Apparel exports China:The decline in exports widened from January to September(-2.4%,compared to-0.2%in January-June).Exports to the EU increased(+5.9%),though the growth rate moderated.Exports to the US saw a larger ...Apparel exports China:The decline in exports widened from January to September(-2.4%,compared to-0.2%in January-June).Exports to the EU increased(+5.9%),though the growth rate moderated.Exports to the US saw a larger contraction(January-June:-1.6%,January-September:-8.2%).While exports to ASEAN countries still fell by over 10%(-17.7%),shipments to the Philippines(+6.9%),Indonesia(+19.0%),and Cambodia(+64.9%)demonstrated stronger growth performance within the year.Regarding tariffs,on October 30,China and the US agreed to lower the rates on goods subject to additional duties(effectively reducing the average tariff rate on Chinese imports to the US from about 57%to approximately 47%,though this remains significantly higher than the 19.5%overall average rate applied to other countries).展开更多
Purpose:This study examined potential differences in strength,muscle morphology,and motor unit(MU)behavior of the abductor digiti minimi(ADM)between normal-fat(NF)and over-fat(OF)males.Methods:Dual-energy X-ray absorp...Purpose:This study examined potential differences in strength,muscle morphology,and motor unit(MU)behavior of the abductor digiti minimi(ADM)between normal-fat(NF)and over-fat(OF)males.Methods:Dual-energy X-ray absorptiometry assessed percent body fat(%BF).Ultrasonography determined muscle cross-sectional area(CSA),echo intensity(EI),and subcutaneous fat(s FAT).MU behavior was assessed during isometric muscle actions at 50%of maximal voluntary contraction(MVC)by analyzing the y-intercepts and slopes for the MU action potential amplitude(MUAPAMP)vs.recruitment threshold(RT)relationships,the A and B terms for the mean firing rate(MFR)vs.RT relationships,and normalized electromyographic amplitude(N-EMGRMS).MU firing times and waveforms were validated with reconstruct-and-test and spike trigger average procedures.Results:%BF was greater for OF(25.70%±5.40%)than NF(16.50%±2.20%;p<0.001).MVC was greater for NF(27.13±7.16)N than OF([19.89±4.96]N;p=0.014).CSA was greater for NF(2.48±0.39)cm^(2)than OF([1.95±0.47]cm^(2);p=0.011).The y-intercepts for the MUAPAMPvs.RT relationships were greater for NF(0.283±0.254)m V than OF([-0.221±0.659]m V;p=0.004).The B terms for the MFR vs.RT relationships were greater for NF(-0.024±0.003)pps/%MVC than OF([-0.031±0.009]pps/%MVC;p=0.038).N-EMGRMSwas similar between groups(p=0.463).Conclusion:Maximal strength,muscle size,and MU recruitment and firing rate patterns for a non-weight bearing muscle differed between normal-fat and over-fat males.展开更多
As a public basic course and the core general course of undergraduate education,moral education(ME)in College English is imperative.It is necessary to design specific teaching programs flexibly and creatively on the b...As a public basic course and the core general course of undergraduate education,moral education(ME)in College English is imperative.It is necessary to design specific teaching programs flexibly and creatively on the basis of fully understanding the ideas,objectives and tasks,basic principles and implementation methods of ME.This paper tries integrating literature reading into unit topic teaching as a new approach to ME in College English.The specific pathways of integration include:expansion of literary reading content,diversified teaching of literary reading,diversified media of literary reading,and diversified assessment system of literary quality.The integration of literature reading and unit topic teaching is conducive to the realization of the teaching goal of cultivating students’language ability,humanistic quality,and correct values.展开更多
Slope units are divided according to the real topography and have clear geological characteristics,making them ideal units for evaluating the susceptibility to geological disasters.Based on the results of automaticall...Slope units are divided according to the real topography and have clear geological characteristics,making them ideal units for evaluating the susceptibility to geological disasters.Based on the results of automatically and manually corrected hydrological slope unit division,the Longhua District,Shenzhen City,Guangdong Province,was selected as the study area.A total of 15 influencing factors,namely Fluctuation,slope,slope aspect,curvature,topographic witness index(TWI),stream power index(SPI),topographic roughness index(TRI),annual average rainfall,distance to water system,engineering rock group,distance to fault,land use,normalized difference vegetation index(NDVI),nighttime light,and distance to road,were selected as evaluation indicators.The information volume model(IV)and random points were used to select non-geological disaster units,and then the random forest model(RF)was used to evaluate the susceptibility to geological disasters.The automatic slope unit and the hydrological slope unit were compared and analyzed in the random forest and information volume random forest models.The results show that the area under the curve(AUC)values of the automatic slope unit evaluation results are 0.931 for the IV-RF model and 0.716 for the RF model,which are 0.6%(IV-RF model)and 1.9%(RF model)higher than those for the hydrological slope unit.Based on a comparison of the evaluation methods based on the two types of slope units,the hydrological slope unit evaluation method based on manual correction is highly subjective,is complicated to operate,and has a low evaluation accuracy,whereas the evaluation method based on automatic slope unit division is efficient and accurate,is suitable for large-scale efficient geological disaster evaluation,and can better deal with the problem of geological disaster susceptibility evaluation.展开更多
