Flexible X-ray detectors have garnered considerable attention owing to their extensive applications in three-dimensional (3D) image reconstruction, disease diagnosis and nondestructive testing^([1-3]). Conventional X-...Flexible X-ray detectors have garnered considerable attention owing to their extensive applications in three-dimensional (3D) image reconstruction, disease diagnosis and nondestructive testing^([1-3]). Conventional X-ray detectors typically employ active-matrix backplanes fabricated on rigid glass substrates, which integrate switching transistors and photodetectors^([4, 5]).展开更多
Based on the thermal network of the two-dimensional heterojunction bipolar transistors(HBTs) array, the thermal resistance matrix is presented, including the self-heating thermal resistance and thermal coupling resist...Based on the thermal network of the two-dimensional heterojunction bipolar transistors(HBTs) array, the thermal resistance matrix is presented, including the self-heating thermal resistance and thermal coupling resistance to describe the self-heating and thermal coupling effects, respectively.For HBT cells along the emitter length direction, the thermal coupling resistance is far smaller than the self-heating thermal resistance, and the peak junction temperature is mainly determined by the self-heating thermal resistance.However, the thermal coupling resistance is in the same order with the self-heating thermal resistance for HBT cells along the emitter width direction.Furthermore, the dependence of the thermal resistance matrix on cell spacing along the emitter length direction and cell spacing along the emitter width direction is also investigated, respectively.It is shown that the moderate increase of cell spacings along the emitter length direction and the emitter width direction could effectively lower the self-heating thermal resistance and thermal coupling resistance,and hence the peak junction temperature is decreased, which sheds light on adopting a two-dimensional non-uniform cell spacing layout to improve the uneven temperature distribution.By taking a 2 × 6 HBTs array for example, a twodimensional non-uniform cell spacing layout is designed, which can effectively lower the peak junction temperature and reduce the non-uniformity of the dissipated power.For the HBTs array with optimized layout, the high power-handling capability and thermal dissipation capability are kept when the bias voltage increases.展开更多
Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the ...Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this paper.First,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing process.Second,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR model.Finally,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation type.Theoretical analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR method.The recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR.展开更多
This paper studies the eigenfunction expansion method to solve the two dimensional （2D） elasticity problems based on the stress formulation. The fundamental system of partial differential equations of the 2D problem...This paper studies the eigenfunction expansion method to solve the two dimensional （2D） elasticity problems based on the stress formulation. The fundamental system of partial differential equations of the 2D problems is rewritten as an upper tri angular differential system based on the known results, and then the associated upper triangular operator matrix matrix is obtained. By further research, the two simpler com plete orthogonal systems of eigenfunctions in some space are obtained, which belong to the two block operators arising in the operator matrix. Then, a more simple and conve nient general solution to the 2D problem is given by the eigenfunction expansion method. Furthermore, the boundary conditions for the 2D problem, which can be solved by this method, are indicated. Finally, the validity of the obtained results is verified by a specific example.展开更多
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ...In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.展开更多
Driven by advancements in mobile internet technology,images have become a crucial data medium.Ensuring the security of image information during transmission has thus emerged as an urgent challenge.This study proposes ...Driven by advancements in mobile internet technology,images have become a crucial data medium.Ensuring the security of image information during transmission has thus emerged as an urgent challenge.This study proposes a novel image encryption algorithm specifically designed for grayscale image security.This research introduces a new Cantor diagonal matrix permutation method.The proposed permutation method uses row and column index sequences to control the Cantor diagonal matrix,where the row and column index sequences are generated by a spatiotemporal chaotic system named coupled map lattice(CML).The high initial value sensitivity of the CML system makes the permutation method