We conducted the ambient noise tomography to image the shallow crustal structure of southern Tibet. The2D maps of phase velocity anomalies at the periods of10–16 s show that the low velocities are mainly confined alo...We conducted the ambient noise tomography to image the shallow crustal structure of southern Tibet. The2D maps of phase velocity anomalies at the periods of10–16 s show that the low velocities are mainly confined along or near some of the rift zones. While the maps at the periods of 18–25 s show that the coherent patterns that the low velocities expand outside of the rift zones. It means that the low velocities are prevailing in the middle crust of southern Tibet. According to the previous study of surface wave tomography with teleseismic data,we find that the low velocities from the lower crust to the lithospheric mantle are also restricted to the same rift zones. Thus,the integrated knowledge of the distribution of the low velocities in southern Tibet provides some new insight on the formation of the north–south trending rift zones. Compiling the multidiscipline evidences,we conclude that the rifting was an integrated process of the entire lithosphere in the early stage（＊26–10 Ma）,but mainly occurred within the upper crust due to the weakening a decoupling in the low velocity middle crust in the late stage（later than ＊8 Ma）.展开更多
Over the next 20 years,China's urban rail transit(hereinafter referred to as'urban rail')will face large-scalerenovation of existing line facilities and equipment,with more than 1000 km of renovated lines ...Over the next 20 years,China's urban rail transit(hereinafter referred to as'urban rail')will face large-scalerenovation of existing line facilities and equipment,with more than 1000 km of renovated lines to be added eachyear.In 2024,the China Association of Metros issued the Guiding Opinions on the Renovation of Existing UrbanRail Transit Lines in China,providing guiding opinions on norms,standards,and implementation approaches forthe renovation of existing lines in the coming period.In the practical work of renovating existing urban rail lines,it is necessary to continuously explore and refine relevant theoretical methods in line with industry developmenttrends and urban development requirements.The following are the author's recent reflections on theoreticalinnovation in this field.展开更多
Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proo...Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proof on 28 September 2025 without any questions.However,on 13 November 2025,the Editorial Office of Medical Data Mining noticed an inconsistency between the data presented in the main text and Figure 1.Specifically,erroneous Figure 1 states“a total of 56,691 literatures were obtained through database search”,while the main text in the Search results section states“According to the search term,a total of 59,220 publications were retrieved from the database.”The authors acknowledge that the original version of Figure 1 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.展开更多
This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis...This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis,and Sen's slope estimation methods,historical climate trends(1980-2100)were analyzed,while land cover changes represented human impacts.Future projections were simulated using the MIROC model with Shared Socioeconomic Pathways(SSPs)and the Tank model.Results show that during the past 40 years,air temperature significantly increased(Z=3.93^(***)),while precipitation(Z=-1.54^(*))and river flow(Z=-1.73^(*))both declined.The Khyargas Lake water level dropped markedly(Z=-5.57***).Land cover analysis reveals expanded cropland and impervious areas due to human activity.Under the SSP1.26 scenario,which assumes minimal climate change,air temperature is projected to rise by 2.0℃,precipitation by 21.8 mm,and river discharge by 1.61 m^(3)/s between 2000 and 2100.These findings indicate that both global warming and intensified land use have substantially altered hydrological and climatic processes in the basin,highlighting the vulnerability of western Mongolia's water resources to combined climatic and anthropogenic influence.展开更多
Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Fa...Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Factors Surveillance)conducted between 2010 and 2018,a total of 645,420 adult participants(97,741 in 2010;175,749 in 2013;187,777 in 2015;and 184,153 in 2018)were included in the trend analysis.Linear and logistic regression models were utilized to assess trends in sleep duration.Results In 2018,the estimated overall mean sleep duration among the Chinese adult population was7.58(SD,1.45)hours per day,with no significant trend from 2010.A significant increase in short sleep duration(≤6 hours)was observed in the total population,from 15.3%(95%CI:14.1%–16.5%)in 2010 to18.5%(95%CI:17.7%–19.3%)in 2018(P<0.001).Similarly,the trend in long sleep duration(>9 hours)was also significant,increasing in weighted prevalence from 7.2%(95%CI:6.3%–8.1%)in 2010 to 9.0%(95%CI:8.2%–9.9%)in 2018(P<0.001).Conclusion The prevalence of both short and long sleep durations significantly increased among Chinese adults from 2010 to 2018,highlighting the urgency of health initiatives to promote optimal sleep duration in China.展开更多
Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analys...Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analyses to systematically examine the spatiotemporal patterns of runoff and its climatic driving mechanisms across Tajikistan,providing a scientific basis for sustainable water resource utilization and management in the study area.Results indicated that during 2000–2024,the annual runoff in Tajikistan exhibited statistically non-significant long-term trend(P=0.76),while displaying pronounced seasonal variability and strong spatial heterogeneity.Spring and summer average runoff primarily exhibited slight declining tendencies,while winter average runoff exhibited pronounced reduction in localized regions,such as the Syr Darya Basin,the Vakhsh River Basin,and the lower reaches of the Zeravshan River Basin.Precipitation emerged as the dominant positive driver of runoff,exhibiting moderate to strong positive correlations across over 78.00%of the country,whereas potential evapotranspiration consistently functioned as a negative driver.Rising temperatures exerted a dual competitive effect on runoff:in high-elevation,glacier-covered regions,rising temperatures temporarily increased runoff by accelerating glacier melt;however,at the national scale,the negative impact of rising temperature on runoff has played a slightly dominant role to a certain extent by enhancing evapotranspiration.Collectively,these results indicated that the present stability of runoff in Tajikistan is strongly dependent on the short-term compensatory effects of glacier melt and the risk of future runoff decline is likely to intensify as glacier reserves continue to diminish.This study provides a critical scientific evidence to inform sustainable water resource management in Tajikistan and underscores the need for glacier conservation and integrated water resource management strategies.展开更多
Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical ca...Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.展开更多
Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based ...Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based on the GLOBOCAN 2022,the age-standardized incidence rate(ASIR)and mortality rate(ASMR)were compared and linked to the Human Development Index(HDI)across different populations.The temporal trends in ASIR/ASMR were characterized as estimated annual percentage change(EAPC),and demographic projections were performed up to 2050.Results Globally,an estimated 2,480,675 cases and 1,817,469 deaths from lung cancer occurred in 2022.Both ASIR and ASMR of lung cancer varied widely by world region,with ASIR ranging from 2.06 to 39.38 per 100,000 and ASMR from 1.95 to 31.70 per 100,000.China alone accounted for>40%of cases and deaths worldwide.Both ASIR and ARMR of lung cancer increased with HDI(R2:0.54 and 0.47,all P values<0.001),regardless of gender.Based on available data,both ASIR during 2001–2010 and ASMR during 2001–2015 showed decreasing trends in males(EAPC:1.50%and−2.22%)but increasing trends in females(EAPC:1.08%and 0.07%).Similar trends in ASIR and ASMR were observed among the elder population(≥50 years);however,downward trends were observed in the younger population(<50 years).Alongside the aging and growth of the population,estimated cases and deaths from overall lung cancer would increase by 86.2%and 95.2%up to 2050 as compared with estimates in 2022,respectively.Notably,increased early-onset lung cancer was only observed in transitioning countries,while decreased early-onset lung cancer was observed in transitioned countries.Conclusion Lung cancer maintained as the leading cancer burden worldwide.Unless timely preventive interventions in tobacco mitigation,early screening,and precise treatment,the global lung cancer burden is expected to increase in the future,especially for transitioning countries.展开更多
Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the gl...Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the global burden of esophageal,gastric,and liver cancers in 2022 and analyzes the trends of age-standardized incidence and mortality rate(ASRs)in China from 2000 to 2018,thereby providing evidence for the formulation of cancer control strategies.Methods The global burden of esophageal,gastric and liver cancers including the estimated number of cases and deaths and the ASRs for incidence and mortality were from GLOBALCAN 2022 dataset.Data from 22 cancer registries in China were employed for the trend analysis of the ASRs for incidence and mortality of these three cancers.The Joinpoint model was used to compute the average annual percentage change(AAPC)of the incidence and mortality of the three cancers from 2000 to 2018.Results Globally,esophageal,gastric and liver cancers accounted for 11.8%of incident cancer cases and 19.1%of cancer deaths.China bore a disproportionately high burden,representing 43.8%,37.0%,and 42.4%of global esophageal,gastric,and liver cancer cases respectively,and 42.1%,39.4%,and 41.7%of corresponding deaths.However,the ASRs for incidence and mortality for all three cancers declined significantly in China(2000–2018),with absolute case numbers decreasing for gastric and esophageal cancers during 2010–2022.Age-specific analysis revealed most pronounced declines in incidence and mortality in populations under 40 years old,with AAPCs of less than–6.0%for esophageal cancer,around–4.0%for gastric cancer,and approximately–2.0%for liver cancer.Conclusions China has achieved remarkable progress in controlling esophageal,gastric and liver cancers,yet these malignancies remain major public health challenges.Future efforts should intensify existing prevention measures while expanding screening programs,particularly for aging populations.These findings offer valuable insights for regions undergoing similar epidemiological transitions.展开更多
Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examine...Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.展开更多
Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 count...Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 countries and territories from 1990 to 2019 and predicted future incidence trends through 2034.Methods COPD data by age and sex from the GBD 2019 database were analyzed for incidence,prevalence,mortality,and disability-adjusted life years(DALY)rates from 1990 to 2019.Joinpoint regression identified significant annual trends,and age-standardized incidence rates were predicted through 2034 using age-period-cohort models.Results The incidence,prevalence,mortality,and disease burden of COPD have been decreasing,and the incidence rates will continue to decrease or remain stable until 2034 in most selected countries and territories,except for a few Southeastern Asian countries.The Lao People’s Democratic Republic and Vietnam are projected to experience an increase in COPD incidence from 165.3 per 100,000 in 2019 to 177 per 100,000 in 2034 and from 179.9 per 100,000 in 2019 to 192.5 per 100,000 in 2034,respectively.Older males had a higher incidence than any other sex or age group.The sex gap in incidence rates continues to widen,though it is smaller and less significant in the younger age group than in those in the older one.Conclusion COPD rates are expected to decline until 2034 but remain a health risk,especially in countries with rising rates.Urgent action on tobacco control,air pollution,and public education is needed.展开更多
Objective This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods This study utilized Global Burden of Disease(GBD)1990-2050 prediction data to analyze...Objective This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods This study utilized Global Burden of Disease(GBD)1990-2050 prediction data to analyze changes in mortality rates and disability-adjusted life year(DALY)rates for lower respiratory infections in the elderly population(aged 70 and above)in China from 1990 to 2050.It also discusses future trends in the burden of lower respiratory infections(LRI)in China under different scenarios.Results According to GBD predictions,the burden of lower respiratory infections in the elderly aged 70 years and above in China is lower than the global average.The burden has been decreasing from 1990 to 2020,but is projected to increase from 2020 to 2050.Scenario-based predictions suggest that,under scenarios involving improvements in nutrition and vaccination,the burden of lower respiratory infections in the elderly in China is expected to be the lowest in 2050.Conclusion This study indicates that the burden of lower respiratory infections in elderly people aged 70 years and above in China remains a significant public health issue and may worsen.The government should consider strengthening the preventive measures and management strategies for respiratory infections in the elderly population.展开更多
Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pest...Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pests and their natural enemies is required to minimize the pest population and yield losses.In the current study,analysis of the seasonal population trend of pests and natural enemies and their relative occurrence on cultivars of three cotton species in Central India has been carried out.Results A higher number and diversity of sucking pests were observed during the vegetative cotton growth stage(60 days after sowing),declining as the crop matured.With the exception of cotton jassid(Amrasca biguttula biguttula Ishida),which caused significant crop damage mainly from August to September;populations of other sucking insects seldom reached economic threshold levels(ETL)throughout the studied period.The bollworm complex populations were minimal,except for the pink bollworm(Pectinophora gossypiella Saunders),which re-emerged as a menace to cotton crops during the cotton cropping season 2017–2018 due to resistance development against Bt-cotton.A reasonably good number of predatory arthropods,including coccinellids,lacewings,and spiders,were found actively preying on the arthropod pest complex of the cotton crop during the early vegetative growth stage.Linear regression indicates a significant relationship between green boll infestations and pink bollworm moths in pheromone traps.Multiple linear regression analyse showed mean weekly weather at one-or two-week lag periods had a significant impact on sucking pest population(cotton aphid,cotton jassid,cotton whitefly,and onion thrips)fluctuation.Gossypium hirsutum cultivars RCH 2 and DCH 32,and G.barbadense cultivar Suvin were found susceptible to cotton jassid and onion thrips.Phule Dhanvantary,an G.arboreum cotton cultivar,demonstrated the highest tolerance among all evaluated cultivars against all sucking pests.Conclusion These findings have important implications for pest management in cotton crops.Susceptible cultivars warrant more attention for plant protection measures,making them more input-intensive.The choice of appropriate cultivars can help minimize input costs,thereby increasing net returns for cotton farmers.展开更多
Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition wi...Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.展开更多
Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyro...Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyroidism.This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them.To the best of our knowledge,this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States.In this 21-year analysis of mortality data,we found a constant increase in mortality rates due to AF/AFL in older adults.From 1999 to 2020,the overall mortality in older adults aged 65 and above,regardless of sex and race,is found to be almost doubled i.e.about a 50.2%increase in the number of deaths due to AF/AFL.Furthermore,other confounding risk factors such has obesity,prior myocardial infarction,inflammation,hypertension,birth weight,diabetes mellitus,hyperthyroidism,hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.展开更多
Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were ...Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.展开更多
Mesoscale eddies play a central role in the poleward oceanic heat flux in the Southern Ocean.Previous studies have documented changes in the location of temperature fronts in the Southern Ocean,but little attention ha...Mesoscale eddies play a central role in the poleward oceanic heat flux in the Southern Ocean.Previous studies have documented changes in the location of temperature fronts in the Southern Ocean,but little attention has been paid to changes in the genesis locations of mesoscale eddies.Here,we provide evidence from three decades of satellite altimetry observations for the heterogeneity of the poleward shift of mesoscale activities,with the largest trend of~0.23°±0.05°(10 yr)^(-1) over the Atlantic sector and a moderate trend of~0.1°±0.03°(10 yr)^(-1) over the Indian sector,but no significant trend in the Pacific sector.The poleward shift of mesoscale eddies is associated with a southward shift of the local westerly winds while being constrained by the major topographies.As the poleward shift of westerly winds is projected to persist,the poleward oceanic heat flux from mesoscale eddies may influence future ice melt.展开更多
BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel treatments.Ubiquitination,an intracellular protein modification process,is emerging as a promising strategy for regulating ...BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel treatments.Ubiquitination,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological mechanisms.We hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic approaches.AIM To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric analysis.METHODS Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core Collection.Visual mapping analysis was conducted using the CiteSpace software.RESULTS We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated complications.These articles originated from 54 countries and 386 institutions,with China as the leading contributor.Shanghai Jiao Tong University has the highest number of publications in this field.The most prominent authors contributing to this research area include Wei-Hua Zhang,with Zhang Y being the most frequently cited author.Additionally,The Journal of Biological Chemistry is noted as the most cited in this field.The predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin resistance.CONCLUSION The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research focus.However,these areas require further investigations.展开更多
基金funded by the National Natural Science Foundation of China (Grant No.: 41274002 and 41125015)
文摘We conducted the ambient noise tomography to image the shallow crustal structure of southern Tibet. The2D maps of phase velocity anomalies at the periods of10–16 s show that the low velocities are mainly confined along or near some of the rift zones. While the maps at the periods of 18–25 s show that the coherent patterns that the low velocities expand outside of the rift zones. It means that the low velocities are prevailing in the middle crust of southern Tibet. According to the previous study of surface wave tomography with teleseismic data,we find that the low velocities from the lower crust to the lithospheric mantle are also restricted to the same rift zones. Thus,the integrated knowledge of the distribution of the low velocities in southern Tibet provides some new insight on the formation of the north–south trending rift zones. Compiling the multidiscipline evidences,we conclude that the rifting was an integrated process of the entire lithosphere in the early stage（＊26–10 Ma）,but mainly occurred within the upper crust due to the weakening a decoupling in the low velocity middle crust in the late stage（later than ＊8 Ma）.
文摘Over the next 20 years,China's urban rail transit(hereinafter referred to as'urban rail')will face large-scalerenovation of existing line facilities and equipment,with more than 1000 km of renovated lines to be added eachyear.In 2024,the China Association of Metros issued the Guiding Opinions on the Renovation of Existing UrbanRail Transit Lines in China,providing guiding opinions on norms,standards,and implementation approaches forthe renovation of existing lines in the coming period.In the practical work of renovating existing urban rail lines,it is necessary to continuously explore and refine relevant theoretical methods in line with industry developmenttrends and urban development requirements.The following are the author's recent reflections on theoreticalinnovation in this field.
文摘Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proof on 28 September 2025 without any questions.However,on 13 November 2025,the Editorial Office of Medical Data Mining noticed an inconsistency between the data presented in the main text and Figure 1.Specifically,erroneous Figure 1 states“a total of 56,691 literatures were obtained through database search”,while the main text in the Search results section states“According to the search term,a total of 59,220 publications were retrieved from the database.”The authors acknowledge that the original version of Figure 1 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.
