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Reanalysis of energy band structure in the type-II quantum wells
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作者 李欣欣 邓震 +4 位作者 江洋 杜春花 贾海强 王文新 陈弘 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期75-78,共4页
Band structure analysis holds significant importance for understanding the optoelectronic characteristics of semiconductor structures and exploring their potential applications in practice. For quantum well structures... Band structure analysis holds significant importance for understanding the optoelectronic characteristics of semiconductor structures and exploring their potential applications in practice. For quantum well structures, the energy of carriers in the well splits into discrete energy levels due to the confinement of barriers in the growth direction. However, the discrete energy levels obtained at a fixed wave vector cannot accurately reflect the actual energy band structure. In this work, the band structure of the type-II quantum wells is reanalyzed. When the wave vectors of the entire Brillouin region(corresponding to the growth direction) are taken into account, the quantized energy levels of the carriers in the well are replaced by subbands with certain energy distributions. This new understanding of the energy bands of low-dimensional structures not only helps us to have a deeper cognition of the structure, but also may overturn many viewpoints in traditional band theories and serve as supplementary to the band theory of low-dimensional systems. 展开更多
关键词 energy band structure type-ii quantum wells low-dimensional semiconductors
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Estimation of Generalized Pareto under an Adaptive Type-II Progressive Censoring 被引量:2
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作者 Mohamed A. W. Mahmoud Ahmed A. Soliman +1 位作者 Ahmed H. Abd Ellah Rashad M. El-Sagheer 《Intelligent Information Management》 2013年第3期73-83,共11页
In this paper, based on a new type of censoring scheme called an adaptive type-II progressive censoring scheme introduce by Ng et al. [1], Naval Research Logistics is considered. Based on this type of censoring the ma... In this paper, based on a new type of censoring scheme called an adaptive type-II progressive censoring scheme introduce by Ng et al. [1], Naval Research Logistics is considered. Based on this type of censoring the maximum likelihood estimation (MLE), Bayes estimation, and parametric bootstrap method are used for estimating the unknown parameters. Also, we propose to apply Markov chain Monte Carlo (MCMC) technique to carry out a Bayesian estimation procedure and in turn calculate the credible intervals. Point estimation and confidence intervals based on maximum likelihood and bootstrap method are also proposed. The approximate Bayes estimators obtained under the assumptions of non-informative priors, are compared with the maximum likelihood estimators. Numerical examples using real data set are presented to illustrate the methods of inference developed here. Finally, the maximum likelihood, bootstrap and the different Bayes estimates are compared via a Monte Carlo simulation study. 展开更多
关键词 Generalized PARETO (GP) Distribution An ADAPTIVE type-ii Progressive CENSORING Scheme BAYESIAN and Non-Bayesian Estimations Gibbs and Metropolis SAMPLER Bootstrap
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Multiple Type-II截尾样本的统计方法 被引量:2
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作者 费鹤良 《上海师范大学学报(自然科学版)》 2001年第3期6-13,共8页
Multiple Type-II截尾样本或称为带有缺失的定数截尾样本在实际中常会遇到 ,最近十多年来有关它的统计分析方法有了较多的研究结果 ,作者作了综述 。
关键词 缺失定数截尾样本 指数分布 威布尔分布 极大拟然估计 区间估计 MULTIPLE Type-Ⅱ截尾样本
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Growth Optimization, Strain Compensation and Structure Design of InAs/GaSb Type-II Superlattices for Mid-Infrared Imaging 被引量:2
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作者 Yuxin Song Shumin Wang +5 位作者 Carl Asplund Rickard Marcks von Würtemberg Hedda Malm Amir Karim Xiang Lu Jun Shao 《Crystal Structure Theory and Applications》 2013年第2期46-56,共11页
