Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsist...Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsistent.It remains unclear whether these associations are causal.Methods We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia.Mendelian randomization(MR)analysis based on summary genome-wide association studies(GWASs)was performed.Genetic correlation and Bayesian colocalization analyses were used to provide robust genetic evidence.Results Ten observational studies involving 80,565,688 participants were included in this metaanalysis.IBD was significantly associated with dementia(risk ratio[RR]=1.36,95%CI=1.04-1.78;I2=84.8%)and VD(RR=2.60,95%CI=1.18-5.70;only one study),but not with AD(RR=2.00,95%CI=0.96-4.13;I^(2)=99.8%).MR analyses did not supported significant causal associations of IBD with dementia(dementia:odds ratio[OR]=1.01,95%CI=0.98-1.03;AD:OR=0.98,95%CI=0.95-1.01;VD:OR=1.02,95%CI=0.97-1.07).In addition,genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.Conclusion Our study did not provide genetic evidence for a causal association between IBD and dementia risk.The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.展开更多
Background and Purpose: In recent years, individual spirituality has been attracting attention, but little research has been conducted as it relates to family spirituality that applies this concept to the family and r...Background and Purpose: In recent years, individual spirituality has been attracting attention, but little research has been conducted as it relates to family spirituality that applies this concept to the family and relates to the meaning of the family’s existence in terms of the entire family. The purpose of this study was to clarify the attributes of family spirituality and the influencing factors of its decline. Methods: Regarding family spirituality, 1) a literature search was conducted using PubMed and reviews of 20 English-language articles;and 2) semi-structured interviews were conducted with 12 Japanese families having elderly members in the household. Data triangulation was performed for both, and a directed content analysis was conducted using Hohashi’s Concentric Sphere Family Environment Theory as the framework. Results: Attributes of family spirituality included 21 categories, such as “I think that my family exists for my children and grandchildren.” Factors influencing the decline in family spirituality included 20 categories in total, including 6 categories of risk/causal/promoting factors such as “lack of caring for family members”;11 categories of preventive/inhibitory/suppression factors such as “healthcare professionals not being close to the family”;and three categories of context-sensitive factors such as “death of a family member.” Conclusions/Implications for Practice: Family intervention requires nurses to understand the attributes of family spirituality and to control the influencing factors of a decline in family spirituality. Through such efforts, families will be able to discover the meaning of the existence of the family and maintain and improve their well-being.展开更多
Accurate measurement of the transverse position of a beam is crucial in particle accelerators because it plays a key role in determining the beam parameters.Existing methods for beam-position measurement rely on the d...Accurate measurement of the transverse position of a beam is crucial in particle accelerators because it plays a key role in determining the beam parameters.Existing methods for beam-position measurement rely on the detection of image currents induced on electrodes or narrow-band wake field induced by a beam passing through a cavity-type structure.However,these methods have limitations.The indirect measurement of multiple parameters is computationally complex,requiring external calibration to determine the system parameters in advance.Furthermore,the utilization of the beam signal information is incomplete.Hence,this study proposes a novel method for measuring the absolute electron beam transverse position.By utilizing the geometric relationship between the center position of the measured electron beam and multiple detection electrodes and by analyzing the differences in the arrival times of the beam signals detected by these electrodes,the absolute transverse position of the electron beam crossing the electrode plane can be calculated.This method features absolute position measurement,a position sensitivity coefficient independent of vacuum chamber apertures,and no requirement for a symmetrical detector electrode layout.The feasibility of this method is validated through numerical simulations and beam experiments.展开更多
To alleviate the distortion of XRII X-ray image intensifier images in the C-arm CT computer tomography imaging system an algorithm based on the Delaunay triangulation interpolation is proposed.First the causes of the ...To alleviate the distortion of XRII X-ray image intensifier images in the C-arm CT computer tomography imaging system an algorithm based on the Delaunay triangulation interpolation is proposed.First the causes of the phenomenon the classical correction algorithms and the Delaunay triangulation interpolation are analyzed.Then the algorithm procedure is explained using flow charts and illustrations. Finally experiments are described to demonstrate its effectiveness and feasibility. Experimental results demonstrate that the Delaunay triangulation interpolation can have the following effects.In the case of the same center the root mean square distances RMSD and standard deviation STD between the corrected image with Delaunay triangulation interpolation and the ideal image are 5.760 4 ×10 -14 and 5.354 2 ×10 -14 respectively.They increase to 1.790 3 2.388 8 2.338 8 and 1.262 0 1.268 1 1.202 6 after applying the quartic polynomial model L1 and model L2 to the distorted images respectively.The RMSDs and STDs between the corrected image with the Delaunay triangulation interpolation and the ideal image are 2.489 × 10 -13 and 2.449 8 ×10 -13 when their centers do not coincide. When the quartic polynomial model L1 and model L2 are applied to the distorted images they are 1.770 3 2.388 8 2.338 8 and 1.269 9 1.268 1 1.202 6 respectively.展开更多
In this work,we compute the Grothendieck groups of finite 2-Calabi-Yau triangulated categories with maximal rigid objects which are not cluster tilting.These finite 2-Calabi-Yau triangulated categories are divided int...In this work,we compute the Grothendieck groups of finite 2-Calabi-Yau triangulated categories with maximal rigid objects which are not cluster tilting.These finite 2-Calabi-Yau triangulated categories are divided into,by the work of Amiot[Bull.Soc.Math.France,2007,135(3):435-474](see also[Adv.Math.,2008,217(6):2443-2484]and[J.Algebra,2016,446:426-449]),three classes:type A,type D and type E.展开更多
基金supported by the China Postdoctoral Science Foundation(Grant No.2021M703366)Shenzhen Science and Technology Program(Grant No.KQTD20190929172835662).
