This paper investigates the problem of dynamic event-triggered control for a class of large-scale nonlinear systems.In particular,both neutral delays and unknown backlash-like hysteresis are considered.This requires t...This paper investigates the problem of dynamic event-triggered control for a class of large-scale nonlinear systems.In particular,both neutral delays and unknown backlash-like hysteresis are considered.This requires to integrate a compensation mechanism into the event-triggered control architecture.To this end,dynamic gain and adaptive control techniques are introduced to address the effects of neutral delays,unknown hysteresis and parameter uncertainties simultaneously.By introducing a non-negative internal dynamic variable,a dynamic event-triggered controller is designed using the hyperbolic tangent function to reduce the communication burden.By means of the Lyapunov–Krasovskii method,it is demonstrated that all signals of the closed-loop system are globally bounded and eventually converge to a tunable bounded region.Moreover,the Zeno behavior is avoided.Finally,a simulation example is presented to verify the validity of the control scheme.展开更多
The problem of high-performance tracking controlfor the lower-triangular systems with unknown sign-switchingvirtual control coefficients as well as unmatched disturbances isinvestigated in this paper.Instead of the on...The problem of high-performance tracking controlfor the lower-triangular systems with unknown sign-switchingvirtual control coefficients as well as unmatched disturbances isinvestigated in this paper.Instead of the online estimation algorithm,the sliding mode method and the Nussbaum gain technique,a group of orientation functions are employed to handlethe unknown sign-switching virtual control coefficients.The controllaw is combined with the orientation functions and the barrierfunctions lumped in a recursive manner.It achieves outputtracking with the preassigned rate,overshoot,and accuracy.Incontrast with the existing solutions,it is effective for the nearlymodel-free case,with the requirement for information of neitherthe system nonlinearities nor their bounding functions of theplant,nor the bounds of the disturbances.In addition,our controllerexhibits significant simplicity,without parameter identification,disturbance estimation,function approximation,derivativecalculation,dynamic surfaces,or command filtering.Twosimulation examples are conducted to substantiate the efficacyand advantages of our approach.展开更多
Enhancing the stability and performance of practical control systems in the presence of nonlinearity,time delay,and uncertainty remains a significant challenge.Particularly,a class of strict-feedback nonlinear uncerta...Enhancing the stability and performance of practical control systems in the presence of nonlinearity,time delay,and uncertainty remains a significant challenge.Particularly,a class of strict-feedback nonlinear uncertain systems characterized by unknown control directions and time-varying input delay lacks comprehensive solutions.In this paper,we propose an observerbased adaptive tracking controller to address this gap.Neural networks are utilized to handle uncertainty,and a unique coordinate transformation is employed to untangle the coupling between input delay and unknown control directions.Subsequently,a new auxiliary signal counters the impact of time-varying input delay,while a Nussbaum function is introduced to solve the problem of unknown control directions.The leverage of an advanced dynamic surface control technique avoids the“complexity explosion”and reduces boundary layer errors.Synthesizing these techniques ensures that all the closed-loop signals are semi-globally uniformly ultimately bounded(SGUUB),and the tracking error converges to a small region around the origin by selecting suitable parameters.Simulation examples are provided to demonstrate the feasibility of the proposed approach.展开更多
This article presents an adaptive fault-tolerant tracking control strategy for unknown affine nonlinear systems subject to actuator faults and external disturbances.To address the hyperparameter initialization challen...This article presents an adaptive fault-tolerant tracking control strategy for unknown affine nonlinear systems subject to actuator faults and external disturbances.To address the hyperparameter initialization challenges inherent in conventional neural network training,an improved self-organizing radial basis function neural network(SRBFNN)with an input-dependent variable structure is developed.Furthermore,a novel selforganizing RBFNN-based observer is introduced to estimate system states across all dimensions.Leveraging the reconstructed states,the proposed adaptive controller effectively compensates for all uncertainties,including estimation errors in the observer,ensuring accurate state tracking with reduced control effort.The uniform ultimate boundedness of all closed-loop signals and tracking errors is rigorously established via Lyapunov stability analysis.Finally,simulations on two different nonlinear systems comprehensively validate the effectiveness and superiority of the proposed control approach.展开更多
