A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary ...A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary micro-variables evolution at different temperatures and their interaction.The dislocation density was incorporated into the model to capture the effect of creep deformation on precipitation.Quantitative transmission electron microscopy and experimental data obtained from a previous study were used to calibrate the model.Subsequently,the developed constitutive model was implemented in the finite element(FE)software ABAQUS via the user subroutines for TSCA process simulation and the springback prediction of an integral panel.A TSCA test was performed.The result shows that the maximum radius deviation between the formed plate and the simulation results is less than 0.4 mm,thus validating the effectiveness of the developed constitutive model and FE model.展开更多
Limb length discrepancy(LLD)is a common orthopedic condition that can result in significant functional impairment,pain,and cosmetic deformities.Current reconstructive techniques for severe LLD are primarily based on c...Limb length discrepancy(LLD)is a common orthopedic condition that can result in significant functional impairment,pain,and cosmetic deformities.Current reconstructive techniques for severe LLD are primarily based on callus distraction,which is a time-consuming process that can lead to complications,such as significant infection,joint stiffness,and stress fractures.To reduce the therapeutic time and minimize the risk of complications,we investigated the use of vascularized bone flaps as a technical supplement to callus distraction in the reconstruction of short limbs.We present two cases of severe LLD in the upper and lower legs,in which a twostage reconstruction approach was used.In the first stage,external fixation was applied to the affected limb to correct the soft tissue length and convert the short deformity into a bone defect.In the second stage,the bone defect was reconstructed using bilateral(patient A)or unilateral(patient B)free vascularized fibula bone grafts.Both patients had complete survival of the fibular grafts without stress fractures,and bone consolidation took 8 months(patient A)and 4 months(patient B).Compared to the traditional callus distraction,the two-stage approach was found to be more time-saving and reliable.The entire reconstructive scheme required 18 and 4 months for patients A and B,respectively,whereas the traditional callus distraction required 41 and 17 months,respectively.These findings suggest that the use of vascularized bone flaps as a technical supplement for callus distraction may provide an effective and efficient alternative for the treatment of severe LLD.Further studies are needed to validate these results and assess the long-term outcomes of this approach.展开更多
Lexical analysis is a fundamental task in natural language processing,which involves several subtasks,such as word segmentation(WS),part-of-speech(POS)tagging,and named entity recognition(NER).Recent works have shown ...Lexical analysis is a fundamental task in natural language processing,which involves several subtasks,such as word segmentation(WS),part-of-speech(POS)tagging,and named entity recognition(NER).Recent works have shown that taking advantage of relatedness between these subtasks can be beneficial.This paper proposes a unified neural framework to address these subtasks simultaneously.Apart from the sequence tagging paradigm,the proposed method tackles the multitask lexical analysis via two-stage sequence span classification.Firstly,the model detects the word and named entity boundaries by multilabel classification over character spans in a sentence.Then,the authors assign POS labels and entity labels for words and named entities by multi-class classification,respectively.Furthermore,a Gated Task Transformation(GTT)is proposed to encourage the model to share valuable features between tasks.The performance of the proposed model was evaluated on Chinese and Thai public datasets,demonstrating state-of-the-art results.展开更多
Applying bio-oxidation waste solution(BOS)to chemical-biological two-stage oxidation process can significantly improve the bio-oxidation efficiency of arsenopyrite.This study aims to clarify the enhanced oxidation mec...Applying bio-oxidation waste solution(BOS)to chemical-biological two-stage oxidation process can significantly improve the bio-oxidation efficiency of arsenopyrite.This study aims to clarify the enhanced oxidation mechanism of arsenopyrite by evaluating the effects of physical and chemical changes of arsenopyrite in BOS chemical oxidation stage on mineral dissolution kinetics,as well as microbial growth activity and community structure composition in bio-oxidation stage.The results showed that the chemical oxidation contributed to destroying the physical and chemical structure of arsenopyrite surface and reducing the particle size,and led to the formation of nitrogenous substances on mineral surface.These chemical oxidation behaviors effectively promoted Fe^(3+)cycling in the bio-oxidation system and weakened the inhibitory effect of the sulfur film on ionic diffusion,thereby enhancing the dissolution kinetics of the arsenopyrite.Therefore,the bio-oxidation efficiency of arsenopyrite was significantly increased in the two-stage oxidation process.After 18 d,the two-stage oxidation process achieved total extraction rates of(88.8±2.0)%,(86.7±1.3)%,and(74.7±3.0)%for As,Fe,and S elements,respectively.These values represented a significant increase of(50.8±3.4)%,(47.1±2.7)%,and(46.0±0.7)%,respectively,compared to the one-stage bio-oxidation process.展开更多
BACKGROUND Transcrestal sinus floor elevation(TSFE)has been widely used in the oral clinic when the residual bone height(RBH)exceeds 5 mm.However,when there is insufficient RBH in the posterior maxilla,two-stage TSFE ...BACKGROUND Transcrestal sinus floor elevation(TSFE)has been widely used in the oral clinic when the residual bone height(RBH)exceeds 5 mm.However,when there is insufficient RBH in the posterior maxilla,two-stage TSFE may be an option.CASE SUMMARY This article introduces the concept of two-stage TSFE.Six patients had osseointegration failure after TSFE.For the first-stage surgery,we restricted the vertical bone augmentation as much as possible.At the second-stage surgery,the increased RBH was 3.28±1.55 mm,which was beneficial for surgery.Five implants functioned successfully on schedule,but one implant failed again during the healing period.A third surgery was performed,and the implant functioned successfully.CONCLUSION When RBH was less than 5 mm,two or more procedures of TSFE might result in a higher RBH.展开更多
