,nitrotyrosine accumulation,and c-jun-N-terminal kinase(JNK)activation were assessed.Additionally,we analyzed reactive oxygen species(ROS)levels,JNK activation,and cell death in alpha mouse liver 12(AML12)cells.RESULTS MV pre-treatment in vivo led to a reduction in the rise of aspartate transaminase and alanine transaminase levels,mitigated liver damage,decreased nitrotyrosine accumulation,and blocked JNK phosphorylation resulting from APAP exposure,without affecting glutathione production.Similarly,MV diminished the APAP-induced increase in ROS,JNK phosphorylation,and cell death in vitro.CONCLUSION Our study suggests that MV treatment alleviates APAP-induced ALI by reducing ROS and JNK activation.展开更多
基金supported by the National Natural Science Foundation of China(Nos.62475121 and 62335012)。
文摘A scheme based on irregular V-shaped silicon nanoantennas is proposed to optimize transverse unidirectional scattering under plane wave irradiation.Traditional methods of designing regular shapes offer fewer parameters and higher search efficiency.However,due to the limitations of regular shapes,it is challenging to meet high-precision design requirements.Irregular shape design allows for a broader range of adjustments,but the complexity of shape parameters leads to lower search efficiency and a higher likelihood of converging to local optima.
文摘This study examines the “V + Dào” construction as a state change event through the lens of the Event Integration Hypothesis. It focuses on how these constructions represent state changes, exploring distinctions between “change” and “stasis”. Using a corpus-based approach, the analysis covers the semantic and syntactic features of “V + Dào” constructions and their event integration patterns. The findings highlight the distribution of agency, animacy, and support relations in state change events, emphasizing the complex interaction of internal and external event integrations and their correlation with the conceptual primitives of change and transition. This study offers insights into the lexicalization and grammaticalization processes of the “V + Dào” construction, and potentially the broader verb-complement constructions in Mandarin.
基金Funding for TESS is provided by the NASA Science Mission Directorate。
文摘In this study,the apsidal motion analyses of the eclipsing binary systems V398 Lac,V2544 Cyg,and V785 Cas are presented.The(O-C)diagrams of the selected systems were constructed using all available and reliable times of minimum light compiled from the literature.As a result,the apsidal motion periods were determined to be 353±50 yr,43.3±5.1 yr and 83.4±8.5 yr,respectively.Furthermore,the TESS light curves of the three systems were analyzed to derive their photometric and absolute parameters.The component masses were determined as follows:for V398 Lac,M_(1)=3.83±0.35 M_(⊙)and M2=3.27±0.35 M_(⊙);for V2544 Cyg,M_(1)=1.75±0.38 M_(⊙)and M2=1.40±0.38 M_(⊙);for V785 Cas,M_(1)=5.64±0.41 M_(⊙)and M2=5.18±0.41 M_(⊙).The parameters related to apsidal motion,as well as the observational and theoretical internal structure constants(K_(2,obs) and K_(2,teo))were calculated for studied binaries.The relativistic contribution to the observed apsidal motion rate was found to be relatively small,constituting less than approximately 5%of the total rate in each system.The theoretical internal structure constants were derived from the evolutionary models,assuming a standard chemical composition of(X,Z)=(0.70,0.01).
基金Supported by Guangxi Natural Science Foundation of China,No.2024GXNSFAA010040Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department,No.GuikeZY21195024National Natural Science Foundation of China,No.82260499 and No.82460463.
文摘BACKGROUND High levels of acetaminophen(APAP)consumption can result in significant liver toxicity.Mogroside V(MV)is a bioactive,plant-derived triterpenoid known for its various pharmacological activities.However,the impact of MV on acute liver injury(ALI)is unknown.AIM To investigate the hepatoprotective potential of MV against liver damage caused by APAP and to examine the underlying mechanisms.METHODS Mice were divided into three groups:Saline,APAP and APAP+MV.MV(10 mg/kg)was given intraperitoneally one hour before APAP(300 mg/kg)administration.Twenty-four hours after APAP exposure,serum transaminase levels,liver necrotic area,inflammatory responses,nitrotyrosine accumulation,and c-jun-N-terminal kinase(JNK)activation were assessed.Additionally,we analyzed reactive oxygen species(ROS)levels,JNK activation,and cell death in alpha mouse liver 12(AML12)cells.RESULTS MV pre-treatment in vivo led to a reduction in the rise of aspartate transaminase and alanine transaminase levels,mitigated liver damage,decreased nitrotyrosine accumulation,and blocked JNK phosphorylation resulting from APAP exposure,without affecting glutathione production.Similarly,MV diminished the APAP-induced increase in ROS,JNK phosphorylation,and cell death in vitro.CONCLUSION Our study suggests that MV treatment alleviates APAP-induced ALI by reducing ROS and JNK activation.