InAs/GaSb type-II superlattce (T2SL) photodetector structures at the MWIR regime were grown by molecular beam epitaxy. The growth temperature and group-V soaking times were optimized with respect to interface and tran... InAs/GaSb type-II superlattce (T2SL) photodetector structures at the MWIR regime were grown by molecular beam epitaxy. The growth temperature and group-V soaking times were optimized with respect to interface and transport quality. Novel strain compensation schemes with insertion of InSb layers were proposed and tested to be efficient to tune the overall strain between tensile and compressive without degradation of interface and optical quality. The effect of the proposed methods is modeled by analytic functions.? Band structure calculations were also carried out for the proposed T2SL structures to assist optimizing sample designs. Single pixel photodiodes with a low dark current were demonstrated. 展开更多
关键词 INAS/GASB type-ii Superlattce Molecular Beam EPITAXY Strain COMPENSATION
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A New Rayleigh Distribution:Properties and Estimation Based on Progressive Type-II Censored Data with an Application 被引量:1
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作者 Ali Algarni Abdullah M.Almarashi 《Computer Modeling in Engineering & Sciences》 SCIE EI 2022年第1期379-396,共18页
In this paper,we propose a new extension of the traditional Rayleigh distribution called the modified Kies Rayleigh distribution.The new distribution contains one scale and one shape parameter and its hazard rate func... In this paper,we propose a new extension of the traditional Rayleigh distribution called the modified Kies Rayleigh distribution.The new distribution contains one scale and one shape parameter and its hazard rate function can be increasing and bathtub-shaped.Some mathematical properties of the new distribution are derived including quantiles and moments.The parameters of modified Kies Rayleigh distribution are estimated based on progressively Type-II censored data.For this purpose,we consider two estimation methods,namely maximum likelihood and maximum product of spacing estimation methods.To compare the efficiency of the proposed estimators,a simulation study is carried out.To show the applicability of the new model as well as the estimation methods,one real data for failure times of software is analyzed.Based on the empirical parts,we can conclude that the proposed model can be considered as a good model in the field of life testing and reliability analysis compared with other competing models. 展开更多
关键词 Rayleigh distribution modified kies family progressive type-ii censored maximum likelihood estimation maximum product of spacing
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EFFECT OF MAGNETIC NANOPARTICLES ON THE MECHANICAL PROPERTIES OF TYPE-II SUPERCONDUCTORS
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作者 Chenguang Huang Huadong Yong Youhe Zhou 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2014年第1期65-72,共8页
In this paper, the effect of magnetic nanoparticles on the mechanical properties of a type-II superconductor is investigated both theoretically and numerically. Magnetic part of the pinning force associated with the i... In this paper, the effect of magnetic nanoparticles on the mechanical properties of a type-II superconductor is investigated both theoretically and numerically. Magnetic part of the pinning force associated with the interaction between a finite-size spheroidal magnetic inclusion and an Abrikosov vortex is calculated in the London approximation. It is found that the size and shape of magnetic nanoparticles result in different enhancements of vortex pinning in large-k type-II superconductors. Meanwhile, the screening current induced by a magnetic spheroid suffer the action of Lorentz force, which will lead to prestress in the superconductor, so further numerical calculations are needed to explore the interaction between the spheroidal magnetic particle and superconductor. The distribution of displacement, stress and strain in the superconductor are finally obtained. It is shown that different sizes and shapes of nanoparticles also can change the distributions of these quantities. 展开更多
关键词 magnetic nanoparticles spheroidal inclusion pinning force stress distribution type-ii superconductor
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Electronic band structure of a type-II 'W' quantum well calculated by an eight-band k·p model
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作者 迂修 谷永先 +2 位作者 王青 韦欣 陈良惠 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第3期95-100,共6页
