AIM: To clarify whether subclassification of the type VI pit pattern on the basis of magnifying colonoscopy findings is useful in determining the type and depth of invasion of colorectal neoplasms.METHODS: We retrospe...AIM: To clarify whether subclassification of the type VI pit pattern on the basis of magnifying colonoscopy findings is useful in determining the type and depth of invasion of colorectal neoplasms.METHODS: We retrospectively analyzed 272 colorectal neoplasms (117 dysplasias and 155 submucosal invasive carcinomas; 228 patients) with a type V pit pattern [type VI, n = 202; type VN, n = 70 (Kudo and Tsuruta classification system)]. We divided lesions with a type VI pit pattern into two subclasses, mildly irregular lesions and severely irregular lesions, according to the prominent and detailed magnifying colonoscopy findings. We examined the relation between these two subclasses and histology/invasion depth.RESULTS: One hundred and four lesions (51.5%) were judged to be mildly irregular, and 98 lesions (48.5%) were judged to be severely irregular. Ninety-seven (93.3%) mildly irregular lesions showed dysplasias or submucosal invasion of less than 1000 μm (SM < 1000 μm). Fifty-five (56.1%) severely irregular lesions showed submucosal invasion equal to or deeper than 1000 μm (SM ≥ 1000 μm). Mild irregularity was found significantly more often in dysplasias or lesions with SM < 1000 μm than in lesions with SM ≥ 1000 μm (P < 0.01).CONCLUSION: Subclassification of the type VI pit pattern is useful for identifying dysplasias or lesions with SM < 1000 μm.展开更多
The case study based on Qinling Mountains in Shaanxi Province of China, in virtue of the information from TM image, classifies the land types and analyzes their spatial and temporal differential law, and puts forward ...The case study based on Qinling Mountains in Shaanxi Province of China, in virtue of the information from TM image, classifies the land types and analyzes their spatial and temporal differential law, and puts forward three structural patterns of land types in mountainous areas, namely, spatial, quantitative and qualitative structures of mountainous land types. Furthermore, it has been noticed that the analysis of structural patterns can disclose the heterogeneity and orderliness of combination of land types, which can lay the theoretic foundation for comprehensively recognizing ecological characteristics and succession law of structure and function of land types. After the all-around comparative analysis, an optimal allocation of land use in Qinling Mountains has been put forward according to the principle of sustainable development and landscape ecology, which can lay the scientific foundation in practice for the structural adjustment and distribution optimization from the macro level to micro level.展开更多
With the rapid increase of the number and influence of floating population in China,it is urgently needed to understand the regional types of China＇s floating population and their spatial characteristics. After revie...With the rapid increase of the number and influence of floating population in China,it is urgently needed to understand the regional types of China＇s floating population and their spatial characteristics. After reviewing the current methods for identifying regional types of floating population,this paper puts forward a new composite-index identification method and its modification version which is consisted of two indexes of the net migration rate and gross migration rate. Then,the traditional single-index and the new composite-index identification methods are empirically tested to explore their spatial patterns and characteristics by using China＇s 2000 census data at county level. The results show：（1） The composite-index identification method is much better than traditional single-index method because it can measure the migration direction and scale of floating simultaneously,and in particular it can identify the unique regional types of floating population with large scale of immigration and emigration. （2） The modified composite-index identification method,by using the share of a region＇s certain type of floating population to the total in China as weights,can effectively correct the over-or under-estimated errors due to the rather large or small total population of a region. （3） The spatial patterns of different regional types of China＇s floating population are closely related to the regional differentiation of their natural environment,population density and socio-economic development level. The three active regional types of floating population are mainly located in the eastern part of China with lower elevation,more than 800 mm precipitation,rather higher population densities and economic development levels.展开更多
