Wheat grain natural transverse sections of 12 periods were observed and analyzed using scanning electron micrographs technology and Bio-Quant system IV image analyzer in order to detect the developing process of A- an...Wheat grain natural transverse sections of 12 periods were observed and analyzed using scanning electron micrographs technology and Bio-Quant system IV image analyzer in order to detect the developing process of A- and B-type starch granules. In addition, the chemical composition and starch granule-bound proteins （SGPs） of A- and B-type starch granules were tested and analyzed. The results showed that A-type starch granules in wheat began from 3 d post anthesis （DPA） till grain maturing and B-type starch granules occured after 15 DPA till grain maturing. Approximately 98.5% of chemical compositions in both A- and B-type starch granules were amylose and amylopectin, and more than half of which were amylopectin. The amylopectin contents, average chain length, and chain length distribution （degree of polymerization〉 40） of amylopectin in A-type starch granules were significant higher than that of B-type starch granules. SGP-145, SGP-140, and SGP-26 kD were associated with A-type starch formation in wheat grain.展开更多
Objective To investigate the effect of Botulinum toxin type A(Botox)injection into the masseter muscle on mandibular development in rats.Methods 1228-day-old Wistar rats were divided into two groups as Botox group(n=6...Objective To investigate the effect of Botulinum toxin type A(Botox)injection into the masseter muscle on mandibular development in rats.Methods 1228-day-old Wistar rats were divided into two groups as Botox group(n=6)and control group(n=6)展开更多
The classification of township development types is an urgent problem that requires solution to enable the township to choose an appropriate development path.Using a township development classification method,we deter...The classification of township development types is an urgent problem that requires solution to enable the township to choose an appropriate development path.Using a township development classification method,we determine the township development types and their spatial patterns in Liaoning Province,China.The results showed that the patterns of township development types based on their general advantages had significant spatial differentiations.The planting,and livestock and poultry breeding township development types based on general advantages were mainly distributed across the central plain of Liaoning Province,China,and also concentrated in Dandong City−Dalian City along Yellow Sea coast,and in the northwest of Chaoyang City.The business and tourism,industry and mining,and residence township development types based on general advantages were distributed mainly along the Shenyang–Dalian Economic Belt in the central and southern Liaoning Province.The ecology township development type based on general advantages was mainly distributed in the eastern and western Liaoning Province to maintain regional ecological security.Township development types based on non-advantages were sporadically distributed in the middle and western Liaoning Province.Based on the classification and spatial patterns,the differences between the distribution of twonship development types and the plan for the major functional areas of Liaoning Province were proposed which could provide the basis for the optimization of the major functional areas.展开更多
Metabolic disease results from a complex interaction of many factors,including genetic,physiological,behavioral and environmental influences.The recent rate at which these diseases have increased suggests that environ...Metabolic disease results from a complex interaction of many factors,including genetic,physiological,behavioral and environmental influences.The recent rate at which these diseases have increased suggests that environmental and behavioral influences,rather than genetic causes,are fuelling the present epidemic.In this context,the developmental origins of health and disease hypothesis has highlighted the link between the periconceptual,fetal and early infant phases of life and the subsequent development of adult obesity and the metabolic syndrome.Although the mechanisms are yet to be fully elucidated,this programming was generally considered an irreversible change in developmental trajectory.Recent work in animal models suggests that developmental programming of metabolic disorders is potentially reversible by nutritional or targeted therapeutic interventions during the period of developmental plasticity.This review will discuss critical windows of developmental plasticity and possible avenues to ameliorate the development of postnatal metabolic disorders following an adverse early life environment.展开更多