BACKGROUND Only one case of liver transplantation for hepatic adenoma has previously been reported for patients with rupture and uncontrolled hemorrhage.We present the case of a massive ruptured hepatic adenoma with p...BACKGROUND Only one case of liver transplantation for hepatic adenoma has previously been reported for patients with rupture and uncontrolled hemorrhage.We present the case of a massive ruptured hepatic adenoma with persistent hemorrhagic shock and toxic liver syndrome which resulted in a two-stage liver transplantation.This is the first case of a two-stage liver transplantation performed for a ruptured hepatic adenoma.CASE SUMMARY A 23 years old African American female with a history of pre-diabetes and oral contraceptive presented to an outside facility complaining of right-sided chest pain and emesis for one day.She was found to be in hemorrhagic shock due to a massive ruptured hepatic hepatic adenoma.She underwent repeated embolizations with interventional radiology with ongoing hemorrhage and the development of renal failure,hepatic failure,and hemodynamic instability,known as toxic liver syndrome.In the setting of uncontrolled hemorrhage and toxic liver syndrome,a hepatectomy with porto-caval anastomosis was performed with liver transplantation 15 h later.She tolerated the anhepatic stage well,and has done well over one year later.CONCLUSION When toxic liver syndrome is recognized,liver transplantation with or withouthepatectomy should be considered before the patient becomes unstable.展开更多
Exploring the factors driving the decoupling of China’s sulfur dioxide(SO_(2))emissions from economic growth(DEI)is crucial for achieving sustainable development.By analyzing the decoupling indicators and driving fac...Exploring the factors driving the decoupling of China’s sulfur dioxide(SO_(2))emissions from economic growth(DEI)is crucial for achieving sustainable development.By analyzing the decoupling indicators and driving factors at both the generation and treatment stages of SO_(2),more effective targeted mitigation strategies can be developed.We employ the Tapio decoupling model and propose a two-stage method to examine the decoupling issues related to SO_(2).Our findings indicate that:①DEI shows a steady and significant improvement,with SO_(2)emission intensity identified as the primary driver.②for the decoupling of economic growth and SO_(2)generation,energy scale serves as the largest stimulator,while the effect of energy intensity changes from negative to positive,and pollution intensity is first positive and then negative.③For the decoupling of SO_(2)generation and SO_(2)removal,treatment efficiency leads as the largest promoter,followed by treatment intensity.Based on these results,this study recommends that China focuses more on enhancing clean energy utilization and the effectiveness of treatment processes.展开更多
BACKGROUND Two-stage revision is the most common treatment for chronic periprosthetic joint infection of the hip,involving a resection arthroplasty with or without placement of an antibiotic-loaded spacer,followed by ...BACKGROUND Two-stage revision is the most common treatment for chronic periprosthetic joint infection of the hip,involving a resection arthroplasty with or without placement of an antibiotic-loaded spacer,followed by antibiotic therapy before reimplantation.AIM To compare the outcomes and complications of two consecutive treatment protocols for two-stage revision arthroplasty of the infected hip:One using Girdlestone with an antibiotic holiday,the other using custom-made articulating spacers(CUMARS)without an antibiotic holiday.METHODS In this retrospective study,two consecutive cohorts were compared.Group A(2017-2020)underwent two-stage revision with a Girdlestone and an antibiotic holiday before reimplantation,while Group B(2020-2023)received CUMARS whenever possible,and no antibiotic holiday,or a Girdlestone if indicated.The primary outcome was successful infection eradication after one year.Secondary outcomes included surgical duration,length of hospital stay,weight-bearing allowance,discharge destination,and complications.RESULTS A total of 98 patients were included:39 patients in Group A and 59 patients in Group B.Successful infection eradication after one year was achieved in 69%of Group A and 83%of Group B(P=0.164).Patients in Group B were more frequently allowed to bear weight(64%vs 18%,P<0.001),had a shorter in-hospital stay(9 vs 16 days,P<0.001),and were more often discharged home after the first surgery(48%vs 24%,P=0.048).No significant differences were found in(mechanical)complications.CONCLUSION A protocol including CUMARS is a safe and effective treatment,offering faster recovery,shorter length of hospital stay,and enabling more patients to return home during the interval.This reduces strain on patients and the healthcare system,potentially saving costs,without compromising infection control or increasing(mechanical)complications.展开更多
Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growin...Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.展开更多
BACKGROUND Two-stage hepatectomy(TSH)is a well-established surgical technique,used to treat bilateral colorectal liver metastases(CRLM)with a small future liver remnant(FLR).However,in classical TSH,drop-out is report...BACKGROUND Two-stage hepatectomy(TSH)is a well-established surgical technique,used to treat bilateral colorectal liver metastases(CRLM)with a small future liver remnant(FLR).However,in classical TSH,drop-out is reported to be around 25%-40%,due to insufficient FLR increase or progression of disease.Trans-arterial radioembolization(TARE)has been described to control locally tumor growth of liver malignancies such as hepatocellular carcinoma,but it has been also reported to induce a certain degree of contralateral liver hypertrophy,even if at a lower rate compared to portal vein embolization or ligation.CASE SUMMARY Herein we report the case of a 75-year-old female patient,where TSH and TARE were combined to treat bilateral CRLM.According to computed tomography(CT)-scan,the patient had a hepatic lesion in segment VI-VII and two other confluent lesions in segment II-III.Therefore,one-stage posterior right sectionectomy plus left lateral sectionectomy(LLS)was planned.The liver volumetry estimated a FLR of 38%(segments I-IV-V-VIII).However,due to a more than initially planned,extended right resection,simultaneous LLS was not performed and the patient underwent selective TARE to segments II-III after the first surgery.The CT-scan performed after TARE showed a reduction of the treated lesion and a FLR increase of 55%.Carcinoembryonic antigen and CA 19.9 decreased significantly.Nearly three months later after the first surgery,LLS was performed and the patient was discharged without any postoperative complications.CONCLUSION According to this specific experience,TARE was used to induce liver hypertrophy and simultaneously control cancer progression in TSH settings for bilateral CRLM.展开更多
