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Digital Economy Development,Institutional Quality and Upstreamness of Global Value Chains
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作者 QI Junyan REN Yida 《Frontiers of Economics in China-Selected Publications from Chinese Universities》 2022年第1期24-57,共34页
By building a composite index for measuring national digital economy development and sectoral digital intensities,this paper derives metrics of industry-level digital economy penetration under the framework of special... By building a composite index for measuring national digital economy development and sectoral digital intensities,this paper derives metrics of industry-level digital economy penetration under the framework of specialization within global value chains(GVCs),systematically analyzes the mechanisms through which digital economy development affects GVCs upstreamness,and examines the moderating effect of institutional quality.The study shows that different dimensions of digital economy development significantly boost GVCs upstreamness,a conclusion that holds even after accounting for endogeneity through dynamic panel models with instrumental variables based on past data.Further research shows that technological innovation capabilities and resource allocation efficiency have gradually become important channels for digital economy development to boost GVCs upstreamness.Adding indicators on institutional quality reveals that greater institutional quality not only directly promotes GVCs upstreamness but also reinforces the impact of digital economy development on higher GVCs positioning. 展开更多
关键词 digital economy global value chains(GVCs) industry upstreamness institutional quality
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Hydrological Regime Variability between the Tien and Hau Rivers under the Impact of Anthropogenic Activities and Climate Change
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作者 Nguyen Dam Quoc Huy Tran Thi Kim Dang Truong An 《Journal of Environmental & Earth Sciences》 2025年第5期96-107,共12页
The distribution of flow discharge between the Tien and Hau Rivers in the Vietnamese Mekong Delta(VMD)plays an important role in Vietnam’s agricultural and aquaculture production activities.However,recent variations ... The distribution of flow discharge between the Tien and Hau Rivers in the Vietnamese Mekong Delta(VMD)plays an important role in Vietnam’s agricultural and aquaculture production activities.However,recent variations in water levels and flow patterns,driven by both human activities and climate change(CC),have posed significant challenges for water resource management.This study evaluates the impacts of unsustainable exploitation and CC on the hydrological regime of the Tien and Hau Rivers using non-parametric statistical methods.Long-term water level data(1978–2023)from Tan Chau,Chau Doc,and Vam Nao observation stations were analyzed using the Mann-Kendall test(MK),Sen’s Slope(SS)estimator,and Pettitt’s test to detect trends,quantify change magnitudes,and identify abrupt shifts.The results indicate a significant decline in flood-season water levels,with annual decrease rates ranging from 41.5 to 72.9 mm in September and November.Conversely,a slight increasing trend in water levels was observed in the dry season(DS)during the studied time.Additionally,findings reveal that the upstream Tien River exerts greater control over the hydrological regime in the Vam Nao River.These insights contribute to disaster risk assessment,sustainable water resource planning,and ecological risk evaluation.Furthermore,the results contribute to providing a foundation for applying hydrological and hydraulic models to forecast hydrodynamics,thereby supporting effective water management strategies and mitigating flood and dry risks in the VMD. 展开更多
关键词 Vietnamese Mekong Delta Water Flow Distribution Non-Parametric Tests UPSTREAM Vam Nao
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Numerical investigation of the transient process of a cover-plate pre-swirl system
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作者 Yifu LUO Qiang DU +3 位作者 Zengyan LIAN Guang LIU Lei XIE Qingzong XU 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 2025年第5期407-423,共17页
A pre-swirl system with a multi-chamber structure is crucial to the secondary air system of an aero engine.The airflow within the pre-swirl system(characterized by high-speed rotation and compressible flow)is complica... A pre-swirl system with a multi-chamber structure is crucial to the secondary air system of an aero engine.The airflow within the pre-swirl system(characterized by high-speed rotation and compressible flow)is complicated.During transient processes in aero engine operation,the pre-swirl system is subjected to upstream fluctuations,which is a less studied aspect.This paper delves into the unsteady flow characteristics within the pre-swirl system.We investigate the influence of different pressure-fluctuation boundary conditions,corresponding to step function,ramp function,and sine function,on the transient response characteristics of the pre-swirl system.The results indicate that the response characteristics are strongly affected by the upstream boundary conditions.An obvious overshoot phenomenon is observed in the actual temperature drop under the step and ramp function conditions.The peak time of the step function is 75%shorter compared to the ramp function.Furthermore,the flow parameters exhibit nonlinear growth during the transient process,emphasizing the need for consideration in future quasi-steady simulations.For the sine function condition,the pressure-fluctuation frequency minimally affects stable values of mass flow rate and actual temperature drop but exerts a substantial influence on the maximum deviation of actual temperature drop of the system.As the frequency increases from 100 Hz to 200 Hz,the maximum deviations for actual temperature drop change from around±13 K to±10 K. 展开更多
