Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method...Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method.GDM diagnosis was based on a 75-g,2-h oral glucose tolerance test(OGTT)according to the criteria of the International Association of Diabetes and Pregnancy Study Groups.Logistic regression was applied to calculate the odds ratios(ORs)and 95%confidence intervals(CIs)between ABO blood types and GDM risk.Results A total of 30,740 pregnant women with a mean age of 31.81 years were enrolled in this study.The ABO blood types distribution was:type O(30.99%),type A(26.58%),type B(32.20%),and type AB(10.23%).GDM was identified in 14.44%of participants.Using blood type O as a reference,GDM risk was not significantly higher for types A(OR=1.05)or B(OR=1.04).However,women with type AB had a 19%increased risk of GDM(OR=1.19,95%CI=1.05–1.34;P<0.05),even after adjusting for various factors.This increased risk for type AB was consistent across subgroup and sensitivity analyses.Conclusion The ABO blood types may influence GDM risk,with type AB associated with a higher risk.Incorporating it—either as a single risk factor or in combination with other known factors—could help identify individuals at risk for GDM before or during early pregnancy.展开更多
BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features ...BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.展开更多
Asian rice comprises two major subspecies:Xian(X)and Geng(G),and the diverged resistance genes(R)have provided a foundation for breeding improved cultivars to control rice blast disease.After conducting two-phase alle...Asian rice comprises two major subspecies:Xian(X)and Geng(G),and the diverged resistance genes(R)have provided a foundation for breeding improved cultivars to control rice blast disease.After conducting two-phase allele mining using six updated FNP marker systems,the functional haplotypes at Pit,Pib,and Pi63 strictly diverged into the X-populations and were defined as X-R loci,while those at Pi54,Pi37,and Pi36 into the G-populations as G-R loci.The genic diversity at the three X-R loci(16 alleles)was twofold higher than that at the three G-R loci(8 alleles),and the allelic diversity in the Southern region(21 alleles)was nearly double that in the Northeastern region(11 alleles).Both observations reflect a significant difference in genetic diversity between X-and G-populations,and indicate that the effective R-genes mainly originated from X-subspecies.Based on the allelic structures characterized by a set of 10 parameters,8 and 16 alleles were respectively recognized as favorable and promising ones for the regional breeding programs.The genotypic structures of the two regional populations were almost different,indicating that the diverged alleles have been further assembled into two series of regional genotypes through long-term breeding programs,despite the presence of one-third of region-common alleles.The genotypic diversity in the Southern region(55 genotypes)was nearly twice as high as that in the Northeastern region(28),which perfectly reflects the aforementioned differences in both genic and allelic diversities.After analyzing the genotypic structures using a set of 13 parameters,4 and 23 genotypes,respectively,can be recommended as the favorable and promising ones for the regional breeding programs.The case study serves as a concrete sample of how to identify the favorable and promising alleles and genotypes,and beneficial parents based their comprehensive population structures for gene-designed breeding.展开更多
Cloud type profoundly affects precipitation,but few studies have explored its impact on precipitation scale height.The authors calculated the ratio of the volume of each cloud type to the total cloud volume and partit...Cloud type profoundly affects precipitation,but few studies have explored its impact on precipitation scale height.The authors calculated the ratio of the volume of each cloud type to the total cloud volume and partitioned the tropical region based on the dominant cloud types.Based on this,tropical regions were categorized into altocumulus control regions,stratocumulus control regions,deep convective cloud control regions,and transition regions.These regions exhibit unique characteristics:high precipitation scale heights and low surface precipitation rates in altocumulus control regions;low precipitation scale heights and low surface precipitation rates in stratocumulus control regions;and moderate precipitation scale heights with high surface precipitation rates in deep convective cloud regions.These features arise from differences in cloud characteristics,precipitation probability,and intensity,influenced by varying water vapor structures.In terms of physical mechanisms,altocumulus,stratocumulus,and deep convective cloud regions are characterized by total dryness,upper-level dryness with lower-level wetness,and total wetness,respectively.Upper-layer dryness leads to low cloud and precipitation structures,reducing the precipitation scale height,while lower-layer dryness increases it.Different humidity conditions in the upper and lower layers lead to variations in cloud type and volume distribution,ultimately affecting precipitation scale heights.This finding aids the mechanistic study of cloud precipitation physics in the tropics,providing valuable insights for developing numerical models and parameterizations.展开更多
Although numerous studies have proposed explanations for the specific and relative effects of stand structure,plant diversity,and environmental conditions on carbon(C)storage in forest ecosystems,understanding how the...Although numerous studies have proposed explanations for the specific and relative effects of stand structure,plant diversity,and environmental conditions on carbon(C)storage in forest ecosystems,understanding how these factors collectively affect C storage in different community layers(trees,shrubs,and herbs)and forest types(mixed,broad-leaved(E),broad-leaved(M),and coniferous forest)continues to pose challenges.To address this,we used structural equation models to quantify the influence of biotic factors(mean DBH,mean height,maximum height,stem density,and basal area)and abiotic factors(elevation and canopy openness),as well as metrics of species diversity(Shannon–Wiener index,Simpson index,and Pielou’s evenness)in various forest types.Our analysis revealed the critical roles of forest types and elevation in explaining a substantial portion of variability in C storage in the overstory layer,with a moderate influence of stand factors(mean DBH and basal area)and a slightly negative impact of tree species diversity(Shannon–Wiener index).Notably,forest height emerged as the primary predictor of C storage in the herb layer.Regression relationships further highlighted the significant contribution of tree species diversity to mean height,understory C storage,and branch biomass within the forest ecosystem.Our insights into tree species diversity,derived from structural equation modeling of C storage in the overstory,suggest that the effects of tree species diversity may be influenced by stem biomass in statistical reasoning within temperate forests.Further research should also integrate tree species diversity with tree components biomass,forest mean height,understory C,and canopy openness to understand complex relationships and maintain healthy and sustainable ecosystems in the face of global climate challenges.展开更多
