The idea of network splitting according to time delay and weight is introduced.Based on the cyber physical systems(CPS),a class of multi-weighted complex transportation networks with multiple delays is modeled.The fin...The idea of network splitting according to time delay and weight is introduced.Based on the cyber physical systems(CPS),a class of multi-weighted complex transportation networks with multiple delays is modeled.The finite-time synchronization of the proposed complex transportation networks model is studied systematically.On the basis of the theory of stability,the technique of adaptive control,aperiodically intermittent control and finite-time control,the aperiodically intermittent adaptive finite-time synchronization controller is designed.The controller designed in this paper is beneficial for understanding the synchronization in multi-weighted complex transportation networks with multiple delays.In addition,the conditions for the existence of finite time synchronization have been discussed in detail.And the specific value of the settling finite time for synchronization is obtained.Moreover,the outer coupling configuration matrices are not required to be irreducible or symmetric.Finally,simulation results of the finite-time synchronization problem are given to illustrate the correctness of the results obtained.展开更多
We propose a self-organized optimization mechanism to improve the transport capacity of complex gradient networks. We find that, regardless of network topology, the congestion pressure can be strongly reduced by the s...We propose a self-organized optimization mechanism to improve the transport capacity of complex gradient networks. We find that, regardless of network topology, the congestion pressure can be strongly reduced by the self-organized optimization mechanism. Furthermore, the random scale-free topology is more efficient to reduce congestion compared with the random Poisson topology under the optimization mechanism. The reason is that the optimization mechanism introduces the correlations between the gradient field and the local topology of the substrate network. Due to the correlations, the cutoff degree of the gradient network is strongly reduced and the number of the nodes exerting their maximal transport capacity consumedly increases. Our work presents evidence supporting the idea that scale-free networks can efficiently improve their transport capacity by self- organized mechanism under gradient-driven transport mode.展开更多
Human immunodeficiency virus-1(HIV-1)encodes simply 15 proteins and thus depends on multiple host cellular factors for virus reproduction.Spastin,a microtubule severing protein,is an identified HIV-1 dependency factor...Human immunodeficiency virus-1(HIV-1)encodes simply 15 proteins and thus depends on multiple host cellular factors for virus reproduction.Spastin,a microtubule severing protein,is an identified HIV-1 dependency factor,but the mechanism regulating HIV-1 is unclear.Here,the study showed that knockdown of spastin inhibited the production of the intracellular HIV-1 Gag protein and new virions through enhancing Gag lysosomal degradation.Further investigation showed that increased sodium tolerance 1(IST1),the subunit of endosomal sorting complex required for transport(ESCRT),could interact with the MIT domain of spastin to regulate the intracellular Gag production.In summary,spastin is required for HIV-1 replication,while spastin-IST1 interaction facilitates virus production by regulating HIV-1 Gag intracellular trafficking and degradation.Spastin may serve as new target for HIV-1 prophylactic and therapy.展开更多
Distribution and activity of mitochondda are key factors in neuronal development, synaptic plasticity and axogenesis. The majority of energy sources, necessary for cellular functions, originate from oxidative phosphor...Distribution and activity of mitochondda are key factors in neuronal development, synaptic plasticity and axogenesis. The majority of energy sources, necessary for cellular functions, originate from oxidative phosphorylation located in the inner mitochondrial membrane. The adenosine-5＇- triphosphate production is regulated by many control mechanism-firstly by oxygen, substrate level, adenosine-5＇-diphosphate level, mitochondrial membrane potential, and rate of coupling and proton leak. Recently, these mechanisms have been implemented by ＂second control mechanisms,＂ such as reversible phosphorylation of the tricarboxylic acid cycle enzymes and electron transport chain complexes, aUosteric inhibition of cytochrome c oxidase, thyroid hormones, effects of fatty acids and uncoupling proteins. Impaired function of mitochondria is implicated in many diseases ranging from mitochondrial myopathies to bipolar disorder and schizophrenia. Mitochondrial dysfunctions are usually related to the ability of mitochondria to generate adenosine-5＇-triphosphate in response to energy demands. Large amounts of reactive oxygen species are released by defective mitochondria similarly, decline of antioxidative enzyme activities （e.g. in the elderly） enhances reactive oxygen species production. We reviewed data concerning neuroplasticity, physiology, and control of mitochondrial oxidative phosphorylation and reactive oxygen species production.展开更多
The content of cytochrome oxidase (CCO), succinate dehydrogenase (SDH) and neutrophil alkaline phosphatase (NAP) in bone marrow cells in 68 cases of aplastic anemia before and after treatment was determined by com... The content of cytochrome oxidase (CCO), succinate dehydrogenase (SDH) and neutrophil alkaline phosphatase (NAP) in bone marrow cells in 68 cases of aplastic anemia before and after treatment was determined by computerized graphical analysis and compared with that of normal volunteers (control group). The significantly lowered CCO and SDH levels and the markedly increased NAP content before treatment (P<0.01) became approximately normal after that of supplementing the kidney and removing blood stasis (P >0.05).展开更多