关键词 Upstream effect Unsteady flow Transient response Cover-plate cavity Pre-swirl system
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Deep-water Natural Gas Differential Migration and Enrichment in East African Transform Continental Marginal Basins
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作者 CAI Jun HE Youbin +1 位作者 LIANG Jianshe GUO Rong 《Acta Geologica Sinica(English Edition)》 2025年第4期1105-1118,共14页
Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysi... Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysis of the main source rocks,reservoirs,and vertical migration pathways within the Rovuma(RB)and Tanzania(TB)basins in East Africa utilizing drilling,logging,seismic,and geochemical data.The results indicate that the enhanced preservation conditions of the Lower Jurassic source rocks in the southwest could lead to the discovery of large natural gas fields in the southern TB and RB.The primary reservoir is a deep-water turbidite sandstone.Due to topographic differences,the expanse of the turbidite sandstones in the RB is significantly larger than those in Tanzania.The main vertical migration pathways are the western boundary fault zone of the Kerimbas Graben(WBFZ)and the Seagap fault zone(SFZ).In the RB,natural gas migrates vertically along the WBFZ and preferentially accumulates in the deep-water turbidite sandstones of the footwall under the control of the fluid potential.Conversely,in the southern TB,the deep natural gas first migrates upward along the SFZ,then moves along the shallow branch faults in the sandstones on both sides of the SFZ. 展开更多
关键词 upstream exploration natural gas differential enrichment transform continental marginal basin fault activity DEEP-WATER Mozambique-Tanzania
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The role of isolators in two-phase kerosene/air rotating detonation engines
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作者 Wenbo Cao Fang Wang +1 位作者 Chunsheng Weng Huangwei Zhang 《Defence Technology(防务技术)》 2025年第7期260-274,共15页
In this study, the three-dimensional non-premixed two-phase kerosene/air rotating detonation engines with different isolator configurations and throat area ratios are simulated by the Eulerian-Lagrangian method. The e... In this study, the three-dimensional non-premixed two-phase kerosene/air rotating detonation engines with different isolator configurations and throat area ratios are simulated by the Eulerian-Lagrangian method. The effects of the divergence, straight, and convergence isolators on the rotating detonation wave dynamics and the upstream oblique shock wave propagation mechanism are analyzed. The differences in the rotating detonation wave behaviors between ground and flight operations are clarified.The results indicate that the propagation regimes of the upstream oblique shock wave depend on the isolator configurations and operation conditions. With a divergence isolator, the airflow is accelerated throughout the isolator and divergence section, leading to a maximum Mach number(~1.8) before the normal shock. The total pressure loss reaches the largest, and the detonation pressure drops. The upstream oblique shock wave can be suppressed within the divergence section with the divergence isolator.However, for the straight and convergence isolators, the airflow in the isolator with a larger ψ_(1)(0.3 and0.4) can suffer from the disturbance of the upstream oblique shock wave. The critical incident angle is around 39° at ground operation conditions. The upstream oblique shock wave tends to be suppressed when the engine operates under flight operation conditions. The critical pressure ratio β_(cr0) is found to be able to help in distinguishing the propagation regimes of the upstream oblique shock wave. Slightly below or above the β_(cr0) can obtain different marginal propagation results. The high-speed airflow in the divergence section affects the fuel droplet penetration distance, which deteriorates the reactant mixing and the detonation area. Significant detonation velocity deficits are observed and the maximum velocity deficit reaches 26%. The results indicate the engine channel design should adopt different isolator configurations based on the purpose of total pressure loss or disturbance suppression. This study can provide useful guidance for the channel design of a more complete two-phase rotating detonation engine. 展开更多
关键词 Rotating detonation TWO-PHASE ISOLATOR Upstream oblique shock wave
