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深成侵入岩类不平衡岩石图像数据集PlutonicRocks-13
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作者 陈忠良 胡召齐 郑超杰 《中国科学数据(中英文网络版)》 2026年第1期3-18,共16页
岩性识别是地质工作者的基本技能之一。随着人工智能的兴起,如何把地质专业人员识别岩性的能力转化成人工智能模型,提供岩性智能识别服务,让地学爱好者或者非地质专业人员也能较准确地识别岩性,成为地学领域智能服务需求之一。自然条件... 岩性识别是地质工作者的基本技能之一。随着人工智能的兴起,如何把地质专业人员识别岩性的能力转化成人工智能模型,提供岩性智能识别服务,让地学爱好者或者非地质专业人员也能较准确地识别岩性,成为地学领域智能服务需求之一。自然条件下,由于地表岩石分布不均,岩石图像数据集属于典型的长尾分布。本研究以深成侵入岩为例,选择于炳松等主编的《岩石学》中的岩石分类和命名方案,构建类不平衡的岩石图像识别研究数据集PlutonicRocks-13。本数据集包含13种常见的深成侵入岩,共4785张图片,原始图像共2.49 GB,主要岩石类型包括橄榄岩、辉石岩、角闪石岩、辉长岩、闪长岩、二长岩、正长岩、霞石正长岩、花岗闪长岩、二长花岗岩、正长花岗岩、斜长花岗岩、文象花岗岩。岩石图像主要从野外和馆藏机构采集露头和手标本图像,辅以网络渠道收集。经过筛选、处理和标注后,图像最终形成能为岩石图像分类任务提供基础数据的数据集。同时,采用岩石薄片鉴定和基于深度学习可解释性分析的数据集偏见检测等方法开展数据标注质量控制和评估。采用标注标签转换为问答对的方式,还可构建面向岩石图像分类任务的微调指令,为多模态模型的岩石图像分类任务提供指令微调数据集。本图像数据集可为岩石图像自动识别研究提供可靠的数据支撑,对地质调查、地表基质调查和地质科普等有重要的参考价值。 展开更多
关键词 岩浆岩 侵入岩 长尾分布 类不平衡 图像分类
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Zircon U-Pb ages of the volcanic rocks and their constraints on the ending of the Huoshiling Formation in the southeastern of Songliao Basin,NE China 被引量:1
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作者 Xue-jiao Qu Ming-kai Zhang +5 位作者 Pu-jun Wang Zhuo-long Yang You-feng Gao Kang-jun Wu Jia Wang Xian-feng Tan 《China Geology》 2026年第1期214-216,I0023,共4页
1.Objective The Songliao Basin(SB)is situated on the eastern margin of Eurasia continent(Northeast Asia).During the Late Jurassic to Early Cretaceous,hundreds of rifting basins developed in this area,and the SB is a u... 1.Objective The Songliao Basin(SB)is situated on the eastern margin of Eurasia continent(Northeast Asia).During the Late Jurassic to Early Cretaceous,hundreds of rifting basins developed in this area,and the SB is a unique case among them as it evolved into the largest rift basin.The rift basin filling of SB includes Huoshiling Formation,Shahezi Formation,and Yingcheng Formation in ascending order.The mega-rifting was controlled by the Mongol-Okhotsk Collisional Belt to the north and northwest and the Pacific Subduction Zone to the east(Wang PJ et al.,2016).As the first rifting succession,the Huoshiling Formation contains key information about the formation of the rifting basins and records the evolution of the Mongol-Okhotsk Collisional Belt and the Pacific Subduction Zone.However,the geological period of the Huoshiling Formation has not been well constrained for two main reasons.First,it is easily confused with the Yingcheng Formation,as both are dominated by volcanogenic-sedimentary successions.Second,there is lack of reliable dating samples from the uppermost part of the Huoshiling Formation due to its considerable burial depth. 展开更多
关键词 rift basin rift basinthe yingcheng formation ZIRCON U Pb ages rifting basins volcanic rocks huoshiling formationshahezi formationand
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Petrogenesis and tectonic significance of the Paleoproterozoic Chibaisong meta-mafic rocks in the northeastern Jiao-Liao-Ji Belt
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作者 ZHANG Jirui YU Hongchao +2 位作者 LIU Jin ZHANG Hongxiang ZHANG Yuanzhuhui 《Global Geology》 2026年第1期68-85,共18页
The Jiao-Liao-Ji Belt within the North China Craton had undergone a complex tectonic evolution,marked by extensive Paleoproterozoic magmatism that produced a diverse range of mafic to felsic magmatic rocks.These event... The Jiao-Liao-Ji Belt within the North China Craton had undergone a complex tectonic evolution,marked by extensive Paleoproterozoic magmatism that produced a diverse range of mafic to felsic magmatic rocks.These events provide valuable geological records for understanding the tectonic evolution of the Jiao-Liao-Ji Belt.This study focuses on the Paleoproterozoic Chibaisong meta-gabbro in southern Jilin,investigating the source of mafic magma,petrogenesis,and tectonic setting through systematic petrological analysis,zircon U-Pb dating,and geochemical studies.The findings contribute to constraining the dynamic mechanisms of Paleoproterozoic extensional rifting in the Jiao-Liao-Ji orogenic belt.Geochemical data indicate that the samples exhibit low SiO₂(47.99–50.66 wt.%),TiO₂(0.75–3.20 wt.%),Nb(3.22–8.09 ppm),and Ta(0.22–0.51 ppm)contents,along with high TFeO₃(11.97–15.82 wt.%)and MgO(5.67–12.66 wt.%)concentrations.They also show low Nb/La ratios and high(Th/Nb)N values,consistent with the geochemical characteristics of tholeiitic basalts.The samples display low total rare earth element concentrations,weak or absent Eu anomalies,slight enrichment in light rare earth elements,relatively flat heavy rare earth element patterns,and depletion in Nb,Ta,and Ti.The meta-gabbro from southern Jilin exhibits geochemical similarities to Paleoproterozoic metamafic rocks from other regions of the Jiao-Liao-Ji Belt,resembling enriched mid-ocean ridge basalts(E-MORB)with Nb,Ta,and Ti depletion.Integration of previous studies and geochemical data suggests that the 2.16–2.10 Ga metamafic rocks in the Jiao-Liao-Ji Belt experienced contamination by older crustal material.These results indicate that the 2.16–2.10 Ga metamafic rocks are unlikely to be associated with island arc,continental arc,or mid-ocean ridge settings.Instead,they are more likely related to intraplate magmatism associated with continental rifting. 展开更多