The large-scale integration of power electronic interface-based renewable energy with intermittency and uncertainty poses severe challenges for power system secure operation,especially frequency security.Determining t...The large-scale integration of power electronic interface-based renewable energy with intermittency and uncertainty poses severe challenges for power system secure operation,especially frequency security.Determining the system frequency regulation ability under contingency is an open problem.To bridge this gap,a unit commitment(UC)to concentrate solar power considering operational risk and frequency dynamic constraints(RFUC-CSP)is proposed in this paper.A concentrating solar power(CSP)plant with renewable energy characteristics and synchronous units is employed to improve renewable energy utilization and provide frequency support.Firstly,an analytical operational risk model is established to quantify the operational risk under renewable energy integration.Then,the frequency dynamic response characteristic of the system is considered to construct frequency security constraints.A novel RFUC-CSP framework is formulated by incorporating operational risk and frequency security constraints into the UC model,which can allocate operational flexibility of power systems by optimizing the admissible uncertainty level to reduce operational risk.The effectiveness of the proposed RFUC-CSP model is demonstrated by case studies on the modified IEEE 30-bus and IEEE RTS-79 system,and the cost-effectiveness of the CSP plant is quantified.展开更多
《义务教育英语课程标准(2022年版)》(以下简称“新课标”)指出,英语课程要培育学生文化意识,就要引导学生“了解不同国家的优秀文明成果,比较中外文化的异同,提高跨文化沟通与交流的能力,形成健康向上的审美情趣和正确的价值观;加深对...《义务教育英语课程标准(2022年版)》(以下简称“新课标”)指出,英语课程要培育学生文化意识,就要引导学生“了解不同国家的优秀文明成果,比较中外文化的异同,提高跨文化沟通与交流的能力,形成健康向上的审美情趣和正确的价值观;加深对中华文化的理解和认同,树立国际视野,坚定文化自信”。中华优秀传统文化是中华民族的文化精髓与精神命脉,将其有机融入英语教学,不仅是提升学生跨文化沟通能力的有力举措,更是筑牢文化自信根基的必然要求。本文以PEP教材Unit 1 What's he like?教学为例,系统探索将中国传统文化融入小学英语阅读教学的实践策略。展开更多
1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconn...1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.展开更多
The increasing penetration of renewable energy sources(RES)imposes stringent flexibility requirements on thermal power units(TPUs).Integrating molten salt thermal storage systems(MSTS)and thermal-electric coupling tec...The increasing penetration of renewable energy sources(RES)imposes stringent flexibility requirements on thermal power units(TPUs).Integrating molten salt thermal storage systems(MSTS)and thermal-electric coupling technologies into TPUs has the potential to improve their operational flexibility and regulation capability.However,existing research seldom investigates the combined effects of MSTS retrofitting and thermal-electric output coupling on short-term dispatchability,especially under rapid load variation conditions.This study proposes a comprehensive modeling and multi-timescale optimization framework for MSTS-retrofitted TPUs with rapid load variation capability,enabling coordinated thermal and electrical dispatch in both day-ahead and real-time stages.The TPU model incorporates steam heating,electric heating,MSTS charge and discharge characteristics,and ladder typer ramping constraints,enabling detailed representation of thermal-electric coupling interactions.The proposed scheduling framework consists of a day-ahead economic dispatch model and a minute-level intraday rolling optimization.In the day-ahead stage,the model maximizes operational revenue while considering flexibility reserve requirements,multi-period peak shaving,reserve allocation,and thermal-electric coupling strategies that coordinate steam and electric heating with MSTS charging and discharging.In the intraday rolling stage,real-time RES fluctuations and load variations are incorporated to update dispatch decisions,ensuring continuous power–heat balance and efficient use of stored thermal energy.Simulation results verify that thermal-electric coupling enhances the system’s capability to maintain real-time power balance,while MSTS operation effectively mitigates output fluctuations and supports stable,economical operation for addressing RES variation.展开更多
Objective:To identify the root causes of typical adverse drug events through the lens of patient experiences proposing novel strategies to mitigate preventable harm.Methods:A qualitative case study leveraging in-depth...Objective:To identify the root causes of typical adverse drug events through the lens of patient experiences proposing novel strategies to mitigate preventable harm.Methods:A qualitative case study leveraging in-depth interviews with patients and families,anchored by Interactive Patient Par ticipation Theory,to analyze 4 high-severity adverse drug events(ADE)cases.Cases were purposively sampled from 8 communities in China's National Adverse Event Monitor Center(2018-2023).Semi-structured interviews explored patient perspectives,with data analyzed via thematic coding and triangulation against clinical records.Results:Five interconnected themes emerged:(1)erosion of trust,(2)communication breakdowns,(3)information asymmetry,(4)environmental inadequacies,and(5)technological alienation.Notably,75% of participants had≤high school education,and 50% used≥7 medications daily,compounding ADE risks.Conclusions:We considered elements mentioned by theory,exploring trust,communication,information,and suppor t as the root causes.In addition,we added“adaptability to new technology”as an impor tant and necessary component.It is impor tant and necessary to analyze typical adverse drug events from the perspectives of patients.展开更多