In this paper, we present an investigation of type-II 'W' quantum wells for the InAs/Ga1-xInxSb/A1Sb family, where 'W' denotes the conduction profile of the material. We focus our attention on using the eight-band... In this paper, we present an investigation of type-II 'W' quantum wells for the InAs/Ga1-xInxSb/A1Sb family, where 'W' denotes the conduction profile of the material. We focus our attention on using the eight-band k. p model to calculate the band structures within the framework of finite element method. For the sake of clarity, the simulation in this paper is simplified and based on only one period--A1Sb/InAs/Ga1-xInxSb/InAs/A1Sb. The obtained numerical results include the energy levels and wavefunctions of carriers. We discuss the variations of the electronic properties by changing several important parameters, such as the thickness of either InAs or Cal_xInxSb layer and the alloy composition in Ga1-xInxSb separately. In the last part, in order to compare the eight-band k·p model, we recalculate the conduction bands of the 'W' structure using the one-band k·p model and then discuss the difference between the two results, showing that conduction bands are strongly coupled with valence bands in the narrow band gap structure. The in-plane energy dispersions, which illustrate the suppression of the Auger recombination process, are also obtained. 展开更多
关键词 type-ii 'W' quantum well Burt-Foreman Hamiltonian finite element methods
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Long-lived Single Excitons, Trions, and Biexcitons in CdSe/CdTe Type-II Colloidal Quantum Wells
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作者 王俊慧 梁桂杰 吴凯丰 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2017年第6期649-656,I0001,共9页
Light-harvesters with long-lived excited states are desired for efficient solar energy conversion systems. Many solar-to-fuel conversion reactions, such as H2 evolution and CO2 reduction, require multiple sequential e... Light-harvesters with long-lived excited states are desired for efficient solar energy conversion systems. Many solar-to-fuel conversion reactions, such as H2 evolution and CO2 reduction, require multiple sequential electron transfer processes, which leads to a complicated situation that excited states involves not only excitons (electron-hole pairs) but also multi-excitons and charged excitons. While long-lived excitons can be obtained in various systems (e.g., semiconductor nanocrystals), multi-excitons and charged excitons are typically shorted-lived due to nonradiative Auger recombination pathways whereby the recombination energy of an exciton is quickly transferred to the third carrier on a few to hundreds of picoseconds timescale. In this work, we report a study of excitons, trions (an exciton plus an additional charge), and biexcitons in CdSe/CdTe colloidal quantum wells or nanoplatelets. The type- II band alignment effectively separates electrons and holes in space, leading to a single exciton lifetime of 340 ns which is -2 order of magnitudes longer than that in plane CdSe nanoplatelets. More importantly, the electron-hole separation also dramatically slows down Auger decay, giving rise to a trion lifetime of 70 ns and a biexciton lifetime of 11 ns, among the longest values ever reported for colloidal nanocrystals. The long-lived exciton, trion, and biexciton states, combined with the intrinsically strong light-absorption capability of two-dimensional systems, enable the CdSe/CdTe type-II nanoplatelets as promising light harvesters for efficient solar-to-fuel conversion reactions. 展开更多
关键词 Solar energy Excited state lifetime Exciton TRION BIEXCITON type-ii quan-tum wells NANOPLATELETS Auger recombination
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Statistical Inference of Chen Distribution Based on Two Progressive Type-II Censoring Schemes
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作者 Hassan M.Aljohani 《Computers, Materials & Continua》 SCIE EI 2021年第3期2797-2814,共18页
An inverse problemin practical scientific investigations is the process of computing unknown parameters from a set of observations where the observations are only recorded indirectly,such as monitoring and controlling... An inverse problemin practical scientific investigations is the process of computing unknown parameters from a set of observations where the observations are only recorded indirectly,such as monitoring and controlling quality in industrial process control.Linear regression can be thought of as linear inverse problems.In other words,the procedure of unknown estimation parameters can be expressed as an inverse problem.However,maximum likelihood provides an unstable solution,and the problembecomes more complicated if unknown parameters are estimated