BACKGROUND Acanthosis nigricans(AN),Leser–Trélat sign,and tripe palm are all skin diseases.To date,reports of these appearing as a paraneoplastic syndrome in a gastric cancer patient are quite rare.CASE SUMMARY ...BACKGROUND Acanthosis nigricans(AN),Leser–Trélat sign,and tripe palm are all skin diseases.To date,reports of these appearing as a paraneoplastic syndrome in a gastric cancer patient are quite rare.CASE SUMMARY We report the case of a 61-year-old man with darkened skin color in the face and torso with no obvious inducement after 1 year of treatment for Riehl’s melanosis.He had 40 brown maculopapular eruptions on his face and the top of his head with obvious itching.Papillary wart-like hyperkeratosis with dark brown pigmentation was also observed on both sides of the areola.He had papillomalike lesions on the face,around the orbit,and on the neck.His bilateral palms had small,smooth,papillary projections with millet-like appearance.Histopathological examination of the skin showed that the patient was suffering from AN,tripe palms,and Leser–Trélat sign.Gastroscopy showed the patient’s cardia was affected,and pathological biopsy revealed that he had moderate-to-poorly differentiated adenocarcinoma.Computed tomography test results showed that his cardia wall had thickened.Based on these histological and skin characteristics,the patient was diagnosed with gastric cancer with AN,tripe palms,and Leser–Trélat sign.CONCLUSION Researchers should follow up on patients with malignant AN,Leser–Trélat sign,and tripe palms.展开更多
The tripe gene block(TGB)genes of Barley stripe mosaic virus China strain(BSMV-CH)were amplified from cDNA of BSMV-CH RNAβ(GenBank accession No:AY789694)by PCR with special primer pairs,and cloned into pMD18-T vector...The tripe gene block(TGB)genes of Barley stripe mosaic virus China strain(BSMV-CH)were amplified from cDNA of BSMV-CH RNAβ(GenBank accession No:AY789694)by PCR with special primer pairs,and cloned into pMD18-T vector for sequencing.Analysis of the sequences showed that the full length of BSMV-CH TGB1,TGB2 and TGB3 were 1 539,396 and 468 bp,with deduced 512,131 and 155 amino acids,respectively.BSMV-CH TGB1 shared 94.1%-95.4% nucleotide identities and 91.0%-94.5% amino acid identities with that of other BSMV strains,BSMV-CH TGB2 shared 96.5%-97.2% nucleotide identities and 98.5%-99.2% amino acid identities with that of other BSMV strains,and BSMV-CH TGB3 shared 95.7%-96.6% nucleotide identities and 94.2%-96.8% amino acid identities with that of other BSMV strains.Phylogenetic tree based on the amino acid of Hordeiviruses TGB genes showed that BSMV-CH was relatively closed to CV17 in genetic relationship.Therefore,BSMV-CH was deduced to be a recombined strain of CV17 and CV42.展开更多
基金Supported by the Focus on Research and Transformation Projects of Qinghai Province,No.2018-SF-113.
文摘BACKGROUND Acanthosis nigricans(AN),Leser–Trélat sign,and tripe palm are all skin diseases.To date,reports of these appearing as a paraneoplastic syndrome in a gastric cancer patient are quite rare.CASE SUMMARY We report the case of a 61-year-old man with darkened skin color in the face and torso with no obvious inducement after 1 year of treatment for Riehl’s melanosis.He had 40 brown maculopapular eruptions on his face and the top of his head with obvious itching.Papillary wart-like hyperkeratosis with dark brown pigmentation was also observed on both sides of the areola.He had papillomalike lesions on the face,around the orbit,and on the neck.His bilateral palms had small,smooth,papillary projections with millet-like appearance.Histopathological examination of the skin showed that the patient was suffering from AN,tripe palms,and Leser–Trélat sign.Gastroscopy showed the patient’s cardia was affected,and pathological biopsy revealed that he had moderate-to-poorly differentiated adenocarcinoma.Computed tomography test results showed that his cardia wall had thickened.Based on these histological and skin characteristics,the patient was diagnosed with gastric cancer with AN,tripe palms,and Leser–Trélat sign.CONCLUSION Researchers should follow up on patients with malignant AN,Leser–Trélat sign,and tripe palms.
文摘The tripe gene block(TGB)genes of Barley stripe mosaic virus China strain(BSMV-CH)were amplified from cDNA of BSMV-CH RNAβ(GenBank accession No:AY789694)by PCR with special primer pairs,and cloned into pMD18-T vector for sequencing.Analysis of the sequences showed that the full length of BSMV-CH TGB1,TGB2 and TGB3 were 1 539,396 and 468 bp,with deduced 512,131 and 155 amino acids,respectively.BSMV-CH TGB1 shared 94.1%-95.4% nucleotide identities and 91.0%-94.5% amino acid identities with that of other BSMV strains,BSMV-CH TGB2 shared 96.5%-97.2% nucleotide identities and 98.5%-99.2% amino acid identities with that of other BSMV strains,and BSMV-CH TGB3 shared 95.7%-96.6% nucleotide identities and 94.2%-96.8% amino acid identities with that of other BSMV strains.Phylogenetic tree based on the amino acid of Hordeiviruses TGB genes showed that BSMV-CH was relatively closed to CV17 in genetic relationship.Therefore,BSMV-CH was deduced to be a recombined strain of CV17 and CV42.
