Trapidil.a platelet-derived growth factor antagonist.has a beneficial effect onatherosclerosis and restenosis after PTCA.This study was to evaluste its clini-cal therapeutic efficacy for dislipidemia.62 consecutive pa...Trapidil.a platelet-derived growth factor antagonist.has a beneficial effect onatherosclerosis and restenosis after PTCA.This study was to evaluste its clini-cal therapeutic efficacy for dislipidemia.62 consecutive patients with primarydislipidemia were randomly divided into two groups.Group A(n=32)receivedtrapidil 300 mg daily and group B(n=30)with lovastatin 20 mg daily for 6 we-eks.After 6-week treatment,the results were showed in table 1.With trapidil,plasma TC and LDL significantly decreased by 12.5% and 11%,HDL signi-ficantly increased by 11.7%(P【0.05).The former effects were inferior to lov-astatin(P【0.001).Trapidil has a beneficial effect on lipid metabolism whichsignificantly decreased TC,LDL and increased HDL,but the effects were in-ferior to lovastatin.Table 1.Lipid and lipoprotein Valuca after Treatment(x±s)Compared with pretreatment.*P】0.05,**P【0.05.***P【0,01,****P【0.001Compared aronp A with B,a P】0.05,b P【0 05,c P【0.01,d P【0.001.展开更多
文摘Trapidil.a platelet-derived growth factor antagonist.has a beneficial effect onatherosclerosis and restenosis after PTCA.This study was to evaluste its clini-cal therapeutic efficacy for dislipidemia.62 consecutive patients with primarydislipidemia were randomly divided into two groups.Group A(n=32)receivedtrapidil 300 mg daily and group B(n=30)with lovastatin 20 mg daily for 6 we-eks.After 6-week treatment,the results were showed in table 1.With trapidil,plasma TC and LDL significantly decreased by 12.5% and 11%,HDL signi-ficantly increased by 11.7%(P【0.05).The former effects were inferior to lov-astatin(P【0.001).Trapidil has a beneficial effect on lipid metabolism whichsignificantly decreased TC,LDL and increased HDL,but the effects were in-ferior to lovastatin.Table 1.Lipid and lipoprotein Valuca after Treatment(x±s)Compared with pretreatment.*P】0.05,**P【0.05.***P【0,01,****P【0.001Compared aronp A with B,a P】0.05,b P【0 05,c P【0.01,d P【0.001.