Globally,hyperuricemia is a growing health,social,and economic problem which could cause gout,chronic kidney diseases and other diseases.There are increasing evidences that a sensible diet makes sense to reduce the ri...Globally,hyperuricemia is a growing health,social,and economic problem which could cause gout,chronic kidney diseases and other diseases.There are increasing evidences that a sensible diet makes sense to reduce the risk of hyperuricemia.This review aims to explore the metabolic mechanism of dietary factors and effects of dietary types associated with hyperuricemia.Recommendations for dietary modification to prevent hyperuricemia are as following:decreasing intake of animal organs,seafood,sugar-sweetened,and alcohol beverages is essential;choosing water or unsweetened tea and coffee instead of sweetened beverages is beneficial;and increasing intake of vegetables,reduced-fat dairy products,foods containing fiber,micronutrients and unsaturated fatty acids is helpful.In addition,consumption of fruits and legumes in moderation is advantageous,and low-fructose of fruits and low-purine of non-soy beans are recommended.Moreover,personalized diet needs to be emphasized for hyperuricemic patients accompanied with diverse metabolic diseases.展开更多
Background The diverse types and processing methods of grains intricately influence the sites and digestibility of starch digestion,thereby impacting energy utilization.This study aimed to explore the impact of grain ...Background The diverse types and processing methods of grains intricately influence the sites and digestibility of starch digestion,thereby impacting energy utilization.This study aimed to explore the impact of grain variety and processing methods on the net energy(NE)in dairy goats,analyzing these effects at the level of nutrient digestion and metabolism.Methods Eighteen castrated Guanzhong dairy goats(44.25±3.59 kg BW)were randomly divided into 3 groups,each consisting of 6 replicates.The substitution method was employed to determine the NE values of the dry-rolled corn(DRC),dry-rolled wheat(DRW)or steam-flaked corn(SFC,360 g/L).Briefly,two phases were performed.Throughout the basal phase,all goats were fed the same basal diet.In the substitution phase,30%of the basal diet was replaced with DRC,DRW and SFC,respectively.Results In this study,the NE values of the DRC,DRW and SFC were 7.65,7.54 and 7.44 MJ/kg DM,respectively.Compared to the DRC group,the DRW group showed increased digestibility of starch and crude protein(CP).Similarly,the SFC group exhibited increased organic matter(OM)and starch digestibility and a trend towards higher dry matter(DM)digestibility,reduced fecal OM and starch content.Additionally,fecal volatile fatty acid(VFA)concentrations decreased in goats fed SFC.Correspondingly,digestible energy(DE)in the DRW and SFC groups tended to be higher than in the DRC group.DRW increased total VFA concentration compared to DRC,while SFC increased the proportion of propionate and decreased the acetate-to-propionate ratio in the rumen.Both the DRW and SFC diets elevated serum glucose levels.Furthermore,heat increment(HI)and gaseous energy(Gas E)related to fermentation were significantly higher in the DRW and SFC groups compared to the DRC group.Conclusion Our findings indicated that DRW and SFC increased rumen starch fermentation in goats,thereby improving total tract starch digestion and DE.However,DRW and SFC failed to improve NE value due to increased heat and gas energy production from fermentation.Therefore,excessively refined grains processing in the diet of dairy goats does not effectively improve energy efficiency.展开更多
The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting...The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting one of the highest mortality rates associated with cancer globally.The delayed onset of symptoms and diagnosis often results in metastasis or local progression of the cancer,thereby constraining treatment options and outcomes.For these patients,prompt tumour identification and treatment strategising are crucial.The present objective of pancreatic cancer research is to examine the correlation between various pathological types and imaging data to facilitate therapeutic decision-making.This study aims to clarify the correlation between diverse pathological markers and imaging in pancreatic cancer patients,with prospective longitudinal studies potentially providing novel insights into the diagnosis and treatment of pancreatic cancer.展开更多
Various types of vegetative cover,predominantly woodlands,shrublands,and grasslands,provide a range of habitats for urban organisms and are the main contributors to urban ecosystem services.The goal of this study was ...Various types of vegetative cover,predominantly woodlands,shrublands,and grasslands,provide a range of habitats for urban organisms and are the main contributors to urban ecosystem services.The goal of this study was to assess the potential of different vegetation types in maintaining and enhancing bryophyte diversity in urban areas.Bryophytes,small non-vascular plants,in woodlands,shrublands,and grasslands in Hefei city(eastern China)were investigated,and their species richness,abundance,community composition and relationships with habitat characteristics were analysed.The results show that urban woodlands had the highest species richness and abundance of bryophytes and a distinct community composition compared with the other vegetation types.Relative light intensity had a positive effect on species richness in urban woodlands,whereas litter cover had a negative effect on abundance.Shrub,grass and litter covers,and relative air humidity were the main factors driving the differences in bryophyte species composition between woodlands and other vegetation types.Therefore,owing to their high potential to maintain bryophyte diversity,woodlands should receive increased attention during the construction of urban green spaces.In addition,promoting structural heterogeneity and increasing light availability would be beneficial to bryophyte species diversity.展开更多
Introduction In all branches of healthcare,clinicians are seen to be making professional judgements based on objective facts and assessments.However,in our daily lives,we recognise and celebrate individual differences...Introduction In all branches of healthcare,clinicians are seen to be making professional judgements based on objective facts and assessments.However,in our daily lives,we recognise and celebrate individual differences in interests,beliefs and personalities.展开更多
Precipitation types primarily include rainfall,snowfall,and sleet,and the transformation of precipitation types has significant impacts on regional climate,ecosystems,and the land-atmosphere system.This study employs ...Precipitation types primarily include rainfall,snowfall,and sleet,and the transformation of precipitation types has significant impacts on regional climate,ecosystems,and the land-atmosphere system.This study employs the Ding method to separate precipitation types from three datasets(CMFD,ERA5_Land,and CN05.1).Using data from 26meteorological observation stations in the Chinese Tianshan Mountains Region(CTMR)of China as the validation dataset,the precipitation type separation accuracy of three datasets was evaluated.Additionally,the impacts of relative humidity,precipitation amount,and air temperature on the accuracy of precipitation type separation were analyzed.The results indicate that the CMFD dataset provides the highest separation accuracy,followed by CN05.1,with ERA5_Land showing the poorest performance.Spatial correlation analysis reveals that CMFD outperforms the other two datasets at both annual and monthly scales.Root Mean Square Error(RMSE)and Mean Deviation(MD)values suggest that CMFD is more consistent with the station observational data.The analysis further demonstrates that relative humidity and precipitation amount significantly affect separation accuracy.After bias correction,the correlation coefficients between CMFD,ERA5_Land,and station observational data improved to 0.85-0.94,while the RMSE was controlled within 2 mm.The study also revealed that the overestimation of precipitation was positively correlated with the overestimation of rainfall days,negatively correlated with the overestimation of snowfall days,and that underestimated air temperatures led to an increase in the misclassification of snowfall days.This research provides a basis for selecting climate change datasets and managing water resources in alpine regions.展开更多