from different samples.Hence,researchers search for better estimates.We study two joint censoring schemes for lifetime products in industrial process monitoring.In practice,this type of data can be collected in fields such as the medical industry and industrial engineering.In this study,statistical inference for the Chen lifetime products is considered and analyzed to estimate underlying parameters.Maximum likelihood and Bayes’rule are both studied for model parameters.The asymptotic distribution of maximumlikelihood estimators and the empirical distributions obtained withMarkov chainMonte Carlo algorithms are utilized to build the interval estimators.Theoretical results using tables and figures are adopted through simulation studies and verified in an analysis of the lifetime data.We briefly describe the performance of developed methods. 展开更多
关键词 Chen distributions progressive type-ii censoring maximum likelihood mean posterior Bayesian estimation MCMC
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Reliability Analysis of HEE Parameters via Progressive Type-II Censoring with Applications
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作者 Heba S.Mohammed Mazen Nassar +1 位作者 Refah Alotaibi Ahmed Elshahhat 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第12期2761-2793,共33页
A new extended exponential lifetime model called Harris extended-exponential(HEE)distribution for data modelling with increasing and decreasing hazard rate shapes has been considered.In the reliability context,researc... A new extended exponential lifetime model called Harris extended-exponential(HEE)distribution for data modelling with increasing and decreasing hazard rate shapes has been considered.In the reliability context,researchers prefer to use censoring plans to collect data in order to achieve a compromise between total test time and/or test sample size.So,this study considers both maximum likelihood and Bayesian estimates of the Harris extended-exponential distribution parameters and some of its reliability indices using a progressive Type-II censoring strategy.Under the premise of independent gamma priors,the Bayesian estimation is created using the squared-error and general entropy loss functions.Due to the challenging form of the joint posterior distribution,to evaluate the Bayes estimates,samples from the full conditional distributions are generated using Markov Chain Monte Carlo techniques.For each unknown parameter,the highest posterior density credible intervals and asymptotic confidence intervals are also determined.Through a simulated study,the usefulness of the various suggested strategies is assessed.The optimal progressive censoring plans are also shown,and various optimality criteria are investigated.Two actual data sets,taken from engineering and veterinary medicine areas,are analyzed to show how the offered point and interval estimators can be used in practice and to verify that the proposed model furnishes a good fit than other lifetimemodels:alpha power exponential,generalized-exponential,Nadarajah-Haghighi,Weibull,Lomax,gamma and exponential distributions.Numerical evaluations revealed that in the presence of progressively Type-II censored data,the Bayes estimation method against the squared-error(symmetric)loss is advised for getting the point and interval estimates of the HEE distribution. 展开更多
关键词 Harris extended-exponential model progressive type-ii censoring RELIABILITY maximum likelihood MCMC techniques Monte Carlo experiments
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Inference on Constant-Partially Accelerated Life Tests for Mixture of Pareto Distributions under Progressive Type-II Censoring
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作者 Tahani A. Abushal Areej M. AL-Zaydi 《Open Journal of Statistics》 2017年第2期323-346,共24页
