On March 24,the international symposium themed“Strengthen the Role of the United Nations and Promote Multilateralism”was held in Beijing.The event was hosted by the Ministry of Foreign Affairs of China,and supported...On March 24,the international symposium themed“Strengthen the Role of the United Nations and Promote Multilateralism”was held in Beijing.The event was hosted by the Ministry of Foreign Affairs of China,and supported by China Institute of International Studies(CIIS),the United Nations Association of China.展开更多
The ISO Annual Meeting 2025 was successfully held in Kigali,capital of the Republic of Rwanda,on October 6-10.The event included the opening and closing ceremonies,sessions with different themes,governance meetings an...The ISO Annual Meeting 2025 was successfully held in Kigali,capital of the Republic of Rwanda,on October 6-10.The event included the opening and closing ceremonies,sessions with different themes,governance meetings and social activities.It was hosted by Rwanda Standards Board(RSB),the ISO member,marking a historic first for East Africa.展开更多
THE world should be celebrating the creation of the United Nations(UN)80 years ago.However,its very existence is threatened.China recognizes the UN as the core of the international system.The UN Charter is a legal tre...THE world should be celebrating the creation of the United Nations(UN)80 years ago.However,its very existence is threatened.China recognizes the UN as the core of the international system.The UN Charter is a legal treaty under which national governments freely agree to uphold values and principles of behaviour.As a manifestation of the principle of“the sovereign equality of members,”each has an equal vote in the General Assembly.展开更多
In January 2025,the United States issued executive orders that could potentially curtail lesbian,gay,bisexual,transgender,queer,and other sexual and gender minorities(LGBTQ+)rights and federal aid to developing countr...In January 2025,the United States issued executive orders that could potentially curtail lesbian,gay,bisexual,transgender,queer,and other sexual and gender minorities(LGBTQ+)rights and federal aid to developing countries,such as public health programs under the United States Agency for International Development(USAID)[1,2].In the Philippines,USAID has played an important role in funding and supporting initiatives to address the country’s local HIV epidemic[2,3].展开更多
BACKGROUND Ovarian carcinoma has the highest mortality rate among all gynecological cancers.Several reproductive and hormonal risk factors,including early menarche,late menopause,limited use of oral contraceptives,and...BACKGROUND Ovarian carcinoma has the highest mortality rate among all gynecological cancers.Several reproductive and hormonal risk factors,including early menarche,late menopause,limited use of oral contraceptives,and a low pregnancy rate,have been identified as contributors to the increased susceptibility to ovarian cancer.Advancements in cancer therapy over the past century,including the emergence of precision oncology,underscore the importance of early detection and tailored interventions,factors particularly critical in ovarian cancer,where late-stage diagnosis remains a persistent barrier to survival.This challenge is compounded by the lack of a universally endorsed screening program,resulting in late-stage identification and widespread metastasis.AIM To evaluate demographic differences in ovarian cancer-related mortality from 1999 to 2020 among adult females aged≥25 years within the United States.METHODS Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database was used to collect de-identified death certificate data for malignant neoplasm of the ovaries related deaths in female adults aged 25 years and older from the year 1999 to 2020.Crude mortality rates and age-adjusted mortality rates(AAMRs)per 100000 people were calculated.Join point regression program was used to assess annual percent changes in mortality trends,with statistical significance set at P value<0.05.RESULTS Between 1999 and 2020,337619 deaths due to ovarian cancer occurred among United States females aged 25 to>85.The AAMR decreased from 14.62 in 1999 to 10.15 in 2020,with significant declines across various demographics.The AAMRs were highest among non-Hispanic White women,i.e.,13.53.Based on region,they were the highest in the Northeast(13.06)and Midwest(12.94).The steepest decline was observed in metropolitan areas as compared to nonmetropolitan ones.The study highlights significant progress in reducing ovarian cancer mortality across age,race/ethnicity,and geographic regions during this period.CONCLUSION The mortality trends for ovarian carcinoma patients showed an overall decrease,with the highest mortality rates observed among older individuals(65 to>85 years)and non-Hispanic Whites.These disparities underscore the need for equitable healthcare access and targeted policy interventions.展开更多
The United States-Japan alliance was originally formed based on the US militar y occupation of Japan but has g radually evolved into a tool for the United States to maintain its hegemony in the Asia-Pacific. Currently...The United States-Japan alliance was originally formed based on the US militar y occupation of Japan but has g radually evolved into a tool for the United States to maintain its hegemony in the Asia-Pacific. Currently, a United States-Japan “axis” is rapidly surfacing primarily through the military integration between the two countries and a latticework of alliances the United States has been building in the region and even across the globe centered around the one with Japan. The emergence of a United States-Japan “axis” is driven by the strategic interests and needs of the United States wanting to sustain its hegemony in the Asia-Pacific through permanent troop deployment and also highlights Japan's realistic calculations aimed at enhancing its international status and gaining practical benefits. This trend will catalyze adjustments in the United States-Japan relations and the functions of their alliance, bring significant changes to Japan's role in regional security, and thus have far-reaching impacts on the Asia-Pacific landscape.展开更多