highly sensitive and secure.Additionally,leveraging fractal theory,this study introduces a chaotic fractal matrix and applies this matrix in the diffusion process.This chaotic fractal matrix exhibits selfsimilarity and irregularity.Using the Cantor diagonal matrix and chaotic fractal matrix,this paper introduces a fast image encryption algorithm involving two diffusion steps and one permutation step.Moreover,the algorithm achieves robust security with only a single encryption round,ensuring high operational efficiency.Experimental results show that the proposed algorithm features an expansive key space,robust security,high sensitivity,high efficiency,and superior statistical properties for the ciphered images.Thus,the proposed algorithm not only provides a practical solution for secure image transmission but also bridges fractal theory with image encryption techniques,thereby opening new research avenues in chaotic cryptography and advancing the development of information security technology.展开更多
We read with the great interest the study by Ababneh et al in which inducedmesenchymal stem cell-derived exosomes were shown to exhibit a stronger andmore sustained anti-proliferative effect by inducing a senescence-l...We read with the great interest the study by Ababneh et al in which inducedmesenchymal stem cell-derived exosomes were shown to exhibit a stronger andmore sustained anti-proliferative effect by inducing a senescence-like state withoutapoptosis.The results obtained by the authors highlight the features of theeffects of senescent drift induction in surrounding tissues.In the light of thesefindings,the role of the properties of extracellular matrix and cellular glycocalyxin responses of human tumors to therapy remain uninvestigated.These extracellularbarriers appear to be significant obstacles to effective cancer therapy,especiallyin relation to the use of unique properties of tumor microenvironment forthe immunotherapy-resistant cancer treatment.展开更多
Peripheral nerve injury causes severe neuroinflammation and has become a global medical challenge.Previous research has demonstrated that porcine decellularized nerve matrix hydrogel exhibits excellent biological prop...Peripheral nerve injury causes severe neuroinflammation and has become a global medical challenge.Previous research has demonstrated that porcine decellularized nerve matrix hydrogel exhibits excellent biological properties and tissue specificity,highlighting its potential as a biomedical material for the repair of severe peripheral nerve injury;however,its role in modulating neuroinflammation post-peripheral nerve injury remains unknown.Here,we aimed to characterize the anti-inflammatory properties of porcine decellularized nerve matrix hydrogel and their underlying molecular mechanisms.Using peripheral nerve injury model rats treated with porcine decellularized nerve matrix hydrogel,we evaluated structural and functional recovery,macrophage phenotype alteration,specific cytokine expression,and changes in related signaling molecules in vivo.Similar parameters were evaluated in vitro using monocyte/macrophage cell lines stimulated with lipopolysaccharide and cultured on porcine decellularized nerve matrix hydrogel-coated plates in complete medium.These comprehensive analyses revealed that porcine decellularized nerve matrix hydrogel attenuated the activation of excessive inflammation at the early stage of peripheral nerve injury and increased the proportion of the M2 subtype in monocytes/macrophages.Additionally,porcine decellularized nerve matrix hydrogel negatively regulated the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB axis both in vivo and in vitro.Our findings suggest that the efficacious anti-inflammatory properties of porcine decellularized nerve matrix hydrogel induce M2 macrophage polarization via suppression of the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway,providing new insights into the therapeutic mechanism of porcine decellularized nerve matrix hydrogel in peripheral nerve injury.展开更多
Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protei...Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protein 4(HE4),a key diagnostic biomarker for ovarian cancer,is involved in fibrotic processes in several non-malignant diseases.Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis,this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC.Methods:A total of 126 patients with gynecological conditions were included and divided into normal,benign,and EOC groups.Tissue stiffness was quantitatively measured and analyzed for its correlation with clinicopathological features.We further investigated the correlation between tumor stiffness and the expression levels of HE4 and fibroblast activation markers(α-smooth muscle actin(α-SMA)and fibroblast activation protein(FAP))in tumor tissues from 22 HGSOC patients.In vitro,primary fibroblasts were treated with recombinant HE4(rHE4)or conditioned media from HE4-knockdown ovarian cancer cells to assess fibroblasts activation and matrix contractility(Collagen gel contraction assays).In vivo,a subcutaneous xenograft model using HE4-knockdown cells was established to evaluate the effects of HE4 suppression on tumor growth and extensive extracellular matrix(ECM)remodeling.Results:Ovarian cancer tissues showed significantly increased stiffness compared to benign/normal groups,showing positive correlation with serum HE4 levels.High-stiffness HGSOC tumors exhibited upregulated expression of HE4,α-SMA,FAP,and collagen I.rHE4 stimulated fibroblast activation and enhanced matrix contractility,whereas HE4 knockdown in cancer cells abrogated these pro-fibrotic effects.In vivo,HE4-silenced xenografts displayed restricted tumor growth accompanied by reduced stromal expression ofα-SMA,FAP,and collagen I.Conclusion:Our findings suggest that HE4 may facilitate ECM remodeling in HGSOC through promoting fibroblast activation and increasing collagen deposition.展开更多
This paper presents a novel design method for discrete-time repetitive control systems （RCS） based on two-dimensional （2D） discrete-time model. Firstly, the 2D model of an RCS is established by considering both th...This paper presents a novel design method for discrete-time repetitive control systems （RCS） based on two-dimensional （2D） discrete-time model. Firstly, the 2D model of an RCS is established by considering both the control action and the learning action in RCS. Then, through constructing a 2D state feedback controller, the design problem of the RCS is converted to the design problem of a 2D system. Then, using 2D system theory and linear matrix inequality （LMI） method, stability criterion is derived for the system without and with uncertainties, respectively. Parameters of the system can be determined by solving the LMI of the stability criterion. Finally, numerical simulations validate the effectiveness of the proposed method.展开更多
Some theorems of compactly supported non-tensor product form two-dimension Daubechies wavelet were analysed carefully. Compactly supported non-tensor product form two-dimension wavelet was constructed, then non-tensor...Some theorems of compactly supported non-tensor product form two-dimension Daubechies wavelet were analysed carefully. Compactly supported non-tensor product form two-dimension wavelet was constructed, then non-tensor product form two dimension wavelet finite element was used to solve the deflection problem of elastic thin plate. The error order was researched. A numerical example was given at last.展开更多
The adaptive mesh refinement （AMR） method is applied in the 2-D Euler multi-component elasticplastic hydrodynamics code （MEPH2Y）. It is applied on detonation. Firstly, the AMR method is described, including a cons...The adaptive mesh refinement （AMR） method is applied in the 2-D Euler multi-component elasticplastic hydrodynamics code （MEPH2Y）. It is applied on detonation. Firstly, the AMR method is described, including a conservative spatial interpolation, the time integration methodology with the adapitve time increment and an adaptive computational region method. The advantage of AMR technique is exhibited by numerical examples, including the 1-D C-J detonation and the 2-D implosion ignited from a single point. Results show that AMR can promote the computational efficiency, keeping the accuracy in interesting regions.展开更多
The present paper is concerned with the investigation of disturbances in＇a homogeneous, isotropic elastic medium with generalized thermoelastic diffusion, when a moving source is acting along one of the co-ordinate a...The present paper is concerned with the investigation of disturbances in＇a homogeneous, isotropic elastic medium with generalized thermoelastic diffusion, when a moving source is acting along one of the co-ordinate axis on the boundary of the medium. Eigen value approach is applied to study the disturbance in Laplace-Fourier transform domain for a two dimensional problem. The analytical expressions for displacement components, stresses, temperature field, concentration and chemical potential are obtained in the physical domain by using a numerical technique for the inversion of Laplace transform based on Fourier expansion techniques. These expressions are calculated numerically for a copper like material and depicted graphically. As special cases, the results in generalized thermoelastic and elastic media are obtained. Effect of presence of diffusion is analyzed theoretically and numerically.展开更多