The development of efficient and clean heating technologies is crucial for reducing carbon emissions in regions with severe cold regions.This research designs a novel two-stage phase change heat storage coupled solar-...The development of efficient and clean heating technologies is crucial for reducing carbon emissions in regions with severe cold regions.This research designs a novel two-stage phase change heat storage coupled solar-air source heat pump heating system structure that is specifically designed for such regions.The two-stage heat storage device in this heating system expands the storage temperature range of solar heat.The utilization of the two-stage heat storage device not onlymakes up for the instability of the solar heating system,but can also directlymeet the building heating temperature,and can reduce the influence of low-temperature outdoor environments in severe cold regions on the heating performance of the air source heat pump by using solar energy.Therefore,the two-stage phase change heat storage coupled to the solar energy-air source heat pump heating system effectively improves the utilization rate of solar energy.A numerical model of the system components and their integration was developed using TRNSYS software in this study,and various performance aspects of the system were simulated and analyzed.The simulation results demonstrated that the two-stage heat storage device can effectively store solar energy,enabling its hierarchical utilization.The low-temperature solar energy stored by the two-stage phase change heat storage device enhances the coefficient of performance of the air source heat pump by 11.1%in severe cold conditions.Using the Hooke-Jeeves optimization method,the annual cost and carbon emissions are taken as optimization objectives,with the optimized solar heat supply accounting for 52.5%.This study offers valuable insights into operational strategies and site selection for engineering applications,providing a solid theoretical foundation for the widespread implementation of this system in severe cold regions.展开更多
Integrated-energy systems(IESs)are key to advancing renewable-energy utilization and addressing environmental challenges.Key components of IESs include low-carbon,economic dispatch and demand response,for maximizing r...Integrated-energy systems(IESs)are key to advancing renewable-energy utilization and addressing environmental challenges.Key components of IESs include low-carbon,economic dispatch and demand response,for maximizing renewable-energy consumption and supporting sustainable-energy systems.User participation is central to demand response;however,many users are not inclined to engage actively;therefore,the full potential of demand response remains unrealized.User satisfaction must be prioritized in demand-response assessments.This study proposed a two-stage,capacity-optimization configuration method for user-level energy systems con-sidering thermal inertia and user satisfaction.This method addresses load coordination and complementary issues within the IES and seeks to minimize the annual,total cost for determining equipment capacity configurations while introducing models for system thermal inertia and user satisfaction.Indoor heating is adjusted,for optimizing device output and load profiles,with a focus on typical,daily,economic,and environmental objectives.The studyfindings indicate that the system thermal inertia optimizes energy-system scheduling considering user satisfaction.This optimization mitigates environmental concerns and enhances clean-energy integration.展开更多
Dear Editor,We read with great interest the article by Abou Samra et al[1] about the management of selected keratoconus cases.We would like to congratulate the authors for the originality of this study, but in our opi...Dear Editor,We read with great interest the article by Abou Samra et al[1] about the management of selected keratoconus cases.We would like to congratulate the authors for the originality of this study, but in our opinion there are some points that need to be clarified. The authors included in this study 13 eyes of 11 patients. This number seems to be too small, to make a definite conclusion.展开更多
As future ship system,hybrid energy ship system has a wide range of application prospects for solving the serious energy crisis.However,current optimization scheduling works lack the consideration of sea conditions an...As future ship system,hybrid energy ship system has a wide range of application prospects for solving the serious energy crisis.However,current optimization scheduling works lack the consideration of sea conditions and navigational circumstances.There-fore,this paper aims at establishing a two-stage optimization framework for hybrid energy ship power system.The proposed framework considers multiple optimizations of route,speed planning,and energy management under the constraints of sea conditions during navigation.First,a complex hybrid ship power model consisting of diesel generation system,propulsion system,energy storage system,photovoltaic power generation system,and electric boiler system is established,where sea state information and ship resistance model are considered.With objective optimization functions of cost and greenhouse gas(GHG)emissions,a two-stage optimization framework consisting of route planning,speed scheduling,and energy management is constructed.Wherein the improved A-star algorithm and grey wolf optimization algorithm are introduced to obtain the optimal solutions for route,speed,and energy optimization scheduling.Finally,simulation cases are employed to verify that the proposed two-stage optimization scheduling model can reduce load energy consumption,operating costs,and carbon emissions by 17.8%,17.39%,and 13.04%,respectively,compared with the non-optimal control group.展开更多
BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major...BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major blood vessels remains a substantial clinical challenge.Traditionally,these cases often require open abdominal surgery or combined organ resections,and in some instances,the tumors are considered unresectable.Currently,no reports have described the resection of such tumors via laparoscopy.CASE SUMMARY A 35-year-old woman was admitted to our hospital after the incidental discovery of a retroperitoneal space-occupying lesion.Imaging revealed a mass with the celiac axis and superior mesenteric artery passing through it.A neurogenic tumor was suspected,with ganglioneuroma being the most likely diagnosis.Following comprehensive preoperative preparation,the retroperitoneal tumor was resected using a three-dimensional laparoscopy combined with an organ suspension technique.The surgical approach involved incising the tumor along the vascular axis and conducting meticulous,vascular-preserving tumor excision.The operation lasted approximately 458 minutes,with an estimated blood loss of 50 mL.The patient was discharged on the 8th postoperative day.A transient liver injury occurred after surgery but improved rapidly.After 11 months of postoperative follow-up,no complications or tumor recurrence were observed.CONCLUSION This case illustrates the feasibility of minimally invasive laparoscopic resection for retroperitoneal ganglioneuromas encasing major blood vessels.展开更多