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Moonward deviation of the solar wind
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作者 Chao Wei Hui Zhang +3 位作者 QuanMing Lu JunYi Ren XiaoWei Ma RunZe Li 《Earth and Planetary Physics》 2025年第6期1157-1162,共6页
The solar wind's interaction with the Moon has traditionally been understood through the Moon's absorption of solar wind particles and the formation of a plasma cavity on its nightside,known as the lunar wake.... The solar wind's interaction with the Moon has traditionally been understood through the Moon's absorption of solar wind particles and the formation of a plasma cavity on its nightside,known as the lunar wake.This study reveals unexpected,large-scale perturbations in the solar wind upstream of the Moon,using 11 years of data from the OMNI and ARTEMIS(Acceleration,Reconnection,Turbulence and Electrodynamics of Moon's Interaction with the Sun)missions(2012-2023).We find systematic moonward deviations of~tens of km/s in a direction perpendicular to the solar wind(moonward),at altitudes of up to 1000 km,particularly when the interplanetary magnetic field(IMF)lines are oblique to the solar wind(30°<θ<60°)and connected to the lunar dayside.The longer the duration of the interaction,the greater the moonward deviation.These perturbations can be explained by neither solar wind pickup of the reflected ions,nor lunar wake dynamics.Instead,they appear to correlate with magnetic connectivity between the ARTEMIS probes and the lunar surface,suggesting a more complex solar wind interaction than previously thought. 展开更多
关键词 plasma-moon interaction moonward deviation IMF connectivity lunar upstream perturbations
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Supply chain integrated merger and acquisitions(M&As)and firm energy performance
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作者 Fengxiang Zhao Bo Wang Mei Yu 《Chinese Journal of Population,Resources and Environment》 2025年第1期27-39,共13页
This paper examines the impact of upstream merger and acquisition(M&A)activities driven by supply chain integration motives on firm energy performance.By developing a microlevel theoretical framework,we examine th... This paper examines the impact of upstream merger and acquisition(M&A)activities driven by supply chain integration motives on firm energy performance.By developing a microlevel theoretical framework,we examine the intricate relationship between firms’upstream M&A strategies geared toward supply chain integration and their energy efficiency.We examine the impact of upstream M&A activities on energy performance using data from Chinese listed companies from 2007 to 2021.Our findings reveal that upstream M&A initiatives can enhance firms’energy efficiency,although there are discernible variations in the effects observed for M&A activities targeted downstream or within the same industry.By examining mechanisms,we elucidate the pivotal roles of input substitution effects and productivity enhancements through which upstream M&As boost energy performance.Furthermore,our analysis underscores the catalyzing impact of M&A activities in fostering collaborative innovation in green technologies among firms and suppliers,thus improving productivity and energy efficiency.We provide new microlevel evidence of the relationship between M&A transactions and corporate energy efficiency from upstream and downstream perspectives. 展开更多
关键词 Supply chain integration Upstream M&As Energy performance
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Experience,Challenges,and Development Trends of America’s“Natural Gas Independence”and Implications for the Upstream Development of Chinese Oil Companies
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作者 Hou Mingyang Zhang Xiao 《China Oil & Gas》 2025年第3期41-48,共8页
Since 2011,America has maintained its position as the world’s largest natural gas producer.Since 2017,America has consistently experienced a surplus in natural gas supply,becoming a net exporter of natural gas.Americ... Since 2011,America has maintained its position as the world’s largest natural gas producer.Since 2017,America has consistently experienced a surplus in natural gas supply,becoming a net exporter of natural gas.America’s“natural gas independence”has reshaped the global natural gas market,creating a new pattern of“supply shifting westward and consumption shifting eastward”. 展开更多
关键词 natural gas natural gasamerica s natural gas supply shifting westward consumption shifting eastward upstream development natural gas independence Chinese oil companies
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ADGAP:a user-friendly online ancient DNA database and genome analysis platform
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作者 Yanwei Chen Yu Xu +1 位作者 Kongyang Zhu Chuan-Chao Wang 《Journal of Genetics and Genomics》 2025年第8期1058-1061,共4页
