BACKGROUND Depression significantly threatens human health.Purinergic receptors are reported to be associated with depression.However,there is no bibliometric research in this field have been published.AIM To provide ...BACKGROUND Depression significantly threatens human health.Purinergic receptors are reported to be associated with depression.However,there is no bibliometric research in this field have been published.AIM To provide some reference for the further research in the field of purinergic receptors and depression utilizing bibliometric analysis.METHODS Relevant researches were retrieved from the Web of Science Core Collection database.The period of the search was from January 1,2003 to December 31,2023.The CiteSpace(6.2.R7)and VOSviewer(1.6.19)were applied to identify the main contributors of countries,authors,institutions,references and journals.Besides,we evaluate keywords to assess the hotspots and trends over the previous 2 decades.RESULTS Totally,247 articles were identified,showing an increasing trend over time.The most productive country,institution,and journal in this field are China,Harvard University,and Biological Psychiatry,respectively.Liang SD and Rodrigues,Ana Lucia S were the most prolific authors.Burnstock G ranked first among the cited authors.The cooperation among countries and disciplines is crucial.The P2X7 receptor provides promising prospects for treating depression and further studies are warranted to validate the scope and significance of depression therapeutic strategies.CONCLUSION This study provides an overview of the worldwide research status and future trends in purinergic receptors and depression.P2X7 receptor is considered an appropriate target for the treatment of depression,as well as neurological diseases.It is implied that based on purinergic system,the future prospects for interventions aimed at depression treatment are promising,showing the way for both augmentation strategies and new drug treatments in the context of the pharmacology of depression.展开更多
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'...Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.展开更多
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A...The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.展开更多
AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current resea...AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains i...To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers.展开更多
Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may po...Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management.展开更多
Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i...Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.展开更多
Purpose:Citations can be used in evaluative bibliometrics to measure the impact of papers.However,citation analysis can be extended by a multi-dimensional perspective on citation impact which is intended to receive mo...Purpose:Citations can be used in evaluative bibliometrics to measure the impact of papers.However,citation analysis can be extended by a multi-dimensional perspective on citation impact which is intended to receive more specific information about the kind of received impact.Design/methodology/approach:Bornmann,Wray,and Haunschild(2019)introduced citation concept analysis(CCA)for capturing the importance and usefulness certain concepts have in subsequent research.The method is based on the analysis of citances-the contexts of citations in citing papers.This study applies the method by investigating the impact of various concepts introduced in the oeuvre of the world-leading French sociologist Pierre Bourdieu.Findings:We found that the most cited concepts are‘social capital’(with about 34%of the citances in the citing papers),‘cultural capital’,and‘habitus’(both with about 24%).On the other hand,the concepts‘doxa’and‘reflexivity’score only about 1%each.Research limitations:The formulation of search terms for identifying the concepts in the data and the citation context coverage are the most important limitations of the study.Practical implications:The results of this explorative study reflect the historical development of Bourdieu’s thought and its interface with different fields of study.Originality/value:The study demonstrates the high explanatory power of the CCA method.展开更多
A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis （CE） with direct chemiluminescence （CL） detection is described. The detection limits （S/N= 3） were 1.3 × 10...A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis （CE） with direct chemiluminescence （CL） detection is described. The detection limits （S/N= 3） were 1.3 × 10^-8 g/mL for isoprenaline, 1.0 × 10^-8g/mL for epinephrine and 2.8 × 10^-8 g/mL for dopamine. The proposed method was successfully applied to the analysis of catecholamines in urine samples of cigarette smokers and nonsmokers. The results showed that there is a close relation between the release of dopamine in human body fluids and cigarette smoking/nonsmoking.展开更多
