By considering the effect of suspended solid particles in the ordinary equations for two-dimension inviscid incompressible mixing layer, the Rayleigh equation and the modified Rayleigh equation are obtained. And then,...By considering the effect of suspended solid particles in the ordinary equations for two-dimension inviscid incompressible mixing layer, the Rayleigh equation and the modified Rayleigh equation are obtained. And then, by solving the corresponding eigen-value equations with numerical computational method, the relation curves between perturbation frequency and spacial growth rate of the mixing layer for the varying particle loading, ratio of particle velocity to fluid velocity and Stokes number are got. Sever al important conclusions on the effect of suspended solid particles on unstability of the mixing layer are presented in the end by analyzing all the relation curves.展开更多
The unstability of cytoplasmic male sterilities (CMS) of Brassica napus Lwas stud-ied from 1989 to 1992,and the results indicated: 1. The occurrence of trace-pollen plants In sterilematerials was caused by nuclear pol...The unstability of cytoplasmic male sterilities (CMS) of Brassica napus Lwas stud-ied from 1989 to 1992,and the results indicated: 1. The occurrence of trace-pollen plants In sterilematerials was caused by nuclear polygenes of the maintainers; 2. Progenies of partial sterility typeshowed segregation of sterile, partially sterile (with trace pollen )and fertile plants; 3. High andlow temperature CMS lines were crossed and its progenies manifested complex segregation; 4.There was a tendency to increase the fertility with successive selfing of the high temperatureCMS line.展开更多
BACKGROUND Unstable intertrochanteric fractures in elderly patients require effective surgical management,with both cementless bipolar hemiarthroplasty(CBHA)and proximal femoral nail anti-rotation(PFNA)being valid tre...BACKGROUND Unstable intertrochanteric fractures in elderly patients require effective surgical management,with both cementless bipolar hemiarthroplasty(CBHA)and proximal femoral nail anti-rotation(PFNA)being valid treatment options to reduce morbidity and mortality.AIM To evaluate and compare the outcomes of CBHA and PFNA in treatment of unstable intertrochanteric fractures.METHODS A comprehensive search was conducted to identify relevant studies discussing the outcomes of using both CBH and PFNA in treatment of unstable intertrochanteric fractures.Studies published up to January 1,2025 were searched across multiple databases,including PubMed,EMBASE,Scopus,Web of Science,Cochrane Library,and Google Scholar.Full texts of the selected articles were retrieved,reviewed,and independently assessed by the investigators.Discrepancies were resolved by consensus,with any remaining disagreements being arbitrated by a third author.RESULTS This meta-analysis included three studies,all of which were retrospective,involving a total of 240 patients.The follow-up period for participants was at least 12 months.CBHA was associated with significantly higher blood loss compared to PFNA[mean differences(MD):129.14,95%CI(52.51,205.77),P=0.001],though heterogeneity was high(I²=97%).Operative time showed no significant difference initially[MD:6.10,95%CI(-13.34,25.54),P=0.54],but after excluding one study,BHA had longer operative times[MD:21.51,95%CI(18.60,24.41),P<0.00001].Hospital stay and Harris scores showed no significant differences between groups.CBHA facilitated faster progression to weight-bearing[MD:-11.92,95%CI(-22.46,-1.39),P=0.03]and a lower incidence of prosthetic loosening[risk ratio:0.21,95%CI(0.05,0.92),P=0.04].Refracture and thrombus formation rates were comparable between the two groups.CONCLUSION CBHA offers shorter weight-bearing duration and reduced prosthetic loosening but incurs greater blood loss and longer operative times compared to PFNA.Both techniques show comparable functional recovery,hospital stay,refracture,and thrombus risks.Clinical choice should prioritize early mobilization or surgical minimalism,guided by patient needs.Further prospective studies are warranted.展开更多
Pre-injection is a technique that involves injecting grout materials into the ground prior to excavation,with the aim of stabilizing the surrounding rock mass.This paper introduces an analytical closed-form model for ...Pre-injection is a technique that involves injecting grout materials into the ground prior to excavation,with the aim of stabilizing the surrounding rock mass.This paper introduces an analytical closed-form model for determining the ground reaction curve of tunnels in rock masses exhibiting elastic-brittleplastic behavior and adhering to the Mohr-Coulomb failure criterion.The model incorporates the reinforced region created by the pre-injection method.When the rock mass is reinforced through preinjection,plastic regions can form independently in both the natural and injected rock masses.This leads to six distinct modes of the problem.The analytical model presented in this paper considers three possible scenarios for the development of plastic regions.Each scenario comprises four stages,with each stage representing a different mode of the problem.While injecting the rock mass can enhance its strength and stiffness,it may also increase the brittleness of the injected rock mass and create stress concentrations within it,particularly when brittle grouts are used.As a result,this can elevate the risk of rockburst due to unstable failure.The results obtained from the model demonstrate that ductile grout performs exceptionally well in controlling tunnel convergence in rock masses,as it accommodates deformation without sudden failure,even in squeezing rock mass conditions.Conversely,the use of brittle grouts should be approached with caution,particularly in squeezing rock masses,due to their susceptibility to rockburst incidents.展开更多