There is consistent epidemiological evidence linking low birth weight, preterm birth and adverse fetal growth to an elevated risk of the metabolic syndrome (obesity, raised blood pressure, raised serum triglycerides, ...There is consistent epidemiological evidence linking low birth weight, preterm birth and adverse fetal growth to an elevated risk of the metabolic syndrome (obesity, raised blood pressure, raised serum triglycerides, lowered serum high-density lipoprotein cholesterol and impaired glucose tolerance or insulin resistance) and related disorders. This "fetal or developmental origins/programming of disease" concept is now well accepted but the "programming" mechanisms remain poorly understood. We reviewed the major evidence, implications and limitations of current hypotheses in interpreting developmental programming and discuss future research directions. Major current hypotheses to interpret developmental programming include: (1)thrifty phenotype; (2) postnatal accelerated or catchup growth; (3) glucocorticoid effects; (4) epigenetic changes; (5) oxidative stress; (6) prenatal hypoxia; (7) placental dysfunction; and (8) reduced stem cell number. Some hypothetical mechanisms (2, 4 and 8) could be driven by other upstream "driver" mechanisms. There is a lack of animal studies addressing multiple mechanisms simultaneously and a lack of strong evidence linking clinical outcomes to biomarkers of the proposed programming mechanisms in humans. There are needs for (1) experimental studies addressing multiple hypothetical mechanisms simultaneously; and (2) prospective pregnancy cohort studies linking biomarkers of the proposed mechanisms to clinical outcomes or surrogate biomarker endpoints. A better understanding of the programming mechanisms is a prerequisite for developing early life interventions to arrest the increasing epidemic of the metabolic syndrome, type 2 diabetes and other related disorders.展开更多
After entering the information-based society, profound reform has happened in the business pattern of enterprises, and thecompetitive mode between traditional enterprises has been transformed into the competition betw...After entering the information-based society, profound reform has happened in the business pattern of enterprises, and thecompetitive mode between traditional enterprises has been transformed into the competition between supply chains in nowadays. The liquorindustry in Luzhou is the pillar industry of economy, which involves “Luzhou Old Cellar”, “Ichiro Liquor”and other large-scale enterpriseswith well-known brands. Besides, many small and medium-sized enterprises are developing and flourishing in Luzhou. Compared with thedevelopment of large enterprises, the development of small and medium sized enterprises has more uncertainty and risks. At present, Luzhou Cityis setting about to build Huangyi into a liquor centralized zone, which is also a clusterization strategy for industry development of Luzhou liquor.For Luzhou Liquor Zone, the implementation of supply chain management of small and medium-sized enterprises can greatly reduce the cost ofenterprises and improve effi ciency of operation. The growth and development of small and medium-sized enterprises in Luzhou Liquor Zone andthe promotion of advantages of industrial clusters are closely related to the risks of the supply chain.展开更多