Petrography and mineral chemistry of ninety-eight ordinary chondrites from Grove Mountains （GRV）, Antarctica, were presented and their. Weathering effect, shock metamorphism and type distribution patterns were discu...Petrography and mineral chemistry of ninety-eight ordinary chondrites from Grove Mountains （GRV）, Antarctica, were presented and their. Weathering effect, shock metamorphism and type distribution patterns were discussed in this study. Among them, six are unequilibrated ordinary chondrites, including 3 H3 and 3 L3 ; and 92 meteorites are equilibrated ordinary chondrites, including 24 H-group （ 13 H4, 10 H5, 1 H6）, 64 L-group （2 L4, 44 L5, 18 L6） and 4 LL-group （3 LL4, 1 LL5）. Most GRV ehondrites （ 〉 90% ） displayed minor weathering effect （ W1 and W2）. About half of the meteorites experienced severe shock metamorphism. They commonly contain shock-induced melt veins and pockets. These heavily shocked meteorites provide us with natural samples for study of high-pressure polymorphs of minerals. In addition, the Grove Mountains collection seems to have more abundant unequilibrated and L group ordinary ehondrites compared to the US Antarctic meteorite collection which were mainly found along the Transantarctic Mountains.展开更多
Purpose-The design goal for the tracking interval of high-speed railway trains in China is 3 min,but it is difficult to achieve,and it is widely believed that it is mainly limited by the tracking interval of train arr...Purpose-The design goal for the tracking interval of high-speed railway trains in China is 3 min,but it is difficult to achieve,and it is widely believed that it is mainly limited by the tracking interval of train arrivals.If the train arrival tracking interval can be compressed,it will be beneficial for China's high-speed railway to achieve a 3-min train tracking interval.The goal of this article is to study how to compress the train arrival tracking interval.Design/methodologylapproach-By simulating the process of dense train groups arriving at the station and stopping,the headway between train arrivals at the station was calculated,and the pattern of train arrival headway was obtained,changing the traditional understanding that the train arrival headway is considered the main factor limiting the headway of trains.Findings-When the running speed of trains is high,the headway between trains is short,the length of the station approach throat area is considerable and frequent train arrivals at the station,the arrival headway for the first group or several groups of trains will exceed the headway,but the subsequent sets of trains will havea headway equal to the arrival headway.This convergence characteristic is obtained by appropriately increasing the running time.Originality/value-According to this pattern,there is no need to overly emphasize the impact of train arrival headway on the headway.This plays an important role in compressing train headway and improving high-speedrailwaycapacity.展开更多
Background: Depression is a common mental disorder. Globally, more than 340 million people of all ages suffer from depression. The aim of our study was to determine the association between major dietary patterns and d...Background: Depression is a common mental disorder. Globally, more than 340 million people of all ages suffer from depression. The aim of our study was to determine the association between major dietary patterns and depression among type 2 diabetes patients. Methods: This cross-sectional study was conducted among 480 type 2 diabetes patients attending primary healthcare centers in Gaza Strip, Palestine. The depression, anxiety, stress scales (DASS, 21-items) questionnaire was used to measure the score of depression. The participants’ demographic, socioeconomic and medical history data was collected and the 98-items semi-quantitative food frequency questionnaire was used for evaluating the dietary patterns. Statistical analysis was performed using SPSS version 20. Results: Based on depression scale, 29.0% of type 2 diabetes patients had depression, (58.3% females, and 41.7% males). The prevalence of mild, moderate, severe, and very severe depression was 11.7%, 8.5%, 6.7%, and 2.1%, respectively. Furthermore, two major dietary patterns were identified by factor analysis: The Western, and the grains-vegetables, and fruits patterns. After adjusting for the potential confounders, patients in the lowest tertile (T1) of the grains-vegetables, and fruits dietary pattern had a lower odds for depression (OR 0.763 95% CI (0.667 - 0.871), P value = 0.001);where as a higher odds for healthy (OR 1.443 95% CI (1.131 - 1.839), P value = 0.004), compared to those in the highest tertile (T3). Conclusion: The grains-vegetables, and fruits dietary pattern may be associated with a lower prevalence of depression, and has been shown to be the healthiest dietary pattern among type 2 diabetes patients.展开更多