Dear Editor,Aiming at the consensus tracking problem of a class of unknown heterogeneous nonlinear multiagent systems(MASs)with input constraints,a novel data-driven iterative learning consensus control(ILCC)protocol ...Dear Editor,Aiming at the consensus tracking problem of a class of unknown heterogeneous nonlinear multiagent systems(MASs)with input constraints,a novel data-driven iterative learning consensus control(ILCC)protocol based on zeroing neural networks(ZNNs)is proposed.First,a dynamic linearization data model(DLDM)is acquired via dynamic linearization technology(DLT).展开更多
Dear Editor,This letter investigates global stabilization of uncertain nonlinear systems via adaptive event-triggered output feedback.Uncertainties lie in both system nonlinearities and measurement sensitivity.To this...Dear Editor,This letter investigates global stabilization of uncertain nonlinear systems via adaptive event-triggered output feedback.Uncertainties lie in both system nonlinearities and measurement sensitivity.To this end,a dynamic high gain is introduced to cope with the influence of large uncertainties,the unknown measurement sensitivity and the execution error,while a time-varying threshold event-triggering mechanism is constructed to effectively exclude the Zeno phenomenon.As such,the adaptive event-triggered control ensures globally bounded and convergent of system states.The design method is demonstrated using a controlled pendulum example.展开更多
This paper investigates the detection and mitigation of coordinated cyberattacks on Load Frequency Control(LFC)systems integrated with Battery Energy Storage Systems(BESS).As renewable energy sources gain greater pene...This paper investigates the detection and mitigation of coordinated cyberattacks on Load Frequency Control(LFC)systems integrated with Battery Energy Storage Systems(BESS).As renewable energy sources gain greater penetration,power grids are becoming increasingly vulnerable to cyber threats,potentially leading to frequency instability and widespread disruptions.We model two significant attack vectors:load-altering attacks(LAAs)and false data injection attacks(FDIAs)that corrupt frequency measurements.These are analyzed for their impact on grid frequency stability in both linear and nonlinear LFC models,incorporating generation rate constraints and nonlinear loads.A coordinated attack strategy is presented,combining LAAs and FDIAs to achieve stealthiness by concealing frequency deviations from system operators,thereby maximizing disruption while evading traditional detection.To counteract these threats,we propose an Unknown Input Observer(UIO)-based detection framework for linear and nonlinear LFCs.The UIO is designed using linear matrix inequalities(LMIs)to estimate system states while isolating unknown attack inputs,enabling attack detection through monitoring measurement residuals against a predefined threshold.For mitigation,we leverage BESS capabilities with two adaptive strategies:dynamic mitigation for dynamic LAAs,which tunes BESS parameters to enhance the system’s stability margin and accelerate convergence to equilibrium;and staticmitigation for static LAAs and FDIAs.Simulations show that the UIO achieves high detection accuracy,with residuals exceeding thresholds promptly under coordinated attacks,even in nonlinear models.Mitigation strategies reduce frequency deviations by up to 80%compared to unmitigated cases,restoring stability within seconds.展开更多
For decades,the central dogma of oncology has been that a cancer’s identity is inextricably linked to its anatomical origin.This principle underpins the entire diagnostic and therapeutic framework,from histology-base...For decades,the central dogma of oncology has been that a cancer’s identity is inextricably linked to its anatomical origin.This principle underpins the entire diagnostic and therapeutic framework,from histology-based classification to site-specific treatment guidelines.Yet,this framework catastrophically fails for a substantial population of patients diagnosed with cancer of unknown primary(CUP).These patients present metastatic disease,yet their primary tumors remain elusive despite exhaustive clinical workup1.CUP,accounting for 1%-3%of all cancer diagnoses,is an enigma with devastating consequences;the median overall survival is only 2-12 months2-4.The inability to pinpoint an origin forces clinicians to rely on broad-spectrum empirical chemotherapy,such as taxane-carboplatin regimens,which have limited efficacy and exclude patients from the promise of targeted therapies and clinical trials5.CUP is not only a diagnostic challenge but also an indictment of the siloed approach to understanding malignancy:this cancer highlights the limitations of origin-based diagnostic frameworks.However,the confluence of high-dimensional biological data and advanced artificial intelligence(AI)is now poised to address this long-standing diagnostic limitation and to herald a new era for not only CUP but also oncology as a whole(Figure 1).展开更多
A novel LS-SVM control method is proposed for general unknown nonlinear systems. A linear kernel LS-SVM model is firstly developed for input/output(I/O) approximation. The LS-SVM control law is then derived directly f...A novel LS-SVM control method is proposed for general unknown nonlinear systems. A linear kernel LS-SVM model is firstly developed for input/output(I/O) approximation. The LS-SVM control law is then derived directly from this developed model without any approximation and assumption. It further proves that the control error is fully equal to the LS-SVM modeling error. This means that a desirable control performance can be achieved because the LS-SVM has been proven to have an outstanding modeling ability in the previous studies. Case studies finally demonstrate the effectiveness of the proposed LS-SVM control approach.展开更多