目的:探究髋关节镜手术治疗临界型发育性髋关节发育不良(borderline developmental dysplasia of the hip,BDDH)患者的早期疗效及安全性。方法:选取2020年1月至2022年12月确诊为BDDH的患者111例,根据手术方法分为两组,其中63例患者行关...目的:探究髋关节镜手术治疗临界型发育性髋关节发育不良(borderline developmental dysplasia of the hip,BDDH)患者的早期疗效及安全性。方法:选取2020年1月至2022年12月确诊为BDDH的患者111例,根据手术方法分为两组,其中63例患者行关节镜手术为关节镜组,男22例,女41例,年龄(35.67±6.83)岁;48例患者行髋臼周围截骨术(periacetabular osteotomy,PAO)为PAO组,男18例,女30例,年龄(36.85±7.10)岁。记录两组患者的手术时间、住院时间、出血量、康复时间、并发症发生率、再手术率。测量并记录两组患者影像学指标。分别采用改良Harris髋关节功能评分(modified Harris hip score,mHHS)、非骨关节炎髋关节评分(nonarthritic hip score,NAHS)、髋关节结果评分日常生活能力量表(hip outcome score activity of daily living scale,HOS-ADL)评估患者术前及术后的髋关节功能及生活质量。结果:所有患者获得随访,时间为12个月。关节镜组患者的手术时间(90.43±9.85)min、住院时间(4.32±0.56)d及康复时间(15.22±2.15)周、出血量(25.69±6.57)ml、发生并发症15例均低于PAO组(117.25±15.83)min、(5.81±0.92)d、(21.10±3.74)周、(358.52±126.73)ml、30例,差异均有统计学意义(P<0.05)。关节镜组治疗后末次随访外侧中心边缘角(lateral center edge angle,LCEA)为(19.82±1.90)°、前方中心边缘角(anterior center edge angle,ACEA)为(20.01±1.85)°均较治疗前(21.43±2.10)°、(21.54±2.05)°下降,但PAO组治疗后末次随访LCEA(33.03±3.45)°、ACEA为(33.48±4.22)°均较治疗前上升,差异均有统计学意义(P<0.05)。关节镜组的T?nnis角治疗后(11.05±1.83)°较治疗前上升,PAO组治疗后末次随访(2.98±0.75)°较治疗前下降,差异均有统计学意义(P<0.05)。关节镜组治疗后外凸指数(30.68±2.85)及T?nnis分级较治疗前均有改善,α角治疗后(38.79±4.27)°较治疗前明显下降,差异有统计学意义(P<0.05);PAO组治疗后外凸指数(15.03±2.18)、α角(53.58±6.02)较治疗前均明显下降,差异有统计学意义(P<0.05)。关节镜组治疗后末次随访mHSS评分(86.41±7.33)分均高于PAO组(81.02±6.49)分,差异有统计学意义(P<0.05)。关节镜组治疗后6个月NAHS为(69.83±6.53)分、HOS-ADL评分(78.84±7.39)分高于PAO组(64.10±6.02)分、(75.31±7.01)分,差异有统计学意义(P<0.01);关节镜组治疗后末次随访NAHS为(87.63±7.60)分、HOS-ADL评分(88.94±8.11)分高于PAO组(81.63±7.03)分、(83.63±7.92)分,差异均有统计学意义(P<0.05)。结论:髋关节镜手术相较于PAO手术,治疗BDDH患者具有更好的早中期临床疗效;但PAO在改善BDDH患者的髋臼影像学指标方面更具优势,而髋关节镜仅改善患者α角。同时髋关节镜手术对患者造成的创伤更小,减少出血量,更易于患者的后续恢复。展开更多
Smoking during pregnancy is a major source of fetal exposure to numerous harmful agents present in tobacco smoke. Lung development involves complex biochemical processes resulting in dramatic changes which continue ev...Smoking during pregnancy is a major source of fetal exposure to numerous harmful agents present in tobacco smoke. Lung development involves complex biochemical processes resulting in dramatic changes which continue even after birth. In addition to type I cells which form the blood-air barrier, type II alveolar epithelial (AE) cells have important and diverse functions related to immunological protection and stabilization of the alveolus through synthesis and secretion of the pulmonary surfactant. Apoptosis or programmed cells death is an important physiological process during lung embryogenesis and for the proper maintenance of homeostasis. Caspases are proteases that play important roles in regulating apoptosis. Caspase-3 is the key executioner caspase in the cascade of events leading to cell death by apoptosis. We explored the hypothesis that cigarette smoke extract (CSE) induces apoptosis in fetal rat lung type II AE cells by activation of caspase-3. To analyze these factors, isolated fetal rat lung type II AE cells were used. The cells were exposed to different concentrations of CSE (5%, 10% or 15%) (v/v) for 60 min. The results of the present study showed that CSE induced apoptosis in fetal rat lung type II AE cells with a significant increase (p 0.05) in caspase-3 activity and decrease in cell proliferation at CSE concentrations of 10% and 15% (v/v). These observations indicate that cigarette smoke extract induces apoptosis by activation of caspase-3 in fetal rat lung type II AE cells in a dose-dependent manner and may potentially alter the regulated development of the lung and the appearance of the surfactant-producing type II alveolar cells which are critical for the establishment of adequate gas exchange at birth.展开更多
目的探讨生物型人工全髋关节置换术（total hip arthroplasty,THA）中伴或不伴转子下短缩截骨治疗CroweⅣ型髋关节发育不良（developmental dysplasia of the hip,DDH）的临床特点差异。方法回顾分析2006年1月-2012年3月符合选择标准的2...目的探讨生物型人工全髋关节置换术（total hip arthroplasty,THA）中伴或不伴转子下短缩截骨治疗CroweⅣ型髋关节发育不良（developmental dysplasia of the hip,DDH）的临床特点差异。方法回顾分析2006年1月-2012年3月符合选择标准的21例（21髋）CroweⅣ型DDH患者临床资料。患者均行THA,其中9例术中行转子下短缩截骨（截骨组）,12例未行截骨（未截骨组）。两组除术前双下肢长度差值差异有统计学意义（t=—3.170,P=0.005）外,患者性别、年龄、身体质量指数及术前Harris评分等一般资料比较,差异均无统计学意义（P〉0.05）。记录并比较两组手术时间、失血量、术后引流量及并发症,并行影像学及临床疗效评估。结果截骨组患者手术时间、失血量及术后引流量均多于未截骨组（P〈0.05）。两组切口均Ⅰ期愈合;术后截骨组1例（1髋）出现一过性坐骨神经症状。患者均获随访,随访时间28-88个月,平均53个月。X线片复查示,截骨组截骨面均于3-6个月愈合;两组随访期间均无假体松动、脱位等发生。末次随访时,截骨组及未截骨组髋关节Harris评分分别为（90.67±4.06）、（92.17±3.27）分,组间比较差异无统计学意义（t=—0.938,P=0.360）。截骨组及未截骨组双下肢长度差值分别为（0.22±0.26）、（0.18±0.27）cm,组间比较差异无统计学意义（t=107.000,P=0.546）;截骨组6例、未截骨组5例存在下肢不等长。截骨组1例存在大腿部疼痛,未截骨组2例Trendelenburg征阳性。结论 THA治疗CroweⅣ型DDH可显著改善患者关节功能,恢复患肢长度。根据术前模板测量、下肢短缩程度和术中软组织牵拉程度情况选择是否行转子下短缩截骨术,可获得较好疗效。展开更多
基金supported by the National Natural Science Foundation of China (30860145)