Collagen is a class of mammalian extracellular matrix of the main structural proteins,widely present in the skin,bone,muscle and other tissues and it plays a role in supporting,repairing,and protecting tissue cells.Na...Collagen is a class of mammalian extracellular matrix of the main structural proteins,widely present in the skin,bone,muscle and other tissues and it plays a role in supporting,repairing,and protecting tissue cells.Natural source extraction and artificial synthesis provide a rich source of collagen.As a macromolecular material,collagen has good application potential in cosmetics,pharmaceutical,medical and food industries.Collagen has generated a great deal of interest in the cosmetic industry due to its abundance,strength,and direct correlation with skin aging.Collagen is widely used in cosmetics due to its unique structure,good biocompatibility and low antigenicity,as well as rich biological functions.To enhance the youthfulness and health of the user,the cosmetic industry adds collagen to products such as eye creams,face creams,and nutritional supplements,and uses it in medical aesthetic techniques such as tissue fillers,skin replacement,and soft skin enhancement.This paper mainly reviews the sources and types of collagen used in cosmetics industry,then introduces the effects of collagen in cosmetics and prospects the development prospects of collagen in dermatologic and cosmetic fields.展开更多
To the Editor:As a student actively involved in advocacy for heart disease prevention,I was particularly intrigued by the policymaking implications of digital interventions in the article "Digital components and ...To the Editor:As a student actively involved in advocacy for heart disease prevention,I was particularly intrigued by the policymaking implications of digital interventions in the article "Digital components and interaction types in counseling interventions for childhood and adolescent obesity:A systematic review" [1].Through my work as the Founder and President of the nonprofit Guardians of Heart,I have developed and promoted early educational programs,digital tools,and community outreach initiatives designed to instill heart-healthy habits in youth,intending to mitigate risk factors such as obesity that significantly contribute to cardiovascular disease later in life.展开更多
Dynamic stress adjustment in deep-buried high geostress hard rock tunnels frequently triggers catastrophic failures such as rockbursts and collapses.While a comprehensive understanding of this process is critical for ...Dynamic stress adjustment in deep-buried high geostress hard rock tunnels frequently triggers catastrophic failures such as rockbursts and collapses.While a comprehensive understanding of this process is critical for evaluating surrounding rock stability,its dynamic evolution are often overlooked in engineering practice.This study systematically summarizes a novel classification framework for stress adjustment types—stabilizing(two-zoned),shallow failure(three-zoned),and deep failure(four-zoned)—characterized by distinct stress adjustment stages.A dynamic interpretation technology system is developed based on microseismic monitoring,integrating key microseismic parameters(energy index EI,apparent stressσa,microseismic activity S),seismic source parameter space clustering,and microseismic paths.This approach enables precise identification of evolutionary stages,stress adjustment types,and failure precursors,thereby elucidating the intrinsic linkage between geomechanical processes(stress redistribution)and failure risks.The study establishes criteria and procedures for identifying stress adjustment types and their associated failure risks,which were successfully applied in the Grand Canyon Tunnel of the E-han Highway to detect 50 instances of disaster risks.The findings offer invaluable insights into understanding the evolution process of stress adjustment and pinpointing the disaster risks linked to hard rock in comparable high geostress tunnels.展开更多
Fire season affects the dynamic changes of post-fire vegetation communities and carbon emissions.Analyzing its global patterns supports understanding of the ecological impacts of fires and responses of fires to climat...Fire season affects the dynamic changes of post-fire vegetation communities and carbon emissions.Analyzing its global patterns supports understanding of the ecological impacts of fires and responses of fires to climate change.Meteorological variables have been widely used to quantify fire season in current studies.However,their results can not be used to assess climate impacts on the seasonality of fire activities.Here we utilized satellite-based Moderate Resolution Imaging Spectroradiometer(MODIS)burned area data from 2001 to 2022 to identify global fire season types based on the number of peaks within a year.Using satellite data and innovatively processing the data to obtain a more accurate length of the fire season.We divided fire season types and examined the spatial distribution of fire season types across the Koppen-Geiger climate(KGC)zones.At a global scale,we identified three major fire season types,including unimodal(31.25%),bimodal(52.07%),and random(16.69%).The unimodal fire season primarily occurs in boreal and tropical regions lasting about 2.7 mon.In comparison,temperate ecosystems tend to have a longer fire season(3 mon)with two peaks throughout the year.The KGC zones show divergent contributions from the fire season types,indicating potential impacts of the climatic conditions on fire seasonality in these regions.展开更多
Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patien...Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patients.Methods:Anti-snake venom immunoglobulin(IgG)was prepared,biotinylated specific IgG was screened,detection enzyme-labeled strips were produced,and rapid identification of snakebites was performed.Pre-experimental verification was conducted to establish standard curves and confirm specificity.The kit was tested on clinical samples and the results were analyzed.Repeatability and stability were evaluated through multiple repeated tests and experiments under different storage conditions.Finally,sensitivity and specificity were calculated,receiver operating characteristic curves(ROC curves)were drawn,and statistical analysis software was used for data analysis to ensure the reliability and effectiveness of the kit.Results:The test showed high sensitivity and specificity.Conclusion:The rapid diagnostic kit for identifying snake venom types in blood tests demonstrates high reliability and effectiveness in clinical diagnosis.展开更多