The main purpose of this paper is to obtain the inference of parameters of heterogeneous population represented by finite mixture of two Pareto (MTP) distributions of the second kind. The constant-partially accelerate... The main purpose of this paper is to obtain the inference of parameters of heterogeneous population represented by finite mixture of two Pareto (MTP) distributions of the second kind. The constant-partially accelerated life tests are applied based on progressively type-II censored samples. The maximum likelihood estimates (MLEs) for the considered parameters are obtained by solving the likelihood equations of the model parameters numerically. The Bayes estimators are obtained by using Markov chain Monte Carlo algorithm under the balanced squared error loss function. Based on Monte Carlo simulation, Bayes estimators are compared with their corresponding maximum likelihood estimators. The two-sample prediction technique is considered to derive Bayesian prediction bounds for future order statistics based on progressively type-II censored informative samples obtained from constant-partially accelerated life testing models. The informative and future samples are assumed to be obtained from the same population. The coverage probabilities and the average interval lengths of the confidence intervals are computed via a Monte Carlo simulation to investigate the procedure of the prediction intervals. Analysis of a simulated data set has also been presented for illustrative purposes. Finally, comparisons are made between Bayesian and maximum likelihood estimators via a Monte Carlo simulation study. 展开更多
关键词 Pareto Distribution Finite Mixtures Constant—Partially ALT Progressive type-ii CENSORING BAYESIAN ESTIMATION Maximum LIKELIHOOD ESTIMATION BAYESIAN PREDICTION the Two-Sample PREDICTION MCMC
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AN INTERPOLATION METHOD BY BIVARIATE CUBIC SPLINES WITH C^2 -JOIN ON TYPE-II TRIANGULARS AT A RECTANGULAR DOMAIN
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作者 Tianxiang Zhou Peicai Xuan 《Analysis in Theory and Applications》 2009年第2期125-141,共17页
In this paper, an interpolating method for bivariate cubic splines with C2-join on type-II triangular at a rectangular domain is given, and the approximation degree, inter- polating existence and uniqueness of the cub... In this paper, an interpolating method for bivariate cubic splines with C2-join on type-II triangular at a rectangular domain is given, and the approximation degree, inter- polating existence and uniqueness of the cubic splines are studied. 展开更多
关键词 type-ii triangulation bivariate cubic spline
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Bianchi Type-II, VIII &IX Perfect Fluid Cosmological Models in Brans Dicke Theory of Gravitation
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作者 Velagapudi Uma Maheswara Rao Mandangi Vijaya Santhi 《Journal of Modern Physics》 2011年第10期1222-1228,共7页
Field equations in the presence of perfect fluid distribution are obtained in a scalar tensor theory of gravitation proposed by Brans and Dicke[1] with the aid of Bianchi type-II, VIII & IX metrics. Exact prefect ... Field equations in the presence of perfect fluid distribution are obtained in a scalar tensor theory of gravitation proposed by Brans and Dicke[1] with the aid of Bianchi type-II, VIII & IX metrics. Exact prefect fluid Bianchi type- IX cosmological model is presented since other models doesn’t exist in Brans-Dicke scalar tensor theory of gravitation. Some physical properties of the model are also discussed. 展开更多
关键词 Bianchi type-ii VIII & IX Brans Dicke SCALAR Tensor THEORY Perfect Fluid Distribution
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Long-Period InAs/GaSb Type-II Superlattices for Terahertz Application
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作者 Longlong Li Jun Ni Wen Xu 《Journal of Modern Physics》 2014年第17期1880-1888,共9页
We present a theoretical study on the terahertz (THz) optoelectronic properties of long-period InAs/GaSb type-II super lattices (SLs). The eight-band k·p model is used to calculate the electronic structures of su... We present a theoretical study on the terahertz (THz) optoelectronic properties of long-period InAs/GaSb type-II super lattices (SLs). The eight-band k·p model is used to calculate the electronic structures of such SLs and on the basis of band structures, the Boltzmann equation approach is employed to calculate the optical absorption coefficients for the corresponding SL systems. It is found that long-period InAs/GaSb type-II SLs have a considerable absorption in the THz bandwidth. By examining the dependence of THz absorption coefficient on the InAs/GaSb layer widths, we demonstrate that with a proper choice of InAs/GaSb layer widths, an optimized THz absorption can be achieved. This study is pertinent to the potential application of InAs/GaSb type-II SLs as THz photo detectors. 展开更多
关键词 Long-Period INAS/GASB type-ii SLS THZ OPTOELECTRONIC Properties THZ Band-Gap and Absorption
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ZnSeTe/CdZnSe-based type-II core-shell quantum dots with tunable blue emission