关键词 Jiao-Liao-Ji Belt North China Craton PALEOPROTEROZOIC southern Jilin region metamafic rocks
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Coupled TM-damage modeling and global sensitivity analysis of thermal spalling in heterogeneous rocks
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作者 Liyuan Liu Mingshan Shi +4 位作者 Derek Elsworth Tao Wang Hongguang Ji Le Zhang Yaohui Li 《International Journal of Mining Science and Technology》 2026年第3期535-552,共18页
Thermal spalling in heterogeneous rocks under rapid heating poses critical risks to deep mining and geothermal operations.In this study,we develop a coupled thermal-mechanical-damage(TM D)model that explicitly incorpo... Thermal spalling in heterogeneous rocks under rapid heating poses critical risks to deep mining and geothermal operations.In this study,we develop a coupled thermal-mechanical-damage(TM D)model that explicitly incorporates Weibull distributed heterogeneity to a single fracture in rock,and validate it against ceramic quenching and granite acoustic emission experiments.Distance based generalized sensitivity analysis(DGSA)is applied to quantify the influence and interactions of key parameters,revealing the dominant controls on spalling onset,severity,and damage morphology.The results demonstrate that thermal stress dominates crack initiation and propagation,that lateral constraints can significantly delay and suppress spalling,and that material heterogeneity markedly influences peak stress and damage modes within a certain range of thermal expansion coefficient and has multiple effects on thermal spalling.This study provides a theoretical basis for quantitative assessment and parameter optimization of thermal spalling processes in rock masses. 展开更多
关键词 rock heterogeneity Thermal spalling Microstructure evolution Sensitivity analysis Parameter interaction effect
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Rock strength assessment in tectonically deformed calcareous rocks integrating equotip,ultrasound velocity,and geo-structural fracture analysis
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作者 Elisa Mammoliti Danica Jablonská +3 位作者 Antonio Ferretti Michele Morici Stefano Mazzoli Mirko Francioni 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期196-213,共18页
In complex geological environments,the analysis of drill cores to determine rock strength can be challenging due to the wide variability in the degree of fracturing,leading to subjectivity in the collection of represe... In complex geological environments,the analysis of drill cores to determine rock strength can be challenging due to the wide variability in the degree of fracturing,leading to subjectivity in the collection of representative samples for uniaxial compressive strength testing.This study evaluates non-destructive techniques on calcareous rocks with different tectonic deformations,including Equotip hardness,ultrasound P-wave velocity,thin section analysis,and calcimetry,integrated with photogrammetric fracture analysis.The investigated carbonate rock samples are sourced from drill cores derived from the Umbria-Marche fold and thrust belt(northern Apennines,Italy),including a gently dipping limb of an anticline,a hinge zone of an anticline,and a fault zone associated with a thrust.Fracture intensity,quantified by the P21 parameter using photogrammetric techniques on pre-loading rock samples,is assessed alongside macroscopic identification of discontinuities(such as stylolites,veins,and joints)using marker colours to monitor failures during uniaxial compression testing.Empirical correlations depicted by single and multi-linear relationships indicate a strong dependence between the mechanical and physical properties of limestones.Both Equotip and P-wave velocity are influenced by fracture intensity,but P-wave velocity varies significantly with discontinuity orientation,especially at 45°-90°.To refine uniaxial compressive strength predictions and mitigate multicollinearity,statistical approaches,including linear and multilinear regression,Principal Component Analysis and Gaussian Process Regression,were tested.Findings improve the reliability of non-destructive techniques for assessing rock strength in structurally complex settings,with implications for geotechnical applications. 展开更多
关键词 Non-destructive testing Uniaxial compressive strength Equotip Ultrasound pulse velocity FRACTURING Calcareous rocks
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Characterization of the permeability evolution of hard and soft rocks under hydro-mechanical coupling conditions
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作者 Zhen Huang Jian Yu +4 位作者 Yun Wu Cong Gong Xiaozhao Li Kui Zhao Dickson Moyo 《Deep Underground Science and Engineering》 2026年第1期220-232,共13页