To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation cells.There were 2701 particip...To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation cells.There were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with NGT.Plasma isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass spectrometry.Generalized linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and T2DM.Inflammatory cell was used as mediators to estimate the mediating effects on the above associations.Isocarbophos and isofenphos were positively related with T2DM after adjusting for other factors.The odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in ln-isocarbophos.The prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,respectively.Furthermore,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,respectively.Isofenphos and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.展开更多
BACKGROUND Appendicitis is an abdominal medical emergency and can be of various types.It can lead to a series of gastrointestinal symptoms and can affect health status.Therefore,attention should be paid to the diagnos...BACKGROUND Appendicitis is an abdominal medical emergency and can be of various types.It can lead to a series of gastrointestinal symptoms and can affect health status.Therefore,attention should be paid to the diagnosis of appendicitis to improve prognosis.AIM To assess the value of transabdominal superficial ultrasonography(TASU)in the clinical diagnosis of various types of appendicitis.METHODS A total of 100 patients suspected to have acute appendicitis that were admitted to our hospital between July 2022 and July 2024 were selected for this study.All of them underwent conventional abdominal ultrasonography and TASU.Taking surgical pathology as the gold standard,the diagnostic efficacy of the two ultrasonographic examinations was compared,and the ultrasonographic features of patients with different types of appendicitis were analyzed.RESULTS Comparison with the gold standard showed that among the 100 patients suspected of appendicitis,72 cases were diagnosed as appendicitis while 28 cases were deemed to be normal.Compared with conventional abdominal ultrasonography,TASU displayed a higher diagnostic efficiency(P<0.05).Among the 72 patients with acute appendicitis,22 cases were diagnosed as simple appendicitis,26 cases as suppurative appendicitis,and 24 cases as gangrenous appendicitis.TASU was more effective in the diagnosis of the various types of appendicitis,and the difference was significant between groups(P<0.05).Ultrasonography radiographs revealed an enlarged appendix with a tubular anechoic area,a widened lumen,with a visible occlusion or stercoral shadow and a cystic mass in the parenchyma.CONCLUSION TASU can accurately diagnose appendicitis and also be used to identify the various types of appendicitis,thereby having application value.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM),one of the most common chronic metabolic diseases,is also one of the most significant risk factors for cardiovascular disease(CVD)and chronic kidney disease(CKD).AIM To conduc...BACKGROUND Type 2 diabetes mellitus(T2DM),one of the most common chronic metabolic diseases,is also one of the most significant risk factors for cardiovascular disease(CVD)and chronic kidney disease(CKD).AIM To conduct a systematic review and network meta-analysis of cardiovascular(CV)and renal benefits of glucagon-like peptide-1 receptor agonists(GLP-1RA),sodium-glucose cotransporter-2 inhibitors(SGLT2i),and nonsteroidal mineralocorticoid receptor antagonists(nsMRA)in T2DM patients.METHODS We searched four databases-PubMed,EMBASE,Cochrane Library,and Web of Science-for publications from inception to March 6,2025.Total 500 participants were enrolled and had an intervention period of at least one year(or 52 weeks).Eligible studies included adult patients with T2DM and interventions with a placebo or another GLP-1RA,SGLT2i,or nsMRA.Data were standardized using Stata 17.0 software.The quality of evidence was assessed using the CINeMA and GRADE approaches.RESULTS Total 14970 articles were retrieved,of which 25 high-quality studies were included for the systematic review and network meta-analysis,covering 189797 patients and three drug classes(14 drugs).Network meta-analysis revealed low heterogeneity,thus ensuring reliable results.Meta-regression analysis indicated that baseline factors,such as comorbidities and blood glucose levels,did not affect our results.Overall,all included drugs demonstrated significant CV and renal benefits compared with the placebo.nsMRA showed the best efficacy in reducing the incidence of major adverse CV events and myocardial infarction.SGLT2i were most effective in reducing all-cause mortality,CV mortality,and the incidence of renal outcomes.GLP-1RA showed the greatest benefits in reducing the incidence of stroke.SC-semaglutide had the most significant effect on reducing major adverse CV events,oral semaglutide was most effective in reducing all-cause mortality and CV mortality,empagliflozin had the strongest effect in reducing composite renal outcomes and renal replacement therapy,canagliflozin was most effective in slowing the progression of proteinuria,and dapagliflozin showed the most significant reduction in end-stage renal disease.CONCLUSION T2DM,as one of the most common chronic metabolic diseases,is also one of the most significant risk factors for CVD and CKD.GLP-1RA,SGLT2i,and nsMRAs have emerged as novel therapeutic agents to comprehensively manage T2DM-related CVD and CKD.We conducted a network meta-analysis to compare the efficacy and safety of GLP-1RAs,SGLT2i,and nsMRA in patients with T2DM.展开更多
Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,t...Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and quantified.Molecular dynamics(MD)simulations are employed to observe the failure evolution of different microscopic defects.The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion.At the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain points.The impact of defect types on the failure process is also discussed.Furthermore,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale model.The validity of the crack propagation model is confirmed through tensile tests.Finally,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD model.Our findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.展开更多
基金supported by the Capital’s Funds for Health Improvement and Research(No.2024-2G-2118)the National Key Research and Development Program of China(2016YFC1000101)+2 种基金the Leading Talents in the Construction Project of High-Level Public Health Technical Talents in Beijing(2022-1-003)the“Green Seedling”Youth Program by the Beijing Hospitals Authority(QML20231402)the Young Elite Scientist Sponsorship Program by the Beijing Association for Science and Technology(BYESS2022200)。
文摘Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method.GDM diagnosis was based on a 75-g,2-h oral glucose tolerance test(OGTT)according to the criteria of the International Association of Diabetes and Pregnancy Study Groups.Logistic regression was applied to calculate the odds ratios(ORs)and 95%confidence intervals(CIs)between ABO blood types and GDM risk.Results A total of 30,740 pregnant women with a mean age of 31.81 years were enrolled in this study.The ABO blood types distribution was:type O(30.99%),type A(26.58%),type B(32.20%),and type AB(10.23%).GDM was identified in 14.44%of participants.Using blood type O as a reference,GDM risk was not significantly higher for types A(OR=1.05)or B(OR=1.04).However,women with type AB had a 19%increased risk of GDM(OR=1.19,95%CI=1.05–1.34;P<0.05),even after adjusting for various factors.This increased risk for type AB was consistent across subgroup and sensitivity analyses.Conclusion The ABO blood types may influence GDM risk,with type AB associated with a higher risk.Incorporating it—either as a single risk factor or in combination with other known factors—could help identify individuals at risk for GDM before or during early pregnancy.
