Dear Editor,Burkitt's lymphoma(BL)is a highly aggressive B-cell lymphoma and one of the fastest-growing tumors,driven by hallmark MYC oncogene translocation.While BL is often curable with high-dose chemotherapy,re...Dear Editor,Burkitt's lymphoma(BL)is a highly aggressive B-cell lymphoma and one of the fastest-growing tumors,driven by hallmark MYC oncogene translocation.While BL is often curable with high-dose chemotherapy,relapsed/refractory cases have a poor prognosis,even with CD19-targeted chimeric antigen receptor T-cell(CAR-T)therapy1 or immune checkpoint inhibitors.Therefore,BL is considered a cold tumor that may be triggered by MYC dysregulation.展开更多
基金supported by JSPS KAKENHI grant number JP23744746(to HK)the Scholarship Donation Program by Daiichi-Sankyo(to HK)We thank Dr.Steven P.Langston(Millennium Pharmaceuticals)for kindly providing the instructions for preparing the TAK-981 solution for the in vivo study.
文摘Dear Editor,Burkitt's lymphoma(BL)is a highly aggressive B-cell lymphoma and one of the fastest-growing tumors,driven by hallmark MYC oncogene translocation.While BL is often curable with high-dose chemotherapy,relapsed/refractory cases have a poor prognosis,even with CD19-targeted chimeric antigen receptor T-cell(CAR-T)therapy1 or immune checkpoint inhibitors.Therefore,BL is considered a cold tumor that may be triggered by MYC dysregulation.