The Guandacol Formation corresponds to glacial episode 4 of the“Late Paleozoic Ice Age”in western Gondwana.It represents the final glaciation of westernmost Gondwana and the beginning of deglaciation that swept acro...The Guandacol Formation corresponds to glacial episode 4 of the“Late Paleozoic Ice Age”in western Gondwana.It represents the final glaciation of westernmost Gondwana and the beginning of deglaciation that swept across the supercontinent throughout the rest of the Paleozoic.A succession of transitional sedimentary facies associations characterizes the eastern outcrops of the Guandacol Formation.These facies associations are interlayered with several deposits of mass-transport complexes(MTC)and present the occasional opportunity to conduct a deep-time analysis of the effect of tectonism in what is interpreted to be glacially-influenced deposits.Six sedimentary facies associations were recognized in the lower part of the Guandacol Formation.Facies association 1(interbedded diamictites,sandstones,and mudstones)overlies MTC 1 and is interpreted as sedimentation into a marine glacially-influenced outwash fan.Facies association 2(ponded interbedded sandstones,mudstones,and diamictites)was deposited as subaqueous underflows/turbidites and debris flows covering the irregular paleotopography of MTC 2.Facies association 3(white medium-to coarse-grained sandstones and conglomerates)represents a small deltaic system.Facies association 4(rhythmites with dropstones and sandstones)was deposited in a partially ponded water body resulting from the collapse and paleotopography of MTC 3.Facies association 5(coarsening-upward cycles of mudstones and sandstones)was deposited in prodelta to delta front environments.Finally,facies association 6(conglomerates,sandstones,and mudstones)corresponds to the subaerial deltaic platform.The evolution of depositional environments suggests three glacially-linked stages:Stage 1—Initial retreat of the nearby ice masses(facies association 1);Stage 2—Further retreat of glaciers and the progressive decoupling between ice masses and sea(facies associations 2 and 3);and Stage 3—Postglacial sedimentation dominated by deltaic progradation during highstand conditions(facies associations 4 to 6).The importance of the paleogeographic context is emphasized in which the tectonism triggered recurrent events of MTC that continually modified the topography and sedimentary patterns,interrupting and complicating the stratigraphy of the interpreted glacial and postglacial sedimentation.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.61803275)Liaoning Provincial Department of Education Scientific Research Fund Project,China(Grant Nos.lnjc202018 and lnzd202007)+1 种基金Liaoning BaiQianWan Talents Program(Grant No.2017076)Liaoning Province Doctor Starting Foundation(Grant No.20170520283).
文摘The idea of network splitting according to time delay and weight is introduced.Based on the cyber physical systems(CPS),a class of multi-weighted complex transportation networks with multiple delays is modeled.The finite-time synchronization of the proposed complex transportation networks model is studied systematically.On the basis of the theory of stability,the technique of adaptive control,aperiodically intermittent control and finite-time control,the aperiodically intermittent adaptive finite-time synchronization controller is designed.The controller designed in this paper is beneficial for understanding the synchronization in multi-weighted complex transportation networks with multiple delays.In addition,the conditions for the existence of finite time synchronization have been discussed in detail.And the specific value of the settling finite time for synchronization is obtained.Moreover,the outer coupling configuration matrices are not required to be irreducible or symmetric.Finally,simulation results of the finite-time synchronization problem are given to illustrate the correctness of the results obtained.
基金Supported by the Education Foundation of Hubei Province under Grant No D20120104
文摘We propose a self-organized optimization mechanism to improve the transport capacity of complex gradient networks. We find that, regardless of network topology, the congestion pressure can be strongly reduced by the self-organized optimization mechanism. Furthermore, the random scale-free topology is more efficient to reduce congestion compared with the random Poisson topology under the optimization mechanism. The reason is that the optimization mechanism introduces the correlations between the gradient field and the local topology of the substrate network. Due to the correlations, the cutoff degree of the gradient network is strongly reduced and the number of the nodes exerting their maximal transport capacity consumedly increases. Our work presents evidence supporting the idea that scale-free networks can efficiently improve their transport capacity by self- organized mechanism under gradient-driven transport mode.
基金We greatly appreciate Prof.Charles Wood(University of Nebraska,Lincoln,USA)for the gift of the infectious molecular clones(pNL4.3,pNL4.3ΔEnvEGFP,and pVSV-G).the National Natural Science Foundation of China(81571987)Natural Science Foundation of Tianjin Municipal Science and Technology Commission(20JCQNJC01750,21JCQNJC01600).