Modular truss space deployable antennas are key for future large aperture,high precision antennas,already proven in various in-orbit applications globally.This paper introduces a design method for a tetrahedral basic ...Modular truss space deployable antennas are key for future large aperture,high precision antennas,already proven in various in-orbit applications globally.This paper introduces a design method for a tetrahedral basic unit mechanism with dual height positioning nodes.A parametric model is established,and its DOF are analyzed to confirm the mechanism's validity.The new tetrahedral basic unit mechanism constructed by this method is a single DOF mechanism and can locate different parabolic node heights.In order to further adapt to the parabolic and large aperture requirements of the deployable antenna of the truss,a combination unit and modular unit mechanism are developed based on this tetrahedral unit.The DOF and deployment characteristics of the modular unit mechanism are analyzed and validated through simulations.Various networking methods for the modular units are proposed,followed by a comprehensive performance comparison of different modular truss deployable antenna mechanisms.A prototype model of the modular unit mechanism is also developed,with deployment experiments demonstrating the mechanism's simplicity,low DOF,and large deployment ratio.The findings of this study provide a theoretical and technical basis for the future design and development of truss deployable antenna mechanisms.展开更多
The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. Th...The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.展开更多
BACKGROUND Living donor kidney transplantation is the optimal method of long-term renal replacement therapy.Minimally invasive donor nephrectomy techniques,such as robot-assisted(RALDN)and hand-assisted(HALDN)laparosc...BACKGROUND Living donor kidney transplantation is the optimal method of long-term renal replacement therapy.Minimally invasive donor nephrectomy techniques,such as robot-assisted(RALDN)and hand-assisted(HALDN)laparoscopic procedures,are well-established in high-income countries and are being increasingly adopted worldwide.Nevertheless,no studies have reported surgical outcomes of RALDN donor nephrectomy from a United Kingdom center to date.AIM To compare surgical outcomes between RALDN and HALDN laparoscopic donor nephrectomy in a United Kingdom high-volume living kidney donor transplant program.METHODS A case-control matching analysis was performed based on the following parameters:Sex,age,body mass index,procedure laterality,number of renal arteries,and previous abdominal surgeries.Key surgical outcomes,including primary warm ischemia time,operative duration,and post-operative recovery,were evaluated.RESULTS In this cohort of 140 living donors(70 RALDN vs 70 HALDN),donor and recipient outcomes were equivalent across key metrics:Pain scores,overall complication rates,readmissions,reoperations,and creatinine levels at 30 days and 1 year.Recipient long-term renal function did not differ between groups.Operative time for RALDN decreased significantly over the study period,indicating progressive improvement along the learning curve.Although RALDN was associated with a modestly longer mean warm ischaemia time(3.53 minutes vs 2.76 minutes,P<0.001)and extended hospital stay(4.21 days vs 3.17 days,P<0.001),these did not translate into any disadvantage in clinical outcomes.CONCLUSION In this first United Kingdom comparative cohort,RALDN demonstrated excellent safety and efficacy,even in the early phase of our programme,matching the outcomes of the well-established,gold-standard HALDN approach.Moreover,the pronounced learning-curve trajectory suggests considerable potential for further improvements in robotic surgical outcomes as the programme matures.展开更多
The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Int...The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Intermittent theta-burst stimulation is a repetitive transcranial magnetic stimulation that operates within the theta wave range and can either promote or inhibit cortical excitability.Previous studies have shown that intermittent theta wave stimulation has neuroprotective effects,but the underlying mechanisms remain unclear.In this study,mice subjected to middle cerebral artery occlusion/reperfusion were treated with intermittent theta-burst stimulation.The results showed that intermittent theta-burst stimulation significantly improved neurological function and motor recovery,reduced apoptosis in the peri-infarct region,and activated the PI3K/AKT/GSK3β/β-catenin signaling pathway.Additionally,intermittent theta-burst stimulation suppressed inflammation through the PI3K/AKT/GSK3βand NF-κB pathways.Notably,intermittent theta-burst stimulation strengthened A2 astrocyte-blood vessel coupling,and the effects of intermittent theta-burst stimulation were reversed by the PI3K inhibitor LY294002.These findings demonstrate that intermittent theta-burst stimulation promotes neurovascular unit remodeling and improves neurological outcomes by modulating microglia and astrocytes via the PI3K/AKT/GSK3βand NF-κB signaling pathways.展开更多