文摘Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are inconsistent.It remains unclear whether these associations are causal.Methods We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia.Mendelian randomization(MR)analysis based on summary genome-wide association studies(GWASs)was performed.Genetic correlation and Bayesian colocalization analyses were used to provide robust genetic evidence.Results Ten observational studies involving 80,565,688 participants were included in this metaanalysis.IBD was significantly associated with dementia(risk ratio[RR]=1.36,95%CI=1.04-1.78;I2=84.8%)and VD(RR=2.60,95%CI=1.18-5.70;only one study),but not with AD(RR=2.00,95%CI=0.96-4.13;I^(2)=99.8%).MR analyses did not supported significant causal associations of IBD with dementia(dementia:odds ratio[OR]=1.01,95%CI=0.98-1.03;AD:OR=0.98,95%CI=0.95-1.01;VD:OR=1.02,95%CI=0.97-1.07).In addition,genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia.Conclusion Our study did not provide genetic evidence for a causal association between IBD and dementia risk.The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.
文摘Background and Purpose: In recent years, individual spirituality has been attracting attention, but little research has been conducted as it relates to family spirituality that applies this concept to the family and relates to the meaning of the family’s existence in terms of the entire family. The purpose of this study was to clarify the attributes of family spirituality and the influencing factors of its decline. Methods: Regarding family spirituality, 1) a literature search was conducted using PubMed and reviews of 20 English-language articles;and 2) semi-structured interviews were conducted with 12 Japanese families having elderly members in the household. Data triangulation was performed for both, and a directed content analysis was conducted using Hohashi’s Concentric Sphere Family Environment Theory as the framework. Results: Attributes of family spirituality included 21 categories, such as “I think that my family exists for my children and grandchildren.” Factors influencing the decline in family spirituality included 20 categories in total, including 6 categories of risk/causal/promoting factors such as “lack of caring for family members”;11 categories of preventive/inhibitory/suppression factors such as “healthcare professionals not being close to the family”;and three categories of context-sensitive factors such as “death of a family member.” Conclusions/Implications for Practice: Family intervention requires nurses to understand the attributes of family spirituality and to control the influencing factors of a decline in family spirituality. Through such efforts, families will be able to discover the meaning of the existence of the family and maintain and improve their well-being.
基金supported by the National Key R&D Program of China(No.2022YFA1602201)。
文摘Accurate measurement of the transverse position of a beam is crucial in particle accelerators because it plays a key role in determining the beam parameters.Existing methods for beam-position measurement rely on the detection of image currents induced on electrodes or narrow-band wake field induced by a beam passing through a cavity-type structure.However,these methods have limitations.The indirect measurement of multiple parameters is computationally complex,requiring external calibration to determine the system parameters in advance.Furthermore,the utilization of the beam signal information is incomplete.Hence,this study proposes a novel method for measuring the absolute electron beam transverse position.By utilizing the geometric relationship between the center position of the measured electron beam and multiple detection electrodes and by analyzing the differences in the arrival times of the beam signals detected by these electrodes,the absolute transverse position of the electron beam crossing the electrode plane can be calculated.This method features absolute position measurement,a position sensitivity coefficient independent of vacuum chamber apertures,and no requirement for a symmetrical detector electrode layout.The feasibility of this method is validated through numerical simulations and beam experiments.
基金The Natural Science Foundation of Anhui Province(No.1308085MF96)the Project of Chuzhou University(No.2012qd06,2011kj010B)+1 种基金the Scientific Research Foundation of Education Department of Anhui Province(No.KJ2014A186)the National Basic Research Program of China(973 Program)(No.2010CB732503)
文摘To alleviate the distortion of XRII X-ray image intensifier images in the C-arm CT computer tomography imaging system an algorithm based on the Delaunay triangulation interpolation is proposed.First the causes of the phenomenon the classical correction algorithms and the Delaunay triangulation interpolation are analyzed.Then the algorithm procedure is explained using flow charts and illustrations. Finally experiments are described to demonstrate its effectiveness and feasibility. Experimental results demonstrate that the Delaunay triangulation interpolation can have the following effects.In the case of the same center the root mean square distances RMSD and standard deviation STD between the corrected image with Delaunay triangulation interpolation and the ideal image are 5.760 4 ×10 -14 and 5.354 2 ×10 -14 respectively.They increase to 1.790 3 2.388 8 2.338 8 and 1.262 0 1.268 1 1.202 6 after applying the quartic polynomial model L1 and model L2 to the distorted images respectively.The RMSDs and STDs between the corrected image with the Delaunay triangulation interpolation and the ideal image are 2.489 × 10 -13 and 2.449 8 ×10 -13 when their centers do not coincide. When the quartic polynomial model L1 and model L2 are applied to the distorted images they are 1.770 3 2.388 8 2.338 8 and 1.269 9 1.268 1 1.202 6 respectively.
文摘In this work,we compute the Grothendieck groups of finite 2-Calabi-Yau triangulated categories with maximal rigid objects which are not cluster tilting.These finite 2-Calabi-Yau triangulated categories are divided into,by the work of Amiot[Bull.Soc.Math.France,2007,135(3):435-474](see also[Adv.Math.,2008,217(6):2443-2484]and[J.Algebra,2016,446:426-449]),three classes:type A,type D and type E.