Background and Objective Inflammation plays a pivotal role in the progression of coronary artery disease(CAD).High-sensitivity C-reactive protein(hsCRP)serves as a well-established biomarker for assessing cardiovascul...Background and Objective Inflammation plays a pivotal role in the progression of coronary artery disease(CAD).High-sensitivity C-reactive protein(hsCRP)serves as a well-established biomarker for assessing cardiovascular inflammation risk.However,the specific intestinal microbiota alteration contributing to increased inflammation remains unclear.Therefore,the present study investigated the correlation between the intestinal microbiota and inflammation in patients with unstable angina(UA).Methods A cohort of 92 patients with UA was recruited for this study.The plasma hsCRP level was measured via a CardioPhase hsCRP assay,fecal samples were collected after admission,and 16S rRNA sequencing was conducted to identify the fecal microbial profile.The participants were classified into two groups according to the median hsCRP level(1.11 mg/L).The composition of the fecal microbiota was compared between patients with hsCRP≥1.11 mg/L and those with hsCRP<1.11 mg/L.Additionally,the correlations between the fecal microbiota and clinical characteristics were analyzed.Results A notable reduction in the relative abundance of Akkermansia was observed in patients with hsCRP≥1.11 mg/L,whereas the diversity of the fecal microbiota was not significantly different between patients with hsCRP≥1.11 mg/L and those with hsCRP<1.11 mg/L.Furthermore,the abundance of Akkermansia was negatively correlated with hsCRP levels.Conclusion This study suggested a significant association between decreased levels of Akkermansia and inflammatory risk in patients with UA.These findings underscore the potential role of the intestinal microbiota in contributing to inflammation in UA patients.Further work is needed on the mechanism by which the microbiota contributes to inflammatory risk.展开更多
As 2025 unfolds,global economic growth remains lackluster,protectionism is intensifying,and key markets are grappling with weak growth prospects and mounting debt burdens.As the external environment grows ever more un...As 2025 unfolds,global economic growth remains lackluster,protectionism is intensifying,and key markets are grappling with weak growth prospects and mounting debt burdens.As the external environment grows ever more uncertain and unstable,China is poised at a pivotal crossroads in its economic transformation.展开更多
BACKGROUND Pedicle screw fixation is frequently used to treat unstable thoracolumbar injuries;however,the rate of instrumentation failure remains considerable.The primary contributing factor leading to instrumentation...BACKGROUND Pedicle screw fixation is frequently used to treat unstable thoracolumbar injuries;however,the rate of instrumentation failure remains considerable.The primary contributing factor leading to instrumentation failure is poor bone quality.On the other hand,some evidence suggests that surgical tactics can influence long-term instrumentation stability.AIM To assess factors that influence the stability of spinal instrumentation in patients with thoracolumbar injuries.METHODS This study is a non-randomized single center ambispective evaluation of 204 consecutive patients(117 men;87 women)with unstable thoracolumbar injuries.All patients underwent either stand-alone or combined with anterior column reconstruction instrumentation.In cases with spinal cord and nerve root injuries,either posterior or anterior decompression were performed.Patients with pedicle screw loosening were identified via computed tomography imaging.Out of those,cases with clinically significant instrumentation failure were registered.RESULTS The rate of pedicle screw loosening detected by computed tomography was inversely correlated with bone radiodensity figures and an increased association with the number of instrumented levels,residual kyphotic deformity,laminectomy,and lumbosacral fixation.Intermediate screws and anterior reconstruction were associated with a clinically relevant decreased risk of pedicle screw loosening development.Either complete or partial posterior fusion within instrumented levels was capable of decreasing instrumentation failure risk,while extensive decompression with laminectomy and at least one-level total facetectomy were associated with an increased risk of instrumentation failure.Anterior decompression does not have a negative impact on instrumentation stability.CONCLUSION Intermediate screws,anterior reconstruction and posterior tension band preservation are associated with decreased rates of instrumentation instability development.Posterior fusion is beneficial in terms of instrumentation failure prevention.展开更多
[Objectives]To explore the clinical efficacy of Qinjin Tablet in treating unstable angina with phlegm-stasis syndrome and preliminarily explore its intervention mechanism.[Methods]Sixty unstable angina patients with p...[Objectives]To explore the clinical efficacy of Qinjin Tablet in treating unstable angina with phlegm-stasis syndrome and preliminarily explore its intervention mechanism.[Methods]Sixty unstable angina patients with phlegm-stasis syndrome were randomly divided into a treatment group and a control group(30 each).The control group received standardized Western medicine treatment,while the treatment group also took Qinjin Tablet.After a 4-week treatment,comparisons were made on improvement of angina symptoms,TCM syndrome scores,blood stasis scores,reduction/cessation of short-acting anti-angina drugs,Seattle Angina Questionnaire(SAQ)scores,blood lipid levels,and matrix metalloproteinase-9(MMP-9)concentrations between the two groups.[Results]No statistical differences existed in baseline data like age,gender,and disease duration between the two groups(P>0.05).The treatment group showed significantly better efficacy than the control group in improving angina symptoms,TCM syndrome scores,blood stasis scores,and reduction or discontinuation of short-acting anti-anginal drugs(P<0.05).The SAQ score increase was more significant in the treatment group(P<0.05).The control group significantly reduced low-density lipoprotein cholesterol(LDL-C)(P<0.05),while the treatment group markedly increased high-density lipoprotein cholesterol(HDL-C)(P<0.05).Post-treatment,the treatment group had a marked reduction in serum MMP-9(P<0.05),with no significant change in the control group.[Conclusions]Qinjin Tablet can significantly alleviate clinical symptoms and improve quality of life in UA patients by modulating the HDL-C/MMP-9 signaling pathway.展开更多