Cultural rights are important human rights established by the Universal Declaration of Human Rights(UDHR)and the International Covenant on Economic,Social and Cultural Rights(ICESCR).However,they have not received due...Cultural rights are important human rights established by the Universal Declaration of Human Rights(UDHR)and the International Covenant on Economic,Social and Cultural Rights(ICESCR).However,they have not received due attention within the United Nations human rights system and related academic research.As a specialized agency within the United Nations system primarily responsible for cultural affairs,United Nations Educational,Scientific and Cultural Organization(UNESCO)has played a significant role in promoting the recognition and advocacy of cultural rights in the international community,mainly by expanding and deepening the normative connotations of cultural rights,strengthening the integration of culture and cultural rights with the United Nations’development agenda,and creating cultural heritage rights and other specific examples of protection practices.Under its leadership,the United Nations system is exploring a new agenda of collective actions to promote cultural rights,which shows a trend of emphasizing cross-sectoral collaboration between culture and science,as well as culture and education.Guided by Xi Jinping Thought on Culture,China should further leverage the advantages of UNESCO as a global cultural governance platform to share its concepts and experience in protecting and realizing cultural rights with the international community.Through the Global Civilization Initiative,China can lead and shape the emerging international agenda on cultural rights and promote the progress of international human rights and the building of a community with a shared future for mankind.展开更多
Four new^(10)Be-^(26)Al isochron burial ages ranging from 4.4 to 2 Ma on ancestral Colorado River deposits in the lower Colorado River corridor(LCRC)help constrain the river’s evolution during the Pliocene and early ...Four new^(10)Be-^(26)Al isochron burial ages ranging from 4.4 to 2 Ma on ancestral Colorado River deposits in the lower Colorado River corridor(LCRC)help constrain the river’s evolution during the Pliocene and early Pleisto-cene.They help fill a gap between previous work that focused on older and younger deposits:Older dated deposits include the 5 Ma Bouse Formation,which records the integration of the Colorado River through a series of preexisting basins to the Gulf of California and the ca.4.5-3.5 Ma Bullhead Alluvium,a 200 to 300 m thick aggregational package that immediately followed integration.The much younger,100-70 ka,Chemehuevi Formation is another major aggrada-tion package mapped throughout the LCRC.The new burial ages on the facies of Santa Fe Railway(4.37±0.71 Ma),boulder conglomerate of Bat Cave Wash(2.12±0.26 and 2.05±0.31 Ma),and the Palo Verde alluvium(3.03±0.26 Ma)partially fill in a 3.5 M.y.gap between the deposition of the Bullhead Alluvium and the Chemeheuvi Formation and document the timescales over which the Colorado River was able to remove the Bullhead aggradational package and initiate newer and smaller aggradational pulses.展开更多
The United Nations(UN)has always been a proactive promoter of mainstreaming human rights,while the Charter of the United Nations is the cornerstone and starting point for this endeavor.The mainstreaming of human right...The United Nations(UN)has always been a proactive promoter of mainstreaming human rights,while the Charter of the United Nations is the cornerstone and starting point for this endeavor.The mainstreaming of human rights is a principle and direction of UN reform,as the UN has promoted it through human rights institutions reform and institutional building.Reviewing the UN’s many years of practice in promoting the mainstreaming of human rights,it is evident that its various departments and agencies have formed a united front already,which is specifically manifested in the following ways:The UN Secretary-General puts forward reform plans to promote the mainstreaming of human rights and issues relevant initiatives and calls to action;the mechanism of mainstreaming of human rights provides institutional and financial support;the UN Development Group(later renamed the UN Sustainable Development Group)is the main platform for the UN to promote the mainstreaming of human rights;the Office of the High Commissioner for Human Rights and the Human Rights Council are the main implementing bodies for the UN to promote the mainstreaming of human rights;and other UN agencies actively respond to and implement the requirements of the mainstreaming of human rights in their respective areas of work.展开更多
Human rights education in primary and secondary schools is the initial and crucial phase of human rights education.Based on the normative documents formulated by the United Nations for human rights education during th...Human rights education in primary and secondary schools is the initial and crucial phase of human rights education.Based on the normative documents formulated by the United Nations for human rights education during this phase,this paper constructs the United Nations standards for human rights education in primary and secondary schools,which include four major aspects:educational content,educational methods,reference mechanisms,and human rights concepts.They correspond respectively to the core connotations,practical pathways,institutional protections,and spiritual pursuits of human rights education in primary and secondary schools.On the basis of critically reflecting on these standards,and in reference to the United Nations standards and in accordance with China’s actual conditions,this paper proposes the“Chinese Approach”for human rights education in primary and secondary schools:first,in terms of legislation,clear legal basis should be provided;second,in terms of administration,clear goals and action guidelines should be provided;third,in terms of resource guarantee,sufficient resource support should be provided;fourth,in terms of curriculum design,it should be suitable for Chinese primary and secondary school students;fifth,in terms of evaluation mechanism,a variety of evaluation mechanisms should be constructed.展开更多
We present a systematic summary of the geological characteristics,exploration and development history and current state of shale oil and gas in the United States.The hydrocarbon-rich shales in the major shale basins o...We present a systematic summary of the geological characteristics,exploration and development history and current state of shale oil and gas in the United States.The hydrocarbon-rich shales in the major shale basins of the United States are mainly developed in six geological periods:Middle Ordovician,Middle-Late Devonian,Early Carboniferous(Middle-Late Mississippi),Early Permian,Late Jurassic,and Late Cretaceous(Cenomanian-Turonian).Depositional environments for these shales include intra-cratonic basins,foreland basins,and passive continental margins.Paleozoic hydrocarbon-rich shales are mainly developed in six basins,including the Appalachian Basin(Utica and Marcellus shales),Anadarko Basin(Woodford Shale),Williston Basin(Bakken Shale),Arkoma Basin(Fayetteville Shale),Fort Worth Basin(Barnett Shale),and the Wolfcamp and Leonardian Spraberry/Bone Springs shale plays of the Permian Basin.The Mesozoic hydrocarbon-rich shales are mainly developed on the margins of the Gulf of Mexico Basin(Haynesville and Eagle Ford)or in various Rocky Mountain basins(Niobrara Formation,mainly in the Denver and Powder