Structural alterations in fibroelastic compone nts of the penile corpus caver no usum(CC)may impair its compliance,resulting in venous leakage and erectile dysfunction(ED).Our study evaluated the effectiveness of noni...Structural alterations in fibroelastic compone nts of the penile corpus caver no usum(CC)may impair its compliance,resulting in venous leakage and erectile dysfunction(ED).Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography(2-D SWE)in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED.A total of 12 New Zealand white rabbits were randomly divided into two groups.Six were fed a high-cholesterol diet containing 2%cholesterol and 8.5%lard for 10 weeks and the other six were fed normal diet as controls.We measured the shear-wave elastic quantitative(SWQ)value of penile CC by 2-D SWE.Erectile function was inv estigated by intracavernous injecti on of pa pa ver i ne,and immunohistochemical(IHC)stain inga nd the wester n blot analysis to determine the penile CC lesions.After 10 weeks,the SWQ values obtained from penile CC were remarkably higher in the high-cholesterol-fed compared with the control group,and the AICP(ICP plateau minus ICP baseline)/MAP(ICP:intracavernous pressure,MAP:mean arterial pressure)was markedly decreased.The IHC staining and western blot revealed extracellular matrix(ECM)accumulation in penile cavernous tissues,and the smooth muscle cell(SMC)phenotypic transition was affected,as indicated by reduced alpha-smooth muscle actin and calponinexpression and increased phospho-myosin light chain?。(p-MLC20)/MLC20 and osteopontin expression.Hyperlipidemia resulted in ECM accumulation accompanied with SMC phenotypic transition in penile CC and impaired the erectile function eventually.These might,in turn,lead to variations in the SWQ values.It suggests that 2-D SWE may be a novel,noninvasive and effective approach that distinguishes penile CC lesions secondary to hyperlipidemia from normal.展开更多
This paper is concerned with further relaxations of the stability analysis of nonlinear Roesser-type two-dimensional （2D） systems in the Takagi-Sugeno fuzzy form. To achieve the goal, a novel slack matrix variable t...This paper is concerned with further relaxations of the stability analysis of nonlinear Roesser-type two-dimensional （2D） systems in the Takagi-Sugeno fuzzy form. To achieve the goal, a novel slack matrix variable technique, which is homogenous polynomially parameter-dependent on the normalized fuzzy weighting functions with arbitrary degree, is developed and the algebraic properties of the normalized fuzzy weighting functions are collected into a set of augmented matrices. Consequently, more information about the normalized fuzzy weighting functions is involved and the relaxation quality of the stability analysis is significantly improved. Moreover, the obtained result is formulated in the form of linear matrix inequalities, which can be easily solved via standard numerical software. Finally, a numerical example is provided to demonstrate the effectiveness of the proposed result.展开更多
An analytical solution of the guided wave propagation in a multilayered twodimensional decagonal quasicrystal plate with imperfect interfaces is derived.According to the elastodynamic equations of quasicrystals(QCs),t...An analytical solution of the guided wave propagation in a multilayered twodimensional decagonal quasicrystal plate with imperfect interfaces is derived.According to the elastodynamic equations of quasicrystals(QCs),the wave propagating problem in the plate is converted into a linear control system by employing the state-vector approach,from which the general solutions of the extended displacements and stresses can be obtained,These solutions along the thickness direction are utilized to derive the propagator matrix which connects the physical variables on the lower and upper interfaces of each layer.The special spring model,which describes the discontinuity of the physical quantities across the interface,is introduced into the propagator relationship of the multilayered structure.The total propagator matrix can be used to propagate the solutions in each interface and each layer about the multilayered plate.In addition,the traction-free boundary condition on the top and bottom surfaces of the laminate is considered to obtain the dispersion equation of wave propagation,Finally,typical numerical examples are presented to illustrate the marked influences of stacking sequence and interface coeficients on the dispersion curves and displacement mode shapes of the QC laminates.展开更多
This paper investigates the numerical solution of two-dimensional nonlinear stochastic Itô-Volterra integral equations based on block pulse functions. The nonlinear stochastic integral equation is transformed...This paper investigates the numerical solution of two-dimensional nonlinear stochastic Itô-Volterra integral equations based on block pulse functions. The nonlinear stochastic integral equation is transformed into a set of algebraic equations by operational matrix of block pulse functions. Then, we give error analysis and prove that the rate of convergence of this method is efficient. Lastly, a numerical example is given to confirm the method.展开更多
文摘Flexible X-ray detectors have garnered considerable attention owing to their extensive applications in three-dimensional (3D) image reconstruction, disease diagnosis and nondestructive testing^([1-3]). Conventional X-ray detectors typically employ active-matrix backplanes fabricated on rigid glass substrates, which integrate switching transistors and photodetectors^([4, 5]).