Despite advances in current anti-cancer therapies,challenges such as drug resistance,toxicity,and tumor heterogeneity persist.The limitations of traditional single-target drugs and simple combination therapies are bec...Despite advances in current anti-cancer therapies,challenges such as drug resistance,toxicity,and tumor heterogeneity persist.The limitations of traditional single-target drugs and simple combination therapies are becoming increasingly apparent1.To address these issues,a novel treatment strategy,the artificially intelligent synergistic engineered drug(AISED)paradigm,merits further exploration.This paradigm is based on the systematic engineered integration of multiple active ingredients into a unified single entity through artificial intelligence(AI).This strategy is aimed at developing new anti-cancer drug designs involving multiple ingredients,multiple molecular targets,and multiple biological effects,for multiple cancer types,thereby providing a novel theoretical paradigm for overcoming existing treatment bottlenecks.展开更多
On March 24,the international symposium themed“Strengthen the Role of the United Nations and Promote Multilateralism”was held in Beijing.The event was hosted by the Ministry of Foreign Affairs of China,and supported...On March 24,the international symposium themed“Strengthen the Role of the United Nations and Promote Multilateralism”was held in Beijing.The event was hosted by the Ministry of Foreign Affairs of China,and supported by China Institute of International Studies(CIIS),the United Nations Association of China.展开更多
Intensivists are often plagued with the challenges of managing critically ill patients in the neurocritical intensive care unit(neuro ICU);one such challenge is the level of illness and the need for sedation,inhibitin...Intensivists are often plagued with the challenges of managing critically ill patients in the neurocritical intensive care unit(neuro ICU);one such challenge is the level of illness and the need for sedation,inhibiting the provider’s ability to adequately assess the patient.Most sedatives alter neurological and physical exam findings,only compounding potential barriers to providing the best care for each patient.It is important to emphasize that even in the altered mentation of these patients,physical and neurological exams reign supreme as diagnostic tools and should be used in conjunction with multimodal neuromonitoring methods,rather than labs or imaging alone.Additionally,selecting the appropriate analgesic(s)and sedative(s)based on these findings are highly important when determining the best course of individualized management.Thus,providers in the neuro ICU should be highly familiar with the appropriate analgesic and sedative options available in order to determine not only which may be best for each patient,but to also better understand how each drug may impact assessment findings.This comprehensive review aims to provide a structured overview of the pertinent sedatives commonly used in neuro ICUs,their risks and benefits,and how providers can best utilize each in practice to further improve patient outcomes.The novel contribution of this work provides comparative drug tables,dosing guidance for pediatric and very elderly(>85-years-old)populations,and an exploration into the future possibilities of utilizing artificial intelligence and the human gut microbiome to further enhance the prospects of precision medicine.展开更多
本研究基于单元整体教学视角,旨在探索初中英语“教―学―评”一致性课堂构建策略。针对当前初中英语教学中的目标碎片化、内容割裂、评价模糊、闭环断裂等困境,文章以逆向设计与结构主义为理论支撑,以核心素养为导向,提出“目标锚定―...本研究基于单元整体教学视角,旨在探索初中英语“教―学―评”一致性课堂构建策略。针对当前初中英语教学中的目标碎片化、内容割裂、评价模糊、闭环断裂等困境,文章以逆向设计与结构主义为理论支撑,以核心素养为导向,提出“目标锚定―内容整合―标准研制―实践实施”四步策略,以重构层级化、主题化的单元目标体系。同时,本研究以“人教版”七年级上册Unit 3 My School为例进行实证检验,结果显示,上述策略能有效提升学生的语言、文化、思维、学习能力,实现核心素养的课堂转化,为教师提供可操作的单元整体教学设计指南。展开更多
BACKGROUND The need for an emergency upgrade of a hospitalized trauma patient from the floor to the trauma intensive care unit(ICU)is an unanticipated event with possible life-threatening consequences.Unplanned ICU ad...BACKGROUND The need for an emergency upgrade of a hospitalized trauma patient from the floor to the trauma intensive care unit(ICU)is an unanticipated event with possible life-threatening consequences.Unplanned ICU admissions are associated with increased morbidity and mortality and are an indicator of trauma service quality.Two different types of unplanned ICU admissions include upgrades(patients admitted to the floor then moved to the ICU)and bounce backs(patients admitted to the ICU,discharged to the floor,and then readmitted to the ICU).Previous studies have shown that geriatric trauma patients are at higher risk for unfavorable outcomes.AIM To analyze the characteristics,management and outcomes of trauma patients who had an unplanned ICU admission during their hospitalization.METHODS This institutional review board approved,retrospective cohort study examined 203 adult trauma patients with unplanned ICU admission at an urban level 1 trauma center over a six-year period(2017-2023).This included 134 upgrades and 69 bounce backs.Analyzed variables included:(1)Age;(2)Sex;(3)Comorbidities;(4)Mechanism of injury(MOI);(5)Injury severity score(ISS);(6)Glasgow Coma Scale(GCS);(7)Type of injury;(8)Transfusions;(9)Consultations;(10)Timing and reason for unplanned admission;(11)Intubations;(12)Surgical interventions;(13)ICU and hospital lengths of stay;and(14)Mortality.RESULTS Unplanned ICU admissions comprised 4.2%of total ICU admissions.Main MOI was falls.Mean age was 70.7 years,ISS was 12.8 and GCS was 13.9.Main injuries were traumatic brain injury(37.4%)and thoracic injury(21.7%),and main reason for unplanned ICU admission was respiratory complication(39.4%).The 47.3%underwent a surgical procedure and 46.8%were intubated.Average timing for unplanned ICU admission was 2.9 days.Bounce backs occurred half as often as upgrades,however had higher rates of transfusions(63.8%vs 40.3%,P=0.002),consultations(4.8 vs 3.0,P<0.001),intubations(63.8%vs 38.1%%,P=0.001),longer ICU lengths of stay(13.2 days vs 6.4 days,P<0.001)and hospital lengths of stay(26.7 days vs 13.0 days,P<0.001).Mortality was 25.6%among unplanned ICU admissions,31.9%among geriatric unplanned ICU admissions and 11.9%among all trauma ICU patients.CONCLUSION Unplanned ICU admissions constituted 4.2%of total ICU admissions.Respiratory complications were the main cause of unplanned ICU admissions.Bounce backs occurred half as often as upgrades,but were associated with worse outcomes.展开更多