文摘BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.
基金funded by grants from the National Key R&D Project(2023YFD1400201-02,2023YFD1400203-02)the National Natural Science Foundation of China(31870137)+1 种基金the National Transgenic Research Project(2015ZX08001-002)the Key R&D Project of Guangdong Province(2022B0202060005).
文摘Asian rice comprises two major subspecies:Xian(X)and Geng(G),and the diverged resistance genes(R)have provided a foundation for breeding improved cultivars to control rice blast disease.After conducting two-phase allele mining using six updated FNP marker systems,the functional haplotypes at Pit,Pib,and Pi63 strictly diverged into the X-populations and were defined as X-R loci,while those at Pi54,Pi37,and Pi36 into the G-populations as G-R loci.The genic diversity at the three X-R loci(16 alleles)was twofold higher than that at the three G-R loci(8 alleles),and the allelic diversity in the Southern region(21 alleles)was nearly double that in the Northeastern region(11 alleles).Both observations reflect a significant difference in genetic diversity between X-and G-populations,and indicate that the effective R-genes mainly originated from X-subspecies.Based on the allelic structures characterized by a set of 10 parameters,8 and 16 alleles were respectively recognized as favorable and promising ones for the regional breeding programs.The genotypic structures of the two regional populations were almost different,indicating that the diverged alleles have been further assembled into two series of regional genotypes through long-term breeding programs,despite the presence of one-third of region-common alleles.The genotypic diversity in the Southern region(55 genotypes)was nearly twice as high as that in the Northeastern region(28),which perfectly reflects the aforementioned differences in both genic and allelic diversities.After analyzing the genotypic structures using a set of 13 parameters,4 and 23 genotypes,respectively,can be recommended as the favorable and promising ones for the regional breeding programs.The case study serves as a concrete sample of how to identify the favorable and promising alleles and genotypes,and beneficial parents based their comprehensive population structures for gene-designed breeding.
基金supported by the National Natural Science Foundation of China[grant numbers 42175099 and 42027804]The appointment of Chunsong Lu at Nanjing University of Information Science&Technology was partially supported by the Jiangsu Specially-Appointed Professor[grant number R2024T01].
文摘Cloud type profoundly affects precipitation,but few studies have explored its impact on precipitation scale height.The authors calculated the ratio of the volume of each cloud type to the total cloud volume and partitioned the tropical region based on the dominant cloud types.Based on this,tropical regions were categorized into altocumulus control regions,stratocumulus control regions,deep convective cloud control regions,and transition regions.These regions exhibit unique characteristics:high precipitation scale heights and low surface precipitation rates in altocumulus control regions;low precipitation scale heights and low surface precipitation rates in stratocumulus control regions;and moderate precipitation scale heights with high surface precipitation rates in deep convective cloud regions.These features arise from differences in cloud characteristics,precipitation probability,and intensity,influenced by varying water vapor structures.In terms of physical mechanisms,altocumulus,stratocumulus,and deep convective cloud regions are characterized by total dryness,upper-level dryness with lower-level wetness,and total wetness,respectively.Upper-layer dryness leads to low cloud and precipitation structures,reducing the precipitation scale height,while lower-layer dryness increases it.Different humidity conditions in the upper and lower layers lead to variations in cloud type and volume distribution,ultimately affecting precipitation scale heights.This finding aids the mechanistic study of cloud precipitation physics in the tropics,providing valuable insights for developing numerical models and parameterizations.
基金supported by the Fundamental Research Funds for the Central Universities(2021ZY89)the National Natural Science Foundation of China(32201258 and 32271652)+4 种基金Research Service Project on the Effects of Extreme Climate on Biodiversity and Conservation Strategies in Mentougou District(2024HXFWBH-XJL-02)the Fang Jingyun Ecological Study Studio of Yunnan Province(China)the State Scholarship Fund of China(2011811457)support to the Xingdian Scholar Fund of Yunnan Provincethe Double Top University Fund of Yunnan University.
文摘Although numerous studies have proposed explanations for the specific and relative effects of stand structure,plant diversity,and environmental conditions on carbon(C)storage in forest ecosystems,understanding how these factors collectively affect C storage in different community layers(trees,shrubs,and herbs)and forest types(mixed,broad-leaved(E),broad-leaved(M),and coniferous forest)continues to pose challenges.To address this,we used structural equation models to quantify the influence of biotic factors(mean DBH,mean height,maximum height,stem density,and basal area)and abiotic factors(elevation and canopy openness),as well as metrics of species diversity(Shannon–Wiener index,Simpson index,and Pielou’s evenness)in various forest types.Our analysis revealed the critical roles of forest types and elevation in explaining a substantial portion of variability in C storage in the overstory layer,with a moderate influence of stand factors(mean DBH and basal area)and a slightly negative impact of tree species diversity(Shannon–Wiener index).Notably,forest height emerged as the primary predictor of C storage in the herb layer.Regression relationships further highlighted the significant contribution of tree species diversity to mean height,understory C storage,and branch biomass within the forest ecosystem.Our insights into tree species diversity,derived from structural equation modeling of C storage in the overstory,suggest that the effects of tree species diversity may be influenced by stem biomass in statistical reasoning within temperate forests.Further research should also integrate tree species diversity with tree components biomass,forest mean height,understory C,and canopy openness to understand complex relationships and maintain healthy and sustainable ecosystems in the face of global climate challenges.