Prediction of permeability changes in surrounding rock induced by engineering disturbances is crucial for mitigating tunnel water inrush accidents.This study investigates the progressive failure characteristics and pe... Prediction of permeability changes in surrounding rock induced by engineering disturbances is crucial for mitigating tunnel water inrush accidents.This study investigates the progressive failure characteristics and permeability evolution of hard and soft rocks subjected to triaxial compression.A series of laboratory tests were conducted at confining pressures ranging from 4 to 20 MPa.Experimental results demonstrate that rock permeability variation with strain shows three distinct stages:an initial decrease,a stage of rapid mutation,and a postpeak increase.The concept of critical permeability barrier strength is introduced,representing the stress level at which continuous fracture formation enables significant seepage.Furthermore,two generalized permeability–stress models are developed for soft and hard rocks.The predicted permeability values obtained from these models align well with the experimental data.These findings offer valuable insights into the hydro-mechanical coupling behavior of rocks,providing a foundation for safe construction practices in underground engineering. 展开更多
关键词 hydro-mechanical coupling mathematical model permeability evolution soft and hard rocks water inrush
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Exploring the thermal evolution of highly-to over-mature source rocks using Raman spectroscopy and geochemical signatures
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作者 Fu-hua Shang Xiao-peng Sun +3 位作者 Shu-wei Ma Yu-tong Pang Guan-qun Zhou Ke Miao 《China Geology》 2026年第1期75-85,共11页
This study investigated the heterogeneous responses of organic matter(OM)in highly-to over-mature source rocks during thermal maturation.An integrated analysis was conducted on the Raman spectroscopic and geochemical ... This study investigated the heterogeneous responses of organic matter(OM)in highly-to over-mature source rocks during thermal maturation.An integrated analysis was conducted on the Raman spectroscopic and geochemical signatures of shales from the Lower Silurian Longmaxi Formation and the Lower Cambrian Qiongzhusi Formation,as well as anthracites from the Lower Permian Shanxi–Formation and the Upper Carboniferous Taiyuan Formation(collectively referred to as the Shanxi Taiyuan Formations).Additionally,burial and thermal evolution modeling was employed to support the analysis.A systematic assessment of Raman spectral parameters(e.g.,the positions and intensity ratio of the D and G bands)revealed robust correlations between the thermal history patterns of source rocks and molecular structural evolution parameters.The subsequent mechanistic quantification demonstrated that the maturation state of the source rocks was subjected to the hierarchical control of three principal factors:Peak heating temperature,the duration of sustained thermal intensity,and effective maturation duration.In addition,comparative analyses demonstrated that the anthracites attained higher structural ordering under sustained thermal conditions.This contrasts with the disordered carbon matrices observed in the intermittently heated shales.Raman spectroscopy further revealed broader variations in the D and G band intensities of the Longmaxi Formation compared to the Qiongzhusi Formation.This difference is associated with their different thermal histories.The thermal burial histories confirm that shales in the Longmaxi Formation underwent thermal exposure at lower peak temperatures over a shorter duration compared to those in the Qiongzhusi Formation.Finally,this study established a maturity calibration model for over-mature source rocks through a systematic correlation between Raman peak height ratios(R_(D/G))and vitrinite reflectance(R_(o)). 展开更多
关键词 Raman spectroscopy Overmature source rock Qiongzhusi Formation Longmaxi Formation ANTHRACITE Mineral exploration engineering
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Review of the classification and related terminology of fine-grained sedimentary rocks
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作者 ZHU Rukai SUN Longde +2 位作者 ZOU Caineng CHEN Yang MIAO Xue 《Petroleum Exploration and Development》 2026年第1期61-78,共18页
Through tracing the background and customary usage of classification of fine-grained sedimentary rocks and terminology,and comparing current“sedimentary petrology”textbooks and monographs,this paper proposes a class... Through tracing the background and customary usage of classification of fine-grained sedimentary rocks and terminology,and comparing current“sedimentary petrology”textbooks and monographs,this paper proposes a classification scheme for fine-grained sedimentary rocks and clarifies related terminology.The comprehensive analysis indicates that the classification of clastic rocks,volcanic clastic rocks,chemical rocks,and biogenic(carbonate)rocks is unified,and the definitions of terms such as lamination,bedding and beds are consistent.However,there is a disagreement on the definition of“mud”.European and American scholars commonly use the term“mud”to include silt and clay(particle size less than 0.0625 mm).Chinese scholars equate the term“mud”to“clay”(particle size less than 0.0039 mm or less than 0.01 mm).Combined with the discussion on terms such as sedimentary structures(bedding,lamination and lamellation),shale,mudstone,mudrocks/argillaceous rocks and mud shale,it is recommended to use“fine-grained sedimentary rocks”as the general term for all sedimentary rocks composed of fine-grained materials with particle size less than 0.0625 