A substitution box(S-Box)is a crucial component of contemporary cryptosystems that provide data protection in block ciphers.At the moment,chaotic maps are being created and extensively used to generate these SBoxes as...A substitution box(S-Box)is a crucial component of contemporary cryptosystems that provide data protection in block ciphers.At the moment,chaotic maps are being created and extensively used to generate these SBoxes as a chaotic map assists in providing disorder and resistance to combat cryptanalytical attempts.In this paper,the construction of a dynamic S-Box using a cipher key is proposed using a novel chaotic map and an innovative tweaking approach.The projected chaotic map and the proposed tweak approach are presented for the first time and the use of parameters in their workingmakes both of these dynamic in nature.The tweak approach employs cubic polynomials while permuting the values of an initial S-Box to enhance its cryptographic fort.Values of the parameters are provided using the cipher key and a small variation in values of these parameters results in a completely different unique S-Box.Comparative analysis and exploration confirmed that the projected chaoticmap exhibits a significant amount of chaotic complexity.The security assessment in terms of bijectivity,nonlinearity,bits independence,strict avalanche,linear approximation probability,and differential probability criteria are utilized to critically investigate the effectiveness of the proposed S-Box against several assaults.The proposed S-Box’s cryptographic performance is comparable to those of recently projected S-Boxes for its adaption in real-world security applications.The comparative scrutiny pacifies the genuine potential of the proposed S-Box in terms of its applicability for data security.展开更多
目的:探讨腺病毒介导的TWEAK基因对骨髓间充质干细胞(Bone M esenchym al Stem Cells,BMSCs)细胞的影响。方法:构建含有TWEAK基因的腺病毒载体Ad5CMV-TWEAK和含绿色荧光蛋白的对照腺病毒载体Ad5CMV-EGFP;利用全骨髓贴壁法分离纯BMSCs,...目的:探讨腺病毒介导的TWEAK基因对骨髓间充质干细胞(Bone M esenchym al Stem Cells,BMSCs)细胞的影响。方法:构建含有TWEAK基因的腺病毒载体Ad5CMV-TWEAK和含绿色荧光蛋白的对照腺病毒载体Ad5CMV-EGFP;利用全骨髓贴壁法分离纯BMSCs,通过转染Ad5CMV-EGFP确定病毒对BMSCs的转染效率;以未经转染的BMSCs细胞为空白对照组,以转染Ad5CMV-EGFP为实验对照组,以转染Ad5CMV-TWEAK为实验组,通过计数细胞和测定细胞碱性磷酸酶含量观察转染TWEAK对BMSCs增殖和骨形成能力的影响。结果:Ad5CMT-EGFP对大鼠BMSCs的感染率在300partic les/cell时可达到85%;感染后72小时组实验组与空白对照组差异有统计学分析意义(P<0.05),实验对照组与空白对照组差异无统计学分析意义;感染后15 d内各时间点3组间碱性磷酸酶的分泌量经t检验,差异无统计学意义。结论:腺病毒介导的TWEAK基因对于BMSCs具有增殖作用,但并不通过碱性磷酸酶影响BMSCs成骨能力,其在骨形成中的作用需要进一步探讨。展开更多
文摘A substitution box(S-Box)is a crucial component of contemporary cryptosystems that provide data protection in block ciphers.At the moment,chaotic maps are being created and extensively used to generate these SBoxes as a chaotic map assists in providing disorder and resistance to combat cryptanalytical attempts.In this paper,the construction of a dynamic S-Box using a cipher key is proposed using a novel chaotic map and an innovative tweaking approach.The projected chaotic map and the proposed tweak approach are presented for the first time and the use of parameters in their workingmakes both of these dynamic in nature.The tweak approach employs cubic polynomials while permuting the values of an initial S-Box to enhance its cryptographic fort.Values of the parameters are provided using the cipher key and a small variation in values of these parameters results in a completely different unique S-Box.Comparative analysis and exploration confirmed that the projected chaoticmap exhibits a significant amount of chaotic complexity.The security assessment in terms of bijectivity,nonlinearity,bits independence,strict avalanche,linear approximation probability,and differential probability criteria are utilized to critically investigate the effectiveness of the proposed S-Box against several assaults.The proposed S-Box’s cryptographic performance is comparable to those of recently projected S-Boxes for its adaption in real-world security applications.The comparative scrutiny pacifies the genuine potential of the proposed S-Box in terms of its applicability for data security.
文摘目的:探讨腺病毒介导的TWEAK基因对骨髓间充质干细胞(Bone M esenchym al Stem Cells,BMSCs)细胞的影响。方法:构建含有TWEAK基因的腺病毒载体Ad5CMV-TWEAK和含绿色荧光蛋白的对照腺病毒载体Ad5CMV-EGFP;利用全骨髓贴壁法分离纯BMSCs,通过转染Ad5CMV-EGFP确定病毒对BMSCs的转染效率;以未经转染的BMSCs细胞为空白对照组,以转染Ad5CMV-EGFP为实验对照组,以转染Ad5CMV-TWEAK为实验组,通过计数细胞和测定细胞碱性磷酸酶含量观察转染TWEAK对BMSCs增殖和骨形成能力的影响。结果:Ad5CMT-EGFP对大鼠BMSCs的感染率在300partic les/cell时可达到85%;感染后72小时组实验组与空白对照组差异有统计学分析意义(P<0.05),实验对照组与空白对照组差异无统计学分析意义;感染后15 d内各时间点3组间碱性磷酸酶的分泌量经t检验,差异无统计学意义。结论:腺病毒介导的TWEAK基因对于BMSCs具有增殖作用,但并不通过碱性磷酸酶影响BMSCs成骨能力,其在骨形成中的作用需要进一步探讨。