River basins).The detailed analysis of shale plays reveals that the shales are different in facies and mineral components,and"shale reservoirs"are often not shale at all.The United States is abundant in shale oil and gas,with the in-place resources exceeding 0.246×10^(12)t and 290×10^(12)m^(3),respectively.Before the emergence of horizontal well hydraulic fracturing technology to kick off the"shale revolution",the United States had experienced two decades of exploration and production practices,as well as theory and technology development.In 2007-2023,shale oil and gas production in the United States increased from approximately 11.2×10^(4)tons of oil equivalent per day(toe/d)to over 300.0×10^(4)toe/d.In 2017,the shale oil and gas production exceeded the conventional oil and gas production in the country.In 2023,the contribution from shale plays to the total U.S.oil and gas production remained above 60%.The development of shale oil and gas has largely been driven by improvements in drilling and completion technologies,with much of the recent effort focused on“cube development”or“co-development”.Other efforts to improve productivity and efficiency include refracturing,enhanced oil recovery,and drilling of“U-shaped”wells.Given the significant resources base and continued technological improvements,shale oil and gas production will continue to contribute significant volumes to total U.S.hydrocarbon production.展开更多
Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional climate.Here,we assess the performance and discuss pos...Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional climate.Here,we assess the performance and discuss possible causes of biases in a WRF-based RCM with a grid spacing of 50 km,named WRFG,from the North American Regional Climate Change Assessment Program(NARCCAP)in simulating wet season precipitation over the Central United States for a period when observational data are available.The RCM reproduces key features of the precipitation distribution characteristics during late spring to early summer,although it tends to underestimate the magnitude of precipitation.This dry bias is partially due to the model’s lack of skill in simulating nocturnal precipitation related to the lack of eastward propagating convective systems in the simulation.Inaccuracy in reproducing large-scale circulation and environmental conditions is another contributing factor.The too weak simulated pressure gradient between the Rocky Mountains and the Gulf of Mexico results in weaker southerly winds in between,leading to a reduction of warm moist air transport from the Gulf to the Central Great Plains.The simulated low-level horizontal convergence fields are less favorable for upward motion than in the NARR and hence,for the development of moist convection as well.Therefore,a careful examination of an RCM’s deficiencies and the identification of the source of errors are important when using the RCM to project precipitation changes in future climate scenarios.展开更多
This study was conducted to identify the number and density of active licensed acupuncturists(LAcs),as well as the number of accredited schools in acupuncture and Oriental medicine(AOM),as of January 1,2023,in the Uni...This study was conducted to identify the number and density of active licensed acupuncturists(LAcs),as well as the number of accredited schools in acupuncture and Oriental medicine(AOM),as of January 1,2023,in the United States(U.S.).The number of active LAcs as of January 1,2023 was 34,524,potentially33,364 after removing license duplication in multiple states,among which the largest three states were California(with 7317 LAcs[21.19%of the total]),New York(5024[14.55%])and Florida(2644[7.66%]).The total number of LAcs decreased by 8.87%from 2018,and fell short of our projected number of LAcs in 2023 by 9037,or 20.75%.The overall LAc density in the U.S.Dmeasured as the number of LAcs per 100,000 populationDwas 10.36,less than in 2018.There were 56 active,accredited AOM schools which offered a total of 147 programs(121 at the level necessary for licensing[entry-level],12 for an advanced practicing degree[advanced-level],and 14 for certifications).Broken down further,offerings included 50 master's degrees in acupuncture,40 master's degrees in Oriental medicine,31 entry-level doctorate degrees(10 in acupuncture and 21 in acupuncture plus Chinese herbal medicine),and 12advanced-level doctorate degrees in AOM.The certification programs included one in East-Asian Medical Bodywork and 13 in CHM.Among these schools in 2023,institutions in the West and East Coast states comprised 67.86%(decreased from 77.42%in 2018)of the national total.California,Florida and Illinois represented 39.29%.There were 48 jurisdictions with acupuncture practice laws in place.The data suggests that the acupuncture profession in the U.S.has been significantly impacted during the coronavirus disease 2019 pandemic.展开更多
Anthropogenic Nitrogen oxides(NO_(x)=NO_(2)+NO)emissions are highly concentrated in urban area,and the weekly cycles,seasonal patterns and long-term trends of tropospheric NO_(2) columns over cities differ from region...Anthropogenic Nitrogen oxides(NO_(x)=NO_(2)+NO)emissions are highly concentrated in urban area,and the weekly cycles,seasonal patterns and long-term trends of tropospheric NO_(2) columns over cities differ from region to region due to different emission sectoral compositions and human activities.In this study,we used satellite observed tropospheric NO_(2) column data to compare the longand short-term NO_(2) column density time series over cities in the United Sates(the U.S.),western Europe and China.The results showed that in all the targeted cities,the outbreak of the Corona Virus Disease in 2019(COVID-19)moved the December peak of the city-level NO_(2)columns forward to November and October or even earlier in 2020 and 2021.On weekly level,cities in the U.S.show the lowest NO_(2) columns ratio on weekend/work day,then come the western European cities,and a weak weekly pattern is seen in Chinese cities.For all the cites,we find a higher weekend/work day NO_(2) ratio in cold seasons than in warm seasons,indicating a higher contribution from NOx emission sectors of residential,industry and power plants in the warm seasons.In the long-term,NO_(2) columns over the U.S.and western European cities declined by a fraction twice that of the regional mean level from 2004 to 2021.In China,NO_(2) columns started to decrease since 2012,at a similar rate between the city and regional level.This work confirms the importance to quantify and control NOx emissions from cities.展开更多
BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous system.Given its low prevalence,collecting data on large cohorts of patients with WD is chal...BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous system.Given its low prevalence,collecting data on large cohorts of patients with WD is challenging.Comprehensive insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare diseases.AIM To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims database.METHODS This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product database.All patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study end.Patients were divided into two groups by whether or not they were documented to have received a specific treatment for WD.Clinical manifestations,hospital-isations,liver transplantation and death were documented.RESULTS Overall,5376 patients with an ICD-10 diagnostic code for WD were identified.The mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter purchase.At inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented treatment.During follow-up,273 patients(5.1%)died.Compared with the American general population,the standardised mortality ratio was 2.19.The proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 years.CONCLUSION Patients treated for WD in the United States had an excess early mortality compared with the American population.These findings indicate that there is a significant unmet need for effective treatment for WD in the United States.展开更多
This study evaluates the distribution of travel-limiting disabilities across genders and geographic locations in the United States. This study aims to describe and compare the socioeconomic and demographic variables o...This study evaluates the distribution of travel-limiting disabilities across genders and geographic locations in the United States. This study aims to describe and compare the socioeconomic and demographic variables of the people with and without travel-limiting disabilities across geographic locations and gender. The study further evaluates the trip purpose and impact of Covid-19 fourth wave pandemic on the use of public transit and travel to physical workplace for the people with and without travel-limiting disabilities across gender and geographic locations. The study uses the 2022 weighted National Household Travel Survey dataset and employs descriptive statistics. Results reaffirm the findings from previous literature that there are more people with travel-limiting disabilities in urban areas and among women. Over 50 percent of people aged 65 and above have a form of travel-limiting disabilities. The most trip for people with travel-limiting disabilities is made for shopping and medical purposes. Across all categories, rural areas, urban areas, male and female for the people without travel-limiting disabilities, COVID-19 fourth wave did not change the pattern of trips made to physical workplace as pre-COVID-19 era. This pattern is also observable for the people with travel-limiting disabilities in rural and urban areas. Females with travel-limiting disabilities reported making less trips to physical workplaces while male reported doing the same as before COVID-19 era. The study concludes that the quantification of travel-limiting disabilities across geographic location and gender is vital in disability study and could drive policy implementation for improved accessibility for the vulnerable population.展开更多
Research Problem: In Abu Dhabi, limited implementation of OSH Regulations contributes to the general unawareness among employees and workers about occupational hazards and safety measures, resulting in slow responsive...Research Problem: In Abu Dhabi, limited implementation of OSH Regulations contributes to the general unawareness among employees and workers about occupational hazards and safety measures, resulting in slow responsiveness toward enforcement measures and a lack of self-regulatory approaches within companies. Purpose: The purpose of this study is to examine the implementation methods practised in Abu Dhabi with those in developed countries with established OSH regulatory bodies. Methodology: Qualitative and quantitative research methods were employed to gather primary research data. Workers from various industries in Abu Dhabi were sampled on purpose and asked to respond to questionnaires and interviews on OSH protocol awareness and implementation, and circumstances of workplace incidence. Results: The findings of this study showed that the enforcement of OSH requirements in UAE positively correlated to a reduction in the rate of work-related injury and improved business performance. The quantitative research data showed that the energy sector had the highest score (15) while the tourism sector had the lowest score (5.3) in occupational health systems and improvements in business efficiency and productivity. Implications: The outcomes of this study shed light on the importance of implementing OSH Guidelines for companies to empower their safety managers to fully enforce OSH requirements in their organisations. In conclusion, effective OSH enforcement requires cooperation between general workers and OSH managers and facilitation from business owners.展开更多
Introduction: Maternal mortality rates have more than doubled in the U.S over the last two decades, making it one of the few places in the world where maternal mortality is increasing. Differences in maternal mortalit...Introduction: Maternal mortality rates have more than doubled in the U.S over the last two decades, making it one of the few places in the world where maternal mortality is increasing. Differences in maternal mortality among certain races and ethnicities are known but few studies examine maternal mortality among immigrants. Since immigrants represent 13.7% of the U.S. population, it is essential to examine immigrant subsets to understand maternal mortality among this vulnerable population. Methods: A literature search identified 318 articles on maternal mortality and immigrants, with 12 articles from the U.S. The keywords included maternal mortality, United States, migrants, asylum seekers, immigrants, and disparities. Maternal mortality statistics were obtained from the World Health Organization and Center for Disease Control. Results: Studies analyzed in this review found an overall lower maternal mortality rate among immigrant women compared to U.S.-born women, except for Hispanic immigrant women. Black women had the highest maternal mortality rate, regardless of immigration status. Conclusion: Although the literature points to lower maternal mortality among immigrants, the data is still somewhat mixed, making it challenging to draw comprehensive conclusions. Additional research examining maternal mortality among Im/migrants in the U.S. is needed to guide future training among healthcare professionals and policymakers.展开更多
文摘On March 24,the international symposium themed“Strengthen the Role of the United Nations and Promote Multilateralism”was held in Beijing.The event was hosted by the Ministry of Foreign Affairs of China,and supported by China Institute of International Studies(CIIS),the United Nations Association of China.