As a member of the Frizzled family, Frizzled3 (FZD3) is a receptor of the canonical Wnt signaling pathway and plays a vital role in mammalian hair follicle developmental processes. However, its effects on wool traits ...As a member of the Frizzled family, Frizzled3 (FZD3) is a receptor of the canonical Wnt signaling pathway and plays a vital role in mammalian hair follicle developmental processes. However, its effects on wool traits are not clear. The objectives of this study were to identify the single nucleotide polymorphisms (SNPs) and the expression patterns of FZD3 gene, and then to determine whether it affected wool traits of Chinese Merino sheep (Xinjiang Type) or not. PCR-single stranded conformational polymorphism (PCR-SSCP) and sequencing were used to identify mutation loci, and general linear model (GLM) with SAS 9.1 was used for the association analysis between wool traits and SNPs. Quantitative real-time PCR (qRT-PCR) was used to investigate FZD3 gene expression levels. The results showed that six exons of FZD3 gene were amplified and two mutation loci were identified in exon 1 (NC_019459.2: g.101771685 T>C (SNP1)) and exon 3 (NC_019459.2: g.101810848, A>C (SNP2)), respectively. Association analysis showed that SNP1 was significantly associated with mean fiber diameter (MFD)(P=0.04) and live weight (LW)(P=0.0004), SNP2 was significantly associated with greasy fleece weight (GFW)(P=0.04). The expression level of FZD3 gene in skin tissues of the superfine wool (SF) group was significantly lower (P<0.05) than that of the fine wool (F) group. Moreover, it had a higher expression level (P<0.01) in skin tissues than in other tissues of Chinese Merino ewes. While, its expression level had a fluctuant expression in skin tissues at different developmental stages of embryos and born lambs, with the highest expression levels (P<0.01) at the 65th day of embryos. Our study revealed the genetic relationship between FZD3 variants and wool traits and two identified SNPs might serve as potential and valuable genetic markers for sheep breeding and lay a molecular genetic foundation for sheep marker-assisted selection (MAS).展开更多
The purpose of this study was to classify current forest cover types,and to investigate stand development patterns for natural forests in six areas in northern Baekdudaegan,South Korea.Twenty-eight independent forest ...The purpose of this study was to classify current forest cover types,and to investigate stand development patterns for natural forests in six areas in northern Baekdudaegan,South Korea.Twenty-eight independent forest communities were aggregated into eight forest cover types by species composition in the overstory of each forest community.The forest cover types were of mixed mesophytic,‘‘others’ ’ deciduous,Quercus mongolica dominant,Q.mongolica pure,Pinus densiflora–Q.mongolica,P.densiflora,Betula ermanii,and Q.mongolica–P.koraiensis.The ecological information was organized by importance value and species diversity for each forest type.Based on the correlation between species diversity index and the abundance of Q.mongolica plus P.densiflora for corresponding forest cover types,we compared the developmental process and approximate successional pathway between each cover type.The P.densiflora forest cover type changes into the P.densiflora–Q.mongolica cover type,followed by the Q.mongolica dominant cover type through continuous invasion of the oak trees.Furthermore,the Q.mongolica pure cover type would spread toward the Q.mongolica dominant cover type with a mixture of various deciduous tree species.The Q.mongolica dominant cover type progresses through the other deciduous cover types to the mixed mesophytic cover type with diversified composition and structure.On the mid to lower slopes,with loamy soils and good moisture conditions,various deciduous forest types should progress,by ecological succession,toward the mixed mesophytic cover type without any further disturbance.展开更多
OBJECTIVE: To investigate the clinical differentiation of spleen-deficiency pattern(SDP), a group of symptoms and signs defined in terms of Traditional Chinese Medicine for its clinical practice.METHODS: Peripheral ve...OBJECTIVE: To investigate the clinical differentiation of spleen-deficiency pattern(SDP), a group of symptoms and signs defined in terms of Traditional Chinese Medicine for its clinical practice.METHODS: Peripheral venous blood(> 3 m L) was collected from each of six type 2 diabetes mellitus(T2DM)-SDP patients and six healthy volunteers. After the isolation of peripheral white blood cells(PWBCs), total RNA was extracted, and quality control was performed on all RNA samples. Microarray experiments were conducted using the Agilent human whole genome gene chip, and genes demonstrating differential expression were screened. Bioinformatics analysis was conducted on these genes using several online databases.RESULTS: We screened a total of 175 differentially expressed genes(DEGs), of which 111(63%) were down-regulated and 64(37%) were up-regulated in T2DM-SDP patients compared with healthy controls. Among the 175 genes, 158 had biological function annotations: 46(29%) were directly related to an individual's immune regulation or response, 25(16%) were associated with substance and energy metabolism of PWBCs which could also indirectly influence immunity, and the remaining87(55%) were involved in a variety of PWBC biological processes that might eventually influence the immune function. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that the DEGs were predominantly enriched in seven immune-related pathways. Hierarchical cluster analysis identified gene expression patterns that were distinguishable between the two study groups.CONCLUSION: Our results suggest that T2DM-SDP patients experience significant hypoimmunity and/or immune dysfunctions, and possess a specific gene expression profile. These findings offer new insights into SDP and the clinical pattern differentiation of T2DM-SDP.展开更多
Diabetes mellitus is the chronic disorder emerging as major world health problem which increases the rate of morbidity and mortality. The aim of the present study was to ascertain patterns of prescription of oral hypo...Diabetes mellitus is the chronic disorder emerging as major world health problem which increases the rate of morbidity and mortality. The aim of the present study was to ascertain patterns of prescription of oral hypoglycemic agents to type 2 diabetic patients attending a university hospital, and to assess patient compliance. A prospective, observational and non comparative study was conducted in 200 established diabetes mellitus type 2 patients attending outpatient department at Majeedia Hospital, New Delhi, India. Prescriptions from registered patients were included in the study. Once the consultation by the physician was over, the prescriptions were reviewed and the patients were interviewed. The information was collected in an inhouse designed documentation proforma. In a pool of 200 type 2 diabetics, more than half were female (n=106, 53%). The mean age of the patients were found to be 50.4 ± 11.7 years and mean body mass index, 25.8 ± 4.4 kg/m2. A total of 432 oral hypoglycemic agents were prescribed to the patients. Highly significant number of patients were prescribed combination therapy, (n=143, 71.5%) as compared to monotherapy (n=57, 28.5%),展开更多
基金a grant from the Japanese Society of Gastro-enterological Endoscopy, Chugoku Branch
文摘AIM: To clarify whether subclassification of the type VI pit pattern on the basis of magnifying colonoscopy findings is useful in determining the type and depth of invasion of colorectal neoplasms.METHODS: We retrospectively analyzed 272 colorectal neoplasms (117 dysplasias and 155 submucosal invasive carcinomas; 228 patients) with a type V pit pattern [type VI, n = 202; type VN, n = 70 (Kudo and Tsuruta classification system)]. We divided lesions with a type VI pit pattern into two subclasses, mildly irregular lesions and severely irregular lesions, according to the prominent and detailed magnifying colonoscopy findings. We examined the relation between these two subclasses and histology/invasion depth.RESULTS: One hundred and four lesions (51.5%) were judged to be mildly irregular, and 98 lesions (48.5%) were judged to be severely irregular. Ninety-seven (93.3%) mildly irregular lesions showed dysplasias or submucosal invasion of less than 1000 μm (SM < 1000 μm). Fifty-five (56.1%) severely irregular lesions showed submucosal invasion equal to or deeper than 1000 μm (SM ≥ 1000 μm). Mild irregularity was found significantly more often in dysplasias or lesions with SM < 1000 μm than in lesions with SM ≥ 1000 μm (P < 0.01).CONCLUSION: Subclassification of the type VI pit pattern is useful for identifying dysplasias or lesions with SM < 1000 μm.
基金Key project on Knowledge Innovation of Chinese Academy of Sciences, KZCX2-310-05
文摘The case study based on Qinling Mountains in Shaanxi Province of China, in virtue of the information from TM image, classifies the land types and analyzes their spatial and temporal differential law, and puts forward three structural patterns of land types in mountainous areas, namely, spatial, quantitative and qualitative structures of mountainous land types. Furthermore, it has been noticed that the analysis of structural patterns can disclose the heterogeneity and orderliness of combination of land types, which can lay the theoretic foundation for comprehensively recognizing ecological characteristics and succession law of structure and function of land types. After the all-around comparative analysis, an optimal allocation of land use in Qinling Mountains has been put forward according to the principle of sustainable development and landscape ecology, which can lay the scientific foundation in practice for the structural adjustment and distribution optimization from the macro level to micro level.