mm,including claystone/mudrocks and siltstone.Claystone/mudrocks are further classified into argillaceous(or clayey)mudstone/shale,calcareous mudstone/shale,siliceous mudstone/shale,silty mudstone/shale and silt-containing mudstone/shale.Argillaceous(or clayey)mudstone/shale emphasizes a content of clay minerals or clay-sized particles exceeding 50%.Other mudstones/shales emphasize a content of particles(particle size less than 0.0625 mm)exceeding 50%.The commonly referred term“shale”should not include siltstone.It is necessary to establish a reasonable,standardized,and applicable classification scheme for fine-grained sedimentary rocks in the future.An integrated shale microfacies research at the thin-section scale should be carried out,and combined with well logging data interpretation and seismic attribute analysis,a geological model of lithology/lithofacies will be iteratively upgraded to accurately determine sweet layer,locate target layer,and evaluate favorable area. 展开更多
关键词 fine-grained sedimentary rock SHALE MUDSTONE clay shale oil shale gas lamellation shale microfacies classification scheme fine-grained sedimentology
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Mechanical behaviors and instability of rocks subjected to hydraulic progressive wetting:Acoustic emission and uniaxial compression experiments
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作者 Yixin Liu Jiaxin Cheng +2 位作者 Chuanhua Xu Gang Wang Jiang Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期593-610,共18页
In the field of rock engineering,the influence of water is a dynamic process that exhibits varying effects over time and across different locations.To further understand how water influences the mechanical properties ... In the field of rock engineering,the influence of water is a dynamic process that exhibits varying effects over time and across different locations.To further understand how water influences the mechanical properties and acoustic emission(AE)behavior of rocks,this study conducted uniaxial compression experiments on sandstones with varying degrees of wetting under both natural conditions and water-chemical environments.In addition,the study combined AE equipment with digital image correlation(DIC)to monitor the entire failure process.Using the sliding window algorithm,the variation in the variance of AE characteristic parameters during the process of sandstone loading to failure is analyzed from the perspective of critical slowing down.This analysis enables the effective identification of the early warning signal before failure.The experimental findings suggest that an increase in wetting height results in a gradual decrease in peak stress,accompanied by a concomitant increase in the percentage of shear cracks.The characteristic parameters,including energy,amplitude,and ringing count,all exhibit critical slowing phenomena.The waveform of AE characteristic parameters of the same sample is similar,and the mutation time of the precursor signal is roughly the same.All signals appear in the irreversible plastic deformation stage of microcrack initiation.The integration of critical slowing down theory and the b-value early warning method facilitates a more comprehensive evaluation of the stability of rock mass,thereby significantly enhancing the efficiency and safety of disaster prevention measures. 展开更多
关键词 rock wetting and softening Uniaxial compression Acoustic emission(AE) Critical slowing Monitoring and early warning
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A comparative study on the apatite and zircon from the ore-related and-barren magmatic rocks of the Shatanjiao region,Lower Yangtze River Belt:Controlling effects for petrogenesis and Cu-Au mineralization
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作者 Yu Wang Jing-ya Cao +4 位作者 Sheng-xiong Yang Xiao-yong Yang Majid Ghasemi Siani Asghar Dolati Muhammad Hafeez 《China Geology》 2026年第1期120-135,I0015-I0022,共24页
The links between the adakitic rocks and Cu-Au mineralization have long been argued.This study investigates petrogenesis and its link to mineralization potential by a series of in-situ geochronological and geochemical... The links between the adakitic rocks and Cu-Au mineralization have long been argued.This study investigates petrogenesis and its link to mineralization potential by a series of in-situ geochronological and geochemical signatures of apatite and zircon in three ore-related intrusions and one-barren intrusion in the Middle-Lower Yangtze River Metallogenic Belt(MLYRB).Zircon U-Pb dating yield ages of 139–143 Ma and 121 Ma for the ore-related and ore-barren intrusions,respectively.The ore-related rocks have higher apatite Sr/Y(1.57–9.69),(La/Yb)_(N)(16.7–159.5),andδEu(0.45–0.74)than the ore-barren rocks of 0.57–1.02,19.3–24.1 and 0.40–0.45,respectively,indicating the former has an adakitic affinity,while the latter has a non-adakitic affinity.The ore-related rocks have enriched zircon Hf isotopes withε_(Hf)(t)values of-15.9 to-5.5 and T_(DMC)ages of 2408–1655 Ma and apatite Sr-Nd isotopes,indicating that the ore-related magmas were mainly originated from partial melting of subducted oceanic crust.The orebarren rocks have higherε_(Hf)(t)values of-6.6 to-4.6 and lower T_(DMC)ages of 1598–1469 Ma and apatite Sr-Nd isotopes,indicating a lithospheric mantle source.The ore-related rocks have higher oxygen fugacity of mean∆FMQ+2.00 and X_(F)/X_(OH)of 8.36–175 than the ore-barren rocks of mean∆FMQ+1.43 and3.72–4.96.It was inferred that magma source,water content,and oxygen fugacity emerge as critical factors governing the regional Cu-Au mineralization potential. 展开更多