文摘Human immunodeficiency virus-1(HIV-1)encodes simply 15 proteins and thus depends on multiple host cellular factors for virus reproduction.Spastin,a microtubule severing protein,is an identified HIV-1 dependency factor,but the mechanism regulating HIV-1 is unclear.Here,the study showed that knockdown of spastin inhibited the production of the intracellular HIV-1 Gag protein and new virions through enhancing Gag lysosomal degradation.Further investigation showed that increased sodium tolerance 1(IST1),the subunit of endosomal sorting complex required for transport(ESCRT),could interact with the MIT domain of spastin to regulate the intracellular Gag production.In summary,spastin is required for HIV-1 replication,while spastin-IST1 interaction facilitates virus production by regulating HIV-1 Gag intracellular trafficking and degradation.Spastin may serve as new target for HIV-1 prophylactic and therapy.
基金supported by grant NoMSM0021620849 given by the Ministry of Education,Youth and Sports of the Czech Republicby project PRVOUK-P26/LF1/4given by Charles University in Prague+1 种基金by grant No. SVV-2012-264514 from Charles University in Pragueby grant No.41310 given by the Grant Agency of Charles University in Prague,Czech Republic
文摘Distribution and activity of mitochondda are key factors in neuronal development, synaptic plasticity and axogenesis. The majority of energy sources, necessary for cellular functions, originate from oxidative phosphorylation located in the inner mitochondrial membrane. The adenosine-5＇- triphosphate production is regulated by many control mechanism-firstly by oxygen, substrate level, adenosine-5＇-diphosphate level, mitochondrial membrane potential, and rate of coupling and proton leak. Recently, these mechanisms have been implemented by ＂second control mechanisms,＂ such as reversible phosphorylation of the tricarboxylic acid cycle enzymes and electron transport chain complexes, aUosteric inhibition of cytochrome c oxidase, thyroid hormones, effects of fatty acids and uncoupling proteins. Impaired function of mitochondria is implicated in many diseases ranging from mitochondrial myopathies to bipolar disorder and schizophrenia. Mitochondrial dysfunctions are usually related to the ability of mitochondria to generate adenosine-5＇-triphosphate in response to energy demands. Large amounts of reactive oxygen species are released by defective mitochondria similarly, decline of antioxidative enzyme activities （e.g. in the elderly） enhances reactive oxygen species production. We reviewed data concerning neuroplasticity, physiology, and control of mitochondrial oxidative phosphorylation and reactive oxygen species production.
文摘 The content of cytochrome oxidase (CCO), succinate dehydrogenase (SDH) and neutrophil alkaline phosphatase (NAP) in bone marrow cells in 68 cases of aplastic anemia before and after treatment was determined by computerized graphical analysis and compared with that of normal volunteers (control group). The significantly lowered CCO and SDH levels and the markedly increased NAP content before treatment (P<0.01) became approximately normal after that of supplementing the kidney and removing blood stasis (P >0.05).
基金supported by the Agencia Nacional de Promoción de la Investigación,el Desarrollo Tecnológico y la Innovación (PICT, 2020-01294)the University of Wisconsin-Milwaukee Center for Latin American and Caribbean Studies,the Nelson Cherkauer Lasca Legacy Scholarshipthe National Science Foundation (Grant No. 1559231)
文摘The Guandacol Formation corresponds to glacial episode 4 of the“Late Paleozoic Ice Age”in western Gondwana.It represents the final glaciation of westernmost Gondwana and the beginning of deglaciation that swept across the supercontinent throughout the rest of the Paleozoic.A succession of transitional sedimentary facies associations characterizes the eastern outcrops of the Guandacol Formation.These facies associations are interlayered with several deposits of mass-transport complexes(MTC)and present the occasional opportunity to conduct a deep-time analysis of the effect of tectonism in what is interpreted to be glacially-influenced deposits.Six sedimentary facies associations were recognized in the lower part of the Guandacol Formation.Facies association 1(interbedded diamictites,sandstones,and mudstones)overlies MTC 1 and is interpreted as sedimentation into a marine glacially-influenced outwash fan.Facies association 2(ponded interbedded sandstones,mudstones,and diamictites)was deposited as subaqueous underflows/turbidites and debris flows covering the irregular paleotopography of MTC 2.Facies association 3(white medium-to coarse-grained sandstones and conglomerates)represents a small deltaic system.Facies association 4(rhythmites with dropstones and sandstones)was deposited in a partially ponded water body resulting from the collapse and paleotopography of MTC 3.Facies association 5(coarsening-upward cycles of mudstones and sandstones)was deposited in prodelta to delta front environments.Finally,facies association 6(conglomerates,sandstones,and mudstones)corresponds to the subaerial deltaic platform.The evolution of depositional environments suggests three glacially-linked stages:Stage 1—Initial retreat of the nearby ice masses(facies association 1);Stage 2—Further retreat of glaciers and the progressive decoupling between ice masses and sea(facies associations 2 and 3);and Stage 3—Postglacial sedimentation dominated by deltaic progradation during highstand conditions(facies associations 4 to 6).The importance of the paleogeographic context is emphasized in which the tectonism triggered recurrent events of MTC that continually modified the topography and sedimentary patterns,interrupting and complicating the stratigraphy of the interpreted glacial and postglacial sedimentation.