基金supported by the National Natural Science Foundation of China(No.32122069)Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910011025)China Postdoctoral Science Foundation(No.2023M730134)。
文摘Globally,hyperuricemia is a growing health,social,and economic problem which could cause gout,chronic kidney diseases and other diseases.There are increasing evidences that a sensible diet makes sense to reduce the risk of hyperuricemia.This review aims to explore the metabolic mechanism of dietary factors and effects of dietary types associated with hyperuricemia.Recommendations for dietary modification to prevent hyperuricemia are as following:decreasing intake of animal organs,seafood,sugar-sweetened,and alcohol beverages is essential;choosing water or unsweetened tea and coffee instead of sweetened beverages is beneficial;and increasing intake of vegetables,reduced-fat dairy products,foods containing fiber,micronutrients and unsaturated fatty acids is helpful.In addition,consumption of fruits and legumes in moderation is advantageous,and low-fructose of fruits and low-purine of non-soy beans are recommended.Moreover,personalized diet needs to be emphasized for hyperuricemic patients accompanied with diverse metabolic diseases.
基金supported by the National Key Research and Development Program of China(2023YFE0111800)Shaanxi Livestock and Poultry Breeding Double-chain Fusion Key Project(grant number 2022GD-TSLD-46-0501)。
文摘Background The diverse types and processing methods of grains intricately influence the sites and digestibility of starch digestion,thereby impacting energy utilization.This study aimed to explore the impact of grain variety and processing methods on the net energy(NE)in dairy goats,analyzing these effects at the level of nutrient digestion and metabolism.Methods Eighteen castrated Guanzhong dairy goats(44.25±3.59 kg BW)were randomly divided into 3 groups,each consisting of 6 replicates.The substitution method was employed to determine the NE values of the dry-rolled corn(DRC),dry-rolled wheat(DRW)or steam-flaked corn(SFC,360 g/L).Briefly,two phases were performed.Throughout the basal phase,all goats were fed the same basal diet.In the substitution phase,30%of the basal diet was replaced with DRC,DRW and SFC,respectively.Results In this study,the NE values of the DRC,DRW and SFC were 7.65,7.54 and 7.44 MJ/kg DM,respectively.Compared to the DRC group,the DRW group showed increased digestibility of starch and crude protein(CP).Similarly,the SFC group exhibited increased organic matter(OM)and starch digestibility and a trend towards higher dry matter(DM)digestibility,reduced fecal OM and starch content.Additionally,fecal volatile fatty acid(VFA)concentrations decreased in goats fed SFC.Correspondingly,digestible energy(DE)in the DRW and SFC groups tended to be higher than in the DRC group.DRW increased total VFA concentration compared to DRC,while SFC increased the proportion of propionate and decreased the acetate-to-propionate ratio in the rumen.Both the DRW and SFC diets elevated serum glucose levels.Furthermore,heat increment(HI)and gaseous energy(Gas E)related to fermentation were significantly higher in the DRW and SFC groups compared to the DRC group.Conclusion Our findings indicated that DRW and SFC increased rumen starch fermentation in goats,thereby improving total tract starch digestion and DE.However,DRW and SFC failed to improve NE value due to increased heat and gas energy production from fermentation.Therefore,excessively refined grains processing in the diet of dairy goats does not effectively improve energy efficiency.
基金Supported by the National Health Commission’s Key Laboratory of Gastrointestinal Tumor Diagnosis and Treatment for The Year 2022,National Health Commission’s Master’s and Doctoral/Postdoctoral Fund Project,No.NHCDP2022001Gansu Provincial People’s Hospital Doctoral Supervisor Training Project,No.22GSSYA-3.
文摘The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting one of the highest mortality rates associated with cancer globally.The delayed onset of symptoms and diagnosis often results in metastasis or local progression of the cancer,thereby constraining treatment options and outcomes.For these patients,prompt tumour identification and treatment strategising are crucial.The present objective of pancreatic cancer research is to examine the correlation between various pathological types and imaging data to facilitate therapeutic decision-making.This study aims to clarify the correlation between diverse pathological markers and imaging in pancreatic cancer patients,with prospective longitudinal studies potentially providing novel insights into the diagnosis and treatment of pancreatic cancer.
基金funded by the Scientific Research Project of Anhui Higher Education Institutions(2022AH050915)the Anhui Agricultural University Natural Science Foundation Youth Project(K2137004)the Anhui Agricultural University Introducing and Stabilizing Talent Project(rc372103).
文摘Various types of vegetative cover,predominantly woodlands,shrublands,and grasslands,provide a range of habitats for urban organisms and are the main contributors to urban ecosystem services.The goal of this study was to assess the potential of different vegetation types in maintaining and enhancing bryophyte diversity in urban areas.Bryophytes,small non-vascular plants,in woodlands,shrublands,and grasslands in Hefei city(eastern China)were investigated,and their species richness,abundance,community composition and relationships with habitat characteristics were analysed.The results show that urban woodlands had the highest species richness and abundance of bryophytes and a distinct community composition compared with the other vegetation types.Relative light intensity had a positive effect on species richness in urban woodlands,whereas litter cover had a negative effect on abundance.Shrub,grass and litter covers,and relative air humidity were the main factors driving the differences in bryophyte species composition between woodlands and other vegetation types.Therefore,owing to their high potential to maintain bryophyte diversity,woodlands should receive increased attention during the construction of urban green spaces.In addition,promoting structural heterogeneity and increasing light availability would be beneficial to bryophyte species diversity.
文摘Introduction In all branches of healthcare,clinicians are seen to be making professional judgements based on objective facts and assessments.However,in our daily lives,we recognise and celebrate individual differences in interests,beliefs and personalities.