文摘The ISO Annual Meeting 2025 was successfully held in Kigali,capital of the Republic of Rwanda,on October 6-10.The event included the opening and closing ceremonies,sessions with different themes,governance meetings and social activities.It was hosted by Rwanda Standards Board(RSB),the ISO member,marking a historic first for East Africa.
文摘THE world should be celebrating the creation of the United Nations(UN)80 years ago.However,its very existence is threatened.China recognizes the UN as the core of the international system.The UN Charter is a legal treaty under which national governments freely agree to uphold values and principles of behaviour.As a manifestation of the principle of“the sovereign equality of members,”each has an equal vote in the General Assembly.
文摘In January 2025,the United States issued executive orders that could potentially curtail lesbian,gay,bisexual,transgender,queer,and other sexual and gender minorities(LGBTQ+)rights and federal aid to developing countries,such as public health programs under the United States Agency for International Development(USAID)[1,2].In the Philippines,USAID has played an important role in funding and supporting initiatives to address the country’s local HIV epidemic[2,3].
文摘BACKGROUND Ovarian carcinoma has the highest mortality rate among all gynecological cancers.Several reproductive and hormonal risk factors,including early menarche,late menopause,limited use of oral contraceptives,and a low pregnancy rate,have been identified as contributors to the increased susceptibility to ovarian cancer.Advancements in cancer therapy over the past century,including the emergence of precision oncology,underscore the importance of early detection and tailored interventions,factors particularly critical in ovarian cancer,where late-stage diagnosis remains a persistent barrier to survival.This challenge is compounded by the lack of a universally endorsed screening program,resulting in late-stage identification and widespread metastasis.AIM To evaluate demographic differences in ovarian cancer-related mortality from 1999 to 2020 among adult females aged≥25 years within the United States.METHODS Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database was used to collect de-identified death certificate data for malignant neoplasm of the ovaries related deaths in female adults aged 25 years and older from the year 1999 to 2020.Crude mortality rates and age-adjusted mortality rates(AAMRs)per 100000 people were calculated.Join point regression program was used to assess annual percent changes in mortality trends,with statistical significance set at P value<0.05.RESULTS Between 1999 and 2020,337619 deaths due to ovarian cancer occurred among United States females aged 25 to>85.The AAMR decreased from 14.62 in 1999 to 10.15 in 2020,with significant declines across various demographics.The AAMRs were highest among non-Hispanic White women,i.e.,13.53.Based on region,they were the highest in the Northeast(13.06)and Midwest(12.94).The steepest decline was observed in metropolitan areas as compared to nonmetropolitan ones.The study highlights significant progress in reducing ovarian cancer mortality across age,race/ethnicity,and geographic regions during this period.CONCLUSION The mortality trends for ovarian carcinoma patients showed an overall decrease,with the highest mortality rates observed among older individuals(65 to>85 years)and non-Hispanic Whites.These disparities underscore the need for equitable healthcare access and targeted policy interventions.
文摘The United States-Japan alliance was originally formed based on the US militar y occupation of Japan but has g radually evolved into a tool for the United States to maintain its hegemony in the Asia-Pacific. Currently, a United States-Japan “axis” is rapidly surfacing primarily through the military integration between the two countries and a latticework of alliances the United States has been building in the region and even across the globe centered around the one with Japan. The emergence of a United States-Japan “axis” is driven by the strategic interests and needs of the United States wanting to sustain its hegemony in the Asia-Pacific through permanent troop deployment and also highlights Japan's realistic calculations aimed at enhancing its international status and gaining practical benefits. This trend will catalyze adjustments in the United States-Japan relations and the functions of their alliance, bring significant changes to Japan's role in regional security, and thus have far-reaching impacts on the Asia-Pacific landscape.