This paper proposes a new adaptive iterative learning control approach for a class of nonlinearly parameterized systems with unknown time-varying delay and unknown control direction.By employing the parameter separati...This paper proposes a new adaptive iterative learning control approach for a class of nonlinearly parameterized systems with unknown time-varying delay and unknown control direction.By employing the parameter separation technique and signal replacement mechanism,the approach can overcome unknown time-varying parameters and unknown time-varying delay of the nonlinear systems.By incorporating a Nussbaum-type function,the proposed approach can deal with the unknown control direction of the nonlinear systems.Based on a Lyapunov-Krasovskii-like composite energy function,the convergence of tracking error sequence is achieved in the iteration domain.Finally,two simulation examples are provided to illustrate the feasibility of the proposed control method.展开更多
This paper deals with the simultaneous estimation of states and unknown inputs for a class of Lipschitz nonlinear systems using only the measured outputs. The system is assumed to have bounded uncertainties that appea...This paper deals with the simultaneous estimation of states and unknown inputs for a class of Lipschitz nonlinear systems using only the measured outputs. The system is assumed to have bounded uncertainties that appear on both the state and output matrices. The observer design problem is formulated as a set of linear constraints which can be easily solved using linear matrix inequalities (LMI) technique. An application based on manipulator arm actuated by a direct current (DC) motor is presented to evaluate the performance of the proposed observer. The observer is applied to estimate both state and faults.展开更多
A robust delay compensator has been developed for a class of uncertain nonlinear systems with an unknown constant input delay.The control law consists of feedback terms based on the integral of past control values and...A robust delay compensator has been developed for a class of uncertain nonlinear systems with an unknown constant input delay.The control law consists of feedback terms based on the integral of past control values and a novel filtered tracking error,capable of compensating for input delays.Suitable Lyapunov-Krasovskii functionals are used to prove global uniformly ultimately bounded(GUUB)tracking,provided certain sufficient gain conditions,dependent on the bound of the delay,are satisfied.Simulation results illustrate the performance and robustness of the controller for different values of input delay.展开更多
A unknown input observer （UIO） design for a class of linear time-delay systems when the observer error can＇t completely decouple from unknown input is dealt with. A sufficient condition to its existence is presente...A unknown input observer （UIO） design for a class of linear time-delay systems when the observer error can＇t completely decouple from unknown input is dealt with. A sufficient condition to its existence is presented based on Lyapunov stability method. Design problem of the proposed observer is formulated in term of linear matrix inequalities. Two design problems of the observer with internal delay and without internal delay are formulated. Based on H∞ control theory in time-delay systems, the proposed observer is designed in term of linear matrix inequalities （LMI）. A design algorithm is proposed. The effective of the proposed approach is illustrated by a numerical example.展开更多
An adaptive decentralized asymptotic tracking control scheme is developed in this paper for a class of large-scale nonlinear systems with unknown strong interconnections,unknown time-varying parameters,and disturbance...An adaptive decentralized asymptotic tracking control scheme is developed in this paper for a class of large-scale nonlinear systems with unknown strong interconnections,unknown time-varying parameters,and disturbances.First,by employing the intrinsic properties of Gaussian functions for the interconnection terms for the first time,all extra signals in the framework of decentralized control are filtered out,thereby removing all additional assumptions imposed on the interconnec-tions,such as upper bounding functions and matching conditions.Second,by introducing two integral bounded functions,asymptotic tracking control is realized.Moreover,the nonlinear filters with the compensation terms are introduced to circumvent the issue of“explosion of complexity”.It is shown that all the closed-loop signals are bounded and the tracking errors converge to zero asymptotically.In the end,a simulation example is carried out to demonstrate the effectiveness of the proposed approach.展开更多
