Inhibition effects, control probabilities and pathology tissue changes of mouse transplanted tumors S180 after irradiation with 50 MeVu 12C6+ ions are reported. Doses of single irradiation were 0.5, 1, 2, 5, 10, 20, 4...Inhibition effects, control probabilities and pathology tissue changes of mouse transplanted tumors S180 after irradiation with 50 MeVu 12C6+ ions are reported. Doses of single irradiation were 0.5, 1, 2, 5, 10, 20, 40 Gy, respectivelyl at a dose rate of 3 Gy/min. Observing time was 24 days. The results show that each group had significant inhibition action on S180 tumors and all inhibitory probabilities were more than 90%; the initial time of inducing tumor inhibition effects were within one week in high dose groups （20, 40 Gy）, and after two weeks in medium dose groups （5, 10 Gy） and low dose groups （0.5, 1, 2 Gy）; also, inhibitory effects in high dose groups were obviously greater than other groups （p <0.05）; tumor control probabilities were different in each group) those in high dose groups （20, 40 Gy） were higher and TCD50 （50% tumor control dose） was 20Gy; the results for curing tumors are different in different doses; pathology inspection presented here were tumor tissue necrosis and degeneration in each dose group and they depended on doses.展开更多
目的:探讨经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)联合辅助动脉化疗对膀胱癌患者术后控尿、性能力及肿瘤控制效果的影响。方法:选取我院2013年5月至2015年5月收治的92例拟行TURBT术治疗的膀胱癌患者为...目的:探讨经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)联合辅助动脉化疗对膀胱癌患者术后控尿、性能力及肿瘤控制效果的影响。方法:选取我院2013年5月至2015年5月收治的92例拟行TURBT术治疗的膀胱癌患者为研究对象,随机分为观察组(46例)和对照组(46例),对照组行TURBT术+术后灌注化疗,观察组行术前动脉化疗+TURBT术+术后灌注化疗,比较两组患者围术期情况和术后不同时间控尿率、勃起功能国际问卷(IIEF-5)评分、复发率、总体生存率(OS)生命质量综合评定问卷(GQOLI-74)评分。结果:观察组术中出血量、手术时间、尿管留置时间和住院天数均明显少于对照组(P<0.05);两组间术后3个月IIEF-5评分无显著差异(P>0.05),观察组术后其他时间点IIEF-5评分和各时间点控尿率均明显高于对照组(P<0.05);两组术后6、12、24个月死亡率比较,无显著差异(P>0.05);观察组术后6、12、24个月躯体功能、社会功能、物质生活、心理功能评分均显著高于对照组(P<0.05)。结论:TURBT术联合辅助动脉化疗可有效控制膀胱癌,提高躯体、社会、心理功能等相关生命质量。展开更多
基金President Special Foundation of the Chinese Academy of Sciences
文摘Inhibition effects, control probabilities and pathology tissue changes of mouse transplanted tumors S180 after irradiation with 50 MeVu 12C6+ ions are reported. Doses of single irradiation were 0.5, 1, 2, 5, 10, 20, 40 Gy, respectivelyl at a dose rate of 3 Gy/min. Observing time was 24 days. The results show that each group had significant inhibition action on S180 tumors and all inhibitory probabilities were more than 90%; the initial time of inducing tumor inhibition effects were within one week in high dose groups （20, 40 Gy）, and after two weeks in medium dose groups （5, 10 Gy） and low dose groups （0.5, 1, 2 Gy）; also, inhibitory effects in high dose groups were obviously greater than other groups （p <0.05）; tumor control probabilities were different in each group) those in high dose groups （20, 40 Gy） were higher and TCD50 （50% tumor control dose） was 20Gy; the results for curing tumors are different in different doses; pathology inspection presented here were tumor tissue necrosis and degeneration in each dose group and they depended on doses.
文摘目的:探讨经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)联合辅助动脉化疗对膀胱癌患者术后控尿、性能力及肿瘤控制效果的影响。方法:选取我院2013年5月至2015年5月收治的92例拟行TURBT术治疗的膀胱癌患者为研究对象,随机分为观察组(46例)和对照组(46例),对照组行TURBT术+术后灌注化疗,观察组行术前动脉化疗+TURBT术+术后灌注化疗,比较两组患者围术期情况和术后不同时间控尿率、勃起功能国际问卷(IIEF-5)评分、复发率、总体生存率(OS)生命质量综合评定问卷(GQOLI-74)评分。结果:观察组术中出血量、手术时间、尿管留置时间和住院天数均明显少于对照组(P<0.05);两组间术后3个月IIEF-5评分无显著差异(P>0.05),观察组术后其他时间点IIEF-5评分和各时间点控尿率均明显高于对照组(P<0.05);两组术后6、12、24个月死亡率比较,无显著差异(P>0.05);观察组术后6、12、24个月躯体功能、社会功能、物质生活、心理功能评分均显著高于对照组(P<0.05)。结论:TURBT术联合辅助动脉化疗可有效控制膀胱癌,提高躯体、社会、心理功能等相关生命质量。