基金Foundation： Knowledge Innovation Program of the Chinese Academy of Sciences, No.KZCX2-YW-322, National Natural Science Foundation of China, No.40971102 The National Science and Technology Support Plan, No.2006BAJ11B02-04
文摘With the rapid increase of the number and influence of floating population in China,it is urgently needed to understand the regional types of China＇s floating population and their spatial characteristics. After reviewing the current methods for identifying regional types of floating population,this paper puts forward a new composite-index identification method and its modification version which is consisted of two indexes of the net migration rate and gross migration rate. Then,the traditional single-index and the new composite-index identification methods are empirically tested to explore their spatial patterns and characteristics by using China＇s 2000 census data at county level. The results show：（1） The composite-index identification method is much better than traditional single-index method because it can measure the migration direction and scale of floating simultaneously,and in particular it can identify the unique regional types of floating population with large scale of immigration and emigration. （2） The modified composite-index identification method,by using the share of a region＇s certain type of floating population to the total in China as weights,can effectively correct the over-or under-estimated errors due to the rather large or small total population of a region. （3） The spatial patterns of different regional types of China＇s floating population are closely related to the regional differentiation of their natural environment,population density and socio-economic development level. The three active regional types of floating population are mainly located in the eastern part of China with lower elevation,more than 800 mm precipitation,rather higher population densities and economic development levels.
基金supported by the Doctor's Foundation of Hunan University of Science and Technology(Grant No.E50806)
文摘Petrography and mineral chemistry of ninety-eight ordinary chondrites from Grove Mountains （GRV）, Antarctica, were presented and their. Weathering effect, shock metamorphism and type distribution patterns were discussed in this study. Among them, six are unequilibrated ordinary chondrites, including 3 H3 and 3 L3 ; and 92 meteorites are equilibrated ordinary chondrites, including 24 H-group （ 13 H4, 10 H5, 1 H6）, 64 L-group （2 L4, 44 L5, 18 L6） and 4 LL-group （3 LL4, 1 LL5）. Most GRV ehondrites （ 〉 90% ） displayed minor weathering effect （ W1 and W2）. About half of the meteorites experienced severe shock metamorphism. They commonly contain shock-induced melt veins and pockets. These heavily shocked meteorites provide us with natural samples for study of high-pressure polymorphs of minerals. In addition, the Grove Mountains collection seems to have more abundant unequilibrated and L group ordinary ehondrites compared to the US Antarctic meteorite collection which were mainly found along the Transantarctic Mountains.
基金State Railway Corporation of China Limited under the Science and Technology Research and Development Programme(2021X007)China Academy of Railway Research(2021YJ012)+1 种基金National Natural Science Foundation of China(52302417)Natural Science Foundation of Sichuan Province of China(2023NSFSC0906).
文摘Purpose-The design goal for the tracking interval of high-speed railway trains in China is 3 min,but it is difficult to achieve,and it is widely believed that it is mainly limited by the tracking interval of train arrivals.If the train arrival tracking interval can be compressed,it will be beneficial for China's high-speed railway to achieve a 3-min train tracking interval.The goal of this article is to study how to compress the train arrival tracking interval.Design/methodologylapproach-By simulating the process of dense train groups arriving at the station and stopping,the headway between train arrivals at the station was calculated,and the pattern of train arrival headway was obtained,changing the traditional understanding that the train arrival headway is considered the main factor limiting the headway of trains.Findings-When the running speed of trains is high,the headway between trains is short,the length of the station approach throat area is considerable and frequent train arrivals at the station,the arrival headway for the first group or several groups of trains will exceed the headway,but the subsequent sets of trains will havea headway equal to the arrival headway.This convergence characteristic is obtained by appropriately increasing the running time.Originality/value-According to this pattern,there is no need to overly emphasize the impact of train arrival headway on the headway.This plays an important role in compressing train headway and improving high-speedrailwaycapacity.