基金The National University of Mongolia,No.P2024-4814The Mongolian Science and Technology Foundation,No.CHN-2022/274The‘Chey Institute for Advanced Studies’International Scholar Exchange Fellowship for the Academic Year of 2025-2026。
文摘This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis,and Sen's slope estimation methods,historical climate trends(1980-2100)were analyzed,while land cover changes represented human impacts.Future projections were simulated using the MIROC model with Shared Socioeconomic Pathways(SSPs)and the Tank model.Results show that during the past 40 years,air temperature significantly increased(Z=3.93^(***)),while precipitation(Z=-1.54^(*))and river flow(Z=-1.73^(*))both declined.The Khyargas Lake water level dropped markedly(Z=-5.57***).Land cover analysis reveals expanded cropland and impervious areas due to human activity.Under the SSP1.26 scenario,which assumes minimal climate change,air temperature is projected to rise by 2.0℃,precipitation by 21.8 mm,and river discharge by 1.61 m^(3)/s between 2000 and 2100.These findings indicate that both global warming and intensified land use have substantially altered hydrological and climatic processes in the basin,highlighting the vulnerability of western Mongolia's water resources to combined climatic and anthropogenic influence.
基金supported by the National Natural Science Foundation of China(82341245,82371491)the Chinese Central Government(Key Project of Public Health Program)the National Key Research and Development Program of China(2018YFC1311706,2018YFC1311702)。
文摘Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Factors Surveillance)conducted between 2010 and 2018,a total of 645,420 adult participants(97,741 in 2010;175,749 in 2013;187,777 in 2015;and 184,153 in 2018)were included in the trend analysis.Linear and logistic regression models were utilized to assess trends in sleep duration.Results In 2018,the estimated overall mean sleep duration among the Chinese adult population was7.58(SD,1.45)hours per day,with no significant trend from 2010.A significant increase in short sleep duration(≤6 hours)was observed in the total population,from 15.3%(95%CI:14.1%–16.5%)in 2010 to18.5%(95%CI:17.7%–19.3%)in 2018(P<0.001).Similarly,the trend in long sleep duration(>9 hours)was also significant,increasing in weighted prevalence from 7.2%(95%CI:6.3%–8.1%)in 2010 to 9.0%(95%CI:8.2%–9.9%)in 2018(P<0.001).Conclusion The prevalence of both short and long sleep durations significantly increased among Chinese adults from 2010 to 2018,highlighting the urgency of health initiatives to promote optimal sleep duration in China.
基金funded by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0720203)the National Key Research and Development Program of China(2023YFF0805603).
文摘Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analyses to systematically examine the spatiotemporal patterns of runoff and its climatic driving mechanisms across Tajikistan,providing a scientific basis for sustainable water resource utilization and management in the study area.Results indicated that during 2000–2024,the annual runoff in Tajikistan exhibited statistically non-significant long-term trend(P=0.76),while displaying pronounced seasonal variability and strong spatial heterogeneity.Spring and summer average runoff primarily exhibited slight declining tendencies,while winter average runoff exhibited pronounced reduction in localized regions,such as the Syr Darya Basin,the Vakhsh River Basin,and the lower reaches of the Zeravshan River Basin.Precipitation emerged as the dominant positive driver of runoff,exhibiting moderate to strong positive correlations across over 78.00%of the country,whereas potential evapotranspiration consistently functioned as a negative driver.Rising temperatures exerted a dual competitive effect on runoff:in high-elevation,glacier-covered regions,rising temperatures temporarily increased runoff by accelerating glacier melt;however,at the national scale,the negative impact of rising temperature on runoff has played a slightly dominant role to a certain extent by enhancing evapotranspiration.Collectively,these results indicated that the present stability of runoff in Tajikistan is strongly dependent on the short-term compensatory effects of glacier melt and the risk of future runoff decline is likely to intensify as glacier reserves continue to diminish.This study provides a critical scientific evidence to inform sustainable water resource management in Tajikistan and underscores the need for glacier conservation and integrated water resource management strategies.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)National Natural Science Foundation of China(grant numbers:82172894,82073028,82204121)China Postdoctoral Science Foundation(grant number:2023M742617).
文摘Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.