文摘Wheat grain natural transverse sections of 12 periods were observed and analyzed using scanning electron micrographs technology and Bio-Quant system IV image analyzer in order to detect the developing process of A- and B-type starch granules. In addition, the chemical composition and starch granule-bound proteins （SGPs） of A- and B-type starch granules were tested and analyzed. The results showed that A-type starch granules in wheat began from 3 d post anthesis （DPA） till grain maturing and B-type starch granules occured after 15 DPA till grain maturing. Approximately 98.5% of chemical compositions in both A- and B-type starch granules were amylose and amylopectin, and more than half of which were amylopectin. The amylopectin contents, average chain length, and chain length distribution （degree of polymerization〉 40） of amylopectin in A-type starch granules were significant higher than that of B-type starch granules. SGP-145, SGP-140, and SGP-26 kD were associated with A-type starch formation in wheat grain.
文摘Objective To investigate the effect of Botulinum toxin type A(Botox)injection into the masseter muscle on mandibular development in rats.Methods 1228-day-old Wistar rats were divided into two groups as Botox group(n=6)and control group(n=6)
基金Under the auspices of the National Key Research and Development Program of China(No.2018YFD1100101)the National Natural Science Foundation of China(No.41771106,41171092)。
文摘The classification of township development types is an urgent problem that requires solution to enable the township to choose an appropriate development path.Using a township development classification method,we determine the township development types and their spatial patterns in Liaoning Province,China.The results showed that the patterns of township development types based on their general advantages had significant spatial differentiations.The planting,and livestock and poultry breeding township development types based on general advantages were mainly distributed across the central plain of Liaoning Province,China,and also concentrated in Dandong City−Dalian City along Yellow Sea coast,and in the northwest of Chaoyang City.The business and tourism,industry and mining,and residence township development types based on general advantages were distributed mainly along the Shenyang–Dalian Economic Belt in the central and southern Liaoning Province.The ecology township development type based on general advantages was mainly distributed in the eastern and western Liaoning Province to maintain regional ecological security.Township development types based on non-advantages were sporadically distributed in the middle and western Liaoning Province.Based on the classification and spatial patterns,the differences between the distribution of twonship development types and the plan for the major functional areas of Liaoning Province were proposed which could provide the basis for the optimization of the major functional areas.
基金Supported by Health Research Council of New Zealand,Marsden Fund of the Royal SocietyFoundation for Research Science and TechnologyNational Research Centre for Growth and Development
文摘Metabolic disease results from a complex interaction of many factors,including genetic,physiological,behavioral and environmental influences.The recent rate at which these diseases have increased suggests that environmental and behavioral influences,rather than genetic causes,are fuelling the present epidemic.In this context,the developmental origins of health and disease hypothesis has highlighted the link between the periconceptual,fetal and early infant phases of life and the subsequent development of adult obesity and the metabolic syndrome.Although the mechanisms are yet to be fully elucidated,this programming was generally considered an irreversible change in developmental trajectory.Recent work in animal models suggests that developmental programming of metabolic disorders is potentially reversible by nutritional or targeted therapeutic interventions during the period of developmental plasticity.This review will discuss critical windows of developmental plasticity and possible avenues to ameliorate the development of postnatal metabolic disorders following an adverse early life environment.