文摘Background: Depression is a common mental disorder. Globally, more than 340 million people of all ages suffer from depression. The aim of our study was to determine the association between major dietary patterns and depression among type 2 diabetes patients. Methods: This cross-sectional study was conducted among 480 type 2 diabetes patients attending primary healthcare centers in Gaza Strip, Palestine. The depression, anxiety, stress scales (DASS, 21-items) questionnaire was used to measure the score of depression. The participants’ demographic, socioeconomic and medical history data was collected and the 98-items semi-quantitative food frequency questionnaire was used for evaluating the dietary patterns. Statistical analysis was performed using SPSS version 20. Results: Based on depression scale, 29.0% of type 2 diabetes patients had depression, (58.3% females, and 41.7% males). The prevalence of mild, moderate, severe, and very severe depression was 11.7%, 8.5%, 6.7%, and 2.1%, respectively. Furthermore, two major dietary patterns were identified by factor analysis: The Western, and the grains-vegetables, and fruits patterns. After adjusting for the potential confounders, patients in the lowest tertile (T1) of the grains-vegetables, and fruits dietary pattern had a lower odds for depression (OR 0.763 95% CI (0.667 - 0.871), P value = 0.001);where as a higher odds for healthy (OR 1.443 95% CI (1.131 - 1.839), P value = 0.004), compared to those in the highest tertile (T3). Conclusion: The grains-vegetables, and fruits dietary pattern may be associated with a lower prevalence of depression, and has been shown to be the healthiest dietary pattern among type 2 diabetes patients.
基金supported by the National Natural Science Foundation of China (31360543 and 31760655)the earmarked fund for the China Agriculture Research System (CARS-39)+1 种基金the Open Project of Key Laboratory of Genetics Breeding and Reproduction of Xinjiang Cashmere and Wool Sheep, China (2016D03017)the Postdoctoral Science Foundation, China (2017M623287)
文摘As a member of the Frizzled family, Frizzled3 (FZD3) is a receptor of the canonical Wnt signaling pathway and plays a vital role in mammalian hair follicle developmental processes. However, its effects on wool traits are not clear. The objectives of this study were to identify the single nucleotide polymorphisms (SNPs) and the expression patterns of FZD3 gene, and then to determine whether it affected wool traits of Chinese Merino sheep (Xinjiang Type) or not. PCR-single stranded conformational polymorphism (PCR-SSCP) and sequencing were used to identify mutation loci, and general linear model (GLM) with SAS 9.1 was used for the association analysis between wool traits and SNPs. Quantitative real-time PCR (qRT-PCR) was used to investigate FZD3 gene expression levels. The results showed that six exons of FZD3 gene were amplified and two mutation loci were identified in exon 1 (NC_019459.2: g.101771685 T>C (SNP1)) and exon 3 (NC_019459.2: g.101810848, A>C (SNP2)), respectively. Association analysis showed that SNP1 was significantly associated with mean fiber diameter (MFD)(P=0.04) and live weight (LW)(P=0.0004), SNP2 was significantly associated with greasy fleece weight (GFW)(P=0.04). The expression level of FZD3 gene in skin tissues of the superfine wool (SF) group was significantly lower (P<0.05) than that of the fine wool (F) group. Moreover, it had a higher expression level (P<0.01) in skin tissues than in other tissues of Chinese Merino ewes. While, its expression level had a fluctuant expression in skin tissues at different developmental stages of embryos and born lambs, with the highest expression levels (P<0.01) at the 65th day of embryos. Our study revealed the genetic relationship between FZD3 variants and wool traits and two identified SNPs might serve as potential and valuable genetic markers for sheep breeding and lay a molecular genetic foundation for sheep marker-assisted selection (MAS).
基金support of ‘Forest Science&Technology Projects(Project No.S211012L030110)’ provided by Korea Forest Service
文摘The purpose of this study was to classify current forest cover types,and to investigate stand development patterns for natural forests in six areas in northern Baekdudaegan,South Korea.Twenty-eight independent forest communities were aggregated into eight forest cover types by species composition in the overstory of each forest community.The forest cover types were of mixed mesophytic,‘‘others’ ’ deciduous,Quercus mongolica dominant,Q.mongolica pure,Pinus densiflora–Q.mongolica,P.densiflora,Betula ermanii,and Q.mongolica–P.koraiensis.The ecological information was organized by importance value and species diversity for each forest type.Based on the correlation between species diversity index and the abundance of Q.mongolica plus P.densiflora for corresponding forest cover types,we compared the developmental process and approximate successional pathway between each cover type.The P.densiflora forest cover type changes into the P.densiflora–Q.mongolica cover type,followed by the Q.mongolica dominant cover type through continuous invasion of the oak trees.Furthermore,the Q.mongolica pure cover type would spread toward the Q.mongolica dominant cover type with a mixture of various deciduous tree species.The Q.mongolica dominant cover type progresses through the other deciduous cover types to the mixed mesophytic cover type with diversified composition and structure.On the mid to lower slopes,with loamy soils and good moisture conditions,various deciduous forest types should progress,by ecological succession,toward the mixed mesophytic cover type without any further disturbance.