The analysis of ancient genomics provides opportunities to explore human population history across both temporal and geographic dimensions(Haak et al.,2015;Wang et al.,2021,2024)to enhance the accessibility and utilit... The analysis of ancient genomics provides opportunities to explore human population history across both temporal and geographic dimensions(Haak et al.,2015;Wang et al.,2021,2024)to enhance the accessibility and utility of these ancient genomic datasets,a range of databases and advanced statistical models have been developed,including the Allen Ancient DNA Resource(AADR)(Mallick et al.,2024)and AdmixTools(Patterson et al.,2012).While upstream processes such as sequencing and raw data processing have been streamlined by resources like the AADR,the downstream analysis of these datasets-encompassing population genetics inference and spatiotemporal interpretation-remains a significant challenge.The AADR provides a unified collection of published ancient DNA(aDNA)data,yet its file-based format and reliance on command-line tools,such as those in Admix-Tools(Patterson et al.,2012),require advanced computational expertise for effective exploration and analysis.These requirements can present significant challenges forresearchers lackingadvanced computational expertise,limiting the accessibility and broader application of these valuable genomic resources. 展开更多
关键词 DATABASE raw data processing analysis ancient genomics upstream processes ancient DNA explore human population history allen ancient dna resource aadr mallick ancient genomic datasetsa
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Tim4 deficiency reduces CD301b+macrophage and aggravates periodontitis bone loss 被引量:2
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作者 Ziming Wang Hao Zeng +11 位作者 Can Wang Jiaolong Wang Jing Zhang Shuyuan Qu Yue Han Liu Yang Yueqi Ni Wenan Peng Huan Liu Hua Tang Qin Zhao Yufeng Zhang 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第2期280-292,共13页
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in... Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone resorption.CD301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone regeneration.However,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain elusive.In this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)macrophages.We first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA sequencing.Moreover,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)macrophages.The single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in macrophages.The following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis progressed.Furthermore,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in periodontitis.Additionally,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages phenotype.In a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis. 展开更多
关键词 PERIOD UPSTREAM eventually
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A 48-bp deletion upstream of LIGULELESS 1 alters rice panicle architecture 被引量:1
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作者 Linhua Wu Min Hu +6 位作者 Shuwei Lyu Wenfeng Chen Hang Yu Qing Liu Wei He Chen Li Zuofeng Zhu 《The Crop Journal》 SCIE CSCD 2024年第2期354-363,共10页
Panicle architecture is an agronomic determinant of crop yield and a target for cereal crop improvement.To investigate its molecular mechanisms in rice,we performed map-based cloning and characterization of OPEN PANIC... Panicle architecture is an agronomic determinant of crop yield and a target for cereal crop improvement.To investigate its molecular mechanisms in rice,we performed map-based cloning and characterization of OPEN PANICLE 1(OP1),a gain-of-function allele of LIGULELESS 1(LG1),controlling the spread-panicle phenotype.This allele results from a 48-bp deletion in the LG1 upstream region and promotes pulvinus development at the base of the primary branch.Increased OP1 expression and altered panicle phenotype in chimeric transgenic plants and upstream-region knockout mutants indicated that the deletion regulates spread-panicle architecture in the mutant spread panicle 1(sp1).Knocking out BRASSINOSTEROID UPREGULATED1(BU1)gene in the background of OP1 complementary plants resulted in compact panicles,suggesting OP1 may regulate inflorescence architecture via the brassinosteroid signaling pathway.We regard that manipulating the upstream regulatory region of OP1 or genes involved in BR signal pathway could be an efficient way to improve rice inflorescence architecture. 展开更多
关键词 Upstream region Panicle architecture Gene expression BR Rice
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Hydrocarbon Generation Characteristics of Coal-measure Source Rocks and their Contribution to Natural Gas:A Case Study of Middle and Lower Jurassic Targets from the Southern Junggar Basin Margin 被引量:1
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作者 YU Miao GAO Gang +6 位作者 LIU Miao MA Wanyun TIAN Anqi FAN Keting GUO Liulinbo HE Dan ZHANG Youjin 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第5期1270-1284,共15页