In order to address the synergistic optimization of energy efficiency improvement in the waste incineration power plant(WIPP)and renewable energy accommodation,an electricity-hydrogen-waste multi-energy system integra...In order to address the synergistic optimization of energy efficiency improvement in the waste incineration power plant(WIPP)and renewable energy accommodation,an electricity-hydrogen-waste multi-energy system integrated with phase change material(PCM)thermal storage is proposed.First,a thermal energy management framework is constructed,combining PCM thermal storage with the alkaline electrolyzer(AE)waste heat recovery and the heat pump(HP),while establishing a PCM-driven waste drying system to enhance the efficiency of waste incineration power generation.Next,a flue gas treatment method based on purification-separation-storage coordination is adopted,achieving spatiotemporal decoupling between waste incineration and flue gas treatment.Subsequently,a two-stage optimal dispatching strategy for the multi-energy system is developed:the first stage establishes a dayahead economic dispatch model with the objective of minimizing net system costs,while the second stage introduces model predictive control(MPC)to realize intraday rolling optimization.Finally,The optimal dispatching strategies under different scenarios are obtained using the Gurobi solver,followed by a comparative analysis of the optimized operational outcomes.Simulation results demonstrate that the proposed system optimizes the output and operational states of each unit,simultaneously reducing carbon trading costs while increasing electricity sales revenue.The proposed scheduling strategy demonstrates effective grid peak-shaving functionality,thereby simultaneously improving the system’s economic performance and operational flexibility while providing an innovative technical pathway for municipal solid waste(MSW)resource utilization and low-carbon transformation of energy systems.展开更多
The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction...The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.展开更多
Agriculture is a key facilitator of economic prosperity and nourishes the huge global population.To achieve sustainable agriculture,several factors should be considered,such as increasing nutrient and water efficiency...Agriculture is a key facilitator of economic prosperity and nourishes the huge global population.To achieve sustainable agriculture,several factors should be considered,such as increasing nutrient and water efficiency and/or improving soil health and quality.Using fertilizer is one of the fastest and easiest ways to improve the quality of nutrients inland and increase the effectiveness of crop yields.Fertilizer supplies most of the necessary nutrients for plants,and it is estimated that at least 30%-50%of crop yields is attributable to commercial fertilizer nutrient inputs.Fertilizer is always a major concern in achieving sustainable and efficient agriculture.Applying reasonable and customized fertilizerswill require a significant increase in the number of formulae,involving increasing costs and the accurate forecasting of the right time to apply the suitable formulae.An alternative solution is given by two-stage production planning under stochastic demand,which divides a planning schedule into two stages.The primary stage has non-existing demand information,the inputs of which are the proportion of raw materials needed for producing fertilizer products,the cost for purchasing materials,and the production cost.The total quantity of purchased material and produced products to be used in the blending process must be defined to meet as small as possible a paid cost.At the second stage,demand appears under multiple scenarios and their respective possibilities.This stage will provide a solution for each occurring scenario to achieve the best profit.The two-stage approach is presented in this paper,the mathematical model of which is based on linear integer programming.Considering the diversity of fertilizer types,themathematicalmodel can advise manufacturers about which products will generate as much as profit as possible.Specifically,two objectives are taken into account.First,the paper’s thesis focuses on minimizing overall system costs,e.g.,including inventory cost,purchasing cost,unit cost,and ordering cost at Stage 1.Second,the thesis pays attention tomaximizing total profit based on information from customer demand,as well as being informed regarding concerns about system cost at Stage 2.展开更多
In order to reduce the losses caused by tip-leakage flow, axisymmetric contouring is applied to the casing of a two-stage unshrouded high pressure turbine（HPT） of aero-engine in this paper. This investigation focuse...In order to reduce the losses caused by tip-leakage flow, axisymmetric contouring is applied to the casing of a two-stage unshrouded high pressure turbine（HPT） of aero-engine in this paper. This investigation focuses on the effects of contoured axisymmetric-casing on the blade tipleakage flow. While the size of tip clearance remains the same as the original design, the rotor casing and the blade tip are obtained with the same contoured arc shape. Numerical calculation results show that a promotion of 0.14% to the overall efficiency is achieved. Detailed analysis indicates that it reduces the entropy generation rate caused by the complex vortex structure in the rotor tip region, especially in the tip-leakage vortex. The low velocity region in the leading edge（LE） part of the tip gap is enlarged and the pressure side/tip junction separation bubble extends much further away from the leading edge in the clearance. So the blocking effect of pressure side/tip junction separation bubble on clearance flow prevents more flow on the tip pressure side from leaking to the suction side, which results in weaker leakage vortex and less associated losses.展开更多
AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(...AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.展开更多
基金supported by the National Key R&D Program of China(No.2021YFB3400900)the National Natural Science Foundation of China(Nos.52175373,52205435)+1 种基金Natural Science Foundation of Hunan Province,China(No.2022JJ40621)the Innovation Fund of National Commercial Aircraft Manufacturing Engineering Technology Center,China(No.COMACSFGS-2022-1875)。
文摘A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary micro-variables evolution at different temperatures and their interaction.The dislocation density was incorporated into the model to capture the effect of creep deformation on precipitation.Quantitative transmission electron microscopy and experimental data obtained from a previous study were used to calibrate the model.Subsequently,the developed constitutive model was implemented in the finite element(FE)software ABAQUS via the user subroutines for TSCA process simulation and the springback prediction of an integral panel.A TSCA test was performed.The result shows that the maximum radius deviation between the formed plate and the simulation results is less than 0.4 mm,thus validating the effectiveness of the developed constitutive model and FE model.
