Sometimes you lose something.Itmaybeakeyoryourphone.Thenyou haveto look for it.Youcan lookinmanyplaces.Itmaybeinapocketor in adrawer.Youcan also look onthings.Itmay beonadeskora table.You may also need to look underth...Sometimes you lose something.Itmaybeakeyoryourphone.Thenyou haveto look for it.Youcan lookinmanyplaces.Itmaybeinapocketor in adrawer.Youcan also look onthings.Itmay beonadeskora table.You may also need to look underthings.Look between things,too.Itmay be between two books ortwosheets of paper.Or it may be nextto yourbed or your backpack.Lookcarefully.Youcan find it!展开更多
Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer.Methods:Thirteen patients with locally advan...Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer.Methods:Thirteen patients with locally advanced cervical cancer who had been proved by pathobiology were randomly divided into two groups:the ultraselection uterine artery group(group A, n = 6) and the peripheral vein(group B, n = 7).Carboplatin was administered by infusing into artery or vein in both groups at the dosage of 300 mg/m2.Tissues from the cervical tumor were collected at different times after infusion in both groups and then analyzed.Results:The peak concentration of platinum in tumor tissue was about 2.79 times higher in group A than that of group B(P < 0.05).The platinum concentrations in tumor in group A reached its peak levels immediately after infusion.But, group B had delayed time.While, for the time point of 0 min, when the administration finished immediately, the platinum concentration in tumor was significantly higher when compared with group B(P < 0.05).The tumor tissue area under the concentration(AUC) of carboplatin was about 2 times higher in group A than that of group B(P < 0.05).Conclusion:We observed the pharmacological advantages of chemotherapy by using ultraselection uterine artery administration of chemotherapeutic agent carboplatin in tumor tissue which provided theoretical basis and laboratory parameters of the intra-arterial chemotherapy for gynecologic malignancy.展开更多
At the Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC）, the Decision of the Central Committee of the CPC on Some Major Issues concerning Deepening the Rule of Law 2014 was ...At the Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC）, the Decision of the Central Committee of the CPC on Some Major Issues concerning Deepening the Rule of Law 2014 was passed and delineated the direction for the research of our nation＇s construction of a government under the rule of law. For years, the government at various levels and administrative agencies adhered to conducting work on the legal course under the CPC＇s leadership, actively promoting administration according to law, and constructing a government under the rule of law, and have made enormous achievements. However, there many difficulties still co-exist, along with challenges and opportunities. By adopting theoretical and empirical research approaches such as data analysis, normative analysis, interviews and investigations, questionnaires, counter-measure research, and case studies, this article discusses and conducted systematic and in-depth research on the theoretical framework of the construction of a government under the rule of law from macroscopic, to microscopic aspects. This article outlined the basic contexts and realistic vision for China＇s construction of a government under the rule of law, which can provide active implementation of the project of construction of government under the rule of law with a basis in theoretical referenee.展开更多
文摘Sometimes you lose something.Itmaybeakeyoryourphone.Thenyou haveto look for it.Youcan lookinmanyplaces.Itmaybeinapocketor in adrawer.Youcan also look onthings.Itmay beonadeskora table.You may also need to look underthings.Look between things,too.Itmay be between two books ortwosheets of paper.Or it may be nextto yourbed or your backpack.Lookcarefully.Youcan find it!
基金Supported by a grant from the Nature Sciences of Guangdong Province(No. 06024389).
文摘Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer.Methods:Thirteen patients with locally advanced cervical cancer who had been proved by pathobiology were randomly divided into two groups:the ultraselection uterine artery group(group A, n = 6) and the peripheral vein(group B, n = 7).Carboplatin was administered by infusing into artery or vein in both groups at the dosage of 300 mg/m2.Tissues from the cervical tumor were collected at different times after infusion in both groups and then analyzed.Results:The peak concentration of platinum in tumor tissue was about 2.79 times higher in group A than that of group B(P < 0.05).The platinum concentrations in tumor in group A reached its peak levels immediately after infusion.But, group B had delayed time.While, for the time point of 0 min, when the administration finished immediately, the platinum concentration in tumor was significantly higher when compared with group B(P < 0.05).The tumor tissue area under the concentration(AUC) of carboplatin was about 2 times higher in group A than that of group B(P < 0.05).Conclusion:We observed the pharmacological advantages of chemotherapy by using ultraselection uterine artery administration of chemotherapeutic agent carboplatin in tumor tissue which provided theoretical basis and laboratory parameters of the intra-arterial chemotherapy for gynecologic malignancy.
文摘At the Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC）, the Decision of the Central Committee of the CPC on Some Major Issues concerning Deepening the Rule of Law 2014 was passed and delineated the direction for the research of our nation＇s construction of a government under the rule of law. For years, the government at various levels and administrative agencies adhered to conducting work on the legal course under the CPC＇s leadership, actively promoting administration according to law, and constructing a government under the rule of law, and have made enormous achievements. However, there many difficulties still co-exist, along with challenges and opportunities. By adopting theoretical and empirical research approaches such as data analysis, normative analysis, interviews and investigations, questionnaires, counter-measure research, and case studies, this article discusses and conducted systematic and in-depth research on the theoretical framework of the construction of a government under the rule of law from macroscopic, to microscopic aspects. This article outlined the basic contexts and realistic vision for China＇s construction of a government under the rule of law, which can provide active implementation of the project of construction of government under the rule of law with a basis in theoretical referenee.