基金financial support from the National Natural Sciences Foundation of China(42261026,and 42161025)the Open Foundation of Xinjiang Key Laboratory of Water Cycle and Utilization in Arid Zone(XJYS0907-2023-01)。
文摘Precipitation types primarily include rainfall,snowfall,and sleet,and the transformation of precipitation types has significant impacts on regional climate,ecosystems,and the land-atmosphere system.This study employs the Ding method to separate precipitation types from three datasets(CMFD,ERA5_Land,and CN05.1).Using data from 26meteorological observation stations in the Chinese Tianshan Mountains Region(CTMR)of China as the validation dataset,the precipitation type separation accuracy of three datasets was evaluated.Additionally,the impacts of relative humidity,precipitation amount,and air temperature on the accuracy of precipitation type separation were analyzed.The results indicate that the CMFD dataset provides the highest separation accuracy,followed by CN05.1,with ERA5_Land showing the poorest performance.Spatial correlation analysis reveals that CMFD outperforms the other two datasets at both annual and monthly scales.Root Mean Square Error(RMSE)and Mean Deviation(MD)values suggest that CMFD is more consistent with the station observational data.The analysis further demonstrates that relative humidity and precipitation amount significantly affect separation accuracy.After bias correction,the correlation coefficients between CMFD,ERA5_Land,and station observational data improved to 0.85-0.94,while the RMSE was controlled within 2 mm.The study also revealed that the overestimation of precipitation was positively correlated with the overestimation of rainfall days,negatively correlated with the overestimation of snowfall days,and that underestimated air temperatures led to an increase in the misclassification of snowfall days.This research provides a basis for selecting climate change datasets and managing water resources in alpine regions.
文摘Collagen is a class of mammalian extracellular matrix of the main structural proteins,widely present in the skin,bone,muscle and other tissues and it plays a role in supporting,repairing,and protecting tissue cells.Natural source extraction and artificial synthesis provide a rich source of collagen.As a macromolecular material,collagen has good application potential in cosmetics,pharmaceutical,medical and food industries.Collagen has generated a great deal of interest in the cosmetic industry due to its abundance,strength,and direct correlation with skin aging.Collagen is widely used in cosmetics due to its unique structure,good biocompatibility and low antigenicity,as well as rich biological functions.To enhance the youthfulness and health of the user,the cosmetic industry adds collagen to products such as eye creams,face creams,and nutritional supplements,and uses it in medical aesthetic techniques such as tissue fillers,skin replacement,and soft skin enhancement.This paper mainly reviews the sources and types of collagen used in cosmetics industry,then introduces the effects of collagen in cosmetics and prospects the development prospects of collagen in dermatologic and cosmetic fields.
文摘To the Editor:As a student actively involved in advocacy for heart disease prevention,I was particularly intrigued by the policymaking implications of digital interventions in the article "Digital components and interaction types in counseling interventions for childhood and adolescent obesity:A systematic review" [1].Through my work as the Founder and President of the nonprofit Guardians of Heart,I have developed and promoted early educational programs,digital tools,and community outreach initiatives designed to instill heart-healthy habits in youth,intending to mitigate risk factors such as obesity that significantly contribute to cardiovascular disease later in life.
基金supported by the National Natural Science Foundation of China(Nos.42177173,U23A20651 and 42130719)and the Outstanding Youth Science Fund Project of Sichuan Provincial Natural Science Foundation(No.2025NSFJQ0003)。
文摘Dynamic stress adjustment in deep-buried high geostress hard rock tunnels frequently triggers catastrophic failures such as rockbursts and collapses.While a comprehensive understanding of this process is critical for evaluating surrounding rock stability,its dynamic evolution are often overlooked in engineering practice.This study systematically summarizes a novel classification framework for stress adjustment types—stabilizing(two-zoned),shallow failure(three-zoned),and deep failure(four-zoned)—characterized by distinct stress adjustment stages.A dynamic interpretation technology system is developed based on microseismic monitoring,integrating key microseismic parameters(energy index EI,apparent stressσa,microseismic activity S),seismic source parameter space clustering,and microseismic paths.This approach enables precise identification of evolutionary stages,stress adjustment types,and failure precursors,thereby elucidating the intrinsic linkage between geomechanical processes(stress redistribution)and failure risks.The study establishes criteria and procedures for identifying stress adjustment types and their associated failure risks,which were successfully applied in the Grand Canyon Tunnel of the E-han Highway to detect 50 instances of disaster risks.The findings offer invaluable insights into understanding the evolution process of stress adjustment and pinpointing the disaster risks linked to hard rock in comparable high geostress tunnels.
基金Under the auspices of the National Key Research and Development Program of China(No.2019YFA0606603)。
文摘Fire season affects the dynamic changes of post-fire vegetation communities and carbon emissions.Analyzing its global patterns supports understanding of the ecological impacts of fires and responses of fires to climate change.Meteorological variables have been widely used to quantify fire season in current studies.However,their results can not be used to assess climate impacts on the seasonality of fire activities.Here we utilized satellite-based Moderate Resolution Imaging Spectroradiometer(MODIS)burned area data from 2001 to 2022 to identify global fire season types based on the number of peaks within a year.Using satellite data and innovatively processing the data to obtain a more accurate length of the fire season.We divided fire season types and examined the spatial distribution of fire season types across the Koppen-Geiger climate(KGC)zones.At a global scale,we identified three major fire season types,including unimodal(31.25%),bimodal(52.07%),and random(16.69%).The unimodal fire season primarily occurs in boreal and tropical regions lasting about 2.7 mon.In comparison,temperate ecosystems tend to have a longer fire season(3 mon)with two peaks throughout the year.The KGC zones show divergent contributions from the fire season types,indicating potential impacts of the climatic conditions on fire seasonality in these regions.
基金Rapid Identification and Analysis of Snake Venom Types in Snakebites in Renshou County,(Project No.:2024KJZD072)。
文摘Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patients.Methods:Anti-snake venom immunoglobulin(IgG)was prepared,biotinylated specific IgG was screened,detection enzyme-labeled strips were produced,and rapid identification of snakebites was performed.Pre-experimental verification was conducted to establish standard curves and confirm specificity.The kit was tested on clinical samples and the results were analyzed.Repeatability and stability were evaluated through multiple repeated tests and experiments under different storage conditions.Finally,sensitivity and specificity were calculated,receiver operating characteristic curves(ROC curves)were drawn,and statistical analysis software was used for data analysis to ensure the reliability and effectiveness of the kit.Results:The test showed high sensitivity and specificity.Conclusion:The rapid diagnostic kit for identifying snake venom types in blood tests demonstrates high reliability and effectiveness in clinical diagnosis.