基金supported by the National Nature Science Foundation(grant nos.81871577 and 81971864)。
文摘Limb length discrepancy(LLD)is a common orthopedic condition that can result in significant functional impairment,pain,and cosmetic deformities.Current reconstructive techniques for severe LLD are primarily based on callus distraction,which is a time-consuming process that can lead to complications,such as significant infection,joint stiffness,and stress fractures.To reduce the therapeutic time and minimize the risk of complications,we investigated the use of vascularized bone flaps as a technical supplement to callus distraction in the reconstruction of short limbs.We present two cases of severe LLD in the upper and lower legs,in which a twostage reconstruction approach was used.In the first stage,external fixation was applied to the affected limb to correct the soft tissue length and convert the short deformity into a bone defect.In the second stage,the bone defect was reconstructed using bilateral(patient A)or unilateral(patient B)free vascularized fibula bone grafts.Both patients had complete survival of the fibular grafts without stress fractures,and bone consolidation took 8 months(patient A)and 4 months(patient B).Compared to the traditional callus distraction,the two-stage approach was found to be more time-saving and reliable.The entire reconstructive scheme required 18 and 4 months for patients A and B,respectively,whereas the traditional callus distraction required 41 and 17 months,respectively.These findings suggest that the use of vascularized bone flaps as a technical supplement for callus distraction may provide an effective and efficient alternative for the treatment of severe LLD.Further studies are needed to validate these results and assess the long-term outcomes of this approach.
基金supported by National Natural Science Foundation of China(Grant No.62266028,62266027,U21B2027,and U24A20334)Major Science and Technology Programs in Yunnan Province(Grant No.202302AD080003,202402AG050007,and 202303AP140008)+1 种基金Yunnan Province Basic Research Program(Grant No.202301AS070047,202301AT070471,and 202401BC070021)Kunming University of Science and Technology's"Double First-rate"construction joint project(Grant No.202201BE070001-021).
文摘Lexical analysis is a fundamental task in natural language processing,which involves several subtasks,such as word segmentation(WS),part-of-speech(POS)tagging,and named entity recognition(NER).Recent works have shown that taking advantage of relatedness between these subtasks can be beneficial.This paper proposes a unified neural framework to address these subtasks simultaneously.Apart from the sequence tagging paradigm,the proposed method tackles the multitask lexical analysis via two-stage sequence span classification.Firstly,the model detects the word and named entity boundaries by multilabel classification over character spans in a sentence.Then,the authors assign POS labels and entity labels for words and named entities by multi-class classification,respectively.Furthermore,a Gated Task Transformation(GTT)is proposed to encourage the model to share valuable features between tasks.The performance of the proposed model was evaluated on Chinese and Thai public datasets,demonstrating state-of-the-art results.
基金Project(52274348)supported by the National Natural Science Foundation of ChinaProject(2022JH1/10400024)supported by the Major Projects for the“Revealed Top”Science and Technology of Liaoning Province,China。
文摘Applying bio-oxidation waste solution(BOS)to chemical-biological two-stage oxidation process can significantly improve the bio-oxidation efficiency of arsenopyrite.This study aims to clarify the enhanced oxidation mechanism of arsenopyrite by evaluating the effects of physical and chemical changes of arsenopyrite in BOS chemical oxidation stage on mineral dissolution kinetics,as well as microbial growth activity and community structure composition in bio-oxidation stage.The results showed that the chemical oxidation contributed to destroying the physical and chemical structure of arsenopyrite surface and reducing the particle size,and led to the formation of nitrogenous substances on mineral surface.These chemical oxidation behaviors effectively promoted Fe^(3+)cycling in the bio-oxidation system and weakened the inhibitory effect of the sulfur film on ionic diffusion,thereby enhancing the dissolution kinetics of the arsenopyrite.Therefore,the bio-oxidation efficiency of arsenopyrite was significantly increased in the two-stage oxidation process.After 18 d,the two-stage oxidation process achieved total extraction rates of(88.8±2.0)%,(86.7±1.3)%,and(74.7±3.0)%for As,Fe,and S elements,respectively.These values represented a significant increase of(50.8±3.4)%,(47.1±2.7)%,and(46.0±0.7)%,respectively,compared to the one-stage bio-oxidation process.