This paper presents a general method of the generalized projective synchronization and the parameter identification between two different chaotic systems with unknown parameters. This approach is based on Lyapunov sta...This paper presents a general method of the generalized projective synchronization and the parameter identification between two different chaotic systems with unknown parameters. This approach is based on Lyapunov stability theory, and employs a combination of feedback control and adaptive control. With this method one can achieve the generalized projective synchronization and realize the parameter identifications between almost all chaotic （hyperchaotic） systems with unknown parameters. Numerical simulations results are presented to demonstrate the effectiveness of the method.展开更多
Stochastic system state estimation subject to the unknown interference input widely exists in many fields,such as the control,communication,signal processing,and fault diagnosis.However,the research results are mostly...Stochastic system state estimation subject to the unknown interference input widely exists in many fields,such as the control,communication,signal processing,and fault diagnosis.However,the research results are mostly limited to the stochastic system in which only the dynamic state model or the measurement model concerns the individual unknown interference input,and the state model and the measurement model are both with the same unknown interference input.State estimate of the stochastic systems where the state model and the measurement model contain dual Unknown Interference inputs(dual-UI)with different physical meanings and mathematical definitions is concerned here.Firstly,the decoupling condition with the Unknown Interference input in the State model(S-UI)is shown,which introduces the decoupled system with the adjacent Measurement concerned Unknown Interference inputs(M-UI)appearing in the state model and the measurement model.Then,through defining the Differential term of the adjacent M-UI(M-UID),the equivalent system with only M-UID in the state model is obtained.Finally,considering the design freedom of the equivalent system,the decoupling filter in the minimum mean square error sense and the adaptive minimum upper filter with different applicable conditions are represented to obtain the optimal and sub-optimal state estimate,respectively.Two simulation cases verify the effectiveness and superiority compared with the traditional methods.展开更多
This paper proposes linear and nonlinear filters for a non-Gaussian dynamic system with an unknown nominal covariance of the output noise.The challenge of designing a suitable filter in the presence of an unknown cova...This paper proposes linear and nonlinear filters for a non-Gaussian dynamic system with an unknown nominal covariance of the output noise.The challenge of designing a suitable filter in the presence of an unknown covariance matrix is addressed by focusing on the output data set of the system.Considering that data generated from a Gaussian distribution exhibit ellipsoidal scattering,we first propose the weighted sum of norms(SON)clustering method that prioritizes nearby points,reduces distant point influence,and lowers computational cost.Then,by introducing the weighted maximum likelihood,we propose a semi-definite program(SDP)to detect outliers and reduce their impacts on each cluster.Detecting these weights paves the way to obtain an appropriate covariance of the output noise.Next,two filtering approaches are presented:a cluster-based robust linear filter using the maximum a posterior(MAP)estimation and a clusterbased robust nonlinear filter assuming that output noise distribution stems from some Gaussian noise resources according to the ellipsoidal clusters.At last,simulation results demonstrate the effectiveness of our proposed filtering approaches.展开更多
This article focuses on asymptotic precision motion control for electro-hydraulic axis systems under unknown time-variant parameters,mismatched and matched disturbances.Different from the traditional adaptive results ...This article focuses on asymptotic precision motion control for electro-hydraulic axis systems under unknown time-variant parameters,mismatched and matched disturbances.Different from the traditional adaptive results that are applied to dispose of unknown constant parameters only,the unique feature is that an adaptive-gain nonlinear term is introduced into the control design to handle unknown time-variant parameters.Concurrently both mismatched and matched disturbances existing in electro-hydraulic axis systems can also be addressed in this way.With skillful integration of the backstepping technique and the adaptive control,a synthesized controller framework is successfully developed for electro-hydraulic axis systems,in which the coupled interaction between parameter estimation and disturbance estimation is avoided.Accordingly,this designed controller has the capacity of low-computation costs and simpler parameter tuning when compared to the other ones that integrate the adaptive control and observer/estimator-based technique to dividually handle parameter uncertainties and disturbances.Also,a nonlinear filter is designed to eliminate the“explosion of complexity”issue existing in the classical back-stepping technique.The stability analysis uncovers that all the closed-loop signals are bounded and the asymptotic tracking performance is also assured.Finally,contrastive experiment results validate the superiority of the developed method as well.展开更多
基金supported by the National Natural Science Foundation of China under Grant 62073190the Science Center Program of National Natural Science Foundation of China under Grant 62188101.