关键词 Sr-Nd-Hf isotopes Zircon U-Pb dating Apatite Sr-Nd isotopes Oxygen fugacity Magma source Adakitic rocks Cu-Au mineralization Shatanjiao Orefield
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血根碱调节RhoA/ROCK信号通路对糖尿病性骨质疏松症大鼠骨代谢和炎性损伤的影响
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作者 周飞 易松 +1 位作者 岳建彪 张上上 《免疫学杂志》 2026年第2期81-86,共6页
目的探究血根碱调节Ras同源基因家族成员A(RhoA)/Rho相关激酶(ROCK)信号通路对糖尿病性骨质疏松症大鼠骨代谢和炎性损伤的影响。方法取60只健康雄性8周龄SD大鼠,分为正常组(未予任何处理)、模型组(腹腔注射60 mg/kg 0.2%链脲佐菌素+骨... 目的探究血根碱调节Ras同源基因家族成员A(RhoA)/Rho相关激酶(ROCK)信号通路对糖尿病性骨质疏松症大鼠骨代谢和炎性损伤的影响。方法取60只健康雄性8周龄SD大鼠,分为正常组(未予任何处理)、模型组(腹腔注射60 mg/kg 0.2%链脲佐菌素+骨密度降低)、低剂量血根碱组(L-血根碱组)、高剂量血根碱组(H-血根碱组)、H-血根碱+抑制剂组,每组12只,L-血根碱组、H-血根碱组和H-血根碱+抑制剂组分别为造模成功大鼠予2.50 mg/(kg·d)血根碱灌胃+等量0.9%氯化钠注射液腹腔注射、6.25 mg/(kg·d)血根碱灌胃+等量0.9%氯化钠注射液腹腔注射、6.25 mg/(kg·d)血根碱灌胃+40 mg/(kg·d)Rhosin腹腔注射。各组大鼠处理8周后,使用双能X线吸收测定扫描系统测量骨密度;检测血清钙、骨钙素(OC)、骨保护素(OPG)、碱性磷酸酶(ALP)水平;行生物力学测试检测各组大鼠股骨最大载荷;HE染色观察各组大鼠胰腺组织病理学变化与股骨组织形态学;酶联免疫吸附试验检测各组大鼠血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平;Western blot实验检测各组大鼠股骨组织RhoA、ROCK1和ROCK2蛋白表达。结果与正常组相比,模型组大鼠骨密度和股骨最大载荷降低,胰岛和股骨组织被破坏,血清钙、OC、OPG含量及股骨组织RhoA、ROCK1、ROCK2蛋白表达降低,血清ALP、IL-1β、TNF-α、IL-6水平升高(P<0.05);与模型组相比,L-血根碱组、H-血根碱组大鼠骨密度和股骨最大载荷升高,胰岛和股骨组织损伤减轻,血清钙、OC、OPG含量及股骨组织RhoA、ROCK1、ROCK2蛋白表达升高,血清ALP、IL-1β、TNF-α、IL-6水平降低,且H-血根碱组上述指标变化更显著(P<0.05);与H-血根碱组相比,H-血根碱+抑制剂组逆转了血根碱对大鼠骨代谢和炎性损伤的影响。结论血根碱通过激活RhoA/ROCK信号通路改善糖尿病性骨质疏松症大鼠骨代谢,并减轻了其炎性损伤。 展开更多
关键词 骨质疏松症 糖尿病性 血根碱 大鼠 RhoA/rock信号通路 骨代谢 炎性损伤
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RhoA/ROCK信号通路在椎间盘退变中的作用
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作者 杜健强 郭子煜 +3 位作者 姚晨阳 冯其金 古恩鹏 王琳珏 《生理科学进展》 北大核心 2026年第1期52-59,共8页
椎间盘由髓核、纤维环和软骨终板组成,对维持脊柱正常生理功能至关重要。椎间盘退变(intervertebral disc degeneration,IDD)是导致腰背痛等脊柱退行性疾病的主要病理基础,给人们的健康状况造成极大的困扰。然而目前对IDD的分子机制仍... 椎间盘由髓核、纤维环和软骨终板组成,对维持脊柱正常生理功能至关重要。椎间盘退变(intervertebral disc degeneration,IDD)是导致腰背痛等脊柱退行性疾病的主要病理基础,给人们的健康状况造成极大的困扰。然而目前对IDD的分子机制仍然缺乏清晰的了解,导致缺乏有效的靶向干预措施。RAS同源家族成员A(RAS homolog family member A,RhoA)/Rho相关蛋白激酶(Rho-associated protein kinase,ROCK)信号通路是调节细胞收缩、迁移和生长的经典通路。其被激活后可参与调控细胞骨架重塑、细胞外基质代谢、生物钟节律、细胞表型改变、细胞衰老及死亡等环节,进而影响IDD的病理进程。深入探究RhoA/ROCK信号通路在IDD中的作用,不仅能揭示疾病发生的分子生物学机制,也有望为研发靶向该通路的治疗策略提供理论依据。 展开更多
关键词 椎间盘退变 RhoA/rock 信号传导 作用机制
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温阳利水方通过激活RhoA/ROCK通路改善慢性肺源性心脏病小鼠心肌细胞焦亡的机制
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作者 陈昕芳 李红 +2 位作者 苏士成 吴峰妹 黄辉 《辽宁中医杂志》 北大核心 2026年第2期204-208,F0003,共6页
目的探讨温阳利水方通过激活RhoA/ROCK通路改善慢性肺源性心脏病小鼠心肌细胞焦亡的机制。方法60只健康雄性C57BL/6小鼠用于实验研究。将小鼠暴露于烟雾和高压氧舱中诱导慢性肺源性心脏病(chronic pulmonary heart disease,CPHD)模型。... 目的探讨温阳利水方通过激活RhoA/ROCK通路改善慢性肺源性心脏病小鼠心肌细胞焦亡的机制。方法60只健康雄性C57BL/6小鼠用于实验研究。将小鼠暴露于烟雾和高压氧舱中诱导慢性肺源性心脏病(chronic pulmonary heart disease,CPHD)模型。将小鼠分为以下3组:对照组(正常条件下饲养的小鼠,接受清洁空气和0.9%氯化钠溶液作为模型组和温阳利水方组的对照,n=20),模型组(如前所述建立的CPF模型,n=20),温阳利水方组(在模型小鼠的基础上给予温阳利水方药剂治疗,n=20)。通过qPCR分析RhoA、ROCK1和ROCK2 mRNA表达。通过蛋白质印迹分析小鼠心肌组织p-MBS/t-MBS比值。通过酶联免疫吸附测定(ELISA)检测小鼠外周血炎症因子肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素1β(interleukin-1β,IL-1β)和白细胞介素6(interleukin-6,IL-6)水平。组织学分析小鼠心肌受损情况。通过超声心动图检测小鼠心肌功能。通过PI染色检测焦亡细胞。通过蛋白质印迹分析焦亡相关因子高迁移率族蛋白(HMGB1)和热休克蛋白70(HSP70)的表达。结果模型组RhoA、ROCK1和ROCK2 mRNA表达较对照组升高(P<0.05),温阳利水方组RhoA、ROCK1和ROCK2 mRNA表达较模型组降低(P<0.05)。模型组p-MBS/t-MBS比值较对照组升高(P<0.05),温阳利水方组p-MBS/t-MBS比值较模型组降低(P<0.05)。模型组TNF-α、IL-1β和IL-6水平较对照组升高(P<0.05),温阳利水方组TNF-α、IL-1β和IL-6水平较模型组降低(P<0.05)。HE染色显示,与对照组小鼠心肌相比,模型组小鼠心肌细胞排列紊乱,细胞肥大,炎症细胞浸润明显(P<0.05),与模型组相比,温阳利水方显著改善了CPHD引起的病理改变(P<0.05)。马松染色作为纤维化的病理检查表明,CPHD可导致小鼠严重的心肌纤维化,温阳利水方治疗可显著减少胶原沉积(P<0.05)。模型组小鼠左室收缩压(left ventricular systolic pressure,LVSP)、左室射血分数(left ventricular ejection fraction,LVEF)和心搏量(stroke volume,SV)较对照组降低(P<0.05),温阳利水方组LVSP、LVEF和SV较模型组升高(P<0.05)。模型组小鼠心肌细胞焦亡率较对照组升高(P<0.05),温阳利水方组小鼠心肌细胞焦亡率较模型组降低(P<0.05)。模型组HMGB1和HSP70的表达较对照组升高(P<0.05),温阳利水方组HMGB1和HSP70的蛋白表达较模型组降低(P<0.05)。结论温阳利水方通过激活RhoA/ROCK通路,显著改善了CPHD小鼠模型中心肌细胞焦亡和心肌结构及功能。 展开更多
关键词 温阳利水方 RhoA/rock CPHD 心肌细胞焦亡
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Assessing ground stability of a vertical backfilled stope considering creep behaviors of surrounding rocks 被引量:3
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作者 Ruofan Wang Lang Liu +4 位作者 Mengbo Zhu Huafu Qiu Bingbing Tu Huisheng Qu Hao Cui 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期187-199,共13页