Due to the coexistence of compressibility,viscosity,and threedimensional effects,laminar flow is difficult to maintain for high-speed boundary layer on complex geometries.The unstable disturbance waves in the boundary...Due to the coexistence of compressibility,viscosity,and threedimensional effects,laminar flow is difficult to maintain for high-speed boundary layer on complex geometries.The unstable disturbance waves in the boundary layer are excited and rapidly increase during the receptivity process,so sufficiently large Reynolds stress causes the basic flow velocity profile to change,and the formation of turbulence is inevitable.展开更多
In this paper,a nonlinear control approach for an unstable networked plant in the presence of actuator and sensor limitations using robust right coprime factorization is proposed.The actuator is limited by upper and l...In this paper,a nonlinear control approach for an unstable networked plant in the presence of actuator and sensor limitations using robust right coprime factorization is proposed.The actuator is limited by upper and lower constraints and the sensor in the feedback loop is subjected to network-induced unknown time-varying delay and noise.With this nonlinear control method,we first employ right coprime factorization based on isomorphism and operator theory to factorize the plant,so that bounded input bounded output(BIBO)stability can be guaranteed.Next,continuous-time generalized predictive control(CGPC)is utilized for the unstable operator of the right coprime factorized plant to guarantee inner stability and enables the closed-loop dynamics of the system with predictive characteristics.Meanwhile,a second-Do F(degrees of freedom)switched controller that satisfies a perturbed Bezout identity and a robustness condition is designed.By using the CGPC controller that possesses predictive behavior and the second-Do F switched stabilizer,the overall stability of the plant subjected to actuator limitations is guaranteed.To address sensor limitations that exist in networked plants in the form of delay and noise which often cause system performance degradation,we implement an identity operator definition in the feedback loop to compensate for these adverse effects.Further,a pre-operator is designed to ensure that the plant output tracks the reference input.Finally,the effectiveness of the proposed design scheme is demonstrated by simulations.展开更多
Convectively unstable processes caused by dense water subsidence are common occurrences in high-latitude oceanic regions,and significantly modulate mass and heat transport and mixing processes in the ocean.An idealize...Convectively unstable processes caused by dense water subsidence are common occurrences in high-latitude oceanic regions,and significantly modulate mass and heat transport and mixing processes in the ocean.An idealized numerical experiment using the large eddy simulation method was conducted to analyze the three-dimensional flow field structure and the mechanism for dense water subsidence.Specifically,a negative salt flux is set at the sea surface,in which salt flux enters the sea surface to simulate the icing and salting-out phenomena that occur at high latitudes.Results show that the mean-state 3D flow field of dense water subsidence exhibits a hollow conical distribution.The horizontal flow field is characterized by a cyclonic vortex that driven primarily by the pressure gradient and influenced by the Coriolis effect.Moreover,the inverse vertical pressure gradient generated by this vortex inhibits the sinking of the plume,leading to its off-axis deflection and the development of an anticyclonic precession.In addition,the impact of rotation on the structure of a sinking plume within a stratified environment is discussed.Both horizontal vortex intensity and cone angle of the hollow cone flow field are increased with increasing rotation rate,resulting in a decrease in the plume’s maximum sinking depth.Variances in rotation direction cause the horizontal vortex and sinking plumes of dense water in the northern and southern hemispheres to rotate in opposite directions.展开更多
Objective:To evaluate and analyze the actual efficacy of percutaneous vertebroplasty in the treatment of old unstable osteoporotic spinal fractures.Methods:From March 2023 to March 2024,46 patients with old unstable o...Objective:To evaluate and analyze the actual efficacy of percutaneous vertebroplasty in the treatment of old unstable osteoporotic spinal fractures.Methods:From March 2023 to March 2024,46 patients with old unstable osteoporotic spinal fractures in our hospital were included in this study.They were divided into the conventional group and the observation group based on treatment differences,with 23 patients in each group.The conventional group received conservative drug therapy,while the observation group underwent percutaneous vertebroplasty.The following indicators were compared and analyzed between the two groups:clinical treatment effect and improvement in physical function indicators.Results:The treatment efficiency of the observation group was 95.65%(22/23),while that of the conventional group was 69.57%(16/23).There was a significant difference between the groups,and the treatment effect of the observation group was significantly better(P<0.05).After treatment,the scores of physical status,daily living ability,functional independence,and life obstacles in the observation group were(89.33±4.08),(88.72±4.08),(90.41±2.89),(72.35±3.22),respectively,while those in the conventional group were(68.54±4.21),(67.42±4.11),(73.48±2.75),(72.35±3.22).There was a significant difference between the groups,and the improvement in physical function indicators in the observation group was more pronounced(P<0.05).Conclusion:For patients with old unstable osteoporotic spinal fractures,the basic value of percutaneous vertebroplasty is significant.It can not only improve clinical efficacy and safety but also promote the gradual recovery of patients'physical function indicators.It is recommended for clinical reference and practical application.展开更多