The fracture volume is gradually changed with the depletion of fracture pressure during the production process.However,there are few flowback models available so far that can estimate the fracture volume loss using pr...The fracture volume is gradually changed with the depletion of fracture pressure during the production process.However,there are few flowback models available so far that can estimate the fracture volume loss using pressure transient and rate transient data.The initial flowback involves producing back the fracturing fuid after hydraulic fracturing,while the second flowback involves producing back the preloading fluid injected into the parent wells before fracturing of child wells.The main objective of this research is to compare the initial and second flowback data to capture the changes in fracture volume after production and preload processes.Such a comparison is useful for evaluating well performance and optimizing frac-turing operations.We construct rate-normalized pressure(RNP)versus material balance time(MBT)diagnostic plots using both initial and second flowback data(FB;and FBs,respectively)of six multi-fractured horizontal wells completed in Niobrara and Codell formations in DJ Basin.In general,the slope of RNP plot during the FB,period is higher than that during the FB;period,indicating a potential loss of fracture volume from the FB;to the FB,period.We estimate the changes in effective fracture volume(Ver)by analyzing the changes in the RNP slope and total compressibility between these two flowback periods.Ver during FB,is in general 3%-45%lower than that during FB:.We also compare the drive mechanisms for the two flowback periods by calculating the compaction-drive index(CDI),hydrocarbon-drive index(HDI),and water-drive index(WDI).The dominant drive mechanism during both flowback periods is CDI,but its contribution is reduced by 16%in the FB,period.This drop is generally compensated by a relatively higher HDI during this period.The loss of effective fracture volume might be attributed to the pressure depletion in fractures,which occurs during the production period and can extend 800 days.展开更多
A simple, rapid, sensitive and reproducible method for enantiomer analysis of methamphetamine, amphetamine, cathinone and methcathinone was developed and validated. The compounds were extracted from equine plasma and ...A simple, rapid, sensitive and reproducible method for enantiomer analysis of methamphetamine, amphetamine, cathinone and methcathinone was developed and validated. The compounds were extracted from equine plasma and urine using a fast liquid-liquid extraction procedure. Only one milliliter plasma and one hundred microliter urine sample is needed for analysis. The extraction procedure had good recovery (>70%) and the matrix effect was negligible. Enantiomer differentiation and confirmation were achieved using liquid chromatography with chiral stationary phase and mass spectrometry detection. The method demonstrated excellent reproducibility with intra-day and inter-day precision of lower than 5%. The lower limits of detection for all of the compounds studied here were at low pg/mL level for both plasma and urine. This is the first report of the analysis of four chiral compounds in equine plasma and urine. Routine application was demonstrated for (S)- and (R)-enantiomer differentiation.展开更多
In order to analysis the oxygen distribution in the adsorption bed during the hydrogen purification process from oxygen-containing feed gas and the safety of device operation, this article established a non-isothermal...In order to analysis the oxygen distribution in the adsorption bed during the hydrogen purification process from oxygen-containing feed gas and the safety of device operation, this article established a non-isothermal model for the pressure swing adsorption (PSA) separation process of 4-component (H_(2)/O_(2)/N_(2)/CH_(4)), and adopted a composite adsorption bed of activated carbon and molecular sieve. In this article, the oxygen distribution in the adsorption bed under different feed gas oxygen contents, different adsorption pressures, and different product hydrogen purity was studied for both vacuuming process and purging process. The study shows that during the process from the end of adsorption to the end of providing purging, the peak value of oxygen concentration in the adsorption bed gradually increases, with the highest value exceeding 30 times the oxygen content of the feed gas. Moreover, the concentration multiplier of oxygen in the adsorption bed increases with the increase of the adsorption pressure, decreases with the increase of the oxygen content in the feed gas, and increases with the decrease of the hydrogen product purity. When the oxygen content in the feed gas reaches 0.3% (vol), the peak value of oxygen concentration in the adsorption bed exceeds 10% (vol), which will make the front part of the oxygen concentration peak fall in an explosion limit range. As the decrease of product hydrogen content, the oxygen concentration peak in the adsorption bed will gradually move forward to the adsorption bed outlet, and even penetrate through the adsorption bed. And during the process of the oxygen concentration peak moving forward, the oxygen will enter the pipeline at the outlet of the adsorption bed, which will make the pipeline space of high-speed gas flow into an explosion range, bringing great risk to the device. The preferred option for safe operation of PSA for hydrogen purification from oxygen-containing feed gas is to deoxygenate the feed gas. When deoxygenation is not available, a lower adsorption pressure and a higher product hydrogen purity (greater than or equal to 99.9% (vol)) can be used to avoid the gas in the adsorption bed outlet pipeline being in the explosion range.展开更多