Backfill is often employed in mining operations for ground support,with its positive impact on ground stability acknowledged in many underground mines.However,existing studies have predominantly focused only on the st... Backfill is often employed in mining operations for ground support,with its positive impact on ground stability acknowledged in many underground mines.However,existing studies have predominantly focused only on the stress development within the backfill material,leaving the influence of stope backfilling on stress distribution in surrounding rock mass and ground stability largely unexplored.Therefore,this paper presents numerical models in FLAC3D to investigate,for the first time,the time-dependent stress redistribution around a vertical backfilled stope and its implications on ground stability,considering the creep of surrounding rock mass.Using the Soft Soil constitutive model,the compressibility of backfill under large pressure was captured.It is found that the creep deformation of rock mass exercises compression on backfill and results in a less void ratio and increased modulus for fill material.The compacted backfill conversely influenced the stress distribution and ground stability of rock mass which was a combined effect of wall creep and compressibility of backfill.With the increase of time or/and creep deformation,the minimum principal stress in the rocks surrounding the backfilled stope increased towards the pre-mining stress state,while the deviatoric stress reduces leading to an increased factor of safety and improved ground stability.This improvement effect of backfill on ground stability increased with the increase of mine depth and stope height,while it is also more pronounced for the narrow stope,the backfill with a smaller compression index,and the soft rocks with a smaller viscosity coefficient.Furthermore,the results emphasize the importance of minimizing empty time and backfilling extracted stope as soon as possible for ground control.Reduction of filling gap height enhances the local stability around the roof of stope. 展开更多
关键词 Ground stability Time dependency CREEP Surrounding rocks Backfilled stope
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Stress-sensitive porosity and permeability in carbonate rocks for underground hydrogen storage:A digital rock simulation study 被引量:1
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作者 Ziyi Pu Ye Tian +5 位作者 Jing Fu Yi Yang Ali Satea Zunrong Xiao Yulong Zhao Liehui Zhang 《International Journal of Coal Science & Technology》 2025年第4期90-105,共16页
Hydrogen,a genuinely clean energy,is a promising alternative to fossil fuels.Inspired by underground gas storage of methane,establishing underground hydrogen storage(UHS)in depleted oil and gas reservoirs has emerged ... Hydrogen,a genuinely clean energy,is a promising alternative to fossil fuels.Inspired by underground gas storage of methane,establishing underground hydrogen storage(UHS)in depleted oil and gas reservoirs has emerged as a significant research focus.Carbonate reservoirs,where widely-presented fractures can facilitate the high-speed injection and production of gases,are hence ideal candidates for building underground hydrogen storage facilities.During the cyclic injection and extraction processes of UHS,the formation is subjected to stress disturbances,leading to stress sensitivity.Understanding the stress sensitivity patterns of carbonate rocks is crucial for optimizing injection and production strategies.This study reconstructed three-dimensional digital models of fractured carbonate rocks from the L gas field using micro-CT scanning technology.Utilizing the finite element method,we investigated the microscopic permeability characteristics of carbonate rocks and analyzed the impact of stress loading direction and confining stress on stress sensitivity.The findings reveal that the stress loading direction significantly influences the stress sensitivity of fractured carbonate rocks.When a stress of 60 MPa is applied perpendicular to the fracture direction,the permeability reduction ratio can reach 17.32%.In contrast,when the same stress is applied parallel to the fracture direction,the permeability reduction ratio is only 4.82%.Furthermore,a simulation of UHS with cyclic injection and production of H2 in the target block was conducted.When both permeability and porosity stress sensitivity were considered,the working gas volume for UHS decreased by only 3.4%,demonstrating that fractured carbonate reservoirs are feasible candidates for constructing underground hydrogen storage. 展开更多
关键词 Underground hydrogen storage Digital rock Stress sensitivity CT scan Carbonate rock Simulation
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Restoration of hydrocarbon generation potential of the highly mature Lower Cambrian Yuertusi Formation source rocks in the Tarim Basin 被引量:2
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作者 Yao Hu Cheng-Zao Jia +6 位作者 Jun-Qing Chen Xiong-Qi Pang Lin Jiang Chen-Xi Wang Hui-Yi Xiao Cai-Jun Li Yu-Jie Jin 《Petroleum Science》 2025年第2期588-606,共19页
The Early Cambrian Yuertusi Formation(Є_(1)y)in the Tarim Basin of China deposits a continuously developed suite of organic-rich black mudstones,which constitute an important source of oil and gas reservoirs in the Pa... The Early Cambrian Yuertusi Formation(Є_(1)y)in the Tarim Basin of China deposits a continuously developed suite of organic-rich black mudstones,which constitute an important source of oil and gas reservoirs in the Paleozoic.However,its hydrocarbon generation and evolution characteristics and resource potential have long been constrained by deeply buried strata and previous research.In this paper,based on the newly obtained ultra-deep well drilling data,the hydrocarbon generation and expulsion model ofЄ_(1)y shale was established by using data-driven Monte Carlo simulation,upon which the hydrocarbon generation,expulsion,and retention amounts were calculated