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61006059 and 61774012)Beijing Municipal Natural Science Foundation,China(Grant No.4143059)+3 种基金Beijing Municipal Education Committee,China(Grant No.KM201710005027)Postdoctoral Science Foundation of Beijing,China(Grant No.2015ZZ-11)China Postdoctoral Science Foundation(Grant No.2015M580951)Scientific Research Foundation Project of Beijing Future Chip Technology Innovation Center,China(Grant No.KYJJ2016008)
文摘Based on the thermal network of the two-dimensional heterojunction bipolar transistors(HBTs) array, the thermal resistance matrix is presented, including the self-heating thermal resistance and thermal coupling resistance to describe the self-heating and thermal coupling effects, respectively.For HBT cells along the emitter length direction, the thermal coupling resistance is far smaller than the self-heating thermal resistance, and the peak junction temperature is mainly determined by the self-heating thermal resistance.However, the thermal coupling resistance is in the same order with the self-heating thermal resistance for HBT cells along the emitter width direction.Furthermore, the dependence of the thermal resistance matrix on cell spacing along the emitter length direction and cell spacing along the emitter width direction is also investigated, respectively.It is shown that the moderate increase of cell spacings along the emitter length direction and the emitter width direction could effectively lower the self-heating thermal resistance and thermal coupling resistance,and hence the peak junction temperature is decreased, which sheds light on adopting a two-dimensional non-uniform cell spacing layout to improve the uneven temperature distribution.By taking a 2 × 6 HBTs array for example, a twodimensional non-uniform cell spacing layout is designed, which can effectively lower the peak junction temperature and reduce the non-uniformity of the dissipated power.For the HBTs array with optimized layout, the high power-handling capability and thermal dissipation capability are kept when the bias voltage increases.
基金National Natural Science Foundation of China under Grant No.61973037China Postdoctoral Science Foundation under Grant No.2022M720419。
文摘Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this paper.First,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing process.Second,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR model.Finally,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation type.Theoretical analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR method.The recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR.
基金supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20070126002)the National Natural Science Foundation of China (No. 10962004)
文摘This paper studies the eigenfunction expansion method to solve the two dimensional （2D） elasticity problems based on the stress formulation. The fundamental system of partial differential equations of the 2D problems is rewritten as an upper tri angular differential system based on the known results, and then the associated upper triangular operator matrix matrix is obtained. By further research, the two simpler com plete orthogonal systems of eigenfunctions in some space are obtained, which belong to the two block operators arising in the operator matrix. Then, a more simple and conve nient general solution to the 2D problem is given by the eigenfunction expansion method. Furthermore, the boundary conditions for the 2D problem, which can be solved by this method, are indicated. Finally, the validity of the obtained results is verified by a specific example.
基金Supported in part by Natural Science Foundation of Guangxi(2023GXNSFAA026246)in part by the Central Government's Guide to Local Science and Technology Development Fund(GuikeZY23055044)in part by the National Natural Science Foundation of China(62363003)。
文摘In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.
基金supported by the National Natural Science Foundation of China(62376106)The Science and Technology Development Plan of Jilin Province(20250102212JC).
文摘Driven by advancements in mobile internet technology,images have become a crucial data medium.Ensuring the security of image information during transmission has thus emerged as an urgent challenge.This study proposes a novel image encryption algorithm specifically designed for grayscale image security.This research introduces a new Cantor diagonal matrix permutation method.The proposed permutation method uses row and column index sequences to control the Cantor diagonal matrix,where the row and column index sequences are generated by a spatiotemporal chaotic system named coupled map lattice(CML).The high initial value sensitivity of the CML system makes the permutation method highly sensitive and secure.Additionally,leveraging fractal theory,this study introduces a chaotic fractal matrix and applies this matrix in the diffusion process.This chaotic fractal matrix exhibits selfsimilarity and irregularity.Using the Cantor diagonal matrix and chaotic fractal matrix,this paper introduces a fast image encryption algorithm involving two diffusion steps and one permutation step.Moreover,the algorithm achieves robust security with only a single encryption round,ensuring high operational efficiency.Experimental results show that the proposed algorithm features an expansive key space,robust security,high sensitivity,high efficiency,and superior statistical properties for the ciphered images.Thus,the proposed algorithm not only provides a practical solution for secure image transmission but also bridges fractal theory with image encryption techniques,thereby opening new research avenues in chaotic cryptography and advancing the development of information security technology.
