The systemic treatment of advanced mucosal melanoma(MM)is largely extrapolated from approaches within landmark melanoma clinical trials in which non-cutaneous subtypes are poorly represented.Relevant data are often de...The systemic treatment of advanced mucosal melanoma(MM)is largely extrapolated from approaches within landmark melanoma clinical trials in which non-cutaneous subtypes are poorly represented.Relevant data are often derived from underpowered subgroup analyses that fail to capture the genetic,microenvironmental and immunological differences of this distinct entity,which,alongside later presentation,likely drive its poorer outcomes relative to cutaneous disease.展开更多
文摘The systemic treatment of advanced mucosal melanoma(MM)is largely extrapolated from approaches within landmark melanoma clinical trials in which non-cutaneous subtypes are poorly represented.Relevant data are often derived from underpowered subgroup analyses that fail to capture the genetic,microenvironmental and immunological differences of this distinct entity,which,alongside later presentation,likely drive its poorer outcomes relative to cutaneous disease.