Objective This study aims to analyze the current state and emerging trends in research articles related to acupuncture treatment for low back pain(LBP).Methods The Web of Science core database was utilized to retrieve...Objective This study aims to analyze the current state and emerging trends in research articles related to acupuncture treatment for low back pain(LBP).Methods The Web of Science core database was utilized to retrieve relevant literature on acupuncture therapy for LBP from January 1,1997,to August 29,2023.Literature metrics analysis was conducted using Microsoft Excel,VOSviewer,SCImago Graphica,and Pajek.The analysis focused on annual publication volume,countries(regions),institutions,authors,journals,keywords,and references.Results A total of 1,434 papers on acupuncture treatment for LBP were identified,demonstrating a fluctuating growth trend over the past 25 years.Research in this field has been conducted in 57 countries,with the United States leading in terms of research output.Italy emerged as the country with the highest-quality publications,with an average citation frequency of 205.16 times.A total of 1,781 institutions contributed to research on acupuncture treatment for LBP,with Harvard University having the highest publication volume(cited 77 times).The number of authors contributing to this field reached 5,696,with In-Hyuk Ha having the highest publication count(31 papers)and Claudia-M.Witt is the most influential author(cited 2,699 times).Relevant research was published in 378 journals,with the Journal of Alternative and Complementary Medicine having the highest publication volume(77 papers),and Spine being the most influential journal(cited 3,420 times).A total of 3,854 keywords were identified,forming six main thematic clusters:care management,nerve stimulation,complementary medicine,pregnancy pain,rehabilitation research,and musculoskeletal pain.Twelve highly cited papers with citation frequencies≥85 times were recognized,predominantly consisting of randomized controlled trials.Conclusion Over the past 25 years,the number of articles published on acupuncture for LPB has shown a fluctuating trend of growth;the distribution of countries(regions)and institutions that publish articles is scattered,mainly based on inter-regional cooperation,and international cooperation is still insufficient;Journals in alternative and integrative medicine category provide references for scholars to submit manuscripts and learn about the frontiers;Acupuncture is effective and economical in the treatment of pain,and it has been widely used in the treatment of low back pain.However,the difference in efficacy between acupuncture and sham acupuncture or placebo acupuncture remains controversial.Therefore,in the future,it is necessary to consider the selection of appropriate efficacy evaluation methods in clinical trials that reflect the therapeutic advantages of acupuncture.展开更多
Recent advances in artificial intelligence(AI)have led to the development of sophisticated algorithms that significantly improve image analysis capabilities.This combination of AI and microscopic imaging is transformi...Recent advances in artificial intelligence(AI)have led to the development of sophisticated algorithms that significantly improve image analysis capabilities.This combination of AI and microscopic imaging is transforming the way we interpret and analyze imaging data,simplifying complex tasks and enabling innovative experimental methods previously thought impossible.In smart manufacturing,these improvements are especially impactful,increasing precision and efficiency in production processes.This review examines the convergence of AI with particle image analysis,an area we refer to as“particle vision analysis(PVA).”We offer a detailed overview of how this technology integrates into and impacts various fields within the physical sciences and materials sectors,where it plays a crucial role in both innovation and operational improvements.We explore four key areas of advancement-namely,particle classification,detection,segmentation,and object tracking-along with a look into the emerging field of augmented microscopy.This paper also underscores the vital role of the existing datasets and implementations that support these applications,which provide essential insights and resources that drive continuous research and development in this fast-evolving field.Our thorough analysis aims to outline the transformative potential of AI-driven PVA in improving precision in future manufacturing at the microscopic scale and thereby preparing the ground for significant technological progress and broad industrial applications in nanomanufacturing,biomanufacturing,and pharmaceutical manufacturing.This exploration not only highlights the advantages of integrating AI into conventional manufacturing processes but also anticipates the rise of next-generation smart manufacturing,which is set to revolutionize industry standards and operational practices.展开更多