Interactions among ecosystem services(ESs)are spatially heterogeneous,shaped by both stable(unidirectional)and unstable(context-dependent)influences of socio-economic development and climate change.These complexities ...Interactions among ecosystem services(ESs)are spatially heterogeneous,shaped by both stable(unidirectional)and unstable(context-dependent)influences of socio-economic development and climate change.These complexities pose significant challenges for spatially adaptive ecosystem management.Ecosystem service bundles(ESBs),as recurring combinations of ESs,offer a valuable framework to capture such interactions.Here,we proposed an integrated analytical framework that combines K-means clustering,the geographical detector(GD)model,and geographically and temporally weighted regression(GTWR)models to evaluate how socio-economic and climatic drivers influence ESBs across space and time.Using Hanshui River Basin(HRB)in central China as a case study,we quantified ES dynamics from 2000 to 2020,identified ESBs and stable and unstable effects of multiple drivers.The results showed that carbon sequestration(CS),water yield(WY),and aesthetic landscape(AL)increased by 32.80%,9.00%,and 7.34%,respectively,while soil retention(SR)and food supply(FS)declined by 8.38%and 5.36%.Five distinct ESBs were identified,namely ecologically fragile bundle(EFB),agricultural production bundle(APB),water supply bundle(WSB),forest ecological bundle(FEB),and ecological conservation bundle(ECB).Among these,FEB expanded to more than 35.75%of the HRB,and APB exhibited the sharpest decline(-28.64%).Land use intensity(LUI)was the primary driver of the spatial heterogeneity of ESBs,while synergistic and nonlinear interactions among multiple factors increasingly amplified their effects over time.Notably,annual precipitation(AP)emerged as the only stable basin-scale driver,consistently enhancing ES performance,while gross domestic product(GDP)and normalized difference vegetation index(NDVI)had stable yet spatially differentiated effects across bundles.Our findings highlight the significance of distinguishing stable/unstable driver effects on ES dynamics to inform regionally adaptive ecosystem governance.The proposed framework provides valuable insights into ES interactions,identify spatial priorities,and support policy interventions that balance ecological conservation with socio-economic development.展开更多
Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and ...Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and Conclusion The criteria for singular points, closed orbits and hyperbolic equilibrium points of a second order autonomous Birkhoff system are given. Moreover the stability of equilibria, stable manifolds and unstable manifolds are obtained.展开更多
A method is proposed for prediction of the unstable deformation in hot forging process using both the determined thermomechnical parameter windows of the unstable deformation zones and finite element simulation. Takin...A method is proposed for prediction of the unstable deformation in hot forging process using both the determined thermomechnical parameter windows of the unstable deformation zones and finite element simulation. Taking Ti-6.5Al-3.5Mo-1.5Zr-0.3Si alloy as the testing material, the thermomechnical parameter windows of the unstable deformation zones for the Ti-alloy are integrated into a commercial finite element simulation software platform. The distribution and variation of the unstable deformation zones of the alloy in hot compression process are simulated and predicted using the tailor-made finite element codes in the finite element platform. The simulation results tally with the physical experiments and the proposed method for simulation and prediction of the unstable deformation is thus verified and its efficiency is validated.展开更多
Objective Compare the morphology of atherosclerotic plaquesmgiographically and histopathologically in acute myocardialmfarction m order to accumulate experience in recognizing plaquerupture and thrombus by angiogrames...Objective Compare the morphology of atherosclerotic plaquesmgiographically and histopathologically in acute myocardialmfarction m order to accumulate experience in recognizing plaquerupture and thrombus by angiogrames.Material and methods 16postmortem cases of acute myocardial infarction were studied.The coronary arteries were romoved en block,filled with barium the lumen and ridiographed.Then the arteries wereontinuously insetted and routin HE sections were made.Results 16 cases had plaque ruptures and thrombi.Among the total98 blocks,21 had plaque ruptures on which 20 thrombiccur(95.23%).while the other 777 unrupured blocks had only 2hrombi(0.25%).The difference was significant(p【0.001).Therupture mostly occur on unstable plaques.The ruptured plaqueswith thrombi had different angiographical morphology withunruptured plaques.The former had irregular borders andunraluminal lucencies;while the Iatter had smooth borders and nointraluminal lucencies.Conclusions Plaque ruprure withthrumbus was the major cause of acute myocardial infarction andthe ruptured plaques with thrombus had different angiographicalapperances with unruptured plaques.展开更多
文摘By considering the effect of suspended solid particles in the ordinary equations for two-dimension inviscid incompressible mixing layer, the Rayleigh equation and the modified Rayleigh equation are obtained. And then, by solving the corresponding eigen-value equations with numerical computational method, the relation curves between perturbation frequency and spacial growth rate of the mixing layer for the varying particle loading, ratio of particle velocity to fluid velocity and Stokes number are got. Sever al important conclusions on the effect of suspended solid particles on unstability of the mixing layer are presented in the end by analyzing all the relation curves.