In order to study the hydrocarbon generation(HCGE)characteristics of coal-bearing basins,the coal-measure source rocks of the Middle Jurassic-Lower Jurassic(MLJ)of the piedmont thrust belt in the southern margin of th... In order to study the hydrocarbon generation(HCGE)characteristics of coal-bearing basins,the coal-measure source rocks of the Middle Jurassic-Lower Jurassic(MLJ)of the piedmont thrust belt in the southern margin of the Junggar Basin in Northwest China are taken as research objects.More than 60 MLJ samples were collected from outcrops and wells.Total organic carbon(TOC),rock pyrolysis(Rock-Eval),organic petrological,vitrinite reflectance(%Ro),and hydrous pyrolysis were performed to analyze the relevant samples.The pyrolysis gases and liquid products were measured,and then the chemical composition,as well as carbon isotopes of the gases,were analyzed.The results indicate that the MLJ source rocks have the capacity for large-scale gas generation.In addition,for coal-measure source rocks,the heavier the carbon isotope of kerogen(δ^(13)C_(kerogen)),the lower the liquid hydrocarbon and hydrocarbon gas yield,and the easier it is to produce non-hydrocarbon gas.It is worth noting that when theδ^(13)C_(kerogen)in organic matter(OM)is relatively heavier,the fractionation of its products may become weaker in the evolutionary process.The vital contribution of the MLJ source rock to natural gas resources in the study area was further confirmed by comparing it with the Jurassic source gas. 展开更多
关键词 upstream natural resources/energy coal-bearing basins source rock hydrous pyrolysis carbon isotope JURASSIC Xinjiang province
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Body-force modeling considering induced upstream effects for a transonic compressor with total temperature distortion 被引量:1
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作者 Jiahui QIU Chen YANG +2 位作者 Wenqiang ZHANG Min ZHANG Juan DU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第6期7-19,共13页
To numerically study the impact of total temperature distortion on a transonic compressor with reduced computational costs,a Body-Force Model(BFM)is developed.Firstly,the interactions between the distorted flow and th... To numerically study the impact of total temperature distortion on a transonic compressor with reduced computational costs,a Body-Force Model(BFM)is developed.Firstly,the interactions between the distorted flow and the compressor are analyzed using full-annulus Unsteady Reynolds-Averaged Navier-Stokes(URANS)results and the orbit method.It is found that the induced swirl distortion and the mass flux nonuniformity are intensified in the compressor upstream flow field.A correction factor is thus added to the BFM to account for the effect of the induced swirl,which is crucial for the accurate representation of distortion transfer in the intake.Then,steady simulations with large-amplitude 180circumferential total temperature distortion are performed using the developed BFM.It is shown that the distorted compressor map simulated with the BFM matches well with URANS results.The circumferential phase shift of total temperature and the generation of the additional total pressure distortion across the rotor are in line with the time-averaged URANS flow field.The compressor upstream effects on the distorted inflow can also be exactly captured.All above-mentioned results demonstrate the BFM developed in this paper can effectively capture the distorted flow features inside the compressor,and significantly reduce the computational costs by five orders of magnitude compared with URANS. 展开更多
关键词 Upstream effect Orbit method Induced swirl distortion Body force model Correction factor Time-averaged URANS
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The upstream rare earth resources of Malaysia:Insight into geology,geochemistry,and hydrometallurgical approaches
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作者 Syed Muhammad Ibad Haylay Tsegab +5 位作者 Numair Ahmed Siddiqui Monera Adam Santosh Mishra Syahrir Ridha Nisar Ahmed Afifa Azmi 《Geoscience Frontiers》 SCIE CAS CSCD 2024年第6期277-302,共26页
Peninsular Malaysia is already well known for having rare earth(RE)resources.However,pertinent data and information on upstream RE resources and reserve potential in Malaysia are yet to be established.It is vital to i... Peninsular Malaysia is already well known for having rare earth(RE)resources.However,pertinent data and information on upstream RE resources and reserve potential in Malaysia are yet to be established.It is vital to identify opportunities and challenges for value addition to rare earth elements(REEs)deposits in Malaysia.Therefore,this study evaluates the potential of Malaysian geological formations to serve as repositories for RE resources,such as rare earth minerals(REMs)and REEs,by elucidating the geological processes that are considered critical to the formation of the various deposit types.This paper concisely reviews possible REE mineralization in alkaline igneous rocks,pegmatites,placer deposits:monazite and xenotime,marine sediments,river and lake sediments,ion adsorption clays(IAC)deposits,and shale/coal deposits found in Malaysia.Comparisons between Malaysian deposits revealed that these deposits are potentially enriched with RE resources showing geological formations across the world.The paper reviews the methods and flowsheets used for the recovery of REMs and REEs from primary,secondary as well as alternative resources,with special consideration to the hydrometallurgical procedures comprising of leaching with acids and alkalis tailed by ion exchange,solvent extraction,or precipitation.The REEs ecosystem of Malaysia has also been discussed by considering the latest information from the Malaysian Investment Development Authority(MIDA),the REEs processing center,the Academy of Science of Malaysia(ASM),the People’s Republic of China(PRC),Lynas Malaysia Sdn.Bhd.(Lynas),Ministry of Energy and Natural Resources(NRECC),Jabatan Mineral&Geosains(JMG),Ministry of Science,Technology,and Innovation(MOSTI),and the Malaysian Chamber of Mines.The information on upstream RE resources and recent hydrometallurgical approaches provided in this study will contribute to developing and enhancing midstream and downstream RE-based manufacturing and processing operations in Malaysia. 展开更多
