Engineering a versatile nanoplatform integrating imaging and therapeutic functions for efficient cancer treatment remains a grand challenge.Herein,a type of metal–organic framework(MOF)-based hybrid material for fluo...Engineering a versatile nanoplatform integrating imaging and therapeutic functions for efficient cancer treatment remains a grand challenge.Herein,a type of metal–organic framework(MOF)-based hybrid material for fluorescence imaging-guided synergistic phototherapy was prepared by in situ polymerization of a pyrrole(Py)monomer in the pores of a porphyrinic MOF.The resultant material(named PPy@MOF-525@HA)has a suitable size for cellular uptake,high degree of thermal stability and efficient photothermal conversion ability(η=62.1%)upon near-infrared light irradiation,showing great potential for photothermal therapy.In addition,the porphyrinic MOF can trigger the generation of singlet oxygen(^(1)O_(2))under the irradiation of visible light giving in vitro photodynamic therapy outcomes.Simultaneously,PPy@MOF-525@HA can also act as a contrast agent for cancer cell-specific targeting and fluorescence imaging to provide accurate guidance for cancer treatment.This work provides a promising platform for fluorescence imaging-guided synergistic phototherapy.展开更多
基金supported by a grant from the National Natural Science Foundation of China(22171001 and 21701160)the Doctor Startup Fund(S020118002/026)the Natural Science Foundation of Anhui Province of China(2108085MB49 and 1908085MB30).
文摘Engineering a versatile nanoplatform integrating imaging and therapeutic functions for efficient cancer treatment remains a grand challenge.Herein,a type of metal–organic framework(MOF)-based hybrid material for fluorescence imaging-guided synergistic phototherapy was prepared by in situ polymerization of a pyrrole(Py)monomer in the pores of a porphyrinic MOF.The resultant material(named PPy@MOF-525@HA)has a suitable size for cellular uptake,high degree of thermal stability and efficient photothermal conversion ability(η=62.1%)upon near-infrared light irradiation,showing great potential for photothermal therapy.In addition,the porphyrinic MOF can trigger the generation of singlet oxygen(^(1)O_(2))under the irradiation of visible light giving in vitro photodynamic therapy outcomes.Simultaneously,PPy@MOF-525@HA can also act as a contrast agent for cancer cell-specific targeting and fluorescence imaging to provide accurate guidance for cancer treatment.This work provides a promising platform for fluorescence imaging-guided synergistic phototherapy.