基金Supported by the Administration of Traditional Chinese Medicine of Guangdong Province of China(Study on the Relevance Between the Pi-Deficiency Syndrome and Gene Differential Expression Profile of Immunity and Metabolism in Type 2 Diabetic MellitusNo.20123001)+8 种基金Special Funds from the Central Finance of China in Support of the Development of Local Colleges and Universities[Collaborative Innovation Platform for the Prevention and Treatment of Significant and Refractory Pi-Wei DiseasesEducational Finance Grant No.338(2013)]the National Natural Science Foundation of China(the Mechanism Study of Salivary Alpha Amylase Activity Change in Pi-Deficiency Syndrome Patients Based on the AMY1 Copy Number VariationN-Glycosylated Protein Level and β-Adrenergic Receptor ActivationNo.81102703)the Science and Technology Planning Project of Guangdong Province of China (miRNA as Material Basis for the New Hypothesis"Pi-Metabolism Relevance"and Study on the Molecular Mechanisms of Treating Metabolic Disorders Through PiNo.2013A032500005)
文摘OBJECTIVE: To investigate the clinical differentiation of spleen-deficiency pattern(SDP), a group of symptoms and signs defined in terms of Traditional Chinese Medicine for its clinical practice.METHODS: Peripheral venous blood(> 3 m L) was collected from each of six type 2 diabetes mellitus(T2DM)-SDP patients and six healthy volunteers. After the isolation of peripheral white blood cells(PWBCs), total RNA was extracted, and quality control was performed on all RNA samples. Microarray experiments were conducted using the Agilent human whole genome gene chip, and genes demonstrating differential expression were screened. Bioinformatics analysis was conducted on these genes using several online databases.RESULTS: We screened a total of 175 differentially expressed genes(DEGs), of which 111(63%) were down-regulated and 64(37%) were up-regulated in T2DM-SDP patients compared with healthy controls. Among the 175 genes, 158 had biological function annotations: 46(29%) were directly related to an individual's immune regulation or response, 25(16%) were associated with substance and energy metabolism of PWBCs which could also indirectly influence immunity, and the remaining87(55%) were involved in a variety of PWBC biological processes that might eventually influence the immune function. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that the DEGs were predominantly enriched in seven immune-related pathways. Hierarchical cluster analysis identified gene expression patterns that were distinguishable between the two study groups.CONCLUSION: Our results suggest that T2DM-SDP patients experience significant hypoimmunity and/or immune dysfunctions, and possess a specific gene expression profile. These findings offer new insights into SDP and the clinical pattern differentiation of T2DM-SDP.
文摘Diabetes mellitus is the chronic disorder emerging as major world health problem which increases the rate of morbidity and mortality. The aim of the present study was to ascertain patterns of prescription of oral hypoglycemic agents to type 2 diabetic patients attending a university hospital, and to assess patient compliance. A prospective, observational and non comparative study was conducted in 200 established diabetes mellitus type 2 patients attending outpatient department at Majeedia Hospital, New Delhi, India. Prescriptions from registered patients were included in the study. Once the consultation by the physician was over, the prescriptions were reviewed and the patients were interviewed. The information was collected in an inhouse designed documentation proforma. In a pool of 200 type 2 diabetics, more than half were female (n=106, 53%). The mean age of the patients were found to be 50.4 ± 11.7 years and mean body mass index, 25.8 ± 4.4 kg/m2. A total of 432 oral hypoglycemic agents were prescribed to the patients. Highly significant number of patients were prescribed combination therapy, (n=143, 71.5%) as compared to monotherapy (n=57, 28.5%),