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作者 Muhammad Ramzan Chenhui Wang +4 位作者 Mingrui Liu Peng Huang Jing Li Yin Song Haizheng Zhong 《Nano Research》 2025年第9期39-45,共7页
Blue emissive quantum dots are key materials in emerging light-emitting technologies for display applications.Herein,we report the synthesis of ZnSeTe/CdZnSe-based type-II core–shell quantum dots with a low Cd conten... Blue emissive quantum dots are key materials in emerging light-emitting technologies for display applications.Herein,we report the synthesis of ZnSeTe/CdZnSe-based type-II core–shell quantum dots with a low Cd content of less than 2.5%.By modifying the Cd content of the CdZnSe shell,photoluminescence emission can be tuned from 430 to 510 nm with a full width at half maximum of less than 26 nm.Transient absorption spectra illustrate the charge transfer between the conduction band of ZnSeTe and the conduction band of CdZnSe,as well as the recombination between the valence band of ZnSeTe and the conduction band of CdZnSe.By subsequent growth of ZnSe and ZnS shells,the resulting quantum dots achieved a photoluminescence quantum yield of 95%.We further demonstrate a blue quantum dot light-emitting diode with an emission peak at 467 nm,showing a maximum external quantum efficiency of 5%,a maximum luminance of 10,376 cd·m^(-2),and an extrapolated T95 lifetime of 4.7 h. 展开更多
关键词 quantum dot blue emission type-ii light-emitting diode DISPLAY
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Edge solitons in non-Hermitian photonic lattices with type-II Dirac cones
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作者 Shuang Shen Milivoj R.BeliC +4 位作者 Yiqi Zhang Yongdong Li Tao Wang Zhen-Nan Tian Qi-Dai Chen 《Frontiers of physics》 2025年第4期221-228,共8页
An edge soliton is a localized bound state that arises from the balance between diffraction broadening and nonlinearity-induced self-focusing.It typically resides either at the edge or at the domain wall of a lattice ... An edge soliton is a localized bound state that arises from the balance between diffraction broadening and nonlinearity-induced self-focusing.It typically resides either at the edge or at the domain wall of a lattice system.To the best of our knowledge,most reported edge solitons have been observed in conservative Hermitian systems;whether stable edge solitons can exist in non-Hermitian systems remains an open question.In this work,we utilize a photonic lattice that naturally exhibits type-II Dirac cones and introduce a domain wall by carefully configuring gains and losses at the three sites within each unit cell.Surprisingly,edge states localized at the domain wall can exhibit entirely real propagation constants.Building on these edge states,we demonstrate the existence of edge solitons that can propagate stably over distances significantly exceeding those in the experimental settings adopted in this study.Although these solitons eventually couple with the bulk states and ultimately collapse,they exhibit remarkable resilience.Our findings establish that a domain wall supporting loss-resistant edge solitons,which can also evade the skin effect,is achievable in non-Hermitian systems.This discovery holds promising potential for the development of compact functional optical devices. 展开更多
关键词 type-ii Dirac cones non-Hermitian optics edge solitons
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One-dimensional core/shell radial heterojunction with cascade type-II energyband alignment for enhanced broadband photodetection 被引量:1
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作者 Yi Ma Chunxiang Xu +5 位作者 Mengyang Wu Fumeng Zhang Xiaoxuan Wang Jianqi Dong Qiannan Cui Zengliang Shi 《Light(Advanced Manufacturing)》 2024年第3期130-141,共12页
Constructing a one-dimensional(1D)core/shell heterostructure is a rational and efficient way to integrate multiple functional materials into a single device,in which a distinct and reliable interface and suitable ener... Constructing a one-dimensional(1D)core/shell heterostructure is a rational and efficient way to integrate multiple functional materials into a single device,in which a distinct and reliable interface and suitable energy-band alignment play important roles in optoelectronic applications.Here,using a typical magnetron sputtering system,we constructed a 1D ZnO/CdS/CdTe core/shell nanorod arrays radial heterojunction with a well-designed cascade type-II energy band alignment and improved the broadband photodetector(PD)performance.The