基金Supported by a Research Grant from the Canadian Institutes of Health Research (CIHR), Institute of Nutrition, Metabolism and Diabetes (CIHR Grant # 79896 - Luo ZC)partly by a Clinical Epidemiology Junior Scholar Award from the Fonds de la Recherche en Santé du Québec (FRSQ) (Luo ZC)partly by a FRSQ Senior Scholar Award (Nuyt AM)
文摘There is consistent epidemiological evidence linking low birth weight, preterm birth and adverse fetal growth to an elevated risk of the metabolic syndrome (obesity, raised blood pressure, raised serum triglycerides, lowered serum high-density lipoprotein cholesterol and impaired glucose tolerance or insulin resistance) and related disorders. This "fetal or developmental origins/programming of disease" concept is now well accepted but the "programming" mechanisms remain poorly understood. We reviewed the major evidence, implications and limitations of current hypotheses in interpreting developmental programming and discuss future research directions. Major current hypotheses to interpret developmental programming include: (1)thrifty phenotype; (2) postnatal accelerated or catchup growth; (3) glucocorticoid effects; (4) epigenetic changes; (5) oxidative stress; (6) prenatal hypoxia; (7) placental dysfunction; and (8) reduced stem cell number. Some hypothetical mechanisms (2, 4 and 8) could be driven by other upstream "driver" mechanisms. There is a lack of animal studies addressing multiple mechanisms simultaneously and a lack of strong evidence linking clinical outcomes to biomarkers of the proposed programming mechanisms in humans. There are needs for (1) experimental studies addressing multiple hypothetical mechanisms simultaneously; and (2) prospective pregnancy cohort studies linking biomarkers of the proposed mechanisms to clinical outcomes or surrogate biomarker endpoints. A better understanding of the programming mechanisms is a prerequisite for developing early life interventions to arrest the increasing epidemic of the metabolic syndrome, type 2 diabetes and other related disorders.
文摘After entering the information-based society, profound reform has happened in the business pattern of enterprises, and thecompetitive mode between traditional enterprises has been transformed into the competition between supply chains in nowadays. The liquorindustry in Luzhou is the pillar industry of economy, which involves “Luzhou Old Cellar”, “Ichiro Liquor”and other large-scale enterpriseswith well-known brands. Besides, many small and medium-sized enterprises are developing and flourishing in Luzhou. Compared with thedevelopment of large enterprises, the development of small and medium sized enterprises has more uncertainty and risks. At present, Luzhou Cityis setting about to build Huangyi into a liquor centralized zone, which is also a clusterization strategy for industry development of Luzhou liquor.For Luzhou Liquor Zone, the implementation of supply chain management of small and medium-sized enterprises can greatly reduce the cost ofenterprises and improve effi ciency of operation. The growth and development of small and medium-sized enterprises in Luzhou Liquor Zone andthe promotion of advantages of industrial clusters are closely related to the risks of the supply chain.