文摘Apparel exports China:The decline in exports widened from January to September(-2.4%,compared to-0.2%in January-June).Exports to the EU increased(+5.9%),though the growth rate moderated.Exports to the US saw a larger contraction(January-June:-1.6%,January-September:-8.2%).While exports to ASEAN countries still fell by over 10%(-17.7%),shipments to the Philippines(+6.9%),Indonesia(+19.0%),and Cambodia(+64.9%)demonstrated stronger growth performance within the year.Regarding tariffs,on October 30,China and the US agreed to lower the rates on goods subject to additional duties(effectively reducing the average tariff rate on Chinese imports to the US from about 57%to approximately 47%,though this remains significantly higher than the 19.5%overall average rate applied to other countries).
文摘Purpose:This study examined potential differences in strength,muscle morphology,and motor unit(MU)behavior of the abductor digiti minimi(ADM)between normal-fat(NF)and over-fat(OF)males.Methods:Dual-energy X-ray absorptiometry assessed percent body fat(%BF).Ultrasonography determined muscle cross-sectional area(CSA),echo intensity(EI),and subcutaneous fat(s FAT).MU behavior was assessed during isometric muscle actions at 50%of maximal voluntary contraction(MVC)by analyzing the y-intercepts and slopes for the MU action potential amplitude(MUAPAMP)vs.recruitment threshold(RT)relationships,the A and B terms for the mean firing rate(MFR)vs.RT relationships,and normalized electromyographic amplitude(N-EMGRMS).MU firing times and waveforms were validated with reconstruct-and-test and spike trigger average procedures.Results:%BF was greater for OF(25.70%±5.40%)than NF(16.50%±2.20%;p<0.001).MVC was greater for NF(27.13±7.16)N than OF([19.89±4.96]N;p=0.014).CSA was greater for NF(2.48±0.39)cm^(2)than OF([1.95±0.47]cm^(2);p=0.011).The y-intercepts for the MUAPAMPvs.RT relationships were greater for NF(0.283±0.254)m V than OF([-0.221±0.659]m V;p=0.004).The B terms for the MFR vs.RT relationships were greater for NF(-0.024±0.003)pps/%MVC than OF([-0.031±0.009]pps/%MVC;p=0.038).N-EMGRMSwas similar between groups(p=0.463).Conclusion:Maximal strength,muscle size,and MU recruitment and firing rate patterns for a non-weight bearing muscle differed between normal-fat and over-fat males.
文摘As a public basic course and the core general course of undergraduate education,moral education(ME)in College English is imperative.It is necessary to design specific teaching programs flexibly and creatively on the basis of fully understanding the ideas,objectives and tasks,basic principles and implementation methods of ME.This paper tries integrating literature reading into unit topic teaching as a new approach to ME in College English.The specific pathways of integration include:expansion of literary reading content,diversified teaching of literary reading,diversified media of literary reading,and diversified assessment system of literary quality.The integration of literature reading and unit topic teaching is conducive to the realization of the teaching goal of cultivating students’language ability,humanistic quality,and correct values.
文摘Slope units are divided according to the real topography and have clear geological characteristics,making them ideal units for evaluating the susceptibility to geological disasters.Based on the results of automatically and manually corrected hydrological slope unit division,the Longhua District,Shenzhen City,Guangdong Province,was selected as the study area.A total of 15 influencing factors,namely Fluctuation,slope,slope aspect,curvature,topographic witness index(TWI),stream power index(SPI),topographic roughness index(TRI),annual average rainfall,distance to water system,engineering rock group,distance to fault,land use,normalized difference vegetation index(NDVI),nighttime light,and distance to road,were selected as evaluation indicators.The information volume model(IV)and random points were used to select non-geological disaster units,and then the random forest model(RF)was used to evaluate the susceptibility to geological disasters.The automatic slope unit and the hydrological slope unit were compared and analyzed in the random forest and information volume random forest models.The results show that the area under the curve(AUC)values of the automatic slope unit evaluation results are 0.931 for the IV-RF model and 0.716 for the RF model,which are 0.6%(IV-RF model)and 1.9%(RF model)higher than those for the hydrological slope unit.Based on a comparison of the evaluation methods based on the two types of slope units,the hydrological slope unit evaluation method based on manual correction is highly subjective,is complicated to operate,and has a low evaluation accuracy,whereas the evaluation method based on automatic slope unit division is efficient and accurate,is suitable for large-scale efficient geological disaster evaluation,and can better deal with the problem of geological disaster susceptibility evaluation.