Purpose:Policies have often,albeit inadvertently,overlooked certain scientific insights,especially in the handling of complex events.This study aims to systematically uncover and evaluate pivotal scientific insights t...Purpose:Policies have often,albeit inadvertently,overlooked certain scientific insights,especially in the handling of complex events.This study aims to systematically uncover and evaluate pivotal scientific insights that have been underrepresented in policy documents by leveraging extensive datasets from policy texts and scholarly publications.Design/methodology/approach:This article introduces a research framework aimed at excavating scientific insights that have been overlooked by policy,encompassing four integral parts:data acquisition and preprocessing,the identification of overlooked content through thematic analysis,the discovery of overlooked content via keyword analysis,and a comprehensive analysis and discussion of the overlooked content.Leveraging this framework,the research conducts an in-depth exploration of the scientific content overlooked by policies during the COVID-19 pandemic.Findings:During the COVID-19 pandemic,scientific information in four domains was overlooked by policy:psychological state of the populace,environmental issues,the role of computer technology,and public relations.These findings indicate a systematic underrepresentation of important scientific insights in policy.Research limitations:This study is subject to two key limitations.Firstly,the text analysis method—relying on pre-extracted keywords and thematic structures—may not fully capture the nuanced context and complexity of scientific insights in policy documents.Secondly,the focus on a limited set of case studies restricts the broader applicability of the conclusions across diverse situations.Practical implications:The study introduces a quantitative framework using text analysis to identify overlooked scientific content in policy,bridging the gap between science and policy.It also highlights overlooked scientific information during COVID-19,promoting more evidence-based and robust policies through improved science-policy integration.Originality/value:This paper provides new ideas and methods for excavating scientific information that has been overlooked by policy,further deepens the understanding of the interaction between policy and science during the COVID-19 period,and lays the foundation for the more rational use of scientific information in policy-making.展开更多
As the demand for intelligent and flexible production in the automotive manufacturing industry continues to intensify,industrial automation enterprises are gaining ever-greater market opportunities and competitive adv...As the demand for intelligent and flexible production in the automotive manufacturing industry continues to intensify,industrial automation enterprises are gaining ever-greater market opportunities and competitive advantages in this field.Based on a literature review and representative case studies,this paper constructs a theoretical framework for growth strategies and systematically analyzes the current application status and growth paths of automation enterprises in both complete vehicle and component production.The research finds that different growth strategies(such as vertical integration,horizontal diversification,and digital service transformation)exhibit varying applicability across upstream and downstream segments of automotive manufacturing,while simultaneously facing challenges related to technology integration,business models,and organizational change.In response to these issues,this paper proposes countermeasures such as optimizing R&D and customer relationship management,improving branding and after-sales service systems,and strengthening policy and industry environment support,thereby offering guidance for sustainable growth of industrial automation enterprises in the automotive manufacturing sector.展开更多
The textile industry,while creating material wealth,also exerts a significant impact on the environment.Particularly in the textile manufacturing phase,which is the most energy-intensive phase throughout the product l...The textile industry,while creating material wealth,also exerts a significant impact on the environment.Particularly in the textile manufacturing phase,which is the most energy-intensive phase throughout the product lifecycle,the problem of high energy usage is increasingly notable.Nevertheless,current analyses of carbon emissions in textile manufacturing emphasize the dynamic temporal characteristics while failing to adequately consider critical information such as material flows and energy consumption.A carbon emission analysis method based on a holographic process model(HPM)is proposed to address these issues.First,the system boundary in the textile manufacturing is defined,and the characteristics of carbon emissions are analyzed.Next,an HPM based on the object-centric Petri net(OCPN)is constructed,and simulation experiments are conducted on three different scenarios in the textile manufacturing.Subsequently,the constructed HPM is utilized to achieve a multi-perspective analysis of carbon emissions.Finally,the feasibility of the method is verified by using the production data of pure cotton products from a certain textile manufacturing enterprise.The results indicate that this method can analyze the impact of various factors on the carbon emissions of pure cotton product production,and by applying targeted optimization strategies,carbon emissions have been reduced by nearly 20%.This contributes to propelling the textile manufacturing industry toward sustainable development.展开更多
基金Supported by the National Key Research and Development Program of China,No.2019YFC1709703Jiangxi Provincial Science and Technology Department,No.20212BAG70037+1 种基金Jiangxi Provincial Education Department Science Program,No.GJJ201259Jiangxi Provincial Administration of Traditional Chinese Medicine,No.2021B324.