文摘目的:探究髋关节镜手术治疗临界型发育性髋关节发育不良(borderline developmental dysplasia of the hip,BDDH)患者的早期疗效及安全性。方法:选取2020年1月至2022年12月确诊为BDDH的患者111例,根据手术方法分为两组,其中63例患者行关节镜手术为关节镜组,男22例,女41例,年龄(35.67±6.83)岁;48例患者行髋臼周围截骨术(periacetabular osteotomy,PAO)为PAO组,男18例,女30例,年龄(36.85±7.10)岁。记录两组患者的手术时间、住院时间、出血量、康复时间、并发症发生率、再手术率。测量并记录两组患者影像学指标。分别采用改良Harris髋关节功能评分(modified Harris hip score,mHHS)、非骨关节炎髋关节评分(nonarthritic hip score,NAHS)、髋关节结果评分日常生活能力量表(hip outcome score activity of daily living scale,HOS-ADL)评估患者术前及术后的髋关节功能及生活质量。结果:所有患者获得随访,时间为12个月。关节镜组患者的手术时间(90.43±9.85)min、住院时间(4.32±0.56)d及康复时间(15.22±2.15)周、出血量(25.69±6.57)ml、发生并发症15例均低于PAO组(117.25±15.83)min、(5.81±0.92)d、(21.10±3.74)周、(358.52±126.73)ml、30例,差异均有统计学意义(P<0.05)。关节镜组治疗后末次随访外侧中心边缘角(lateral center edge angle,LCEA)为(19.82±1.90)°、前方中心边缘角(anterior center edge angle,ACEA)为(20.01±1.85)°均较治疗前(21.43±2.10)°、(21.54±2.05)°下降,但PAO组治疗后末次随访LCEA(33.03±3.45)°、ACEA为(33.48±4.22)°均较治疗前上升,差异均有统计学意义(P<0.05)。关节镜组的T?nnis角治疗后(11.05±1.83)°较治疗前上升,PAO组治疗后末次随访(2.98±0.75)°较治疗前下降,差异均有统计学意义(P<0.05)。关节镜组治疗后外凸指数(30.68±2.85)及T?nnis分级较治疗前均有改善,α角治疗后(38.79±4.27)°较治疗前明显下降,差异有统计学意义(P<0.05);PAO组治疗后外凸指数(15.03±2.18)、α角(53.58±6.02)较治疗前均明显下降,差异有统计学意义(P<0.05)。关节镜组治疗后末次随访mHSS评分(86.41±7.33)分均高于PAO组(81.02±6.49)分,差异有统计学意义(P<0.05)。关节镜组治疗后6个月NAHS为(69.83±6.53)分、HOS-ADL评分(78.84±7.39)分高于PAO组(64.10±6.02)分、(75.31±7.01)分,差异有统计学意义(P<0.01);关节镜组治疗后末次随访NAHS为(87.63±7.60)分、HOS-ADL评分(88.94±8.11)分高于PAO组(81.63±7.03)分、(83.63±7.92)分,差异均有统计学意义(P<0.05)。结论:髋关节镜手术相较于PAO手术,治疗BDDH患者具有更好的早中期临床疗效;但PAO在改善BDDH患者的髋臼影像学指标方面更具优势,而髋关节镜仅改善患者α角。同时髋关节镜手术对患者造成的创伤更小,减少出血量,更易于患者的后续恢复。
文摘Smoking during pregnancy is a major source of fetal exposure to numerous harmful agents present in tobacco smoke. Lung development involves complex biochemical processes resulting in dramatic changes which continue even after birth. In addition to type I cells which form the blood-air barrier, type II alveolar epithelial (AE) cells have important and diverse functions related to immunological protection and stabilization of the alveolus through synthesis and secretion of the pulmonary surfactant. Apoptosis or programmed cells death is an important physiological process during lung embryogenesis and for the proper maintenance of homeostasis. Caspases are proteases that play important roles in regulating apoptosis. Caspase-3 is the key executioner caspase in the cascade of events leading to cell death by apoptosis. We explored the hypothesis that cigarette smoke extract (CSE) induces apoptosis in fetal rat lung type II AE cells by activation of caspase-3. To analyze these factors, isolated fetal rat lung type II AE cells were used. The cells were exposed to different concentrations of CSE (5%, 10% or 15%) (v/v) for 60 min. The results of the present study showed that CSE induced apoptosis in fetal rat lung type II AE cells with a significant increase (p 0.05) in caspase-3 activity and decrease in cell proliferation at CSE concentrations of 10% and 15% (v/v). These observations indicate that cigarette smoke extract induces apoptosis by activation of caspase-3 in fetal rat lung type II AE cells in a dose-dependent manner and may potentially alter the regulated development of the lung and the appearance of the surfactant-producing type II alveolar cells which are critical for the establishment of adequate gas exchange at birth.
文摘目的探讨生物型人工全髋关节置换术（total hip arthroplasty,THA）中伴或不伴转子下短缩截骨治疗CroweⅣ型髋关节发育不良（developmental dysplasia of the hip,DDH）的临床特点差异。方法回顾分析2006年1月-2012年3月符合选择标准的21例（21髋）CroweⅣ型DDH患者临床资料。患者均行THA,其中9例术中行转子下短缩截骨（截骨组）,12例未行截骨（未截骨组）。两组除术前双下肢长度差值差异有统计学意义（t=—3.170,P=0.005）外,患者性别、年龄、身体质量指数及术前Harris评分等一般资料比较,差异均无统计学意义（P〉0.05）。记录并比较两组手术时间、失血量、术后引流量及并发症,并行影像学及临床疗效评估。结果截骨组患者手术时间、失血量及术后引流量均多于未截骨组（P〈0.05）。两组切口均Ⅰ期愈合;术后截骨组1例（1髋）出现一过性坐骨神经症状。患者均获随访,随访时间28-88个月,平均53个月。X线片复查示,截骨组截骨面均于3-6个月愈合;两组随访期间均无假体松动、脱位等发生。末次随访时,截骨组及未截骨组髋关节Harris评分分别为（90.67±4.06）、（92.17±3.27）分,组间比较差异无统计学意义（t=—0.938,P=0.360）。截骨组及未截骨组双下肢长度差值分别为（0.22±0.26）、（0.18±0.27）cm,组间比较差异无统计学意义（t=107.000,P=0.546）;截骨组6例、未截骨组5例存在下肢不等长。截骨组1例存在大腿部疼痛,未截骨组2例Trendelenburg征阳性。结论 THA治疗CroweⅣ型DDH可显著改善患者关节功能,恢复患肢长度。根据术前模板测量、下肢短缩程度和术中软组织牵拉程度情况选择是否行转子下短缩截骨术,可获得较好疗效。