基金the Wenzhou Science and Technology Bureau Projects,No.Y20190105.
文摘BACKGROUND Transcrestal sinus floor elevation(TSFE)has been widely used in the oral clinic when the residual bone height(RBH)exceeds 5 mm.However,when there is insufficient RBH in the posterior maxilla,two-stage TSFE may be an option.CASE SUMMARY This article introduces the concept of two-stage TSFE.Six patients had osseointegration failure after TSFE.For the first-stage surgery,we restricted the vertical bone augmentation as much as possible.At the second-stage surgery,the increased RBH was 3.28±1.55 mm,which was beneficial for surgery.Five implants functioned successfully on schedule,but one implant failed again during the healing period.A third surgery was performed,and the implant functioned successfully.CONCLUSION When RBH was less than 5 mm,two or more procedures of TSFE might result in a higher RBH.
文摘BACKGROUND Only one case of liver transplantation for hepatic adenoma has previously been reported for patients with rupture and uncontrolled hemorrhage.We present the case of a massive ruptured hepatic adenoma with persistent hemorrhagic shock and toxic liver syndrome which resulted in a two-stage liver transplantation.This is the first case of a two-stage liver transplantation performed for a ruptured hepatic adenoma.CASE SUMMARY A 23 years old African American female with a history of pre-diabetes and oral contraceptive presented to an outside facility complaining of right-sided chest pain and emesis for one day.She was found to be in hemorrhagic shock due to a massive ruptured hepatic hepatic adenoma.She underwent repeated embolizations with interventional radiology with ongoing hemorrhage and the development of renal failure,hepatic failure,and hemodynamic instability,known as toxic liver syndrome.In the setting of uncontrolled hemorrhage and toxic liver syndrome,a hepatectomy with porto-caval anastomosis was performed with liver transplantation 15 h later.She tolerated the anhepatic stage well,and has done well over one year later.CONCLUSION When toxic liver syndrome is recognized,liver transplantation with or withouthepatectomy should be considered before the patient becomes unstable.
基金the National Natural Science Foundation of China[Grant No.52270183].
文摘Exploring the factors driving the decoupling of China’s sulfur dioxide(SO_(2))emissions from economic growth(DEI)is crucial for achieving sustainable development.By analyzing the decoupling indicators and driving factors at both the generation and treatment stages of SO_(2),more effective targeted mitigation strategies can be developed.We employ the Tapio decoupling model and propose a two-stage method to examine the decoupling issues related to SO_(2).Our findings indicate that:①DEI shows a steady and significant improvement,with SO_(2)emission intensity identified as the primary driver.②for the decoupling of economic growth and SO_(2)generation,energy scale serves as the largest stimulator,while the effect of energy intensity changes from negative to positive,and pollution intensity is first positive and then negative.③For the decoupling of SO_(2)generation and SO_(2)removal,treatment efficiency leads as the largest promoter,followed by treatment intensity.Based on these results,this study recommends that China focuses more on enhancing clean energy utilization and the effectiveness of treatment processes.
文摘BACKGROUND Two-stage revision is the most common treatment for chronic periprosthetic joint infection of the hip,involving a resection arthroplasty with or without placement of an antibiotic-loaded spacer,followed by antibiotic therapy before reimplantation.AIM To compare the outcomes and complications of two consecutive treatment protocols for two-stage revision arthroplasty of the infected hip:One using Girdlestone with an antibiotic holiday,the other using custom-made articulating spacers(CUMARS)without an antibiotic holiday.METHODS In this retrospective study,two consecutive cohorts were compared.Group A(2017-2020)underwent two-stage revision with a Girdlestone and an antibiotic holiday before reimplantation,while Group B(2020-2023)received CUMARS whenever possible,and no antibiotic holiday,or a Girdlestone if indicated.The primary outcome was successful infection eradication after one year.Secondary outcomes included surgical duration,length of hospital stay,weight-bearing allowance,discharge destination,and complications.RESULTS A total of 98 patients were included:39 patients in Group A and 59 patients in Group B.Successful infection eradication after one year was achieved in 69%of Group A and 83%of Group B(P=0.164).Patients in Group B were more frequently allowed to bear weight(64%vs 18%,P<0.001),had a shorter in-hospital stay(9 vs 16 days,P<0.001),and were more often discharged home after the first surgery(48%vs 24%,P=0.048).No significant differences were found in(mechanical)complications.CONCLUSION A protocol including CUMARS is a safe and effective treatment,offering faster recovery,shorter length of hospital stay,and enabling more patients to return home during the interval.This reduces strain on patients and the healthcare system,potentially saving costs,without compromising infection control or increasing(mechanical)complications.
基金supported by the National Natural Science Foundation of China(No.62101587)the National Funded Postdoctoral Researcher Program of China(No.GZC20233578)。
文摘Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.