文摘BACKGROUND Depression significantly threatens human health.Purinergic receptors are reported to be associated with depression.However,there is no bibliometric research in this field have been published.AIM To provide some reference for the further research in the field of purinergic receptors and depression utilizing bibliometric analysis.METHODS Relevant researches were retrieved from the Web of Science Core Collection database.The period of the search was from January 1,2003 to December 31,2023.The CiteSpace(6.2.R7)and VOSviewer(1.6.19)were applied to identify the main contributors of countries,authors,institutions,references and journals.Besides,we evaluate keywords to assess the hotspots and trends over the previous 2 decades.RESULTS Totally,247 articles were identified,showing an increasing trend over time.The most productive country,institution,and journal in this field are China,Harvard University,and Biological Psychiatry,respectively.Liang SD and Rodrigues,Ana Lucia S were the most prolific authors.Burnstock G ranked first among the cited authors.The cooperation among countries and disciplines is crucial.The P2X7 receptor provides promising prospects for treating depression and further studies are warranted to validate the scope and significance of depression therapeutic strategies.CONCLUSION This study provides an overview of the worldwide research status and future trends in purinergic receptors and depression.P2X7 receptor is considered an appropriate target for the treatment of depression,as well as neurological diseases.It is implied that based on purinergic system,the future prospects for interventions aimed at depression treatment are promising,showing the way for both augmentation strategies and new drug treatments in the context of the pharmacology of depression.
文摘Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金financially supported by the National Natural Science Foundation of China(Nos.52034002 and U2202254)the Fundamental Research Funds for the Central Universities,China(No.FRF-TT-19-001)。
文摘The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.
基金Suppotred by Tianjin Key Medical Discipline Construction Project(No.TJYXZDXK-3-004A-2).
文摘AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
文摘To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers.
基金supported by the National Natural Science Foundation of China(No.22176200)the Industrial Innovation Entrepreneurial Team Project of Ordos 2021.
文摘Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management.
文摘Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.
文摘Purpose:Citations can be used in evaluative bibliometrics to measure the impact of papers.However,citation analysis can be extended by a multi-dimensional perspective on citation impact which is intended to receive more specific information about the kind of received impact.Design/methodology/approach:Bornmann,Wray,and Haunschild(2019)introduced citation concept analysis(CCA)for capturing the importance and usefulness certain concepts have in subsequent research.The method is based on the analysis of citances-the contexts of citations in citing papers.This study applies the method by investigating the impact of various concepts introduced in the oeuvre of the world-leading French sociologist Pierre Bourdieu.Findings:We found that the most cited concepts are‘social capital’(with about 34%of the citances in the citing papers),‘cultural capital’,and‘habitus’(both with about 24%).On the other hand,the concepts‘doxa’and‘reflexivity’score only about 1%each.Research limitations:The formulation of search terms for identifying the concepts in the data and the citation context coverage are the most important limitations of the study.Practical implications:The results of this explorative study reflect the historical development of Bourdieu’s thought and its interface with different fields of study.Originality/value:The study demonstrates the high explanatory power of the CCA method.
基金the National Natural Science Foundation of China （No. 20575056） the 0utstanding Youth Science Foundation of Henan Province （No. 04120001300） Henan Innovation Project for University Research Talents （No. 2005126）.
文摘A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis （CE） with direct chemiluminescence （CL） detection is described. The detection limits （S/N= 3） were 1.3 × 10^-8 g/mL for isoprenaline, 1.0 × 10^-8g/mL for epinephrine and 2.8 × 10^-8 g/mL for dopamine. The proposed method was successfully applied to the analysis of catecholamines in urine samples of cigarette smokers and nonsmokers. The results showed that there is a close relation between the release of dopamine in human body fluids and cigarette smoking/nonsmoking.