文摘We read with the great interest the study by Ababneh et al in which inducedmesenchymal stem cell-derived exosomes were shown to exhibit a stronger andmore sustained anti-proliferative effect by inducing a senescence-like state withoutapoptosis.The results obtained by the authors highlight the features of theeffects of senescent drift induction in surrounding tissues.In the light of thesefindings,the role of the properties of extracellular matrix and cellular glycocalyxin responses of human tumors to therapy remain uninvestigated.These extracellularbarriers appear to be significant obstacles to effective cancer therapy,especiallyin relation to the use of unique properties of tumor microenvironment forthe immunotherapy-resistant cancer treatment.
基金supported by the Shenzhen Hong Kong Joint Funding Project,No.SGDX20230116093645007(to LY)the Shenzhen Science and Technology Innovation Committee International Cooperation Project,No.GJHZ20200731095608025(to LY)+7 种基金Shenzhen Development and Reform Commission’s Intelligent Diagnosis,Treatment and Prevention of Adolescent Spinal Health Public Service Platform,No.S2002Q84500835(to LY)Shenzhen Medical Research Fund,No.B2303005(to LY)Team-based Medical Science Research Program,No.2024YZZ02(to LY)Zhejiang Provincial Natural Science Foundation of China,No.LWQ20H170001(to RL)Basic Research Project of Shenzhen Science and Technology from Shenzhen Science and Technology Innovation Commission,No.JCYJ20210324103010029(to BY)Shenzhen Second People’s Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction Project,Nos.2023yjlcyj029(to BY),2023yjlcyj021(to LL)Guangdong Basic and Applied Basic Research Foundation,No.2022A1515110679(to LL)China Postdoctoral Science Foundation,No.2022M722203(to GL).
文摘Peripheral nerve injury causes severe neuroinflammation and has become a global medical challenge.Previous research has demonstrated that porcine decellularized nerve matrix hydrogel exhibits excellent biological properties and tissue specificity,highlighting its potential as a biomedical material for the repair of severe peripheral nerve injury;however,its role in modulating neuroinflammation post-peripheral nerve injury remains unknown.Here,we aimed to characterize the anti-inflammatory properties of porcine decellularized nerve matrix hydrogel and their underlying molecular mechanisms.Using peripheral nerve injury model rats treated with porcine decellularized nerve matrix hydrogel,we evaluated structural and functional recovery,macrophage phenotype alteration,specific cytokine expression,and changes in related signaling molecules in vivo.Similar parameters were evaluated in vitro using monocyte/macrophage cell lines stimulated with lipopolysaccharide and cultured on porcine decellularized nerve matrix hydrogel-coated plates in complete medium.These comprehensive analyses revealed that porcine decellularized nerve matrix hydrogel attenuated the activation of excessive inflammation at the early stage of peripheral nerve injury and increased the proportion of the M2 subtype in monocytes/macrophages.Additionally,porcine decellularized nerve matrix hydrogel negatively regulated the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB axis both in vivo and in vitro.Our findings suggest that the efficacious anti-inflammatory properties of porcine decellularized nerve matrix hydrogel induce M2 macrophage polarization via suppression of the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway,providing new insights into the therapeutic mechanism of porcine decellularized nerve matrix hydrogel in peripheral nerve injury.