文摘Cultural rights are important human rights established by the Universal Declaration of Human Rights(UDHR)and the International Covenant on Economic,Social and Cultural Rights(ICESCR).However,they have not received due attention within the United Nations human rights system and related academic research.As a specialized agency within the United Nations system primarily responsible for cultural affairs,United Nations Educational,Scientific and Cultural Organization(UNESCO)has played a significant role in promoting the recognition and advocacy of cultural rights in the international community,mainly by expanding and deepening the normative connotations of cultural rights,strengthening the integration of culture and cultural rights with the United Nations’development agenda,and creating cultural heritage rights and other specific examples of protection practices.Under its leadership,the United Nations system is exploring a new agenda of collective actions to promote cultural rights,which shows a trend of emphasizing cross-sectoral collaboration between culture and science,as well as culture and education.Guided by Xi Jinping Thought on Culture,China should further leverage the advantages of UNESCO as a global cultural governance platform to share its concepts and experience in protecting and realizing cultural rights with the international community.Through the Global Civilization Initiative,China can lead and shape the emerging international agenda on cultural rights and promote the progress of international human rights and the building of a community with a shared future for mankind.
文摘Four new^(10)Be-^(26)Al isochron burial ages ranging from 4.4 to 2 Ma on ancestral Colorado River deposits in the lower Colorado River corridor(LCRC)help constrain the river’s evolution during the Pliocene and early Pleisto-cene.They help fill a gap between previous work that focused on older and younger deposits:Older dated deposits include the 5 Ma Bouse Formation,which records the integration of the Colorado River through a series of preexisting basins to the Gulf of California and the ca.4.5-3.5 Ma Bullhead Alluvium,a 200 to 300 m thick aggregational package that immediately followed integration.The much younger,100-70 ka,Chemehuevi Formation is another major aggrada-tion package mapped throughout the LCRC.The new burial ages on the facies of Santa Fe Railway(4.37±0.71 Ma),boulder conglomerate of Bat Cave Wash(2.12±0.26 and 2.05±0.31 Ma),and the Palo Verde alluvium(3.03±0.26 Ma)partially fill in a 3.5 M.y.gap between the deposition of the Bullhead Alluvium and the Chemeheuvi Formation and document the timescales over which the Colorado River was able to remove the Bullhead aggradational package and initiate newer and smaller aggradational pulses.
文摘The United Nations(UN)has always been a proactive promoter of mainstreaming human rights,while the Charter of the United Nations is the cornerstone and starting point for this endeavor.The mainstreaming of human rights is a principle and direction of UN reform,as the UN has promoted it through human rights institutions reform and institutional building.Reviewing the UN’s many years of practice in promoting the mainstreaming of human rights,it is evident that its various departments and agencies have formed a united front already,which is specifically manifested in the following ways:The UN Secretary-General puts forward reform plans to promote the mainstreaming of human rights and issues relevant initiatives and calls to action;the mechanism of mainstreaming of human rights provides institutional and financial support;the UN Development Group(later renamed the UN Sustainable Development Group)is the main platform for the UN to promote the mainstreaming of human rights;the Office of the High Commissioner for Human Rights and the Human Rights Council are the main implementing bodies for the UN to promote the mainstreaming of human rights;and other UN agencies actively respond to and implement the requirements of the mainstreaming of human rights in their respective areas of work.
基金“Research on Human Rights Education in Schools in China,”a major project(Project Number 16JJD820029)funded by the National Human Rights Education and Training Base of the Ministry of Education of China.
文摘Human rights education in primary and secondary schools is the initial and crucial phase of human rights education.Based on the normative documents formulated by the United Nations for human rights education during this phase,this paper constructs the United Nations standards for human rights education in primary and secondary schools,which include four major aspects:educational content,educational methods,reference mechanisms,and human rights concepts.They correspond respectively to the core connotations,practical pathways,institutional protections,and spiritual pursuits of human rights education in primary and secondary schools.On the basis of critically reflecting on these standards,and in reference to the United Nations standards and in accordance with China’s actual conditions,this paper proposes the“Chinese Approach”for human rights education in primary and secondary schools:first,in terms of legislation,clear legal basis should be provided;second,in terms of administration,clear goals and action guidelines should be provided;third,in terms of resource guarantee,sufficient resource support should be provided;fourth,in terms of curriculum design,it should be suitable for Chinese primary and secondary school students;fifth,in terms of evaluation mechanism,a variety of evaluation mechanisms should be constructed.