by using the diagenetic method.The research indicates that theЄ_(1)y shale reaches the hydrocarbon generation and expulsion threshold at equivalent vitrinite reflectances of 0.46%and 0.72%,respectively.The cumulative hydrocarbon generation is 68.88×10^(10)t,the cumulative hydrocarbon expulsion is 35.59×10^(10)t,and the cumulative residual hydrocarbon is 33.29×10^(10)t.This paper systematically and quantitatively calculates the hydrocarbon expulsion at various key geological periods for theЄ_(1)y source rocks in the study area for the first time,more precisely confirming that the black shale of theЄ_(1)y is the most significant source rock contributing to the marine oil and gas resources in the Tarim Basin,filling the gap in hydrocarbon expulsion calculation in the study area,and providing an important basis for the formation and distribution of Paleozoic hydrocarbon reservoirs.The prospect of deep ultra-deep oil and gas exploration in the Tarim Basin is promising.Especially,the large area of dolomite reservoirs under the Cambrian salt and source rock interiors are the key breakthrough targets for the next exploration in the Tarim Basin. 展开更多
关键词 Evaluation of resource potential Highly mature hydrocarbon source rocks Yuertusi formation Tarim Basin
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Coexisting Depleted and Enriched Mantle-derived Magmatic Rocks in the Liaodong Peninsula:Implications for the Destruction of the North China Craton 被引量:1
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作者 WANG Kun WANG Xingpeng +6 位作者 LAN Caiyun LIU Yali LIU Bin OU Quan MO Jiajian YANG Jialin MENG Fanwei 《Acta Geologica Sinica(English Edition)》 2025年第4期961-977,共17页
The North China Craton(NCC)experienced significant lithospheric thinning of over 100 km during the Mesozoic,accompanied by extensive magmatic activity and extensional tectonics.However,the timing and mechanism of this... The North China Craton(NCC)experienced significant lithospheric thinning of over 100 km during the Mesozoic,accompanied by extensive magmatic activity and extensional tectonics.However,the timing and mechanism of this thinning remain the subjects of debate.This study presents zircon U-Pb ages,Hf isotopic data and whole-rock elemental and Sr-Nd isotopic compositions of the Guanshui monzonites and diorites in the eastern NCC.Zircon U-Pb dating reveals that both rock types formed at ca.130 Ma.The monzonites,characterized by high Mg^(#)(50.9-57.9),low Nb/U ratios(2.53-3.89)and depleted isotopic compositions,suggest derivation from asthenospheric mantle modified by slab-derived fluids.The diorites,distinguished by low SiO_(2)(49.5-50.8),high Mg^(#)(66.7-68.5)and an EM2-type enriched mantle isotopic signature,point to a lithospheric mantle source modified by subducted sediment melts.The coexistence of monzonites and diorites suggests a transition in magma source from lithospheric to asthenospheric mantle,implying that lithospheric thinning may have commenced around 130 Ma.The destruction of the NCC was likely driven by localized,small-scale drip-style detachment processes,rather than wholesale lithospheric removal. 展开更多
关键词 lithospheric thinning magmatic rock mantle source North China Craton
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New progress and future exploration targets in petroleum geological research of ultra-deep clastic rocks in Kuqa Depression,Tarim Basin,NW China 被引量:4
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作者 WANG Qinghua YANG Haijun YANG Wei 《Petroleum Exploration and Development》 2025年第1期79-94,共16页
Significant exploration progress has been made in ultra-deep clastic rocks in the Kuqa Depression,Tarim Basin,over recent years.A new round of comprehensive geological research has formed four new understandings:(1)Es... Significant exploration progress has been made in ultra-deep clastic rocks in the Kuqa Depression,Tarim Basin,over recent years.A new round of comprehensive geological research has formed four new understandings:(1)Establish structural model consisting of multi-detachment composite,multi-stage structural superposition and multi-layer deformation.Multi-stage structural traps are overlapped vertically,and a series of structural traps are discovered in underlying ultra-deep layers.(2)Five sets of high-quality large-scale source rocks of three types of organic phases are developed in the Triassic and Jurassic systems,and forming a good combination of source-reservoir-cap rocks in ultra-deep layers with three sets of large-scale regional reservoir and cap rocks.(3)The formation of large oil and gas fields is controlled by four factors which are source,reservoir,cap rocks and fault.Based on the spatial configuration relationship of these four factors,a new three-dimensional reservoir formation model for ultra-deep clastic rocks in the Kuqa Depression has been established.(4)The next key exploration fields for ultra-deep clastic rocks in the Kuqa Depression include conventional and unconventional oil and gas.The conventional oil and gas fields include the deep multi-layer oil-gas accumulation zone in Kelasu,tight sandstone gas of Jurassic Ahe Formation in the northern structural zone,multi-target layer lithological oil and gas reservoirs in Zhongqiu–Dina structural zone,lithologic-stratigraphic and buried hill composite reservoirs in south slope and other favorable areas.Unconventional oil and gas fields include deep coal rock gas of Jurassic Kezilenuer and Yangxia formations,Triassic Tariqike Formation and Middle-Lower Jurassic and Upper Triassic continental shale gas.The achievements have important reference significance for enriching the theory of ultra-deep clastic rock oil and gas exploration and guiding the future oil and gas exploration deployment. 展开更多