文摘Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protein 4(HE4),a key diagnostic biomarker for ovarian cancer,is involved in fibrotic processes in several non-malignant diseases.Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis,this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC.Methods:A total of 126 patients with gynecological conditions were included and divided into normal,benign,and EOC groups.Tissue stiffness was quantitatively measured and analyzed for its correlation with clinicopathological features.We further investigated the correlation between tumor stiffness and the expression levels of HE4 and fibroblast activation markers(α-smooth muscle actin(α-SMA)and fibroblast activation protein(FAP))in tumor tissues from 22 HGSOC patients.In vitro,primary fibroblasts were treated with recombinant HE4(rHE4)or conditioned media from HE4-knockdown ovarian cancer cells to assess fibroblasts activation and matrix contractility(Collagen gel contraction assays).In vivo,a subcutaneous xenograft model using HE4-knockdown cells was established to evaluate the effects of HE4 suppression on tumor growth and extensive extracellular matrix(ECM)remodeling.Results:Ovarian cancer tissues showed significantly increased stiffness compared to benign/normal groups,showing positive correlation with serum HE4 levels.High-stiffness HGSOC tumors exhibited upregulated expression of HE4,α-SMA,FAP,and collagen I.rHE4 stimulated fibroblast activation and enhanced matrix contractility,whereas HE4 knockdown in cancer cells abrogated these pro-fibrotic effects.In vivo,HE4-silenced xenografts displayed restricted tumor growth accompanied by reduced stromal expression ofα-SMA,FAP,and collagen I.Conclusion:Our findings suggest that HE4 may facilitate ECM remodeling in HGSOC through promoting fibroblast activation and increasing collagen deposition.
基金supported by National Natural Science Foundation of China (Nos. 60974045 and 60674016)the Research Foundation of Education Bureau of Hunan Province, China (No. 08C090)
文摘This paper presents a novel design method for discrete-time repetitive control systems （RCS） based on two-dimensional （2D） discrete-time model. Firstly, the 2D model of an RCS is established by considering both the control action and the learning action in RCS. Then, through constructing a 2D state feedback controller, the design problem of the RCS is converted to the design problem of a 2D system. Then, using 2D system theory and linear matrix inequality （LMI） method, stability criterion is derived for the system without and with uncertainties, respectively. Parameters of the system can be determined by solving the LMI of the stability criterion. Finally, numerical simulations validate the effectiveness of the proposed method.
文摘Some theorems of compactly supported non-tensor product form two-dimension Daubechies wavelet were analysed carefully. Compactly supported non-tensor product form two-dimension wavelet was constructed, then non-tensor product form two dimension wavelet finite element was used to solve the deflection problem of elastic thin plate. The error order was researched. A numerical example was given at last.
基金Sponsored by the National Natural Science Foundation of China(10676120)Laboratory of Computational Physics Foundation(9140C690101070C69)
文摘The adaptive mesh refinement （AMR） method is applied in the 2-D Euler multi-component elasticplastic hydrodynamics code （MEPH2Y）. It is applied on detonation. Firstly, the AMR method is described, including a conservative spatial interpolation, the time integration methodology with the adapitve time increment and an adaptive computational region method. The advantage of AMR technique is exhibited by numerical examples, including the 1-D C-J detonation and the 2-D implosion ignited from a single point. Results show that AMR can promote the computational efficiency, keeping the accuracy in interesting regions.
文摘The present paper is concerned with the investigation of disturbances in＇a homogeneous, isotropic elastic medium with generalized thermoelastic diffusion, when a moving source is acting along one of the co-ordinate axis on the boundary of the medium. Eigen value approach is applied to study the disturbance in Laplace-Fourier transform domain for a two dimensional problem. The analytical expressions for displacement components, stresses, temperature field, concentration and chemical potential are obtained in the physical domain by using a numerical technique for the inversion of Laplace transform based on Fourier expansion techniques. These expressions are calculated numerically for a copper like material and depicted graphically. As special cases, the results in generalized thermoelastic and elastic media are obtained. Effect of presence of diffusion is analyzed theoretically and numerically.
基金the National Natural Science Foundation of China(Grant No.81401195)Nature Science Foundation of Shanghai(Grant No.17ZR1422400).