基金supported by the National Natural Science Foundation of China General Program(No.52277106)the Project funded by China Postdoctoral Science Foundation(No.2022M721773).
文摘The large-scale integration of power electronic interface-based renewable energy with intermittency and uncertainty poses severe challenges for power system secure operation,especially frequency security.Determining the system frequency regulation ability under contingency is an open problem.To bridge this gap,a unit commitment(UC)to concentrate solar power considering operational risk and frequency dynamic constraints(RFUC-CSP)is proposed in this paper.A concentrating solar power(CSP)plant with renewable energy characteristics and synchronous units is employed to improve renewable energy utilization and provide frequency support.Firstly,an analytical operational risk model is established to quantify the operational risk under renewable energy integration.Then,the frequency dynamic response characteristic of the system is considered to construct frequency security constraints.A novel RFUC-CSP framework is formulated by incorporating operational risk and frequency security constraints into the UC model,which can allocate operational flexibility of power systems by optimizing the admissible uncertainty level to reduce operational risk.The effectiveness of the proposed RFUC-CSP model is demonstrated by case studies on the modified IEEE 30-bus and IEEE RTS-79 system,and the cost-effectiveness of the CSP plant is quantified.
文摘《义务教育英语课程标准(2022年版)》(以下简称“新课标”)指出,英语课程要培育学生文化意识,就要引导学生“了解不同国家的优秀文明成果,比较中外文化的异同,提高跨文化沟通与交流的能力,形成健康向上的审美情趣和正确的价值观;加深对中华文化的理解和认同,树立国际视野,坚定文化自信”。中华优秀传统文化是中华民族的文化精髓与精神命脉,将其有机融入英语教学,不仅是提升学生跨文化沟通能力的有力举措,更是筑牢文化自信根基的必然要求。本文以PEP教材Unit 1 What's he like?教学为例,系统探索将中国传统文化融入小学英语阅读教学的实践策略。
文摘1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.
基金funded by State Grid Jiangsu Electric Power Co.,Ltd.Science and Technology Project,grant number J2023118.
文摘The increasing penetration of renewable energy sources(RES)imposes stringent flexibility requirements on thermal power units(TPUs).Integrating molten salt thermal storage systems(MSTS)and thermal-electric coupling technologies into TPUs has the potential to improve their operational flexibility and regulation capability.However,existing research seldom investigates the combined effects of MSTS retrofitting and thermal-electric output coupling on short-term dispatchability,especially under rapid load variation conditions.This study proposes a comprehensive modeling and multi-timescale optimization framework for MSTS-retrofitted TPUs with rapid load variation capability,enabling coordinated thermal and electrical dispatch in both day-ahead and real-time stages.The TPU model incorporates steam heating,electric heating,MSTS charge and discharge characteristics,and ladder typer ramping constraints,enabling detailed representation of thermal-electric coupling interactions.The proposed scheduling framework consists of a day-ahead economic dispatch model and a minute-level intraday rolling optimization.In the day-ahead stage,the model maximizes operational revenue while considering flexibility reserve requirements,multi-period peak shaving,reserve allocation,and thermal-electric coupling strategies that coordinate steam and electric heating with MSTS charging and discharging.In the intraday rolling stage,real-time RES fluctuations and load variations are incorporated to update dispatch decisions,ensuring continuous power–heat balance and efficient use of stored thermal energy.Simulation results verify that thermal-electric coupling enhances the system’s capability to maintain real-time power balance,while MSTS operation effectively mitigates output fluctuations and supports stable,economical operation for addressing RES variation.
基金supported by the Science and Technology Fund Project of Guizhou Health Commission(gzwkj2025-163)。
文摘Objective:To identify the root causes of typical adverse drug events through the lens of patient experiences proposing novel strategies to mitigate preventable harm.Methods:A qualitative case study leveraging in-depth interviews with patients and families,anchored by Interactive Patient Par ticipation Theory,to analyze 4 high-severity adverse drug events(ADE)cases.Cases were purposively sampled from 8 communities in China's National Adverse Event Monitor Center(2018-2023).Semi-structured interviews explored patient perspectives,with data analyzed via thematic coding and triangulation against clinical records.Results:Five interconnected themes emerged:(1)erosion of trust,(2)communication breakdowns,(3)information asymmetry,(4)environmental inadequacies,and(5)technological alienation.Notably,75% of participants had≤high school education,and 50% used≥7 medications daily,compounding ADE risks.Conclusions:We considered elements mentioned by theory,exploring trust,communication,information,and suppor t as the root causes.In addition,we added“adaptability to new technology”as an impor tant and necessary component.It is impor tant and necessary to analyze typical adverse drug events from the perspectives of patients.