基金supported by the State of Texas Advanced Resource Recovery(STARR)programthe Bureau of Economic Geology's Tight Oil Resource Assessment(TORA)Mudrock Systems Research Laboratory(MSRL)consortia。
文摘We present a systematic summary of the geological characteristics,exploration and development history and current state of shale oil and gas in the United States.The hydrocarbon-rich shales in the major shale basins of the United States are mainly developed in six geological periods:Middle Ordovician,Middle-Late Devonian,Early Carboniferous(Middle-Late Mississippi),Early Permian,Late Jurassic,and Late Cretaceous(Cenomanian-Turonian).Depositional environments for these shales include intra-cratonic basins,foreland basins,and passive continental margins.Paleozoic hydrocarbon-rich shales are mainly developed in six basins,including the Appalachian Basin(Utica and Marcellus shales),Anadarko Basin(Woodford Shale),Williston Basin(Bakken Shale),Arkoma Basin(Fayetteville Shale),Fort Worth Basin(Barnett Shale),and the Wolfcamp and Leonardian Spraberry/Bone Springs shale plays of the Permian Basin.The Mesozoic hydrocarbon-rich shales are mainly developed on the margins of the Gulf of Mexico Basin(Haynesville and Eagle Ford)or in various Rocky Mountain basins(Niobrara Formation,mainly in the Denver and Powder River basins).The detailed analysis of shale plays reveals that the shales are different in facies and mineral components,and"shale reservoirs"are often not shale at all.The United States is abundant in shale oil and gas,with the in-place resources exceeding 0.246×10^(12)t and 290×10^(12)m^(3),respectively.Before the emergence of horizontal well hydraulic fracturing technology to kick off the"shale revolution",the United States had experienced two decades of exploration and production practices,as well as theory and technology development.In 2007-2023,shale oil and gas production in the United States increased from approximately 11.2×10^(4)tons of oil equivalent per day(toe/d)to over 300.0×10^(4)toe/d.In 2017,the shale oil and gas production exceeded the conventional oil and gas production in the country.In 2023,the contribution from shale plays to the total U.S.oil and gas production remained above 60%.The development of shale oil and gas has largely been driven by improvements in drilling and completion technologies,with much of the recent effort focused on“cube development”or“co-development”.Other efforts to improve productivity and efficiency include refracturing,enhanced oil recovery,and drilling of“U-shaped”wells.Given the significant resources base and continued technological improvements,shale oil and gas production will continue to contribute significant volumes to total U.S.hydrocarbon production.
文摘Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional climate.Here,we assess the performance and discuss possible causes of biases in a WRF-based RCM with a grid spacing of 50 km,named WRFG,from the North American Regional Climate Change Assessment Program(NARCCAP)in simulating wet season precipitation over the Central United States for a period when observational data are available.The RCM reproduces key features of the precipitation distribution characteristics during late spring to early summer,although it tends to underestimate the magnitude of precipitation.This dry bias is partially due to the model’s lack of skill in simulating nocturnal precipitation related to the lack of eastward propagating convective systems in the simulation.Inaccuracy in reproducing large-scale circulation and environmental conditions is another contributing factor.The too weak simulated pressure gradient between the Rocky Mountains and the Gulf of Mexico results in weaker southerly winds in between,leading to a reduction of warm moist air transport from the Gulf to the Central Great Plains.The simulated low-level horizontal convergence fields are less favorable for upward motion than in the NARR and hence,for the development of moist convection as well.Therefore,a careful examination of an RCM’s deficiencies and the identification of the source of errors are important when using the RCM to project precipitation changes in future climate scenarios.
文摘This study was conducted to identify the number and density of active licensed acupuncturists(LAcs),as well as the number of accredited schools in acupuncture and Oriental medicine(AOM),as of January 1,2023,in the United States(U.S.).The number of active LAcs as of January 1,2023 was 34,524,potentially33,364 after removing license duplication in multiple states,among which the largest three states were California(with 7317 LAcs[21.19%of the total]),New York(5024[14.55%])and Florida(2644[7.66%]).The total number of LAcs decreased by 8.87%from 2018,and fell short of our projected number of LAcs in 2023 by 9037,or 20.75%.The overall LAc density in the U.S.Dmeasured as the number of LAcs per 100,000 populationDwas 10.36,less than in 2018.There were 56 active,accredited AOM schools which offered a total of 147 programs(121 at the level necessary for licensing[entry-level],12 for an advanced practicing degree[advanced-level],and 14 for certifications).Broken down further,offerings included 50 master's degrees in acupuncture,40 master's degrees in Oriental medicine,31 entry-level doctorate degrees(10 in acupuncture and 21 in acupuncture plus Chinese herbal medicine),and 12advanced-level doctorate degrees in AOM.The certification programs included one in East-Asian Medical Bodywork and 13 in CHM.Among these schools in 2023,institutions in the West and East Coast states comprised 67.86%(decreased from 77.42%in 2018)of the national total.California,Florida and Illinois represented 39.29%.There were 48 jurisdictions with acupuncture practice laws in place.The data suggests that the acupuncture profession in the U.S.has been significantly impacted during the coronavirus disease 2019 pandemic.