文摘The unstability of cytoplasmic male sterilities (CMS) of Brassica napus Lwas stud-ied from 1989 to 1992,and the results indicated: 1. The occurrence of trace-pollen plants In sterilematerials was caused by nuclear polygenes of the maintainers; 2. Progenies of partial sterility typeshowed segregation of sterile, partially sterile (with trace pollen )and fertile plants; 3. High andlow temperature CMS lines were crossed and its progenies manifested complex segregation; 4.There was a tendency to increase the fertility with successive selfing of the high temperatureCMS line.
文摘BACKGROUND Unstable intertrochanteric fractures in elderly patients require effective surgical management,with both cementless bipolar hemiarthroplasty(CBHA)and proximal femoral nail anti-rotation(PFNA)being valid treatment options to reduce morbidity and mortality.AIM To evaluate and compare the outcomes of CBHA and PFNA in treatment of unstable intertrochanteric fractures.METHODS A comprehensive search was conducted to identify relevant studies discussing the outcomes of using both CBH and PFNA in treatment of unstable intertrochanteric fractures.Studies published up to January 1,2025 were searched across multiple databases,including PubMed,EMBASE,Scopus,Web of Science,Cochrane Library,and Google Scholar.Full texts of the selected articles were retrieved,reviewed,and independently assessed by the investigators.Discrepancies were resolved by consensus,with any remaining disagreements being arbitrated by a third author.RESULTS This meta-analysis included three studies,all of which were retrospective,involving a total of 240 patients.The follow-up period for participants was at least 12 months.CBHA was associated with significantly higher blood loss compared to PFNA[mean differences(MD):129.14,95%CI(52.51,205.77),P=0.001],though heterogeneity was high(I²=97%).Operative time showed no significant difference initially[MD:6.10,95%CI(-13.34,25.54),P=0.54],but after excluding one study,BHA had longer operative times[MD:21.51,95%CI(18.60,24.41),P<0.00001].Hospital stay and Harris scores showed no significant differences between groups.CBHA facilitated faster progression to weight-bearing[MD:-11.92,95%CI(-22.46,-1.39),P=0.03]and a lower incidence of prosthetic loosening[risk ratio:0.21,95%CI(0.05,0.92),P=0.04].Refracture and thrombus formation rates were comparable between the two groups.CONCLUSION CBHA offers shorter weight-bearing duration and reduced prosthetic loosening but incurs greater blood loss and longer operative times compared to PFNA.Both techniques show comparable functional recovery,hospital stay,refracture,and thrombus risks.Clinical choice should prioritize early mobilization or surgical minimalism,guided by patient needs.Further prospective studies are warranted.
文摘Pre-injection is a technique that involves injecting grout materials into the ground prior to excavation,with the aim of stabilizing the surrounding rock mass.This paper introduces an analytical closed-form model for determining the ground reaction curve of tunnels in rock masses exhibiting elastic-brittleplastic behavior and adhering to the Mohr-Coulomb failure criterion.The model incorporates the reinforced region created by the pre-injection method.When the rock mass is reinforced through preinjection,plastic regions can form independently in both the natural and injected rock masses.This leads to six distinct modes of the problem.The analytical model presented in this paper considers three possible scenarios for the development of plastic regions.Each scenario comprises four stages,with each stage representing a different mode of the problem.While injecting the rock mass can enhance its strength and stiffness,it may also increase the brittleness of the injected rock mass and create stress concentrations within it,particularly when brittle grouts are used.As a result,this can elevate the risk of rockburst due to unstable failure.The results obtained from the model demonstrate that ductile grout performs exceptionally well in controlling tunnel convergence in rock masses,as it accommodates deformation without sudden failure,even in squeezing rock mass conditions.Conversely,the use of brittle grouts should be approached with caution,particularly in squeezing rock masses,due to their susceptibility to rockburst incidents.