关键词 Upstream resource Rare earth Alkaline igneous rocks Marine sediments Ion adsorption clays
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Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis
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作者 Zi-Ling Hu Yu-Xuan Wang +4 位作者 Zi-Yue Lin Wen-Shuo Ren Bo Liu Hui Zhao Qiong Qin 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第7期1344-1362,共19页
Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual impairment.Increasing evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress o... Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual impairment.Increasing evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological role.Nuclear factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative genes.Its functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been elucidated.Understanding the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD pathogenesis.For the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD. 展开更多
关键词 NRF2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress
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Influence of upstream solar wind on magnetic field distribution in the Martian nightside ionosphere
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作者 JiaWei Gao ZhaoJin Rong +3 位作者 Qi Zhang Anna Mittelholz Chi Zhang Yong Wei 《Earth and Planetary Physics》 EI CAS CSCD 2024年第5期728-741,共14页
Using over eight years of Mars Atmosphere and Volatile Evolutio N(MAVEN)data,from November 2014 to May 2023,we have investigated the Martian nightside ionospheric magnetic field distribution under the influence of ups... Using over eight years of Mars Atmosphere and Volatile Evolutio N(MAVEN)data,from November 2014 to May 2023,we have investigated the Martian nightside ionospheric magnetic field distribution under the influence of upstream solar wind drivers,including the interplanetary magnetic field intensity(∣BIMF∣),solar wind dynamic pressure(PS W),solar extreme ultraviolet flux(EUV),and Martian seasons(L s).Our analysis reveals pronounced correlations between magnetic field residuals and both∣BIMF∣and PS W.Correlations observed with EUV flux and Ls were weaker—notably,magnetic field residuals increased during periods of high EUV flux and at Mars perihelion.We find that the IMF penetrates to an altitude of 200 km under a wide range of upstream conditions,penetrating notably deeper under high∣BIMF∣andPSWconditions.Our analysis also indicates that EUV flux and IMF cone angle have minimal impact on IMF penetration depth.Those findings provide useful constraints on the dynamic nature of Martian atmospheric escape processes and their evolution,suggesting that historical solar wind conditions may have facilitated deeper IMF penetration and higher rates of ionospheric escape than are observed now.Moreover,by establishing criteria for magnetic‘quiet’conditions,this study offers new insights into the planet’s magnetic environment under varying solar wind influences,knowledge that should help refine models of the Martian crustal magnetic field. 展开更多
关键词 Martian magnetic field external magnetic field upstream solar wind drivers IMF penetration altitude magnetic field activity indices
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Effects of Effluent from a Dumpsite on the Physicochemical Properties of River Achichum in Bamendakwe, Northwest Cameroon
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作者 Mofor Nelson Alakeh Keuwo Tiayong Francois +2 位作者 Nchofua Festus Biosengazeh Mikwa Cyprian Chunkang Njoyim Estella Buleng Tamungang 《Journal of Environmental Protection》 2024年第9期934-947,共14页
This study was aimed to assess the effects of effluent from a dumpsite on the physicochemical properties of river Achichum in Bamendakwe in the Bamenda I municipality, Northwest Region of Cameroon. The quality of wate... This study was aimed to assess the effects of effluent from a dumpsite on the physicochemical properties of river Achichum in Bamendakwe in the Bamenda I municipality, Northwest Region of Cameroon. The quality of water used for domestic purposes by the population of this area is mostly appreciated through its organoleptic assessment while no attention is paid to the physicochemical and microbiological properties. Samples (upstream, effluent, and downstream) were collected in the months of September 2022 and February 2023 and examined for organoleptic, physicochemical and bacteriological characteristics using standard methods. The river was contaminated to different extents by nitrates (28.56 - 149.91 mg/L), sulphates (246.89 - 725.42 mg/L) and heavy metals (0.01 - 0.04 mg/L for lead and 0.98 - 2.15 mg/L for aluminum). This contamination could be due to an inflow of the untreated effluent into the river. The river contained a high pollution level of lead and aluminum. Bacteriological investigations revealed that all the analyzed samples from the river contained indicators of faecal pollution such as Enterobacteria spp., E. coli, Streptococcus spp., Salmonella spp., Shigella spp., Staphylococcus spp. and Vibrio spp. Consequently, its utilization exposes consumers to health risks. Thus, water from the river should be treated prior to consumption. 展开更多