基金Under the auspices of the National Natural Science Foundation of China(No.42375106,41805098)the National Key R&D Program of China(No.2023YFB3907500)。
文摘Anthropogenic Nitrogen oxides(NO_(x)=NO_(2)+NO)emissions are highly concentrated in urban area,and the weekly cycles,seasonal patterns and long-term trends of tropospheric NO_(2) columns over cities differ from region to region due to different emission sectoral compositions and human activities.In this study,we used satellite observed tropospheric NO_(2) column data to compare the longand short-term NO_(2) column density time series over cities in the United Sates(the U.S.),western Europe and China.The results showed that in all the targeted cities,the outbreak of the Corona Virus Disease in 2019(COVID-19)moved the December peak of the city-level NO_(2)columns forward to November and October or even earlier in 2020 and 2021.On weekly level,cities in the U.S.show the lowest NO_(2) columns ratio on weekend/work day,then come the western European cities,and a weak weekly pattern is seen in Chinese cities.For all the cites,we find a higher weekend/work day NO_(2) ratio in cold seasons than in warm seasons,indicating a higher contribution from NOx emission sectors of residential,industry and power plants in the warm seasons.In the long-term,NO_(2) columns over the U.S.and western European cities declined by a fraction twice that of the regional mean level from 2004 to 2021.In China,NO_(2) columns started to decrease since 2012,at a similar rate between the city and regional level.This work confirms the importance to quantify and control NOx emissions from cities.
文摘BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous system.Given its low prevalence,collecting data on large cohorts of patients with WD is challenging.Comprehensive insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare diseases.AIM To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims database.METHODS This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product database.All patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study end.Patients were divided into two groups by whether or not they were documented to have received a specific treatment for WD.Clinical manifestations,hospital-isations,liver transplantation and death were documented.RESULTS Overall,5376 patients with an ICD-10 diagnostic code for WD were identified.The mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter purchase.At inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented treatment.During follow-up,273 patients(5.1%)died.Compared with the American general population,the standardised mortality ratio was 2.19.The proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 years.CONCLUSION Patients treated for WD in the United States had an excess early mortality compared with the American population.These findings indicate that there is a significant unmet need for effective treatment for WD in the United States.
文摘This study evaluates the distribution of travel-limiting disabilities across genders and geographic locations in the United States. This study aims to describe and compare the socioeconomic and demographic variables of the people with and without travel-limiting disabilities across geographic locations and gender. The study further evaluates the trip purpose and impact of Covid-19 fourth wave pandemic on the use of public transit and travel to physical workplace for the people with and without travel-limiting disabilities across gender and geographic locations. The study uses the 2022 weighted National Household Travel Survey dataset and employs descriptive statistics. Results reaffirm the findings from previous literature that there are more people with travel-limiting disabilities in urban areas and among women. Over 50 percent of people aged 65 and above have a form of travel-limiting disabilities. The most trip for people with travel-limiting disabilities is made for shopping and medical purposes. Across all categories, rural areas, urban areas, male and female for the people without travel-limiting disabilities, COVID-19 fourth wave did not change the pattern of trips made to physical workplace as pre-COVID-19 era. This pattern is also observable for the people with travel-limiting disabilities in rural and urban areas. Females with travel-limiting disabilities reported making less trips to physical workplaces while male reported doing the same as before COVID-19 era. The study concludes that the quantification of travel-limiting disabilities across geographic location and gender is vital in disability study and could drive policy implementation for improved accessibility for the vulnerable population.
文摘Research Problem: In Abu Dhabi, limited implementation of OSH Regulations contributes to the general unawareness among employees and workers about occupational hazards and safety measures, resulting in slow responsiveness toward enforcement measures and a lack of self-regulatory approaches within companies. Purpose: The purpose of this study is to examine the implementation methods practised in Abu Dhabi with those in developed countries with established OSH regulatory bodies. Methodology: Qualitative and quantitative research methods were employed to gather primary research data. Workers from various industries in Abu Dhabi were sampled on purpose and asked to respond to questionnaires and interviews on OSH protocol awareness and implementation, and circumstances of workplace incidence. Results: The findings of this study showed that the enforcement of OSH requirements in UAE positively correlated to a reduction in the rate of work-related injury and improved business performance. The quantitative research data showed that the energy sector had the highest score (15) while the tourism sector had the lowest score (5.3) in occupational health systems and improvements in business efficiency and productivity. Implications: The outcomes of this study shed light on the importance of implementing OSH Guidelines for companies to empower their safety managers to fully enforce OSH requirements in their organisations. In conclusion, effective OSH enforcement requires cooperation between general workers and OSH managers and facilitation from business owners.
文摘Introduction: Maternal mortality rates have more than doubled in the U.S over the last two decades, making it one of the few places in the world where maternal mortality is increasing. Differences in maternal mortality among certain races and ethnicities are known but few studies examine maternal mortality among immigrants. Since immigrants represent 13.7% of the U.S. population, it is essential to examine immigrant subsets to understand maternal mortality among this vulnerable population. Methods: A literature search identified 318 articles on maternal mortality and immigrants, with 12 articles from the U.S. The keywords included maternal mortality, United States, migrants, asylum seekers, immigrants, and disparities. Maternal mortality statistics were obtained from the World Health Organization and Center for Disease Control. Results: Studies analyzed in this review found an overall lower maternal mortality rate among immigrant women compared to U.S.-born women, except for Hispanic immigrant women. Black women had the highest maternal mortality rate, regardless of immigration status. Conclusion: Although the literature points to lower maternal mortality among immigrants, the data is still somewhat mixed, making it challenging to draw comprehensive conclusions. Additional research examining maternal mortality among Im/migrants in the U.S. is needed to guide future training among healthcare professionals and policymakers.