文摘This paper investigates the problem of dynamic event-triggered control for a class of large-scale nonlinear systems.In particular,both neutral delays and unknown backlash-like hysteresis are considered.This requires to integrate a compensation mechanism into the event-triggered control architecture.To this end,dynamic gain and adaptive control techniques are introduced to address the effects of neutral delays,unknown hysteresis and parameter uncertainties simultaneously.By introducing a non-negative internal dynamic variable,a dynamic event-triggered controller is designed using the hyperbolic tangent function to reduce the communication burden.By means of the Lyapunov–Krasovskii method,it is demonstrated that all signals of the closed-loop system are globally bounded and eventually converge to a tunable bounded region.Moreover,the Zeno behavior is avoided.Finally,a simulation example is presented to verify the validity of the control scheme.
基金supported in part by the National Natural Science Foundation of China(61991404,62473089)the Research Program of the Liaoning Liaohe Laboratory(LLL23ZZ-05-01)+6 种基金the Key Research and Development Program of Liaoning Province of China(2023JH26/10200011)the 111 Project 2.0 of China(B08015)the National Key Research and Development Program of China(2022YFB3305905)the Xingliao Talent Program of Liaoning Province of China(XLYC2203130)the Natural Science Foundation of Liaoning Province of China(2024JH3/10200012,2023-MS-087)the Open Research Project of the State Key Laboratory of Industrial Control Technology of China(ICT2024B12)the Fundamental Research Funds for the Central Universities of China(N2108003,N2424004).
文摘The problem of high-performance tracking controlfor the lower-triangular systems with unknown sign-switchingvirtual control coefficients as well as unmatched disturbances isinvestigated in this paper.Instead of the online estimation algorithm,the sliding mode method and the Nussbaum gain technique,a group of orientation functions are employed to handlethe unknown sign-switching virtual control coefficients.The controllaw is combined with the orientation functions and the barrierfunctions lumped in a recursive manner.It achieves outputtracking with the preassigned rate,overshoot,and accuracy.Incontrast with the existing solutions,it is effective for the nearlymodel-free case,with the requirement for information of neitherthe system nonlinearities nor their bounding functions of theplant,nor the bounds of the disturbances.In addition,our controllerexhibits significant simplicity,without parameter identification,disturbance estimation,function approximation,derivativecalculation,dynamic surfaces,or command filtering.Twosimulation examples are conducted to substantiate the efficacyand advantages of our approach.
基金National Natural Science Foundation of China(62373102)Jiangsu Natural Science Foundation(BK20221455)Anhui Provincial Key Research and Development Project(2022i01020013)。
文摘Enhancing the stability and performance of practical control systems in the presence of nonlinearity,time delay,and uncertainty remains a significant challenge.Particularly,a class of strict-feedback nonlinear uncertain systems characterized by unknown control directions and time-varying input delay lacks comprehensive solutions.In this paper,we propose an observerbased adaptive tracking controller to address this gap.Neural networks are utilized to handle uncertainty,and a unique coordinate transformation is employed to untangle the coupling between input delay and unknown control directions.Subsequently,a new auxiliary signal counters the impact of time-varying input delay,while a Nussbaum function is introduced to solve the problem of unknown control directions.The leverage of an advanced dynamic surface control technique avoids the“complexity explosion”and reduces boundary layer errors.Synthesizing these techniques ensures that all the closed-loop signals are semi-globally uniformly ultimately bounded(SGUUB),and the tracking error converges to a small region around the origin by selecting suitable parameters.Simulation examples are provided to demonstrate the feasibility of the proposed approach.
基金supported in part by the National Natural Science Foundation of China(62033008,62188101,62173343,62073339)the Natural Science Foundation of Shandong Province of China(ZR2024MF072,ZR2022ZD34)the Research Fund for the Taishan Scholar Project of Shandong Province of China.
文摘This article presents an adaptive fault-tolerant tracking control strategy for unknown affine nonlinear systems subject to actuator faults and external disturbances.To address the hyperparameter initialization challenges inherent in conventional neural network training,an improved self-organizing radial basis function neural network(SRBFNN)with an input-dependent variable structure is developed.Furthermore,a novel selforganizing RBFNN-based observer is introduced to estimate system states across all dimensions.Leveraging the reconstructed states,the proposed adaptive controller effectively compensates for all uncertainties,including estimation errors in the observer,ensuring accurate state tracking with reduced control effort.The uniform ultimate boundedness of all closed-loop signals and tracking errors is rigorously established via Lyapunov stability analysis.Finally,simulations on two different nonlinear systems comprehensively validate the effectiveness and superiority of the proposed control approach.