well-formed shell layers compensated for the defect states on the ZnO surface and extended the photoresponse range from ultraviolet to visible and near-infrared.Moreover,reliable and distinct heterointerfaces with a cascade type-II energy band alignment can guarantee more stable carrier migration and reduce energy loss,promoting effective photogenerated charge carrier separation and resulting in an enhanced photoresponse.The optimised 1D ZnO/CdS/CdTe core/shell heterojunction PD exhibited a fast photoresponse at 0 V bias with high responsivity and detectivity.These results provide an important reference for the rational design and controllable synthesis of multifunctional optoelectronic nanodevices. 展开更多
关键词 Magnetron sputtering ZnO/CdS/CdTe core/shell Radial heterojunction type-ii energy band Broadband photodetector
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Pure-blue emissive ZnSe/Cd_(x)Zn_(1-x)S/ZnS quantum dots with type-II core-shell structure for display application
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作者 Mingrui Liu Chenhui Wang +3 位作者 Peng Huang Jinhua He Muhammad Ramzan Haizheng Zhong 《Nano Research》 SCIE EI CSCD 2024年第12期10476-10482,共7页
Blue emissive quantum dots are key materials in fabricating quantum-dot light-emitting diodes for display applications.Up to date,most of the previous blue emissive quantum dots are based on quantum dots with type-I c... Blue emissive quantum dots are key materials in fabricating quantum-dot light-emitting diodes for display applications.Up to date,most of the previous blue emissive quantum dots are based on quantum dots with type-I core-shell structure.In this work,we report pure-blue emissive ZnSe/Cd_(x)Zn_(1-x)S/ZnS quantum dots with type-II core-shell structure,which show high photoluminescence quantum yield over 90%.The type-II structure was investigated by applying time-resolved photoluminescence and transient absorption measurements,illustrating the extended photoluminescence decay lifetime of ZnSe/Cd_(x)Zn_(1-x)S quantum dots as well as the transition of bleaching peak from the valence band of ZnSe to the conduction band of CdZnS.We further fabricated ZnSe/Cd_(x)Zn_(1-x)S/ZnS quantum dots based electroluminescence devices,achieving a maximum external quantum efficiency of 6.7%and a maximum luminance of 39,766 cd·m^(-2). 展开更多
关键词 quantum dots blue emitter type-ii DISPLAY core shell
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Structure-based development of potent and selective type-II kinase inhibitors of RIPK1
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作者 Ying Qin Dekang Li +16 位作者 Chunting Qi Huaijiang Xiang Huyan Meng Jingli Liu Shaoqing Zhou Xinyu Gong Ying Li Guifang Xu Rui Zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen Lifeng Pan Ying Li Li Tan 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第1期319-334,共16页
Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allo... Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allosteric RIPK1 inhibitors(RIPK1i)have been developed,and some of them have already advanced into clinical evaluation.Recently,selective RIPK1i that interact with both the allosteric pocket and the ATP-binding site of RIPK1 have started to emerge.Here,we report the rational development of a new series of type-II RIPK1i based on the rediscovery of a reported but mechanistically atypical RIPK3i.We also describe the structure-guided lead optimization of a potent,selective,and orally bioavailable RIPK1i,62,which exhibits extraordinary efficacies in mouse models of acute or chronic inflammatory diseases.Collectively,62 provides a useful tool for evaluating RIPK1 in animal disease models and a promising lead for further drug development. 展开更多
关键词 RIPK1 NECROPTOSIS type-ii kinase inhibitors Rational design Lead optimization Structure‒activity relationship ANTI-INFLAMMATION Preclinical drug discovery
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1例糖尿病合并复杂皮肤软组织感染患者的药学监护 被引量:1
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作者 刘瑛 杨秀萍 吴俊 《医药导报》 CAS 北大核心 2025年第1期121-124,共4页
目的探讨2型糖尿病合并复杂性皮肤及软组织感染患者的药学监护及意义。方法临床药师全程参与1例2型糖尿病合并复杂性皮肤及软组织感染患者的诊疗过程,开展药学查房,评估患者病情及用药情况,协助医师制定药物治疗方案和及时调整用药,并... 目的探讨2型糖尿病合并复杂性皮肤及软组织感染患者的药学监护及意义。方法临床药师全程参与1例2型糖尿病合并复杂性皮肤及软组织感染患者的诊疗过程,开展药学查房,评估患者病情及用药情况,协助医师制定药物治疗方案和及时调整用药,并实施药学监护,处理不良反应。结果患者感染有效控制,并发症消失,血糖恢复正常。结论临床药师通过参与临床治疗实践,协助医师制定药物治疗方案并实施药学监护,有利于提高糖尿病合并复杂皮肤软组织感染患者的药物疗效和用药安全。 展开更多
关键词 糖尿病 2型 复杂性皮肤及软组织感染 低蛋白血症 药学监护
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