基金supported by the National Natural Science Foundation of China(No.82030016,No 82230011 and No.82200533).
文摘Background and Objective Inflammation plays a pivotal role in the progression of coronary artery disease(CAD).High-sensitivity C-reactive protein(hsCRP)serves as a well-established biomarker for assessing cardiovascular inflammation risk.However,the specific intestinal microbiota alteration contributing to increased inflammation remains unclear.Therefore,the present study investigated the correlation between the intestinal microbiota and inflammation in patients with unstable angina(UA).Methods A cohort of 92 patients with UA was recruited for this study.The plasma hsCRP level was measured via a CardioPhase hsCRP assay,fecal samples were collected after admission,and 16S rRNA sequencing was conducted to identify the fecal microbial profile.The participants were classified into two groups according to the median hsCRP level(1.11 mg/L).The composition of the fecal microbiota was compared between patients with hsCRP≥1.11 mg/L and those with hsCRP<1.11 mg/L.Additionally,the correlations between the fecal microbiota and clinical characteristics were analyzed.Results A notable reduction in the relative abundance of Akkermansia was observed in patients with hsCRP≥1.11 mg/L,whereas the diversity of the fecal microbiota was not significantly different between patients with hsCRP≥1.11 mg/L and those with hsCRP<1.11 mg/L.Furthermore,the abundance of Akkermansia was negatively correlated with hsCRP levels.Conclusion This study suggested a significant association between decreased levels of Akkermansia and inflammatory risk in patients with UA.These findings underscore the potential role of the intestinal microbiota in contributing to inflammation in UA patients.Further work is needed on the mechanism by which the microbiota contributes to inflammatory risk.
文摘As 2025 unfolds,global economic growth remains lackluster,protectionism is intensifying,and key markets are grappling with weak growth prospects and mounting debt burdens.As the external environment grows ever more uncertain and unstable,China is poised at a pivotal crossroads in its economic transformation.
基金Supported by AI For Spinal Surgery Planning and Results Assessment Project under the“Priority 2030”Academic Leadership Initiative,No.6.18-01/240724-15.
文摘BACKGROUND Pedicle screw fixation is frequently used to treat unstable thoracolumbar injuries;however,the rate of instrumentation failure remains considerable.The primary contributing factor leading to instrumentation failure is poor bone quality.On the other hand,some evidence suggests that surgical tactics can influence long-term instrumentation stability.AIM To assess factors that influence the stability of spinal instrumentation in patients with thoracolumbar injuries.METHODS This study is a non-randomized single center ambispective evaluation of 204 consecutive patients(117 men;87 women)with unstable thoracolumbar injuries.All patients underwent either stand-alone or combined with anterior column reconstruction instrumentation.In cases with spinal cord and nerve root injuries,either posterior or anterior decompression were performed.Patients with pedicle screw loosening were identified via computed tomography imaging.Out of those,cases with clinically significant instrumentation failure were registered.RESULTS The rate of pedicle screw loosening detected by computed tomography was inversely correlated with bone radiodensity figures and an increased association with the number of instrumented levels,residual kyphotic deformity,laminectomy,and lumbosacral fixation.Intermediate screws and anterior reconstruction were associated with a clinically relevant decreased risk of pedicle screw loosening development.Either complete or partial posterior fusion within instrumented levels was capable of decreasing instrumentation failure risk,while extensive decompression with laminectomy and at least one-level total facetectomy were associated with an increased risk of instrumentation failure.Anterior decompression does not have a negative impact on instrumentation stability.CONCLUSION Intermediate screws,anterior reconstruction and posterior tension band preservation are associated with decreased rates of instrumentation instability development.Posterior fusion is beneficial in terms of instrumentation failure prevention.
基金Supported by Jiangsu Provincial Traditional Chinese Medicine Leading Talent Training Project[Su TCM Science-Education(2023)17]National Administration of Traditional Chinese Medicine Fifth Batch of National Excellent Clinical Talent Training Project[TCM Personnel-Education(2022)1].
