The inter-related pathological cascades following a traumatic spinal cord injury(tSCI)disrupt multiple cell types and physiological processes.Subsequently,motor and sensory functions are disrupted by breakdowns in cel...The inter-related pathological cascades following a traumatic spinal cord injury(tSCI)disrupt multiple cell types and physiological processes.Subsequently,motor and sensory functions are disrupted by breakdowns in cellular interactions and circuitry.Therapeutic interventions seek to modify some aspects of the injury course to enable the re-establishment of functional circuitry.Interventions often target one cell type(e.g.,promoting neuroprotection or neural regeneration)or one process(e.g.,modulating inflammation,affecting astrocytic,microglial,or macrophage responses.)Many axons in the spinal cord are myelinated,and after injury oligodendrocyte death causes demyelination.Promoting remyelination of spared or new axons to re-establish conduction seems a logical choice as a therapeutic target.展开更多
[Objectives] To systemically review the efficacy and safety of Panax Notoginseng Saponins( PNS) in the treatment of traumatic spinal-cord injury( TSCI) in rat models. [Methods] Randomized controlled trials( RCT) about...[Objectives] To systemically review the efficacy and safety of Panax Notoginseng Saponins( PNS) in the treatment of traumatic spinal-cord injury( TSCI) in rat models. [Methods] Randomized controlled trials( RCT) about the effects of PNS for TSCI in rats were searched in Pub Med,EMbase,The Cochrane Library,CBM,CNKI,Wan Fang Data from inception to November 2016. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed the risk of bias of included studies.Then Meta-analysis was performed using Rev Man 5. 3 software. [Results] A total of 6 RCTs involving 264 rats were included. The results of Meta-analysis showed that: compared with the control group,the Basso,Beattie and Bresnahan( BBB) scores in the PNS group were superior in 7 days( SMD = 1. 81,95% CI( 1. 18,2. 43),P < 0. 00001),14 days( SMD = 1. 92,95% CI( 1. 51,2. 33),P < 0. 00001),21 days( SMD =2. 33,95% CI( 0. 98,3. 68),P <0. 0007) and 28 days( SMD =2. 72,95% CI( 1. 78,3. 67),P <0. 00001) after surgery. The results of Meta-analysis showed that: compared with the control group,ramp test in the PNS group were superior in 7 days [SMD = 1. 55,95% CI( 0. 78,2. 31),P <0. 0001]and 14 days[SMD =1. 83,95% CI( 1. 46,2. 20),P < 0. 00001]. [Conclusions] Current evidence indicates that PNS can promote the recovery of motor function in the rats with TSCI. Due to limited quality of the included studies,the above conclusion should be verified by conducting more large-scale,high quality RCTs.展开更多
基金supported by Grant 3195 from Paralyzed Veterans of America Research Foundation (to BRK)
文摘The inter-related pathological cascades following a traumatic spinal cord injury(tSCI)disrupt multiple cell types and physiological processes.Subsequently,motor and sensory functions are disrupted by breakdowns in cellular interactions and circuitry.Therapeutic interventions seek to modify some aspects of the injury course to enable the re-establishment of functional circuitry.Interventions often target one cell type(e.g.,promoting neuroprotection or neural regeneration)or one process(e.g.,modulating inflammation,affecting astrocytic,microglial,or macrophage responses.)Many axons in the spinal cord are myelinated,and after injury oligodendrocyte death causes demyelination.Promoting remyelination of spared or new axons to re-establish conduction seems a logical choice as a therapeutic target.
文摘[Objectives] To systemically review the efficacy and safety of Panax Notoginseng Saponins( PNS) in the treatment of traumatic spinal-cord injury( TSCI) in rat models. [Methods] Randomized controlled trials( RCT) about the effects of PNS for TSCI in rats were searched in Pub Med,EMbase,The Cochrane Library,CBM,CNKI,Wan Fang Data from inception to November 2016. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed the risk of bias of included studies.Then Meta-analysis was performed using Rev Man 5. 3 software. [Results] A total of 6 RCTs involving 264 rats were included. The results of Meta-analysis showed that: compared with the control group,the Basso,Beattie and Bresnahan( BBB) scores in the PNS group were superior in 7 days( SMD = 1. 81,95% CI( 1. 18,2. 43),P < 0. 00001),14 days( SMD = 1. 92,95% CI( 1. 51,2. 33),P < 0. 00001),21 days( SMD =2. 33,95% CI( 0. 98,3. 68),P <0. 0007) and 28 days( SMD =2. 72,95% CI( 1. 78,3. 67),P <0. 00001) after surgery. The results of Meta-analysis showed that: compared with the control group,ramp test in the PNS group were superior in 7 days [SMD = 1. 55,95% CI( 0. 78,2. 31),P <0. 0001]and 14 days[SMD =1. 83,95% CI( 1. 46,2. 20),P < 0. 00001]. [Conclusions] Current evidence indicates that PNS can promote the recovery of motor function in the rats with TSCI. Due to limited quality of the included studies,the above conclusion should be verified by conducting more large-scale,high quality RCTs.