基金sponsored by the National Natural Science Foundation of China(No.52075467)Hebei Province Fund Outstanding Youth Fund Project,China(No.E2024203107)。
文摘Modular truss space deployable antennas are key for future large aperture,high precision antennas,already proven in various in-orbit applications globally.This paper introduces a design method for a tetrahedral basic unit mechanism with dual height positioning nodes.A parametric model is established,and its DOF are analyzed to confirm the mechanism's validity.The new tetrahedral basic unit mechanism constructed by this method is a single DOF mechanism and can locate different parabolic node heights.In order to further adapt to the parabolic and large aperture requirements of the deployable antenna of the truss,a combination unit and modular unit mechanism are developed based on this tetrahedral unit.The DOF and deployment characteristics of the modular unit mechanism are analyzed and validated through simulations.Various networking methods for the modular units are proposed,followed by a comprehensive performance comparison of different modular truss deployable antenna mechanisms.A prototype model of the modular unit mechanism is also developed,with deployment experiments demonstrating the mechanism's simplicity,low DOF,and large deployment ratio.The findings of this study provide a theoretical and technical basis for the future design and development of truss deployable antenna mechanisms.
文摘The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.
文摘BACKGROUND Living donor kidney transplantation is the optimal method of long-term renal replacement therapy.Minimally invasive donor nephrectomy techniques,such as robot-assisted(RALDN)and hand-assisted(HALDN)laparoscopic procedures,are well-established in high-income countries and are being increasingly adopted worldwide.Nevertheless,no studies have reported surgical outcomes of RALDN donor nephrectomy from a United Kingdom center to date.AIM To compare surgical outcomes between RALDN and HALDN laparoscopic donor nephrectomy in a United Kingdom high-volume living kidney donor transplant program.METHODS A case-control matching analysis was performed based on the following parameters:Sex,age,body mass index,procedure laterality,number of renal arteries,and previous abdominal surgeries.Key surgical outcomes,including primary warm ischemia time,operative duration,and post-operative recovery,were evaluated.RESULTS In this cohort of 140 living donors(70 RALDN vs 70 HALDN),donor and recipient outcomes were equivalent across key metrics:Pain scores,overall complication rates,readmissions,reoperations,and creatinine levels at 30 days and 1 year.Recipient long-term renal function did not differ between groups.Operative time for RALDN decreased significantly over the study period,indicating progressive improvement along the learning curve.Although RALDN was associated with a modestly longer mean warm ischaemia time(3.53 minutes vs 2.76 minutes,P<0.001)and extended hospital stay(4.21 days vs 3.17 days,P<0.001),these did not translate into any disadvantage in clinical outcomes.CONCLUSION In this first United Kingdom comparative cohort,RALDN demonstrated excellent safety and efficacy,even in the early phase of our programme,matching the outcomes of the well-established,gold-standard HALDN approach.Moreover,the pronounced learning-curve trajectory suggests considerable potential for further improvements in robotic surgical outcomes as the programme matures.
基金supported by the National Key R&D Program of China,Nos.2021ZD0202805(to XX),2019YFA0709504(to XX)the National Natural Science Foundation of China,Nos.82172544(to YW),32471083(to XX),81972140(to JW),82272604(to HX),82102491(to SC)+1 种基金the Brain Science and Brain-Like Research Project of Shanghai Sixth People’s Hospital,No.ynnkxyb202410(to JZ)Shanghai Science and Technology Committee Sailing Program,No.23YF1403800(to LL).
文摘The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Intermittent theta-burst stimulation is a repetitive transcranial magnetic stimulation that operates within the theta wave range and can either promote or inhibit cortical excitability.Previous studies have shown that intermittent theta wave stimulation has neuroprotective effects,but the underlying mechanisms remain unclear.In this study,mice subjected to middle cerebral artery occlusion/reperfusion were treated with intermittent theta-burst stimulation.The results showed that intermittent theta-burst stimulation significantly improved neurological function and motor recovery,reduced apoptosis in the peri-infarct region,and activated the PI3K/AKT/GSK3β/β-catenin signaling pathway.Additionally,intermittent theta-burst stimulation suppressed inflammation through the PI3K/AKT/GSK3βand NF-κB pathways.Notably,intermittent theta-burst stimulation strengthened A2 astrocyte-blood vessel coupling,and the effects of intermittent theta-burst stimulation were reversed by the PI3K inhibitor LY294002.These findings demonstrate that intermittent theta-burst stimulation promotes neurovascular unit remodeling and improves neurological outcomes by modulating microglia and astrocytes via the PI3K/AKT/GSK3βand NF-κB signaling pathways.