基金supported by the National Nature Science Foundation of China(U21A20166)the Science and Technology Development Foundation of Jilin Province(20230508095RC)+2 种基金the Major Science and Technology Projects of Jilin Province and Changchun City(20220301033GX)the Development and Reform Commission Foundation of Jilin Province(2023C034-3)the Interdisciplinary Integration and Innovation Project of JLU(JLUXKJC2020202).
文摘Dear Editor,Aiming at the consensus tracking problem of a class of unknown heterogeneous nonlinear multiagent systems(MASs)with input constraints,a novel data-driven iterative learning consensus control(ILCC)protocol based on zeroing neural networks(ZNNs)is proposed.First,a dynamic linearization data model(DLDM)is acquired via dynamic linearization technology(DLT).
基金supported by the National Natural Science Foundation of China(62203283)Shandong Provincial Natural Science Foundation(ZR2022QF009,ZR2023QA063)the China Postdoctoral Science Foundation(2022M711981).
文摘Dear Editor,This letter investigates global stabilization of uncertain nonlinear systems via adaptive event-triggered output feedback.Uncertainties lie in both system nonlinearities and measurement sensitivity.To this end,a dynamic high gain is introduced to cope with the influence of large uncertainties,the unknown measurement sensitivity and the execution error,while a time-varying threshold event-triggering mechanism is constructed to effectively exclude the Zeno phenomenon.As such,the adaptive event-triggered control ensures globally bounded and convergent of system states.The design method is demonstrated using a controlled pendulum example.
基金supported by the Natural Science Foundation of China No.62303126the project Major Scientific and Technological Special Project of Guizhou Province([2024]014).
文摘This paper investigates the detection and mitigation of coordinated cyberattacks on Load Frequency Control(LFC)systems integrated with Battery Energy Storage Systems(BESS).As renewable energy sources gain greater penetration,power grids are becoming increasingly vulnerable to cyber threats,potentially leading to frequency instability and widespread disruptions.We model two significant attack vectors:load-altering attacks(LAAs)and false data injection attacks(FDIAs)that corrupt frequency measurements.These are analyzed for their impact on grid frequency stability in both linear and nonlinear LFC models,incorporating generation rate constraints and nonlinear loads.A coordinated attack strategy is presented,combining LAAs and FDIAs to achieve stealthiness by concealing frequency deviations from system operators,thereby maximizing disruption while evading traditional detection.To counteract these threats,we propose an Unknown Input Observer(UIO)-based detection framework for linear and nonlinear LFCs.The UIO is designed using linear matrix inequalities(LMIs)to estimate system states while isolating unknown attack inputs,enabling attack detection through monitoring measurement residuals against a predefined threshold.For mitigation,we leverage BESS capabilities with two adaptive strategies:dynamic mitigation for dynamic LAAs,which tunes BESS parameters to enhance the system’s stability margin and accelerate convergence to equilibrium;and staticmitigation for static LAAs and FDIAs.Simulations show that the UIO achieves high detection accuracy,with residuals exceeding thresholds promptly under coordinated attacks,even in nonlinear models.Mitigation strategies reduce frequency deviations by up to 80%compared to unmitigated cases,restoring stability within seconds.
基金supported by the National Natural Science Foundation of China(Grant Nos.32270688,31801117,and 82430107 to X.L.,and 32500589 to H.S.)the China Postdoctoral Science Foundation(Grant Nos.BX20240253 and 2024M762384 to H.S.)+1 种基金the Natural Science Foundation of Tianjin(Grant No.24JCQNJC01280 to H.S.)Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-3-003A).
文摘For decades,the central dogma of oncology has been that a cancer’s identity is inextricably linked to its anatomical origin.This principle underpins the entire diagnostic and therapeutic framework,from histology-based classification to site-specific treatment guidelines.Yet,this framework catastrophically fails for a substantial population of patients diagnosed with cancer of unknown primary(CUP).These patients present metastatic disease,yet their primary tumors remain elusive despite exhaustive clinical workup1.CUP,accounting for 1%-3%of all cancer diagnoses,is an enigma with devastating consequences;the median overall survival is only 2-12 months2-4.The inability to pinpoint an origin forces clinicians to rely on broad-spectrum empirical chemotherapy,such as taxane-carboplatin regimens,which have limited efficacy and exclude patients from the promise of targeted therapies and clinical trials5.CUP is not only a diagnostic challenge but also an indictment of the siloed approach to understanding malignancy:this cancer highlights the limitations of origin-based diagnostic frameworks.However,the confluence of high-dimensional biological data and advanced artificial intelligence(AI)is now poised to address this long-standing diagnostic limitation and to herald a new era for not only CUP but also oncology as a whole(Figure 1).
