This paper presents a thin-film,three-dimensional(3D)opto-electro array featuring four addressable microscale light-emitting diodes(LEDs)for surface cortex illumination and nine penetrating electrodes for simultaneous...This paper presents a thin-film,three-dimensional(3D)opto-electro array featuring four addressable microscale light-emitting diodes(LEDs)for surface cortex illumination and nine penetrating electrodes for simultaneous recording of light-evoked neural activities.Inspired by the origami concept,we have developed a meticulously designed“bridge+trench”structure that facilitates the transformation of the array from 2D to 3D while preventing damage to the thin film metal.Prior to device transformation,the shape and dimensions of the 2D array can be customized,enhancing its versatility for various applications.In addition,the arched base offers strong mechanical support to facilitate the direct insertion of the probe into tissue without any mechanical reinforcement.The array was encapsulated using polyimide and epoxy to ensure mechanical flexibility and biocompatibility of the device.The efficacy of the device was evaluated through comprehensive in vitro and in vivo characterization.展开更多
Metal-organic frameworks(MOFs)have been widely considered as ideal platforms for the preparation of biomimetic catalysts,but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity.He...Metal-organic frameworks(MOFs)have been widely considered as ideal platforms for the preparation of biomimetic catalysts,but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity.Here,we leverage the inherent flexibility of MOFs and propose a novel trans-functionalization strategy to construct a carbonic anhydrase(CA)mimic by the structural transformation from ZIF-L to ZIF-8.Theoretical and experimental results reveal that during the structural transformation,the hydroxyl group will preferentially coordinate with the interlayer Zn clusters to form the CA-like active center Zn-N3-OH.Therefore,more accessible active centers are generated on the as-prepared ZIF-8-OH,resulting in substantially enhanced catalytic activity in the hydrolysis of para-nitrophenyl acetate.展开更多
基金supported by the National Science Foundation under award numbers ECCS-2024270.
文摘This paper presents a thin-film,three-dimensional(3D)opto-electro array featuring four addressable microscale light-emitting diodes(LEDs)for surface cortex illumination and nine penetrating electrodes for simultaneous recording of light-evoked neural activities.Inspired by the origami concept,we have developed a meticulously designed“bridge+trench”structure that facilitates the transformation of the array from 2D to 3D while preventing damage to the thin film metal.Prior to device transformation,the shape and dimensions of the 2D array can be customized,enhancing its versatility for various applications.In addition,the arched base offers strong mechanical support to facilitate the direct insertion of the probe into tissue without any mechanical reinforcement.The array was encapsulated using polyimide and epoxy to ensure mechanical flexibility and biocompatibility of the device.The efficacy of the device was evaluated through comprehensive in vitro and in vivo characterization.
基金supported by the National Natural Science Foundation of China(62288102,22305116,21908105,21727808,and 21971114)the Jiangsu Provincial Funds for Natural Science Foundation(BK20230308 and BK20200090).
文摘Metal-organic frameworks(MOFs)have been widely considered as ideal platforms for the preparation of biomimetic catalysts,but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity.Here,we leverage the inherent flexibility of MOFs and propose a novel trans-functionalization strategy to construct a carbonic anhydrase(CA)mimic by the structural transformation from ZIF-L to ZIF-8.Theoretical and experimental results reveal that during the structural transformation,the hydroxyl group will preferentially coordinate with the interlayer Zn clusters to form the CA-like active center Zn-N3-OH.Therefore,more accessible active centers are generated on the as-prepared ZIF-8-OH,resulting in substantially enhanced catalytic activity in the hydrolysis of para-nitrophenyl acetate.