文摘[Objectives]To explore the clinical efficacy of Qinjin Tablet in treating unstable angina with phlegm-stasis syndrome and preliminarily explore its intervention mechanism.[Methods]Sixty unstable angina patients with phlegm-stasis syndrome were randomly divided into a treatment group and a control group(30 each).The control group received standardized Western medicine treatment,while the treatment group also took Qinjin Tablet.After a 4-week treatment,comparisons were made on improvement of angina symptoms,TCM syndrome scores,blood stasis scores,reduction/cessation of short-acting anti-angina drugs,Seattle Angina Questionnaire(SAQ)scores,blood lipid levels,and matrix metalloproteinase-9(MMP-9)concentrations between the two groups.[Results]No statistical differences existed in baseline data like age,gender,and disease duration between the two groups(P>0.05).The treatment group showed significantly better efficacy than the control group in improving angina symptoms,TCM syndrome scores,blood stasis scores,and reduction or discontinuation of short-acting anti-anginal drugs(P<0.05).The SAQ score increase was more significant in the treatment group(P<0.05).The control group significantly reduced low-density lipoprotein cholesterol(LDL-C)(P<0.05),while the treatment group markedly increased high-density lipoprotein cholesterol(HDL-C)(P<0.05).Post-treatment,the treatment group had a marked reduction in serum MMP-9(P<0.05),with no significant change in the control group.[Conclusions]Qinjin Tablet can significantly alleviate clinical symptoms and improve quality of life in UA patients by modulating the HDL-C/MMP-9 signaling pathway.
文摘Due to the coexistence of compressibility,viscosity,and threedimensional effects,laminar flow is difficult to maintain for high-speed boundary layer on complex geometries.The unstable disturbance waves in the boundary layer are excited and rapidly increase during the receptivity process,so sufficiently large Reynolds stress causes the basic flow velocity profile to change,and the formation of turbulence is inevitable.
文摘In this paper,a nonlinear control approach for an unstable networked plant in the presence of actuator and sensor limitations using robust right coprime factorization is proposed.The actuator is limited by upper and lower constraints and the sensor in the feedback loop is subjected to network-induced unknown time-varying delay and noise.With this nonlinear control method,we first employ right coprime factorization based on isomorphism and operator theory to factorize the plant,so that bounded input bounded output(BIBO)stability can be guaranteed.Next,continuous-time generalized predictive control(CGPC)is utilized for the unstable operator of the right coprime factorized plant to guarantee inner stability and enables the closed-loop dynamics of the system with predictive characteristics.Meanwhile,a second-Do F(degrees of freedom)switched controller that satisfies a perturbed Bezout identity and a robustness condition is designed.By using the CGPC controller that possesses predictive behavior and the second-Do F switched stabilizer,the overall stability of the plant subjected to actuator limitations is guaranteed.To address sensor limitations that exist in networked plants in the form of delay and noise which often cause system performance degradation,we implement an identity operator definition in the feedback loop to compensate for these adverse effects.Further,a pre-operator is designed to ensure that the plant output tracks the reference input.Finally,the effectiveness of the proposed design scheme is demonstrated by simulations.
基金Supported by the National Natural Science Foundation of China(Nos.42250710152,42192562)the Southern Laboratory of Ocean Science and Engineering(Guangdong Zhuhai)(No.SML 2020 SP 007)。
文摘Convectively unstable processes caused by dense water subsidence are common occurrences in high-latitude oceanic regions,and significantly modulate mass and heat transport and mixing processes in the ocean.An idealized numerical experiment using the large eddy simulation method was conducted to analyze the three-dimensional flow field structure and the mechanism for dense water subsidence.Specifically,a negative salt flux is set at the sea surface,in which salt flux enters the sea surface to simulate the icing and salting-out phenomena that occur at high latitudes.Results show that the mean-state 3D flow field of dense water subsidence exhibits a hollow conical distribution.The horizontal flow field is characterized by a cyclonic vortex that driven primarily by the pressure gradient and influenced by the Coriolis effect.Moreover,the inverse vertical pressure gradient generated by this vortex inhibits the sinking of the plume,leading to its off-axis deflection and the development of an anticyclonic precession.In addition,the impact of rotation on the structure of a sinking plume within a stratified environment is discussed.Both horizontal vortex intensity and cone angle of the hollow cone flow field are increased with increasing rotation rate,resulting in a decrease in the plume’s maximum sinking depth.Variances in rotation direction cause the horizontal vortex and sinking plumes of dense water in the northern and southern hemispheres to rotate in opposite directions.
文摘Objective:To evaluate and analyze the actual efficacy of percutaneous vertebroplasty in the treatment of old unstable osteoporotic spinal fractures.Methods:From March 2023 to March 2024,46 patients with old unstable osteoporotic spinal fractures in our hospital were included in this study.They were divided into the conventional group and the observation group based on treatment differences,with 23 patients in each group.The conventional group received conservative drug therapy,while the observation group underwent percutaneous vertebroplasty.The following indicators were compared and analyzed between the two groups:clinical treatment effect and improvement in physical function indicators.Results:The treatment efficiency of the observation group was 95.65%(22/23),while that of the conventional group was 69.57%(16/23).There was a significant difference between the groups,and the treatment effect of the observation group was significantly better(P<0.05).After treatment,the scores of physical status,daily living ability,functional independence,and life obstacles in the observation group were(89.33±4.08),(88.72±4.08),(90.41±2.89),(72.35±3.22),respectively,while those in the conventional group were(68.54±4.21),(67.42±4.11),(73.48±2.75),(72.35±3.22).There was a significant difference between the groups,and the improvement in physical function indicators in the observation group was more pronounced(P<0.05).Conclusion:For patients with old unstable osteoporotic spinal fractures,the basic value of percutaneous vertebroplasty is significant.It can not only improve clinical efficacy and safety but also promote the gradual recovery of patients'physical function indicators.It is recommended for clinical reference and practical application.