文摘BACKGROUND Two-stage hepatectomy(TSH)is a well-established surgical technique,used to treat bilateral colorectal liver metastases(CRLM)with a small future liver remnant(FLR).However,in classical TSH,drop-out is reported to be around 25%-40%,due to insufficient FLR increase or progression of disease.Trans-arterial radioembolization(TARE)has been described to control locally tumor growth of liver malignancies such as hepatocellular carcinoma,but it has been also reported to induce a certain degree of contralateral liver hypertrophy,even if at a lower rate compared to portal vein embolization or ligation.CASE SUMMARY Herein we report the case of a 75-year-old female patient,where TSH and TARE were combined to treat bilateral CRLM.According to computed tomography(CT)-scan,the patient had a hepatic lesion in segment VI-VII and two other confluent lesions in segment II-III.Therefore,one-stage posterior right sectionectomy plus left lateral sectionectomy(LLS)was planned.The liver volumetry estimated a FLR of 38%(segments I-IV-V-VIII).However,due to a more than initially planned,extended right resection,simultaneous LLS was not performed and the patient underwent selective TARE to segments II-III after the first surgery.The CT-scan performed after TARE showed a reduction of the treated lesion and a FLR increase of 55%.Carcinoembryonic antigen and CA 19.9 decreased significantly.Nearly three months later after the first surgery,LLS was performed and the patient was discharged without any postoperative complications.CONCLUSION According to this specific experience,TARE was used to induce liver hypertrophy and simultaneously control cancer progression in TSH settings for bilateral CRLM.
基金This work was supported by the project of the Research on Energy Consumption of Office Space in Colleges and Universities under the“Dual Carbon Target”(No.CJ202301006).
文摘The development of efficient and clean heating technologies is crucial for reducing carbon emissions in regions with severe cold regions.This research designs a novel two-stage phase change heat storage coupled solar-air source heat pump heating system structure that is specifically designed for such regions.The two-stage heat storage device in this heating system expands the storage temperature range of solar heat.The utilization of the two-stage heat storage device not onlymakes up for the instability of the solar heating system,but can also directlymeet the building heating temperature,and can reduce the influence of low-temperature outdoor environments in severe cold regions on the heating performance of the air source heat pump by using solar energy.Therefore,the two-stage phase change heat storage coupled to the solar energy-air source heat pump heating system effectively improves the utilization rate of solar energy.A numerical model of the system components and their integration was developed using TRNSYS software in this study,and various performance aspects of the system were simulated and analyzed.The simulation results demonstrated that the two-stage heat storage device can effectively store solar energy,enabling its hierarchical utilization.The low-temperature solar energy stored by the two-stage phase change heat storage device enhances the coefficient of performance of the air source heat pump by 11.1%in severe cold conditions.Using the Hooke-Jeeves optimization method,the annual cost and carbon emissions are taken as optimization objectives,with the optimized solar heat supply accounting for 52.5%.This study offers valuable insights into operational strategies and site selection for engineering applications,providing a solid theoretical foundation for the widespread implementation of this system in severe cold regions.
基金supported by the science and technology foundation of Guizhou province[2022]general 013the science and technology foundation of Guizhou province[2022]general 014+1 种基金the science and technology foundation of Guizhou province GCC[2022]016-1the educational technology foundation of Guizhou province[2022]043.
文摘Integrated-energy systems(IESs)are key to advancing renewable-energy utilization and addressing environmental challenges.Key components of IESs include low-carbon,economic dispatch and demand response,for maximizing renewable-energy consumption and supporting sustainable-energy systems.User participation is central to demand response;however,many users are not inclined to engage actively;therefore,the full potential of demand response remains unrealized.User satisfaction must be prioritized in demand-response assessments.This study proposed a two-stage,capacity-optimization configuration method for user-level energy systems con-sidering thermal inertia and user satisfaction.This method addresses load coordination and complementary issues within the IES and seeks to minimize the annual,total cost for determining equipment capacity configurations while introducing models for system thermal inertia and user satisfaction.Indoor heating is adjusted,for optimizing device output and load profiles,with a focus on typical,daily,economic,and environmental objectives.The studyfindings indicate that the system thermal inertia optimizes energy-system scheduling considering user satisfaction.This optimization mitigates environmental concerns and enhances clean-energy integration.
文摘Dear Editor,We read with great interest the article by Abou Samra et al[1] about the management of selected keratoconus cases.We would like to congratulate the authors for the originality of this study, but in our opinion there are some points that need to be clarified. The authors included in this study 13 eyes of 11 patients. This number seems to be too small, to make a definite conclusion.
基金supported by the National Natural Science Foundation of China under Grant 62473328by the Open Research Fund of Jiangsu Collaborative Innovation Center for Smart Distribution Network,Nanjing Institute of Technology under No.XTCX202203.
文摘As future ship system,hybrid energy ship system has a wide range of application prospects for solving the serious energy crisis.However,current optimization scheduling works lack the consideration of sea conditions and navigational circumstances.There-fore,this paper aims at establishing a two-stage optimization framework for hybrid energy ship power system.The proposed framework considers multiple optimizations of route,speed planning,and energy management under the constraints of sea conditions during navigation.First,a complex hybrid ship power model consisting of diesel generation system,propulsion system,energy storage system,photovoltaic power generation system,and electric boiler system is established,where sea state information and ship resistance model are considered.With objective optimization functions of cost and greenhouse gas(GHG)emissions,a two-stage optimization framework consisting of route planning,speed scheduling,and energy management is constructed.Wherein the improved A-star algorithm and grey wolf optimization algorithm are introduced to obtain the optimal solutions for route,speed,and energy optimization scheduling.Finally,simulation cases are employed to verify that the proposed two-stage optimization scheduling model can reduce load energy consumption,operating costs,and carbon emissions by 17.8%,17.39%,and 13.04%,respectively,compared with the non-optimal control group.
基金Supported by the Zhejiang Medical Science and Technology Project,No.2022KY1325 and No.2023KY381Public Welfare Project of Jinhua Science and Technology Plan,No.2023-4-084Major Project of Jinhua Science and Technology Plan,No.2023-3-066.