文摘The fracture volume is gradually changed with the depletion of fracture pressure during the production process.However,there are few flowback models available so far that can estimate the fracture volume loss using pressure transient and rate transient data.The initial flowback involves producing back the fracturing fuid after hydraulic fracturing,while the second flowback involves producing back the preloading fluid injected into the parent wells before fracturing of child wells.The main objective of this research is to compare the initial and second flowback data to capture the changes in fracture volume after production and preload processes.Such a comparison is useful for evaluating well performance and optimizing frac-turing operations.We construct rate-normalized pressure(RNP)versus material balance time(MBT)diagnostic plots using both initial and second flowback data(FB;and FBs,respectively)of six multi-fractured horizontal wells completed in Niobrara and Codell formations in DJ Basin.In general,the slope of RNP plot during the FB,period is higher than that during the FB;period,indicating a potential loss of fracture volume from the FB;to the FB,period.We estimate the changes in effective fracture volume(Ver)by analyzing the changes in the RNP slope and total compressibility between these two flowback periods.Ver during FB,is in general 3%-45%lower than that during FB:.We also compare the drive mechanisms for the two flowback periods by calculating the compaction-drive index(CDI),hydrocarbon-drive index(HDI),and water-drive index(WDI).The dominant drive mechanism during both flowback periods is CDI,but its contribution is reduced by 16%in the FB,period.This drop is generally compensated by a relatively higher HDI during this period.The loss of effective fracture volume might be attributed to the pressure depletion in fractures,which occurs during the production period and can extend 800 days.
文摘A simple, rapid, sensitive and reproducible method for enantiomer analysis of methamphetamine, amphetamine, cathinone and methcathinone was developed and validated. The compounds were extracted from equine plasma and urine using a fast liquid-liquid extraction procedure. Only one milliliter plasma and one hundred microliter urine sample is needed for analysis. The extraction procedure had good recovery (>70%) and the matrix effect was negligible. Enantiomer differentiation and confirmation were achieved using liquid chromatography with chiral stationary phase and mass spectrometry detection. The method demonstrated excellent reproducibility with intra-day and inter-day precision of lower than 5%. The lower limits of detection for all of the compounds studied here were at low pg/mL level for both plasma and urine. This is the first report of the analysis of four chiral compounds in equine plasma and urine. Routine application was demonstrated for (S)- and (R)-enantiomer differentiation.
基金support provided by the Sichuan Province Science and Technology Achievement Transformation Project (2023ZHCG0063).
文摘In order to analysis the oxygen distribution in the adsorption bed during the hydrogen purification process from oxygen-containing feed gas and the safety of device operation, this article established a non-isothermal model for the pressure swing adsorption (PSA) separation process of 4-component (H_(2)/O_(2)/N_(2)/CH_(4)), and adopted a composite adsorption bed of activated carbon and molecular sieve. In this article, the oxygen distribution in the adsorption bed under different feed gas oxygen contents, different adsorption pressures, and different product hydrogen purity was studied for both vacuuming process and purging process. The study shows that during the process from the end of adsorption to the end of providing purging, the peak value of oxygen concentration in the adsorption bed gradually increases, with the highest value exceeding 30 times the oxygen content of the feed gas. Moreover, the concentration multiplier of oxygen in the adsorption bed increases with the increase of the adsorption pressure, decreases with the increase of the oxygen content in the feed gas, and increases with the decrease of the hydrogen product purity. When the oxygen content in the feed gas reaches 0.3% (vol), the peak value of oxygen concentration in the adsorption bed exceeds 10% (vol), which will make the front part of the oxygen concentration peak fall in an explosion limit range. As the decrease of product hydrogen content, the oxygen concentration peak in the adsorption bed will gradually move forward to the adsorption bed outlet, and even penetrate through the adsorption bed. And during the process of the oxygen concentration peak moving forward, the oxygen will enter the pipeline at the outlet of the adsorption bed, which will make the pipeline space of high-speed gas flow into an explosion range, bringing great risk to the device. The preferred option for safe operation of PSA for hydrogen purification from oxygen-containing feed gas is to deoxygenate the feed gas. When deoxygenation is not available, a lower adsorption pressure and a higher product hydrogen purity (greater than or equal to 99.9% (vol)) can be used to avoid the gas in the adsorption bed outlet pipeline being in the explosion range.