基金Project(51205420)supported by the National Natural Science Foundation of ChinaProject(NCET-13-0593)supported by the Program for New Century Excellent Talents in University,ChinaProject(14C0208)supported by the Research Foundation of Education Bureau of Hunan Province,China
文摘A novel LS-SVM control method is proposed for general unknown nonlinear systems. A linear kernel LS-SVM model is firstly developed for input/output(I/O) approximation. The LS-SVM control law is then derived directly from this developed model without any approximation and assumption. It further proves that the control error is fully equal to the LS-SVM modeling error. This means that a desirable control performance can be achieved because the LS-SVM has been proven to have an outstanding modeling ability in the previous studies. Case studies finally demonstrate the effectiveness of the proposed LS-SVM control approach.
基金supported by National Natural Science Foundation of China(No.60974139)Fundamental Research Funds for the Central Universities(No.72103676)
文摘This paper proposes a new adaptive iterative learning control approach for a class of nonlinearly parameterized systems with unknown time-varying delay and unknown control direction.By employing the parameter separation technique and signal replacement mechanism,the approach can overcome unknown time-varying parameters and unknown time-varying delay of the nonlinear systems.By incorporating a Nussbaum-type function,the proposed approach can deal with the unknown control direction of the nonlinear systems.Based on a Lyapunov-Krasovskii-like composite energy function,the convergence of tracking error sequence is achieved in the iteration domain.Finally,two simulation examples are provided to illustrate the feasibility of the proposed control method.
文摘This paper deals with the simultaneous estimation of states and unknown inputs for a class of Lipschitz nonlinear systems using only the measured outputs. The system is assumed to have bounded uncertainties that appear on both the state and output matrices. The observer design problem is formulated as a set of linear constraints which can be easily solved using linear matrix inequalities (LMI) technique. An application based on manipulator arm actuated by a direct current (DC) motor is presented to evaluate the performance of the proposed observer. The observer is applied to estimate both state and faults.
文摘A robust delay compensator has been developed for a class of uncertain nonlinear systems with an unknown constant input delay.The control law consists of feedback terms based on the integral of past control values and a novel filtered tracking error,capable of compensating for input delays.Suitable Lyapunov-Krasovskii functionals are used to prove global uniformly ultimately bounded(GUUB)tracking,provided certain sufficient gain conditions,dependent on the bound of the delay,are satisfied.Simulation results illustrate the performance and robustness of the controller for different values of input delay.
基金This project was supported by the National Natural Science Foundation of China(60374024)
文摘A unknown input observer （UIO） design for a class of linear time-delay systems when the observer error can＇t completely decouple from unknown input is dealt with. A sufficient condition to its existence is presented based on Lyapunov stability method. Design problem of the proposed observer is formulated in term of linear matrix inequalities. Two design problems of the observer with internal delay and without internal delay are formulated. Based on H∞ control theory in time-delay systems, the proposed observer is designed in term of linear matrix inequalities （LMI）. A design algorithm is proposed. The effective of the proposed approach is illustrated by a numerical example.
基金This work was supported in part by the National Natural Science Foundation of China(61873151,62073201)in part by the Shandong Provincial Natural Science Foundation of China(ZR2019MF009)+2 种基金the Taishan Scholar Project of Shandong Province of China(tsqn201909078)the Major Scientific and Technological Innovation Project of Shandong Province,China(2019JAZZ020812)in part by the Major Program of Shandong Province Natural Science Foundation,China(ZR2018ZB0419).
文摘An adaptive decentralized asymptotic tracking control scheme is developed in this paper for a class of large-scale nonlinear systems with unknown strong interconnections,unknown time-varying parameters,and disturbances.First,by employing the intrinsic properties of Gaussian functions for the interconnection terms for the first time,all extra signals in the framework of decentralized control are filtered out,thereby removing all additional assumptions imposed on the interconnec-tions,such as upper bounding functions and matching conditions.Second,by introducing two integral bounded functions,asymptotic tracking control is realized.Moreover,the nonlinear filters with the compensation terms are introduced to circumvent the issue of“explosion of complexity”.It is shown that all the closed-loop signals are bounded and the tracking errors converge to zero asymptotically.In the end,a simulation example is carried out to demonstrate the effectiveness of the proposed approach.