文摘Despite advances in current anti-cancer therapies,challenges such as drug resistance,toxicity,and tumor heterogeneity persist.The limitations of traditional single-target drugs and simple combination therapies are becoming increasingly apparent1.To address these issues,a novel treatment strategy,the artificially intelligent synergistic engineered drug(AISED)paradigm,merits further exploration.This paradigm is based on the systematic engineered integration of multiple active ingredients into a unified single entity through artificial intelligence(AI).This strategy is aimed at developing new anti-cancer drug designs involving multiple ingredients,multiple molecular targets,and multiple biological effects,for multiple cancer types,thereby providing a novel theoretical paradigm for overcoming existing treatment bottlenecks.
文摘On March 24,the international symposium themed“Strengthen the Role of the United Nations and Promote Multilateralism”was held in Beijing.The event was hosted by the Ministry of Foreign Affairs of China,and supported by China Institute of International Studies(CIIS),the United Nations Association of China.
文摘Intensivists are often plagued with the challenges of managing critically ill patients in the neurocritical intensive care unit(neuro ICU);one such challenge is the level of illness and the need for sedation,inhibiting the provider’s ability to adequately assess the patient.Most sedatives alter neurological and physical exam findings,only compounding potential barriers to providing the best care for each patient.It is important to emphasize that even in the altered mentation of these patients,physical and neurological exams reign supreme as diagnostic tools and should be used in conjunction with multimodal neuromonitoring methods,rather than labs or imaging alone.Additionally,selecting the appropriate analgesic(s)and sedative(s)based on these findings are highly important when determining the best course of individualized management.Thus,providers in the neuro ICU should be highly familiar with the appropriate analgesic and sedative options available in order to determine not only which may be best for each patient,but to also better understand how each drug may impact assessment findings.This comprehensive review aims to provide a structured overview of the pertinent sedatives commonly used in neuro ICUs,their risks and benefits,and how providers can best utilize each in practice to further improve patient outcomes.The novel contribution of this work provides comparative drug tables,dosing guidance for pediatric and very elderly(>85-years-old)populations,and an exploration into the future possibilities of utilizing artificial intelligence and the human gut microbiome to further enhance the prospects of precision medicine.
文摘本研究基于单元整体教学视角,旨在探索初中英语“教―学―评”一致性课堂构建策略。针对当前初中英语教学中的目标碎片化、内容割裂、评价模糊、闭环断裂等困境,文章以逆向设计与结构主义为理论支撑,以核心素养为导向,提出“目标锚定―内容整合―标准研制―实践实施”四步策略,以重构层级化、主题化的单元目标体系。同时,本研究以“人教版”七年级上册Unit 3 My School为例进行实证检验,结果显示,上述策略能有效提升学生的语言、文化、思维、学习能力,实现核心素养的课堂转化,为教师提供可操作的单元整体教学设计指南。
文摘BACKGROUND The need for an emergency upgrade of a hospitalized trauma patient from the floor to the trauma intensive care unit(ICU)is an unanticipated event with possible life-threatening consequences.Unplanned ICU admissions are associated with increased morbidity and mortality and are an indicator of trauma service quality.Two different types of unplanned ICU admissions include upgrades(patients admitted to the floor then moved to the ICU)and bounce backs(patients admitted to the ICU,discharged to the floor,and then readmitted to the ICU).Previous studies have shown that geriatric trauma patients are at higher risk for unfavorable outcomes.AIM To analyze the characteristics,management and outcomes of trauma patients who had an unplanned ICU admission during their hospitalization.METHODS This institutional review board approved,retrospective cohort study examined 203 adult trauma patients with unplanned ICU admission at an urban level 1 trauma center over a six-year period(2017-2023).This included 134 upgrades and 69 bounce backs.Analyzed variables included:(1)Age;(2)Sex;(3)Comorbidities;(4)Mechanism of injury(MOI);(5)Injury severity score(ISS);(6)Glasgow Coma Scale(GCS);(7)Type of injury;(8)Transfusions;(9)Consultations;(10)Timing and reason for unplanned admission;(11)Intubations;(12)Surgical interventions;(13)ICU and hospital lengths of stay;and(14)Mortality.RESULTS Unplanned ICU admissions comprised 4.2%of total ICU admissions.Main MOI was falls.Mean age was 70.7 years,ISS was 12.8 and GCS was 13.9.Main injuries were traumatic brain injury(37.4%)and thoracic injury(21.7%),and main reason for unplanned ICU admission was respiratory complication(39.4%).The 47.3%underwent a surgical procedure and 46.8%were intubated.Average timing for unplanned ICU admission was 2.9 days.Bounce backs occurred half as often as upgrades,however had higher rates of transfusions(63.8%vs 40.3%,P=0.002),consultations(4.8 vs 3.0,P<0.001),intubations(63.8%vs 38.1%%,P=0.001),longer ICU lengths of stay(13.2 days vs 6.4 days,P<0.001)and hospital lengths of stay(26.7 days vs 13.0 days,P<0.001).Mortality was 25.6%among unplanned ICU admissions,31.9%among geriatric unplanned ICU admissions and 11.9%among all trauma ICU patients.CONCLUSION Unplanned ICU admissions constituted 4.2%of total ICU admissions.Respiratory complications were the main cause of unplanned ICU admissions.Bounce backs occurred half as often as upgrades,but were associated with worse outcomes.