基金supported by the National Key Research and Development Program of China(grant number:2021YFC2500400)Tianjin Health Committee Foundation(grant number:TJWJ2021MS008)+2 种基金Tianjin Key Medical Discipline(Specialty)Construction Project(grant number:TYXZDXK-009A)Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences(grant number:2023GLLH0132)Scientific Research Fund for the Demonstration Project of Public Hospital Reform and Quality Development(Gastrointestinal Tumour)that is approved by Peking University Cancer Hospital(Inner Mongolia Campus)(grant number:2023SGGZ068)。
文摘Background Given the relatively unfavorable prognosis and significant geographic differences in lung cancer burden,it is critical to update the global landscape of lung cancer to inform local strategies.Methods Based on the GLOBOCAN 2022,the age-standardized incidence rate(ASIR)and mortality rate(ASMR)were compared and linked to the Human Development Index(HDI)across different populations.The temporal trends in ASIR/ASMR were characterized as estimated annual percentage change(EAPC),and demographic projections were performed up to 2050.Results Globally,an estimated 2,480,675 cases and 1,817,469 deaths from lung cancer occurred in 2022.Both ASIR and ASMR of lung cancer varied widely by world region,with ASIR ranging from 2.06 to 39.38 per 100,000 and ASMR from 1.95 to 31.70 per 100,000.China alone accounted for>40%of cases and deaths worldwide.Both ASIR and ARMR of lung cancer increased with HDI(R2:0.54 and 0.47,all P values<0.001),regardless of gender.Based on available data,both ASIR during 2001–2010 and ASMR during 2001–2015 showed decreasing trends in males(EAPC:1.50%and−2.22%)but increasing trends in females(EAPC:1.08%and 0.07%).Similar trends in ASIR and ASMR were observed among the elder population(≥50 years);however,downward trends were observed in the younger population(<50 years).Alongside the aging and growth of the population,estimated cases and deaths from overall lung cancer would increase by 86.2%and 95.2%up to 2050 as compared with estimates in 2022,respectively.Notably,increased early-onset lung cancer was only observed in transitioning countries,while decreased early-onset lung cancer was observed in transitioned countries.Conclusion Lung cancer maintained as the leading cancer burden worldwide.Unless timely preventive interventions in tobacco mitigation,early screening,and precise treatment,the global lung cancer burden is expected to increase in the future,especially for transitioning countries.
基金supported by the National Natural Science Foundation of China(grant numbers:82273721,82304220)Cooperation Fund of CHCAMS and SZCH(grant number:CFA202201003).
文摘Background While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers,comprehensive data on esophageal,gastric,and liver cancer burden remain limited.This study examines the global burden of esophageal,gastric,and liver cancers in 2022 and analyzes the trends of age-standardized incidence and mortality rate(ASRs)in China from 2000 to 2018,thereby providing evidence for the formulation of cancer control strategies.Methods The global burden of esophageal,gastric and liver cancers including the estimated number of cases and deaths and the ASRs for incidence and mortality were from GLOBALCAN 2022 dataset.Data from 22 cancer registries in China were employed for the trend analysis of the ASRs for incidence and mortality of these three cancers.The Joinpoint model was used to compute the average annual percentage change(AAPC)of the incidence and mortality of the three cancers from 2000 to 2018.Results Globally,esophageal,gastric and liver cancers accounted for 11.8%of incident cancer cases and 19.1%of cancer deaths.China bore a disproportionately high burden,representing 43.8%,37.0%,and 42.4%of global esophageal,gastric,and liver cancer cases respectively,and 42.1%,39.4%,and 41.7%of corresponding deaths.However,the ASRs for incidence and mortality for all three cancers declined significantly in China(2000–2018),with absolute case numbers decreasing for gastric and esophageal cancers during 2010–2022.Age-specific analysis revealed most pronounced declines in incidence and mortality in populations under 40 years old,with AAPCs of less than–6.0%for esophageal cancer,around–4.0%for gastric cancer,and approximately–2.0%for liver cancer.Conclusions China has achieved remarkable progress in controlling esophageal,gastric and liver cancers,yet these malignancies remain major public health challenges.Future efforts should intensify existing prevention measures while expanding screening programs,particularly for aging populations.These findings offer valuable insights for regions undergoing similar epidemiological transitions.
基金supported by the Guangdong Basic and Applied Basic Research project (No.2020B0301030004)the Key-Area Research and Development Program of Guangdong Province (No.2020B1111360003)+1 种基金the National Natural Science Foundation of China (No.42105103)the Guangdong Basic and Applied Basic Research Foundation (No.2022A1515011554).
文摘Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.
基金supported by a major project of the Zhejiang Natural Science Foundation(LD21G030001).