基金Under the auspices of National Natural Science Foundation of China(No.42171414)。
文摘Interactions among ecosystem services(ESs)are spatially heterogeneous,shaped by both stable(unidirectional)and unstable(context-dependent)influences of socio-economic development and climate change.These complexities pose significant challenges for spatially adaptive ecosystem management.Ecosystem service bundles(ESBs),as recurring combinations of ESs,offer a valuable framework to capture such interactions.Here,we proposed an integrated analytical framework that combines K-means clustering,the geographical detector(GD)model,and geographically and temporally weighted regression(GTWR)models to evaluate how socio-economic and climatic drivers influence ESBs across space and time.Using Hanshui River Basin(HRB)in central China as a case study,we quantified ES dynamics from 2000 to 2020,identified ESBs and stable and unstable effects of multiple drivers.The results showed that carbon sequestration(CS),water yield(WY),and aesthetic landscape(AL)increased by 32.80%,9.00%,and 7.34%,respectively,while soil retention(SR)and food supply(FS)declined by 8.38%and 5.36%.Five distinct ESBs were identified,namely ecologically fragile bundle(EFB),agricultural production bundle(APB),water supply bundle(WSB),forest ecological bundle(FEB),and ecological conservation bundle(ECB).Among these,FEB expanded to more than 35.75%of the HRB,and APB exhibited the sharpest decline(-28.64%).Land use intensity(LUI)was the primary driver of the spatial heterogeneity of ESBs,while synergistic and nonlinear interactions among multiple factors increasingly amplified their effects over time.Notably,annual precipitation(AP)emerged as the only stable basin-scale driver,consistently enhancing ES performance,while gross domestic product(GDP)and normalized difference vegetation index(NDVI)had stable yet spatially differentiated effects across bundles.Our findings highlight the significance of distinguishing stable/unstable driver effects on ES dynamics to inform regionally adaptive ecosystem governance.The proposed framework provides valuable insights into ES interactions,identify spatial priorities,and support policy interventions that balance ecological conservation with socio-economic development.
文摘Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and Conclusion The criteria for singular points, closed orbits and hyperbolic equilibrium points of a second order autonomous Birkhoff system are given. Moreover the stability of equilibria, stable manifolds and unstable manifolds are obtained.
基金Project (51005112) supported by the National Natural Science Foundation of ChinaProject (GF200901008) supported by the Open Fund of National Defense Key Disciplines Laboratory of Light Alloy Processing Science and Technology,China
文摘A method is proposed for prediction of the unstable deformation in hot forging process using both the determined thermomechnical parameter windows of the unstable deformation zones and finite element simulation. Taking Ti-6.5Al-3.5Mo-1.5Zr-0.3Si alloy as the testing material, the thermomechnical parameter windows of the unstable deformation zones for the Ti-alloy are integrated into a commercial finite element simulation software platform. The distribution and variation of the unstable deformation zones of the alloy in hot compression process are simulated and predicted using the tailor-made finite element codes in the finite element platform. The simulation results tally with the physical experiments and the proposed method for simulation and prediction of the unstable deformation is thus verified and its efficiency is validated.
文摘Objective Compare the morphology of atherosclerotic plaquesmgiographically and histopathologically in acute myocardialmfarction m order to accumulate experience in recognizing plaquerupture and thrombus by angiogrames.Material and methods 16postmortem cases of acute myocardial infarction were studied.The coronary arteries were romoved en block,filled with barium the lumen and ridiographed.Then the arteries wereontinuously insetted and routin HE sections were made.Results 16 cases had plaque ruptures and thrombi.Among the total98 blocks,21 had plaque ruptures on which 20 thrombiccur(95.23%).while the other 777 unrupured blocks had only 2hrombi(0.25%).The difference was significant(p【0.001).Therupture mostly occur on unstable plaques.The ruptured plaqueswith thrombi had different angiographical morphology withunruptured plaques.The former had irregular borders andunraluminal lucencies;while the Iatter had smooth borders and nointraluminal lucencies.Conclusions Plaque ruprure withthrumbus was the major cause of acute myocardial infarction andthe ruptured plaques with thrombus had different angiographicalapperances with unruptured plaques.