基金Supported by the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences:CI2021B002.
文摘Objective This study aims to analyze the current state and emerging trends in research articles related to acupuncture treatment for low back pain(LBP).Methods The Web of Science core database was utilized to retrieve relevant literature on acupuncture therapy for LBP from January 1,1997,to August 29,2023.Literature metrics analysis was conducted using Microsoft Excel,VOSviewer,SCImago Graphica,and Pajek.The analysis focused on annual publication volume,countries(regions),institutions,authors,journals,keywords,and references.Results A total of 1,434 papers on acupuncture treatment for LBP were identified,demonstrating a fluctuating growth trend over the past 25 years.Research in this field has been conducted in 57 countries,with the United States leading in terms of research output.Italy emerged as the country with the highest-quality publications,with an average citation frequency of 205.16 times.A total of 1,781 institutions contributed to research on acupuncture treatment for LBP,with Harvard University having the highest publication volume(cited 77 times).The number of authors contributing to this field reached 5,696,with In-Hyuk Ha having the highest publication count(31 papers)and Claudia-M.Witt is the most influential author(cited 2,699 times).Relevant research was published in 378 journals,with the Journal of Alternative and Complementary Medicine having the highest publication volume(77 papers),and Spine being the most influential journal(cited 3,420 times).A total of 3,854 keywords were identified,forming six main thematic clusters:care management,nerve stimulation,complementary medicine,pregnancy pain,rehabilitation research,and musculoskeletal pain.Twelve highly cited papers with citation frequencies≥85 times were recognized,predominantly consisting of randomized controlled trials.Conclusion Over the past 25 years,the number of articles published on acupuncture for LPB has shown a fluctuating trend of growth;the distribution of countries(regions)and institutions that publish articles is scattered,mainly based on inter-regional cooperation,and international cooperation is still insufficient;Journals in alternative and integrative medicine category provide references for scholars to submit manuscripts and learn about the frontiers;Acupuncture is effective and economical in the treatment of pain,and it has been widely used in the treatment of low back pain.However,the difference in efficacy between acupuncture and sham acupuncture or placebo acupuncture remains controversial.Therefore,in the future,it is necessary to consider the selection of appropriate efficacy evaluation methods in clinical trials that reflect the therapeutic advantages of acupuncture.
基金funding support from the US National Science Foundation(2229092)supported by the Eric and Wendy Schmidt AI in Science Postdoctoral Fellowship,a program of Schmidt Sciences,LLC.
文摘Recent advances in artificial intelligence(AI)have led to the development of sophisticated algorithms that significantly improve image analysis capabilities.This combination of AI and microscopic imaging is transforming the way we interpret and analyze imaging data,simplifying complex tasks and enabling innovative experimental methods previously thought impossible.In smart manufacturing,these improvements are especially impactful,increasing precision and efficiency in production processes.This review examines the convergence of AI with particle image analysis,an area we refer to as“particle vision analysis(PVA).”We offer a detailed overview of how this technology integrates into and impacts various fields within the physical sciences and materials sectors,where it plays a crucial role in both innovation and operational improvements.We explore four key areas of advancement-namely,particle classification,detection,segmentation,and object tracking-along with a look into the emerging field of augmented microscopy.This paper also underscores the vital role of the existing datasets and implementations that support these applications,which provide essential insights and resources that drive continuous research and development in this fast-evolving field.Our thorough analysis aims to outline the transformative potential of AI-driven PVA in improving precision in future manufacturing at the microscopic scale and thereby preparing the ground for significant technological progress and broad industrial applications in nanomanufacturing,biomanufacturing,and pharmaceutical manufacturing.This exploration not only highlights the advantages of integrating AI into conventional manufacturing processes but also anticipates the rise of next-generation smart manufacturing,which is set to revolutionize industry standards and operational practices.