文摘Objective The Asia-Pacific region has a high chronic obstructive pulmonary disease(COPD)burden,but studies on its trends are limited.Using the Global Burden of Disease(GBD)2019 data,we analyzed COPD trends in 36 countries and territories from 1990 to 2019 and predicted future incidence trends through 2034.Methods COPD data by age and sex from the GBD 2019 database were analyzed for incidence,prevalence,mortality,and disability-adjusted life years(DALY)rates from 1990 to 2019.Joinpoint regression identified significant annual trends,and age-standardized incidence rates were predicted through 2034 using age-period-cohort models.Results The incidence,prevalence,mortality,and disease burden of COPD have been decreasing,and the incidence rates will continue to decrease or remain stable until 2034 in most selected countries and territories,except for a few Southeastern Asian countries.The Lao People’s Democratic Republic and Vietnam are projected to experience an increase in COPD incidence from 165.3 per 100,000 in 2019 to 177 per 100,000 in 2034 and from 179.9 per 100,000 in 2019 to 192.5 per 100,000 in 2034,respectively.Older males had a higher incidence than any other sex or age group.The sex gap in incidence rates continues to widen,though it is smaller and less significant in the younger age group than in those in the older one.Conclusion COPD rates are expected to decline until 2034 but remain a health risk,especially in countries with rising rates.Urgent action on tobacco control,air pollution,and public education is needed.
基金supported by the National High Level Hospital Clinical Research Funding(No.BJ-2023-066).
文摘Objective This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.Methods This study utilized Global Burden of Disease(GBD)1990-2050 prediction data to analyze changes in mortality rates and disability-adjusted life year(DALY)rates for lower respiratory infections in the elderly population(aged 70 and above)in China from 1990 to 2050.It also discusses future trends in the burden of lower respiratory infections(LRI)in China under different scenarios.Results According to GBD predictions,the burden of lower respiratory infections in the elderly aged 70 years and above in China is lower than the global average.The burden has been decreasing from 1990 to 2020,but is projected to increase from 2020 to 2050.Scenario-based predictions suggest that,under scenarios involving improvements in nutrition and vaccination,the burden of lower respiratory infections in the elderly in China is expected to be the lowest in 2050.Conclusion This study indicates that the burden of lower respiratory infections in elderly people aged 70 years and above in China remains a significant public health issue and may worsen.The government should consider strengthening the preventive measures and management strategies for respiratory infections in the elderly population.
基金Funding support for the Crop Pest Surveillance and Advisory Project(CROPSAP)。
文摘Background Cotton crop is infested by numerous arthropod pests from sowing to harvesting,causing substantial direct and indirect yield losses.Knowledge of seasonal population trends and the relative occurrence of pests and their natural enemies is required to minimize the pest population and yield losses.In the current study,analysis of the seasonal population trend of pests and natural enemies and their relative occurrence on cultivars of three cotton species in Central India has been carried out.Results A higher number and diversity of sucking pests were observed during the vegetative cotton growth stage(60 days after sowing),declining as the crop matured.With the exception of cotton jassid(Amrasca biguttula biguttula Ishida),which caused significant crop damage mainly from August to September;populations of other sucking insects seldom reached economic threshold levels(ETL)throughout the studied period.The bollworm complex populations were minimal,except for the pink bollworm(Pectinophora gossypiella Saunders),which re-emerged as a menace to cotton crops during the cotton cropping season 2017–2018 due to resistance development against Bt-cotton.A reasonably good number of predatory arthropods,including coccinellids,lacewings,and spiders,were found actively preying on the arthropod pest complex of the cotton crop during the early vegetative growth stage.Linear regression indicates a significant relationship between green boll infestations and pink bollworm moths in pheromone traps.Multiple linear regression analyse showed mean weekly weather at one-or two-week lag periods had a significant impact on sucking pest population(cotton aphid,cotton jassid,cotton whitefly,and onion thrips)fluctuation.Gossypium hirsutum cultivars RCH 2 and DCH 32,and G.barbadense cultivar Suvin were found susceptible to cotton jassid and onion thrips.Phule Dhanvantary,an G.arboreum cotton cultivar,demonstrated the highest tolerance among all evaluated cultivars against all sucking pests.Conclusion These findings have important implications for pest management in cotton crops.Susceptible cultivars warrant more attention for plant protection measures,making them more input-intensive.The choice of appropriate cultivars can help minimize input costs,thereby increasing net returns for cotton farmers.
基金supported by Ningbo Natural Science Foundation(No.2023J059)Ningbo Commonweal Programme Key Project(No.2023S038)Guangxi Key Research and Development Programme(No.GuikeAB21220063).
文摘Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.