关键词 EFFLUENT UPSTREAM DOWNSTREAM Water Quality Faecal Contamination Bamendakwe
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Dissolved Organic Matter Features of Three Adjacent Eastern Mediterranean Urbanized Watersheds
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作者 Nour Abboud Elias Michel Maatouk +1 位作者 Zeinab Matar Veronique Kazpard 《Open Journal of Modern Hydrology》 CAS 2024年第3期153-173,共21页
Landscape urbanization broadly affects ecosystems in coastal watersheds, but, until now, the influence of nonpoint source urban inputs on dissolved organic matter (DOM) amount, composition, and source is poorly unders... Landscape urbanization broadly affects ecosystems in coastal watersheds, but, until now, the influence of nonpoint source urban inputs on dissolved organic matter (DOM) amount, composition, and source is poorly understood. To understand how DOM composition varied with urbanization, fluorescence excitation-emission matrices (EEMs) were determined for urban and non-urban waters from upstream to downstream sites along three adjacent coastal watersheds that flow into the Mediterranean Sea. Two humic DOM fluorescent components (humic-like and fulvic-like peaks) and two proteinic components (tyrosine-like and tryptophane-like peaks) were identified by EEM fluorescence. The results indicated that urbanization had an important influence on DOM concentration and composition, with urban waters having a high degree of DOM variation due to different land uses surrounding each body of water. Urban waters show a higher DOM fluorescence index (FI), the highest fluorescence intensity of protein-like manifested also by BIX values, and a lower value of the humification index (HIX) than non-urban waters which were dominated by allochthonous inputs. In addition, the EEM was compared in dry and wet season where higher DOM amounts and FI appeared in summer due to autochthonous production coming from algae growth compared to allochthonous input from rainfall dominated in wet season. The concentration of DOC increased from upstream to downstream for the three rivers, especially Beirut River. The increase in DOC values was observed in both dry and wet seasons by 39 and 19 times respectively compared to upstream (0.93 - 0.91 mgC/L). 展开更多
关键词 Dissolved Organic Matter DOM EEM Fluorescence Spectroscopy Autochthonous/Allochthonous DOM Urbanization Upstream/Downstream Wet/Dry Season
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FLOURISHING IN THE VALLEY
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作者 Xie Xiaochun(Text/Photos) Gao Yujie(Text/Photos) +3 位作者 Wang Shan(Text/Photos) Zhao Shubin(Text/Photos) Wan Jing(Text/Photos) Li Qing(Translated) 《China's Tibet》 2024年第6期4-7,共4页
Farewell to Yigong Township in Bomi County,Nyingchi,we journeyed upstream along the Yigong Tsangpo River in the Xizang Autonomous Region.We arrived at the picturesque Bagai Township,cradled by snow-capped mountains.
关键词 MOUNTAINS UPSTREAM PICTURE
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Variation Characteristics of Main Climate Factors in the Upstream of Wei River in Recent 39 Years 被引量:5
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作者 姚小英 蒲金涌 刘晓强 《Meteorological and Environmental Research》 CAS 2010年第9期9-11,共3页
Wei River is an important river which affects the industrial and agricultural production,people's life in Guanzhong district of Shaanxi and the east of Gansu.To study the variation characteristics of main climate ... Wei River is an important river which affects the industrial and agricultural production,people's life in Guanzhong district of Shaanxi and the east of Gansu.To study the variation characteristics of main climate factors in recent 39 years in the upstream of Wei River,we analyzed the variation characteristics of climate factors by using the data in 11 meteorological stations in the upstream basin of Wei River during 1971-2009.The results showed that the precipitation presented the decline trend in the basin,and the temperature rose in 0.3 ℃/10 a trend.The temperature increase trend was 0.4 ℃/10 a in winter,spring and wasn't obvious in summer,autumn.The potential evapotranspiration presented the yearly increase trend in recent years.The precipitation decreased,and the temperature rose.Moreover,the potential evapotranspiration strengthened.It wasn't favorable for the healthy run of ecological system in the upstream,downstream basins and aggravated the shortage degree of water resources. 展开更多
关键词 Wei River upstream Climate factor Variation CHARACTERISTIC China
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