基金financially supported by the Ningbo University of Technology New Faculty Research Fundthe 2023 Interdisciplinary Innovation Research Cultivation Program of School of Interdisciplinary Studies,RUCKey Project of the National Social Science Foundation of China(21ATQ008)。
文摘Purpose:Policies have often,albeit inadvertently,overlooked certain scientific insights,especially in the handling of complex events.This study aims to systematically uncover and evaluate pivotal scientific insights that have been underrepresented in policy documents by leveraging extensive datasets from policy texts and scholarly publications.Design/methodology/approach:This article introduces a research framework aimed at excavating scientific insights that have been overlooked by policy,encompassing four integral parts:data acquisition and preprocessing,the identification of overlooked content through thematic analysis,the discovery of overlooked content via keyword analysis,and a comprehensive analysis and discussion of the overlooked content.Leveraging this framework,the research conducts an in-depth exploration of the scientific content overlooked by policies during the COVID-19 pandemic.Findings:During the COVID-19 pandemic,scientific information in four domains was overlooked by policy:psychological state of the populace,environmental issues,the role of computer technology,and public relations.These findings indicate a systematic underrepresentation of important scientific insights in policy.Research limitations:This study is subject to two key limitations.Firstly,the text analysis method—relying on pre-extracted keywords and thematic structures—may not fully capture the nuanced context and complexity of scientific insights in policy documents.Secondly,the focus on a limited set of case studies restricts the broader applicability of the conclusions across diverse situations.Practical implications:The study introduces a quantitative framework using text analysis to identify overlooked scientific content in policy,bridging the gap between science and policy.It also highlights overlooked scientific information during COVID-19,promoting more evidence-based and robust policies through improved science-policy integration.Originality/value:This paper provides new ideas and methods for excavating scientific information that has been overlooked by policy,further deepens the understanding of the interaction between policy and science during the COVID-19 period,and lays the foundation for the more rational use of scientific information in policy-making.
文摘As the demand for intelligent and flexible production in the automotive manufacturing industry continues to intensify,industrial automation enterprises are gaining ever-greater market opportunities and competitive advantages in this field.Based on a literature review and representative case studies,this paper constructs a theoretical framework for growth strategies and systematically analyzes the current application status and growth paths of automation enterprises in both complete vehicle and component production.The research finds that different growth strategies(such as vertical integration,horizontal diversification,and digital service transformation)exhibit varying applicability across upstream and downstream segments of automotive manufacturing,while simultaneously facing challenges related to technology integration,business models,and organizational change.In response to these issues,this paper proposes countermeasures such as optimizing R&D and customer relationship management,improving branding and after-sales service systems,and strengthening policy and industry environment support,thereby offering guidance for sustainable growth of industrial automation enterprises in the automotive manufacturing sector.
基金National Key R&D Program of China(No.2019YFB1706300)。
文摘The textile industry,while creating material wealth,also exerts a significant impact on the environment.Particularly in the textile manufacturing phase,which is the most energy-intensive phase throughout the product lifecycle,the problem of high energy usage is increasingly notable.Nevertheless,current analyses of carbon emissions in textile manufacturing emphasize the dynamic temporal characteristics while failing to adequately consider critical information such as material flows and energy consumption.A carbon emission analysis method based on a holographic process model(HPM)is proposed to address these issues.First,the system boundary in the textile manufacturing is defined,and the characteristics of carbon emissions are analyzed.Next,an HPM based on the object-centric Petri net(OCPN)is constructed,and simulation experiments are conducted on three different scenarios in the textile manufacturing.Subsequently,the constructed HPM is utilized to achieve a multi-perspective analysis of carbon emissions.Finally,the feasibility of the method is verified by using the production data of pure cotton products from a certain textile manufacturing enterprise.The results indicate that this method can analyze the impact of various factors on the carbon emissions of pure cotton product production,and by applying targeted optimization strategies,carbon emissions have been reduced by nearly 20%.This contributes to propelling the textile manufacturing industry toward sustainable development.