文摘Atrial fibrillation(AF)/atrial flutter(AFL)is the most common sustained cardiac arrhythmia.The known risk factors for developing AF/AFL include age,structural heart disease,hypertension,diabetes mellitus,or hyperthyroidism.This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them.To the best of our knowledge,this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States.In this 21-year analysis of mortality data,we found a constant increase in mortality rates due to AF/AFL in older adults.From 1999 to 2020,the overall mortality in older adults aged 65 and above,regardless of sex and race,is found to be almost doubled i.e.about a 50.2%increase in the number of deaths due to AF/AFL.Furthermore,other confounding risk factors such has obesity,prior myocardial infarction,inflammation,hypertension,birth weight,diabetes mellitus,hyperthyroidism,hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)Tianjin Health Committee Foundation(grant number:TJWJ2021MS008).
文摘Background Breast cancer(BC)incidence and mortality vary significantly across countries,highlighting the need to update the global burden of female BC,including current trends and future projections.Methods Data were sourced from GLOBOCAN 2022,including estimated new cases and deaths from BC across 21 United Nation(UN)regions and 185 countries,the age-standardized incidence rate(ASIR)and mortality rate(ASMR),the estimated annual percentage changes(EAPC),and demographic projections through 2050.The region-specific and country-specific BC burden for women of all ages and for young women(<40 years old)was reorganized and re-plotted to highlight subgroup differences.Linear regression was used to explore the link between ASIR/ASMR and the human development index(HDI).Transitioning countries referred to those with low or medium HDI,while transitioned countries were those with high or very high HDI.Results In 2022,an estimated 2.3 million new BC cases and 666,000 BC-related deaths occurred globally,accounting for 23.8%and 15.4%of all cancer cases and deaths in women,respectively.Regionally,Eastern Asia reported the highest number of cases(480,019,ASIR:37.54/100,000),while South-Central Asia had the highest number of deaths(135,348,ASMR:13.41/100,000).At the country level,China had the highest number of cases due to its large population,whereas India reported the highest number of deaths.ASIR for both overall and early-onset BC increased with HDI,while ASMR for early-onset BC decreased with HDI(P<0.05).Overall BC showed an increasing trend in ASIR during 2003–2015(EAPC:0.92%)and a decreasing trend in ASMR during 2006–2016(EAPC:-1.06%).Early-onset BC showed a more significant rise in ASIR(EAPCs:1.4%)and a slight increase in ASMR(EAPCs:0.16%).If national rates remain stable,BC cases and deaths will increase by 54.7%and 70.9%,respectively,by 2050.Notably,increased early-onset BC cases are only observed in transitioning countries,while decreased cases are seen in transitioned countries.Conclusions Breast cancer remains the leading cancer burden in women,particularly in transitioning countries.Addressing this growing burden requires urgent integration of primary prevention,early detection and high-quality treatment through multi-sectoral collaboration.
基金supported by the National Natural Science Foundation of China(Grant Nos.42230405,42006029)Science and Technology Plan of Liaoning Province(2024JH2/102400061)+1 种基金Dalian Science and Technology Innovation Fund(2024JJ11PT007)Dalian Science and Technology Pro-gram for Innovation Talents of Dalian(2022RJ06).
文摘Mesoscale eddies play a central role in the poleward oceanic heat flux in the Southern Ocean.Previous studies have documented changes in the location of temperature fronts in the Southern Ocean,but little attention has been paid to changes in the genesis locations of mesoscale eddies.Here,we provide evidence from three decades of satellite altimetry observations for the heterogeneity of the poleward shift of mesoscale activities,with the largest trend of~0.23°±0.05°(10 yr)^(-1) over the Atlantic sector and a moderate trend of~0.1°±0.03°(10 yr)^(-1) over the Indian sector,but no significant trend in the Pacific sector.The poleward shift of mesoscale eddies is associated with a southward shift of the local westerly winds while being constrained by the major topographies.As the poleward shift of westerly winds is projected to persist,the poleward oceanic heat flux from mesoscale eddies may influence future ice melt.
基金Supported by Key Project of Anhui Provincial Education Department,No.2022AH050486and 2021 High-level Talent Introduction Scientific Project of Anhui University of Chinese Medicine,No.2022rczd005.
文摘BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel treatments.Ubiquitination,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological mechanisms.We hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic approaches.AIM To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric analysis.METHODS Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core Collection.Visual mapping analysis was conducted using the CiteSpace software.RESULTS We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated complications.These articles originated from 54 countries and 386 institutions,with China as the leading contributor.Shanghai Jiao Tong University has the highest number of publications in this field.The most prominent authors contributing to this research area include Wei-Hua Zhang,with Zhang Y being the most frequently cited author.Additionally,The Journal of Biological Chemistry is noted as the most cited in this field.The predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin resistance.CONCLUSION The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research focus.However,these areas require further investigations.