关键词 Tarim Basin Kuqa Depression ultra-deep layers clastic rock multi-layer structural deformation multilayered migration and accumulation new three-dimensional accumulation model
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Pore-scale investigation of forced imbibition in porous rocks through interface curvature and pore topology analysis 被引量:1
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作者 Jianchao Cai Xiangjie Qin +2 位作者 Han Wang Yuxuan Xia Shuangmei Zou 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期245-257,共13页
Forced imbibition,the invasion of a wetting fluid into porous rocks,plays an important role in the effective exploitation of hydrocarbon resources and the geological sequestration of carbon dioxide.However,the interfa... Forced imbibition,the invasion of a wetting fluid into porous rocks,plays an important role in the effective exploitation of hydrocarbon resources and the geological sequestration of carbon dioxide.However,the interface dynamics influenced by complex topology commonly leads to non-wetting fluid trapping.Particularly,the underlying mechanisms under viscously unfavorable conditions remain unclear.This study employs a direct numerical simulation method to simulate forced imbibition through the reconstructed digital rocks of sandstone.The interface dynamics and fluid–fluid interactions are investigated through transient simulations,while the pore topology metrics are introduced to analyze the impact on steady-state residual fluid distribution obtained by a pseudo-transient scheme.The results show that the cooperative pore-filling process promoted by corner flow is dominant at low capillary numbers.This leads to unstable inlet pressure,mass flow,and interface curvature,which correspond to complicated interface dynamics and higher residual fluid saturation.During forced imbibition,the interface curvature gradually increases,with the pore-filling mechanisms involving the cooperation of main terminal meniscus movement and arc menisci filling.Complex topology with small diameter pores may result in the destabilization of interface curvature.The residual fluid saturation is negatively correlated with porosity and pore throat size,and positively correlated with tortuosity and aspect ratio.A large mean coordination number characterizing global connectivity promotes imbibition.However,high connectivity characterized by the standardized Euler number corresponding to small pores is associated with a high probability of non-wetting fluid trapping. 展开更多
关键词 Forced imbibition Porous rocks Interface dynamics Pore topology Residual fluid distribution
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Experimental study on failure precursory characteristics and moisture content effect of pre-cracked rocks under graded cyclic loading and unloading 被引量:1
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作者 Wei Zhang Dongxiao Zhang +1 位作者 Weiyao Guo Baoliang Zhang 《International Journal of Mining Science and Technology》 2025年第2期249-264,共16页
It is important to analyze the damage evolution process of surrounding rock under different water content for the stability of engineering rock mass.Based on digital speckle correlation(DSCM),acoustic emission(AE)and ... It is important to analyze the damage evolution process of surrounding rock under different water content for the stability of engineering rock mass.Based on digital speckle correlation(DSCM),acoustic emission(AE)and electromagnetic radiation(EMR),uniaxial hierarchical cyclic loading and unloading tests were carried out on sandstones with different fracture numbers under dry,natural and saturated water content,to explore the fracture propagation,failure precursor characteristics and damage response mechanism under the influence of water content effect.The results show that with the increase of water content,the peak stress and crack initiation stress decrease gradually,and the decreases are 15.28%-21.11%and 17.64%-23.04%,respectively.The peak strain and crack initiation strain increase gradually,and the increases are 19.85%-44.53%and 19.15%-41.94%,respectively.The precracked rock with different water content is mainly characterized by tensile failure at different loading stages.However,with the increase of water content,the proportion of shear cracks gradually increases,while acoustic emission events gradually decrease,the dissipative energy and energy storage limits of the rock under peak load gradually decrease,and the charge signal increases significantly,which is because the lubrication effect of water reduces the friction coefficient between crack surfaces. 展开更多
关键词 Damage mechanisms Pre-cracked rocks Crack propagation Water-rock interaction Graded cyclic loading and unloading
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