文摘BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major blood vessels remains a substantial clinical challenge.Traditionally,these cases often require open abdominal surgery or combined organ resections,and in some instances,the tumors are considered unresectable.Currently,no reports have described the resection of such tumors via laparoscopy.CASE SUMMARY A 35-year-old woman was admitted to our hospital after the incidental discovery of a retroperitoneal space-occupying lesion.Imaging revealed a mass with the celiac axis and superior mesenteric artery passing through it.A neurogenic tumor was suspected,with ganglioneuroma being the most likely diagnosis.Following comprehensive preoperative preparation,the retroperitoneal tumor was resected using a three-dimensional laparoscopy combined with an organ suspension technique.The surgical approach involved incising the tumor along the vascular axis and conducting meticulous,vascular-preserving tumor excision.The operation lasted approximately 458 minutes,with an estimated blood loss of 50 mL.The patient was discharged on the 8th postoperative day.A transient liver injury occurred after surgery but improved rapidly.After 11 months of postoperative follow-up,no complications or tumor recurrence were observed.CONCLUSION This case illustrates the feasibility of minimally invasive laparoscopic resection for retroperitoneal ganglioneuromas encasing major blood vessels.
文摘In order to address the synergistic optimization of energy efficiency improvement in the waste incineration power plant(WIPP)and renewable energy accommodation,an electricity-hydrogen-waste multi-energy system integrated with phase change material(PCM)thermal storage is proposed.First,a thermal energy management framework is constructed,combining PCM thermal storage with the alkaline electrolyzer(AE)waste heat recovery and the heat pump(HP),while establishing a PCM-driven waste drying system to enhance the efficiency of waste incineration power generation.Next,a flue gas treatment method based on purification-separation-storage coordination is adopted,achieving spatiotemporal decoupling between waste incineration and flue gas treatment.Subsequently,a two-stage optimal dispatching strategy for the multi-energy system is developed:the first stage establishes a dayahead economic dispatch model with the objective of minimizing net system costs,while the second stage introduces model predictive control(MPC)to realize intraday rolling optimization.Finally,The optimal dispatching strategies under different scenarios are obtained using the Gurobi solver,followed by a comparative analysis of the optimized operational outcomes.Simulation results demonstrate that the proposed system optimizes the output and operational states of each unit,simultaneously reducing carbon trading costs while increasing electricity sales revenue.The proposed scheduling strategy demonstrates effective grid peak-shaving functionality,thereby simultaneously improving the system’s economic performance and operational flexibility while providing an innovative technical pathway for municipal solid waste(MSW)resource utilization and low-carbon transformation of energy systems.
基金supported by the National Natural Science Foundation of China(No.51921004).
文摘The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.
文摘Agriculture is a key facilitator of economic prosperity and nourishes the huge global population.To achieve sustainable agriculture,several factors should be considered,such as increasing nutrient and water efficiency and/or improving soil health and quality.Using fertilizer is one of the fastest and easiest ways to improve the quality of nutrients inland and increase the effectiveness of crop yields.Fertilizer supplies most of the necessary nutrients for plants,and it is estimated that at least 30%-50%of crop yields is attributable to commercial fertilizer nutrient inputs.Fertilizer is always a major concern in achieving sustainable and efficient agriculture.Applying reasonable and customized fertilizerswill require a significant increase in the number of formulae,involving increasing costs and the accurate forecasting of the right time to apply the suitable formulae.An alternative solution is given by two-stage production planning under stochastic demand,which divides a planning schedule into two stages.The primary stage has non-existing demand information,the inputs of which are the proportion of raw materials needed for producing fertilizer products,the cost for purchasing materials,and the production cost.The total quantity of purchased material and produced products to be used in the blending process must be defined to meet as small as possible a paid cost.At the second stage,demand appears under multiple scenarios and their respective possibilities.This stage will provide a solution for each occurring scenario to achieve the best profit.The two-stage approach is presented in this paper,the mathematical model of which is based on linear integer programming.Considering the diversity of fertilizer types,themathematicalmodel can advise manufacturers about which products will generate as much as profit as possible.Specifically,two objectives are taken into account.First,the paper’s thesis focuses on minimizing overall system costs,e.g.,including inventory cost,purchasing cost,unit cost,and ordering cost at Stage 1.Second,the thesis pays attention tomaximizing total profit based on information from customer demand,as well as being informed regarding concerns about system cost at Stage 2.
文摘In order to reduce the losses caused by tip-leakage flow, axisymmetric contouring is applied to the casing of a two-stage unshrouded high pressure turbine（HPT） of aero-engine in this paper. This investigation focuses on the effects of contoured axisymmetric-casing on the blade tipleakage flow. While the size of tip clearance remains the same as the original design, the rotor casing and the blade tip are obtained with the same contoured arc shape. Numerical calculation results show that a promotion of 0.14% to the overall efficiency is achieved. Detailed analysis indicates that it reduces the entropy generation rate caused by the complex vortex structure in the rotor tip region, especially in the tip-leakage vortex. The low velocity region in the leading edge（LE） part of the tip gap is enlarged and the pressure side/tip junction separation bubble extends much further away from the leading edge in the clearance. So the blocking effect of pressure side/tip junction separation bubble on clearance flow prevents more flow on the tip pressure side from leaking to the suction side, which results in weaker leakage vortex and less associated losses.
文摘AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.