基金supported by the National Natural Science Foundation of China(Nos.42177415 and 21806146)the Scientific and Technological Innovation of Colleges and Universities in Henan Province Talent Support Program(No.22HASTIT044)the Young Backbone Teachers Programof Colleges and Universities in Henan Province(No.2021GGJS015).
文摘To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation cells.There were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with NGT.Plasma isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass spectrometry.Generalized linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and T2DM.Inflammatory cell was used as mediators to estimate the mediating effects on the above associations.Isocarbophos and isofenphos were positively related with T2DM after adjusting for other factors.The odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in ln-isocarbophos.The prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,respectively.Furthermore,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,respectively.Isofenphos and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.
文摘BACKGROUND Appendicitis is an abdominal medical emergency and can be of various types.It can lead to a series of gastrointestinal symptoms and can affect health status.Therefore,attention should be paid to the diagnosis of appendicitis to improve prognosis.AIM To assess the value of transabdominal superficial ultrasonography(TASU)in the clinical diagnosis of various types of appendicitis.METHODS A total of 100 patients suspected to have acute appendicitis that were admitted to our hospital between July 2022 and July 2024 were selected for this study.All of them underwent conventional abdominal ultrasonography and TASU.Taking surgical pathology as the gold standard,the diagnostic efficacy of the two ultrasonographic examinations was compared,and the ultrasonographic features of patients with different types of appendicitis were analyzed.RESULTS Comparison with the gold standard showed that among the 100 patients suspected of appendicitis,72 cases were diagnosed as appendicitis while 28 cases were deemed to be normal.Compared with conventional abdominal ultrasonography,TASU displayed a higher diagnostic efficiency(P<0.05).Among the 72 patients with acute appendicitis,22 cases were diagnosed as simple appendicitis,26 cases as suppurative appendicitis,and 24 cases as gangrenous appendicitis.TASU was more effective in the diagnosis of the various types of appendicitis,and the difference was significant between groups(P<0.05).Ultrasonography radiographs revealed an enlarged appendix with a tubular anechoic area,a widened lumen,with a visible occlusion or stercoral shadow and a cystic mass in the parenchyma.CONCLUSION TASU can accurately diagnose appendicitis and also be used to identify the various types of appendicitis,thereby having application value.
基金Supported by National Natural Science Foundation of China,No.82305205Young Elite Scientists Sponsorship Program by CACM,No.CACM-2023-QNRC2-A05+1 种基金the Safeguard Project of Guang'anmen Hospital,China Academy of Chinese Medical Sciences,No.GAMHH9324001the Special Fund for Outstanding Young Scientific Talent Training of the Fundamental Research Business Expenses of the China Academy of Chinese Medical Sciences,No.ZZ18-YQ-011.
文摘BACKGROUND Type 2 diabetes mellitus(T2DM),one of the most common chronic metabolic diseases,is also one of the most significant risk factors for cardiovascular disease(CVD)and chronic kidney disease(CKD).AIM To conduct a systematic review and network meta-analysis of cardiovascular(CV)and renal benefits of glucagon-like peptide-1 receptor agonists(GLP-1RA),sodium-glucose cotransporter-2 inhibitors(SGLT2i),and nonsteroidal mineralocorticoid receptor antagonists(nsMRA)in T2DM patients.METHODS We searched four databases-PubMed,EMBASE,Cochrane Library,and Web of Science-for publications from inception to March 6,2025.Total 500 participants were enrolled and had an intervention period of at least one year(or 52 weeks).Eligible studies included adult patients with T2DM and interventions with a placebo or another GLP-1RA,SGLT2i,or nsMRA.Data were standardized using Stata 17.0 software.The quality of evidence was assessed using the CINeMA and GRADE approaches.RESULTS Total 14970 articles were retrieved,of which 25 high-quality studies were included for the systematic review and network meta-analysis,covering 189797 patients and three drug classes(14 drugs).Network meta-analysis revealed low heterogeneity,thus ensuring reliable results.Meta-regression analysis indicated that baseline factors,such as comorbidities and blood glucose levels,did not affect our results.Overall,all included drugs demonstrated significant CV and renal benefits compared with the placebo.nsMRA showed the best efficacy in reducing the incidence of major adverse CV events and myocardial infarction.SGLT2i were most effective in reducing all-cause mortality,CV mortality,and the incidence of renal outcomes.GLP-1RA showed the greatest benefits in reducing the incidence of stroke.SC-semaglutide had the most significant effect on reducing major adverse CV events,oral semaglutide was most effective in reducing all-cause mortality and CV mortality,empagliflozin had the strongest effect in reducing composite renal outcomes and renal replacement therapy,canagliflozin was most effective in slowing the progression of proteinuria,and dapagliflozin showed the most significant reduction in end-stage renal disease.CONCLUSION T2DM,as one of the most common chronic metabolic diseases,is also one of the most significant risk factors for CVD and CKD.GLP-1RA,SGLT2i,and nsMRAs have emerged as novel therapeutic agents to comprehensively manage T2DM-related CVD and CKD.We conducted a network meta-analysis to compare the efficacy and safety of GLP-1RAs,SGLT2i,and nsMRA in patients with T2DM.
基金supported by the China Scholarship Council (CSC) (No.202206020149)the Academic Excellence Foundation of BUAA for PhD Students,the Funding Project of Science and Technology on Reliability and Environmental Engineering Laboratory (No.6142004210106).
文摘Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and quantified.Molecular dynamics(MD)simulations are employed to observe the failure evolution of different microscopic defects.The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion.At the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain points.The impact of defect types on the failure process is also discussed.Furthermore,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale model.The validity of the crack propagation model is confirmed through tensile tests.Finally,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD model.Our findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.