文摘Structural alterations in fibroelastic compone nts of the penile corpus caver no usum(CC)may impair its compliance,resulting in venous leakage and erectile dysfunction(ED).Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography(2-D SWE)in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED.A total of 12 New Zealand white rabbits were randomly divided into two groups.Six were fed a high-cholesterol diet containing 2%cholesterol and 8.5%lard for 10 weeks and the other six were fed normal diet as controls.We measured the shear-wave elastic quantitative(SWQ)value of penile CC by 2-D SWE.Erectile function was inv estigated by intracavernous injecti on of pa pa ver i ne,and immunohistochemical(IHC)stain inga nd the wester n blot analysis to determine the penile CC lesions.After 10 weeks,the SWQ values obtained from penile CC were remarkably higher in the high-cholesterol-fed compared with the control group,and the AICP(ICP plateau minus ICP baseline)/MAP(ICP:intracavernous pressure,MAP:mean arterial pressure)was markedly decreased.The IHC staining and western blot revealed extracellular matrix(ECM)accumulation in penile cavernous tissues,and the smooth muscle cell(SMC)phenotypic transition was affected,as indicated by reduced alpha-smooth muscle actin and calponinexpression and increased phospho-myosin light chain?。(p-MLC20)/MLC20 and osteopontin expression.Hyperlipidemia resulted in ECM accumulation accompanied with SMC phenotypic transition in penile CC and impaired the erectile function eventually.These might,in turn,lead to variations in the SWQ values.It suggests that 2-D SWE may be a novel,noninvasive and effective approach that distinguishes penile CC lesions secondary to hyperlipidemia from normal.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61203057 and 51305066)
文摘This paper is concerned with further relaxations of the stability analysis of nonlinear Roesser-type two-dimensional （2D） systems in the Takagi-Sugeno fuzzy form. To achieve the goal, a novel slack matrix variable technique, which is homogenous polynomially parameter-dependent on the normalized fuzzy weighting functions with arbitrary degree, is developed and the algebraic properties of the normalized fuzzy weighting functions are collected into a set of augmented matrices. Consequently, more information about the normalized fuzzy weighting functions is involved and the relaxation quality of the stability analysis is significantly improved. Moreover, the obtained result is formulated in the form of linear matrix inequalities, which can be easily solved via standard numerical software. Finally, a numerical example is provided to demonstrate the effectiveness of the proposed result.
基金supported by the National Natural Science Foundation of China(Grant Nos.11972365,12102458,and 11972354)China Agricultural University Education Foundation(No.1101-2412001).
文摘An analytical solution of the guided wave propagation in a multilayered twodimensional decagonal quasicrystal plate with imperfect interfaces is derived.According to the elastodynamic equations of quasicrystals(QCs),the wave propagating problem in the plate is converted into a linear control system by employing the state-vector approach,from which the general solutions of the extended displacements and stresses can be obtained,These solutions along the thickness direction are utilized to derive the propagator matrix which connects the physical variables on the lower and upper interfaces of each layer.The special spring model,which describes the discontinuity of the physical quantities across the interface,is introduced into the propagator relationship of the multilayered structure.The total propagator matrix can be used to propagate the solutions in each interface and each layer about the multilayered plate.In addition,the traction-free boundary condition on the top and bottom surfaces of the laminate is considered to obtain the dispersion equation of wave propagation,Finally,typical numerical examples are presented to illustrate the marked influences of stacking sequence and interface coeficients on the dispersion curves and displacement mode shapes of the QC laminates.
基金NSF Grants 11471105 of China, NSF Grants 2016CFB526 of Hubei Province, Innovation Team of the Educational Department of Hubei Province T201412, and Innovation Items of Hubei Normal University 2018032 and 2018105
文摘This paper investigates the numerical solution of two-dimensional nonlinear stochastic Itô-Volterra integral equations based on block pulse functions. The nonlinear stochastic integral equation is transformed into a set of algebraic equations by operational matrix of block pulse functions. Then, we give error analysis and prove that the rate of convergence of this method is efficient. Lastly, a numerical example is given to confirm the method.