基金Project supported by the Natural Science Foundation of Hebei Province, China (Grant No A2006000128)
文摘This paper presents a general method of the generalized projective synchronization and the parameter identification between two different chaotic systems with unknown parameters. This approach is based on Lyapunov stability theory, and employs a combination of feedback control and adaptive control. With this method one can achieve the generalized projective synchronization and realize the parameter identifications between almost all chaotic （hyperchaotic） systems with unknown parameters. Numerical simulations results are presented to demonstrate the effectiveness of the method.
基金supported by the National Natural Science Foundation of China(Nos.61603040 and 61433003)Yunnan Applied Basic Research Project of China(No.201701CF00037)+1 种基金Guangdong Province Science and Technology Innovation Strategy Special Fund Project,China(No.skjtdzxrwqd2018001)Yunnan Provincial Science and Technology Department Key Research Program(Engineering),China(No.2018BA070)。
文摘Stochastic system state estimation subject to the unknown interference input widely exists in many fields,such as the control,communication,signal processing,and fault diagnosis.However,the research results are mostly limited to the stochastic system in which only the dynamic state model or the measurement model concerns the individual unknown interference input,and the state model and the measurement model are both with the same unknown interference input.State estimate of the stochastic systems where the state model and the measurement model contain dual Unknown Interference inputs(dual-UI)with different physical meanings and mathematical definitions is concerned here.Firstly,the decoupling condition with the Unknown Interference input in the State model(S-UI)is shown,which introduces the decoupled system with the adjacent Measurement concerned Unknown Interference inputs(M-UI)appearing in the state model and the measurement model.Then,through defining the Differential term of the adjacent M-UI(M-UID),the equivalent system with only M-UID in the state model is obtained.Finally,considering the design freedom of the equivalent system,the decoupling filter in the minimum mean square error sense and the adaptive minimum upper filter with different applicable conditions are represented to obtain the optimal and sub-optimal state estimate,respectively.Two simulation cases verify the effectiveness and superiority compared with the traditional methods.
基金Supported by National Natural Science Foundation of China(60374002,60674036)the Science and Technical Development Plan of Shandong Province (2004GG4204014)the Program for New Century Excellent Talents in University of China
文摘This paper proposes linear and nonlinear filters for a non-Gaussian dynamic system with an unknown nominal covariance of the output noise.The challenge of designing a suitable filter in the presence of an unknown covariance matrix is addressed by focusing on the output data set of the system.Considering that data generated from a Gaussian distribution exhibit ellipsoidal scattering,we first propose the weighted sum of norms(SON)clustering method that prioritizes nearby points,reduces distant point influence,and lowers computational cost.Then,by introducing the weighted maximum likelihood,we propose a semi-definite program(SDP)to detect outliers and reduce their impacts on each cluster.Detecting these weights paves the way to obtain an appropriate covariance of the output noise.Next,two filtering approaches are presented:a cluster-based robust linear filter using the maximum a posterior(MAP)estimation and a clusterbased robust nonlinear filter assuming that output noise distribution stems from some Gaussian noise resources according to the ellipsoidal clusters.At last,simulation results demonstrate the effectiveness of our proposed filtering approaches.
基金supported in part by the National Key R&D Program of China(No.2021YFB2011300)the National Natural Science Foundation of China(No.52075262,51905271,52275062)+1 种基金the Fok Ying-Tong Education Foundation of China(No.171044)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX22_0471)。
文摘This article focuses on asymptotic precision motion control for electro-hydraulic axis systems under unknown time-variant parameters,mismatched and matched disturbances.Different from the traditional adaptive results that are applied to dispose of unknown constant parameters only,the unique feature is that an adaptive-gain nonlinear term is introduced into the control design to handle unknown time-variant parameters.Concurrently both mismatched and matched disturbances existing in electro-hydraulic axis systems can also be addressed in this way.With skillful integration of the backstepping technique and the adaptive control,a synthesized controller framework is successfully developed for electro-hydraulic axis systems,in which the coupled interaction between parameter estimation and disturbance estimation is avoided.Accordingly,this designed controller has the capacity of low-computation costs and simpler parameter tuning when compared to the other ones that integrate the adaptive control and observer/estimator-based technique to dividually handle parameter uncertainties and disturbances.Also,a nonlinear filter is designed to eliminate the“explosion of complexity”issue existing in the classical back-stepping technique.The stability analysis uncovers that all the closed-loop signals are bounded and the asymptotic tracking performance is also assured.Finally,contrastive experiment results validate the superiority of the developed method as well.
